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Conserved domains on  [gi|1803606744|gb|KAF1554358|]
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Aldo-keto reductase family 1 member B10, partial [Eudyptes schlegeli]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 1-104 2.56e-52

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19107:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 307  Bit Score: 166.05  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFhpgAGLQYTFYEKPLVKGAC 80
Cdd:cd19107    14 SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKR------EDLFIV---SKLWCTFHEKGLVKGAC 84

                          90       100
                  ....*....|....*....|....
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19107    85 QKTLSDLKLDYLDLYLIHWPTGFK 108
 
Name Accession Description Interval E-value
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 1-104 2.56e-52

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 166.05  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFhpgAGLQYTFYEKPLVKGAC 80
Cdd:cd19107    14 SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKR------EDLFIV---SKLWCTFHEKGLVKGAC 84

                          90       100
                  ....*....|....*....|....
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19107    85 QKTLSDLKLDYLDLYLIHWPTGFK 108
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 5-100 4.39e-26

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 97.05  E-value: 4.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdLTIFHPGaglqytfYEKplVKGACQKT 83
Cdd:COG0656    19 EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEA----IAASGVPREElFVTTK-VWNDNHG-------YDD--TLAAFEES 84

                          90
                  ....*....|....*..
gi 1803606744  84 LANLKLHYLDLYLMHWP 100
Cdd:COG0656    85 LERLGLDYLDLYLIHWP 101
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
1-101 6.56e-14

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 65.09  E-value: 6.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQK--IRESVvkrgpFITSEDLTIFHPGAglqytfyekplvKG 78
Cdd:PRK11565   25 ASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEAsvAREEL-----FITTKLWNDDHKRP------------RE 87

                          90       100
                  ....*....|....*....|...
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWPL 101
Cdd:PRK11565   88 ALEESLKKLQLDYVDLYLMHWPV 110
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 5-100 8.43e-11

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 56.55  E-value: 8.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQ--QKIRESVvkrgpFITSE-DLTIFHPGAGLQYTFYEKplvkg 78
Cdd:pfam00248  19 EALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKdyPVKRDKV-----VIATKvPDGDGPWPSGGSKENIRK----- 88

                          90       100
                  ....*....|....*....|..
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWP 100
Cdd:pfam00248  89 SLEESLKRLGTDYIDLYYLHWP 110
 
Name Accession Description Interval E-value
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 1-104 2.56e-52

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 166.05  E-value: 2.56e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFhpgAGLQYTFYEKPLVKGAC 80
Cdd:cd19107    14 SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKR------EDLFIV---SKLWCTFHEKGLVKGAC 84

                          90       100
                  ....*....|....*....|....
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19107    85 QKTLSDLKLDYLDLYLIHWPTGFK 108
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 1-104 3.44e-39

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 132.00  E-value: 3.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFhpgAGLQYTFYEKPLVKGAC 80
Cdd:cd19110    14 ASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRR------EDLFIV---SKLWCTCHKKSLVKTAC 84

                          90       100
                  ....*....|....*....|....
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19110    85 TRSLKALKLNYLDLYLIHWPMGFK 108
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 3-104 9.77e-37

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 125.47  E-value: 9.77e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   3 AGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEDLTIFHpgaglqytfyEKPLVKGACQ 81
Cdd:cd19116    24 DEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDlFITTKLWNSYH----------EREQVEPALR 93

                          90       100
                  ....*....|....*....|...
gi 1803606744  82 KTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19116    94 ESLKRLGLDYVDLYLIHWPVAFK 116
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 1-104 3.85e-35

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 121.72  E-value: 3.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRE-SVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKG 78
Cdd:cd19106    17 SKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPgKAVPREDlFVTSK----------LWNTKHHPEDVEP 86

                          90       100
                  ....*....|....*....|....*.
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19106    87 ALRKTLKDLQLDYLDLYLIHWPYAFE 112
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 1-104 9.81e-34

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 117.90  E-value: 9.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGA 79
Cdd:cd19123    22 SKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDlWITSK----------LWNNSHAPEDVLPA 91

                          90       100
                  ....*....|....*....|....*
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19123    92 LEKTLADLQLDYLDLYLMHWPVALK 116
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-104 2.80e-31

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 110.26  E-value: 2.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRgpfitsEDLTI---FHPgaglqyTFYEKPLVK 77
Cdd:cd19071    11 LKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEA----IRESGVPR------EELFIttkLWP------TDHGYERVR 74

