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Conserved domains on  [gi|1806241095|dbj|BBX31018|]
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MFS transporter [Mycolicibacterium mageritense]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-398 1.03e-48

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17329:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 169.72  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd17329     2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  96 LVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGD-RRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAA 174
Cdd:cd17329    82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 175 VFAVLTVAQLLALPRHATEPAAQRG-SVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQsWVVAG 253
Cdd:cd17329   162 LFLLAALVLLFLLPETRPKRRAAEKtEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE-SLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 254 LFVVSGLVAVAGQLRITRWFaARWGAGRSLVIGMLLLAVAFVPVAVVPdsgrlGVVALLATAALLALGSAAVFPFEMDTV 333
Cdd:cd17329   241 LLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAVLAFAN-----TLAVLILAMIVLTLGEMLVFPAVQTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1806241095 334 VSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAAravdRPELVWLGLLAVGVVSALALWVL 398
Cdd:cd17329   315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALLLGL 375
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 16-398 1.03e-48

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 169.72  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd17329     2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  96 LVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGD-RRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAA 174
Cdd:cd17329    82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 175 VFAVLTVAQLLALPRHATEPAAQRG-SVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQsWVVAG 253
Cdd:cd17329   162 LFLLAALVLLFLLPETRPKRRAAEKtEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE-SLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 254 LFVVSGLVAVAGQLRITRWFaARWGAGRSLVIGMLLLAVAFVPVAVVPdsgrlGVVALLATAALLALGSAAVFPFEMDTV 333
Cdd:cd17329   241 LLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAVLAFAN-----TLAVLILAMIVLTLGEMLVFPAVQTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1806241095 334 VSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAAravdRPELVWLGLLAVGVVSALALWVL 398
Cdd:cd17329   315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALLLGL 375
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
4-410 3.06e-26

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 108.99  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095   4 LVAQFRSfdLPSRLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIV 83
Cdd:PRK11646    3 RVSQARN--LGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  84 AGCLLRTAGFGLLVFADSlPVMLIASAA-TGFAGALFNPAVRAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALI 161
Cdd:PRK11646   81 TGMLMRAAGFATMAIAHE-PWLLWLSCIlSGLGGTLFDPPRTALVIKLIRPHqRGRFFSLLMMQDSAGAVIGALLGSWLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 162 ALDFRVTAAVAAAVFAVLTVAQLLALPrhATEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAY 241
Cdd:PRK11646  160 QYDFRLVCATGAVLFVLAAAFNAWLLP--AYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVND 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 242 LA--PGAQSWVVAGLFVVSGLVAVAgqlrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVALLATAALLA 319
Cdd:PRK11646  238 IAgsPSAVKWMYAIEACLSLTLLYP----IARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSII 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 320 LGsaavfPFEMDTVVSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAARAVDRPELVWLGLLAVGVVSALALWVLH 399
Cdd:PRK11646  314 AE-----PARETLSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQF 388

                         410
                  ....*....|.
gi 1806241095 400 RRGHLRPRILT 410
Cdd:PRK11646  389 SQKRIARRMLE 399
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-290 3.71e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.08  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  13 LPSRLLMVNQFGINLGFYMLMPYLAgFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAG 92
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  93 FGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAA 170
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 171 VAAAVFAVLTVAQLLALPRhatEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLApGAQSWV 250
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE---SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1806241095 251 VAGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLL 290
Cdd:COG2814   245 AGLLLALFGLGGVLGAL-LAGRLADRFGRRRLLLIGLLLL 283
MFS_1 pfam07690
Major Facilitator Superfamily;
18-360 1.57e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.13  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  18 LMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLV 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  98 FADSLPVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALIA-LDFRVTAAVAAAV 175
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 176 FAVLTVAQLLALPRHATEPAAQRG----SVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYlapGAQSWVV 251
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEearlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL---GLSALLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 252 AGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVValLATAALLALGSAAVFPFEMD 331
Cdd:pfam07690 238 GLLLGLGGLLGAIGRL-LLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL--LLALLLLGFGFGLVFPALNA 314

                         330       340
                  ....*....|....*....|....*....
gi 1806241095 332 TVVSLSGDRLVATHYGFYNTIVGVGILLG 360
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 16-398 1.03e-48

