|
Name |
Accession |
Description |
Interval |
E-value |
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
107-521 |
3.67e-39 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 148.87 E-value: 3.67e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 107 INLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSynvDVNIR 186
Cdd:PHA02878 20 IEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR---SINKC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 187 NFTYWYSALHEA-------------------------VQI----GDSKISRCIVSLLLCNKANVNTRCR-LNTTPIFYAI 236
Cdd:PHA02878 97 SVFYTLVAIKDAfnnrnveifkiiltnrykniqtidlVYIdkksKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYAT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 237 NCIDT--LKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATEN-YSYRNMKLLLD 313
Cdd:PHA02878 177 ENKDQrlTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLE 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 314 HGSNPNIADHIMN-TPLFISIKCTciENTKMLLDSGADINHVNDNGETPISYLAPNLIPTPVAILVISHIVLLKTKYNHI 392
Cdd:PHA02878 257 HGVDVNAKSYILGlTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKQYLCINIGRILISNICLLKRIKPDI 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 393 KYLPGFIKNISVIQNFTKFNNIKKVCEDEFRFMRSVSLSANHNLSSYICNDNLHTLVRFIKNPKI-YYSINKIRIYRNRL 471
Cdd:PHA02878 335 KNSEGFIDNMDCITSNKRLNQIKDKCEDELNRLASIKITNTYSFDDFLKCDNSTLLCKLVNNSIIdDILIDSFNIYGNII 414
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 18203040 472 YSIIERLLNRKKLHDLVLELIKDI------GVFNKLPLDIISMILDFLSDDDLALM 521
Cdd:PHA02878 415 KKNIYRARKRLLLIEGAIYSLDNIffekqnYMWNRLPLEIKHYIMELLDDASLCNM 470
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
106-395 |
1.86e-35 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 134.31 E-value: 1.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 106 IINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 186 RNFtYWYSALHEAVQIGDSKIsrciVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGADINATSDNDNAVI 263
Cdd:COG0666 83 KDD-GGNTLLHAAARNGDLEI----VKLLLEAGADVNARDKDGETPLHLAAynGNLEIVKLLLEAGADVNAQDNDGNTPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 264 HLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKM 343
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 18203040 344 LLDSGADINHVNDNGETPISYLAPNLIPTPVAILVISHIVLLKTKYNHIKYL 395
Cdd:COG0666 238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
128-224 |
6.56e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 6.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 128 LHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYnvdVNIRNFTYWYSALHEAVQIGDSKis 207
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLE-- 75
|
90
....*....|....*..
gi 18203040 208 rcIVSLLLCNKANVNTR 224
Cdd:pfam12796 76 --IVKLLLEKGADINVK 90
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
113-301 |
3.22e-10 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 62.79 E-value: 3.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 113 KKANINACNNLNQTPL-HLAAESNNTTLLKILLYNNAKVNIldiyGNTCLHYAVRG--RNIESIKLLL----------SY 179
Cdd:TIGR00870 41 KKLNINCPDRLGRSALfVAAIENENLELTELLLNLSCRGAV----GDTLLHAISLEyvDAVEAILLHLlaafrksgplEL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 180 NVDVNIRNFTYWYSALHEAVQIGDSKisrcIVSLLLCNKANVNTRC-------------------RLNttpIFYAINCID 240
Cdd:TIGR00870 117 ANDQYTSEFTPGITALHLAAHRQNYE----IVKLLLERGASVPARAcgdffvksqgvdsfyhgesPLN---AAACLGSPS 189
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18203040 241 TLKLLLENGADINATSDNDNAVIHLA---TENRR---------YDIIKTLLDYGADVN----MIGYRGKTPLYYATE 301
Cdd:TIGR00870 190 IVALLSEDPADILTADSLGNTLLHLLvmeNEFKAeyeelscqmYNFALSLLDKLRDSKelevILNHQGLTPLKLAAK 266
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
44-154 |
5.83e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 55.89 E-value: 5.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 44 LLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIAMdyyvphndikHGHHNdyvfkmvpIINLFLrKKANINACNNl 123
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAK----------NGHLE--------IVKLLL-EHADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 18203040 124 NQTPLHLAAESNNTTLLKILLYNNAKVNILD 154
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
12-180 |
2.97e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 59.27 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 12 HAVSINDRFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTD--MIKTLLDYGICINTRDILGNTALHLIAmDYYVPHN 89
Cdd:PHA03095 124 YLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLHHHL-QSFKPRA 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 90 DI-------------KHGHHNDYVFKMV-------PIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAK 149
Cdd:PHA03095 203 RIvreliragcdpaaTDMLGNTPLHSMAtgssckrSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGAD 282
|
170 180 190
....*....|....*....|....*....|.
gi 18203040 150 VNILDIYGNTCLHYAVRGRNIESIKLLLSYN 180
Cdd:PHA03095 283 INAVSSDGNTPLSLMVRNNNGRAVRAALAKN 313
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
27-152 |
8.68e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 45.46 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 27 EKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYgicINTRDILGNTALHLIAMDYYVPHNDI------KHGHHNDYV 100
Cdd:TIGR00870 39 EPKKLNINCPDRLGRSALFVAAIENENLELTELLLN---LSCRGAVGDTLLHAISLEYVDAVEAIllhllaAFRKSGPLE 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 18203040 101 FKMVPIINLFLRkkaninacnnlNQTPLHLAAESNNTTLLKILLYNNAKVNI 152
Cdd:TIGR00870 116 LANDQYTSEFTP-----------GITALHLAAHRQNYEIVKLLLERGASVPA 156
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
191-331 |
7.31e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 42.31 E-value: 7.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 191 WYSALHEAVQIGDSkisRCIVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGAD-IN--ATSD--NDNAVI 263
Cdd:cd22192 17 SESPLLLAAKENDV---QAIKKLLKCPSCDLFQRGALGETALHVAAlyDNLEAAVVLMEAAPElVNepMTSDlyQGETAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 264 HLATENRRYDIIKTLLDYGADV---------------NMIgYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTP 328
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspratgtffrpgpkNLI-YYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
|
...