                          90       100
                  ....*....|....*....|....*..
gi 1803606744  78 GACQKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19071    75 EALEESLKDLGLDYLDLYLIHWPVPGK 101
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 9-104 6.46e-30

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 108.09  E-value: 6.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDltIFHPGAgLQYTFYEKPLVKGACQKTLANLK 88
Cdd:cd19108    32 ATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKR------ED--IFYTSK-LWCTFHRPELVRPALEKSLKKLQ 102

                          90
                  ....*....|....*.
gi 1803606744  89 LHYLDLYLMHWPLGFK 104
Cdd:cd19108   103 LDYVDLYLIHFPVALK 118
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 1-104 4.69e-29

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 105.51  E-value: 4.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGA 79
Cdd:cd19125    21 ADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDlFITSK----------LWCTDHAPEDVPPA 90

                          90       100
                  ....*....|....*....|....*
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19125    91 LEKTLKDLQLDYLDLYLIHWPVRLK 115
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 4-104 1.15e-28

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 104.42  E-value: 1.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   4 GQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRES-VVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQ 81
Cdd:cd19118    20 GEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEEpGVKREDlFITSK----------LWNNSHRPEYVEPALD 89

                          90       100
                  ....*....|....*....|...
gi 1803606744  82 KTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19118    90 DTLKELGLDYLDLYLIHWPVAFK 112
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 9-103 8.11e-27

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 99.52  E-value: 8.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQKTLANL 87
Cdd:cd19128    19 AVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDlFITSK----------LWPTMHQPENVKEQLLITLQDL 88

                          90
                  ....*....|....*.
gi 1803606744  88 KLHYLDLYLMHWPLGF 103
Cdd:cd19128    89 QLEYLDLFLIHWPLAF 104
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 5-100 4.39e-26

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 97.05  E-value: 4.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdLTIFHPGaglqytfYEKplVKGACQKT 83
Cdd:COG0656    19 EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEA----IAASGVPREElFVTTK-VWNDNHG-------YDD--TLAAFEES 84

                          90
                  ....*....|....*..
gi 1803606744  84 LANLKLHYLDLYLMHWP 100
Cdd:COG0656    85 LERLGLDYLDLYLIHWP 101
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 1-104 3.39e-25

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 95.64  E-value: 3.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDltIFHPGAgLQYTFYEKPLVKGAC 80
Cdd:cd19109    18 TPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKR------ED--IFYCGK-LWNTCHPPELVRPTL 88

                          90       100
                  ....*....|....*....|....
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19109    89 ERTLKVLQLDYVDLYIIEMPMAFK 112
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 7-104 1.32e-24

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 94.05  E-value: 1.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   7 TAA--VMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQKT 83
Cdd:cd19113    25 TAAdqIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREElFLTSK----------LWNNFHDPKNVETALNKT 94

                          90       100
                  ....*....|....*....|.
gi 1803606744  84 LANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19113    95 LSDLKLDYVDLFLIHFPIAFK 115
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 1-101 6.98e-24

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 91.82  E-value: 6.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGPFITSEDLTIFHPGAGLqytfyekplvkgAC 80
Cdd:cd19121    22 AKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGGVKREDLFVTTKLWSTYHRRVEL------------CL 89

                          90       100
                  ....*....|....*....|.
gi 1803606744  81 QKTLANLKLHYLDLYLMHWPL 101
Cdd:cd19121    90 DRSLKSLGLDYVDLYLVHWPV 110
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 6-104 3.35e-23

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 90.16  E-value: 3.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   6 VTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEDLTIFH-PGAglqytfyekplVKGACQKT 83
Cdd:cd19154    27 GITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDlFITTKLWTHEHaPED-----------VEEALRES 95

                          90       100
                  ....*....|....*....|.
gi 1803606744  84 LANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19154    96 LKKLQLEYVDLYLIHAPAAFK 116
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 5-104 6.46e-23

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 89.25  E-value: 6.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVK-RGP-FITSEdltifhpgagLQYTFYEKPLVKGACQK 82
Cdd:cd19124    21 DIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDElFVTSK----------LWCSDAHPDLVLPALKK 90

                          90       100
                  ....*....|....*....|..
gi 1803606744  83 TLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19124    91 SLRNLQLEYVDLYLIHWPVSLK 112
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 1-103 1.48e-22

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 88.32  E-value: 1.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEDLTIFHpgaglqytfyEKPLVKGA 79
Cdd:cd19111    14 SPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEvFITTKLPPVYL----------EFKDTEKS 83