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 169.72  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd17329     2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  96 LVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGD-RRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAA 174
Cdd:cd17329    82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPeNRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 175 VFAVLTVAQLLALPRHATEPAAQRG-SVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQsWVVAG 253
Cdd:cd17329   162 LFLLAALVLLFLLPETRPKRRAAEKtEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE-SLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 254 LFVVSGLVAVAGQLRITRWFaARWGAGRSLVIGMLLLAVAFVPVAVVPdsgrlGVVALLATAALLALGSAAVFPFEMDTV 333
Cdd:cd17329   241 LLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAVLAFAN-----TLAVLILAMIVLTLGEMLVFPAVQTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1806241095 334 VSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAAravdRPELVWLGLLAVGVVSALALWVL 398
Cdd:cd17329   315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALLLGL 375
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
4-410 3.06e-26

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 108.99  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095   4 LVAQFRSfdLPSRLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIV 83
Cdd:PRK11646    3 RVSQARN--LGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  84 AGCLLRTAGFGLLVFADSlPVMLIASAA-TGFAGALFNPAVRAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALI 161
Cdd:PRK11646   81 TGMLMRAAGFATMAIAHE-PWLLWLSCIlSGLGGTLFDPPRTALVIKLIRPHqRGRFFSLLMMQDSAGAVIGALLGSWLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 162 ALDFRVTAAVAAAVFAVLTVAQLLALPrhATEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAY 241
Cdd:PRK11646  160 QYDFRLVCATGAVLFVLAAAFNAWLLP--AYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVND 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 242 LA--PGAQSWVVAGLFVVSGLVAVAgqlrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVALLATAALLA 319
Cdd:PRK11646  238 IAgsPSAVKWMYAIEACLSLTLLYP----IARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSII 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 320 LGsaavfPFEMDTVVSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAARAVDRPELVWLGLLAVGVVSALALWVLH 399
Cdd:PRK11646  314 AE-----PARETLSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQF 388

                         410
                  ....*....|.
gi 1806241095 400 RRGHLRPRILT 410
Cdd:PRK11646  389 SQKRIARRMLE 399
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 23-371 2.13e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 77.23  E-value: 2.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  23 FGINLGFYMLMPYLAGFLAGpLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSL 102
Cdd:cd17325     6 FLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 103 PVMLIASAATGFAGALFNPAVRAYLAADAGDRRV-EAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAAVAAAVFAVLT 180
Cdd:cd17325    85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERgRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALLAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 181 VAQLLALPRHATEPAAQRGSVLDD---WRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLApGAQSWVVAGLFVV 257
Cdd:cd17325   165 VLALLLLPEPRPPPNKRAVSAARLrsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 258 SGLVAVAGQLrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPdsgrlGVVALLATAALLALGSAAVFPFEMDTVVSLS 337
Cdd:cd17325   244 QGLASALSQP-PAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1806241095 338 GDRLVATHYGFYNTIVGVGILLGNLATGSAITAA 371
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-290 3.71e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 73.08  E-value: 3.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  13 LPSRLLMVNQFGINLGFYMLMPYLAgFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAG 92
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  93 FGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAA 170
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 171 VAAAVFAVLTVAQLLALPRhatEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLApGAQSWV 250
Cdd:COG2814   169 VNAVLALLALLLLLRLLPE---SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASA 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1806241095 251 VAGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLL 290
Cdd:COG2814   245 AGLLLALFGLGGVLGAL-LAGRLADRFGRRRLLLIGLLLL 283
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 17-163 1.06e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.84  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  17 LLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLL 96
Cdd:cd17325   203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1806241095  97 VFADSLPVMLIASAATGFAGALFNPAVRAYLAADAG-DRRVEAFATFNVFYQAGILLGPLVGMALIAL 163
Cdd:cd17325   283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
22-371 1.01e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.16  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  22 QFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLG-----YKPLIVAGCLLRTAGFGLL 96
Cdd:COG2211    19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  97 VFADSLP------VMLIASAATGFAGALFNPAVRAYLAA--DAGDRRVEAFATFNVFYQAGILLGPLVGMALI------- 161
Cdd:COG2211    99 FTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAEltPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVaafggda 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 162 ALDFRVTAAVAAAVFAVLTVAQLLALPRHATePAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAY 241
Cdd:COG2211   179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPV-PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 242 LApGAQSWVVAGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLLA-VAFVPVAVVPDSGRLGVVALLATAALLAL 320
Cdd:COG2211   258 VL-GLSAALVGLLLALYFLAALLGAP-LWPRLAKRFGKKKAFIIGLLLAAlGLLLLFFLGPGNLWLLLVLAALAGIGLGA 335

