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Conserved domains on  [gi|18077894|ref|NP_542241|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Tachyglossus aculeatus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-164 8.74e-64

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 193.48  E-value: 8.74e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLN---LAIMVGMLGVVWYEFFEEVDLGVGYD------LLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWIL 151
Cdd:MTH00109  82 TWVSNKVVLGallLGLLMELLLVLYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 18077894  152 FLTIFVVLEVTRG 164
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-164 8.74e-64

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 193.48  E-value: 8.74e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLN---LAIMVGMLGVVWYEFFEEVDLGVGYD------LLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWIL 151
Cdd:MTH00109  82 TWVSNKVVLGallLGLLMELLLVLYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 18077894  152 FLTIFVVLEVTRG 164
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-160 1.34e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.97  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    17 MAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAM-ATEEYPETWVDYTVVLNLAIMV 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18077894    96 GMLGVVWYEF-FEEVDLGVGYDLLDLGGMEVLGgdfngvSLLYACGGWELVFSGWILFLTIFVVLE 160
Cdd:pfam00499  81 LLLALLLLVLlSASLTPAAAAAAPDVGNIEAIG------ELLFTDYLLPFELASVLLLVALVGAIV 140
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 4-67 6.95e-03

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 35.09  E-value: 6.95e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18077894   4 FIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVF 67
Cdd:COG0839   4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLF 67
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-164 8.74e-64

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 193.48  E-value: 8.74e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLN---LAIMVGMLGVVWYEFFEEVDLGVGYD------LLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWIL 151
Cdd:MTH00109  82 TWVSNKVVLGallLGLLMELLLVLYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 18077894  152 FLTIFVVLEVTRG 164
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-164 1.62e-47

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 152.22  E-value: 1.62e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLNLAI---MVGMLGVVWYEFFEEVDLGVGYdllDLGGMEVLGGDFNGVSLLYACGGWELVFSGWILFLTIFV 157
Cdd:MTH00138  81 SWGSWSVLGYVVGylvGVVLAAGLFWGGWYEGSWVVVD---ELKEFSVLRGDVGGVALMYSSGGGMLVICAWVLLLTLFV 157


                 ....*..
gi 18077894  158 VLEVTRG 164
Cdd:MTH00138 158 VLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-164 1.24e-42

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 139.60  E-value: 1.24e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLNLAIMVGMLgVVWYEFFEEVDLGVGYDLLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWILFLTIFVVLE 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLLLL-IVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLE 159


                 ....
gi 18077894  161 VTRG 164
Cdd:MTH00065 160 VTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-164 5.83e-37

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 125.25  E-value: 5.83e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVV---LNLAIMVGMLGVVWYEFFEEVDLGVGYdlLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWILFLTIFV 157
Cdd:MTH00115  81 AWGDWGVVgyvVGFVLVVVVVGVVVGGLWGMEGVGVVT--VDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFV 158


                 ....*..
gi 18077894  158 VLEVTRG 164
Cdd:MTH00115 159 VLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-164 3.07e-22

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 87.35  E-value: 3.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    1 MMYFIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   81 TWVDYTVVLNlaIMVGMLGVVWYEFFEevdLGVGYDLLDLGGMEVLGGDFNGVSLLYACGGWELVFSGWILFLTIFVVLE 160
Cdd:MTH00214  81 SWGGWSVLLF--FLFYLLGLGFVGFYF---YGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVLFLVLFVVLE 155


                 ....
gi 18077894  161 VTRG 164
Cdd:MTH00214 156 LVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 2-164 2.08e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 58.76  E-value: 2.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    2 MYFIYLLSVMLVLSFMAFASNpSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEYPet 81
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL-SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894   82 wvdYTVVLNLAIMVGMLGVVWYEFFEEVDLGVGYDLLDLGGMEVLggdfNGVSLLYACGGWELVFSGWILFLTIFVVLEV 161
Cdd:MTH00045  78 ---SVSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSLSDL----VGSSELYNSGGLYLLLGGFILLVALVVALVI 150


                 ...
gi 18077894  162 TRG 164
Cdd:MTH00045 151 SFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-160 1.34e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 55.97  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    17 MAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAM-ATEEYPETWVDYTVVLNLAIMV 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18077894    96 GMLGVVWYEF-FEEVDLGVGYDLLDLGGMEVLGgdfngvSLLYACGGWELVFSGWILFLTIFVVLE 160
Cdd:pfam00499  81 LLLALLLLVLlSASLTPAAAAAAPDVGNIEAIG------ELLFTDYLLPFELASVLLLVALVGAIV 140
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-78 1.34e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 43.07  E-value: 1.34e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18077894    2 MYFIYLLSVMLVLSFMaFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMATEEY 78
Cdd:MTH00212   1 MLLSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 5-74 1.40e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 40.26  E-value: 1.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18077894    5 IYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVFGYTAAMA 74
Cdd:MTH00152   3 LMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 4-67 6.95e-03

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 35.09  E-value: 6.95e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18077894   4 FIYLLSVMLVLSFMAFASNPSPIYGGLSLVLSGGVGCGIIVSLGGSFLGLIVFLVYLGGMLVVF 67
Cdd:COG0839   4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLF 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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