                          90       100
                  ....*....|....*....|....
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWPLGF 103
Cdd:cd19111    84 LEKSLENLKLPYVDLYLIHHPCGF 107
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 4-104 2.77e-22

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 87.93  E-value: 2.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   4 GQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEDLTIFHpgaglqytfyekPLVKGACQK 82
Cdd:cd19112    24 GEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDlFITTKLWNSDH------------GHVIEACKD 91

                          90       100
                  ....*....|....*....|..
gi 1803606744  83 TLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19112    92 SLKKLQLDYLDLYLVHFPVATK 113
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 6-100 3.18e-21

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 84.22  E-value: 3.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   6 VTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdLTIFHPGaglqytfYEKplVKGACQKTL 84
Cdd:cd19136    17 VRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDiFITSK-LAPKDQG-------YEK--ARAACLGSL 86

                          90
                  ....*....|....*.
gi 1803606744  85 ANLKLHYLDLYLMHWP 100
Cdd:cd19136    87 ERLGTDYLDLYLIHWP 102
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 5-100 8.31e-21

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 83.09  E-value: 8.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQqkirESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQKT 83
Cdd:cd19073    15 DCANAVKEALELGYRHIDTAEIYNNEAEVGEAIA----ESGVPREDlFITTK----------VWRDHLRPEDLKKSVDRS 80

                          90
                  ....*....|....*..
gi 1803606744  84 LANLKLHYLDLYLMHWP 100
Cdd:cd19073    81 LEKLGTDYVDLLLIHWP 97
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 3-101 9.68e-21

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 83.76  E-value: 9.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   3 AGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFhpgAGLQYTFYEKPLVKGACQK 82
Cdd:cd19114    16 ANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKR------EDLFIV---TKLWNNFHGKDHVREAFDR 86

                          90
                  ....*....|....*....
gi 1803606744  83 TLANLKLHYLDLYLMHWPL 101
Cdd:cd19114    87 QLKDYGLDYIDLYLIHFPI 105
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 1-100 1.68e-20

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 82.93  E-value: 1.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPlvKGA 79
Cdd:cd19117    24 SKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQG----IKDSGVPREEiFITTK----------LWCTWHRRV--EEA 87

                          90       100
                  ....*....|....*....|.
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19117    88 LDQSLKKLGLDYVDLYLMHWP 108
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 10-104 2.13e-20

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 82.85  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  10 VMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQKTLANLK 88
Cdd:cd19115    32 VYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDlFIVSK----------LWNTFHDGERVEPICRKQLADWG 101

                          90
                  ....*....|....*.
gi 1803606744  89 LHYLDLYLMHWPLGFK 104
Cdd:cd19115   102 IDYFDLFLIHFPIALK 117
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 2-101 3.39e-20

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 82.28  E-value: 3.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRE--SVVKRGPFITSEDLTIFHPgaglqytfYEKplVKGA 79
Cdd:cd19122    22 AKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKEnpSVKREDLFICTKVWNHLHE--------PED--VKWS 91

                          90       100
                  ....*....|....*....|..
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWPL 101
Cdd:cd19122    92 IDNSLKNLKLDYIDLFLVHWPI 113
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 9-102 1.02e-19

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 80.31  E-value: 1.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdLTIfhpgaglQYTFYEKplVKGACQKTLANL 87
Cdd:cd19133    28 AVLEAIKAGYRLIDTAAAYGNEEAVGRA----IKKSGIPREElFITTK-LWI-------QDAGYEK--AKKAFERSLKRL 93

                          90
                  ....*....|....*
gi 1803606744  88 KLHYLDLYLMHWPLG 102
Cdd:cd19133    94 GLDYLDLYLIHQPFG 108
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 9-100 4.57e-19

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 78.81  E-value: 4.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltiFHPGAglqytfyekPLVKGACQKTLANL 87
Cdd:cd19120    30 SVKLALKAGFRHIDTAEMYGNEKEVGEA----LKESGVPREDlFITTK----VSPGI---------KDPREALRKSLAKL 92

                          90
                  ....*....|...
gi 1803606744  88 KLHYLDLYLMHWP 100
Cdd:cd19120    93 GVDYVDLYLIHSP 105
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 4-100 9.10e-19

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 77.68  E-value: 9.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   4 GQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltIFHPGaglqytfYEKPLVKGACQK 82
Cdd:cd19140    21 EECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDElFLTTK---VWPDN-------YSPDDFLASVEE 86