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1806241095 321 GSAAVFPFEMDTVVS---LSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAA 371
Cdd:COG2211   336 ILVLPWAMLADVVDYdewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_1 pfam07690
Major Facilitator Superfamily;
18-360 1.57e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.13  E-value: 1.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  18 LMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLV 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  98 FADSLPVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALIA-LDFRVTAAVAAAV 175
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 176 FAVLTVAQLLALPRHATEPAAQRG----SVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYlapGAQSWVV 251
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEearlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL---GLSALLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 252 AGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVValLATAALLALGSAAVFPFEMD 331
Cdd:pfam07690 238 GLLLGLGGLLGAIGRL-LLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL--LLALLLLGFGFGLVFPALNA 314

                         330       340
                  ....*....|....*....|....*....
gi 1806241095 332 TVVSLSGDRLVATHYGFYNTIVGVGILLG 360
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALG 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
23-401 1.69e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.29  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  23 FGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSL 102
Cdd:COG2223    14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 103 PVMLIASAATGF-AGALFNPAVRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAAVAAAVFAVLT 180
Cdd:COG2223    94 WLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 181 VAQLLALPRHATEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSY--VLSFQVYLALPLQAAYLAPGAQSWVVAGLFVVS 258
Cdd:COG2223   174 VLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFgsFIGFSSWLPPYLVDQFGLSAATAGLLAALFALL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 259 GLVAVAgqlrITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVALLATAALLALGSAAVFPFemdtVVSLSG 338
Cdd:COG2223   254 GALGRP----LGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL----VPDIFP 325

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1806241095 339 DRLVATHYGFYNTIVGVGILLGNLATGSAITAARAvdrPELVWLGLLAVGVVSALALWVLHRR 401
Cdd:COG2223   326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS---YTAAFLVFAVLALVALVLTLLLYRR 385
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 32-289 3.62e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 57.95  E-value: 3.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  32 LMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMfivgGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAA 111
Cdd:cd17478    18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLF----GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 112 TGFAGALFNPAVRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLL---ALP 188
Cdd:cd17478    94 AGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLrlrPLK 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 189 RHATEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALplqaaYLAPGAQSWVVAGLFVVSGLVAVAGQLR 268
Cdd:cd17478   174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPF-----YLVQRGYSLVFAGLLLSLFLFAGAIGTL 248

                         250       260
                  ....*....|....*....|.
gi 1806241095 269 ITRWFAARWGAGRSLVIGMLL 289
Cdd:cd17478   249 IGGPLSDRFGRRRVIIASLLL 269
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 18-290 1.96e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  18 LMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAvGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLV 97
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  98 FADSLPVMLIASAATGFAGALFNPAVRAYLAADAG-DRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAAVAAAV 175
Cdd:cd17489    80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 176 FAVLTVAQLL---ALPRHATEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFqvylaLPLQAAylapgAQSWVVA 252
Cdd:cd17489   160 ALLALLLVFLvkdPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTF-----LPLYAA-----ERGISNA 229

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1806241095 253 GLF-VVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLL 290
Cdd:cd17489   230 GLFfTVYAIALLLSRP-FSGKLSDRKGPKTVIIPGLLLL 267
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-162 3.46e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd17324   201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1806241095  96 LVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALIA 162
Cdd:cd17324   281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLD 347
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
44-165 4.13e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.86  E-value: 4.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  44 LGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAV 123
Cdd:COG0738    38 FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAA 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1806241095 124 RAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALIALDF 165
Cdd:COG0738   118 NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGL 159
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 40-290 7.42e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.11  E-value: 7.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  40 LAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALF 119
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 120 NPAVRAYLAA-DAGDRRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLLALPRHATEPAAQR 198
Cdd:cd17474   105 GPLALTLIGDlFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 199 GSVLDDWRSVVANRSFL-MFAAAMIGSYVL-SFQVYLALPLQAAYlapGAQSWVVAGLFVVSGLVAVAGQLRITRWFAAR 276
Cdd:cd17474   185 ATKLRDLKKALRGRGLLtFLVSAFLYFFLYfAFLTYLPFLLELLY---GISPIIIGLLFAGWSVLLALGSLFVGRLLKKR 261

