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Conserved domains on  [gi|1798335183|ref|WP_159550777|]
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MULTISPECIES: PAS domain S-box protein [Halomonadaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 151-506 2.65e-58

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 197.71  E-value: 2.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 151 RAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGE 230
Cdd:COG4191     1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 231 LEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAI 310
Cdd:COG4191    81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 311 ANYASGALMQLRTDPgrPASDLTLPLTRIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIA 390
Cdd:COG4191   161 LGNAELLRRRLEDEP--DPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 391 LEHELAEALPRVQADPIALEQVLVNLLLNALEASREQPGAtRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFHS 470
Cdd:COG4191   239 VELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGG-RITISTRREG-DYVVISVRDNGPGIPPEVLERIFEPFFT 316

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1798335183 471 SRP--EGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG4191   317 TKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGgGTTFT 355
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 43-146 1.29e-18

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


:

Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 81.14  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  43 TTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQQTYRFRAKDGHYVWFE 122
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|....
gi 1798335183 123 TTSRTRRDPAsGELIDVLCVSRDV 146
Cdd:cd00130    81 VSLTPIRDEG-GEVIGLLGVVRDI 103
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 151-506 2.65e-58

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 197.71  E-value: 2.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 151 RAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGE 230
Cdd:COG4191     1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 231 LEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAI 310
Cdd:COG4191    81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 311 ANYASGALMQLRTDPgrPASDLTLPLTRIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIA 390
Cdd:COG4191   161 LGNAELLRRRLEDEP--DPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 391 LEHELAEALPRVQADPIALEQVLVNLLLNALEASREQPGAtRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFHS 470
Cdd:COG4191   239 VELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGG-RITISTRREG-DYVVISVRDNGPGIPPEVLERIFEPFFT 316

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1798335183 471 SRP--EGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG4191   317 TKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGgGTTFT 355
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
122-506 1.37e-31

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 128.55  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 122 ETTSRTRRDPASGELidvlcvsRDVGRRIRAEANRERLAR-----VVESTTDYVLFCDGDERLFYSNEAARRLLGLPR-E 195
Cdd:PRK11360  229 ENDLSTRLPPLPGEL-------GEISQAINNLAQALRETRslnelILESIADGVIAIDRQGKITTMNPAAEVITGLQRhE 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 196 GLGARLEQAYTPGslTILREIVLPAVA-RYGSWSGELEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKaaea 274
Cdd:PRK11360  302 LVGKPYSELFPPN--TPFASPLLDTLEhGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERK---- 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 275 qarRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYasgalMQ-LRTDPGRPASDLTLPLtrIDEQVQRLAQRLRHI 353
Cdd:PRK11360  376 ---RLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY-----VQiWRQQTSDPPSQEYLSV--VLREVDRLNKVIDQL 445

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 354 RAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEAsreQPGATRV 433
Cdd:PRK11360  446 LEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQA---ISARGKI 522

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1798335183 434 EVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:PRK11360  523 RIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGvGTTFT 596
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-509 1.52e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 89.38  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 422 EASREQPGATR-VEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLE-LADG 499
Cdd:cd16920    14 EAMSEGGCERReLTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGRLSvESPA 93

                          90
                  ....*....|
gi 1798335183 500 SGGAIFTGTL 509
Cdd:cd16920    94 GGGATFQFTL 103
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 43-146 1.29e-18

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 81.14  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  43 TTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQQTYRFRAKDGHYVWFE 122
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|....
gi 1798335183 123 TTSRTRRDPAsGELIDVLCVSRDV 146
Cdd:cd00130    81 VSLTPIRDEG-GEVIGLLGVVRDI 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 428-506 4.92e-16

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 73.84  E-value: 4.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  428 PGATRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPF-----HSSRPEGLGMGLAISRSLMEAMGGSLELADGSG- 501
Cdd:smart00387  22 PEGGRITVTLERDG-DHVEITVEDNGPGIPPEDLEKIFEPFfrtdkRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGg 100


                   ....*
gi 1798335183  502 GAIFT 506
Cdd:smart00387 101 GTTFT 105
PAS COG2202
PAS domain [Signal transduction mechanisms];
28-156 1.86e-15

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 76.22  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  28 ELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVY-YHDGFYQ 106
Cdd:COG2202   131 ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLeGGRESYE 210

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1798335183 107 QTYRFRAKDGHYVWFETTSRTRRDpaSGELIDVLCVSRDVGRRIRAEANR 156
Cdd:COG2202   211 LELRLKDGDGRWVWVEASAVPLRD--GGEVIGVLGIVRDITERKRAEEAL 258
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 56-142 6.48e-15

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 70.06  E-value: 6.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  56 FLYASQAARDLLGYEPEELIG--VSAYDLFHPSDLADLLNKSPRVYYHDGFYQQTYRFRAKDGHYVWFETTSRTRRDPaS 133
Cdd:pfam08447   1 IIYWSPRFEEILGYTPEELLGkgESWLDLVHPDDRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDE-N 79


                  ....*....
gi 1798335183 134 GELIDVLCV 142
Cdd:pfam08447  80 GKPVRVIGV 88
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 423-509 7.87e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.47  E-value: 7.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 423 ASREQPGATRVEVHAHQSGprEVTFSVSDQGPGVTDDEAQAIFSPF---HSSRPEGLGMGLAISRSLMEAMGGSLELADG 499
Cdd:pfam02518  17 ALKHAAKAGEITVTLSEGG--ELTLTVEDNGIGIPPEDLPRIFEPFstaDKRGGGGTGLGLSIVRKLVELLGGTITVESE 94

                          90
                  ....*....|.
gi 1798335183 500 SG-GAIFTGTL 509
Cdd:pfam02518  95 PGgGTTVTLTL 105
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 34-156 4.59e-14

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 68.86  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  34 RHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPsdlaDLLNKSPRVYYHDGF-----YQQT 108
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPE----EDREEVRERIERRLEgepepVSEE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1798335183 109 YRFRAKDGHYVWFETTSRTRRdpASGELIDVLCVSRDVGRRIRAEANR 156
Cdd:TIGR00229  79 RRVRRKDGSEIWVEVSVSPIR--TNGGELGVVGIVRDITERKEAEEAL 124
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 39-92 6.97e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 60.88  E-value: 6.97e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1798335183   39 LAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLL 92
Cdd:smart00091   6 ILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQ 59
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 53-161 1.07e-06

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 51.60  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183   53 DGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHD-GFYQQTYRFRAKDGHYVWFETTSRTRRDP 131
Cdd:PRK09776   302 EGQWLQVNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLLSGEiNSYSMEKRYYRRDGEVVWALLAVSLVRDT 381

                           90       100       110
                   ....*....|....*....|....*....|
gi 1798335183  132 ASGELIDVLCVsRDVGRRIRAEANRERLAR 161
Cdd:PRK09776   382 DGTPLYFIAQI-EDINELKRTEQVNERLME 410
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 151-506 2.65e-58

