|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
41-473 |
1.50e-146 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 426.91 E-value: 1.50e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 41 VPQSEHGIDPNLLDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFIIGRRFRIVHV 120
Cdd:TIGR01942 2 IPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVHV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 121 VYGRgrehEVIEVSTFRAyldpnaaeqvagnektskrelADKSHVvDASGRVLRDNVWGPQDQDAARRDFTVNAMYYDPH 200
Cdd:TIGR01942 82 SFGR----QIIEVATFRS---------------------GHKSSV-NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPS 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 201 TGVVVDYHGGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKL 280
Cdd:TIGR01942 136 REVIIDYVGGMEDLKNRRLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 281 LQTGHAQASLAELRKQGLDRGVFPILDAVFDESRRHPGrDRFVQLALADTDRRVAEDKPVAPSFLLACLLWHDVLAHWQR 360
Cdd:TIGR01942 216 LFSGRSAALFRMLCGYQLLEPLFPSVAYALRESPKFES-AFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVAD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 361 YQAQGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGEA 440
Cdd:TIGR01942 295 APDQGVMPYPAVFDAIRDFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE 374
|
410 420 430
....*....|....*....|....*....|...
gi 1803102895 441 ETALADWWERFSLADDGERRQLLQEAREQEAMR 473
Cdd:TIGR01942 375 NAVLGEWWTPYQLASEEERTEMTRSAARHEGNR 407
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
41-474 |
1.62e-116 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 352.52 E-value: 1.62e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 41 VPQSEHGIDPNLLDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFIIGRRFRIVHV 120
Cdd:PRK11623 39 IPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 121 VYGRgrehEVIEVSTFRAYldpnaAEQVAGNEKTSKReladkshvvDASGRVLRDNVWGPQDQDAARRDFTVNAMYYDPH 200
Cdd:PRK11623 119 MFGP----EIIEVATFRGH-----HEGNESDRNTSQR---------GQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 201 TGVVVDYHGGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKL 280
Cdd:PRK11623 181 DFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 281 LQTGHAQASLAELRKQGLDRGVFPILDAVFDESRRHPgRDRFVQLALADTDRRVAEDKPVAPSFLLACLLWHDVLAHWQR 360
Cdd:PRK11623 261 LQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSP-MERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQK 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 361 Y-QAQGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGE 439
Cdd:PRK11623 340 IaQESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVEN 419
|
410 420 430
....*....|....*....|....*....|....*..
gi 1803102895 440 AE--TALADWWERFSLADDGERRQLLQEAREQEAMRR 474
Cdd:PRK11623 420 NAelQRLAQWWGEFQVSAPPQQKGMLNELDDDPAPRR 456
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
53-454 |
3.98e-107 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 325.23 E-value: 3.98e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 53 LDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFR---RAFIIGRRFRIVHVVYGRgrehE 129
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGG----E 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 130 VIEVSTFRAyldpnaaeqvagnektskreladksHVVDASGRvLRDNVWGP-QDQDAARRDFTVNAMYYDPHTGVVVDYH 208
Cdd:COG0617 78 KIEVATART-------------------------ERYYGDGR-RPFVEFGDtLEEDLARRDFTINALAYDLNDGELIDPF 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 209 GGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKLLQTGHAQA 288
Cdd:COG0617 132 GGLADLEARVIRTVGDPEERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 289 SLAELRKQGLdrgvFPILdavfdesrrhpgrdrfvqlaladtdrrvaedkpvapSFLLACLLwHDVLAHWQRyqAQGEPA 368
Cdd:COG0617 212 GLELLRETGL----LEVL------------------------------------ALRLAALL-HDLGKPATR--EDGLPT 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 369 FPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVE--QPRFRAGFDFLRLRAQAGEAETALAD 446
Cdd:COG0617 249 FHGHEEAGAELAEALLKRLRLPNRERKLVRELVELHLRFHGLGELRDSAVRRllERGPEALEDLLLLRENGLEYPELQER 328
|
....*...
gi 1803102895 447 WWERFSLA 454
Cdd:COG0617 329 LAELLEAA 336
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
364-474 |
5.93e-42 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 145.81 E-value: 5.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 364 QGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGEAETA 443
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100 110
....*....|....*....|....*....|.