gi 18203040 329 LFI 331
Cdd:cd22192 173 LHI 175
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
156-185 |
1.25e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 1.25e-03
10 20 30
....*....|....*....|....*....|
gi 18203040 156 YGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
107-521 |
3.67e-39 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 148.87 E-value: 3.67e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 107 INLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSynvDVNIR 186
Cdd:PHA02878 20 IEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR---SINKC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 187 NFTYWYSALHEA-------------------------VQI----GDSKISRCIVSLLLCNKANVNTRCR-LNTTPIFYAI 236
Cdd:PHA02878 97 SVFYTLVAIKDAfnnrnveifkiiltnrykniqtidlVYIdkksKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYAT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 237 NCIDT--LKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATEN-YSYRNMKLLLD 313
Cdd:PHA02878 177 ENKDQrlTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLE 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 314 HGSNPNIADHIMN-TPLFISIKCTciENTKMLLDSGADINHVNDNGETPISYLAPNLIPTPVAILVISHIVLLKTKYNHI 392
Cdd:PHA02878 257 HGVDVNAKSYILGlTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKQYLCINIGRILISNICLLKRIKPDI 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 393 KYLPGFIKNISVIQNFTKFNNIKKVCEDEFRFMRSVSLSANHNLSSYICNDNLHTLVRFIKNPKI-YYSINKIRIYRNRL 471
Cdd:PHA02878 335 KNSEGFIDNMDCITSNKRLNQIKDKCEDELNRLASIKITNTYSFDDFLKCDNSTLLCKLVNNSIIdDILIDSFNIYGNII 414
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 18203040 472 YSIIERLLNRKKLHDLVLELIKDI------GVFNKLPLDIISMILDFLSDDDLALM 521
Cdd:PHA02878 415 KKNIYRARKRLLLIEGAIYSLDNIffekqnYMWNRLPLEIKHYIMELLDDASLCNM 470
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
106-395 |
1.86e-35 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 134.31 E-value: 1.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 106 IINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 186 RNFtYWYSALHEAVQIGDSKIsrciVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGADINATSDNDNAVI 263
Cdd:COG0666 83 KDD-GGNTLLHAAARNGDLEI----VKLLLEAGADVNARDKDGETPLHLAAynGNLEIVKLLLEAGADVNAQDNDGNTPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 264 HLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKM 343
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 18203040 344 LLDSGADINHVNDNGETPISYLAPNLIPTPVAILVISHIVLLKTKYNHIKYL 395
Cdd:COG0666 238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
44-362 |
1.85e-34 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 131.61 E-value: 1.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 44 LLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIAMDYYVPHNDIKHGHHNDYVFKMVPIINLFLRKKANINACNNL 123
Cdd:COG0666 7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 124 NQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNIRNfTYWYSALHEAVQIGD 203
Cdd:COG0666 87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAAANGN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 204 skisrcivslllcnkanvntrcrlnttpifyaincIDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGA 283
Cdd:COG0666 166 -----------------------------------LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18203040 284 DVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKMLLDSGADINHVNDNGETPI 362
Cdd:COG0666 211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
10-329 |
3.41e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 122.37 E-value: 3.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 10 LYHAVSINDRFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIAMDyyvphn 89
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN------ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 90 dikhghhndyvfKMVPIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRN 169
Cdd:COG0666 98 ------------GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 170 IESIKLLLSYNVDVNIRNfTYWYSALHEAVQIGDskisrcivslllcnkanvntrcrlnttpifyaincIDTLKLLLENG 249
Cdd:COG0666 166 LEIVKLLLEAGADVNARD-NDGETPLHLAAENGH-----------------------------------LEIVKLLLEAG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 250 ADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPL 329
Cdd:COG0666 210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
28-518 |
5.25e-31 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 124.78 E-value: 5.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 28 KKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIAMDYYVPHNDikhghhndyvfkmVPII 107
Cdd:PHA03100 23 MEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDV-------------KEIV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 108 NLFLRKKANINACNNLNQTPLHLAA--ESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIEsiklllsynvdvni 185
Cdd:PHA03100 90 KLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKID-------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 186 rnftywysalheavqigdskisrcivslllcnkanvntrcrlnttpifyaincIDTLKLLLENGADINATsdndnavihl 265
Cdd:PHA03100 156 -----------------------------------------------------LKILKLLIDKGVDINAK---------- 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 266 atenrryDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKMLL 345
Cdd:PHA03100 173 -------NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 346 DSGADINHVNDNgetpISYLAPNLIPTPVAILVISHIVLLKTKYNhikylPGFIKNISVIQNFTKFNNIKKVCEDEFRFM 425
Cdd:PHA03100 246 NNGPSIKTIIET----LLYFKDKDLNTITKIKMLKKSIMYMFLLD-----PGFYKNRKLIENSKSLKDVINECEKEIERM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 426 RSVSLSaNHNLSSYICNDNLHTLVRFIKNPKIyYSINKIRIYRNRLYSIIERLLNRKKLHDLVLELIKDI---GVFNKLP 502
Cdd:PHA03100 317 KEIKLN-KVTVYDIIFNKNINFLSRYVNNKSV-TKYTTSKIYGKYIKKVINKAIERKKLIKKIIKKLNNLcknTYWNILP 394
|
490
....*....|....*.