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 197.71  E-value: 2.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 151 RAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGE 230
Cdd:COG4191     1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 231 LEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAI 310
Cdd:COG4191    81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 311 ANYASGALMQLRTDPgrPASDLTLPLTRIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIA 390
Cdd:COG4191   161 LGNAELLRRRLEDEP--DPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 391 LEHELAEALPRVQADPIALEQVLVNLLLNALEASREQPGAtRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFHS 470
Cdd:COG4191   239 VELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGG-RITISTRREG-DYVVISVRDNGPGIPPEVLERIFEPFFT 316

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1798335183 471 SRP--EGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG4191   317 TKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGgGTTFT 355
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 149-506 6.93e-48

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 171.30  E-value: 6.93e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 149 RIRAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLtiLREIVLPAVARYGSWS 228
Cdd:COG5000    82 REELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELD--LAELLREALERGWQEE 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 229 GELEMPGPQgavpvlsVVLAHRGPGAEPDHLSLLnRDIglrkaaeaqarrhqEQIAHANRLATTGELASNIAHELNQPLG 308
Cdd:COG5000   160 IELTRDGRR-------TLLVRASPLRDDGYVIVF-DDI--------------TELLRAERLAAWGELARRIAHEIKNPLT 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 309 AIANYASGALMQLRTDPGRPASDLTLPLTRIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAG 388
Cdd:COG5000   218 PIQLSAERLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKD 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 389 IALEHELAEALPRVQADPIALEQVLVNLLLNALEASREQPgatRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPF 468
Cdd:COG5000   298 IRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGG---EIEVSTRREDGR-VRIEVSDNGPGIPEEVLERIFEPF 373

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1798335183 469 HSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG5000   374 FTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGgGTTFT 412
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
151-506 9.44e-42

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 153.08  E-value: 9.44e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 151 RAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGL-GARLEQAYTPGSLtiLREIVLPAVARYGS-WS 228
Cdd:COG3852     1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELlGRPLAELFPEDSP--LRELLERALAEGQPvTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 229 GELEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGlrkaaeaQARRHQEQIAHANRLATTGELASNIAHELNQPLG 308
Cdd:COG3852    79 REVTLRRKDGEERPVDVSVSPLRDAEGEGGVLLVLRDIT-------ERKRLERELRRAEKLAAVGELAAGLAHEIRNPLT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 309 AIANYASGALMQLRTDPGRPASDLtlpltrIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQaG 388
Cdd:COG3852   152 GIRGAAQLLERELPDDELREYTQL------IIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPK-N 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 389 IALEHELAEALPRVQADPIALEQ---------VlvnlllnalEASREQP------GATRVEVHAHQSGPREVTFSVSDQG 453
Cdd:COG3852   225 IRIVRDYDPSLPEVLGDPDQLIQvllnlvrnaA---------EAMPEGGtitirtRVERQVTLGGLRPRLYVRIEVIDNG 295

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1798335183 454 PGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG3852   296 PGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGkGTTFR 349
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
275-506 3.99e-33

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 126.17  E-value: 3.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 275 QARRHQEQIAHANRLATtgELASNIAHELNQPLGAIANYASgalmQLRTDPGRPASDLTLPLTRIDEQVQRLAQRLRHIR 354
Cdd:COG2205     1 ELEEALEELEELERLKS--EFLANVSHELRTPLTSILGAAE----LLLDEEDLSPEERRELLEIIRESAERLLRLIEDLL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 355 AFVR----KGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASreqPGA 430
Cdd:COG2205    75 DLSRlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYS---PPG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 431 TRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFH----SSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIF 505
Cdd:COG2205   152 GTITISARREG-DGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGgGTTF 230


                  .
gi 1798335183 506 T 506
Cdd:COG2205   231 T 231
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
178-506 4.46e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 128.49  E-value: 4.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 178 RLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEMPGPQGAVPVLSVVLAHRGPGAEPD 257
Cdd:COG0642     8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 258 HLSLLNRDIGLRKAAEAQARRHQeqiahanrlattGELASNIAHELNQPLGAIANYASgaLMQLRTDPGRPASdltlpLT 337
Cdd:COG0642    88 LLLLLLLLLLALLLLLEEANEAK------------SRFLANVSHELRTPLTAIRGYLE--LLLEELDEEQREY-----LE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 338 RIDEQVQRLAQRLRHIRAFVR----KGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVL 413
Cdd:COG0642   149 TILRSADRLLRLINDLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 414 VNLLLNALEASREQpgaTRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFH----SSRPEGLGMGLAISRSLMEA 489
Cdd:COG0642   229 LNLLSNAIKYTPEG---GTVTVSVRREG-DRVRISVEDTGPGIPPEDLERIFEPFFrtdpSRRGGGTGLGLAIVKRIVEL 304

                         330
                  ....*....|....*...
gi 1798335183 490 MGGSLELADGSG-GAIFT 506
Cdd:COG0642   305 HGGTIEVESEPGkGTTFT 322
PAS COG2202
PAS domain [Signal transduction mechanisms];
27-275 1.29e-31

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 122.83  E-value: 1.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  27 LELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQ 106
Cdd:COG2202     4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 107 QTYRFRAKDGHYVWFETTSRTRRDpASGELIDVLCVSRDVGRRIRAEA----NRERLARVVESTTDYVLFCDGDERLFYS 182
Cdd:COG2202    84 GELRNRRKDGSLFWVELSISPVRD-EDGEITGFVGIARDITERKRAEEalreSEERLRLLVENAPDGIFVLDLDGRILYV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 183 NEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEM--PGPQGAVPVLSVVLAHRGPGAEPDHLS 260
Cdd:COG2202   163 NPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELrlKDGDGRWVWVEASAVPLRDGGEVIGVL 242

                         250
                  ....*....|....*
gi 1798335183 261 LLNRDIGLRKAAEAQ 275
Cdd:COG2202   243 GIVRDITERKRAEEA 257
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
122-506 1.37e-31

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 128.55  E-value: 1.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 122 ETTSRTRRDPASGELidvlcvsRDVGRRIRAEANRERLAR-----VVESTTDYVLFCDGDERLFYSNEAARRLLGLPR-E 195
Cdd:PRK11360  229 ENDLSTRLPPLPGEL-------GEISQAINNLAQALRETRslnelILESIADGVIAIDRQGKITTMNPAAEVITGLQRhE 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 196 GLGARLEQAYTPGslTILREIVLPAVA-RYGSWSGELEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKaaea 274
Cdd:PRK11360  302 LVGKPYSELFPPN--TPFASPLLDTLEhGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERK---- 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 275 qarRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYasgalMQ-LRTDPGRPASDLTLPLtrIDEQVQRLAQRLRHI 353
Cdd:PRK11360  376 ---RLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGY-----VQiWRQQTSDPPSQEYLSV--VLREVDRLNKVIDQL 445

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 354 RAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEAsreQPGATRV 433
Cdd:PRK11360  446 LEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQA---ISARGKI 522

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1798335183 434 EVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:PRK11360  523 RIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGvGTTFT 596
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 262-497 1.91e-30

