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Conserved domains on  [gi|1807799438|ref|NP_001365292|]
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DNA helicase MCM9 isoform 4 [Homo sapiens]

Protein Classification

minichromosome maintenance protein MCM( domain architecture ID 1000350)

minichromosome maintenance protein MCM is one of the highly conserved MCM complex proteins, the complex may have helicase activity and is essential for the initiation of DNA replication

Gene Ontology:  GO:0005524|GO:0004386|GO:0003682

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
34-318 2.09e-58

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 199.26  E-value: 2.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  34 ITGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIkadfEQYYT-FCRPSSCPSlesC 112
Cdd:COG1241    87 ITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV----PQTGEkLQEPHECPG---C 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 113 ----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRW 182
Cdd:COG1241   157 grqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 183 KPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVILASLCPQVFGMYLVKLAVAMVL 262
Cdd:COG1241   224 RTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKIIASIAPSIYGYEEIKEAIALQL 298
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1807799438 263 AGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:COG1241   299 FGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
34-318 2.09e-58

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 199.26  E-value: 2.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  34 ITGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIkadfEQYYT-FCRPSSCPSlesC 112
Cdd:COG1241    87 ITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV----PQTGEkLQEPHECPG---C 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 113 ----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRW 182
Cdd:COG1241   157 grqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 183 KPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVILASLCPQVFGMYLVKLAVAMVL 262
Cdd:COG1241   224 RTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKIIASIAPSIYGYEEIKEAIALQL 298
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1807799438 263 AGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:COG1241   299 FGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM smart00350
minichromosome maintenance proteins;
50-318 9.25e-58

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 194.02  E-value: 9.25e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438   50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 128
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 203
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  204 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 279
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1807799438  280 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
239-319 9.64e-50

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 167.72  E-value: 9.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 239 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:cd17760     1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                  .
gi 1807799438 319 I 319
Cdd:cd17760    81 L 81
MCM pfam00493
MCM P-loop domain;
238-321 3.03e-29

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 111.47  E-value: 3.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 238 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 317
Cdd:pfam00493  16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                  ....
gi 1807799438 318 GIVC 321
Cdd:pfam00493  96 GLTA 99
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
74-319 2.03e-17

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 83.12  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  74 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 150
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 151 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 214
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 215 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 285
Cdd:PTZ00111  425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1807799438 286 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:PTZ00111  499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
34-318 2.09e-58

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 199.26  E-value: 2.09e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  34 ITGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIkadfEQYYT-FCRPSSCPSlesC 112
Cdd:COG1241    87 ITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV----PQTGEkLQEPHECPG---C 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 113 ----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRW 182
Cdd:COG1241   157 grqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRIEQ 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 183 KPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVILASLCPQVFGMYLVKLAVAMVL 262
Cdd:COG1241   224 RTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKIIASIAPSIYGYEEIKEAIALQL 298
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1807799438 263 AGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:COG1241   299 FGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM smart00350
minichromosome maintenance proteins;
50-318 9.25e-58

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 194.02  E-value: 9.25e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438   50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 128
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 203
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  204 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 279
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1807799438  280 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
239-319 9.64e-50

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 167.72  E-value: 9.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 239 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:cd17760     1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                  .
gi 1807799438 319 I 319
Cdd:cd17760    81 L 81
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
240-320 2.41e-30

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 116.67  E-value: 2.41e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17706     2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                  .
gi 1807799438 320 V 320
Cdd:cd17706    82 T 82
MCM pfam00493
MCM P-loop domain;
238-321 3.03e-29

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 111.47  E-value: 3.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 238 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 317
Cdd:pfam00493  16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                  ....
gi 1807799438 318 GIVC 321
Cdd:pfam00493  96 GLTA 99
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
240-319 3.82e-25

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 102.53  E-value: 3.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17761     3 IISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
50-177 9.31e-25

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 96.78  E-value: 9.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  50 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSSSPT 128
Cdd:pfam17207   6 RSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVHEKS 72
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1807799438 129 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 177
Cdd:pfam17207  73 KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
240-319 1.46e-22

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 95.51  E-value: 1.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17757     2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
240-319 1.79e-22

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 95.59  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17753     2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
242-319 3.36e-19

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 86.31  E-value: 3.36e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1807799438 242 ASLCPQVFGMYLVKLAVAMVLAGGIQRTdATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17758     4 ASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
239-319 4.34e-19

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 85.90  E-value: 4.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 239 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 318
Cdd:cd17756     1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                  .
gi 1807799438 319 I 319
Cdd:cd17756    81 L 81
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
240-319 5.78e-19

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 85.57  E-value: 5.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAT-GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 317
Cdd:cd17755     1 RLArSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                  ..
gi 1807799438 318 GI 319
Cdd:cd17755    81 GL 82
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
74-319 2.03e-17

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 83.12  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438  74 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 150
Cdd:PTZ00111  279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 151 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 214
Cdd:PTZ00111  346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 215 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 285
Cdd:PTZ00111  425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1807799438 286 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:PTZ00111  499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
240-319 4.24e-17

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 79.88  E-value: 4.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799438 240 ILASLCPQVFGMYLVKLAVAMVLAGGIQRT--DATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 317
Cdd:cd17759     2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYadDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                  ..
gi 1807799438 318 GI 319
Cdd:cd17759    82 GL 83
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
243-319 4.83e-17

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 79.82  E-value: 4.83e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1807799438 243 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 319
Cdd:cd17754     5 SLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
281-309 1.27e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1807799438 281 HLLLVGDPGTGKSQFLK-YAAKITPRSVLT 309
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErLAAALSNRPVFY 30
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
279-300 4.07e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 39.02  E-value: 4.07e-03
                          10        20
                  ....*....|....*....|..
gi 1807799438 279 ESHLLLVGDPGTGKSQFLKYAA 300
Cdd:COG5635   180 KKRLLILGEPGSGKTTLLRYLA 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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