|
Name |
Accession |
Description |
Interval |
E-value |
| IFR3_antag super family |
cl20679 |
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ... |
1-249 |
2.07e-175 |
|
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.
The actual alignment was detected with superfamily member pfam14754:
Pssm-ID: 291424 Cd Length: 249 Bit Score: 528.08 E-value: 2.07e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1 MATFSATGFGGSFVRDWSLDLPAACEHGAGLCCEVDGSTLCAECFRGCEGVEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754 1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANPWVVSPAANSLVVTIDQEQ 160
Cdd:pfam14754 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINSSSGELKFHIMRSSPQRAWHITTRSCKLKS 240
Cdd:pfam14754 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
|
....*....
gi 1812779142 241 YYVCDISEA 249
Cdd:pfam14754 241 YYVCDISEA 249
|
|
| Peptidase_S32 super family |
cl21733 |
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ... |
963-1269 |
1.47e-138 |
|
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.
The actual alignment was detected with superfamily member pfam05579:
Pssm-ID: 253263 Cd Length: 297 Bit Score: 430.74 E-value: 1.47e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 963 LATLFVNLFfpqatLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARTAGQSReqmlrVSAAAPANSLLGV 1041
Cdd:pfam05579 1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWSRNNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579 71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1122 LTFKKNGDFAEAVTtqSELPGNWPQLNYAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGVHTG 1200
Cdd:pfam05579 150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLSPIPK-DIPDNIIADVDAVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579 228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
|
|
| Nsp2_AV |
pfam14755 |
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ... |
361-508 |
8.66e-90 |
|
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.
:
Pssm-ID: 373271 [Multi-domain] Cd Length: 148 Bit Score: 288.03 E-value: 8.66e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 361 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPTPAP 440
Cdd:pfam14755 1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1812779142 441 RMRPQDAAKQEPPADTAAAPASAPRWRVAKTVYSSAGRIRTELIHRAQSIGDSLVQALPLKTPAVQRY 508
Cdd:pfam14755 81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
|
|
| Arteri_nsp7a |
pfam16749 |
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ... |
1454-1573 |
1.43e-45 |
|
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.
:
Pssm-ID: 374774 Cd Length: 128 Bit Score: 160.65 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1454 LTATLA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQVDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749 1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1812779142 1531 AGDRVVVIdGLDHMAHFK------GDLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749 81 PGDPVVLL-GKTPVGEIFdiyvgdTKHVLRPIETRVVAGSKCTICTVVV 128
|
|
| av_Nsp3_ER-remodelling |
cd22528 |
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ... |
846-902 |
1.11e-22 |
|
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.
:
Pssm-ID: 412095 Cd Length: 57 Bit Score: 92.77 E-value: 1.11e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1812779142 846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASADGISLDTLGLTQLQS 902
Cdd:cd22528 1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
|
|
| Peptidase_C33 super family |
cl05135 |
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ... |
261-357 |
3.56e-14 |
|
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.
The actual alignment was detected with superfamily member pfam05412:
Pssm-ID: 114153 Cd Length: 108 Bit Score: 70.33 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNARYVMICDKQH 332
Cdd:pfam05412 1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
|
90 100
....*....|....*....|....*.
gi 1812779142 333 WRVKRAKGVGL-CLDENCFRGTCDCQ 357
Cdd:pfam05412 80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| IFR3_antag |
pfam14754 |
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ... |
1-249 |
2.07e-175 |
|
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.
Pssm-ID: 291424 Cd Length: 249 Bit Score: 528.08 E-value: 2.07e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1 MATFSATGFGGSFVRDWSLDLPAACEHGAGLCCEVDGSTLCAECFRGCEGVEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754 1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANPWVVSPAANSLVVTIDQEQ 160
Cdd:pfam14754 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINSSSGELKFHIMRSSPQRAWHITTRSCKLKS 240
Cdd:pfam14754 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
|
....*....
gi 1812779142 241 YYVCDISEA 249
Cdd:pfam14754 241 YYVCDISEA 249
|
|
| Peptidase_S32 |
pfam05579 |
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ... |
963-1269 |
1.47e-138 |
|
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.
Pssm-ID: 253263 Cd Length: 297 Bit Score: 430.74 E-value: 1.47e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 963 LATLFVNLFfpqatLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARTAGQSReqmlrVSAAAPANSLLGV 1041
Cdd:pfam05579 1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWSRNNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579 71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1122 LTFKKNGDFAEAVTtqSELPGNWPQLNYAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGVHTG 1200
Cdd:pfam05579 150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLSPIPK-DIPDNIIADVDAVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579 228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
|
|
| Nsp2_AV |
pfam14755 |
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ... |
361-508 |
8.66e-90 |
|
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.