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 125.57  E-value: 1.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 262 LNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYASGALMQLRtdpGRPASDLTLPLTRIDE 341
Cdd:COG4192   403 LETEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALE---QENYAQLPTSLDKIEG 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 342 QVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQY--QQAGIALEHElaealPRVQADPIALEQVLVNLLLN 419
Cdd:COG4192   480 LIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAkpQQITLHIPDD-----LMVQGDQVLLEQVLVNLLVN 554

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1798335183 420 ALEASREQPgatrvEVH-AHQSGPREVTFSVSDQGPGVTDdeAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELA 497
Cdd:COG4192   555 ALDAVATQP-----QISvDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLA 626
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 27-525 1.65e-29

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 121.23  E-value: 1.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  27 LELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQ 106
Cdd:COG5809     8 LQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGYTEDELLGTNILDFLHPDDEKELREILKLLKEGESRDE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 107 QTYRFRAKDGHYVWFETTSRTRRDpASGELIDVLCVSRDVGRRIRAEA----NRERLARVVESTTDYVLFCDGDERLFYS 182
Cdd:COG5809    88 LEFELRHKNGKRLEFSSKLSPIFD-QNGDIEGMLAISRDITERKRMEEalreSEEKFRLIFNHSPDGIIVTDLDGRIIYA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 183 NEAARRLLGLPRE-GLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEMPGPQGAVPVLSVVLAHRGPGAEPDHLSL 261
Cdd:COG5809   167 NPAACKLLGISIEeLIGKSILELIHSDDQENVAAFISQLLKDGGIAQGEVRFWTKDGRWRLLEASGAPIKKNGEVDGIVI 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 262 LNRDIGLRKaaeaqarRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYASgaLMQLRTD-PGRPASDLtlpltrID 340
Cdd:COG5809   247 IFRDITERK-------KLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQ--LLKDTIDeEQKTYLDI------ML 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 341 EQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNA 420
Cdd:COG5809   312 SELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNA 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 421 LEAsreQPGATRVEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELA-DG 499
Cdd:COG5809   392 IEA---MPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVEsEV 468

                         490       500
                  ....*....|....*....|....*.
gi 1798335183 500 SGGAIFTGTLlseanPIHRSVSPRSQ 525
Cdd:COG5809   469 GKGTTFSITL-----PIKLSEQVSMN 489
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 35-509 1.14e-24

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 107.12  E-value: 1.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  35 HYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVY--YHDGFYQQTYRfr 112
Cdd:COG5805    35 ELETILENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKTIFDFLEKEYHYRVKTRIERLQkgYDVVMIEQIYC-- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 113 aKDGHYVWFETTSRTRRDpaSGELIDVLCvSRDVGRRIRAEA----NRERLARVVESTTDYVLFCDGDERLFYSNEAARR 188
Cdd:COG5805   113 -KDGELIYVEVKLFPIYN--QNGQAAILA-LRDITKKKKIEEilqeQEERLQTLIENSPDLICVIDTDGRILFINESIER 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 189 LLGLPREGLGAR--LEQAYTPGSLTILREIVLPAvARYGSWSGELEMPGPQGAVPVLSVVLA--HRGPGAEPDHLSLLnR 264
Cdd:COG5805   189 LFGAPREELIGKnlLELLHPCDKEEFKERIESIT-EVWQEFIIEREIITKDGRIRYFEAVIVplIDTDGSVKGILVIL-R 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 265 DIGLRKAAEaqarrhqEQIAHANRLATTGELASNIAHELNQPLGAIANYASgaLMQLRTDPGRPASDLTLP-LTRIDEQV 343
Cdd:COG5805   267 DITEKKEAE-------ELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQ--LLQPGIEDKEEYFDIMLSeLDRIESII 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 344 QRLAqrlrhirAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEA 423
Cdd:COG5805   338 SEFL-------ALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEA 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 424 sreQPGATRVEVHAHQSGPrEVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-G 502
Cdd:COG5805   411 ---MPNGGTITIHTEEEDN-SVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGkG 486


                  ....*..
gi 1798335183 503 AIFTGTL 509
Cdd:COG5805   487 TTFTITL 493
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
148-509 9.85e-24

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 103.09  E-value: 9.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 148 RRIRAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSW 227
Cdd:COG5002    37 LLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 228 SGELEMPGPQGAVPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKAAEaQARRhqeqiahanrlattgELASNIAHELNQPL 307
Cdd:COG5002   117 LLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLE-QMRR---------------EFVANVSHELRTPL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 308 GAIANYASGALMQLRTDPgrpaSDLTLPLTRIDEQVQRLAQRLRHIRAFVR----KGQTRPRPVVLLDVVDAACRLCEWQ 383
Cdd:COG5002   181 TSIRGYLELLLDGAADDP----EERREYLEIILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 384 YQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASREQpgaTRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQA 463
Cdd:COG5002   257 AEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEG---GTITVSLREED-DQVRISVRDTGIGIPEEDLPR 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1798335183 464 IFSPFH------SSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFTGTL 509
Cdd:COG5002   333 IFERFYrvdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGkGTTFTITL 385
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
269-506 1.23e-23

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 103.71  E-value: 1.23e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 269 RKAAEAQaRRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYASgaLMQLRTDPGRPASDLTLPLTRideQVQRLAQ 348
Cdd:PRK10364  215 RRYLRSR-QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAK--YFAERAPAGGEAHQLAQVMAK---EADRLNR 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 349 RLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASREQp 428
Cdd:PRK10364  289 VVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH- 367

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1798335183 429 GATRVEVHAHQSGpreVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:PRK10364  368 GVISVTASESGAG---VKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGkGATFT 443
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-509 1.52e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 89.38  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 422 EASREQPGATR-VEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLE-LADG 499
Cdd:cd16920    14 EAMSEGGCERReLTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAHGGRLSvESPA 93

                          90
                  ....*....|
gi 1798335183 500 SGGAIFTGTL 509
Cdd:cd16920    94 GGGATFQFTL 103
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
273-492 5.70e-19

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 90.51  E-value: 5.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 273 EAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYASGALMQLRtdPGRPASDLTLPLTRIDEQVQRLAQRlrh 352
Cdd:PRK13837  431 ETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLA--RHSRAARYIDEIISAGARARLIIDQ--- 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 353 IRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQaGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASREqPGATR 432
Cdd:PRK13837  506 ILAFGRKGERNTKPFDLSELVTEIAPLLRVSLPP-GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDG-AGRVD 583

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1798335183 433 VEVHAHQ-SGPRE-----------VTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGG 492
Cdd:PRK13837  584 ISLSRAKlRAPKVlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAG 655
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 43-146 1.29e-18

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 81.14  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  43 TTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQQTYRFRAKDGHYVWFE 122
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|....
gi 1798335183 123 TTSRTRRDPAsGELIDVLCVSRDV 146
Cdd:cd00130    81 VSLTPIRDEG-GEVIGLLGVVRDI 103
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 12-509 7.01e-18

