|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
96-491 |
2.12e-87 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 273.18 E-value: 2.12e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 96 VAGFMLAEALQTHNIDRRIALYLIGWMGRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLaevvgREIPDGEAS 175
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIA-----AALGSEKRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 176 NMRIATLLGTAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLTfWLYPPEVEDVS 255
Cdd:COG0471 76 KFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLY-RLLPPEIKEVP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 256 DAQAQASKYLEEEGALSRSGRRAAYIFAATAVLWMLGGLGFLFEGvlpgpvfvtlfggtgpsvfgleghrgilyfvVVGL 335
Cdd:COG0471 155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPIA-------------------------------VVAL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 336 LAIPALVLSGADDWENLID-IDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVFTVLVTELSS 414
Cdd:COG0471 204 LGAVLLLLTGVLTWKDAYKsIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFAS 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1806957307 415 NTATTTILAPVLISlgsvLAGTLGVDPvhaaVTLAITGAIAASFAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:COG0471 284 NTATAALLLPIAIS----LAQALGVNP----LPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLN 352
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
30-491 |
3.03e-77 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 249.57 E-value: 3.03e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 30 PTPARLDVAAQYALATMALAAILWVTNALPLSVTALL-IPVALTVFGIYDTM--EPALSGFADPLIYLFVAGFMLAEALQ 106
Cdd:TIGR00785 1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVLSAFkfKNALSGFADPTIWLFFGAFILATALV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 107 THNIDRRIALYLIGWMGRSPRLLILAIMV-ATAFLSMWVSNTA-TTAMMTPVALGVLaeVVGREIPDGEASNMRIATLLG 184
Cdd:TIGR00785 81 KTGLGKRIAYKLVGKMGGTTLGLGYFLVFlETLLAPMWPSNTArAGGILLPIIKSLL--PLLGSKPEKSPRKIGKYLMLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 185 TAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLtFWLYPPEVEDVSDAQAQASKY 264
Cdd:TIGR00785 159 IAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLL-YVLFPPELKLKDEVDLWAKEE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 265 LEEEGALSRSGRRAAYIFAATAVLWMLGGlgflFEGVlpgpvfvtlfggtgpsvfgleghrgilYFVVVGLLAIPALVLS 344
Cdd:TIGR00785 238 LEEMGPMSFREKALLGIFLLALLLWIFGG----SLGI---------------------------NASVVALLAVVLMLFL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 345 GADDWENLI--DIDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVV-NAPLALVVLAVIVFTVLVTELSSNTATTTI 421
Cdd:TIGR00785 287 GIVTWKDIQknKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDgLSPTIAVLVLVVLFYIILYFFASNTAHTAA 366
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 422 LAPVLISLGSVlagtLGVDPVHAAVTLAITGAIAasfAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:TIGR00785 367 LVPIFFSVASA----QGIPLELLALALALSASLM---GFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIG 429
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
43-491 |
1.56e-66 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 219.38 E-value: 1.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 43 LATMALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEpALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGWM 122
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE-AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 123 GRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAevvgreipdgEASNMRIATLLGTAYAASVGGVGTLIGTPP 202
Cdd:cd01115 80 GKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAA----------KLDISPSRLLMPLAFAASIGGMLTLIGTPP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 203 NVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLTFWlyppevedvsdaqaqaskyleeegalsrsgrraayIF 282
Cdd:cd01115 150 NLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA-----------------------------------VL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 283 AATAVLWMlgglgFLFEGVLPGPVFVTLFGGtgpsvfgleghrgilyfvvvgllAIPALVLSGADDWENLIDIDWGTIVL 362
