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Conserved domains on  [gi|1820456424|ref|NP_001182361|]
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myeloid leukemia factor 1 isoform 5 [Homo sapiens]

Protein Classification

myeloid leukemia factor( domain architecture ID 10563012)

myeloid leukemia factor such as human myeloid leukemia factor 1 that is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mlf1IP pfam10248
Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved ...
 1-192 5.73e-94

Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.


:

Pssm-ID: 463022 [Multi-domain]  Cd Length: 174  Bit Score: 273.84  E-value: 5.73e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424   1 MRQMIRSFSEPFGRD-LLSISDGRGRAHNRRGHNDGedsltatscslvpfgdfggMHTDVSSFQTMDQMVSNMRNYMQKL 79
Cdd:pfam10248   1 MRQMMRSFSDPFGQFfMPSITDGRERGRGGAEHPNH-------------------GAMARNPFGMMDGMFSNMRNRMEEM 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424  80 ERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKK 159
Cdd:pfam10248  62 HRNFEGMSNDPNGHSFSSSSVMTYSKVGDGPPKVYQASSSTRSAPGGIKETRRAVRDSESGLEKMAIGHHIGDRGHVVEK 141

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1820456424 160 SKNKKTGDEEVNQEFINMNESDAHAFDEEWQSE 192
Cdd:pfam10248 142 KRNKKTGDVEENQDFINLDESEAESFDEEWQRR 174
 
Name Accession Description Interval E-value
Mlf1IP pfam10248
Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved ...
 1-192 5.73e-94

Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.


Pssm-ID: 463022 [Multi-domain]  Cd Length: 174  Bit Score: 273.84  E-value: 5.73e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424   1 MRQMIRSFSEPFGRD-LLSISDGRGRAHNRRGHNDGedsltatscslvpfgdfggMHTDVSSFQTMDQMVSNMRNYMQKL 79
Cdd:pfam10248   1 MRQMMRSFSDPFGQFfMPSITDGRERGRGGAEHPNH-------------------GAMARNPFGMMDGMFSNMRNRMEEM 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424  80 ERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKK 159
Cdd:pfam10248  62 HRNFEGMSNDPNGHSFSSSSVMTYSKVGDGPPKVYQASSSTRSAPGGIKETRRAVRDSESGLEKMAIGHHIGDRGHVVEK 141

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1820456424 160 SKNKKTGDEEVNQEFINMNESDAHAFDEEWQSE 192
Cdd:pfam10248 142 KRNKKTGDVEENQDFINLDESEAESFDEEWQRR 174
 
Name Accession Description Interval E-value
Mlf1IP pfam10248
Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved ...
 1-192 5.73e-94

Myelodysplasia-myeloid leukemia factor 1-interacting protein; This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.


Pssm-ID: 463022 [Multi-domain]  Cd Length: 174  Bit Score: 273.84  E-value: 5.73e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424   1 MRQMIRSFSEPFGRD-LLSISDGRGRAHNRRGHNDGedsltatscslvpfgdfggMHTDVSSFQTMDQMVSNMRNYMQKL 79
Cdd:pfam10248   1 MRQMMRSFSDPFGQFfMPSITDGRERGRGGAEHPNH-------------------GAMARNPFGMMDGMFSNMRNRMEEM 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820456424  80 ERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKK 159
Cdd:pfam10248  62 HRNFEGMSNDPNGHSFSSSSVMTYSKVGDGPPKVYQASSSTRSAPGGIKETRRAVRDSESGLEKMAIGHHIGDRGHVVEK 141

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1820456424 160 SKNKKTGDEEVNQEFINMNESDAHAFDEEWQSE 192
Cdd:pfam10248 142 KRNKKTGDVEENQDFINLDESEAESFDEEWQRR 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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