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 86.38  E-value: 7.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  12 LAELEARNAELEAKVLELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADL 91
Cdd:COG4251     1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  92 LNKSPRVYYHDGFYQQTYRFRAKDGHYVWFETTSRTRRDPASGELIDVLCVSRDVGRRIRAEANRERLARVVESTTDYVL 171
Cdd:COG4251    81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 172 FCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYG---SWSGELEMPGPQGAVPVLSVVLA 248
Cdd:COG4251   161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEaelLLSLGGGLGLLLLLLLLLVLLLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 249 HRGPGAEPDHLSLLNRDIGLRKAAEAQARRHQEQIAHANRlattgEL---ASNIAHELNQPLGAIANYASGALMQLRTDP 325
Cdd:COG4251   241 LILLLLLLILVLELLELRLELEELEEELEERTAELERSNE-----ELeqfAYVASHDLREPLRKISGFSQLLEEDYGDKL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 326 GRPASDLtlpLTRIDEQVQRLAQRLRHIRAFVR--KGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHElaeALPRVQ 403
Cdd:COG4251   316 DEEGREY---LERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG---PLPTVR 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 404 ADPIALEQVLVNLLLNALEASREQPGAtRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPF----HSSRPEGLGMG 479
Cdd:COG4251   390 GDPTLLRQVFQNLISNAIKYSRPGEPP-RIEIGAEREG-GEWVFSVRDNGIGIDPEYAEKIFEIFqrlhSRDEYEGTGIG 467

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1798335183 480 LAISRSLMEAMGGSLELADGSG-GAIFTGTL 509
Cdd:COG4251   468 LAIVKKIVERHGGRIWVESEPGeGATFYFTL 498
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 428-506 4.92e-16

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 73.84  E-value: 4.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  428 PGATRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPF-----HSSRPEGLGMGLAISRSLMEAMGGSLELADGSG- 501
Cdd:smart00387  22 PEGGRITVTLERDG-DHVEITVEDNGPGIPPEDLEKIFEPFfrtdkRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGg 100


                   ....*
gi 1798335183  502 GAIFT 506
Cdd:smart00387 101 GTTFT 105
PAS COG2202
PAS domain [Signal transduction mechanisms];
28-156 1.86e-15

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 76.22  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  28 ELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVY-YHDGFYQ 106
Cdd:COG2202   131 ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLeGGRESYE 210

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1798335183 107 QTYRFRAKDGHYVWFETTSRTRRDpaSGELIDVLCVSRDVGRRIRAEANR 156
Cdd:COG2202   211 LELRLKDGDGRWVWVEASAVPLRD--GGEVIGVLGIVRDITERKRAEEAL 258
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 56-142 6.48e-15

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 70.06  E-value: 6.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  56 FLYASQAARDLLGYEPEELIG--VSAYDLFHPSDLADLLNKSPRVYYHDGFYQQTYRFRAKDGHYVWFETTSRTRRDPaS 133
Cdd:pfam08447   1 IIYWSPRFEEILGYTPEELLGkgESWLDLVHPDDRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDE-N 79


                  ....*....
gi 1798335183 134 GELIDVLCV 142
Cdd:pfam08447  80 GKPVRVIGV 88
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 423-509 7.87e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.47  E-value: 7.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 423 ASREQPGATRVEVHAHQSGprEVTFSVSDQGPGVTDDEAQAIFSPF---HSSRPEGLGMGLAISRSLMEAMGGSLELADG 499
Cdd:pfam02518  17 ALKHAAKAGEITVTLSEGG--ELTLTVEDNGIGIPPEDLPRIFEPFstaDKRGGGGTGLGLSIVRKLVELLGGTITVESE 94

                          90
                  ....*....|.
gi 1798335183 500 SG-GAIFTGTL 509
Cdd:pfam02518  95 PGgGTTVTLTL 105
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 28-160 9.63e-15

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 76.69  E-value: 9.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  28 ELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNK--------SPRVY 99
Cdd:COG5805   151 ILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERiesitevwQEFII 230

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1798335183 100 yhdgfyqqTYRFRAKDGHYVWFETTSRTRRDPAsGELIDVLCVSRDVGRRIRAE---ANRERLA 160
Cdd:COG5805   231 --------EREIITKDGRIRYFEAVIVPLIDTD-GSVKGILVILRDITEKKEAEelmARSEKLS 285
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 34-156 4.59e-14

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 68.86  E-value: 4.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  34 RHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPsdlaDLLNKSPRVYYHDGF-----YQQT 108
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPE----EDREEVRERIERRLEgepepVSEE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1798335183 109 YRFRAKDGHYVWFETTSRTRRdpASGELIDVLCVSRDVGRRIRAEANR 156
Cdd:TIGR00229  79 RRVRRKDGSEIWVEVSVSPIR--TNGGELGVVGIVRDITERKEAEEAL 124
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-506 2.48e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 65.94  E-value: 2.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 423 ASREQPgatRVEVHAHQSGPREVtFSVSDQGPGVTDDEAQAIFSPFHSSRP--EGLGMGLAISRSLMEAMGGSLELAD-G 499
Cdd:cd16976    17 GKVENP---RIRIAARRLGGRLV-LVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGIVEEHGGRLSVANeE 92


                  ....*..
gi 1798335183 500 SGGAIFT 506
Cdd:cd16976    93 GAGARFT 99
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 432-509 2.69e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 65.98  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 432 RVEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFH------SSRPEGLGMGLAISRSLMEAMGGSLEL--ADGSgGA 503
Cdd:cd16922    24 RVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadsstTRKYGGTGLGLAISKKLVELMGGDISVesEPGQ-GS 102


                  ....*.
gi 1798335183 504 IFTGTL 509
Cdd:cd16922   103 TFTFTL 108
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 148-506 1.92e-12

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 68.72  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 148 RRIRAEANRERLArVVESTTDYVLFCDGDERLFYSNEAARRLLGLPREGLGArleqaytpgsltilrEIVLPAVARYGSW 227
Cdd:COG3290    76 LEEIARLVEEREA-VLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPI---------------DEVLAEVLETGER 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 228 SGELEMPGpqgavpvlSVVLAHRGPgaepdhLSLLNRDIGlrkaAEAQARRHQEQIAHANRLATTGELASNI---AHELN 304
Cdd:COG3290   140 DEEILLNG--------RVLVVNRVP------IRDDGRVVG----AVATFRDRTELERLEEELEGVKELAEALraqRHDFR 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 305 QPLGAIAnyasgALMQLrtdpGRPASDLTLpLTRIDEQVQRLAQRLRH------IRAFvrkgqtrprpvvLLDVVDAAcr 378
Cdd:COG3290   202 NHLHTIS-----GLLQL----GEYDEALEY-IDEISEELQELIDSLLSrignpvLAAL------------LLGKAARA-- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 379 lcewqyQQAGIALEHELAEALPRVQADPIALEQvlvnlllnaLEASREQPGATR-VEVHAHQSGpREVTFSVSDQGPGVT 457
Cdd:COG3290   258 ------RERGIDLTIDIDSDLPDLPLSDTDLVTilgnlldnaIEAVEKLPEEERrVELSIRDDG-DELVIEVEDSGPGIP 330

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1798335183 458 DDEAQAIFSPFHSSRP-EGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:COG3290   331 EELLEKIFERGFSTKLgEGRGLGLALVKQIVEKYGGTIEVESEEGeGTVFT 381
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 48-142 6.63e-12