gi 1803102895 444 LADWWERFSLADDGERRQLLQEAREQEAMRR 474
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMIAELGADAAKKK 111
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
54-216 |
3.99e-36 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 131.18 E-value: 3.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 54 DDRARRVVETLQEA-GYEAYIVGGAVRDLILGHRPKDFDVATNA-TPEQVKALFR----RAFIIGRRFRIVHVVYGRGRe 127
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiggRVVGLGEEFGTATVVINGLT- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 128 hevIEVSTFRayldpnaaeqvagnektskreladkSHVVDASGRVLRDNVWGPqDQDAARRDFTVNAMYYDPHTGVVVDY 207
Cdd:cd05398 80 ---IDVATLR-------------------------TETYTDPGRRPPVVGFTI-EEDLLRRDFTINAMAYDLDDGELIDP 130
|
....*....
gi 1803102895 208 HGGIKDAKK 216
Cdd:cd05398 131 FGGLKDLEN 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pcnB |
TIGR01942 |
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ... |
41-473 |
1.50e-146 |
|
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).
Pssm-ID: 130997 [Multi-domain] Cd Length: 410 Bit Score: 426.91 E-value: 1.50e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 41 VPQSEHGIDPNLLDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFIIGRRFRIVHV 120
Cdd:TIGR01942 2 IPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVHV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 121 VYGRgrehEVIEVSTFRAyldpnaaeqvagnektskrelADKSHVvDASGRVLRDNVWGPQDQDAARRDFTVNAMYYDPH 200
Cdd:TIGR01942 82 SFGR----QIIEVATFRS---------------------GHKSSV-NAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPS 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 201 TGVVVDYHGGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKL 280
Cdd:TIGR01942 136 REVIIDYVGGMEDLKNRRLRLIGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 281 LQTGHAQASLAELRKQGLDRGVFPILDAVFDESRRHPGrDRFVQLALADTDRRVAEDKPVAPSFLLACLLWHDVLAHWQR 360
Cdd:TIGR01942 216 LFSGRSAALFRMLCGYQLLEPLFPSVAYALRESPKFES-AFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVAD 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 361 YQAQGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGEA 440
Cdd:TIGR01942 295 APDQGVMPYPAVFDAIRDFVEEQCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRE 374
|
410 420 430
....*....|....*....|....*....|...
gi 1803102895 441 ETALADWWERFSLADDGERRQLLQEAREQEAMR 473
Cdd:TIGR01942 375 NAVLGEWWTPYQLASEEERTEMTRSAARHEGNR 407
|
|
| pcnB |
PRK11623 |
poly(A) polymerase I; Provisional |
41-474 |
1.62e-116 |
|
poly(A) polymerase I; Provisional
Pssm-ID: 236939 [Multi-domain] Cd Length: 472 Bit Score: 352.52 E-value: 1.62e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 41 VPQSEHGIDPNLLDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFIIGRRFRIVHV 120
Cdd:PRK11623 39 IPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 121 VYGRgrehEVIEVSTFRAYldpnaAEQVAGNEKTSKReladkshvvDASGRVLRDNVWGPQDQDAARRDFTVNAMYYDPH 200
Cdd:PRK11623 119 MFGP----EIIEVATFRGH-----HEGNESDRNTSQR---------GQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 201 TGVVVDYHGGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKL 280
Cdd:PRK11623 181 DFTVRDYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 281 LQTGHAQASLAELRKQGLDRGVFPILDAVFDESRRHPgRDRFVQLALADTDRRVAEDKPVAPSFLLACLLWHDVLAHWQR 360
Cdd:PRK11623 261 LQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSP-MERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLEHAQK 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 361 Y-QAQGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGE 439
Cdd:PRK11623 340 IaQESGLAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVEN 419
|
410 420 430
....*....|....*....|....*....|....*..
gi 1803102895 440 AE--TALADWWERFSLADDGERRQLLQEAREQEAMRR 474
Cdd:PRK11623 420 NAelQRLAQWWGEFQVSAPPQQKGMLNELDDDPAPRR 456
|
|
| PcnB |
COG0617 |
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ... |
53-454 |
3.98e-107 |
|
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440382 [Multi-domain] Cd Length: 391 Bit Score: 325.23 E-value: 3.98e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 53 LDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFR---RAFIIGRRFRIVHVVYGRgrehE 129
Cdd:COG0617 2 LSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGG----E 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 130 VIEVSTFRAyldpnaaeqvagnektskreladksHVVDASGRvLRDNVWGP-QDQDAARRDFTVNAMYYDPHTGVVVDYH 208
Cdd:COG0617 78 KIEVATART-------------------------ERYYGDGR-RPFVEFGDtLEEDLARRDFTINALAYDLNDGELIDPF 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 209 GGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKLLQTGHAQA 288
Cdd:COG0617 132 GGLADLEARVIRTVGDPEERFREDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 289 SLAELRKQGLdrgvFPILdavfdesrrhpgrdrfvqlaladtdrrvaedkpvapSFLLACLLwHDVLAHWQRyqAQGEPA 368
Cdd:COG0617 212 GLELLRETGL----LEVL------------------------------------ALRLAALL-HDLGKPATR--EDGLPT 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 369 FPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVE--QPRFRAGFDFLRLRAQAGEAETALAD 446
Cdd:COG0617 249 FHGHEEAGAELAEALLKRLRLPNRERKLVRELVELHLRFHGLGELRDSAVRRllERGPEALEDLLLLRENGLEYPELQER 328
|
....*...