Cdd:cd01115 195 IITIVLLA-----ALAAITGLLPVSVAIAIG-----------------------AIVLVFGGVLLTKEDYKSIDWGIIFL 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 363 FGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISlgsvLAGTLGVDPv 442
Cdd:cd01115 247 FAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALS----IALSLGLPP- 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1806957307 443 haaVTLAITGAIAASFAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:cd01115 322 ---EALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLS 367
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
14-491 |
2.93e-56 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 194.90 E-value: 2.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 14 ASIVLALVVTGAIAAAPTPARLDVAAQYALATMALAAILWVTNALPLSVTALLIPVALTVFGIYDT---MEPALSGFADP 90
Cdd:pfam00939 5 WKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLakaLSWALSGFSST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 91 LIYLFVAGFMLAEALQTHNIDRRIALYLIGWMGRSPrlLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEVVGREIP 170
Cdd:pfam00939 85 TTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAFGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 171 DGEASNMRIAT---LLGTAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLtFWLY 247
Cdd:pfam00939 163 DPEKGSERRIGaylMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLAPLLL-YVLY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 248 PPEVEDVSDAQAQASKYLEEEGALSRSGRRAAYIFAATAVLWMLGGlgflfegvlpgpvfvtlfggtgpsvfGLEGHRGI 327
Cdd:pfam00939 242 PPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG--------------------------SLNIDATT 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 328 LYFVVVGLLAIPALVlsgadDWENLID--IDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVF 405
Cdd:pfam00939 296 VAIIGLALMLLLRIL-----DWKDIVKnkGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 406 TVLV-TELSSNTATTTILAPVLISLGSVLAgtlGVDPVHAAVTLAITGAIaasFAFALPVATPPNAIVFGSGHLDQRDMI 484
Cdd:pfam00939 371 FYLShYLFASATAHTAAMLPIFAAVAQAIP---GAPPLLAALLLGFAISL---GGFLTPYGTGPGPIYFGSGYLKVKDWW 444
|
....*..
gi 1806957307 485 RAGIVLN 491
Cdd:pfam00939 445 RIGAILT 451
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
96-491 |
2.12e-87 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 273.18 E-value: 2.12e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 96 VAGFMLAEALQTHNIDRRIALYLIGWMGRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLaevvgREIPDGEAS 175
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIA-----AALGSEKRS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 176 NMRIATLLGTAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLTfWLYPPEVEDVS 255
Cdd:COG0471 76 KFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLY-RLLPPEIKEVP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 256 DAQAQASKYLEEEGALSRSGRRAAYIFAATAVLWMLGGLGFLFEGvlpgpvfvtlfggtgpsvfgleghrgilyfvVVGL 335
Cdd:COG0471 155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPIA-------------------------------VVAL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 336 LAIPALVLSGADDWENLID-IDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVFTVLVTELSS 414
Cdd:COG0471 204 LGAVLLLLTGVLTWKDAYKsIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFAS 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1806957307 415 NTATTTILAPVLISlgsvLAGTLGVDPvhaaVTLAITGAIAASFAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:COG0471 284 NTATAALLLPIAIS----LAQALGVNP----LPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLN 352
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
30-491 |
3.03e-77 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 249.57 E-value: 3.03e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 30 PTPARLDVAAQYALATMALAAILWVTNALPLSVTALL-IPVALTVFGIYDTM--EPALSGFADPLIYLFVAGFMLAEALQ 106
Cdd:TIGR00785 1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLaIPIIAVLLGVLSAFkfKNALSGFADPTIWLFFGAFILATALV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 107 THNIDRRIALYLIGWMGRSPRLLILAIMV-ATAFLSMWVSNTA-TTAMMTPVALGVLaeVVGREIPDGEASNMRIATLLG 184
Cdd:TIGR00785 81 KTGLGKRIAYKLVGKMGGTTLGLGYFLVFlETLLAPMWPSNTArAGGILLPIIKSLL--PLLGSKPEKSPRKIGKYLMLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 185 TAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLtFWLYPPEVEDVSDAQAQASKY 264