                         250
                  ....*....|....
gi 1806241095 277 WGAGRSLVIGMLLL 290
Cdd:cd17474   262 FGARRILVIGLLLY 275
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 31-365 1.23e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  31 MLMPYLAGFLAGpLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLG-YKPLIVAGCLLRTAGFGLLVFADSLPVMLIAS 109
Cdd:cd17370    17 MARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 110 AATGFAGALFNPAVRAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALIAL---DFRVTAAVAAAVFAVLTVAQLL 185
Cdd:cd17370    96 ILERLGKGIRTPPRDALLADATPPSgRGKAFGLHRALDTLGAVLGPLLAALLLYLlggNYRTIFLLAAIPALLALLILLF 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 186 ALPRHATEPAAQRGSVLDDWRSVvaNRSFLMF--AAAMIGSYVLSFQvYLALPLQAAYLAPgaqsWVVAGLFVVSGLVAV 263
Cdd:cd17370   176 VVKEYPRPPKLRKKSKKTSLKKL--PKAFWLYllAVALFALGNFSFA-FLILRAQELGLSA----ALIPLLYALFNLVYA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 264 AGQLRITRWFaARWGAGRSLVIGMLLLAVAFVPVAVVPDSGrlGVVALLATAALLALGSAAVFPFemdTVVSLSGDRLVA 343
Cdd:cd17370   249 LAAYPAGRLS-DRIGRKKLLILGYLSLALAYLGFALGSSLW--LLLLGFILWGLYMGAQESIERA---AVADLVPAELRG 322

                         330       340
                  ....*....|....*....|..
gi 1806241095 344 THYGFYNTIVGVGILLGNLATG 365
Cdd:cd17370   323 TAYGLFNTVVGIGWLLASLIAG 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 44-396 4.95e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 4.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  44 LGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAV 123
Cdd:cd06174    26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAV 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 124 RAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLLALPRHATEPAAQR---- 198
Cdd:cd06174   106 LALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARakne 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 199 ----GSVLDDWRSVVANRSF--LMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQSWVVAGLFVVSGLVAVAgqlrITRW 272
Cdd:cd06174   186 eassKSVLKLLKRVLKNPGLwlLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSL----LLGL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 273 FAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVALLATAALLALGSAAVFPFEMDTVVSlsgdRLVATHYGFYNTI 352
Cdd:cd06174   262 LSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP----EIRGTAFGLLNTF 337

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1806241095 353 VGVGILLGNLATGSAITAAravDRPELVWLGLLAVGVVSALALW 396
Cdd:cd06174   338 GFLGGAIGPLLAGFLLAAT---FGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-401 2.65e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  23 FGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSL 102
Cdd:COG2271    19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 103 PVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAAVAAAVFAVLT 180
Cdd:COG2271    99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPGLLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 181 VAQLLALprhatepaaqrgsvlddwrsvvanrsFLMFAAAMIGSYVlsFQVYLALPLQAAYLAPGAQSWVVAGLFVVSGL 260
Cdd:COG2271   179 LLRFWLL--------------------------ALAYFLVYFALYG--FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 261 VAVAGQLRITRWFAARwgaGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVALLATAALLALGSAAVFPFemdtVVSLSGDR 340
Cdd:COG2271   231 VGSLLGGWLSDRLGRR---RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL----AAELFPKK 303

