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Conserved domains on  [gi|1802446886|ref|NP_001364992|]
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tetratricopeptide repeat protein 12 isoform 5 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
80-207 1.06e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  80 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 159
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886 160 LALKNYS---VNWRR---LNKNVKCTLCSYACLLHW--EQEESRECYKKILEINPK 207
Cdd:COG0457    87 QALGRYEealEDYDKaleLDPDDAEALYNLGLALLElgRYDEAIEAYERALELDPD 142
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
80-207 1.06e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  80 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 159
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886 160 LALKNYS---VNWRR---LNKNVKCTLCSYACLLHW--EQEESRECYKKILEINPK 207
Cdd:COG0457    87 QALGRYEealEDYDKaleLDPDDAEALYNLGLALLElgRYDEAIEAYERALELDPD 142
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 25-167 2.16e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.77  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  25 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 104
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886 105 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTK-------AYFHMGKANLALKNYSV 167
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTA 219
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 80-166 1.29e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.49  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  80 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 159
Cdd:PLN03088    1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80


                  ....*..
gi 1802446886 160 LALKNYS 166
Cdd:PLN03088   81 MKLEEYQ 87
TPR_1 pfam00515
Tetratricopeptide repeat;
118-148 2.73e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 2.73e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1802446886 118 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 148
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 118-148 3.49e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1802446886  118 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 148
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 81-139 7.11e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 7.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886  81 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 139
Cdd:cd15830     3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
80-207 1.06e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  80 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 159
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886 160 LALKNYS---VNWRR---LNKNVKCTLCSYACLLHW--EQEESRECYKKILEINPK 207
Cdd:COG0457    87 QALGRYEealEDYDKaleLDPDDAEALYNLGLALLElgRYDEAIEAYERALELDPD 142
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 25-167 2.16e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.77  E-value: 2.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  25 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 104
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886 105 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTK-------AYFHMGKANLALKNYSV 167
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTA 219
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 80-166 1.29e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.49  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  80 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKAN 159
Cdd:PLN03088    1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80


                  ....*..
gi 1802446886 160 LALKNYS 166
Cdd:PLN03088   81 MKLEEYQ 87
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
81-237 4.02e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 4.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  81 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 160
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802446886 161 ALKNYSVNWRRLNKNVKCTLCSYACLLHWEQEESRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLD 237
Cdd:COG0457   156 KLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 67-172 6.94e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 6.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  67 AKERAKRRRENkvlADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDE 146
Cdd:COG4235     6 LRQALAANPND---AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                          90       100
                  ....*....|....*....|....*....
gi 1802446886 147 KCTKAYFHMGKANLALKNYS---VNWRRL 172
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAeaiAAWQKL 111
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
51-165 1.23e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  51 AEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 130
Cdd:COG4785    43 DLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD 122

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1802446886 131 YEKALVDCEWALKCDEKCTKAYFHMGKANLALKNY 165
Cdd:COG4785   123 YDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 81-207 1.35e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  81 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 160
Cdd:COG3914   112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1802446886 161 ALKNYsvnwrrlnknvkctlcsyacllhweqEESRECYKKILEINPK 207
Cdd:COG3914   192 DLGRL--------------------------EEAIAAYRRALELDPD 212
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 57-165 5.72e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.88  E-value: 5.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  57 EAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALV 136
Cdd:COG5010    30 ALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKE 109

                          90       100
                  ....*....|....*....|....*....
gi 1802446886 137 DCEWALKCDEKCTKAYFHMGKANLALKNY 165
Cdd:COG5010   110 YYEKALALSPDNPNAYSNLAALLLSLGQD 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 81-165 7.09e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 7.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  81 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 160
Cdd:COG4783    38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117


                  ....*
gi 1802446886 161 ALKNY 165
Cdd:COG4783   118 ALGRP 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 81-165 1.96e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  81 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 160
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83


                  ....*
gi 1802446886 161 ALKNY 165
Cdd:COG4783    84 KAGDY 88
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 81-238 2.15e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  81 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANL 160
Cdd:COG2956   110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1802446886 161 ALKNYsvnwrrlnknvkctlcsyacllhweqEESRECYKKILEINPKlqtQVKGYLNQVDLQEKADlQEKEAHELLDS 238
Cdd:COG2956   190 EQGDY--------------------------EEAIAALERALEQDPD---YLPALPRLAELYEKLG-DPEEALELLRK 237
TPR_1 pfam00515
Tetratricopeptide repeat;
118-148 2.73e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 2.73e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1802446886 118 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 148
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 118-148 3.49e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 41.28  E-value: 3.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1802446886  118 YTNRAQAYMKLEDYEKALVDCEWALKCDEKC 148
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
46-165 5.02e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  46 TAMKSAEEINSEAFLASVEKDAKERAKRRRENKVL----ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYtNR 121
Cdd:COG4785     1 LYALALALLLALALAAAAASKAAILLAALLFAAVLalaiALADLALALAAAALAAAALAAERIDRALALPDLAQLYY-ER 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1802446886 122 AQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNY 165
Cdd:COG4785    80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDY 123
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
91-209 9.82e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  91 AFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALvDCEWALKCDEKCTKAYFHMGKANLALKNYsvnwr 170
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDY----- 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1802446886 171 rlnknvkctlcsyacllhweqEESRECYKKILEINPKLQ 209
Cdd:COG3063    76 ---------------------DEALAYLERALELDPSAL 93
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
65-135 2.37e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 40.25  E-value: 2.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886  65 KDAKERAKRRR--ENKV-LADALkekgneaFAEGNYETAILRYSEGLEKL--KDMKVLYtNRAQAYMKLEDYEKAL 135
Cdd:COG4700    77 RELEKALEFADtvQNRVrLADAL-------LELGRYDEAIELYEEALTGIfaDDPHILL-GLAQALFELGRYAEAL 144
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 23-166 4.20e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.35  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  23 MEEDQEEDEcrttlnKTMISPPQTAMKSAEEINSEAFlasvEKDAKERAKRRRENKV---LADALKEKGNEAFAEGNYET 99
Cdd:TIGR00990 280 LEDSNELDE------ETGNGQLQLGLKSPESKADESY----EEAARAFEKALDLGKLgekEAIALNLRGTFKCLKGKHLE 349

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802446886 100 AILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYS 166
Cdd:TIGR00990 350 ALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFA 416
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
81-143 5.53e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 5.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802446886  81 ADALKEKGNEAFAEGNYETAIlRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 143
Cdd:COG3063    26 ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 81-139 7.11e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 7.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802446886  81 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 139
Cdd:cd15830     3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 51-237 9.39e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886  51 AEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 130
Cdd:COG3914    14 AAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446886 131 YEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYsvnwrrlnknvkctlcsyacllhweqEESRECYKKILEINPKLqt 210
Cdd:COG3914    94 YEEALALYRRALALNPDNAEALFNLGNLLLALGRL--------------------------EEALAALRRALALNPDF-- 145

                         170       180
                  ....*....|....*....|....*..
gi 1802446886 211 qVKGYLNQVDLQEKADlQEKEAHELLD 237
Cdd:COG3914   146 -AEAYLNLGEALRRLG-RLEEAIAALR 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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