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Conserved domains on  [gi|18079268|ref|NP_525041|]
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mitochondrial ribosomal protein L16, isoform A [Drosophila melanogaster]

Protein Classification

ribosomal protein L16( domain architecture ID 11089150)

ribosomal protein L16 binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
61-191 5.60e-46

Ribosomal protein L16p/L10e;


:

Pssm-ID: 459733  Cd Length: 132  Bit Score: 149.50  E-value: 5.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268    61 IRPPKMQKRL-RYMRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFATWRVPAPWQPITKKGQGQ 139
Cdd:pfam00252   1 PKRTKYRKSRkRYIRGVPTKGTTLDFGDYGLVALEGGQITARQLEAARIAINRYLKKTRGGKLWIRVFPDKPVTKKPGED 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18079268   140 RMGGGKGAIDHYVTPIKAGRVIVEIAGKCEFVEVKQFLQQVANQLPFQATVV 191
Cdd:pfam00252  81 RMGKGKGKPEGWVARVKPGRILFEIKGGVHEEVAKEALRLAAHKLPGKTKIV 132
 
Name Accession Description Interval E-value
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
61-191 5.60e-46

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 149.50  E-value: 5.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268    61 IRPPKMQKRL-RYMRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFATWRVPAPWQPITKKGQGQ 139
Cdd:pfam00252   1 PKRTKYRKSRkRYIRGVPTKGTTLDFGDYGLVALEGGQITARQLEAARIAINRYLKKTRGGKLWIRVFPDKPVTKKPGED 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18079268   140 RMGGGKGAIDHYVTPIKAGRVIVEIAGKCEFVEVKQFLQQVANQLPFQATVV 191
Cdd:pfam00252  81 RMGKGKGKPEGWVARVKPGRILFEIKGGVHEEVAKEALRLAAHKLPGKTKIV 132
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
 81-191 5.51e-35

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 120.67  E-value: 5.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268  81 NTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMnVNTMFATWRVPAPWQPITKKGQGQRMGGGKGAIDHYVTPIKAGRV 160
Cdd:cd01433   3 NKLFFGEYGLVALEPGRITAEQLEAARIAINRYL-KKKGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPGQI 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 18079268 161 IVEIAGKCEFVEVKQFLQQVANQLPFQATVV 191
Cdd:cd01433  82 LFEVRGVPEEEVAKEALRRAAKKLPIKTKIV 112
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 66-194 1.41e-14

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 68.14  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268  66 MQKRLRY-------MRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNtmFATW-RVpAPWQPITKKGQ 137
Cdd:COG0197   3 MPKRVKYrkqqrgrIKGVAKRGNKFAFGNYGLKALEPGQITSRQIEAARIAITRYLKRG--GKVWiRI-FPDKPLTKKPA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18079268 138 GQRMGGGKGAIDHYVTPIKAGRVIVEIAGkCEFVEVKQFLQQVANQLPFQATVVSQE 194
Cdd:COG0197  80 ETRMGAGKGKPEGWVAVVKPGRILFEIAG-VSEEVAKEALRLAAHKLPIKTRIVVRE 135
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
 66-166 2.02e-12

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 62.39  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268    66 MQKRLRY-------MRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFatWRVPAPWQPITKKGQG 138
Cdd:TIGR01164   1 SPKRTKYrkqqrgrVKGKAKRGNTVAFGEYGLQALEPGWITARQIEAARVAMTRYVKRGGKL--WIRIFPDKPYTKKPLE 78

                          90       100
                  ....*....|....*....|....*...
gi 18079268   139 QRMGGGKGAIDHYVTPIKAGRVIVEIAG 166
Cdd:TIGR01164  79 TRMGKGKGNPEYWVAVVKPGKILFEIAG 106
rpl16 CHL00044
ribosomal protein L16
 128-166 4.03e-06

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 44.89  E-value: 4.03e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 18079268  128 PWQPITKKGQGQRMGGGKGAIDHYVTPIKAGRVIVEIAG 166
Cdd:CHL00044  70 PDKPVTMRPAETRMGSGKGSPEYWVAVVKPGRILYEMGG 108
 
Name Accession Description Interval E-value
Ribosomal_L16 pfam00252
Ribosomal protein L16p/L10e;
61-191 5.60e-46