gi 18203040 503 LDIISMILDFLSDDDL 518
Cdd:PHA03100 395 IEIKYKILEYLSNRDL 410
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
139-401 |
2.50e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 120.06 E-value: 2.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 139 LLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNIRNFTYWYSALHEAVQIGDSKIsrciVSLLLCNK 218
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLV----ALLLLAAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 219 ANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPL 296
Cdd:COG0666 78 ADINAKDDGGNTLLHAAArnGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 297 YYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKMLLDSGADINHVNDNGETPISYLAPNLIPTPVAI 376
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
250 260
....*....|....*....|....*
gi 18203040 377 LVISHIVLLKTKYNHIKYLPGFIKN 401
Cdd:COG0666 238 LLEAGADLNAKDKDGLTALLLAAAA 262
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
4-518 |
7.06e-30 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 124.02 E-value: 7.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 4 MSSIKELYHavsiNDRFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGntalhLIAMD 83
Cdd:PHA02876 146 MKLIKERIQ----QDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDD-----LSVLE 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 84 YYVPHNDIkhghhnDYVfkmvpiinlflrkKANINACNNLNQTPLHLAAESNNTTL-LKILLYNNA-KVNILDIYGNTCL 161
Cdd:PHA02876 217 CAVDSKNI------DTI-------------KAIIDNRSNINKNDLSLLKAIRNEDLeTSLLLYDAGfSVNSIDDCKNTPL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 162 HYAVRGRNIES-IKLLLSYNVDVNIRNFTYWYSALHEAVQIGDSKISRCIVSLllcnKANVNTRCRLNTTPIFYAINC-- 238
Cdd:PHA02876 278 HHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIML----GADVNAADRLYITPLHQASTLdr 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 239 -IDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYS-YRNMKLLLDHGS 316
Cdd:PHA02876 354 nKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGA 433
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 317 NPNIADHIMNTPLFISIKCTC-IENTKMLLDSGADINHVNDNGETPI-----------------------SYLAPNLIPT 372
Cdd:PHA02876 434 NVNSKNKDLSTPLHYACKKNCkLDVIEMLLDNGADVNAINIQNQYPLlialeyhgivnillhygaelrdsRVLHKSLNDN 513
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 373 PVAI-LVISHIVL-------LKTKYNHIKYLPGFIKNI-----SVIQNFTKFNNIKKVCEDEFRFMRSVSLSANHNLSSY 439
Cdd:PHA02876 514 MFSFrYIIAHICIqdfirhdIRNEVNPLKRVPTRFTSLresfkEIIQSDDTFKRIWLRCKEELKDISKIRINMFYSLDIF 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 440 ICNDNLHTLVRFIKNPkIYYSINKIRI--YRNRLYSIIERLLNRKKLHDLV---LELIKDIGVFNKLPLDIISMILDFLS 514
Cdd:PHA02876 594 IISKNMNLLHHLVNNP-IIKEINTWHFcnYGDRLKTSISLASDRHEILEKSrskLDEILDSSDWSKLPPDIKLSILEFID 672
|
....
gi 18203040 515 DDDL 518
Cdd:PHA02876 673 NNEL 676
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
104-525 |
2.39e-28 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 117.82 E-value: 2.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 104 VPIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKI---LLYNNAKVNILDIYGNTCLHYAVRGRN-IESIKLLLSY 179
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 180 NVDVNIRNFtYWYSALHeaVQIGDSKISRCIVSLLLCNKANVNTRCRLNTTPIFYAIN----CIDTLKLLLENGADINAT 255
Cdd:PHA03095 107 GADVNAKDK-VGRTPLH--VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKsrnaNVELLRLLIDAGADVYAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 256 SDNDNAVIHLATENRR--YDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKL--LLDHGSNPNIADHIMNTPLFI 331
Cdd:PHA03095 184 DDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHY 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 332 SikcTCIENTKM---LLDSGADINHVNDNGETPISYL-----------APNLIPTPVAI--------LVISHIVLLKTK- 388
Cdd:PHA03095 264 A---AVFNNPRAcrrLIALGADINAVSSDGNTPLSLMvrnnngravraALAKNPSAETVaatlntasVAGGDIPSDATRl 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 389 ---YNHIKYLPGFIKNiSVIQNFTKFnnIKKvCEDEFRFMRSVSLSANHNLSSYICNDNLHTLVRFIKNPKIYYSinkIR 465
Cdd:PHA03095 341 cvaKVVLRGAFSLLPE-PIRAYHADF--IRE-CEAEIAVMRTTRIGTGVSLLDILFARNPDILLVSNASLRKKAR---LT 413
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 466 IYRNRLYSIIERLLNRKKlhdLVLELIKDIGVfNKLPLDIISMILDFLSDDDLALMAIFN 525
Cdd:PHA03095 414 VYGKALRARIEEMRKRSK---LVERIIKLICP-CALPPEIVMRILDFLPDDDLRNLLRCL 469
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
131-518 |
2.20e-24 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 105.46 E-value: 2.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 131 AAESNNTTLLKILL--YNNAKVNILDiyGNTCLHYAVRGRNIESIKLLLSYNVDVNIrNFTYWYSALHEAVQIGDSKisr 208
Cdd:PHA02875 9 AILFGELDIARRLLdiGINPNFEIYD--GISPIKLAMKFRDSEAIKLLMKHGAIPDV-KYPDIESELHDAVEEGDVK--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 209 CIVSLLLCNKANVNTRCRLNTTPIFYA--INCIDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVN 286
Cdd:PHA02875 83 AVEELLDLGKFADDVFYKDGMTPLHLAtiLKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 287 MIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNiadHIMNTPLfISIKCTCIENTK-----MLLDSGADINHVN--DNGE 359
Cdd:PHA02875 163 IEDCCGCTPLIIAMAKGDIAICKMLLDSGANID---YFGKNGC-VAALCYAIENNKidivrLFIKRGADCNIMFmiEGEE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 360 TPISYLAPNLIPTPVAILV---ISHIVLLKTKyNHIKYLPGFIKNISVIQNFTKFNNIKKVCEDEFRFMRSVSLSANHNL 436
Cdd:PHA02875 239 CTILDMICNMCTNLESEAIdalIADIAIRIHK-KTIRRDEGFKNNMSTIEDKEEFKDVFEKCIIELRRIKSEKIGKKNIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 437 SSYICNDNLH-----TLVRFIKnpKIYYSINKIRIYRNRLYSIIERLLNRKKLHDLVLELIKDIGVFNK-----LPLDII 506
Cdd:PHA02875 318 DLCILEKNSHnldenILARHSK--KILGLNDEAHFYKYLLKEAADIALKRAEAIESAIRVIDDEITGDEskwniLPHEIK 395
|
410
....*....|..