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 62.31  E-value: 6.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  48 SRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQQT-YRFRAKDGHYVWFETTSR 126
Cdd:pfam14598   6 TRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGRATSPsYRLRLRDGDFLSVHTKSK 85

                          90
                  ....*....|....*.
gi 1798335183 127 TRRDPASGELIDVLCV 142
Cdd:pfam14598  86 LFLNQNSNQQPFIMCT 101
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 39-92 6.97e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 60.88  E-value: 6.97e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1798335183   39 LAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLL 92
Cdd:smart00091   6 ILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQ 59
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 34-146 7.91e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 62.05  E-value: 7.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  34 RHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQ-QTYRFR 112
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRgFEVSFR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1798335183 113 AKDGHYVWFETTSRTRRDPaSGELIDVLCVSRDV 146
Cdd:pfam00989  81 VPDGRPRHVEVRASPVRDA-GGEILGFLGVLRDI 113
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 53-146 8.88e-12

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 61.32  E-value: 8.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  53 DGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVyyHDGFYQQTYRFRAKDGHYVWFETTSRTRRDpA 132
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALRE--GKAVREFEVVLYRKDGEPFPVLVSLAPIRD-D 77

                          90
                  ....*....|....
gi 1798335183 133 SGELIDVLCVSRDV 146
Cdd:pfam13426  78 GGELVGIIAILRDI 91
PRK15347 PRK15347
two component system sensor kinase;
269-515 3.70e-11

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 65.82  E-value: 3.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 269 RKAAEAQARRHQEQiahANRLATtgELASNIAHELNQPLgaiaNYASGALMQLRTdpgrpasdltlplTRIDEQVQRLAQ 348
Cdd:PRK15347  380 RTQALAEAKQRAEQ---ANKRKS--EHLTTISHEIRTPL----NGVLGALELLQN-------------TPLTAEQMDLAD 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 349 RLRHIRA-----------FVR--KGQT--RPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQA-DPIALEQV 412
Cdd:PRK15347  438 TARQCTLsllaiinnlldFSRieSGQMtlSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHlDSLRLRQI 517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 413 LVNLLLNALEASREQPGATRVEVHAHQsgpreVTFSVSDQGPGVTDDEAQAIFSPFHSS--RPEGLGMGLAISRSLMEAM 490
Cdd:PRK15347  518 LVNLLGNAVKFTETGGIRLRVKRHEQQ-----LCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMM 592

                         250       260
                  ....*....|....*....|....*..
gi 1798335183 491 GGSLELADGSG-GAIFTGTL-LSEANP 515
Cdd:PRK15347  593 GGELTLFSTPGvGSCFSLVLpLNEYAP 619
PAS COG2202
PAS domain [Signal transduction mechanisms];
148-389 7.63e-11

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 62.73  E-value: 7.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 148 RRIRAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPR-EGLGARLEQAYTPGSLTILREIVLPAVARYGS 226
Cdd:COG2202     2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAeELLGKTLRDLLPPEDDDEFLELLRAALAGGGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 227 WSGELEMPGPQGA-VPVLSVVLAHRGPGAEPDHLSLLNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHEL-- 303
Cdd:COG2202    82 WRGELRNRRKDGSlFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRIly 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 304 -NQPLGAIANYASGALMqlrtdpGRPASDLTLPLTRiDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEW 382
Cdd:COG2202   162 vNPAAEELLGYSPEELL------GKSLLDLLHPEDR-ERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVPLRD 234


                  ....*..
gi 1798335183 383 QYQQAGI 389
Cdd:COG2202   235 GGEVIGV 241
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-506 9.15e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 58.84  E-value: 9.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 423 ASREQPGATRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEG-LGMGLAISRSLMEAMGGSLELADG-S 500
Cdd:cd16915    16 LAATGAPNKQVEVFLRDEG-DDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGeRGIGLALVRQSVERLGGSITVESEpG 94


                  ....*.
gi 1798335183 501 GGAIFT 506
Cdd:cd16915    95 GGTTFS 100
glnL PRK11073
nitrogen regulation protein NR(II);
273-506 9.84e-11

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 63.18  E-value: 9.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 273 EAQARRHQEQIAHANRLATTgELASNIAHELNQPLGAIANyASGALMQLRTDPGrpasdLTLPLTRIDEQVQRLaqrlrh 352
Cdd:PRK11073  112 DNQRRLSQEQLQHAQQVAAR-DLVRGLAHEIKNPLGGLRG-AAQLLSKALPDPA-----LTEYTKVIIEQADRL------ 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 353 iRAFVRK--GQTRPRPVV---LLDVVDAACRLCEWQyQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASREQ 427
Cdd:PRK11073  179 -RNLVDRllGPQRPGTHVtesIHKVAERVVQLVSLE-LPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQALGPE 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 428 PGA----TRVEVHAHQSGPR---EVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGS 500
Cdd:PRK11073  257 GGTitlrTRTAFQLTLHGERyrlAARIDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWP 336


                  ....*.
gi 1798335183 501 GGAIFT 506
Cdd:PRK11073  337 GHTEFS 342
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 300-509 2.70e-10

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 62.55  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 300 AHELNQPLGAIanyaSGALMQLRTDPgrPASDLTLPLTRIDEQVQRLAQ----RLRHIRAFVRKGQTRPRPVVLLDVVDA 375
Cdd:PRK11100  264 THELKSPLAAI----RGAAELLQEDP--PPEDRARFTGNILTQSARLQQlidrLLELARLEQRQELEVLEPVALAALLEE 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 376 ACRLCEWQYQQAGIALEHELAEAlpRVQADPIALEQVLVNLLLNALEASreqPGATRVEVHAHQSGpREVTFSVSDQGPG 455
Cdd:PRK11100  338 LVEAREAQAAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFS---PEGGTITLSAEVDG-EQVALSVEDQGPG 411

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 456 VTDDEAQAIFSPFHS-SRPEGL----GMGLAISRSLMEAMGGSLELADG-SGGAIFTGTL 509
Cdd:PRK11100  412 IPDYALPRIFERFYSlPRPANGrkstGLGLAFVREVARLHGGEVTLRNRpEGGVLATLTL 471
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-494 8.36e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 56.18  E-value: 8.36e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1798335183 423 ASREQPGatRVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFH------SSRPEGLGMGLAISRSLMEAMGGSL 494
Cdd:cd16949    12 ALRYSPS--KILLDISQDG-DQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERAIEQHGGKI 86
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 264-509 3.28e-09

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 59.57  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 264 RDIGLRKaaeaqarRHQEQIAHANRLATTgeLASNIAHELNQPLGAIANYASgalMQLRTdpgrpasdltlPLTriDEQV 343
Cdd:PRK11091  264 RDITERK-------RYQDALEKASRDKTT--FISTISHELRTPLNGIVGLSR---ILLDT-----------ELT--AEQR 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 344 QRLaqRLRHIRAFV----------------RKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPR-VQADP 406
Cdd:PRK11091  319 KYL--KTIHVSAITlgnifndiidmdkmerRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHkVITDG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 407 IALEQVLVNLLLNALEASREqpGATRVEVHAHQSgpREVTFSVSDQGPGVTDDEAQAIFSPF------HSSRPE-GLGMG 479
Cdd:PRK11091  397 TRLRQILWNLISNAVKFTQQ--GGVTVRVRYEEG--DMLTFEVEDSGIGIPEDELDKIFAMYyqvkdsHGGKPAtGTGIG 472

