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Conserved domains on  [gi|1811711706|gb|KAF2774566|]
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P-loop containing nucleoside triphosphate hydrolase protein [Teratosphaeria nubilosa]

Protein Classification

signal recognition particle receptor subunit beta( domain architecture ID 10134869)

signal recognition particle (SRP) receptor subunit beta, together with SRP subunit alpha, forms the heterodimeric SRP receptor that binds SRP to regulate protein translocation across the ER membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_beta cd04105
Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms ...
 48-288 1.21e-50

Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP); Signal recognition particle receptor, beta subunit (SR-beta). SR-beta and SR-alpha form the heterodimeric signal recognition particle (SRP or SR) receptor that binds SRP to regulate protein translocation across the ER membrane. Nascent polypeptide chains are synthesized with an N-terminal hydrophobic signal sequence that binds SRP54, a component of the SRP. SRP directs targeting of the ribosome-nascent chain complex (RNC) to the ER membrane via interaction with the SR, which is localized to the ER membrane. The RNC is then transferred to the protein-conducting channel, or translocon, which facilitates polypeptide translation across the ER membrane or integration into the ER membrane. SR-beta is found only in eukaryotes; it is believed to control the release of the signal sequence from SRP54 upon binding of the ribosome to the translocon. High expression of SR-beta has been observed in human colon cancer, suggesting it may play a role in the development of this type of cancer.


:

Pssm-ID: 206691 [Multi-domain]  Cd Length: 202  Bit Score: 165.57  E-value: 1.21e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  48 PTVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAVCQLPASTKAredryrcendttsrarpKFLLLDTPGHGKLRDH 127
Cdd:cd04105     1 PTVLLLGPSDSGKTALFTKLTTGKVRSTVTSIEPNVASFYSNSSKGK-----------------KLTLVDVPGHEKLRDK 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 GFLPLRGerALKGLVFMVDSAAVSsvTGLIEAAEYLHDVLLLLQKRHTQgktskttsVPVLVAANKQDVFTSLPANLVQS 207
Cdd:cd04105    64 LLEYLKA--SLKAIVFVVDSATFQ--KNIRDVAEFLYDILTDLEKIKNK--------IPILIACNKQDLFTAKPAKKIKE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 208 KLEQEIAKVRQTRSKGLldSGIGMDDGAGGDeeaswLGEYGAKDFKFAQMEehgVDIKVLGGNVKDGEqaGKVDEWWDWI 287
Cdd:cd04105   132 LLEKEINTLRESRSKSL--ESLDGDDGSKDT-----LGDKGGKDFEFDQLE---GEVDFVEGSVKKSK--GGIDDIEEWI 199


                  .
gi 1811711706 288 G 288
Cdd:cd04105   200 D 200
 
Name Accession Description Interval E-value
SR_beta cd04105
Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms ...
 48-288 1.21e-50

Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP); Signal recognition particle receptor, beta subunit (SR-beta). SR-beta and SR-alpha form the heterodimeric signal recognition particle (SRP or SR) receptor that binds SRP to regulate protein translocation across the ER membrane. Nascent polypeptide chains are synthesized with an N-terminal hydrophobic signal sequence that binds SRP54, a component of the SRP. SRP directs targeting of the ribosome-nascent chain complex (RNC) to the ER membrane via interaction with the SR, which is localized to the ER membrane. The RNC is then transferred to the protein-conducting channel, or translocon, which facilitates polypeptide translation across the ER membrane or integration into the ER membrane. SR-beta is found only in eukaryotes; it is believed to control the release of the signal sequence from SRP54 upon binding of the ribosome to the translocon. High expression of SR-beta has been observed in human colon cancer, suggesting it may play a role in the development of this type of cancer.


