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Conserved domains on  [gi|18027388|gb|AAL55776|]
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unknown [Homo sapiens]

Protein Classification

sugar MFS transporter( domain architecture ID 1905563)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
87-239 1.71e-06

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18027388 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-239 1.71e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18027388 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 1.81e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:cd06174  32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18027388 167 TLPNMFGDLRSTFIAlMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174 112 LFPERERGRALGLLQ-AFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 8.93e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388    87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnalSVLIFIALALNGFG-GMCMTFTS 165
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGaGALFPAAL 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18027388   166 LTLPNMFGDL-RSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 108 ALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-239 1.71e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG-GMCMTFTS 165
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18027388 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI-KLIYDAGVSFIVVLVVWAgCSGLVFLNCFFNWPLePFPGPED 239
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLI-LAVLLLLLALLFLRS-KLPEIEE 191
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 1.81e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSL 166
Cdd:cd06174  32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18027388 167 TLPNMFGDLRSTFIAlMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174 112 LFPERERGRALGLLQ-AFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-227 8.03e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 8.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnaLSVLIFIALALnGFGGMCMTFTSLTLP 169
Cdd:COG2223  44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS----YWLLLLLGLLL-GIGGGGSFAVGIALV 118

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18027388 170 NMF--GDLRSTF--IALMIGSYASSAVTFPGIKLIYDAGVSfiVVLVVWAGCSGLVFLNCFF 227
Cdd:COG2223 119 SKWfpPDRRGLAlgLAAGGGNLGAAVAAFLAPLLIAAFGWR--NAFLILGILLLVVAVLAWL 178
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 8.93e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 8.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388    87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnalSVLIFIALALNGFG-GMCMTFTS 165
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGaGALFPAAL 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18027388   166 LTLPNMFGDL-RSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 108 ALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 90-195 1.01e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.57  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  90 LAFTVGsFLLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgASKPNALSVLIFIaLALNGFGGMCMTFTSLTL 168
Cdd:cd17355  42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLAL-ATSLWQLYLLWGL-LGGGGAGTLAAVAFATVA 118

                        90       100
                ....*....|....*....|....*..
gi 18027388 169 PNMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFL 145
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 98-167 1.59e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 1.59e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18027388  98 LLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgaSKPNALSVLIFIALALNGFgGMCMTFTSLT 167
Cdd:cd17503 225 LASAILSPLvGRLLDKFGPRLLLLAGLLLLALGTLLLAF--LTPDTSLWLIILPLFIRGL-GMGLVFMPLN 292
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
91-231 1.74e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  91 AFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnalSVLIFIALALNGFG-GMCMTFTSLTLP 169
Cdd:COG2271  53 AFFLGYALGQ---IPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS-----FWQLLLLRFLLGLGeAGFFPAALKLIA 124

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18027388 170 NMF-GDLRSTFIAL-MIGSYASSAVTFPGIKLIYDAG------VSFIVVLVVWAGCS--GLVFLNCFFNWPL 231
Cdd:COG2271 125 EWFpPKERGRALGIfNAGGPLGGALAPPLLGWLLAAFgwraafLILGLPGLLLALLRfwLLALAYFLVYFAL 196
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 90-160 2.69e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.37  E-value: 2.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18027388  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGaskpnalsvlIFIALALNGFGGMC 160
Cdd:cd17353  42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFA----------ISLPLLFLGYGVLG 102
MFS_1 pfam07690
Major Facilitator Superfamily;
90-195 4.16e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388    90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                          90       100
                  ....*....|....*....|....*.
gi 18027388   170 NMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 88-194 5.93e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 42.24  E-value: 5.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  88 LNLAFtVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKP-NALSV-LIFIALALNGFGGMCMTFTS 165
Cdd:cd17354  40 NNLLS-VAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTGLiSDLSFwLMCLCFFLIGNSTSSLYTAA 118