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1798335183 480 LAISRSLMEAMGGSLELADGSG-GAIFTGTL 509
Cdd:PRK11091  473 LAVSKRLAQAMGGDITVTSEEGkGSCFTLTI 503
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 429-504 5.50e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 53.61  E-value: 5.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 429 GATRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPF---HSSR-PEGLGMGLAISRSLMEAMGGSLELADGSGGAI 504
Cdd:cd16950    16 GGGWVEVSSDGEGNR-TRIQVLDNGPGIAPEEVDELFQPFyrgDNARgTSGTGLGLAIVQRISDAHGGSLTLANRAGGGL 94
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 428-494 7.71e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 53.35  E-value: 7.71e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1798335183 428 PGATRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGL------GMGLAISRSLMEAMGGSL 494
Cdd:cd16953    18 PDTGRITVSAMPTGKM-VTISVEDEGPGIPQEKLESIFDRFYTERPANEafgqhsGLGLSISRQIIEAHGGIS 89
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-505 1.34e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 52.79  E-value: 1.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1798335183 431 TRVEVHAHQSGPRE---VTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADGSGGAIF 505
Cdd:cd16918    27 TRTQRQVTLGHPRHrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLAIAQNIVSQHGGVIECDSQPGHTVF 104
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 364-522 1.55e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 57.61  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 364 PRPVVlldvvDAACRLCEWQYQQAGIALEHELAEALPR-VQADPIALEQVLVNLLLNALEASREqpGATRVEVHAHQSgp 442
Cdd:PRK11466  521 PRPLL-----ESTLQLMSGRVKGRPIRLATDIADDLPTaLMGDPRRIRQVITNLLSNALRFTDE--GSIVLRSRTDGE-- 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 443 rEVTFSVSDQGPGVTDDEAQAIFSPF--HSSRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFTGTLlseanPIHRS 519
Cdd:PRK11466  592 -QWLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEvGSCFCLRL-----PLRVA 665


                  ...
gi 1798335183 520 VSP 522
Cdd:PRK11466  666 TAP 668
PRK13557 PRK13557
histidine kinase; Provisional
 265-483 1.93e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 56.99  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 265 DIGLRKAAEaqarrhqEQIAHANRLATTGELASNIAHELNQPLGAIANYASgaLMQLRTDPGRP-ASDLTLPLTRIDEQV 343
Cdd:PRK13557  143 DVSRRRDAE-------DALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLD--VIQAALSHPDAdRGRMARSVENIRAAA 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 344 QRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAgIALEHELAEALPRVQADPIALEQVLVNLLLNALEA 423
Cdd:PRK13557  214 ERAATLTQQLLAFARKQRLEGRVLNLNGLVSGMGELAERTLGDA-VTIETDLAPDLWNCRIDPTQAEVALLNVLINARDA 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1798335183 424 SREQPGAT----RVEVHAHQSGP-------REVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAIS 483
Cdd:PRK13557  293 MPEGGRVTirtrNVEIEDEDLAMyhglppgRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLS 363
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 52-151 1.95e-08

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 52.42  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  52 RDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVyYHDGFYQQTYRFRAKDGHYVWFETTSRTRRDP 131
Cdd:pfam08448  13 PDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRA-LEGEEPIDFLEELLLNGEERHYELRLTPLRDP 91

                          90       100
                  ....*....|....*....|
gi 1798335183 132 aSGELIDVLCVSRDVGRRIR 151
Cdd:pfam08448  92 -DGEVIGVLVISRDITERRR 110
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 432-509 2.21e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 52.08  E-value: 2.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 432 RVEVHAHQSgPREVTFSVSDQGPGVTDDEAQAIFSPFH---SSRPE---GLGMGLAISRSLMEAMGGSLeLADGS--GGA 503
Cdd:cd16946    25 KLRIRAAQT-PQEVRLDVEDSAPGVSDDQLARLFERFYrveSSRNRasgGSGLGLAICHNIALAHGGTI-SAEHSplGGL 102


                  ....*.
gi 1798335183 504 IFTGTL 509
Cdd:cd16946   103 RLVLTL 108
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-504 3.21e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 51.77  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 422 EASREQPGATRVEVHAHQSGprEVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELADG-S 500
Cdd:cd16944    21 EGRPSDVGEVRIRVEADQDG--RIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEHGGRISLSNReA 98


                  ....
gi 1798335183 501 GGAI 504
Cdd:cd16944    99 GGAC 102
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 423-504 3.29e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 51.64  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 423 ASREQPGATRVEVHahQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRP---EGLGMGLAISRSLMEAMGGSLELADG 499
Cdd:cd16940    25 AVRYSPQGSRVEIK--LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGqnyGGSGLGLSIVKRIVELHGGQIFLGNA 102


                  ....*
gi 1798335183 500 SGGAI 504
Cdd:cd16940   103 QGGGL 107
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 426-506 3.85e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 51.27  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 426 EQPGATRVEVHAHQsgpREVTFSVSDQGPGVTDDEAQAIFSPFHSSRP--EGLGMGLAISRSLMEAMGGSLELADGSG-G 502
Cdd:cd16943    20 EGRGRITIRTWAHV---DQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGGTIRVASVPGgG 96


                  ....
gi 1798335183 503 AIFT 506
Cdd:cd16943    97 TRFT 100
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 432-509 4.67e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 51.17  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 432 RVEVHAhQSGPREVTFSVSDQGPGVTDDEAQAIFSPF---HS-SRPEGLGMGLAISRSLMEAMGGSLELADGSG-GAIFT 506
Cdd:cd16921    23 RIEVGA-EDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrlHSrEEYEGTGVGLAIVRKIIERHGGRIWLESEPGeGTTFY 101


                  ...
gi 1798335183 507 GTL 509
Cdd:cd16921   102 FTL 104
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 428-506 6.28e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 50.95  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 428 PGATRVEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPF------HSSRPEGLGMGLAISRSLMEAMGGSLELADGS- 500
Cdd:cd16925    21 PDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIVKEFVELHGGTVTVSDAPg 100


                  ....*.
gi 1798335183 501 GGAIFT 506
Cdd:cd16925   101 GGALFQ 106
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 24-169 4.82e-07

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 52.08  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  24 AKVLELDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVyyhdg 103
Cdd:COG3829     1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGKPV----- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1798335183 104 fYQQTYRFRAKDGHYVwfettsrTRRDP--ASGELIDVLCVSRDVGRRIRAEANRERLARVVESTTDY 169
Cdd:COG3829    76 -TGVIQKTGGKGKTVI-------VTAIPifEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKY 135
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 430-509 5.49e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.20  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 430 ATRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPF---HSSRPE---GLGMGLAISRSLMEAMGGSLELADGS-GG 502
Cdd:cd16939    17 HRTVRIALLVSGGR-LTLIVEDDGPGIPAAARERVFEPFvrlDPSRDRatgGFGLGLAIVHRVALWHGGHVECDDSElGG 95