gi 18203040 507 SMILDFLSDDDL 518
Cdd:PHA02875 396 YLILEKIGNKDI 407
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
173-366 |
4.19e-21 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 93.48 E-value: 4.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 173 IKLLLSYNVDVNIRNFTYWYSALHEAVQIGDSKISRCIVSLLLCNKANVNTRCRLNTTPIFYAINCIDTLKLLLENGADI 252
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 253 NATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFIS 332
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
170 180 190
....*....|....*....|....*....|....
gi 18203040 333 IKCTCIENTKMLLDSGADINHVNDNGETPISYLA 366
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
106-436 |
3.24e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 93.10 E-value: 3.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 106 IINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:PHA02874 17 IEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 186 rnftywysalheaVQIGDskISRCIVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGADINATSDNDNAVI 263
Cdd:PHA02874 97 -------------LPIPC--IEKDMIKTILDCGIDVNIKDAELKTFLHYAIkkGDLESIKMLFEYGADVNIEDDNGCYPI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 264 HLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSN-------------------------- 317
Cdd:PHA02874 162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHimnkckngftplhnaiihnrsaiell 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 318 -----PNIADHIMNTPLFISIKCTC-IENTKMLLDSGADINHVNDNGETPISYLAPNLIPTPVAILVISHIVLLktkyNH 391
Cdd:PHA02874 242 innasINDQDIDGSTPLHHAINPPCdIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLI----KE 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 18203040 392 IKYLPG--FIKNISVIQNfTKFNNIKKVCEDEFRFMRSVSLSANHNL 436
Cdd:PHA02874 318 ADKLKDsdFLEHIEIKDN-KEFSDFIKECNEEIEDMKKTKCGCDKNI 363
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
22-279 |
1.68e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 81.93 E-value: 1.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 22 VVNILEKKNIPIDYINFHPDNPLLEAVKL-----------------------TNTDMIKTLLDYGICINTRDILGNTALH 78
Cdd:PHA02874 50 IVELFIKHGADINHINTKIPHPLLTAIKIgahdiikllidngvdtsilpipcIEKDMIKTILDCGIDVNIKDAELKTFLH 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 79 liamdYYVPHNDIKhghhndyvfkmvpIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGN 158
Cdd:PHA02874 130 -----YAIKKGDLE-------------SIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 159 TCLHYAVRGRNIESIKLLLSYNVDVNIRnFTYWYSALHEAVQIGDSKISrcivslLLCNKANVNTRCRLNTTPIFYAIN- 237
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNGFTPLHNAIIHNRSAIE------LLINNASINDQDIDGSTPLHHAINp 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 18203040 238 --CIDTLKLLLENGADINATSDNDNAVIHLATEN-RRYDIIKTLL 279
Cdd:PHA02874 265 pcDIDIIDILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKDII 309
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
128-224 |
6.56e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 6.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 128 LHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYnvdVNIRNFTYWYSALHEAVQIGDSKis 207
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLE-- 75
|
90
....*....|....*..
gi 18203040 208 rcIVSLLLCNKANVNTR 224
Cdd:pfam12796 76 --IVKLLLEKGADINVK 90
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
101-187 |
1.44e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 68.99 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 101 FKMVPIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLyNNAKVNILDiYGNTCLHYAVRGRNIESIKLLLSYN 180
Cdd:pfam12796 7 NGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
|
....*..
gi 18203040 181 VDVNIRN 187
Cdd:pfam12796 85 ADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
263-355 |
1.01e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 263 IHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGsNPNIADHiMNTPLFISIKCTCIENTK 342
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 18203040 343 MLLDSGADINHVN 355
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
237-322 |
1.48e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.60 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 237 NCIDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYgADVNMIGYrGKTPLYYATENYSYRNMKLLLDHGS 316
Cdd:pfam12796 8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGA 85
|
....*.
gi 18203040 317 NPNIAD 322
Cdd:pfam12796 86 DINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
237-362 |
2.50e-12 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 68.90 E-value: 2.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 237 NCIDTLKLLLENGADINATSDNDNAVIHLATENR---RYDIIKTLLDYGADVNMIGYRGKTPL-YYATENYSYRNMKLLL 312
Cdd:PHA03095 25 VTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLI 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 18203040 313 DHGSNPNIADHIMNTPLFISIKCTCIeNTKM---LLDSGADINHVNDNGETPI 362
Cdd:PHA03095 105 KAGADVNAKDKVGRTPLHVYLSGFNI-NPKVirlLLRKGADVNALDLYGMTPL 156
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
195-286 |
1.16e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 60.90 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 195 LHEAVQIGDSKIsrciVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENgADINATSDNDNAvIHLATENRRY 272
Cdd:pfam12796 1 LHLAAKNGNLEL----VKLLLENGADANLQDKNGRTALHLAAknGHLEIVKLLLEH-ADVNLKDNGRTA-LHYAARSGHL 74
|
90
....*....|....
gi 18203040 273 DIIKTLLDYGADVN 286
Cdd:pfam12796 75 EIVKLLLEKGADIN 88
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
113-301 |
3.22e-10 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 62.79 E-value: 3.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 113 KKANINACNNLNQTPL-HLAAESNNTTLLKILLYNNAKVNIldiyGNTCLHYAVRG--RNIESIKLLL----------SY 179
Cdd:TIGR00870 41 KKLNINCPDRLGRSALfVAAIENENLELTELLLNLSCRGAV----GDTLLHAISLEyvDAVEAILLHLlaafrksgplEL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 180 NVDVNIRNFTYWYSALHEAVQIGDSKisrcIVSLLLCNKANVNTRC-------------------RLNttpIFYAINCID 240
Cdd:TIGR00870 117 ANDQYTSEFTPGITALHLAAHRQNYE----IVKLLLERGASVPARAcgdffvksqgvdsfyhgesPLN---AAACLGSPS 189
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18203040 241 TLKLLLENGADINATSDNDNAVIHLA---TENRR---------YDIIKTLLDYGADVN----MIGYRGKTPLYYATE 301
Cdd:TIGR00870 190 IVALLSEDPADILTADSLGNTLLHLLvmeNEFKAeyeelscqmYNFALSLLDKLRDSKelevILNHQGLTPLKLAAK 266
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
44-154 |
5.83e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 55.89 E-value: 5.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 44 LLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIAMdyyvphndikHGHHNdyvfkmvpIINLFLrKKANINACNNl 123
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAK----------NGHLE--------IVKLLL-EHADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 18203040 124 NQTPLHLAAESNNTTLLKILLYNNAKVNILD 154
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
126-177 |
9.69e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.20 E-value: 9.69e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 18203040 126 TPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLL 177
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
12-180 |
2.97e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 59.27 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 12 HAVSINDRFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTD--MIKTLLDYGICINTRDILGNTALHLIAmDYYVPHN 89
Cdd:PHA03095 124 YLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLHHHL-QSFKPRA 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 90 DI-------------KHGHHNDYVFKMV-------PIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAK 149
Cdd:PHA03095 203 RIvreliragcdpaaTDMLGNTPLHSMAtgssckrSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGAD 282
|
170 180 190
....*....|....*....|....*....|.
