NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1802446884|ref|NP_001364990|]
View 

solute carrier family 49 member A3 isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
28-363 8.23e-131

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17399:

Pssm-ID: 475125  Cd Length: 419  Bit Score: 385.08  E-value: 8.23e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  99 --------------------------RTLWASLWP--MCCPL----CW---SRR-------------------------- 117
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgQTLAAFAQPfiLFLPTklaaLWfpdNQRaianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 118 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 188
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 189 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 268
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 269 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 343
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446884 344 SLLLMAGLCTFFSCILAVFF 363
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
PHA03381 super family cl31824
tegument protein VP22; Provisional
373-478 1.27e-04

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 373 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 448
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446884 449 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 478
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
28-363 8.23e-131

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 385.08  E-value: 8.23e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  99 --------------------------RTLWASLWP--MCCPL----CW---SRR-------------------------- 117
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgQTLAAFAQPfiLFLPTklaaLWfpdNQRaianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 118 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 188
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 189 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 268
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 269 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 343
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446884 344 SLLLMAGLCTFFSCILAVFF 363
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
125-308 6.37e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 125 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWnkAYVILAVCLGGMIGISASFSALLEQILcasGHSSGF 204
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASA 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 205 SGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAME 284
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQA 319
                         170       180
                  ....*....|....*....|....
gi 1802446884 285 LAVECSFPVGEGAATGMIFVLGQA 308
Cdd:COG2814   320 LVAELAPPEARGRASGLYNSAFFL 343
PHA03381 PHA03381
tegument protein VP22; Provisional
373-478 1.27e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 373 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 448
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446884 449 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 478
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
28-363 8.23e-131

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 385.08  E-value: 8.23e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAA--------- 98
Cdd:cd17399     1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAiilgawlnf 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  99 --------------------------RTLWASLWP--MCCPL----CW---SRR-------------------------- 117
Cdd:cd17399    81 igavirvisslpfvdpsfrfpvlmtgQTLAAFAQPfiLFLPTklaaLWfpdNQRaianmlasmsnplgvllanllspliv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 118 ---------LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFS 188
Cdd:cd17399   161 kssedifllLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 189 ALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 268
Cdd:cd17399   240 TLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLC 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 269 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTV 343
Cdd:cd17399   320 GLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTV 399
                         410       420
                  ....*....|....*....|
gi 1802446884 344 SLLLMAGLCTFFSCILAVFF 363
Cdd:cd17399   400 PLLVMAGLAAVLAIIFVVFF 419
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
28-363 7.03e-98

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 300.47  E-value: 7.03e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAARTLWASL-- 105
Cdd:cd17334     1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALna 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 106 ---WPMCCPLCW-------------------------------------------------------------------- 114
Cdd:cd17334    81 lgsVLKCIPLGQqpkfallvlgqvlnalaqvlvlslppliaavwfppkerttataiaslanflgcaigfllppvvvpppk 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 115 ---SRRLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEK-------FLDGLKLLMWNKAYVILAVCLGGMIGIS 184
Cdd:cd17334   161 gtkKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNsehvileLQKSISELLRNEPFVLLAVAFSIMMGVF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 185 ASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQGQT 261
Cdd:cd17334   241 AGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVT 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 262 LALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedPLDW 341
Cdd:cd17334   321 LAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------PTPT 385
                         410       420
                  ....*....|....*....|..
gi 1802446884 342 TVSLLLMAGLCTFFSCILAVFF 363
Cdd:cd17334   386 ESKYLLWFILCTVGSCLGALFF 407
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
28-320 1.24e-28