                          90
                  ....*....|....*...
gi 1803606744  83 TLANLKLHYLDLYLMHWP 100
Cdd:cd19140    87 SLRKLRTDYVDLLLLHWP 104
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 9-104 9.89e-19

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 78.27  E-value: 9.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIfhpGAGLQYTFYEKPLVKGACQKTLANLK 88
Cdd:cd19129    24 AVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRR------EDLFV---TTKLWNTNHRPERVKPAFEASLKRLQ 94

                          90
                  ....*....|....*.
gi 1803606744  89 LHYLDLYLMHWPLGFK 104
Cdd:cd19129    95 LDYLDLYLIHTPFAFQ 110
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 4-104 1.31e-18

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 77.92  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   4 GQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRGP-FITsedlTIFHPgaglqyTFYEKplVKGACQK 82
Cdd:cd19119    27 AEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREElFIT----TKVWP------TFYDE--VERSLDE 94

                          90       100
                  ....*....|....*....|..
gi 1803606744  83 TLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19119    95 SLKALGLDYVDLLLVHWPVCFE 116
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 1-103 1.60e-18

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 77.95  E-value: 1.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQKIRESVVKRgpfitsEDLTIFH--PGAGLQYTFYEKPLvkg 78
Cdd:cd19155    22 SSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKR------EELFIVTklPPGGNRREKVEKFL--- 92

                          90       100
                  ....*....|....*....|....*
gi 1803606744  79 acQKTLANLKLHYLDLYLMHWPLGF 103
Cdd:cd19155    93 --LKSLEKLQLDYVDLYLIHFPVGS 115
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 1-100 4.04e-18

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 76.29  E-value: 4.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdLTIFHPGaglqytfYEKPLVkgA 79
Cdd:cd19127    19 TPPEETADAVATALADGYRLIDTAAAYGNEREVGEG----IRRSGVDRSDiFVTTK-LWISDYG-------YDKALR--G 84

                          90       100
                  ....*....|....*....|.
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19127    85 FDASLRRLGLDYVDLYLLHWP 105
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 5-104 9.92e-18

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 75.12  E-value: 9.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltIFHPGAGlqytfYEKPLvkGACQKT 83
Cdd:cd19157    25 EVVNAVKTALKNGYRSIDTAAIYGNEEGVGKG----IKESGIPREElFITSK---VWNADQG-----YDSTL--KAFEAS 90

                          90       100
                  ....*....|....*....|.
gi 1803606744  84 LANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19157    91 LERLGLDYLDLYLIHWPVKGK 111
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 1-104 2.09e-17

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 74.48  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTA-AVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltIFHPGAGlqytfYEKPLvkG 78
Cdd:cd19156    19 VQDGAEAEnAVKWAIEAGYRHIDTAAIYKNEEGVGQG----IRESGVPREEvFVTTK---LWNSDQG-----YESTL--A 84

                          90       100
                  ....*....|....*....|....*.
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWPLGFK 104
Cdd:cd19156    85 AFEESLEKLGLDYVDLYLIHWPVKGK 110
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 5-101 5.60e-17

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 73.18  E-value: 5.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltIFHPGAGlqytfYEKPLvkGACQKT 83
Cdd:cd19131    24 EAASAVREALEVGYRSIDTAAIYGNEEGVGKA----IRASGVPREElFITTK---LWNSDQG-----YDSTL--RAFDES 89

                          90
                  ....*....|....*...
gi 1803606744  84 LANLKLHYLDLYLMHWPL 101
Cdd:cd19131    90 LRKLGLDYVDLYLIHWPV 107
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 9-100 1.33e-16

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 72.08  E-value: 1.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITS----EDLTifhpgaglqytfYEKplVKGACQKT 83
Cdd:cd19126    28 AVQTALENGYRSIDTAAIYKNEEGVGEA----IRESGVPREElFVTTklwnDDQR------------ARR--TEDAFQES 89

                          90
                  ....*....|....*..
gi 1803606744  84 LANLKLHYLDLYLMHWP 100
Cdd:cd19126    90 LDRLGLDYVDLYLIHWP 106
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 5-101 1.66e-16

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 71.92  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltifHPGAglqYTFYEKplVKGACQKT 83
Cdd:cd19132    21 EGVEAVVAALQAGYRLLDTAFNYENEGAVGEA----VRRSGVPREElFVTTK-----LPGR---HHGYEE--ALRTIEES 86