gi 18203040 150 VNILDIYGNTCLHYAVRGRNIESIKLLLSYN 180
Cdd:PHA03095 283 INAVSSDGNTPLSLMVRNNNGRAVRAALAKN 313
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
10-187 |
4.29e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 55.35 E-value: 4.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 10 LYHAVSINDrFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALhliamdyyvpHN 89
Cdd:PHA02874 128 LHYAIKKGD-LESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL----------HN 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 90 DIKHGhhnDYvfkmvPIINLFLRKKANI-NACNNlNQTPLHLAAESNNTTLLkiLLYNNAKVNILDIYGNTCLHYAVRGR 168
Cdd:PHA02874 197 AAEYG---DY-----ACIKLLIDHGNHImNKCKN-GFTPLHNAIIHNRSAIE--LLINNASINDQDIDGSTPLHHAINPP 265
|
170 180
....*....|....*....|
gi 18203040 169 -NIESIKLLLSYNVDVNIRN 187
Cdd:PHA02874 266 cDIDIIDILLYHKADISIKD 285
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
195-371 |
9.17e-08 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 54.67 E-value: 9.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 195 LHEAVQIGDSKIsrciVSLLLCNKANVNTRCRLNTTPIFYAI----NCIDTLKLLLENGADINATSDNDNAVIHLATENR 270
Cdd:PHA02946 76 LHIASKINNNRI----VAMLLTHGADPNACDKQHKTPLYYLSgtddEVIERINLLVQYGAKINNSVDEEGCGPLLACTDP 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 271 RYDIIKTLLDYGADVNMIGYRGKTPL--YYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTcIENTKM--LLD 346
Cdd:PHA02946 152 SERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKT-VKNVDIinLLL 230
|
170 180
....*....|....*....|....*
gi 18203040 347 SGADINHVNDNGETPISYLAPNLIP 371
Cdd:PHA02946 231 PSTDVNKQNKFGDSPLTLLIKTLSP 255
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
103-518 |
9.56e-08 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 54.46 E-value: 9.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 103 MVPIINLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLY---NNAKVNILDIYGNTCLHYAVRGRN---IESIKLL 176
Cdd:PHA02798 88 MLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLFmieNGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 177 LSYNVDVNIRNFTYWYSALHEAVQigdskisrcivslllcnkanvntrcrlnttpifYAINCIDT--LKLLLENGADINA 254
Cdd:PHA02798 168 LEKGVDINTHNNKEKYDTLHCYFK---------------------------------YNIDRIDAdiLKLFVDNGFIINK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 255 TSDNDNA-----VIHLATENRRY--DIIKTLLDYgADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNT 327
Cdd:PHA02798 215 ENKSHKKkfmeyLNSLLYDNKRFkkNILDFIFSY-IDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNT 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 328 PLFISIKCTCIENTKMLLDSGADIN-----------HVNDNGETPISYLAPNLIPtpvaiLVISHIVLLKTKYNhikylp 396
Cdd:PHA02798 294 CLFTAFENESKFIFNSILNKKPNKNtisytyyklrkHILNVEGDFINQLEFDIIK-----KFIAYVILYVKNFS------ 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 397 gfIKNISVIQNFTKFNNIKKVCEDEFRFMRSVSLSanhNLSSY-ICNDNLHTLVRFIKNPKIyYSINKIRIYRNRLYSII 475
Cdd:PHA02798 363 --IRNLTYPFIFTYFDDFIEKCTKSINEIHNTYVN---NETIFqICFNKKYIPIKYINNKKL-KKYTKLFYYGNIIKKII 436
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 18203040 476 ERLLNRKKLHDLVLELIKDI-----GVFNKLPLDIISMILDFLSDDDL 518
Cdd:PHA02798 437 EKSKKRYENIYKVSCYITKIcsnelSYWNYIPNEIKFKIINNLSNNDI 484
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
228-279 |
1.10e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.42 E-value: 1.10e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 18203040 228 NTTPIFYAI--NCIDTLKLLLENGADINATSDNDNAVIHLATENRRYDIIKTLL 279
Cdd:pfam13637 1 ELTALHAAAasGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
243-314 |
2.66e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 53.36 E-value: 2.66e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18203040 243 KLLLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDH 314
Cdd:PTZ00322 99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
116-285 |
7.85e-07 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 50.81 E-value: 7.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 116 NINACNNL--NQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNIRNFTYWYS 193
Cdd:PHA02791 51 NAGALKNLleNEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGNMQTVKLFVKKNWRLMFYGKTGWKT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 194 ALHEAVQIGDSKISRCIVSLLlcnKANVNTRCRLNTTPIFYAINCIDTLKLLLengaDINATSDNDNAV-----IHLATE 268
Cdd:PHA02791 131 SFYHAVMLNDVSIVSYFLSEI---PSTFDLAILLSCIHITIKNGHVDMMILLL----DYMTSTNTNNSLlfipdIKLAID 203
|
170
....*....|....*..