gi 1803102895 447 WWERFSLA 454
Cdd:COG0617 329 LAELLEAA 336
|
|
| PRK13299 |
PRK13299 |
tRNA CCA-pyrophosphorylase; Provisional |
56-298 |
9.57e-60 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237339 [Multi-domain] Cd Length: 394 Bit Score: 202.38 E-value: 9.57e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 56 RARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFIIGRRFRIVHVVYgrgrEHEVIEVST 135
Cdd:PRK13299 8 KALPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVDVGIEHGTVLVLE----NGEEYEVTT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 136 FRA---YLDPNAAEQVagnekTSKRELadkshvvdasgrvlrdnvwgpqDQDAARRDFTVNAMYYDPHtGVVVDYHGGIK 212
Cdd:PRK13299 84 FRTeseYVDYRRPSEV-----TFVRSL----------------------EEDLKRRDFTINAIAMDEN-GEIIDLFDGLE 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 213 DAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKLLQTGHAQASLAE 292
Cdd:PRK13299 136 DLKNRLIRAVGNAEERFQEDALRMMRAVRFASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKL 215
|
....*.
gi 1803102895 293 LRKQGL 298
Cdd:PRK13299 216 LIETGL 221
|
|
| PolyA_pol_arg_C |
pfam12626 |
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ... |
364-474 |
5.93e-42 |
|
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.
Pssm-ID: 463647 [Multi-domain] Cd Length: 116 Bit Score: 145.81 E-value: 5.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 364 QGEPAFPALQSAIDEVFNARVGDISGRGKLGADMREIWSMQPRFDRRVGNGPFTLVEQPRFRAGFDFLRLRAQAGEAETA 443
Cdd:pfam12626 1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80
|
90 100 110
....*....|....*....|....*....|.
gi 1803102895 444 LADWWERFSLADDGERRQLLQEAREQEAMRR 474
Cdd:pfam12626 81 LAEWWTRFQEADEAEREAMIAELGADAAKKK 111
|
|
| PolyA_pol |
pfam01743 |
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ... |
71-220 |
5.64e-39 |
|
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.
Pssm-ID: 396348 [Multi-domain] Cd Length: 126 Bit Score: 138.18 E-value: 5.64e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 71 AYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRRAFII----GRRFRIVHVVYGrgreHEVIEVSTFRAYLDpnaaE 146
Cdd:pfam01743 1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFG----NQILEVATFRIEFD----E 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1803102895 147 QVAGNEKTSKReladkshvvdaSGRVlrdnvwgpqDQDAARRDFTVNAMYYDPHTGVVVDYHGGIKDAKKRVLR 220
Cdd:pfam01743 73 SDFRNPRSEEY-----------TGTL---------EEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
|
|
| NT_ClassII-CCAase |
cd05398 |
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ... |
54-216 |
3.99e-36 |
|
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.
Pssm-ID: 143388 [Multi-domain] Cd Length: 139 Bit Score: 131.18 E-value: 3.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 54 DDRARRVVETLQEA-GYEAYIVGGAVRDLILGHRPKDFDVATNA-TPEQVKALFR----RAFIIGRRFRIVHVVYGRGRe 127
Cdd:cd05398 1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiggRVVGLGEEFGTATVVINGLT- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 128 hevIEVSTFRayldpnaaeqvagnektskreladkSHVVDASGRVLRDNVWGPqDQDAARRDFTVNAMYYDPHTGVVVDY 207
Cdd:cd05398 80 ---IDVATLR-------------------------TETYTDPGRRPPVVGFTI-EEDLLRRDFTINAMAYDLDDGELIDP 130
|
....*....