                          90
                  ....*....|....*...
gi 1803606744  84 LANLKLHYLDLYLMHWPL 101
Cdd:cd19132    87 LYRLGLDYVDLYLIHWPN 104
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 9-102 6.36e-16

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 70.27  E-value: 6.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   9 AVMAAIHAGYRHFDCAYVYQNEKEVGEGIqqkiRESVVKRGP-FITSEDLTifhPGAGLQYTfyekplvKGACQKTLANL 87
Cdd:cd19134    29 SVSAALEAGYRLIDTAAAYGNEAAVGRAI----AASGIPRGElFVTTKLAT---PDQGFTAS-------QAACRASLERL 94

                          90
                  ....*....|....*
gi 1803606744  88 KLHYLDLYLMHWPLG 102
Cdd:cd19134    95 GLDYVDLYLIHWPAG 109
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 2-101 1.26e-14

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 66.96  E-value: 1.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAI-HAGYRHFDCAYVYQNEKEVGEGIqqkiRESVVKRGP-FITSEdltIFHPGAGlqytfYEKplVKGA 79
Cdd:cd19135    23 SGGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAI----KESGVPREDlFLTTK---LWPSDYG-----YES--TKQA 88

                          90       100
                  ....*....|....*....|..
gi 1803606744  80 CQKTLANLKLHYLDLYLMHWPL 101
Cdd:cd19135    89 FEASLKRLGVDYLDLYLLHWPD 110
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 6-100 5.64e-14

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 65.07  E-value: 5.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   6 VTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGiqqkIRESVVKRGP-FITSEdltifhpgagLQYTFYEKPLVKGACQKTL 84
Cdd:cd19139    16 VIDSVRTALELGYRHIDTAQIYDNEAAVGQA----IAESGVPRDElFITTK----------IWIDNLSKDKLLPSLEESL 81

                          90
                  ....*....|....*.
gi 1803606744  85 ANLKLHYLDLYLMHWP 100
Cdd:cd19139    82 EKLRTDYVDLTLIHWP 97
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
1-101 6.56e-14

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 65.09  E-value: 6.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQK--IRESVvkrgpFITSEDLTIFHPGAglqytfyekplvKG 78
Cdd:PRK11565   25 ASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEAsvAREEL-----FITTKLWNDDHKRP------------RE 87

                          90       100
                  ....*....|....*....|...
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWPL 101
Cdd:PRK11565   88 ALEESLKKLQLDYVDLYLMHWPV 110
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 13-100 1.36e-13

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 64.17  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  13 AIHAGYRHFDCAYVYQN---EKEVGEGIQQKIRESVvkrgpFITSEdLTIFHpgaglqYTFYEkplVKGACQKTLANLKL 89
Cdd:cd19072    35 AIELGINLIDTAEMYGGghaEELVGKAIKGFDREDL-----FITTK-VSPDH------LKYDD---VIKAAKESLKRLGT 99

                          90
                  ....*....|.
gi 1803606744  90 HYLDLYLMHWP 100
Cdd:cd19072   100 DYIDLYLIHWP 110
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 5-100 1.82e-11

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 58.37  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQqKIRESVVkrgpfITSEdltifhpgAGLQYTFYEkpLVKGACQ 81
Cdd:cd19085    24 ESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALK-GRRDDVV-----IATK--------VSPDNLTPE--DVRKSCE 87

                          90
                  ....*....|....*....
gi 1803606744  82 KTLANLKLHYLDLYLMHWP 100
Cdd:cd19085    88 RSLKRLGTDYIDLYQIHWP 106
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 5-101 3.49e-11

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 57.61  E-value: 3.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQNEKEVGEGIQQkirESVVKRGPFITSEDLTIFHPGaglqytfyEKPLvkGACQKTL 84
Cdd:cd19130    24 DTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAA---SGIPRDELFVTTKLWNDRHDG--------DEPA--AAFAESL 90

                          90
                  ....*....|....*..
gi 1803606744  85 ANLKLHYLDLYLMHWPL 101
Cdd:cd19130    91 AKLGLDQVDLYLVHWPT 107
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 5-100 8.43e-11

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 56.55  E-value: 8.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQ--QKIRESVvkrgpFITSE-DLTIFHPGAGLQYTFYEKplvkg 78
Cdd:pfam00248  19 EALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKdyPVKRDKV-----VIATKvPDGDGPWPSGGSKENIRK----- 88

                          90       100
                  ....*....|....*....|..
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWP 100
Cdd:pfam00248  89 SLEESLKRLGTDYIDLYYLHWP 110
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
4-100 8.59e-11