Ribosomal protein L16p/L10e;


Pssm-ID: 459733  Cd Length: 132  Bit Score: 149.50  E-value: 5.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268    61 IRPPKMQKRL-RYMRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFATWRVPAPWQPITKKGQGQ 139
Cdd:pfam00252   1 PKRTKYRKSRkRYIRGVPTKGTTLDFGDYGLVALEGGQITARQLEAARIAINRYLKKTRGGKLWIRVFPDKPVTKKPGED 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18079268   140 RMGGGKGAIDHYVTPIKAGRVIVEIAGKCEFVEVKQFLQQVANQLPFQATVV 191
Cdd:pfam00252  81 RMGKGKGKPEGWVARVKPGRILFEIKGGVHEEVAKEALRLAAHKLPGKTKIV 132
Ribosomal_L16_L10e cd01433
Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, ...
 81-191 5.51e-35

Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. Mutations in L16 and the adjoining bases of 23S rRNA confer antibiotic resistance in bacteria, suggesting a role for L16 in the formation of the antibiotic binding site. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16. L10e is the archaeal and eukaryotic cytosolic homolog of bacterial L16. L16 and L10e exhibit structural differences at the N-terminus.


Pssm-ID: 238714  Cd Length: 112  Bit Score: 120.67  E-value: 5.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268  81 NTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMnVNTMFATWRVPAPWQPITKKGQGQRMGGGKGAIDHYVTPIKAGRV 160
Cdd:cd01433   3 NKLFFGEYGLVALEPGRITAEQLEAARIAINRYL-KKKGGKLWIRVFPDHPVTKKPLETRMGKGKGKPEGWVARVKPGQI 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 18079268 161 IVEIAGKCEFVEVKQFLQQVANQLPFQATVV 191
Cdd:cd01433  82 LFEVRGVPEEEVAKEALRRAAKKLPIKTKIV 112
RplP COG0197
Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 66-194 1.41e-14

Ribosomal protein L16/L10AE [Translation, ribosomal structure and biogenesis]; Ribosomal protein L16/L10AE is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439967  Cd Length: 136  Bit Score: 68.14  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268  66 MQKRLRY-------MRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNtmFATW-RVpAPWQPITKKGQ 137
Cdd:COG0197   3 MPKRVKYrkqqrgrIKGVAKRGNKFAFGNYGLKALEPGQITSRQIEAARIAITRYLKRG--GKVWiRI-FPDKPLTKKPA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18079268 138 GQRMGGGKGAIDHYVTPIKAGRVIVEIAGkCEFVEVKQFLQQVANQLPFQATVVSQE 194
Cdd:COG0197  80 ETRMGAGKGKPEGWVAVVKPGRILFEIAG-VSEEVAKEALRLAAHKLPIKTRIVVRE 135
rplP_bact TIGR01164
ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ...
 66-166 2.02e-12

ribosomal protein L16, bacterial/organelle; This model describes bacterial and organellar ribosomal protein L16. The homologous protein of the eukaryotic cytosol is designated L10 [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273476  Cd Length: 125  Bit Score: 62.39  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18079268    66 MQKRLRY-------MRGPEMVHNTLLHKQYAIVATGGGRLRWGHYEMMRLTIGRKMNVNTMFatWRVPAPWQPITKKGQG 138
Cdd:TIGR01164   1 SPKRTKYrkqqrgrVKGKAKRGNTVAFGEYGLQALEPGWITARQIEAARVAMTRYVKRGGKL--WIRIFPDKPYTKKPLE 78

                          90       100
                  ....*....|....*....|....*...
gi 18079268   139 QRMGGGKGAIDHYVTPIKAGRVIVEIAG 166
Cdd:TIGR01164  79 TRMGKGKGNPEYWVAVVKPGKILFEIAG 106
rpl16 CHL00044
ribosomal protein L16
 128-166 4.03e-06

ribosomal protein L16


Pssm-ID: 176985  Cd Length: 135  Bit Score: 44.89  E-value: 4.03e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 18079268  128 PWQPITKKGQGQRMGGGKGAIDHYVTPIKAGRVIVEIAG 166
Cdd:CHL00044  70 PDKPVTMRPAETRMGSGKGSPEYWVAVVKPGRILYEMGG 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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