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1806241095 341 LVATHYGFYNTIVGVGILLGNLATGSAITAAravdRPELVWLGLLAVGVVSALALWVLHRR 401
Cdd:COG2271   304 ARGTASGLVNTFGFLGGALGPLLVGYLLDAT----GYQAAFLLLAALALLAALLALLLLRE 360
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 16-290 2.84e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.07  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGpLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd06173     2 RLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  96 LVFA-----DSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRVEAFATFN-VFYQAGILLGPLVGMALIALDFRVTA 169
Cdd:cd06173    81 LALLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNsLATQLARIIGPALGGLLVALLGPGGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 170 AVAAAVFAVLTVAQLLALPRHATEPAAQRGSVLDD-----WRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLqAAYLAP 244
Cdd:cd06173   161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPL-LAKEVL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1806241095 245 GAQSWVVAGLFVVSGLVAVAGQLrITRWFAARWGAGRSLVIGMLLL 290
Cdd:cd06173   240 GGGAAGYGLLLAAFGVGALLGAL-LLGRLSKRRRRGRLLLIGALLL 284
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 27-160 2.98e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  27 LGFYMLMPYLAGFL--AGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPV 104
Cdd:cd17330    10 LGFGIVFPVLPFYVreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1806241095 105 MLIASAATGFAGALFnPAVRAYLA-ADAGDRRVEAFATFNVFYQAGILLGPLVGMAL 160
Cdd:cd17330    90 LFLARFLDGLTGGNV-SVAQAYIAdITDEEERAKAFGIISAAFGLGFILGPALGGFL 145
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-163 5.17e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  14 PSRLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGF 93
Cdd:COG2211   229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  94 GLLVFA--DSLPVMLIASAATGFAGALFNPAVRAYLA--ADAGD----RRVEA--FATFNVFYQAGILLGPLVGMALIAL 163
Cdd:COG2211   309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLAdvVDYDEwktgRRREGlyFGIFTFAIKLGQALAGALAGLLLAL 388
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 33-290 5.42e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 44.87  E-value: 5.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  33 MPYLAGFLAGPLGLAAWAVGLVLGVRNFSQqgmfIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAAT 112
Cdd:cd17320    22 LPAIARDLGASASAVQLTLSAYLLGFALGQ----LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 113 GFAGALFNPAVRAYLA-ADAGDRRVEAFATFNVFYQAGILLGPLVGMALIA-LDFRVTAAVAAAVFAVLTVAQLLALPRH 190
Cdd:cd17320    98 GLGAAAGSVVARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLfFGWRAIFVFLALLGLLLLLLVLLFLPET 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 191 ATEPAAQR--GSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALP---LQAAYLAPGAQSWVVAGLFVVSGLVAvag 265
Cdd:cd17320   178 LPEEKRKPllSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPfiyIEQLGLSPAQFGLLFALNAIALILGS--- 254

                         250       260
                  ....*....|....*....|....*
gi 1806241095 266 qlRITRWFAARWGAGRSLVIGMLLL 290
Cdd:cd17320   255 --LLNGRLVRRFGPRRLLRLGLLLL 277
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
36-290 6.81e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  36 LAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFA 115
Cdd:COG2807    40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 116 GALFNPAVRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALI-ALDFRVTAAVAAAVFAVLTVAQLLALPRH--AT 192
Cdd:COG2807   120 IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRRpaAA 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 193 EPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLsfQVYLALPLQAAYLAPGAQSWVVAglfvVSGLVAVAGQLrITRW 272
Cdd:COG2807   200 AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAV--VAWLPPILRDAGLSAATAGLLLS----LFQLAGIPGSL-LVPL 272

                         250
                  ....*....|....*...
gi 1806241095 273 FAARWGAGRSLVIGMLLL 290
Cdd:COG2807   273 LADRLGDRRPLLLLLGLL 290
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 26-156 9.06e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 44.13  E-value: 9.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  26 NLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVM 105
Cdd:cd17472     9 MLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGL 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1806241095 106 LIASAATGfAGALfnPAVRAYLAADAGD--RRVEAFA----TFNVFYQAGILLGPLV 156
Cdd:cd17472    89 ILGRALQG-SGAI--SSVVMALLADLTReeNRTKAMAligaSIGIAFAISMVLGPLL 142
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 17-290 1.04e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.08  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  17 LLMVNQFGINLGFYMLMPyLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLL 96
Cdd:cd17324     3 ALALAAFAIGTTEYVIQG-LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  97 VFADSLPVMLIASAATGFAGALFNPAVRAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGmALIA--LDFRVTAAVAA 173
Cdd:cd17324    82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLG-GLLGqlLGWRAAFLAIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 174 AVFAVLTVAQLLALPRHATEPAAQRGSVLdDWRSVVANRS--FLMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQswvV 251
Cdd:cd17324   161 VLALLAALLLWRLLPSLPPKKPGSLGLLS-SLLLLLRNPRlrLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA---I 236

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1806241095 252 AGLFVVSGLVAVAGQLRITRWfAARWGAGRSLVIGMLLL 290
Cdd:cd17324   237 IGLLLLFGVAGVVGSPLAGRL-ADRGGRRALLIALLLLA 274
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 64-163 1.35e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  64 GMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAAD-AGDRRVEAFATF 142
Cdd:cd17321    46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATfPGERRGRALGLW 125