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 56.57  E-value: 8.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   4 GQ-VTAAVMAAIHAGYRHFDCAYVYQNEKEVGegiqQKIRESVVKRGP-FITSEdLTIFHPGAGlqytfyekPLVKgACQ 81
Cdd:PRK11172   15 DQvVIDSVKTALELGYRAIDTAQIYDNEAAVG----QAIAESGVPRDElFITTK-IWIDNLAKD--------KLIP-SLK 80

                          90
                  ....*....|....*....
gi 1803606744  82 KTLANLKLHYLDLYLMHWP 100
Cdd:PRK11172   81 ESLQKLRTDYVDLTLIHWP 99
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 8-100 9.34e-11

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 55.99  E-value: 9.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   8 AAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQ-KIRESVVkrgpfITSedlTIFHPGAGLQYTF-YEKPLVKGACQK 82
Cdd:cd06660    21 ALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGrGNRDDVV-----IAT---KGGHPPGGDPSRSrLSPEHIRRDLEE 92

                          90
                  ....*....|....*...
gi 1803606744  83 TLANLKLHYLDLYLMHWP 100
Cdd:cd06660    93 SLRRLGTDYIDLYYLHRD 110
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 1-100 2.19e-10

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 55.33  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQkIRESVvkrgpFITSEDLtifhPG-AGLQYTFYekplv 76
Cdd:cd19138    26 AKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRG-RRDKV-----FLVSKVL----PSnASRQGTVR----- 90

                          90       100
                  ....*....|....*....|....
gi 1803606744  77 kgACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19138    91 --ACERSLRRLGTDYLDLYLLHWR 112
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 5-100 5.95e-10

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 54.41  E-value: 5.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVV-------KRGPFITSEDLTIFHpgaglqytfyekp 74
Cdd:COG0667    34 EAIAILDAALDAGINFFDTADVYgpgRSEELLGEALKGRPRDDVViatkvgrRMGPGPNGRGLSREH------------- 100

                          90       100
                  ....*....|....*....|....*.
gi 1803606744  75 lVKGACQKTLANLKLHYLDLYLMHWP 100
Cdd:COG0667   101 -IRRAVEASLRRLGTDYIDLYQLHRP 125
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 5-100 3.00e-08

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 49.49  E-value: 3.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVvkrgpFITSEdltIFHpgAGLQYTFYEKPLvkgacQ 81
Cdd:cd19137    27 EMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKDFPREDL-----FIVTK---VWP--TNLRYDDLLRSL-----Q 91

                          90
                  ....*....|....*....
gi 1803606744  82 KTLANLKLHYLDLYLMHWP 100
Cdd:cd19137    92 NSLRRLDTDYIDLYLIHWP 110
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 1-100 5.56e-08

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 48.76  E-value: 5.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   1 SSAGQVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQ-KIRESVVKRGPFitsedltifhpgAGLQYTFYEKPLV 76
Cdd:cd19093    23 YGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKElGDRDEVVIATKF------------APLPWRLTRRSVV 90

                          90       100
                  ....*....|....*....|....
gi 1803606744  77 KgACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19093    91 K-ALKASLERLGLDSIDLYQLHWP 113
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 8-100 1.19e-07

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 47.91  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   8 AAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQqKIRESVV--------KRGPFITSEDLTifhPGAglqytfyekplV 76
Cdd:cd19084    29 EAIKAAIDLGINFFDTAPVYGFghsEEILGKALK-GRRDDVViatkcglrWDGGKGVTKDLS---PES-----------I 93

                          90       100
                  ....*....|....*....|....
gi 1803606744  77 KGACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19084    94 RKEVEQSLRRLQTDYIDLYQIHWP 117
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
 2-101 2.23e-07

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 46.70  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQKiRESVV---KRGPfitsedltIFHPGAGLQYTFyEKPL 75
Cdd:cd19086    22 DDAEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKGR-RDKVViatKFGN--------RFDGGPERPQDF-SPEY 91

                          90       100
                  ....*....|....*....|....*..
gi 1803606744  76 VKGACQKTLANLKLHYLDLYLMH-WPL 101
Cdd:cd19086    92 IREAVEASLKRLGTDYIDLYQLHnPPD 118
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 10-100 1.17e-06

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 45.10  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  10 VMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVV--KRGPFITSEDLTIFHPgaglqytfyEKPLVKGACQKTL 84
Cdd:cd19083    39 VREALDNGVNLLDTAFIYglgRSEELVGEVLKEYNRNEVViaTKGAHKFGGDGSVLNN---------SPEFLRSAVEKSL 109