Cdd:TIGR00785 159 IAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLL-YVLFPPELKLKDEVDLWAKEE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 265 LEEEGALSRSGRRAAYIFAATAVLWMLGGlgflFEGVlpgpvfvtlfggtgpsvfgleghrgilYFVVVGLLAIPALVLS 344
Cdd:TIGR00785 238 LEEMGPMSFREKALLGIFLLALLLWIFGG----SLGI---------------------------NASVVALLAVVLMLFL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 345 GADDWENLI--DIDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVV-NAPLALVVLAVIVFTVLVTELSSNTATTTI 421
Cdd:TIGR00785 287 GIVTWKDIQknKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDgLSPTIAVLVLVVLFYIILYFFASNTAHTAA 366
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 422 LAPVLISLGSVlagtLGVDPVHAAVTLAITGAIAasfAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:TIGR00785 367 LVPIFFSVASA----QGIPLELLALALALSASLM---GFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIG 429
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
43-491 |
1.56e-66 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 219.38 E-value: 1.56e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 43 LATMALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEpALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGWM 122
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKE-AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 123 GRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAevvgreipdgEASNMRIATLLGTAYAASVGGVGTLIGTPP 202
Cdd:cd01115 80 GKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAA----------KLDISPSRLLMPLAFAASIGGMLTLIGTPP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 203 NVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLTFWlyppevedvsdaqaqaskyleeegalsrsgrraayIF 282
Cdd:cd01115 150 NLVASGYLESLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLA-----------------------------------VL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 283 AATAVLWMlgglgFLFEGVLPGPVFVTLFGGtgpsvfgleghrgilyfvvvgllAIPALVLSGADDWENLIDIDWGTIVL 362
Cdd:cd01115 195 IITIVLLA-----ALAAITGLLPVSVAIAIG-----------------------AIVLVFGGVLLTKEDYKSIDWGIIFL 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 363 FGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISlgsvLAGTLGVDPv 442
Cdd:cd01115 247 FAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALS----IALSLGLPP- 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1806957307 443 haaVTLAITGAIAASFAFALPVATPPNAIVFGSGHLDQRDMIRAGIVLN 491
Cdd:cd01115 322 ---EALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLS 367
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
14-491 |
2.93e-56 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 194.90 E-value: 2.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 14 ASIVLALVVTGAIAAAPTPARLDVAAQYALATMALAAILWVTNALPLSVTALLIPVALTVFGIYDT---MEPALSGFADP 90
Cdd:pfam00939 5 WKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLLakaLSWALSGFSST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 91 LIYLFVAGFMLAEALQTHNIDRRIALYLIGWMGRSPrlLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEVVGREIP 170
Cdd:pfam00939 85 TTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPAFGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 171 DGEASNMRIAT---LLGTAYAASVGGVGTLIGTPPNVVAVAFLDRLAGVEISFAQWLVVGLPIVVLTLPLTWYVLtFWLY 247
Cdd:pfam00939 163 DPEKGSERRIGaylMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPGVILLLLAPLLL-YVLY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 248 PPEVEDVSDAQAQASKYLEEEGALSRSGRRAAYIFAATAVLWMLGGlgflfegvlpgpvfvtlfggtgpsvfGLEGHRGI 327
Cdd:pfam00939 242 PPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG--------------------------SLNIDATT 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 328 LYFVVVGLLAIPALVlsgadDWENLID--IDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLAVIVF 405
Cdd:pfam00939 296 VAIIGLALMLLLRIL-----DWKDIVKnkGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 406 TVLV-TELSSNTATTTILAPVLISLGSVLAgtlGVDPVHAAVTLAITGAIaasFAFALPVATPPNAIVFGSGHLDQRDMI 484
Cdd:pfam00939 371 FYLShYLFASATAHTAAMLPIFAAVAQAIP---GAPPLLAALLLGFAISL---GGFLTPYGTGPGPIYFGSGYLKVKDWW 444
|
....*..