Pssm-ID: 373271 [Multi-domain] Cd Length: 148 Bit Score: 288.03 E-value: 8.66e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 361 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPTPAP 440
Cdd:pfam14755 1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1812779142 441 RMRPQDAAKQEPPADTAAAPASAPRWRVAKTVYSSAGRIRTELIHRAQSIGDSLVQALPLKTPAVQRY 508
Cdd:pfam14755 81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
|
|
| Arteri_nsp7a |
pfam16749 |
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ... |
1454-1573 |
1.43e-45 |
|
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.
Pssm-ID: 374774 Cd Length: 128 Bit Score: 160.65 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1454 LTATLA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQVDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749 1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1812779142 1531 AGDRVVVIdGLDHMAHFK------GDLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749 81 PGDPVVLL-GKTPVGEIFdiyvgdTKHVLRPIETRVVAGSKCTICTVVV 128
|
|
| av_Nsp3_ER-remodelling |
cd22528 |
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ... |
846-902 |
1.11e-22 |
|
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.
Pssm-ID: 412095 Cd Length: 57 Bit Score: 92.77 E-value: 1.11e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1812779142 846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASADGISLDTLGLTQLQS 902
Cdd:cd22528 1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
|
|
| Peptidase_C33 |
pfam05412 |
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ... |
261-357 |
3.56e-14 |
|
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.
Pssm-ID: 114153 Cd Length: 108 Bit Score: 70.33 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNARYVMICDKQH 332
Cdd:pfam05412 1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
|
90 100
....*....|....*....|....*.
gi 1812779142 333 WRVKRAKGVGL-CLDENCFRGTCDCQ 357
Cdd:pfam05412 80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
358-447 |
4.50e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.06 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 358 RRSGPPPAPVSASVLDHILEAATFGNVRVVATEEQ-QRPVPAP-RTRPSASPPGNVEDTETVP-PVPKPRTKLAKPSPAQ 434
Cdd:PHA03378 699 RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRaRPPAAAPgRARPPAAAPGRARPPAAAPgRARPPAAAPGAPTPQP 778
|
90
....*....|....*
gi 1812779142 435 APT--PAPRMRPQDA 447
Cdd:PHA03378 779 PPQapPAPQQRPRGA 793
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| IFR3_antag |
pfam14754 |
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine ... |
1-249 |
2.07e-175 |
|
Papain-like auto-proteinase; The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase pfam05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.
Pssm-ID: 291424 Cd Length: 249 Bit Score: 528.08 E-value: 2.07e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1 MATFSATGFGGSFVRDWSLDLPAACEHGAGLCCEVDGSTLCAECFRGCEGVEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
Cdd:pfam14754 1 MATFSATGFGGSFVRDWSLDLPDACEHGAGLCCEVDGSTLCAECFRGCEGMEQCPGLFMGLLKLASPVPVGHKFLIGWYR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANPWVVSPAANSLVVTIDQEQ 160
Cdd:pfam14754 81 AAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTPVYANAWVVSPAANSLIVTTDQEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINSSSGELKFHIMRSSPQRAWHITTRSCKLKS 240
Cdd:pfam14754 161 DGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGGLKFHIMRGSPQRAWHITTRSCKLKS 240
|
....*....
gi 1812779142 241 YYVCDISEA 249
Cdd:pfam14754 241 YYVCDISEA 249
|
|
| Peptidase_S32 |
pfam05579 |
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing ... |
963-1269 |
1.47e-138 |
|
Equine arteritis virus serine endopeptidase S32; Serine peptidases involved in processing nidovirus polyprotein.