gi 18203040 269 NRRYDIIKTLLDYGADV 285
Cdd:PHA02791 204 NKDLEMLQALFKYDINI 220
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
221-362 |
9.70e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 49.82 E-value: 9.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 221 VNTRCRLNTTPIFYAIN----CIDTLKLLLENGADINATSDNDN--AVIHLAT--ENRRYDIIKTLLDYGADVNMIGYRG 292
Cdd:PHA02859 44 VNDCNDLYETPIFSCLEkdkvNVEILKFLIENGADVNFKTRDNNlsALHHYLSfnKNVEPEILKILIDSGSSITEEDEDG 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18203040 293 KTPLYYATENYSYR--NMKLLLDHGSNPNIADHIMNTPLFISIKCTCIEN-TKMLLDSGADINHVNDNGETPI 362
Cdd:PHA02859 124 KNLLHMYMCNFNVRinVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDKKiFDFLTSLGIDINETNKSGYNCY 196
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
12-181 |
1.84e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 50.26 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 12 HAVSINDRFSVVNILEKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHliamdyyvphndI 91
Cdd:PHA02878 173 HYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH------------I 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 92 KHGHHNDYvfkmvPIINLFLRKKANINACNN-LNQTPLHLAAESNNTtlLKILLYNNAKVNILDIYGNTCLHYAVRGRNI 170
Cdd:PHA02878 241 SVGYCKDY-----DILKLLLEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVKQYLC 313
|
170
....*....|.
gi 18203040 171 ESIKLLLSYNV 181
Cdd:PHA02878 314 INIGRILISNI 324
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
265-378 |
1.18e-05 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 47.71 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 265 LATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSY---RNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENT 341
Cdd:PHA03095 20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDV 99
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 18203040 342 -KMLLDSGADINHVNDNGETPIS-YLA-PNLIPTPVAILV 378
Cdd:PHA03095 100 iKLLIKAGADVNAKDKVGRTPLHvYLSgFNINPKVIRLLL 139
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
239-356 |
1.69e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 47.43 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 239 IDTLKLLLENGADINATSDNDNAVI-HLATENRRYDIIKTLLDYGADVNMIGYRgKTPL------YYATENYSYRNMKLL 311
Cdd:PHA02989 16 KNALEFLLRTGFDVNEEYRGNSILLlYLKRKDVKIKIVKLLIDNGADVNYKGYI-ETPLcavlrnREITSNKIKKIVKLL 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 18203040 312 LDHGSNPNIADHIMNTPLFISIKCTCIENTKML---LDSGADINHVND 356
Cdd:PHA02989 95 LKFGADINLKTFNGVSPIVCFIYNSNINNCDMLrflLSKGINVNDVKN 142
|
|
| PHA02884 |
PHA02884 |
ankyrin repeat protein; Provisional |
272-488 |
1.78e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165212 [Multi-domain] Cd Length: 300 Bit Score: 46.90 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 272 YDIIKTLLDYGADVNMIGYRGK----TPLYYATENYSYRNMKLLLDHGSNPN-IADHIMNTPLFISIKCTCIENTKMLLD 346
Cdd:PHA02884 46 TDIIDAILKLGADPEAPFPLSEnsktNPLIYAIDCDNDDAAKLLIRYGADVNrYAEEAKITPLYISVLHGCLKCLEILLS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 347 SGADINHVNDNGETPIS----------------------YLAPNLIPTPVAIL--VISHIVLLKTKYN----HIKYL-PG 397
Cdd:PHA02884 126 YGADINIQTNDMVTPIElalmicnnflafmicdneisnfYKHPKKILINFDILkiLVSHFILQASNDRlnekHNKNFnAG 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 398 FIKNISVIQNFTKFNNIKKVCEDEFRFMRSVSLSANHNLS----SYICNDNLHTLVRFIKNPKIYYSINKIRIYRNRLYS 473
Cdd:PHA02884 206 YNKNKHLIIQSIILKQFKDLCIDDIDIMKNIKLGDDSNDMlsffDILVENDLIKLLNNIDNIDILDIPKKLKVYNNKIKL 285
|
250
....*....|....*
gi 18203040 474 IIERLLNRKKLHDLV 488
Cdd:PHA02884 286 FLDEAIIYNNINEIL 300
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
236-316 |
3.81e-05 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 44.10 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 236 INCIDTLKLLLENGADINAT-SDNDNAVIHLATENRRYDIIKTLLDY-GADVNMIGYRGKTPLYYATENYSYRNMKLLLD 313
Cdd:PHA02736 68 ADPQEKLKLLMEWGADINGKeRVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRA 147
|
...
gi 18203040 314 HGS 316
Cdd:PHA02736 148 KGA 150
|
|
| PRANC |
pfam09372 |
PRANC domain; This presumed domain is found at the C-terminus of a variety of Pox virus ... |
439-518 |
6.90e-05 |
|
PRANC domain; This presumed domain is found at the C-terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin - C terminal) domain is also found on its own in some proteins. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role.
Pssm-ID: 286461 [Multi-domain] Cd Length: 95 Bit Score: 41.85 E-value: 6.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 439 YICNDNLHTLVRFIKNPKIYYsINKIRIYRNRLYSIIERLLNRKKLHDLVLELIKDI----GVFNKLPLDIISMILDFLS 514
Cdd:pfam09372 9 LFNKNNINILVRYVNNDSLIK-LKSFPIYGDIIKKIIKSSKERYKLINKAIDVLNNIcsnnSLWNLLPIEIKYNILEYLN 87
|
....
gi 18203040 515 DDDL 518
Cdd:pfam09372 88 DDDL 91
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
27-152 |
8.68e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 45.46 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 27 EKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYgicINTRDILGNTALHLIAMDYYVPHNDI------KHGHHNDYV 100
Cdd:TIGR00870 39 EPKKLNINCPDRLGRSALFVAAIENENLELTELLLN---LSCRGAVGDTLLHAISLEYVDAVEAIllhllaAFRKSGPLE 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 18203040 101 FKMVPIINLFLRkkaninacnnlNQTPLHLAAESNNTTLLKILLYNNAKVNI 152
Cdd:TIGR00870 116 LANDQYTSEFTP-----------GITALHLAAHRQNYEIVKLLLERGASVPA 156
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
275-379 |
1.32e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 44.50 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 275 IKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENTKMLL-----DSGA 349
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqcHFEL 177
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 18203040 350 DINHVNDN--------GETPISYLAPNL--IPTPV--AILVI 379
Cdd:PTZ00322 178 GANAKPDSftgkppslEDSPISSHHPDFsaVPQPMmgSLIVI 219
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
239-356 |
3.51e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 43.28 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 239 IDTLKLLLENGADINATSDNDNAVI-----HLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLL- 312
Cdd:PHA02798 51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLf 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 18203040 313 --DHGSNPNIADHIMNTPLFISIKCTC---IENTKMLLDSGADINHVND 356
Cdd:PHA02798 131 miENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINTHNN 179
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
142-198 |
3.80e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 3.80e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 18203040 142 ILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSYNVDVNIRNFTYWySALHEA 198
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL-TALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
156-187 |
4.16e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 4.16e-04
10 20 30
....*....|....*....|....*....|...