gi 1806957307 485 RAGIVLN 491
Cdd:pfam00939 445 RIGAILT 451
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
50-490 |
1.58e-39 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 147.78 E-value: 1.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 50 AILWVTNALPLSVTALLIPVALTVFGIYdTMEPALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIgWMGRSPRLL 129
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLA-RASKGSRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 130 ILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEVVGreipdgeasNMRIATLLGTAYAASVGGVGTLIGTPPNVVAVAF 209
Cdd:cd00625 79 LLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGL---------SPPVPLLLALAFAANIGGAATPIGNPPNLIIASL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 210 ldrlagVEISFAQWLVVGLPIVVLtLPLTWYVLTFWLYPPEVEDVSDAQAQASKYLEEEgalsRSGRRAAYIFAATAVLW 289
Cdd:cd00625 150 ------SGLGFLDFLAFMAPPALG-LLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPA----RPLLKKFLLLALLLLLL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 290 MLGGLGFLFEGVLPgpvfvtlfggtgpsvfgleghrgilyfVVVGLLAIPALVLSGADDWENLIDIDWGTIVLFGGGLSL 369
Cdd:cd00625 219 FVLLFFFLIPLGLI---------------------------ALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 370 ADALAETDATQWLARSVfDAVVNAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISLGSVLAGTLGvdpVHAAVTLA 449
Cdd:cd00625 272 VGALESTGLLEWLAELL-VALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPEPAWLA---LALGSTLG 347
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1806957307 450 ITGAIAASFAFALPVATPPNAIVfgsgHLDQRDMIRAGIVL 490
Cdd:cd00625 348 GNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPL 384
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
50-436 |
1.39e-31 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 124.35 E-value: 1.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 50 AILWVTNALPLSVTALLIPVALTVFGIYdTMEPALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGWMGRSPRLL 129
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVL-TPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 130 ILAIMVATAFLSMWVSNTATTAMMTPVALGVLAevvgreipdgEASNMRIATLLGTAYAASVGGVGTLIGTPPNVVAVAF 209
Cdd:pfam03600 80 LVALMLATALLSAFLSNDGTVLIMIPIVLALAR----------RLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 210 LDrLAGVEISFAQWLVVGLPIVVLTLPLTWYVLTFWLYPPEVEDVSdaqaqaskyLEEEGALSRSGRRAAYIFAATAVLW 289
Cdd:pfam03600 150 LG-LSFGDFGFFMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAE---------LEELRKRAIKDKLLLAISALVLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 290 MLgglgflfegvlpgpvfvtlfggtgpsvfgleghrGILYFVVVGLLAIPALVLSGADDWENLID-IDWGTIVLFGGGLS 368
Cdd:pfam03600 220 IL----------------------------------GFLLLSVLALAGALLLLLTGVLDPEEALKaVDWSTLLFFAGLFI 265
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1806957307 369 LADALAETDATQWLARSVFDAVvnaPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISLGSVLAGT 436
Cdd:pfam03600 266 LVGALEKTGLADALADALGGLS---GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLG 330
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
47-431 |
3.90e-17 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 83.25 E-value: 3.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 47 ALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEpALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGWMGRSP 126
Cdd:COG1055 12 TYLLIILEPRGLNRAVAALLGAALLLLLGVVSLED-ALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 127 RLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEvvgREIPdgeasnmRIATLLGTAYAASVGGVGTLIGTPPN-VV 205
Cdd:COG1055 91 RRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARR---LGLN-------PVPFLIAIVFAANIGGAATPIGNPTNiMI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 206 AVAFldrlagvEISFAQWLVVGLPIVVLTLPLTWYVLtFWLYPPEVEDVSDAQAQaskylEEEGALSRSGRRAAYIFAAT 285
Cdd:COG1055 161 ASAG-------GLSFLDFLANLFPPSLVSLLVTLLVL-YLLFRKELPAAPDLEDD-----PKEAIKDRRLLRISLLVLAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 286 AVlwmlggLGFLFEGVLPGPVFVTLFGGtgpsvfgleghrgilyfvvvgllAIPALVLSGADDWENLIDIDWGTIVLFGG 365
Cdd:COG1055 228 LL------VGFVLHSFLGLPPALIALLG-----------------------AAVLLLLARVDVREVLKKVDWSTLLFFIG 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1806957307 366 GLSLADALAETDATQWLARsVFDAVVNAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISLGS 431