                          90
                  ....*....|....*.
gi 1803606744  85 ANLKLHYLDLYLMHWP 100
Cdd:cd19083   110 KRLNTDYIDLYYIHFP 125
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 8-98 2.01e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 44.11  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   8 AAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQKIRESVvkrgpFITSedltifhpGAGLQYTFYEKPLVKGACQKTL 84
Cdd:cd19105    29 ELLRRALDLGINYFDTAEGYGNgnsEEIIGEALKGLRRDKV-----FLAT--------KASPRLDKKDKAELLKSVEESL 95

                          90
                  ....*....|....
gi 1803606744  85 ANLKLHYLDLYLMH 98
Cdd:cd19105    96 KRLQTDYIDIYQLH 109
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 13-98 2.04e-06

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 44.13  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  13 AIHAGYRHFDCAYVYQ---NEKEVGEGIQQKiRESVV---KRGPFITSEDLTIFHPGaglqytfyeKP-LVKGACQKTLA 85
Cdd:cd19076    41 ALELGVTFLDTADMYGpgtNEELLGKALKDR-RDEVViatKFGIVRDPGSGFRGVDG---------RPeYVRAACEASLK 110

                          90
                  ....*....|...
gi 1803606744  86 NLKLHYLDLYLMH 98
Cdd:cd19076   111 RLGTDVIDLYYQH 123
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 13-98 7.15e-06

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 42.80  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  13 AIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVvkrgpfitsEDLTIFhpgaGLQYTFYEKPLVKG-------ACQK 82
Cdd:cd19145    42 AFNSGVTFLDTSDIYgpnTNEVLLGKALKDGPREKV---------QLATKF----GIHEIGGSGVEVRGdpayvraACEA 108

                          90
                  ....*....|....*.
gi 1803606744  83 TLANLKLHYLDLYLMH 98
Cdd:cd19145   109 SLKRLDVDYIDLYYQH 124
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 5-100 1.13e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 42.31  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQKIRESVVKR--------GPFITSEDLTIFHPGAGLQYTFYEK 73
Cdd:cd19099    22 EYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRdevvivtkAGYIPGDGDEPLRPLKYLEEKLGRG 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1803606744  74 PLVKG----------------ACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19099   102 LIDVAdsaglrhcispayledQIERSLKRLGLDTIDLYLLHNP 144
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
5-98 7.20e-05

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 39.80  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY-QNEKEVGEGIQqKIRESVvkrgpFITSEDLTIFHPGAGLQYTFyekplvkgacQKT 83
Cdd:COG1453    30 EAEALIRRAIDNGINYIDTARGYgDSEEFLGKALK-GPRDKV-----ILATKLPPWVRDPEDMRKDL----------EES 93

                          90
                  ....*....|....*
gi 1803606744  84 LANLKLHYLDLYLMH 98
Cdd:COG1453    94 LKRLQTDYIDLYLIH 108
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 5-99 7.86e-05

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 39.85  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   5 QVTAAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVvkrgpFITSEdltiFHPGAGLQYTFYEKPLvkgacQ 81
Cdd:cd19096    22 KAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEALKEGPREKF-----YLATK----LPPWSVKSAEDFRRIL-----E 87

                          90
                  ....*....|....*...
gi 1803606744  82 KTLANLKLHYLDLYLMHW 99
Cdd:cd19096    88 ESLKRLGVDYIDFYLLHG 105
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 8-102 9.36e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 39.58  E-value: 9.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   8 AAVMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKIRESVV--KRGPFITSEdltifhpgaGLQYTFYEKPLVKGACQK 82
Cdd:cd19102    30 AAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGLRDRPIVatKCGLLWDEE---------GRIRRSLKPASIRAECEA 100

                          90       100
                  ....*....|....*....|
gi 1803606744  83 TLANLKLHYLDLYLMHWPLG 102
Cdd:cd19102   101 SLRRLGVDVIDLYQIHWPDP 120
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 2-100 1.87e-04

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 38.69  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQK--IRESVV---KRGPFITSEDltifHPGAGLQYTFyEK 73
Cdd:cd19092    22 SAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALNpgLREKIEiqtKCGIRLGDDP----RPGRIKHYDT-SK 96

                          90       100
                  ....*....|....*....|....*..
gi 1803606744  74 PLVKGACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19092    97 EHILASVEGSLKRLGTDYLDLLLLHRP 123
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 2-100 6.33e-04

