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Conserved domains on  [gi|1801332849|ref|WP_160982723|]
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MarR family winged helix-turn-helix transcriptional regulator, partial [Deinococcus xianganensis]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-117 3.07e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.03  E-value: 3.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   5 HADLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDH 84
Cdd:COG1846    33 ELGLTPAQFRVLAALAEA---GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEA 109

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1801332849  85 LPVHLRREEELLSPLSAAERQQLEQLLRRLIAH 117
Cdd:COG1846   110 RPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-117 3.07e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.03  E-value: 3.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   5 HADLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDH 84
Cdd:COG1846    33 ELGLTPAQFRVLAALAEA---GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEA 109

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1801332849  85 LPVHLRREEELLSPLSAAERQQLEQLLRRLIAH 117
Cdd:COG1846   110 RPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
7-104 2.21e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.49  E-value: 2.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849    7 DLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDHLP 86
Cdd:smart00347   7 GLTPTQFLVLRILYEE---GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 1801332849   87 VHLRREEELLSPLSAAER 104
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 30-121 8.28e-12

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 58.61  E-value: 8.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849  30 PGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDHLPVHLRREEELLSPLSAAERQQLEQ 109
Cdd:PRK10870   74 PSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQ 153

                          90
                  ....*....|..
gi 1801332849 110 LLRRLIAHVETV 121
Cdd:PRK10870  154 ITRKLLSRLDQM 165
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-68 2.29e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 47.16  E-value: 2.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1801332849   8 LTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRA 68
Cdd:pfam01047   1 LTLTQFHILRILYEH---GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-117 3.07e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.03  E-value: 3.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   5 HADLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDH 84
Cdd:COG1846    33 ELGLTPAQFRVLAALAEA---GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEA 109

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1801332849  85 LPVHLRREEELLSPLSAAERQQLEQLLRRLIAH 117
Cdd:COG1846   110 RPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
7-104 2.21e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.49  E-value: 2.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849    7 DLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDHLP 86
Cdd:smart00347   7 GLTPTQFLVLRILYEE---GPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLE 83

                           90
                   ....*....|....*...
gi 1801332849   87 VHLRREEELLSPLSAAER 104
Cdd:smart00347  84 ARSETLAELLAGLTAEEQ 101
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 30-121 8.28e-12

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 58.61  E-value: 8.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849  30 PGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDHLPVHLRREEELLSPLSAAERQQLEQ 109
Cdd:PRK10870   74 PSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQ 153

                          90
                  ....*....|..
gi 1801332849 110 LLRRLIAHVETV 121
Cdd:PRK10870  154 ITRKLLSRLDQM 165
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 18-114 8.69e-10

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 52.70  E-value: 8.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849  18 TLYR-SSTPDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRDHLPVHLRREEELL 96
Cdd:PRK03573   36 TLHNiHQLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEIL 115

                          90
                  ....*....|....*...
gi 1801332849  97 SPLSAAERQQLEQLLRRL 114
Cdd:PRK03573  116 HGISAEEIEQLITLIAKL 133
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
6-80 1.03e-09

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 52.51  E-value: 1.03e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1801332849   6 ADLTAATRDLLFTLYRSSTPDG-LSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDaqdrraQRIHLTDAGRTL 80
Cdd:COG1321     2 MMLSESEEDYLKAIYELSEEGGpVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY------GGITLTEEGREL 71
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
7-115 2.07e-09

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 51.82  E-value: 2.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   7 DLTAATRDLLFTLyrsSTPDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAGRTLVRD-HL 85
Cdd:PRK11512   37 DITAAQFKVLCSI---RCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQcHQ 113

                          90       100       110
                  ....*....|....*....|....*....|
gi 1801332849  86 PVHLRREEELLSPLSAAERQQLEQLLRRLI 115
Cdd:PRK11512  114 LVGQDLHQELTKNLTADEVATLEHLLKKVL 143
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-68 2.29e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 47.16  E-value: 2.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1801332849   8 LTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRA 68
Cdd:pfam01047   1 LTLTQFHILRILYEH---GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-68 2.40e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.20  E-value: 2.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1801332849   7 DLTAATRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRA 68
Cdd:pfam12802   2 GLTPAQFRVLLALARN---PGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 30-97 3.70e-05

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 39.51  E-value: 3.70e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1801332849   30 PGELATLLAVSPASVTGSLDRLEMRGLLRRAPDaqdrraQRIHLTDAGRTLVRDHLPVHlRREEELLS 97
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPY------RGITLTEKGRRLARRLLRKH-RLLERFLV 61
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 12-62 6.33e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 35.43  E-value: 6.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1801332849  12 TRDLLFTLYR-SSTPDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPD 62
Cdd:pfam01325   3 TEDYLETIYTlSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPY 54
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 6-87 3.04e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 35.66  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   6 ADLTAATRDLLFTLYRSSTPDGLSP--GELATLLAVSPASVTGSLDRLEMRGLLRRAPDaqdrRAQRIHLTDAGRTLVRd 83
Cdd:COG1974     2 KKLTKRQREILDFIKEYIRERGYPPsqREIAEALGLSSSAVHRHLKALEKKGYLRRDPG----KSRAIELLPASPEVVG- 76


                  ....
gi 1801332849  84 hLPV 87
Cdd:COG1974    77 -LPL 79
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-75 3.81e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 35.24  E-value: 3.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1801332849  12 TRDLLFTLYRSstpDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPdaqDRRAQRIHLTD 75
Cdd:COG3398    99 PRRILLYLLEN---PGATNKELAEELGISRSTVSWHLKRLEEDGLVERER---DGRNVRYYLNP 156
HTH_27 pfam13463
Winged helix DNA-binding domain;
8-77 4.45e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 33.42  E-value: 4.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849   8 LTAATRDLLFTLYRSSTPDGLSpgELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRRAQRIHLTDAG 77
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLA--DICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
26-117 5.90e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 35.19  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1801332849  26 DGLSPGELATLLAVSPASVTGSLDRLEMRGLLRrapdAQDRRAQRIHLTDAGRTLVRDHLPvhlrrEEELLSPLSAAERQ 105
Cdd:PRK04172   19 KEATLEELAEKLGLPPEAVMRAAEWLEEKGLVK----VEERVEEVYVLTEEGKKYAEEGLP-----ERRLLNALKDGGEV 89

                          90
                  ....*....|..
gi 1801332849 106 QLEQLLRRLIAH 117
Cdd:PRK04172   90 SLDELKEALLDK 101
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
24-67 6.60e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 34.52  E-value: 6.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1801332849  24 TPDGLSPGELATLLAVSPASVTGSLDRLEMRGLLRRAPDAQDRR 67
Cdd:COG1510    39 SDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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