gi 1803102895 208 HGGIKDAKK 216
Cdd:cd05398 131 FGGLKDLEN 139
|
|
| tRNA_CCA_actino |
TIGR02692 |
tRNA adenylyltransferase; The enzyme tRNA adenylyltransferase, also called ... |
50-316 |
4.79e-32 |
|
tRNA adenylyltransferase; The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 131739 [Multi-domain] Cd Length: 466 Bit Score: 128.30 E-value: 4.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 50 PNLLDDRARRVVETLQEAGYEAYIVGGAVRDLILGHRPKDFDVATNATPEQVKALFRR----AFIIGRRFRIVhvvyGRG 125
Cdd:TIGR02692 9 LGELSPLLAPLAAAFAAAGHELYLVGGSVRDALLGRLGHDLDFTTDARPEETLAILRPwadaVWDTGIAFGTV----GAE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 126 REHEVIEVSTFRAyldpnaaEQVAGNEKTSKRELADKshvvdasgrvlrdnvwgpQDQDAARRDFTVNAMYYD---PHTG 202
Cdd:TIGR02692 85 KDGQQIEITTFRS-------DSYDGTSRKPEVTFGDT------------------LEGDLIRRDFTVNAMAVRipaDGSL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 203 VVVDYHGGIKDAKKRVLRMIGDPATRYREDPVRIIRVVRFAAKLGFDIDPRTREPIREMAALLENVPQSRLFDEMVKLLQ 282
Cdd:TIGR02692 140 EFHDPVGGLDDLLAKVLDTPATPEQSFGDDPLRMLRAARFVSQLGFEVAPRVRAAMTEMADQIERISAERVRVELDKLLL 219
|
250 260 270
....*....|....*....|....*....|....*..
gi 1803102895 283 TGHAQASLAELRKQGLDRGVFPILDAV---FDESRRH 316
Cdd:TIGR02692 220 GDHPRAGIDLMVETGLADRVLPEIPALrleIDEHHQH 256
|
|
| cca |
PRK10885 |
multifunctional CCA addition/repair protein; |
72-353 |
1.04e-24 |
|
multifunctional CCA addition/repair protein;
Pssm-ID: 182810 [Multi-domain] Cd Length: 409 Bit Score: 106.09 E-value: 1.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 72 YIVGGAVRDLILGHRPKDFD-VATNATPEQVKAlfrrafiigRRFRIVhvvygrGREhevievstFRAYLDPNAAEQ--V 148
Cdd:PRK10885 4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEMLA---------QGYQQV------GKD--------FPVFLHPKTHEEyaL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 149 AGNEKTSKRelADKSHVVDASGRV-LrdnvwgpqDQDAARRDFTVNAMYYDPHtGVVVDYHGGIKDAKKRVLRMIGdPAt 227
Cdd:PRK10885 61 ARTERKSGR--GYTGFTCYAAPDVtL--------EEDLIRRDLTINAMAQDDD-GELIDPYGGQRDLEARLLRHVS-PA- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 228 rYREDPVRIIRVVRFAAK---LGFDIDPRTREPIREMAAL--LENVPQSRLFDEMVKLLQTGHAQASLAELRKQGLDRGV 302
Cdd:PRK10885 128 -FAEDPLRVLRVARFAARfahLGFRIAPETLALMREMVASgeLDALTPERVWKETERALMERNPQVFFQVLRDCGALAVL 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1803102895 303 FPILDAVFDESRR---HPGRDRFV-QLALADTDRRVAEDKPVapsfLLACLLwHD 353
Cdd:PRK10885 207 LPEIDALFGVPQPakwHPEIDTGIhTLMVLDQAAKLSPSLDV----RFAALC-HD 256
|
|
| PolyA_pol_RNAbd |
pfam12627 |
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ... |
247-310 |
3.39e-20 |
|
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.