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 37.31  E-value: 6.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYqnekevGEGIQQKIRESVVKRGPfitSEDLTI---FHPGAGLQYtfyEKPLVKg 78
Cdd:cd19103    30 DEDTLKAVFDKAMAAGLNLWDTAAVY------GMGASEKILGEFLKRYP---REDYIIstkFTPQIAGQS---ADPVAD- 96

                          90       100
                  ....*....|....*....|..
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19103    97 MLEGSLARLGTDYIDIYWIHNP 118
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 13-100 1.30e-03

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 36.39  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  13 AIHAGYRHFDCAYVY----------QNEKEVGEGIQQK-IRESVV---KrgpfITSEDLTIFHPGAGLqyTFYEKPLVKG 78
Cdd:cd19094    27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKKgNRDKVVlatK----VAGPGEGITWPRGGG--TRLDRENIRE 100

                          90       100
                  ....*....|....*....|..
gi 1803606744  79 ACQKTLANLKLHYLDLYLMHWP 100
Cdd:cd19094   101 AVEGSLKRLGTDYIDLYQLHWP 122
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 12-100 1.68e-03

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 36.10  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  12 AAIHAGYRH----FDCAYVYQN---EKEVGEGIQQKiRESVV---KRGPFITSEDLTIFHPGAGLQYTFYEKP-LVKGAC 80
Cdd:cd19149    37 RTIHAALDLginlIDTAPAYGFghsEEIVGKAIKGR-RDKVVlatKCGLRWDREGGSFFFVRDGVTVYKNLSPeSIREEV 115

                          90       100
                  ....*....|....*....|
gi 1803606744  81 QKTLANLKLHYLDLYLMHWP 100
Cdd:cd19149   116 EQSLKRLGTDYIDLYQTHWQ 135
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 10-99 2.13e-03

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 35.67  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  10 VMAAIHAGYRHFDCAYVY---QNEKEVGEGIQQKiRESVV--KRGPFITSEDLTifHPGAGLQYTFYekplvkgACQKTL 84
Cdd:cd19091    45 VDIALDAGINFFDTADVYsegESEEILGKALKGR-RDDVLiaTKVRGRMGEGPN--DVGLSRHHIIR-------AVEASL 114

                          90
                  ....*....|....*
gi 1803606744  85 ANLKLHYLDLYLMHW 99
Cdd:cd19091   115 KRLGTDYIDLYQLHG 129
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
 16-98 2.18e-03

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 35.61  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  16 AGYRHFDCAYVYQN-------EKEVGEGIQQ-KIRESVV---KRGpfitsedltifHPGaglqYTFYEKPLVKGAC---- 80
Cdd:cd19082    29 LGGNFIDTARVYGDwvergasERVIGEWLKSrGNRDKVViatKGG-----------HPD----LEDMSRSRLSPEDirad 93

                          90
                  ....*....|....*....
gi 1803606744  81 -QKTLANLKLHYLDLYLMH 98
Cdd:cd19082    94 lEESLERLGTDYIDLYFLH 112
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
 2-63 3.42e-03

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 34.89  E-value: 3.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYQN---EKEVGEGIQQKIRESVV---KRGPFI--TSEDLTIFHPG 63
Cdd:cd19152    18 SDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALRELGREDYVistKVGRLLvpLQEVEPTFEPG 87
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 2-98 6.75e-03

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 33.99  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744   2 SAGQVTAAVMAAIHAGYRHFDCAYVYQN-EKEVGEGIQQKiRESVvkrgpFITSedltifhpgaglQYTFYEKPLVKGAC 80
Cdd:cd19100    25 SQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR-RDKV-----FLAT------------KTGARDYEGAKRDL 86

                          90
                  ....*....|....*...
gi 1803606744  81 QKTLANLKLHYLDLYLMH 98
Cdd:cd19100    87 ERSLKRLGTDYIDLYQLH 104
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 12-100 7.87e-03

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 34.04  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803606744  12 AAIHAGYRHFDCAYVYQN-EKEVGEGIQQKIRESVVKRGPFITSEDLTIfhpgaglqytfyeKPLVKGACQKTLANLKLH 90
Cdd:cd19097    34 YALKAGINTLDTAPAYGDsEKVLGKFLKRLDKFKIITKLPPLKEDKKED-------------EAAIEASVEASLKRLKVD 100

                          90
                  ....*....|
gi 1803606744  91 YLDLYLMHWP 100
Cdd:cd19097   101 SLDGLLLHNP 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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