Pssm-ID: 206691 [Multi-domain]  Cd Length: 202  Bit Score: 165.57  E-value: 1.21e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  48 PTVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAVCQLPASTKAredryrcendttsrarpKFLLLDTPGHGKLRDH 127
Cdd:cd04105     1 PTVLLLGPSDSGKTALFTKLTTGKVRSTVTSIEPNVASFYSNSSKGK-----------------KLTLVDVPGHEKLRDK 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 GFLPLRGerALKGLVFMVDSAAVSsvTGLIEAAEYLHDVLLLLQKRHTQgktskttsVPVLVAANKQDVFTSLPANLVQS 207
Cdd:cd04105    64 LLEYLKA--SLKAIVFVVDSATFQ--KNIRDVAEFLYDILTDLEKIKNK--------IPILIACNKQDLFTAKPAKKIKE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 208 KLEQEIAKVRQTRSKGLldSGIGMDDGAGGDeeaswLGEYGAKDFKFAQMEehgVDIKVLGGNVKDGEqaGKVDEWWDWI 287
Cdd:cd04105   132 LLEKEINTLRESRSKSL--ESLDGDDGSKDT-----LGDKGGKDFEFDQLE---GEVDFVEGSVKKSK--GGIDDIEEWI 199


                  .
gi 1811711706 288 G 288
Cdd:cd04105   200 D 200
SRPRB pfam09439
Signal recognition particle receptor beta subunit; The beta subunit of the signal recognition ...
 48-258 5.02e-38

Signal recognition particle receptor beta subunit; The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane.


Pssm-ID: 462797 [Multi-domain]  Cd Length: 181  Bit Score: 132.57  E-value: 5.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  48 PTVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAvcqlpastkareDRYRCENDTtsrarpKFLLLDTPGHGKLRDH 127
Cdd:pfam09439   4 PAVIIAGLCDSGKTSLFTLLTTDSVRPTVTSQEPSAA------------YRYMLNKGN------SFTLIDFPGHVKLRYK 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 GFLPLRGERALKGLVFMVDSAAVSSvtGLIEAAEYLHDVLLLLQKRhtqgktskTTSVPVLVAANKQDVFTSLPANLVQS 207
Cdd:pfam09439  66 LLETLKDSSSLKGIVFVVDSTIFPK--EVTDTAEFLYDILSITELL--------KNGIDILIACNKQESFTARPPKKIKQ 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1811711706 208 KLEQEIAKVRQTRSKGLldsgIGMDdgaGGDEEASWLGEYGaKDFKFAQME 258
Cdd:pfam09439 136 ALEKEINTIRERRSKAL----SGLD---GSEDLSAVLGKKG-KGFKFDQLE 178
YeeP COG3596
Predicted GTPase [General function prediction only];
40-122 2.40e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 48.22  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  40 RKAVAQELPTVLLVGPSGAGKTSLL-TLFanGAPSATHTSQEPQTAVCQlpastkaredRYRCENDTTSRARpkflLLDT 118
Cdd:COG3596    32 RLLVELPPPVIALVGKTGAGKSSLInALF--GAEVAEVGVGRPCTREIQ----------RYRLESDGLPGLV----LLDT 95


                  ....
gi 1811711706 119 PGHG 122
Cdd:COG3596    96 PGLG 99
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 49-143 2.02e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706   49 TVLLVGPSGAGKTSLLTLFANGAPSA----------THTSQEPQTAVCQLPASTKAREDRYRCENDTTSRAR---PKFLL 115
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPgggviyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARklkPDVLI 83

                           90       100
                   ....*....|....*....|....*...
gi 1811711706  116 LDTPGHGKLRDHGFLPLRGERALKGLVF 143
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLL 111
 
Name Accession Description Interval E-value
SR_beta cd04105
Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms ...
 48-288 1.21e-50

Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP); Signal recognition particle receptor, beta subunit (SR-beta). SR-beta and SR-alpha form the heterodimeric signal recognition particle (SRP or SR) receptor that binds SRP to regulate protein translocation across the ER membrane. Nascent polypeptide chains are synthesized with an N-terminal hydrophobic signal sequence that binds SRP54, a component of the SRP. SRP directs targeting of the ribosome-nascent chain complex (RNC) to the ER membrane via interaction with the SR, which is localized to the ER membrane. The RNC is then transferred to the protein-conducting channel, or translocon, which facilitates polypeptide translation across the ER membrane or integration into the ER membrane. SR-beta is found only in eukaryotes; it is believed to control the release of the signal sequence from SRP54 upon binding of the ribosome to the translocon. High expression of SR-beta has been observed in human colon cancer, suggesting it may play a role in the development of this type of cancer.