Cdd:COG1055 279 LFVVVGGLENTGLLDLLAE-LLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGA 343
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
42-246 |
4.21e-12 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 67.49 E-value: 4.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 42 ALATMALAAILWVTNA---LPLSVTALLIPVALTVFGIYDtMEPALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYL 118
Cdd:COG0471 177 ALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLT-WKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADAL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 119 IGWM-GRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVlaevvgreipdGEASNMRIATLLGTAYAASVGGVGTL 197
Cdd:COG0471 256 LPLLgGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISL-----------AQALGVNPLPLALAVAFAASCAFLLP 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1806957307 198 IGTPPNVVAVAfldrlAGVeISFAQWLVVGLPIVVLTLPLTWYVLTFWL 246
Cdd:COG0471 325 VGTPPNAIVYG-----SGY-YKFKDFLKVGLPLNLIGLVVLLLLGPLWW 367
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
21-235 |
1.33e-11 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 66.12 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 21 VVTGAIAAAPTPARLDVAAQYALATMALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEPALSGFADPLIYLFVAGFM 100
Cdd:cd00625 191 KLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFV 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 101 LAEALQTHNIDRRIALYLIGWMGRSPRLLILAIMVATAFLSMWVSNTATTAMMTPVALgvlaevvgreipdgEASNMRIA 180
Cdd:cd00625 271 LVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAA--------------SLAPPEPA 336
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1806957307 181 TLLGtAYAASVGGVGTLIGTPPNVVAVAFLDRlAGVEISFAQWLVVGLPIVVLTL 235
Cdd:cd00625 337 WLAL-ALGSTLGGNLTLIGSLANLIPLGAAEN-AGVGISFGEFLKVGLPLTLLSL 389
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
48-437 |
4.03e-11 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 64.61 E-value: 4.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 48 LAAILWVTNALPLSVTALLIPVALTVFGIYdTMEPALSGFADPLIyLFVAGFMLAEALQTHNIDRRIALYLIGWMGRSPR 127
Cdd:cd01117 1 LALGRVPGLRLDRWAIALLGAALMLLFGVI-SLEDAPAAIDLDTI-ILLFGLMVVSAALELSGFFDALGSRILVKAGSPR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 128 LLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEvvgREIPDgeasnmrIATLLGTAYAASVGGVGTLIGTPPNVVAV 207
Cdd:cd01117 79 RLLFLLVLLSGILSALLTNDTACLVFTPIVLELARV---AGLPP-------IPLLLALATAANIGSAATPIGNPQNLLIA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 208 AFLdrlagvEISFAQWLVVGLPIVVLTLpLTWYVLTFWLYPPEVEDVSDAQAQASKYLEEEGALSRsgrraayifaatAV 287
Cdd:cd01117 149 SES------GISFPFFLAAMAPLALLGL-LLLLILLLVLFPGELKGLPLDKATKEEGVGARKLAVK------------LL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 288 LWMLGGLGFLFEGVLPGPVFVTLFggtgpsvfgleghrgilyfvvvglLAIPALVLSGADDWENLIDIDWGTIVLFGGGL 367
Cdd:cd01117 210 VLILLLLVAFLALLGVIPLWTAAL------------------------VAAVLLLLTRLKPRRVLKKVDWGLLLFFAGLF 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 368 SLADALAETDATQWLARSvfdavvnAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLIS----------LGSVLAGTL 437
Cdd:cd01117 266 ILVGGFAQGLPLEGLSRL-------LPLLDSVLSLFLVSIGLSQLISNVPAVLLLLPFLPSadekdwlllaAGSTIAGNL 338
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
43-247 |
6.55e-11 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 64.38 E-value: 6.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 43 LATMALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEpaLSGFADPLIYLFVAG-FMLAEALQTHNIDRRIALYLIGW 121
Cdd:COG1055 225 LALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVRE--VLKKVDWSTLLFFIGlFVVVGGLENTGLLDLLAELLASL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 122 MGRSPRLLILAIMVATAFLSMWVSNTATTAMMTPValgvlaevvgreIPDGEASNMRIATLLGTAYAASVGGVGTLIGTP 201
Cdd:COG1055 303 TGGNLLLAALLILWLSAILSAVVDNVPLVAALLPL------------IPDLGATGNPEPLWLALALGATLGGNLTPIGSA 370
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1806957307 202 PNVVAVAFLDRlAGVEISFAQWLVVGLPIVVLTLPLTWYVLTFWLY 247
Cdd:COG1055 371 ANVIVLGIAEK-KGIKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
46-235 |
1.28e-08 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 56.88 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 46 MALAAILWVtnalPLSVTALLIPVALTVFGIYDTMEPALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGWMGRS 125
