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Conserved domains on  [gi|1802444523]
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Chain A, Cytokine receptor common subunit beta

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 109-209 2.27e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802444523 109 PPEPRDLQIS-TDQDHFLLTWSvalgsPQSHWLSPGDlEFEVVYKRLQDS-WEDAAILLSNTSQATLgpEHLMPSSTYVA 186
Cdd:cd00063     1 PSPPTNLRVTdVTSTSVTLSWT-----PPEDDGGPIT-GYVVEYREKGSGdWKEVEVTPGSETSYTL--TGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|...
gi 1802444523 187 RVRTRLAPGsrlsgrPSKWSPEV 209
Cdd:cd00063    73 RVRAVNGGG------ESPPSESV 89
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 109-209 2.27e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802444523 109 PPEPRDLQIS-TDQDHFLLTWSvalgsPQSHWLSPGDlEFEVVYKRLQDS-WEDAAILLSNTSQATLgpEHLMPSSTYVA 186
Cdd:cd00063     1 PSPPTNLRVTdVTSTSVTLSWT-----PPEDDGGPIT-GYVVEYREKGSGdWKEVEVTPGSETSYTL--TGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|...
gi 1802444523 187 RVRTRLAPGsrlsgrPSKWSPEV 209
Cdd:cd00063    73 RVRAVNGGG------ESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 109-196 6.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 6.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802444523  109 PPEPRDLQIS-TDQDHFLLTWSVALGSPQSHWLspgdLEFEVVYKRLQDSWEDAAILLSNTSqATLgpEHLMPSSTYVAR 187
Cdd:smart00060   1 PSPPSNLRVTdVTSTSVTLSWEPPPDDGITGYI----VGYRVEYREEGSEWKEVNVTPSSTS-YTL--TGLKPGTEYEFR 73


                   ....*....
gi 1802444523  188 VRTRLAPGS 196
Cdd:smart00060  74 VRAVNGAGE 82
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 109-209 2.27e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802444523 109 PPEPRDLQIS-TDQDHFLLTWSvalgsPQSHWLSPGDlEFEVVYKRLQDS-WEDAAILLSNTSQATLgpEHLMPSSTYVA 186
Cdd:cd00063     1 PSPPTNLRVTdVTSTSVTLSWT-----PPEDDGGPIT-GYVVEYREKGSGdWKEVEVTPGSETSYTL--TGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|...
gi 1802444523 187 RVRTRLAPGsrlsgrPSKWSPEV 209
Cdd:cd00063    73 RVRAVNGGG------ESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 109-196 6.44e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 6.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802444523  109 PPEPRDLQIS-TDQDHFLLTWSVALGSPQSHWLspgdLEFEVVYKRLQDSWEDAAILLSNTSqATLgpEHLMPSSTYVAR 187
Cdd:smart00060   1 PSPPSNLRVTdVTSTSVTLSWEPPPDDGITGYI----VGYRVEYREEGSEWKEVNVTPSSTS-YTL--TGLKPGTEYEFR 73


                   ....*....
gi 1802444523  188 VRTRLAPGS 196
Cdd:smart00060  74 VRAVNGAGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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