                          90       100
                  ....*....|....*....|.
gi 1806241095 143 NVFYQAGILLGPLVGMALIAL 163
Cdd:cd17321   126 GAVVGIGAALGPLLGGLLLEL 146
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 44-290 2.58e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.49  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  44 LGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAV 123
Cdd:COG0477    44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 124 RAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLLALPRHATEPAAQRGSVL 202
Cdd:COG0477   124 LALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 203 DDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAYLAPGAQSWVVAGLFVVSGLVAVAGQLRITRWFAARWGAGRS 282
Cdd:COG0477   204 AALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283


                  ....*...
gi 1806241095 283 LVIGMLLL 290
Cdd:COG0477   284 LLLLLLLL 291
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 32-289 3.01e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 42.62  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  32 LMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAA 111
Cdd:cd17388    21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRII 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 112 TGFAGALFnpAVRAYLAAD--AGDRRVEAFATFNVFYQAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLLALPR 189
Cdd:cd17388   101 AGITGATG--AVAAAYIADvtPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 190 haTEPAAQRGSVLDDWRSVVANRSFLMFAAAMIGSYVLSFQVYLALPLQAAylapgaqSWVVAGLFV------------- 256
Cdd:cd17388   179 --SLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPAT-------TWVLFTEDRfdwsptmvglsla 249

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1806241095 257 VSGLVAVAGQLRITRWFAARWGAGRSLVIGMLL 289
Cdd:cd17388   250 VFGLLHALFQAFVTGPIAKRLGEKRAILLGLAA 282
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 30-360 4.57e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.21  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  30 YMLMPYLAGFLAGpLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLG-YKPLIVAGCLLRTAGFGLLVFADSLPVMLIA 108
Cdd:cd17490    13 YVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 109 SAATGFAGALFNPAVRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGmALIALDFRVTAAVAAAVFAVLTVAQLLALP 188
Cdd:cd17490    92 RFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIG-GLIAEHFGMRAPFLLAALAGVLGFILSLFI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 189 RHATEPAAQRGSVLDDWRSVVANRSFLMFAA-AMIGSYVLSFQVYLALPLQAAYLapGAQSWVVAGLFVVSGLVAVAGQL 267
Cdd:cd17490   171 KEERREKKPVLTELKELLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLIAKQL--GASSFQLGLLSIIYLLPNALASL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 268 RITRWFAARWGAGRSLVIGMLLLAVAFVPVAVVPDSGRLGVVallatAALLALGSAAVFPFEMDTVVSLSGDRLVATHYG 347
Cdd:cd17490   249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLL-----QALNGFGTGILFPLLMSLSIEGVPAEQRSTAMG 323

                         330
                  ....*....|...
gi 1806241095 348 FYNTIVGVGILLG 360
Cdd:cd17490   324 FFQAIYALGMFLG 336
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 23-163 5.00e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  23 FGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSL 102
Cdd:cd17473   207 FLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGL 286

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1806241095 103 PVMLIASAATGFAGALFNPAVRAYLAADAG-DRRVEAFATFNVFYQAGILLGPLVGMALIAL 163
Cdd:cd17473   287 WVVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
17-166 5.02e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  17 LLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLG--YKPLIVAGCLLRTAGFG 94
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1806241095  95 LLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRV-EAFATFNVFYQ-AGILLGPLVGMALIALDFR 166
Cdd:COG2271   264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARgTASGLVNTFGFlGGALGPLLVGYLLDATGYQ 337
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 18-288 1.72e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  18 LMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLG-YKPLIVAGCLLRTAGFGLL 96
Cdd:cd17471     1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  97 VFADSLPVMLIASAATGFAGALFNPA----VRAYLAADAGDRRVEAFATFNVFYQAGILLGPLVGMALIA-LDFRVTAAV 171
Cdd:cd17471    81 AFLRNYWVLLLVGVVLLSLGAAAFPQlfalAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDvLGFTGLFLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 172 AAAVFAVLTVAQLLALP-----RHATEPAAQRGSVLDDWRSVVANRSFLMFAAAMiGSYVLSFQVYLALPLQAAYLAPGA 246
Cdd:cd17471   161 AALLYLVVALLVLFLLPsvkppAQKATPASSLVKAPVNRRLLLLFAAFTLLFAAN-SMYIIAMPLYVTNELGGSESWVGL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1806241095 247 QSWVVAGLFVVSGLVAVagqlritrWFAARWGAGRSLVIGML 288
Cdd:cd17471   240 LFGLAAALEIPIMLLAG--------LLAKRFGKRRLLLAGFL 273
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 16-160 2.79e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQ-GMFIVGGTLADRLGYKPLIVAGCLLRTAGFG 94
Cdd:cd17474   201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1806241095  95 LLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAG-DRRVEAFATFNVFYQAGILLGPLVGMAL 160
Cdd:cd17474   281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEERGTASSLYNFVRFLGQAVGPLLFGLL 347
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 44-160 3.34e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  44 LGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAV 123
Cdd:cd17370   229 LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIE 308