Pssm-ID: 206691 [Multi-domain]  Cd Length: 202  Bit Score: 165.57  E-value: 1.21e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  48 PTVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAVCQLPASTKAredryrcendttsrarpKFLLLDTPGHGKLRDH 127
Cdd:cd04105     1 PTVLLLGPSDSGKTALFTKLTTGKVRSTVTSIEPNVASFYSNSSKGK-----------------KLTLVDVPGHEKLRDK 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 GFLPLRGerALKGLVFMVDSAAVSsvTGLIEAAEYLHDVLLLLQKRHTQgktskttsVPVLVAANKQDVFTSLPANLVQS 207
Cdd:cd04105    64 LLEYLKA--SLKAIVFVVDSATFQ--KNIRDVAEFLYDILTDLEKIKNK--------IPILIACNKQDLFTAKPAKKIKE 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 208 KLEQEIAKVRQTRSKGLldSGIGMDDGAGGDeeaswLGEYGAKDFKFAQMEehgVDIKVLGGNVKDGEqaGKVDEWWDWI 287
Cdd:cd04105   132 LLEKEINTLRESRSKSL--ESLDGDDGSKDT-----LGDKGGKDFEFDQLE---GEVDFVEGSVKKSK--GGIDDIEEWI 199


                  .
gi 1811711706 288 G 288
Cdd:cd04105   200 D 200
SRPRB pfam09439
Signal recognition particle receptor beta subunit; The beta subunit of the signal recognition ...
 48-258 5.02e-38

Signal recognition particle receptor beta subunit; The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane.


Pssm-ID: 462797 [Multi-domain]  Cd Length: 181  Bit Score: 132.57  E-value: 5.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  48 PTVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAvcqlpastkareDRYRCENDTtsrarpKFLLLDTPGHGKLRDH 127
Cdd:pfam09439   4 PAVIIAGLCDSGKTSLFTLLTTDSVRPTVTSQEPSAA------------YRYMLNKGN------SFTLIDFPGHVKLRYK 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 GFLPLRGERALKGLVFMVDSAAVSSvtGLIEAAEYLHDVLLLLQKRhtqgktskTTSVPVLVAANKQDVFTSLPANLVQS 207
Cdd:pfam09439  66 LLETLKDSSSLKGIVFVVDSTIFPK--EVTDTAEFLYDILSITELL--------KNGIDILIACNKQESFTARPPKKIKQ 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1811711706 208 KLEQEIAKVRQTRSKGLldsgIGMDdgaGGDEEASWLGEYGaKDFKFAQME 258
Cdd:pfam09439 136 ALEKEINTIRERRSKAL----SGLD---GSEDLSAVLGKKG-KGFKFDQLE 178
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 51-195 1.37e-09

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 55.93  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  51 LLVGPSGAGKTSLLTLFANGAPSAthTSQEPQTavcqlpasTKArEDRYRCENDTTSRarpKFLLLDTPGHGKLRDHGFL 130
Cdd:cd00882     1 VVVGRGGVGKSSLLNALLGGEVGE--VSDVPGT--------TRD-PDVYVKELDKGKV---KLVLVDTPGLDEFGGLGRE 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811711706 131 PLRgERALK---GLVFMVDsaavSSVTGLIEAAEYLHDVLLLLQKrhtqgktskttsVPVLVAANKQD 195
Cdd:cd00882    67 ELA-RLLLRgadLILLVVD----STDRESEEDAKLLILRRLRKEG------------IPIILVGNKID 117
Arl2l1_Arl13_like cd04161
Arl2-like protein 1 (Arl2l1) and Arl13; Arl2l1 (Arl2-like protein 1) and Arl13 form a ...
 49-221 4.39e-08

Arl2-like protein 1 (Arl2l1) and Arl13; Arl2l1 (Arl2-like protein 1) and Arl13 form a subfamily of the Arf family of small GTPases. Arl2l1 was identified in human cells during a search for the gene(s) responsible for Bardet-Biedl syndrome (BBS). Like Arl6, the identified BBS gene, Arl2l1 is proposed to have cilia-specific functions. Arl13 is found on the X chromosome, but its expression has not been confirmed; it may be a pseudogene.


