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Conserved domains on  [gi|1807825385|dbj|BBP19325|]
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repressor TnpA [Escherichia coli]

Protein Classification

IS1-like element transposase( domain architecture ID 1750064)

IS1-like element transposase acting on a specific type of insertion sequences (IS), the simplest class of procaryotic transposable elements which are capable of integrating into numerous sites within genomes via a transposition pathway independent of homologous re combination.

Gene Ontology:  GO:0006313

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS1 super family cl41321
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 8-91 2.34e-37

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


The actual alignment was detected with superfamily member NF033558:

Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 123.92  E-value: 2.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNS 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79


                  ....
gi 1807825385  88 GRSR 91
Cdd:NF033558   80 GPRQ 83
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 8-91 2.34e-37

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 123.92  E-value: 2.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNS 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79


                  ....
gi 1807825385  88 GRSR 91
Cdd:NF033558   80 GPRQ 83
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
1-90 1.13e-24

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 92.62  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   1 MASVSISCPSCSATDgVVRNGKSTAGHQRYLCSHCRKTWQLQFTY--TASQPGTHQKIIDMAMNGVGCRATARIMGVGLN 78
Cdd:COG3677    12 RWPNGPVCPHCGSTR-IVKNGKTRNGRQRYRCKDCGRTFTVTTGTifEGSKLPLWLQAIRLLLNGISLRQIARVLGVSYK 90

                          90
                  ....*....|..
gi 1807825385  79 TILRHLKNSGRS 90
Cdd:COG3677    91 TVWRWLHRIREA 102
HTH_Tnp_IS1 pfam12759
InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This ...
 43-88 2.93e-24

InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.


Pssm-ID: 289525 [Multi-domain]  Cd Length: 46  Bit Score: 86.14  E-value: 2.93e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1807825385 43 FTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSG 88
Cdd:pfam12759  1 YTYEARKPGTKEKIIEMAMNGAGCRATARTLKVGINTVIRTLKNSR 46
transpos_ISL3 NF033550
ISL3 family transposase;
7-91 1.87e-04

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 38.34  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   7 SCPSC-SATDGVVRNGKSTAGH--------------QRYLCSHCRKTWQLQFT-------YTAsqpGTHQKIIDMAMNGV 64
Cdd:NF033550   12 TCPECgKPSRRVHDTGKRRIRHlpifgrpvylelrvRRFKCPECGKTFTEELPwarkrsrITL---RLEAAVLALLLELM 88

                          90       100
                  ....*....|....*....|....*..
gi 1807825385  65 GCRATARIMGVGLNTILRHLKNSGRSR 91
Cdd:NF033550   89 SVAAVARQLGVSWSTVWRILLRAVRRL 115
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 8-91 2.34e-37

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 123.92  E-value: 2.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNS 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79


                  ....
gi 1807825385  88 GRSR 91
Cdd:NF033558   80 GPRQ 83
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
1-90 1.13e-24

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 92.62  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   1 MASVSISCPSCSATDgVVRNGKSTAGHQRYLCSHCRKTWQLQFTY--TASQPGTHQKIIDMAMNGVGCRATARIMGVGLN 78
Cdd:COG3677    12 RWPNGPVCPHCGSTR-IVKNGKTRNGRQRYRCKDCGRTFTVTTGTifEGSKLPLWLQAIRLLLNGISLRQIARVLGVSYK 90

                          90
                  ....*....|..
gi 1807825385  79 TILRHLKNSGRS 90
Cdd:COG3677    91 TVWRWLHRIREA 102
HTH_Tnp_IS1 pfam12759
InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This ...
 43-88 2.93e-24

InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.


Pssm-ID: 289525 [Multi-domain]  Cd Length: 46  Bit Score: 86.14  E-value: 2.93e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1807825385 43 FTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSG 88
Cdd:pfam12759  1 YTYEARKPGTKEKIIEMAMNGAGCRATARTLKVGINTVIRTLKNSR 46
Zn_Tnp_IS1 pfam03811
InsA N-terminal domain; This appears to be a short zinc binding domain found in IS1 InsA ...
 1-36 6.38e-11

InsA N-terminal domain; This appears to be a short zinc binding domain found in IS1 InsA family protein. It is found at the N-terminus of the protein and may be a DNA-binding domain.


Pssm-ID: 281762 [Multi-domain]  Cd Length: 35  Bit Score: 52.21  E-value: 6.38e-11
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 1807825385  1 MASVSISCPSCSATDgVVRNGKSTAGHQRYLCSHCR 36
Cdd:pfam03811  1 MASVSIHCPRCSSTD-VYRHGKSTAGHQRFRCRHCR 35
transpos_ISL3 NF033550
ISL3 family transposase;
7-91 1.87e-04

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 38.34  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807825385   7 SCPSC-SATDGVVRNGKSTAGH--------------QRYLCSHCRKTWQLQFT-------YTAsqpGTHQKIIDMAMNGV 64
Cdd:NF033550   12 TCPECgKPSRRVHDTGKRRIRHlpifgrpvylelrvRRFKCPECGKTFTEELPwarkrsrITL---RLEAAVLALLLELM 88

                          90       100
                  ....*....|....*....|....*..
gi 1807825385  65 GCRATARIMGVGLNTILRHLKNSGRSR 91
Cdd:NF033550   89 SVAAVARQLGVSWSTVWRILLRAVRRL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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