                        90       100       110
                ....*....|....*....|....*....|
gi 18027388 166 L-TLPNMFGDLRSTFIALMIGSYASSAVTF 194
Cdd:cd17354 119 LvTCAKNFPESRGLAIGIPKGCYGLSGAIG 148
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-187 1.07e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLP 169
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                        90
                ....*....|....*...
gi 18027388 170 nmfGDLRSTFIALMIGSY 187
Cdd:COG2814 327 ---PEARGRASGLYNSAF 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
87-230 1.23e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASkpnaLSVLIFIALALNGFGGMCMTFTSL 166
Cdd:COG2814  46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALA 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18027388 167 TLPNMF-GDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWP 230
Cdd:COG2814 122 LIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-185 1.35e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  87 MLNLAFTVGSFLLsaitlplGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIAlalngfgGMCMTFTSL 166
Cdd:cd17365 214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA-------GACVNGAQV 279

                        90       100
                ....*....|....*....|....
gi 18027388 167 TLPNMFGDL-----RSTFIALMIG 185
Cdd:cd17365 280 GLYALAARFyptevRATGVGWALG 303
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-223 1.77e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  92 FTVGSFLLSAIT--LPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPnalsvLIFIALALNGFG------------ 157
Cdd:cd17489  35 LVVGLFTLAALLarPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-----LLLVLRLIHGIGwgafttaaatlv 109

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18027388 158 -----------GMCMTFTSLTLPNMFGdlrstfiaLMIGSYASSAVTFPGIkliydagvsFIVVLVVWAGCSGLVFL 223
Cdd:cd17489 110 adiippsrrgeGIGYYGLATTLAMALG--------PALGLFLYQHLGFAVL---------FIVAAVLALLALLLVFL 169
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
82-175 2.39e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 2.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  82 QAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgaSKPNALsVLIFIALALNGFGgmcM 161
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF--LGPGNL-WLLLVLAALAGIG---L 333

                        90
                ....*....|....
gi 18027388 162 TFTSLTLPNMFGDL 175
Cdd:COG2211 334 GAILVLPWAMLADV 347
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 90-167 2.43e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18027388  90 LAFTVGSFLLSAITlplGIVMDKYGPRKLRLLGSACFAVSCLLIAYGAskPNALSVLIFIALALNGFgGMCMTFTSLT 167
Cdd:cd17321 211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLG--ADSSVWLLLPGLVLLGL-GLGLFATPLT 282
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
90-223 3.13e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 3.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  90 LAFTVGSFLLsaitlplGIVMDKYGPRKLrLLGSACFAVSCLLIAYGASKPnALSVLIFIALALnGFGGMCMTFTSLTLp 169
Cdd:COG0738 257 GGMTIGRFLG-------GFLLKRFGPVRL-LRLSALLAAVGLLLALLAPGP-WLALIGLALVGL-GLSLMFPTIFSLAL- 325

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18027388 170 NMFGDLRSTFIA-LMIGSYASSAVTFPGIKLIYDAgVSFIVVLVVWAGCSGLVFL 223
Cdd:COG0738 326 DGLGKRTAAAVSaVLIMGIVGGAIGPPLIGFLADA-FGLRAAFLVPLVCYLLILL 379
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 91-168 4.78e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.78e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18027388  91 AFTVGSFLLsaiTLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIalalngFGGMCMTFTSLTL 168
Cdd:cd17477 231 AFVLGGLLL---QWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL------WGGAAGPLYTLAL 299
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 88-223 5.80e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.76  E-value: 5.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  88 LNLAFTVGSFLLSAI-------TLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIalalnGFGGMC 160
Cdd:cd17475  26 LHLSLAQVGLLLSALnlgvavsMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV-----GAGYGS 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18027388 161 MTFTSLTL------PNMFG---DLRSTFIALmigSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFL 223
Cdd:cd17475 101 VQPGGGRAimrwfpPRERGlamGIRQTGVPL---GGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL 169
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 88-175 7.37e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.74  E-value: 7.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18027388  88 LNLAFTVGSFLLSAItLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGaskPNALSVLIFIALALNGFGgmcMTFTSLT 167
Cdd:cd17332 259 VLLLLLILSGALLAL-LPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFL---PPGNLVLILVLAVLAGIG---YGGANLL 331


                ....*...
gi 18027388 168 LPNMFGDL 175
Cdd:cd17332 332 PWAMLADV 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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