Pssm-ID: 253263 Cd Length: 297 Bit Score: 430.74 E-value: 1.47e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 963 LATLFVNLFfpqatLVTMGYWACVAALAVYSLMGLRVK-VNVPMCVTPAHFLLLARTAGQSReqmlrVSAAAPANSLLGV 1041
Cdd:pfam05579 1 LTMLWVQFF-----LVFVNFWAGVAALVVLISLWLLARyTNVAGLVTPYDIHLVTSSPRGAA-----ALATAPEGTYLAA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1042 ARDCYVTGTTRLYIPKEGGMVFEGLFRSPKARGNVGFVAGSSYGTGSVWSRNNEVVVLTASHVVGrANMATLKIGDTMLT 1121
Cdd:pfam05579 71 VRRAALTGRTCLFVPSNFGSVLEGLFRTRKPALNVVSVFGSSSGSGGVFTINGNVVVVTASHVLG-GNKARVSGVGFNQM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1122 LTFKKNGDFAEAVTtqSELPGNWPQLNYAQPTTGPASWCTATGDEEGLLSGEVCLAWTTSGDSGSAVVQGDA-VVGVHTG 1200
Cdd:pfam05579 150 LTFKTNGDYAFAVV--AEWPGAAPKLKFAQGYTGRAYWSTSTGVEPGLLGKGFAFCFTKCGDSGSPVITEDGnLVGVHTG 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1201 SNTSGVAYVTTPSGKLLGADTVTLSSLSKHFTGPLSPIPK-DIPDNIIADVDAVPRSLAMLIDGLSNRES 1269
Cdd:pfam05579 228 SNKRGSGMVTTPSGKTLGMAPVKLSELSKHFAGPGVPVPTvKLPKNIIVDVEAVPSDLAALLESLPNLEG 297
|
|
| Nsp2_AV |
pfam14755 |
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, ... |
361-508 |
8.66e-90 |
|
Nsp2, transmembrane domain; This domain is found in Nsp2 protein of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, which is a tetraspanning transmembrane protein. This domain resides adjacent to the peptidase C33 catalytic domain of Nsp2.
Pssm-ID: 373271 [Multi-domain] Cd Length: 148 Bit Score: 288.03 E-value: 8.66e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 361 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPTPAP 440
Cdd:pfam14755 1 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRTRPSASSSGDVKDPATVPPVPKPRTKLAKPSPTQAPTPAP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1812779142 441 RMRPQDAAKQEPPADTAAAPASAPRWRVAKTVYSSAGRIRTELIHRAQSIGDSLVQALPLKTPAVQRY 508
Cdd:pfam14755 81 RTRLQDASKQEPPVGTAAAPASAPKWRVAKTVYSSAERIRTELVQRARSIGDVLVQALPLKTPAVQRY 148
|
|
| Arteri_nsp7a |
pfam16749 |
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a ... |
1454-1573 |
1.43e-45 |
|
Arterivirus nonstructural protein 7 alpha; Nonstructural protein 7 alpha is likely to have a role in viral RNA synthesis.
Pssm-ID: 374774 Cd Length: 128 Bit Score: 160.65 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 1454 LTATLA-ALTDDDFQFLSDVLDCRAVRSAMNLRAALTSFQVAQYRNILNASLQVDRDAARSRRLMAKLADFA--VEQEVT 1530
Cdd:pfam16749 1 LTAALAcALSDDDLDFLSQLVDCKAFVSASNMRNALGDFIESAYAKALRASLASVVAVAKSRRALAKLEDFAdtVSPQLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1812779142 1531 AGDRVVVIdGLDHMAHFK------GDLVLVPLTTKVVGGSRCTICDVVK 1573
Cdd:pfam16749 81 PGDPVVLL-GKTPVGEIFdiyvgdTKHVLRPIETRVVAGSKCTICTVVV 128
|
|
| av_Nsp3_ER-remodelling |
cd22528 |
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This ... |
846-902 |
1.11e-22 |
|
intracellular membrane remodeller motif of arterivirus non-structural protein 3 (Nsp3); This domain is present in subunit Nsp3 of RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV. Nsp3 proteins are localized to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus. Arterivirus Nsp3 is a predicted tetra-spanning transmembrane protein containing four transmembrane helices, with the N- and C-termini of the protein residing in the cytoplasm. It contains a cluster of four highly conserved cysteine residues that are predicted to reside in the first luminal domain of the protein. These conserved cysteines play a key role in the formation of double-membrane vesicles (DMVs); mutagenesis of each completely blocked DMV formation.
Pssm-ID: 412095 Cd Length: 57 Bit Score: 92.77 E-value: 1.11e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1812779142 846 STFTCLPIKCGIGTRDPFCRRVFSVPVTKTQEHCHAGMCASADGISLDTLGLTQLQS 902
Cdd:cd22528 1 GLYLQSPVSCGIGTNDPFCRNPFGVPVVGTQGVCHSGYCASAQGISLPTSLLTQLSS 57
|
|
| Peptidase_C33 |
pfam05412 |
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These ... |
261-357 |
3.56e-14 |
|
Equine arterivirus Nsp2-type cysteine proteinase; Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.