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1806241095 124 RAYLAADA-GDRRVEAFATFNVFYQAGILLGPLVGMAL 160
Cdd:cd17370   309 RAAVADLVpAELRGTAYGLFNTVVGIGWLLASLIAGYL 346
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 16-162 4.10e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIVAGCLLRTAGFGL 95
Cdd:cd06173   211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1806241095  96 LVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALIA 162
Cdd:cd06173   291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLAD 358
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 70-398 4.77e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  70 GTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRVEAFAT---FNVFY 146
Cdd:cd17355    59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALgilTAGGG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 147 QAGILLGPLVGMALIALDFRVTAAVAAAVFAVLTVAQLLALPRHATEPAAQRGSVLDD------WRSVVANRSF--LMFA 218
Cdd:cd17355   139 LGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPaspgstLKEALRSASFwlLALA 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 219 AAMIGSYVLSFQVYLALPLQAAYLAPGAQSWVVAGLfvvsGLVAVAGQLrITRWFAARWGAGRSLVIGMLLLAVAFVPVA 298
Cdd:cd17355   219 FFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALI----GLFNIVGRL-LSGWLGDRYSPRRLLAASYALRALGLALLL 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095 299 VVPDSGrlgvVALLATAALLALGSAAVFPFEMDTVVSLSGDRLVATHYGFYNTIVGVGILLGNLATGSAITAARAVDrpe 378
Cdd:cd17355   294 LLPFPP----LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYT--- 366

                         330       340
                  ....*....|....*....|
gi 1806241095 379 LVWLGLLAVGVVSALALWVL 398
Cdd:cd17355   367 AAWALAVALGLIAALLVLPI 386
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 70-164 6.10e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.36  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  70 GTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATG-FAGALfnPAVRAYLA-ADAGDRRVEAFATFNVFYQ 147
Cdd:cd17390    52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGiFKHTQ--SLCKAYLSdLVSEQERSRVLGRFNAASS 129

                          90
                  ....*....|....*..
gi 1806241095 148 AGILLGPLVGMALIALD 164
Cdd:cd17390   130 LGFILGPVVGGHLAETD 146
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 67-162 8.95e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.07  E-value: 8.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  67 IVGGTLADRLGYKPLIVAGCLLRTAGFGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRVEAFATFNVFY 146
Cdd:cd17333    49 LLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFF 128

                          90
                  ....*....|....*.
gi 1806241095 147 QAGILLGPLVGMALIA 162
Cdd:cd17333   129 GLGALIGPLIATSLLT 144
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-165 9.00e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.18  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  16 RLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGY-KPLIVAGCLLRTAGFG 94
Cdd:cd06174   206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrKPLLLIGLLLMALGLA 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1806241095  95 LLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDR-RVEAFATFNVFYQAGILLGPLVGMALIALDF 165
Cdd:cd06174   286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 14-157 9.94e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 37.94  E-value: 9.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095  14 PSRLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFI-VGGTLADRLGYKPLIVAGCLLRTAG 92
Cdd:cd17330   175 PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAIIG 254

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1806241095  93 FGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLAADAGDRRVEAFATFNVFYQA-GILLGPLVG 157
Cdd:cd17330   255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSlARIIGPLLA 320
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 4-128 1.00e-02

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 37.89  E-value: 1.00e-02
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1806241095   4 LVAQFRSFDLPSRLLMVNQFGINLGFYMLMPYLAGFLAGPLGLAAWAVGLVLGVRNFSQQGMFIVGGTLADRLGYKPLIV 83
Cdd:cd17369   219 LVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYL 298

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1806241095  84 AGCLLRT----AGFGLLVFADSLPVMLIASAATGFAGALFNPAVRAYLA 128
Cdd:cd17369   299 AGALLAAlfafPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLA 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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