Pssm-ID: 133361 [Multi-domain]  Cd Length: 167  Bit Score: 51.62  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  49 TVLLVGPSGAGKTSLLTLFANGAPSATHTSQEPqtavcqlpASTKAREDRYR-CENDTTSRARpkfllldtpGHGKLRDH 127
Cdd:cd04161     1 TLLTVGLDNAGKTTLVSALQGEIPKKVAPTVGF--------TPTKLRLDKYEvCIFDLGGGAN---------FRGIWVNY 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 gflplRGEraLKGLVFMVDSAAVSSVTgliEAAEYLHDvllLLQKRHTQGKtskttsvPVLVAANKQDVFTSL-PANLVQ 206
Cdd:cd04161    64 -----YAE--AHGLVFVVDSSDDDRVQ---EVKEILRE---LLQHPRVSGK-------PILVLANKQDKKNALlGADVIE 123

                         170
                  ....*....|....*
gi 1811711706 207 SKLEQEIakVRQTRS 221
Cdd:cd04161   124 YLSLEKL--VNENKS 136
Arf_Arl cd00878
ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases; Arf (ADP-ribosylation factor)/Arl ...
 50-244 8.62e-07

ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases; Arf (ADP-ribosylation factor)/Arl (Arf-like) small GTPases. Arf proteins are activators of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. Arfs are N-terminally myristoylated. Members of the Arf family are regulators of vesicle formation in intracellular traffic that interact reversibly with membranes of the secretory and endocytic compartments in a GTP-dependent manner. They depart from other small GTP-binding proteins by a unique structural device, interswitch toggle, that implements front-back communication from N-terminus to the nucleotide binding site. Arf-like (Arl) proteins are close relatives of the Arf, but only Arl1 has been shown to function in membrane traffic like the Arf proteins. Arl2 has an unrelated function in the folding of native tubulin, and Arl4 may function in the nucleus. Most other Arf family proteins are so far relatively poorly characterized. Thus, despite their significant sequence homologies, Arf family proteins may regulate unrelated functions.


Pssm-ID: 206644 [Multi-domain]  Cd Length: 158  Bit Score: 47.96  E-value: 8.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  50 VLLVGPSGAGKTSLLTLFANGAPSATHTsqepqTAVCQLPAST-KARedryrcendttsrarpKFLLLDTPGHGKLR--- 125
Cdd:cd00878     2 ILMLGLDGAGKTTILYKLKLGEVVTTIP-----TIGFNVETVEyKNV----------------KFTVWDVGGQDKIRplw 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 126 DHGFlplrgeRALKGLVFMVDSaavSSVTGLIEAAEYLHDVLlllqkRHTQGKTskttsVPVLVAANKQDVFTSLPANLV 205
Cdd:cd00878    61 KHYY------ENTDGLIFVVDS---SDRERIEEAKNELHKLL-----NEEELKG-----APLLILANKQDLPGALTESEL 121

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1811711706 206 QSKLEQEIAKVRQTRSKglldsGIGMDDGAGGDEEASWL 244
Cdd:cd00878   122 IELLGLESIKGRRWHIQ-----PCSAVTGDGLDEGLDWL 155
Arl4_Arl7 cd04152
Arf-like 4 (Arl4) and 7 (Arl7) GTPases; Arl4 (Arf-like 4) is highly expressed in testicular ...
 50-209 1.59e-06