Pssm-ID: 114153 Cd Length: 108 Bit Score: 70.33 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 261 GYNPPGDGACGYRCLAFMNGATAVSAGCS--------SDLWCDDELAYRVFQLSpTFTVTIPGGRVCPNARYVMICDKQH 332
Cdd:pfam05412 1 GYSPPGDGACGWHCISAIANRMFNDKFTTtltecsrpSDDWASDQDLVQAIQTL-RLPATLDRNGACPSAKYKLKLVGQH 79
|
90 100
....*....|....*....|....*.
gi 1812779142 333 WRVKRAKGVGL-CLDENCFRGTCDCQ 357
Cdd:pfam05412 80 WTVTVRKGMAPgLLSPECVRGVCGHE 105
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
358-447 |
4.50e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.06 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 358 RRSGPPPAPVSASVLDHILEAATFGNVRVVATEEQ-QRPVPAP-RTRPSASPPGNVEDTETVP-PVPKPRTKLAKPSPAQ 434
Cdd:PHA03378 699 RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRaRPPAAAPgRARPPAAAPGRARPPAAAPgRARPPAAAPGAPTPQP 778
|
90
....*....|....*
gi 1812779142 435 APT--PAPRMRPQDA 447
Cdd:PHA03378 779 PPQapPAPQQRPRGA 793
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
358-448 |
1.23e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 358 RRSGPPPAPVSASvldhilEAATFGNVRVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPT 437
Cdd:PRK07764 400 SAAAAAPAAAPAP------AAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAA 473
|
90
....*....|.
gi 1812779142 438 PAPRMRPQDAA 448
Cdd:PRK07764 474 PEPTAAPAPAP 484
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
361-444 |
1.82e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 361 GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPA--PRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPTP 438
Cdd:PHA03307 127 PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASdaASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRP 206
|
....*.
gi 1812779142 439 APRMRP 444
Cdd:PHA03307 207 PRRSSP 212
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
358-445 |
1.89e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 358 RRSGPPPAPVSASVldhileAATFGNVRVVAteeqqRPVPAPRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQaPT 437
Cdd:PHA03247 2863 RRRPPSRSPAAKPA------APARPPVRRLA-----RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-PQ 2930
|
....*...
gi 1812779142 438 PAPRMRPQ 445
Cdd:PHA03247 2931 PPPPPPPR 2938
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
358-444 |
4.19e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1812779142 358 RRSGPPPAPVSASvldhiLEAATFGNVRVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPkprtklakPSPAQAPT 437
Cdd:PRK12323 424 ARRSPAPEALAAA-----RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPAR--------AAPAAAPA 490
|
....*..
gi 1812779142 438 PAPRMRP 444
Cdd:PRK12323 491 PADDDPP 497
|
|
| DUF6264 |
pfam19779 |
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ... |
388-444 |
7.00e-03 |
|
Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.
Pssm-ID: 466182 Cd Length: 182 Bit Score: 39.56 E-value: 7.00e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1812779142 388 ATEEQQRPVPA--PRTRPSASPPGNVEDTETVPPVPKPRTKLAKPSPAQAPTPAPRMRP 444
Cdd:pfam19779 8 APPGWQRAPIGdpAAAAAAAPPAAPAPAAPAPPAAPAAPPAAPPPPGAPAPGAPAAARR 66
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
388-451 |
8.16e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 39.99 E-value: 8.16e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1812779142 388 ATEEQQRPVPAPRTRPSASPPGNV----EDTETVPPVPKPRTK-LAKPSPAQAPTPAPRMRPQDAAKQE 451
Cdd:PRK11633 72 AEAVRAGDAAAPSLDPATVAPPNTpvepEPAPVEPPKPKPVEKpKPKPKPQQKVEAPPAPKPEPKPVVE 140
|
|
| PRK12757 |
PRK12757 |
cell division protein FtsN; Provisional |
385-450 |
8.49e-03 |
|
cell division protein FtsN; Provisional
Pssm-ID: 237191 [Multi-domain] Cd Length: 256 Bit Score: 40.03 E-value: 8.49e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1812779142 385 RVVATEEQQRPVPAPRTRPSASPPGNVEDTETVPPVPKPR--TKLAKPSPAQAPTPAPRMRPQDAAKQ 450
Cdd:PRK12757 116 RSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPapVRTQPAAPVTQAVEAPKVEAEKEKEQ 183
|
|
| |