Pssm-ID: 463648 [Multi-domain] Cd Length: 64 Bit Score: 84.07 E-value: 3.39e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1803102895 247 GFDIDPRTREPIREMAALLENVPQSRLFDEMVKLLQTGHAQASLAELRKQGLDRGVFPILDAVF 310
Cdd:pfam12627 1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
|
|
| PRK13298 |
PRK13298 |
tRNA CCA-pyrophosphorylase; Provisional |
70-311 |
1.82e-19 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 237338 [Multi-domain] Cd Length: 417 Bit Score: 90.56 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 70 EAYIVGGAVRDLILGHRPKDFD-VATNATPEQvkalfrrafIIGRRFRIVhvvyGRGrehevievstFRAYLDPNAAEQV 148
Cdd:PRK13298 2 KIYLVGGAVRDSLLNLPVKDKDwVVVGGTPKI---------LLSINFQQV----GKD----------FPVFLHPETHEEY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 149 AGNEKTSKRELADKSHVVDASGRVlrdnvwgPQDQDAARRDFTVNAMYYDPHtGVVVDYHGGIKDAKKRVLRMIgdpATR 228
Cdd:PRK13298 59 ALARTERKSGVGYTGFITDTSSDV-------TLEEDLIRRDLTINAIAQDEN-GNYIDPFQGKKDIQLRLLRHV---SES 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 229 YREDPVRIIRVVRFAAK---LGFDIDPRTREPIREMAAL--LENVPQSRLFDEMVKLLQTGHAQASLAELRKQGLDRGVF 303
Cdd:PRK13298 128 FIEDPLRVLRVARFAALlvhLGFKIAKETMILMCIMVKKheLLYLTPERIWNETEKALKTDNPHVYFQVLYECNALKFLF 207
|
....*...
gi 1803102895 304 PILDAVFD 311
Cdd:PRK13298 208 PEIDFLYE 215
|
|
| PRK13297 |
PRK13297 |
tRNA CCA-pyrophosphorylase; Provisional |
67-368 |
8.02e-19 |
|
tRNA CCA-pyrophosphorylase; Provisional
Pssm-ID: 139469 [Multi-domain] Cd Length: 364 Bit Score: 88.13 E-value: 8.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 67 AGYEAYIVGGAVRDLILGHRPKDFD-VATNATPEQVKalfRRAFI-IGRRFRIvhvvygrgrehevievstfraYLDPNA 144
Cdd:PRK13297 10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMA---RRGFIpVGGDFPV---------------------FLHPRT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 145 AEQ--VAGNEKTSKRELADKSHVVDASGRVlrdnvwgpqDQDAARRDFTVNAMYYDPHtGVVVDYHGGIKDAKKRVLRMI 222
Cdd:PRK13297 66 KEEyaLARTERKSGRGYKGFTFYTGADVTL---------EQDLQRRDLTVNAIARTPQ-GELVDPLDGVADVRARVLRHV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 223 GDPatrYREDPVRIIRVVRFAAKLG-FDIDPRTREPIREMAALLEN---VPQsRLFDEMVKLLQTGHAQASLAELRKQGL 298
Cdd:PRK13297 136 GEA---FAEDPVRILRLGRFAARFGdFSIAPETMQLCRRMVEAGEAdalVPE-RVWKEVSRGLMAQAPSRMLDVLARAGA 211
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 299 DRGVFPILdavfdesrrhpgrdRFVQLALADTDRRVAEDKPVAPSFLLACLLWHDVLAHWQRYQAQGEPA 368
Cdd:PRK13297 212 LARVMPEL--------------HDDAAVRAEIDRAAAAGLPLAGRYALLCRHTPERDALGRRLRAPVECM 267
|
|
| PRK13296 |
PRK13296 |
CCA tRNA nucleotidyltransferase; |
70-282 |
8.68e-15 |
|
CCA tRNA nucleotidyltransferase;
Pssm-ID: 106256 [Multi-domain] Cd Length: 360 Bit Score: 75.79 E-value: 8.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 70 EAYIVGGAVRDLILGHRPKDFD-VATNATPEQvkaLFRRAFIigrrfRIvhvvygrgrehevieVSTFRAYLDPNAAEQV 148
Cdd:PRK13296 2 KFYLVGGAVRDMLLGITPKDKDwVVVGATEDE---MLANGFI-----KI---------------AANFPVFIHPQTKQEY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1803102895 149 AgnEKTSKRELADKSHVVDASgrvLRDNVwgPQDQDAARRDFTVNAMYYDPHTGvVVDYHGGIKDAKKRVLRmigDPATR 228
Cdd:PRK13296 59 A--LARSEKKTASGYHGFEVN---FSKYI--TLEDDLKRRDLTINSIAIDQNNK-VIDPFNGQADLQNRILR---HTSIA 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1803102895 229 YREDPVRIIRVVRFAAKLG---FDIDPRTREPIREM--AALLENVPQSRLFDEMVKLLQ 282
Cdd:PRK13296 128 FIEDPLRVVRLARFKAQLSnfnFSIAQEMLALIKELvkTGELNHLTRERLHIEFVKALN 186
|
|
| |