Arf-like 4 (Arl4) and 7 (Arl7) GTPases; Arl4 (Arf-like 4) is highly expressed in testicular germ cells, and is found in the nucleus and nucleolus. In mice, Arl4 is developmentally expressed during embryogenesis, and a role in somite formation and central nervous system differentiation has been proposed. Arl7 has been identified as the only Arf/Arl protein to be induced by agonists of liver X-receptor and retinoid X-receptor and by cholesterol loading in human macrophages. Arl7 is proposed to play a role in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Older literature suggests that Arl6 is a part of the Arl4/Arl7 subfamily, but analyses based on more recent sequence data place Arl6 in its own subfamily.


Pssm-ID: 206719 [Multi-domain]  Cd Length: 183  Bit Score: 47.49  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  50 VLLVGPSGAGKTSLL-----TLFANGAPSATHTSQepqtavcqlpastkaredRYRCENDTTSRArpKFLLLDTPGHGKL 124
Cdd:cd04152     6 IVMLGLDSAGKTTVLyrlkfNEFVNTVPTKGFNTE------------------KIKVSLGNAKGV--TFHFWDVGGQEKL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 125 RdhgflPL--RGERALKGLVFMVDSAAVSSvtgLIEAAEYLHDVllllqkrhtqGKTSKTTSVPVLVAANKQDVFTSLPA 202
Cdd:cd04152    66 R-----PLwkSYTRCTDGIVFVVDSVDVER---MEEAKTELHKI----------TKFSENQGVPVLVLANKQDLPNALPV 127


                  ....*..
gi 1811711706 203 NLVQSKL 209
Cdd:cd04152   128 SEVEKLL 134
YeeP COG3596
Predicted GTPase [General function prediction only];
40-122 2.40e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 48.22  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  40 RKAVAQELPTVLLVGPSGAGKTSLL-TLFanGAPSATHTSQEPQTAVCQlpastkaredRYRCENDTTSRARpkflLLDT 118
Cdd:COG3596    32 RLLVELPPPVIALVGKTGAGKSSLInALF--GAEVAEVGVGRPCTREIQ----------RYRLESDGLPGLV----LLDT 95


                  ....
gi 1811711706 119 PGHG 122
Cdd:COG3596    96 PGLG 99
Arl9_Arfrp2_like cd04162
Arf-like 9 (Arl9)/Arfrp2-like GTPase; Arl9/Arfrp2-like subfamily. Arl9 (Arf-like 9) was first ...
 50-218 2.05e-05

Arf-like 9 (Arl9)/Arfrp2-like GTPase; Arl9/Arfrp2-like subfamily. Arl9 (Arf-like 9) was first identified as part of the Human Cancer Genome Project. It maps to chromosome 4q12 and is sometimes referred to as Arfrp2 (Arf-related protein 2). This is a novel subfamily identified in human cancers that is uncharacterized to date.


Pssm-ID: 133362 [Multi-domain]  Cd Length: 164  Bit Score: 43.98  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  50 VLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAVCqLPastkaredryrcendtTSRARPKFLLLDtpghgklrdhGF 129
Cdd:cd04162     2 ILVLGLDGAGKTSLLHSLSSERSLESVVPTTGFNSVA-IP----------------TQDAIMELLEIG----------GS 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 130 LPLRG--ERALKG---LVFMVDSAAVSSvtgLIEAAEYLHDvllLLQKrhtqgktskTTSVPVLVAANKQDVFTSLPANL 204
Cdd:cd04162    55 QNLRKywKRYLSGsqgLIFVVDSADSER---LPLARQELHQ---LLQH---------PPDLPLVVLANKQDLPAARSVQE 119

                         170
                  ....*....|....*
gi 1811711706 205 VQSKLE-QEIAKVRQ 218
Cdd:cd04162   120 IHKELElEPIARGRR 134
Arl3 cd04155
Arf-like 3 (Arl3) GTPase; Arl3 (Arf-like 3) is an Arf family protein that differs from most ...
 141-210 3.73e-05