gi 18203040 156 YGNTCLHYAV-RGRNIESIKLLLSYNVDVNIRN 187
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
245-319 |
5.20e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 42.73 E-value: 5.20e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18203040 245 LLENGADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYY--ATENYSYRNMKLLLDHGSNPN 319
Cdd:PHA02946 58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYlsGTDDEVIERINLLVQYGAKIN 134
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
111-285 |
5.77e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.55 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 111 LRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIEsiklllsynvdvnIRNFTY 190
Cdd:PLN03192 545 LKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK-------------IFRILY 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 191 WYSALHEAVQIGDskisrcivslLLCNKANVNTrcrlnttpifyaincIDTLKLLLENGADINATSDNDNAVIHLATENR 270
Cdd:PLN03192 612 HFASISDPHAAGD----------LLCTAAKRND---------------LTAMKELLKQGLNVDSEDHQGATALQVAMAED 666
|
170
....*....|....*
gi 18203040 271 RYDIIKTLLDYGADV 285
Cdd:PLN03192 667 HVDMVRLLIMNGADV 681
|
|
| PHA02741 |
PHA02741 |
hypothetical protein; Provisional |
234-311 |
6.97e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 165108 [Multi-domain] Cd Length: 169 Bit Score: 40.41 E-value: 6.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 234 YAINCIDtlkLLLENGADINA-TSDNDNAVIHLATENRRYDIIKTLL-DYGADVNMIGYRGKTPLYYATENYSYRNMKLL 311
Cdd:PHA02741 75 LAAEIID---HLIELGADINAqEMLEGDTALHLAAHRRDHDLAEWLCcQPGIDLHFCNADNKSPFELAIDNEDVAMMQIL 151
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
157-215 |
7.14e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.64 E-value: 7.14e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 18203040 157 GNTCLHYAVRGRNIESIKLLLSYNVDVNIRNfTYWYSALHEAVQIGDSKisrcIVSLLL 215
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVE----VLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
191-331 |
7.31e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 42.31 E-value: 7.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 191 WYSALHEAVQIGDSkisRCIVSLLLCNKANVNTRCRLNTTPIFYAI--NCIDTLKLLLENGAD-IN--ATSD--NDNAVI 263
Cdd:cd22192 17 SESPLLLAAKENDV---QAIKKLLKCPSCDLFQRGALGETALHVAAlyDNLEAAVVLMEAAPElVNepMTSDlyQGETAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 264 HLATENRRYDIIKTLLDYGADV---------------NMIgYRGKTPLYYATENYSYRNMKLLLDHGSNPNIADHIMNTP 328
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspratgtffrpgpkNLI-YYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
|
...
gi 18203040 329 LFI 331
Cdd:cd22192 173 LHI 175
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
115-164 |
9.69e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.33 E-value: 9.69e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 18203040 115 ANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYA 164
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
245-299 |
1.10e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.33 E-value: 1.10e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 18203040 245 LLENG-ADINATSDNDNAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYA 299
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
156-185 |
1.25e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 1.25e-03
10 20 30
....*....|....*....|....*....|
gi 18203040 156 YGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
170-518 |
1.29e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 41.27 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 170 IESIKLLLSYNVDVNIRNFTYW-YSALHEAVQIGDSKISRcIVSLLLCNKANVNTRCRLNTTPIF-----YAINCIDTLK 243
Cdd:PHA02989 50 IKIVKLLIDNGADVNYKGYIETpLCAVLRNREITSNKIKK-IVKLLLKFGADINLKTFNGVSPIVcfiynSNINNCDMLR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 244 LLLENGADINATSDNDN-AVIHLATEN--RRYDIIKTLLDYGADV-NMIGYRGKTP----LYYATENYSYRNMKLLLDHG 315
Cdd:PHA02989 129 FLLSKGINVNDVKNSRGyNLLHMYLESfsVKKDVIKILLSFGVNLfEKTSLYGLTPmniyLRNDIDVISIKVIKYLIKKG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 316 SN--------------------------------------PNIADHIMNTPLFISIKCTCIENTKMLLDSGADINHVNDN 357
Cdd:PHA02989 209 VNietnnngsesvlesfldnnkilskkefkvlnfilkyikINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 358 GETPISYLAPNliptpVAILVISHIVLLKTK--------------------YNHIKYL-------------PGFIKNISV 404
Cdd:PHA02989 289 GDTVLTYAIKH-----GNIDMLNRILQLKPGkylikktfeyfsehgindlfFNEKKMLmmillmqysftiyPIFYKNCYE 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 405 IQnfTKFNNIKKVCEDEFRFMRSVSLSANHNLSSYI-CNDNLHTLVRFIKNPKIYYSINKIrIYRNRLYSIIERLL---- 479
Cdd:PHA02989 364 VR--LAFPNIIERYEKDLLLMKKETVGKNLSVYDLVfNREKEIIPVKFLKNENFLKFKSSI-LYGEKIKQIILNSYeyyn 440
|
410 420 430
....*....|....*....|....*....|....*....
gi 18203040 480 NRKKLHDLVLELIKDIGVFNKLPLDIISMILDFLSDDDL 518
Cdd:PHA02989 441 CLNKAIDVLNKYCNKKNYWMYLPIEIQINILEYLTFSDF 479
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
260-312 |
1.35e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 1.35e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 18203040 260 NAVIHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLL 312
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
42-78 |
1.38e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 1.38e-03
10 20 30
....*....|....*....|....*....|....*..