                  ....*..
gi 1798335183 503 AIFTGTL 509
Cdd:cd16939    96 ACFRLTW 102
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 53-161 1.07e-06

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 51.60  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183   53 DGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHD-GFYQQTYRFRAKDGHYVWFETTSRTRRDP 131
Cdd:PRK09776   302 EGQWLQVNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLLSGEiNSYSMEKRYYRRDGEVVWALLAVSLVRDT 381

                           90       100       110
                   ....*....|....*....|....*....|
gi 1798335183  132 ASGELIDVLCVsRDVGRRIRAEANRERLAR 161
Cdd:PRK09776   382 DGTPLYFIAQI-EDINELKRTEQVNERLME 410
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 432-505 1.19e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 48.01  E-value: 1.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1798335183 432 RVEVHAHQsGPREVTFSVSDQGPGVTDDEAQAIF---SPFHSSRPeGLGMGLAISRSLMEAMGGSLELADGS-GGAIF 505
Cdd:cd16954    56 FVEVTARQ-TDGGLHLIVDDDGPGVPESQRSKIFqrgQRLDEQRP-GQGLGLAIAKEIVEQYGGELSLSDSPlGGARF 131
PRK10604 PRK10604
sensor protein RstB; Provisional
 432-506 2.45e-06

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 49.99  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 432 RVEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPF---HSSRPE---GLGMGLAISRSLMEAMGGSLEL-ADGSGGAI 504
Cdd:PRK10604  338 RVRVSLLLDG-NQACLIVEDDGPGIPPEERERVFEPFvrlDPSRDRatgGCGLGLAIVHSIALAMGGSVNCdESELGGAR 416


                  ..
gi 1798335183 505 FT 506
Cdd:PRK10604  417 FS 418
envZ PRK09467
osmolarity sensor protein; Provisional
 429-502 2.50e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 49.91  E-value: 2.50e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1798335183 429 GATRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPF---HSSR-PEGLGMGLAISRSLMEAMGGSLELADGSGG 502
Cdd:PRK09467  347 GNGWIKVSSGTEGKR-AWFQVEDDGPGIPPEQLKHLFQPFtrgDSARgSSGTGLGLAIVKRIVDQHNGKVELGNSEEG 423
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 293-358 3.73e-06

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 44.51  E-value: 3.73e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1798335183 293 GELASNIAHELNQPLGAIANYASGALMQLRTDPGRPASdltlpLTRIDEQVQRLAQRLRHIRAFVR 358
Cdd:cd00082     5 GEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREY-----LERIREEAERLLRLINDLLDLSR 65
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
266-502 4.97e-06

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 48.08  E-value: 4.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 266 IGLRKAAEAQARRHQEQIAHANRLATTGELAsNIAHEL----NQPLGAIANYASGALMQLRTDPGRPASDLtlpltridE 341
Cdd:COG4585    25 VLLRARRAERAAELERELAARAEEAREEERR-RIARELhdgvGQSLSAIKLQLEAARRLLDADPEAAREEL--------E 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 342 QVQRLAQR-LRHIRAFVRkgQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADpIALE-----Qvlvn 415
Cdd:COG4585    96 EIRELAREaLAELRRLVR--GLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPE-VELAlyrivQ---- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 416 lllnalEA---SREQPGATRVEVHAHQSgPREVTFSVSDQGPGvtddeaqaifspFHSSRPEGLGMGLAISRSLMEAMGG 492
Cdd:COG4585   169 ------EAltnALKHAGATRVTVTLEVD-DGELTLTVRDDGVG------------FDPEAAPGGGLGLRGMRERAEALGG 229

                         250
                  ....*....|
gi 1798335183 493 SLELADGSGG 502
Cdd:COG4585   230 TLTIGSAPGG 239
PRK13560 PRK13560
hypothetical protein; Provisional
 29-191 8.21e-06

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 48.52  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  29 LDEEKRHYQWLAESTTDLISRHARDGTFLYASQAARDLLGYEPEELIGVSAYDLFHPSDLADLLNKSPRVYYHDGFYQQT 108
Cdd:PRK13560  199 IDEALHFLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHDFAPAQPADDYQEADAAKFDADGSQIIE 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 109 YRFRAKDGHYVWFETT-SRTRRDPASGELIDVLCVSRDVGRRIRAEA----NRERLARVVESTTDYVLFCDGDERL-FYS 182
Cdd:PRK13560  279 AEFQNKDGRTRPVDVIfNHAEFDDKENHCAGLVGAITDISGRRAAERelleKEDMLRAIIEAAPIAAIGLDADGNIcFVN 358


                  ....*....
gi 1798335183 183 NEAARRLLG 191
Cdd:PRK13560  359 NNAAERMLG 367
PRK13560 PRK13560
hypothetical protein; Provisional
 53-207 1.78e-05

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 47.74  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  53 DGTFLY-----ASQAARDLLGYEPEELIGVSAYdLFHPSDlADLLNKSPR--------VYYHDGFYQQTYRFRAKDGHyv 119
Cdd:PRK13560   89 DGTFSFpslldANGELAAIAKHDLMADKGLLAM-LIGGDD-GDFFFANPFrsaetiamALQSDDWQEEEGHFRCGDGR-- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 120 WFETTSRTRRDPASGELIDvlCVSRDVGRRIRAEANRER----LARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPRE 195
Cdd:PRK13560  165 FIDCCLRFERHAHADDQVD--GFAEDITERKRAEERIDEalhfLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRRE 242

                         170
                  ....*....|..
gi 1798335183 196 GLGARLEQAYTP 207
Cdd:PRK13560  243 EIIGMSIHDFAP 254
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 293-361 2.84e-05

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 42.17  E-value: 2.84e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1798335183  293 GELASNIAHELNQPLGAIANYASGALMQLRTDPGRPAsdltlpLTRIDEQVQRLAQRLRHIRAFVRKGQ 361
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREY------LETILREAERLLRLINDLLDLSRIEA 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 293-361 4.37e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 41.43  E-value: 4.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1798335183 293 GELASNIAHELNQPLGAIANYASGALMQLRTDPGRPAsdltlpLTRIDEQVQRLAQRLRHIRAFVRKGQ 361
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREY------LETILRSAERLLRLINDLLDLSRIEA 65
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 443-496 7.59e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 42.50  E-value: 7.59e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 443 REVTFSVSDQGPGVTDDEAQAIFSPFHS------SRPEGLGMGLAISRSLMEAMGGSLEL 496
Cdd:cd16947    51 KHVYIDIWDKGKGISETEKDHVFERLYTledsrnSAKQGNGLGLTITKRLAESMGGSIYV 110
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 422-506 1.04e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.90  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 422 EASREQPGAT-RVEVHaHQSGprEVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLMEAMGGSLELAdgS 500
Cdd:PRK11086  447 EAVGGEEGGEiSVSLH-YRNG--WLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVE--S 521