Cdd:cd01116 231 FVLHSPLGV----SLGWIALLGALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGR 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 126 PRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEVvgreipDGEASNMRIATLLGtayaASVGGVGTLIGTPPNVV 205
Cdd:cd01116 307 IAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQL------GIPLLPLWWALALG----ACLGGNGTLIGASANVV 376
|
170 180 190
....*....|....*....|....*....|
gi 1806957307 206 AVAFLDRlAGVEISFAQWLVVGLPIVVLTL 235
Cdd:cd01116 377 AAGIAEQ-HGYKISFWEFLKVGFPIMLVSL 405
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
126-433 |
2.96e-08 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 55.72 E-value: 2.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 126 PRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLAEVVGREIPdgeasnmriaTLLGTAYAASVGGVGTLIGTPPNVV 205
Cdd:cd01116 84 PWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVP----------VLISEVIAANIGGAATLIGDPPNIM 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 206 avafLDRLAGVeiSFAQWLVVGLPIVVLTLPLTwYVLTFWLYppevEDVSDAQAQASKYLEEEGALSRSGRRAAYIFAAT 285
Cdd:cd01116 154 ----IGSAAGL--TFNDFLLHMLPSVVLALVVT-FILLYFLY----RNILKAREEDVLALAELEPKYPIKDKVLLLKSLT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 286 AVLWMLggLGFLFEGVLP-GPVFVTLFGgtgpsvfgleghrgilyfvvvgllAIPALVLSGADDWENLI-DIDWGTIVLF 363
Cdd:cd01116 223 ILTLVI--IGFVLHSPLGvSLGWIALLG------------------------ALLLLLLADKLDFEDVLsRVEWDTLLFF 276
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 364 GGGLSLADALAETDATQWLARSVfDAVVNAPLALVVLAVIVFTVLVTELSSNTATTTILAPVLISLGSVL 433
Cdd:cd01116 277 AGLFVLVGGLEELGIIEWIAELL-VGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQL 345
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
42-245 |
6.28e-07 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 51.43 E-value: 6.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 42 ALATMALAAILWVTNALPLSVTALLIPVALTVFGIYDTMEpALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGW 121
Cdd:cd01115 195 IITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKE-DYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 122 MGRSPRLLILA-IMVATAFLSMWVSNTATTAMMTPVALGVLAEVVGREIPdgeasnmriaTLLGTAYAASVgGVGTLIGT 200
Cdd:cd01115 274 LGGLPPFAILLlLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEA----------LLLAVAIGASC-AFMLPVGT 342
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1806957307 201 PPNVVAVAFLDrlagveISFAQWLVVGLPI-VVLTLPLTWYVLTFW 245
Cdd:cd01115 343 PPNAIVLGPGG------YKFSDFAKVGLPLsILSLVVSVTMIPLIW 382
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
42-162 |
1.65e-05 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 46.92 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 42 ALATMALAAILWVTNALPLSVtALLIPVALTVFGIYDTMEPALSGFADPLIYLFVAGFMLAEALQTHNIDRRIALYLIGW 121
Cdd:pfam03600 208 LLAISALVLALVILGFLLLSV-LALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1806957307 122 MGrsPRLLILAIMVATAFLSMWVSNTATTAMMTPVALGVLA 162
Cdd:pfam03600 287 SG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAP 325
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
332-472 |
3.25e-04 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 43.07 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 332 VVGLLAIPALVLSGADDWENLID-IDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVlAVIVFTVLVT 410
Cdd:pfam03600 13 VVALLGAVLLVLLGVLTPEEALSgIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLV-ALMLATALLS 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1806957307 411 ELSSNTATTTILAPVLISLgsvlAGTLGVDPVHAAVTLAITGAIAASfafALPVATPPNAIV 472
Cdd:pfam03600 92 AFLSNDGTVLIMIPIVLAL----ARRLGLPPSPLLIALAFAANIGGT---ATPIGDPPNIII 146
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
324-485 |
1.39e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 41.08 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 324 HRGILYFVVVGLLAIPALVLSGADDWENLIDIDWGTIVLFGGGLSLADALAETDATQWLARSVFDAVVNAPLALVVLaVI 403
Cdd:cd01116 14 HRTVAALAGALWLVILGLATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLL-LG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806957307 404 VFTVLVTELSSNTATTTILAPVLIslgsVLAGTLGVDPVHAAVTLAITGAIAASfafALPVATPPNAIVFGSGHLDQRDM 483
Cdd:cd01116 93 LLTAFLSAFLDNVTTVLLMVPVTI----RLCEVLGLNPVPVLISEVIAANIGGA---ATLIGDPPNIMIGSAAGLTFNDF 165
|
..
gi 1806957307 484 IR 485
Cdd:cd01116 166 LL 167
|
|
| |