gi 18203040 42 NPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALH 78
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
236-352 |
1.89e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 40.83 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 236 INCIDTLklllengadinatsdNDNAVIHLATENRRYDIIKTLLDYGADvnmiGYRGKTPLYYATENYsYRNMKLLLDH- 314
Cdd:TIGR00870 45 INCPDRL---------------GRSALFVAAIENENLELTELLLNLSCR----GAVGDTLLHAISLEY-VDAVEAILLHl 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 18203040 315 ------GSNPNIADHIMN-------TPLFISIKCTCIENTKMLLDSGADIN 352
Cdd:TIGR00870 105 laafrkSGPLELANDQYTseftpgiTALHLAAHRQNYEIVKLLLERGASVP 155
|
|
| PHA02743 |
PHA02743 |
Viral ankyrin protein; Provisional |
237-315 |
2.67e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 222925 [Multi-domain] Cd Length: 166 Bit Score: 38.64 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 237 NCIDTLKLLLENGADINATSDN-DNAVIHLATENRRYDIIKTLL-DYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDH 314
Cdd:PHA02743 71 NAVMKIELLVNMGADINARELGtGNTLLHIAASTKNYELAEWLCrQLGVNLGAINYQHETAYHIAYKMRDRRMMEILRAN 150
|
.
gi 18203040 315 G 315
Cdd:PHA02743 151 G 151
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
107-179 |
3.40e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 40.27 E-value: 3.40e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18203040 107 INLFLRKKANINACNNLNQTPLHLAAESNNTTLLKILLYNNAKVNILDIYGNTCLHYAVRGRNIESIKLLLSY 179
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
23-81 |
4.52e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 39.65 E-value: 4.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 18203040 23 VNILEKKNIPIDYINFHPDNPLLEAVKLTNTDMIKTLLDYGICINTRDILGNTALHLIA 81
Cdd:PHA03100 175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
146-363 |
6.41e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 39.12 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 146 NNAKVNILDIYGNTclhYAVRGRNIESIKLLLSYN-VDVNIRNFTYWYSALHeaVQIGDSKISRCIVSLLLCNKANVNTR 224
Cdd:PHA02716 134 NNGDMDILYTYFNS---PNTRGIDLDLIKYMVDVGiVNLNYVCKKTGYGILH--AYLGNMYVDIDILEWLCNNGVNVNLQ 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 225 CRLNTTPIF-YAIN---CIDTLKLLLENGADIN--------------ATSDNDNA--------------------VIHLA 266
Cdd:PHA02716 209 NNHLITPLHtYLITgnvCASVIKKIIELGGDMDmkcvngmspimtyiINIDNINPeitniyiesldgnkvknipmILHSY 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 267 TENRRY---DIIKTLLDYGADVNMIGYRGKTPL--YYATENYSYRNMKLLLDHGSNPNIADHIMNTPLFISIKCTCIENT 341
Cdd:PHA02716 289 ITLARNidiSVVYSFLQPGVKLHYKDSAGRTCLhqYILRHNISTDIIKLLHEYGNDLNEPDNIGNTVLHTYLSMLSVVNI 368
|
250 260 270
....*....|....*....|....*....|....*.
gi 18203040 342 --------------KMLLDSGADINHVNDNGETPIS 363
Cdd:PHA02716 369 ldpetdndirldviQCLISLGADITAVNCLGYTPLT 404
|
|
| PHA02792 |
PHA02792 |
ankyrin-like protein; Provisional |
245-512 |
6.61e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165155 [Multi-domain] Cd Length: 631 Bit Score: 39.16 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 245 LLENGADInaTSDNDNAV-------IHLATENRRYDIIKTLLDYGADVNMIGYRGKTPLYYATENYSYRNMKLLLDHGSN 317
Cdd:PHA02792 358 ILKNGNVV--VEDDDNIInimplfpTLSIHESDVLSILKLCKPYIDDINKIDKHGRSILYYCIESHSVSLVEWLIDNGAD 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 318 PNIADHIMNT-----------------PLFISI------KCTCIENTKMLLDSGADINHVNdngetpISYLAPNLIPtpv 374
Cdd:PHA02792 436 INITTKYGSTcigicvilahacipeiaELYIKIleiilsKLPTIECIKKTVDYLSNDRYLL------IGNKNKSLLK--- 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 375 aiLVISHIVLLKTKYNHIKYlPGFIKNISviqnftkfnnikkVCEDEFRFMRSVSLSANhNLSSYICNDNLHTLVRFIKN 454
Cdd:PHA02792 507 --ICIKYFILVDYKYTCDMY-PSYIEYIT-------------DCEKEIADMRQIKINGT-DMLTVMYKLNKPTKKRYVNN 569
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 18203040 455 PK-IYYSINKIRIYRNRLYSIIERLLNRKKLHDLVLELIKDIGVFNKLPLDIISMILDF 512
Cdd:PHA02792 570 PVfTEWAKKQYKFYNQIIYNANKLIEQSKKIDNMIDEVSADNNRLSTLPLELRHLIFSY 628
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
156-185 |
7.78e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 34.16 E-value: 7.78e-03
10 20 30
....*....|....*....|....*....|
gi 18203040 156 YGNTCLHYAVRGRNIESIKLLLSYNVDVNI 185
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
157-264 |
9.08e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 38.71 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18203040 157 GNTCLHYAVRGRN---IESIKLLLSYNVD-------VNIRNFTYWY---SALHEAVQigdsKISRCIVSLLLCNKANVNT 223
Cdd:cd21882 26 GKTCLHKAALNLNdgvNEAIMLLLEAAPDsgnpkelVNAPCTDEFYqgqTALHIAIE----NRNLNLVRLLVENGADVSA 101
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 18203040 224 RC-----RLNTTPIFY----------AINCIDTLKLLLENGADINATSDND---NAVIH 264
Cdd:cd21882 102 RAtgrffRKSPGNLFYfgelplslaaCTNQEEIVRLLLENGAQPAALEAQDslgNTVLH 160
|
|
| |