                  ....*.
gi 1798335183 501 GGAIFT 506
Cdd:PRK11086  522 EPGVGT 527
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 166-266 2.23e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 40.69  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 166 TTDYVLFCDGDERLFYSNEAARRLLGLPR-EGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEMPGPQGA-VPVL 243
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPeELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSvIWVL 80

                          90       100
                  ....*....|....*....|...
gi 1798335183 244 SVVLAHRGPGAEPDHLSLLNRDI 266
Cdd:cd00130    81 VSLTPIRDEGGEVIGLLGVVRDI 103
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 106-146 2.47e-04

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 38.70  E-value: 2.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1798335183  106 QQTYRFRAKDGHYVWFETTSRTRRDpASGELIDVLCVSRDV 146
Cdd:smart00086   1 TVEYRLRRKDGSYIWVLVSASPIRD-EDGEVEGILGVVRDI 40
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 163-271 2.50e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 40.48  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 163 VESTTDYVLFCDGDERLFYSNEAARRLLGL-PREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEMPGPQGAVP 241
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLpPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERH 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1798335183 242 VLSVVLAHRGPGAEPDHLSLLNRDIGLRKA 271
Cdd:pfam08448  81 YELRLTPLRDPDGEVIGVLVISRDITERRR 110
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 157-195 4.63e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.53  E-value: 4.63e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1798335183  157 ERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPRE 195
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPE 39
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 425-496 4.69e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 40.06  E-value: 4.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1798335183 425 REQPGATRVEVHAHQSGP-REVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAIS--RSLMEAMGGSLEL 496
Cdd:cd16919    27 SNQRVDADYALNYRDLIPgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSmvYGFVKQSGGHLRI 101
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
287-521 5.70e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 42.31  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 287 NRLATTGE--------LASNIAHELNQPLGAIanyaSGALMQLRTDPGRPASDlTLP--------LTRIDEQVQRLAQRL 350
Cdd:PRK10549  227 NQLASTLEkneqmrrdFMADISHELRTPLAVL----RGELEAIQDGVRKFTPE-SVAslqaevgtLTKLVDDLHQLSLSD 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 351 RHIRAFvRKGQTRPRPvvLLDVVDAACRlceWQYQQAGIALEHELAEALPrVQADPIALEQVLVNLLlnalEAS-REQPG 429
Cdd:PRK10549  302 EGALAY-RKTPVDLVP--LLEVAGGAFR---ERFASRGLTLQLSLPDSAT-VFGDPDRLMQLFNNLL----ENSlRYTDS 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 430 ATRVEVHAHQSGPReVTFSVSDQGPGVTDDEAQAIFSPFH---SSRPE---GLGMGLAISRSLMEAMGGSLeLADGS--G 501
Cdd:PRK10549  371 GGSLHISAEQRDKT-LRLTFADSAPGVSDEQLQKLFERFYrteGSRNRasgGSGLGLAICLNIVEAHNGRI-IAAHSpfG 448

                         250       260
                  ....*....|....*....|
gi 1798335183 502 GAIFTGTLlseanPIHRSVS 521
Cdd:PRK10549  449 GVSITVEL-----PLERDLQ 463
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 157-266 7.54e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 39.32  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 157 ERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPR-EGLGARLEQAYTPGSLTILREIVLPAVARYGSW-SGELEMP 234
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSReEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESrGFEVSFR 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1798335183 235 GPQGA-VPVLSVVLAHRGPGAEPDHLSLLNRDI 266
Cdd:pfam00989  81 VPDGRpRHVEVRASPVRDAGGEILGFLGVLRDI 113
PRK10490 PRK10490
sensor protein KdpD; Provisional
 369-515 1.55e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 41.17  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183 369 LLDVVDAACRLCEwqYQQAGIALEHELAEALPRVQADPIALEQVLVNLLLNALEASREQpgaTRVEVHAHQSGPReVTFS 448
Cdd:PRK10490  741 LEEVVGSALQMLE--PGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQ---AEIGIDAHVEGER-LQLD 814

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1798335183 449 VSDQGPGVTDDEAQAIFSPFHSSRPE----GLGMGLAISRSLMEAMGGSLELADG-SGGAIFTGTLLSEANP 515
Cdd:PRK10490  815 VWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRpEGGACFRVTLPLETPP 886
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 440-496 2.73e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.86  E-value: 2.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1798335183 440 SGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPE-------------------GLGMGLAISRSLMEAMGGSLEL 496
Cdd:cd16929    79 KGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQpslddfsdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDL 154
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
429-482 4.24e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 39.53  E-value: 4.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1798335183 429 GATRVEVH--AHQSGpreVTFSVSDQGPGVTDDEAQAIFSPF---------HSSrpeGLGMGLAI 482
Cdd:PRK09470  369 SHTKIEVAfsVDKDG---LTITVDDDGPGVPEEEREQIFRPFyrvdeardrESG---GTGLGLAI 427
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
433-503 4.38e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 39.62  E-value: 4.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1798335183 433 VEVHAHQSGpREVTFSVSDQGPGVTDDEAQAIFSPFHSS---RPeGLGMGLAISRSLMEAMGGSLELADGS-GGA 503
Cdd:PRK10815  398 VEISARQTD-EHLHIVVEDDGPGIPESKRELIFDRGQRAdtlRP-GQGLGLSVAREITEQYEGKISAGDSPlGGA 470
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 102-510 5.63e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 39.47  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  102 DGFYQQ---------TYRFRAKDGHYVWFETTSRTRRDPASGELIDVLCVSRDVGRRIRAE-ANRERLARVVESTTDYVL 171
Cdd:COG3321    850 SALYPGrgrrrvplpTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLAlAAAAAAALALAAAALAAL 929

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  172 FCDGDERLFYSNEAARRLLGLPREGLGARLEQAYTPGSLTILREIVLPAVARYGSWSGELEMPGPQGAVPVLSVVLAHRG 251
Cdd:COG3321    930 LALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAA 1009

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  252 PGAEPD----HLSLLNRDIGLRKAAEAQARRHQEQIAHANRLATTGELASNIAHELNQPLGAIANYASGALMQLRTDPGR 327
Cdd:COG3321   1010 LLLAAAaaaaALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAA 1089

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  328 PASDLTLPLTRIDEQVQRLAQRLRHIRAFVRKGQTRPRPVVLLDVVDAACRLCEWQYQQAGIALEHELAEALPRVQADPI 407
Cdd:COG3321   1090 LAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLA 1169

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1798335183  408 ALEQVLVNLLLNALEASREQPGATRVEVHAHQSGPREVTFSVSDQGPGVTDDEAQAIFSPFHSSRPEGLGMGLAISRSLM 487
Cdd:COG3321   1170 AAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALA 1249

                          410       420
                   ....*....|....*....|...
gi 1798335183  488 EAMGGSLELADGSGGAIFTGTLL 510
Cdd:COG3321   1250 AAAAALLAALAALALLAAAAGLA 1272
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 148-195 8.89e-03

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 38.60  E-value: 8.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1798335183 148 RRIRAEANRERLARVVESTTDYVLFCDGDERLFYSNEAARRLLGLPRE 195
Cdd:COG3829     2 EELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPRE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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