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 116.95  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAARTLWASL-- 105
Cdd:cd17398     1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLnc 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 106 ---WPMC-----------------CPLCWSRRLGV--------------------------------------------- 120
Cdd:cd17398    81 lgaWLKLfssspdlfwvamagqtiCALAQVFILGIpprlaavwfgpdevstataigvfgnqlgvalgfvlppllvpnsen 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 121 -----------YTIPAGV--VCLLSTICLWESVPPTPPSAGAASSTSEK-----FLDGLKLLMWNKAYVILAVCLGGMIG 182
Cdd:cd17398   161 kdeigkglsilFYGVAGIctALFILVIIFFKEKPPIPPSRAQAAAQELRsedqsYLGSLKRLFKNKGFLLLLITYGINTG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 183 ISASFSALLEQ-ILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLQGQT 261
Cdd:cd17398   241 VYYAISTLLNQmVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSI 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1802446884 262 LALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTAL 320
Cdd:cd17398   320 WVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
28-318 1.56e-17

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 84.27  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAE-------DLVLSMeqiNWLSLVYLVVSTPFgvaaIWILDSVGLRAART 100
Cdd:cd17397     1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPafgwsdsDIALLA---NWGPIGFVPTFFFM----AWLMDVKGLRIAVL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 101 LWASLWPMCCPL-CWSRRLGV--YTIPAG--------------------------------------------------- 126
Cdd:cd17397    74 SSAFLVAAGTGLrCIPVPNHLatWLIHIGqflnglagpvamaaapflsatwfppnqratataiasifnylggaasfligp 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 127 -----------VVCLLSTICLWESVPPTPPSAgAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQIL 195
Cdd:cd17397   154 lvlmylefgwsALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 196 CASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEatKIGLCLFSLACVPFALVSQLQ-----GQTLALAATCSL 270
Cdd:cd17397   233 TPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTSCIL 310
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1802446884 271 LGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMT 318
Cdd:cd17397   311 LGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
28-321 1.70e-16

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 81.41  E-value: 1.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAARTLWASL-- 105
Cdd:cd17455     1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLnc 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 106 ---WPMCCP----LCW--------------------SRRLGVYTIPAGV------------------------------- 127
Cdd:cd17455    81 lgaWVKCASvrpdLFGvtmlaqvlcsvaqvfilglpSRIASVWFGPREVstacavavlgnqlgtaigfllppvlvpntvd 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 128 ---------------------VCLLSTICLWESVPPTPPSAGAA-----SSTSEKFLDGLKLLMWNKAYVILAVCLGGMI 181
Cdd:cd17455   161 didlmghnisimfygtaavstLLFILTIIVFKEKPPLPPSQAQAvlqgiPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 182 GISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLq 258
Cdd:cd17455   241 GTFYSVSTLLNQMIIT--HYEGeevNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL- 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802446884 259 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT 321
Cdd:cd17455   318 GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
28-316 2.84e-13