Arf-like 3 (Arl3) GTPase; Arl3 (Arf-like 3) is an Arf family protein that differs from most Arf family members in the N-terminal extension. In is inactive, GDP-bound form, the N-terminal extension forms an elongated loop that is hydrophobically anchored into the membrane surface; however, it has been proposed that this region might form a helix in the GTP-bound form. The delta subunit of the rod-specific cyclic GMP phosphodiesterase type 6 (PDEdelta) is an Arl3 effector. Arl3 binds microtubules in a regulated manner to alter specific aspects of cytokinesis via interactions with retinitis pigmentosa 2 (RP2). It has been proposed that RP2 functions in concert with Arl3 to link the cell membrane and the cytoskeleton in photoreceptors as part of the cell signaling or vesicular transport machinery. In mice, the absence of Arl3 is associated with abnormal epithelial cell proliferation and cyst formation.


Pssm-ID: 206721 [Multi-domain]  Cd Length: 174  Bit Score: 43.54  E-value: 3.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 141 LVFMVDSaavSSVTGLIEAAEYLHDVLlllqkrhtqgKTSKTTSVPVLVAANKQDVFTSLPANLVQSKLE 210
Cdd:cd04155    86 LIYVIDS---ADRKRFEEAGQELVELL----------EEEKLAGVPVLVFANKQDLLTAAPAEEVAEALN 142
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 52-218 7.25e-05

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 42.23  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  52 LVGPSGAGKTSLLTLFANGAPSAT----HTSQEPQTAVCQLPASTkaredryrcendttsrarpKFLLLDTPGhgkLRDH 127
Cdd:cd00880     2 IFGRPNVGKSSLLNALLGQNVGIVspipGTTRDPVRKEWELLPLG-------------------PVVLIDTPG---LDEE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 128 G-FLPLRGERALK------GLVFMVDSaavssvTGLIEAAEYLHDVLLLLQKrhtqgktskttsvPVLVAANKQDvftsl 200
Cdd:cd00880    60 GgLGRERVEEARQvadradLVLLVVDS------DLTPVEEEAKLGLLRERGK-------------PVLLVLNKID----- 115

                         170
                  ....*....|....*...
gi 1811711706 201 panLVQSKLEQEIAKVRQ 218
Cdd:cd00880   116 ---LVPESEEEELLRERK 130
Arf pfam00025
ADP-ribosylation factor family; Pfam combines a number of different Prosite families together
 50-217 9.21e-05

ADP-ribosylation factor family; Pfam combines a number of different Prosite families together


Pssm-ID: 459636 [Multi-domain]  Cd Length: 160  Bit Score: 41.83  E-value: 9.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  50 VLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTavcqlpastkaredryrcenDTTSRARPKFLLLDTPGHGKLR---D 126
Cdd:pfam00025   3 ILILGLDNAGKTTILYKLKLGEIVTTIPTIGFNV--------------------ETVTYKNVKFTVWDVGGQESLRplwR 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 127 HGFlplrgeRALKGLVFMVDSAAVSSvtgLIEAAEYLHdvlLLLQKRHTQGktskttsVPVLVAANKQDVFTSLPANLVQ 206
Cdd:pfam00025  63 NYF------PNTDAVIFVVDSADRDR---IEEAKEELH---ALLNEEELAD-------APLLILANKQDLPGAMSEAEIR 123

                         170
                  ....*....|.
gi 1811711706 207 SKLEQEIAKVR 217
Cdd:pfam00025 124 ELLGLHELKDR 134
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 49-193 2.51e-04

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 39.91  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  49 TVLLVGPSGAGKTSLL-TLFANGAPsathTSQEPQTavcqlpasTKAREdRYRCENDttsraRPKFLLLDTPG--HGKLR 125
Cdd:pfam01926   1 RVALVGRPNVGKSTLInALTGAKAI----VSDYPGT--------TRDPN-EGRLELK-----GKQIILVDTPGliEGASE 62

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 126 DHGFLP--LRGERAlKGLVFMVDSAAvssvtGLIEAAEYLHDVLLLLQKrhtqgktskttsvPVLVAANK 193
Cdd:pfam01926  63 GEGLGRafLAIIEA-DLILFVVDSEE-----GITPLDEELLELLRENKK-------------PIILVLNK 113
ARLTS1 cd04156
Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11); ARLTS1 (Arf-like tumor suppressor gene 1), ...
 50-209 4.37e-04

Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11); ARLTS1 (Arf-like tumor suppressor gene 1), also known as Arl11, is a member of the Arf family of small GTPases that is believed to play a major role in apoptotic signaling. ARLTS1 is widely expressed and functions as a tumor suppressor gene in several human cancers. ARLTS1 is a low-penetrance suppressor that accounts for a small percentage of familial melanoma or familial chronic lymphocytic leukemia (CLL). ARLTS1 inactivation seems to occur most frequently through biallelic down-regulation by hypermethylation of the promoter. In breast cancer, ARLTS1 alterations were typically a combination of a hypomorphic polymorphism plus loss of heterozygosity. In a case of thyroid adenoma, ARLTS1 alterations were polymorphism plus promoter hypermethylation. The nonsense polymorphism Trp149Stop occurs with significantly greater frequency in familial cancer cases than in sporadic cancer cases, and the Cys148Arg polymorphism is associated with an increase in high-risk familial breast cancer.


Pssm-ID: 133356 [Multi-domain]  Cd Length: 160  Bit Score: 40.09  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  50 VLLVGPSGAGKTSLLTLFANGAPSATHTSQEPQTAVCQLPASTKaredryrcendttsrarpkFLLLDTPGHGKLRDHGF 129
Cdd:cd04156     2 VLLLGLDSAGKSTLLYKLKHAELVTTIPTVGFNVEMLQLEKHLS-------------------LTVWDVGGQEKMRTVWK 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706 130 LPLRGeraLKGLVFMVDSaavSSVTGLIEAAEYLHDVLlllQKRHTQGktskttsVPVLVAANKQDVFTSLPANLVQSKL 209
Cdd:cd04156    63 CYLEN---TDGLVYVVDS---SDEARLDESQKELKHIL---KNEHIKG-------VPVVLLANKQDLPGALTAEEITRRF 126
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 49-143 2.02e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706   49 TVLLVGPSGAGKTSLLTLFANGAPSA----------THTSQEPQTAVCQLPASTKAREDRYRCENDTTSRAR---PKFLL 115
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPgggviyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARklkPDVLI 83

                           90       100
                   ....*....|....*....|....*...
gi 1811711706  116 LDTPGHGKLRDHGFLPLRGERALKGLVF 143
Cdd:smart00382  84 LDEITSLLDAEQEALLLLLEELRLLLLL 111
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 38-69 3.93e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 37.48  E-value: 3.93e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1811711706  38 LYRKAVAQELPTVLLVGPSGAGKTSLLTLFAN 69
Cdd:pfam13191  15 ALDRVRSGRPPSVLLTGEAGTGKTTLLRELLR 46
FtsE COG2884
Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];
50-66 7.82e-03

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442130 [Multi-domain]  Cd Length: 223  Bit Score: 36.95  E-value: 7.82e-03
                          10
                  ....*....|....*..
gi 1811711706  50 VLLVGPSGAGKTSLLTL 66
Cdd:COG2884    31 VFLTGPSGAGKSTLLKL 47
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 34-117 7.95e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 36.36  E-value: 7.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811711706  34 IHTYLYRKAVAQELPTVLLVGPSGAGKTSLLTLFANgapsathTSQEPQTAVCQLPASTKAREDRYRCENDTT------- 106
Cdd:cd00009     6 AIEALREALELPPPKNLLLYGPPGTGKTTLARAIAN-------ELFRPGAPFLYLNASDLLEGLVVAELFGHFlvrllfe 78

                          90
                  ....*....|...
gi 1811711706 107 --SRARPKFLLLD 117
Cdd:cd00009    79 laEKAKPGVLFID 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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