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 71.35  E-value: 2.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLR----AARTL-- 101
Cdd:cd17456     1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRvialVGSALnc 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 102 ---W-----------------------------------ASLW-------PMCCPLCWSRRLGV---------------- 120
Cdd:cd17456    81 lgaWiktgsarpdlfpvtvlgqlvcsvaqvfilgmpsriASVWfgssevsTACSIGVFGNQLGVaigfllppvlvpnidd 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 121 -----------YTIPAGVVCLLS--TICLWESVPPTPPS---AGAASSTSEK--FLDGLKLLMWNKAYVILAVCLGGMIG 182
Cdd:cd17456   161 ldelayhisimFYGTAAVATLLFilVIIVFQEKPKIPPSqaqAAIQSIPSQDysYLQSILRLLKNVNFILLVVSYGLNTG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 183 ISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFALVSQLq 258
Cdd:cd17456   241 CFYALSTLLNRMVIF--HYPGeevNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYTFTLNL- 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1802446884 259 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLA 316
Cdd:cd17456   317 GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTIS 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
125-308 6.37e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 125 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLLMWnkAYVILAVCLGGMIGISASFSALLEQILcasGHSSGF 204
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASA 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 205 SGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAME 284
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQA 319
                         170       180
                  ....*....|....*....|....
gi 1802446884 285 LAVECSFPVGEGAATGMIFVLGQA 308
Cdd:COG2814   320 LVAELAPPEARGRASGLYNSAFFL 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
125-323 9.81e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 9.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 125 AGVVCLLSTICLWESVPPTP--PSAGAASSTSEKFLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSS 202
Cdd:cd06174   158 AAALALLAAILLLLVVPDPPesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 203 G-FSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLGLFGFSVGPV 281
Cdd:cd06174   238 VaVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPL 313
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1802446884 282 AMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVR 323
Cdd:cd06174   314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
27-306 2.73e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.40  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884  27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRaaRTLWASLW 106
Cdd:COG2807    14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE--RTLLLALL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 107 PMCCPLC-----------------------------------------------------------------------WS 115
Cdd:COG2807    92 LLAAGLLlrslapsvalllagtaligagiavgnvllpglikrwfpdrvglmtglytaamglgaalaagltvplaaalgWR 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 116 RRLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSekfldglklLMWNKAYVILAVCLGGMIGISASFSALLEQIL 195
Cdd:COG2807   172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS---------LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 196 CASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHfteatKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFG 275
Cdd:COG2807   243 RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQ 317
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1802446884 276 FSVGPVAMELAVECSFPVGE-GAATGMIFVLG 306
Cdd:COG2807   318 GGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
PHA03381 PHA03381
tegument protein VP22; Provisional
373-478 1.27e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 43.85  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 373 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 448
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
                          90       100       110
                  ....*....|....*....|....*....|
gi 1802446884 449 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 478
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
125-320 1.29e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 125 AGVVCLLSTICLWESVPPTPPSAGAASSTSEK-FLDGLKLLMWNKAYVILAVCLGGMIGISASFSALLEQILcasGHSSG 203
Cdd:COG2223   165 LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRdQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF---GLSAA 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 204 FSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLF-GFSVGPVA 282
Cdd:COG2223   242 TAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAVF 317
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1802446884 283 MELAVecSFPVGE-GAATGMIFVLGQAEGILIMLAMTAL 320
Cdd:COG2223   318 ALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
169-369 2.58e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 169 AYVILAVCLGGMIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRtkhFTEATKIGLCLFSLAC 248
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLA 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 249 VPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTvrrseps 328
Cdd:COG2271   259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL------- 331
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1802446884 329 lstcqqgeDPLDWTVSLLLMAGLCtFFSCILAVFFHTPYRR 369
Cdd:COG2271   332 --------DATGYQAAFLLLAALA-LLAALLALLLLRETRK 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
120-283 3.04e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 120 VYTIPAGVVCLLSTICLWESVPPTPPSAGaasstsekFLDGLKLLMWNKAYVIL-AVCLGGMIGISASFSALLEQILCAS 198
Cdd:COG2211   188 IFAVLGLLAFLLTFFGTKERPVPEEEKVS--------LKESLKALLKNRPFLLLlLAYLLFFLALALVAALLLYYFKYVL 259
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 199 GHSSGFSGLCGALFITFGILGALALGPYVDRT-KHFTeaTKIGLCLFSLACVPFALVSqlQGQTLALAATCSLLGLF--G 275
Cdd:COG2211   260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVLAALAGIGlgA 335

                  ....*...
gi 1802446884 276 FSVGPVAM 283
Cdd:COG2211   336 ILVLPWAM 343
MATE_rft1 cd13130
Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This ...
242-367 6.45e-03

Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This eukaryotic family may function as a transporter, shuttling phospholipids, lipopolysaccharides or oligosaccharides from cytoplasmic to the lumenal side of the endoplasmic reticulum. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance.


Pssm-ID: 240535  Cd Length: 441  Bit Score: 38.86  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802446884 242 CLFSLACVPFALVSQ--------LQGQTLALAATCslLGLFGFSVGPVAMELAVecsfpvgegaatgMIFVLGQ-AEGIL 312
Cdd:cd13130   131 CILELLSEPLYILSQnllkfrlrAIVETAATLVRC--LTTFILIVLGTGKEPKV-------------LVFALGQlAYGVC 195
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1802446884 313 IMLAM--TALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSC----------ILAVFFHTPY 367
Cdd:cd13130   196 LFFGYwyYFLQCFVSKKSSLFPLRNSNLMFFDKPTLRMCGLFTIQSFfkhlltegdkIVLVWFDTPY 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH