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Conserved domains on  [gi|17978471|ref|NP_006086|]
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phospholipid-transporting ATPase IA isoform a [Homo sapiens]

Protein Classification

phospholipid-transporting P-type ATPase( domain architecture ID 11492988)

phospholipid-transporting P-type ATPase is the catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids across membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
49-1086 0e+00

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


:

Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 1461.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     49 FCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADN 128
Cdd:TIGR01652    1 FCSNKISTTKYTVLTFLPKNLFEQFKRFANLYFLVVALLQQVPILSPTYRGTSIVPLAFVLIVTAIKEAIEDIRRRRRDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    129 AVNKKQTQVLRNGA-WEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIK 207
Cdd:TIGR01652   81 EVNNRLTEVLEGHGqFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDGVCYVETANLDGETNLKLRQALEETQKML 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    208 DVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKL 287
Cdd:TIGR01652  161 DEDDIKNFSGEIECEQPNASLYSFQGNMTINGDRQYPLSPDNILLRGCTLRNTDWVIGVVVYTGHDTKLMRNATQAPSKR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    288 SNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNL---NYGGASNFGLNFLTFIILFNNLIPISLLVTLE 364
Cdd:TIGR01652  241 SRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAHGKDLWYIRLdvsERNAAANGFFSFLTFLILFSSLIPISLYVSLE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    365 VVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGH-VPEPEDY--- 440
Cdd:TIGR01652  321 LVKSVQAYFINSDLQMYHEKTDTPASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYGDgFTEIKDGire 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    441 -GCSPDEWQNSQFGDEK--TFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGD---KIIYQAASPDEGALVRA 514
Cdd:TIGR01652  401 rLGSYVENENSMLVESKgfTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVPEFNDDgpeEITYQAASPDEAALVKA 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    515 AKQLNFVFTGRTP--DSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAE-TSKYKEI 591
Cdd:TIGR01652  481 ARDVGFVFFERTPksISLLIEMHGETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFKRLSSgGNQVNEE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    592 TLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETI 671
Cdd:TIGR01652  561 TKEHLENYASEGLRTLCIAYRELSEEEYEEWNEEYNEASTALTDREEKLDVVAESIEKDLILLGATAIEDKLQEGVPETI 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    672 ETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTR---ETLSRHCTTLGDALR---KENDFALIID 745
Cdd:TIGR01652  641 ELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVITSDSLDATRsveAAIKFGLEGTSEEFNnlgDSGNVALVID 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    746 GKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQ 825
Cdd:TIGR01652  721 GKSLGYALDEELEKEFLQLALKCKAVICCRVSPSQKADVVRLVKKSTGKTTLAIGDGANDVSMIQEADVGVGISGKEGMQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    826 AANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPP 905
Cdd:TIGR01652  801 AVMASDFAIGQFRFLTKLLLVHGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEGWYMVLYNVFFTALPV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    906 LTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVY 985
Cdd:TIGR01652  881 ISLGVFDQDVSASLSLRYPQLYREGQKGQGFSTKTFWGWMLDGIYQSLVIFFFPMFAYILGDFVSSGSVDDFSSVGVIVF 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    986 TFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPaipmAPDMSGEAAMLFSSGVFWMGLLFIPVASLLL 1065
Cdd:TIGR01652  961 TALVVIVNLKIALEINRWNWISLITIWGSILVWLIFVIVYSSIFP----SPAFYKAAPRVMGTFGFWLVLLVIVLISLLP 1036
                         1050      1060
                   ....*....|....*....|.
gi 17978471   1066 DVVYKVIKRTAFKTLVDEVQE 1086
Cdd:TIGR01652 1037 RFTYKAIQRLFRPPDYDIVQE 1057
 
Name Accession Description Interval E-value
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
49-1086 0e+00

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 1461.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     49 FCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADN 128
Cdd:TIGR01652    1 FCSNKISTTKYTVLTFLPKNLFEQFKRFANLYFLVVALLQQVPILSPTYRGTSIVPLAFVLIVTAIKEAIEDIRRRRRDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    129 AVNKKQTQVLRNGA-WEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIK 207
Cdd:TIGR01652   81 EVNNRLTEVLEGHGqFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDGVCYVETANLDGETNLKLRQALEETQKML 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    208 DVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKL 287
Cdd:TIGR01652  161 DEDDIKNFSGEIECEQPNASLYSFQGNMTINGDRQYPLSPDNILLRGCTLRNTDWVIGVVVYTGHDTKLMRNATQAPSKR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    288 SNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNL---NYGGASNFGLNFLTFIILFNNLIPISLLVTLE 364
Cdd:TIGR01652  241 SRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAHGKDLWYIRLdvsERNAAANGFFSFLTFLILFSSLIPISLYVSLE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    365 VVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGH-VPEPEDY--- 440
Cdd:TIGR01652  321 LVKSVQAYFINSDLQMYHEKTDTPASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYGDgFTEIKDGire 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    441 -GCSPDEWQNSQFGDEK--TFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGD---KIIYQAASPDEGALVRA 514
Cdd:TIGR01652  401 rLGSYVENENSMLVESKgfTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVPEFNDDgpeEITYQAASPDEAALVKA 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    515 AKQLNFVFTGRTP--DSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAE-TSKYKEI 591
Cdd:TIGR01652  481 ARDVGFVFFERTPksISLLIEMHGETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFKRLSSgGNQVNEE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    592 TLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETI 671
Cdd:TIGR01652  561 TKEHLENYASEGLRTLCIAYRELSEEEYEEWNEEYNEASTALTDREEKLDVVAESIEKDLILLGATAIEDKLQEGVPETI 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    672 ETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTR---ETLSRHCTTLGDALR---KENDFALIID 745
Cdd:TIGR01652  641 ELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVITSDSLDATRsveAAIKFGLEGTSEEFNnlgDSGNVALVID 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    746 GKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQ 825
Cdd:TIGR01652  721 GKSLGYALDEELEKEFLQLALKCKAVICCRVSPSQKADVVRLVKKSTGKTTLAIGDGANDVSMIQEADVGVGISGKEGMQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    826 AANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPP 905
Cdd:TIGR01652  801 AVMASDFAIGQFRFLTKLLLVHGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEGWYMVLYNVFFTALPV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    906 LTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVY 985
Cdd:TIGR01652  881 ISLGVFDQDVSASLSLRYPQLYREGQKGQGFSTKTFWGWMLDGIYQSLVIFFFPMFAYILGDFVSSGSVDDFSSVGVIVF 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    986 TFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPaipmAPDMSGEAAMLFSSGVFWMGLLFIPVASLLL 1065
Cdd:TIGR01652  961 TALVVIVNLKIALEINRWNWISLITIWGSILVWLIFVIVYSSIFP----SPAFYKAAPRVMGTFGFWLVLLVIVLISLLP 1036
                         1050      1060
                   ....*....|....*....|.
gi 17978471   1066 DVVYKVIKRTAFKTLVDEVQE 1086
Cdd:TIGR01652 1037 RFTYKAIQRLFRPPDYDIVQE 1057
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
51-959 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 1402.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   51 NNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 130
Cdd:cd02073    1 DNRISTTKYTVFTFLPKNLFEQFRRVANLYFLFIAILQQIPGISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKSDNEV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  131 NKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVD 210
Cdd:cd02073   81 NNRPVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDGLCYVETANLDGETNLKIRQALPETALLLSEE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  211 SLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNV 290
Cdd:cd02073  161 DLARFSGEIECEQPNNDLYTFNGTLELNGGRELPLSPDNLLLRGCTLRNTEWVYGVVVYTGHETKLMLNSGGTPLKRSSI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  291 ERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNL--NYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKF 368
Cdd:cd02073  241 EKKMNRFIIAIFCILIVMCLISAIGKGIWLSKHGRDLWYLLPkeERSPALEFFFDFLTFIILYNNLIPISLYVTIEVVKF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  369 TQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGhvpepedygcspdewq 448
Cdd:cd02073  321 LQSFFINWDLDMYDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYG---------------- 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  449 nsqfgdektfsdssllenlqnnhptapiiceFLTMMAVCHTAVPEREG--DKIIYQAASPDEGALVRAAKQLNFVFTGRT 526
Cdd:cd02073  385 -------------------------------FFLALALCHTVVPEKDDhpGQLVYQASSPDEAALVEAARDLGFVFLSRT 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  527 PDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLA-ETSKYKEITLKHLEQFATEGLR 605
Cdd:cd02073  434 PDTVTINALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSpSSLELVEKTQEHLEDFASEGLR 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  606 TLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILT 685
Cdd:cd02073  514 TLCLAYREISEEEYEEWNEKYDEASTALQNREELLDEVAEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLT 593
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  686 GDKQETAINIGHSCKLLKKNMgmivinegsldgtretlsrhcttlgdalrkeNDFALIIDGKTLKYALTFGVRQYFLDLA 765
Cdd:cd02073  594 GDKQETAINIGYSCRLLSEDM-------------------------------ENLALVIDGKTLTYALDPELERLFLELA 642
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  766 LSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLM 845
Cdd:cd02073  643 LKCKAVICCRVSPLQKALVVKLVKKSKKAVTLAIGDGANDVSMIQEAHVGVGISGQEGMQAARASDYAIAQFRFLRRLLL 722
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  846 IHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPE 925
Cdd:cd02073  723 VHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQFFNGFSGQTLYDSWYLTLYNVLFTSLPPLVIGIFDQDVSAETLLRYPE 802
                        890       900       910
                 ....*....|....*....|....*....|....
gi 17978471  926 LYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFP 959
Cdd:cd02073  803 LYKPGQLNELFNWKVFLYWILDGIYQSLIIFFVP 836
PLN03190 PLN03190
aminophospholipid translocase; Provisional
5-1072 0e+00

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 800.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     5 RRTVSEIRSRAEGYEKTDDV-------------SEKTSLADQE----EVRTIFINQPQLT----KFCNNHVSTAKYNIIT 63
Cdd:PLN03190   22 RRSVSSKDSRSVREVTFGDLgsrpvrhgsrgadSEMFSMSQKEisdeDARLVYLNDPEKSnerfEFAGNSIRTAKYSVFS 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    64 FLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAW 143
Cdd:PLN03190  102 FLPRNLFEQFHRVAYIYFLVIAVLNQLPQLAVFGRGASILPLAFVLLVTAVKDAYEDWRRHRSDRIENNRLAWVLVDDQF 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   144 EIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATsdIKDVDSLMRISGRIECES 223
Cdd:PLN03190  182 QEKKWKDIRVGEIIKIQANDTLPCDMVLLSTSDPTGVAYVQTINLDGESNLKTRYAKQET--LSKIPEKEKINGLIKCEK 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   224 PNRHLYDFVGNIRLDGHgTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFC 303
Cdd:PLN03190  260 PNRNIYGFQANMEVDGK-RLSLGPSNIILRGCELKNTAWAIGVAVYCGRETKAMLNNSGAPSKRSRLETRMNLEIIILSL 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   304 ILIAMSLVCSVGSAIWNRRHSGKDWYL--------------NLNY-GGASNFGLNFLTFIILFNNLIPISLLVTLEVVKF 368
Cdd:PLN03190  339 FLIALCTIVSVCAAVWLRRHRDELDTIpfyrrkdfseggpkNYNYyGWGWEIFFTFLMSVIVFQIMIPISLYISMELVRV 418
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   369 TQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDygcsPDEWQ 448
Cdd:PLN03190  419 GQAYFMIRDDQMYDEASNSRFQCRALNINEDLGQIKYVFSDKTGTLTENKMEFQCASIWGVDYSDGRTPTQ----NDHAG 494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   449 NSQFGDEKTFS-------DSSLLENLQNNHPTAPI--ICEFLTMMAVCHTAVPEREGDK-------IIYQAASPDEGALV 512
Cdd:PLN03190  495 YSVEVDGKILRpkmkvkvDPQLLELSKSGKDTEEAkhVHDFFLALAACNTIVPIVVDDTsdptvklMDYQGESPDEQALV 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   513 RAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEI- 591
Cdd:PLN03190  575 YAAAAYGFMLIERTSGHIVIDIHGERQRFNVLGLHEFDSDRKRMSVILGCPDKTVKVFVKGADTSMFSVIDRSLNMNVIr 654
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   592 -TLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPET 670
Cdd:PLN03190  655 aTEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSFEAASTALIGRAALLRKVASNVENNLTILGASAIEDKLQQGVPEA 734
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   671 IETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETL------SRHCTTLGDALRK-------- 736
Cdd:PLN03190  735 IESLRTAGIKVWVLTGDKQETAISIGYSSKLLTNKMTQIIINSNSKESCRKSLedalvmSKKLTTVSGISQNtggssaaa 814
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   737 ENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGV 816
Cdd:PLN03190  815 SDPVALIIDGTSLVYVLDSELEEQLFQLASKCSVVLCCRVAPLQKAGIVALVKNRTSDMTLAIGDGANDVSMIQMADVGV 894
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   817 GISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLY 896
Cdd:PLN03190  895 GISGQEGRQAVMASDFAMGQFRFLVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLVLFWYVLFTCFTLTTAINEWSSVLY 974
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   897 NVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQygtafgnGKTSD 976
Cdd:PLN03190  975 SVIYTALPTIVVGILDKDLSRRTLLKYPQLYGAGQRQEAYNSKLFWLTMIDTLWQSAVVFFVPLFAYW-------ASTID 1047
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   977 YLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIalwVVFFgIYSSLWPAIPMAPdmsGEAAM--LFSSGVFWMG 1054
Cdd:PLN03190 1048 GSSIGDLWTLAVVILVNLHLAMDIIRWNWITHAAIWGSI---VATF-ICVIVIDAIPTLP---GYWAIfhIAKTGSFWLC 1120
                        1130
                  ....*....|....*...
gi 17978471  1055 LLFIPVASLLLDVVYKVI 1072
Cdd:PLN03190 1121 LLAIVVAALLPRFVVKVL 1138
PhoLip_ATPase_C pfam16212
Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the ...
827-1079 1.45e-108

Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the C-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 465071 [Multi-domain]  Cd Length: 250  Bit Score: 339.87  E-value: 1.45e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    827 ANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPL 906
Cdd:pfam16212    1 ARASDYAIAQFRFLKRLLLVHGRWSYRRTSKLILYFFYKNIVFTLTQFWYQFYNGFSGQSLYESWYLTLYNLLFTSLPVI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    907 TLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLkALQYGTAFGNGKTSDYLLLGNFVYT 986
Cdd:pfam16212   81 VLGIFDQDVSAETLLAYPELYKLGQKNKFFNLKTFLGWMLDGIYQSLIIFFIPY-LAYGDSVFSGGKDADLWAFGTTVFT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    987 FVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMapDMSGEAAMLFSSGVFWMGLLFIPVASLLLD 1066
Cdd:pfam16212  160 ALVLVVNLKLALETHYWTWITHLAIWGSILLYFLFTLIYSSIYPSSYS--VFYGVASRLFGSPSFWLTLLLIVVVALLPD 237
                          250
                   ....*....|...
gi 17978471   1067 VVYKVIKRTAFKT 1079
Cdd:pfam16212  238 FAYKALKRTFFPT 250
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
106-1074 1.51e-42

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 168.75  E-value: 1.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  106 LFILAVAAIKEIIEDIKRHKADNAVN--KK----QTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEpqa 179
Cdd:COG0474   85 IVILAVVLLNAIIGFVQEYRAEKALEalKKllapTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKD--- 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  180 mCYIETSNLDGETnlkirqgLPATsdiKDVDSLmrisgrieceSPNRHLYD-----FVGNIRLDGHGTvplgadqillrg 254
Cdd:COG0474  162 -LQVDESALTGES-------VPVE---KSADPL----------PEDAPLGDrgnmvFMGTLVTSGRGT------------ 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  255 aqlrntqwvhGIVVYTGHDT------KLMQNSTSP--PLKLsNVERITNVqiLILFCILIAMsLVCSVGSAiwnrrhSGK 326
Cdd:COG0474  209 ----------AVVVATGMNTefgkiaKLLQEAEEEktPLQK-QLDRLGKL--LAIIALVLAA-LVFLIGLL------RGG 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  327 DWYLNlnyggasnfglnFLTFIILFNNLIPISLLVtleVVKFTQAyfINwdldmhyeptdTAAMAR----TSNLN--EEL 400
Cdd:COG0474  269 PLLEA------------LLFAVALAVAAIPEGLPA---VVTITLA--LG-----------AQRMAKrnaiVRRLPavETL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  401 GQVKYIFSDKTGTLTCNVMQFKKCTIAGVAY---GHVPEPEDygcspdewqnsqfgdektfsdssllenlqnnhptapii 477
Cdd:COG0474  321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYevtGEFDPALE-------------------------------------- 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  478 cEFLTMMAVCHTAVPERE---GDkiiyqaasPDEGALVRAAKQLNfvftgrtpdsviIDSLGQEERYELLNVLEFTSARK 554
Cdd:COG0474  363 -ELLRAAALCSDAQLEEEtglGD--------PTEGALLVAAAKAG------------LDVEELRKEYPRVDEIPFDSERK 421
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  555 RMSVIVRTPSGKLRLYCKGADTVIYDR----------LAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDfqewra 624
Cdd:COG0474  422 RMSTVHEDPDGKRLLIVKGAPEVVLALctrvltgggvVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPADP------ 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  625 vyqrastsvqnrllklEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckllkK 704
Cdd:COG0474  496 ----------------ELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIA-------R 552
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  705 NMGMIVINEGSLDGTR-ETLSRHctTLGDALRKENDFAliidgktlkyaltfgvrqyfldlalsckaviccRVSPLQKSE 783
Cdd:COG0474  553 QLGLGDDGDRVLTGAElDAMSDE--ELAEAVEDVDVFA---------------------------------RVSPEHKLR 597
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  784 VVEMVKKQVKVV--TlaiGDGANDVSMIQTAHVGV--GISGNEglqAA-NSSDYSIAQfkylKNLLMIHGAWNYNRVskc 858
Cdd:COG0474  598 IVKALQANGHVVamT---GDGVNDAPALKAADIGIamGITGTD---VAkEAADIVLLD----DNFATIVAAVEEGRR--- 664
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  859 IlycfYKNI---VLYII-----EIWFAFVNGFSG--------QILFerwciglyNVMFTAMPP-LTLGiFERScRKENML 921
Cdd:COG0474  665 I----YDNIrkfIKYLLssnfgEVLSVLLASLLGlplpltpiQILW--------INLVTDGLPaLALG-FEPV-EPDVMK 730
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  922 KYPElyktSQNALDFNTKVFWVHCLNGLFHSVILFWFplkalqYGTAFGNGKTSDY--------LLLGNFVYTFVVitvc 993
Cdd:COG0474  731 RPPR----WPDEPILSRFLLLRILLLGLLIAIFTLLT------FALALARGASLALartmafttLVLSQLFNVFNC---- 796
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  994 lkaglETSYWTWFsHIAIWGSIALWVVFFGIYSSLWpAIPMAPDMSGeaamLFS----SGVFWMGLLFIPVASLLLDVVY 1069
Cdd:COG0474  797 -----RSERRSFF-KSGLFPNRPLLLAVLLSLLLQL-LLIYVPPLQA----LFGtvplPLSDWLLILGLALLYLLLVELV 865

                 ....*
gi 17978471 1070 KVIKR 1074
Cdd:COG0474  866 KLLRR 870
 
Name Accession Description Interval E-value
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
49-1086 0e+00

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 1461.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     49 FCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADN 128
Cdd:TIGR01652    1 FCSNKISTTKYTVLTFLPKNLFEQFKRFANLYFLVVALLQQVPILSPTYRGTSIVPLAFVLIVTAIKEAIEDIRRRRRDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    129 AVNKKQTQVLRNGA-WEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIK 207
Cdd:TIGR01652   81 EVNNRLTEVLEGHGqFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDGVCYVETANLDGETNLKLRQALEETQKML 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    208 DVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKL 287
Cdd:TIGR01652  161 DEDDIKNFSGEIECEQPNASLYSFQGNMTINGDRQYPLSPDNILLRGCTLRNTDWVIGVVVYTGHDTKLMRNATQAPSKR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    288 SNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNL---NYGGASNFGLNFLTFIILFNNLIPISLLVTLE 364
Cdd:TIGR01652  241 SRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAHGKDLWYIRLdvsERNAAANGFFSFLTFLILFSSLIPISLYVSLE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    365 VVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGH-VPEPEDY--- 440
Cdd:TIGR01652  321 LVKSVQAYFINSDLQMYHEKTDTPASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYGDgFTEIKDGire 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    441 -GCSPDEWQNSQFGDEK--TFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGD---KIIYQAASPDEGALVRA 514
Cdd:TIGR01652  401 rLGSYVENENSMLVESKgfTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVPEFNDDgpeEITYQAASPDEAALVKA 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    515 AKQLNFVFTGRTP--DSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAE-TSKYKEI 591
Cdd:TIGR01652  481 ARDVGFVFFERTPksISLLIEMHGETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFKRLSSgGNQVNEE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    592 TLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETI 671
Cdd:TIGR01652  561 TKEHLENYASEGLRTLCIAYRELSEEEYEEWNEEYNEASTALTDREEKLDVVAESIEKDLILLGATAIEDKLQEGVPETI 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    672 ETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTR---ETLSRHCTTLGDALR---KENDFALIID 745
Cdd:TIGR01652  641 ELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVITSDSLDATRsveAAIKFGLEGTSEEFNnlgDSGNVALVID 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    746 GKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQ 825
Cdd:TIGR01652  721 GKSLGYALDEELEKEFLQLALKCKAVICCRVSPSQKADVVRLVKKSTGKTTLAIGDGANDVSMIQEADVGVGISGKEGMQ 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    826 AANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPP 905
Cdd:TIGR01652  801 AVMASDFAIGQFRFLTKLLLVHGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEGWYMVLYNVFFTALPV 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    906 LTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVY 985
Cdd:TIGR01652  881 ISLGVFDQDVSASLSLRYPQLYREGQKGQGFSTKTFWGWMLDGIYQSLVIFFFPMFAYILGDFVSSGSVDDFSSVGVIVF 960
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    986 TFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPaipmAPDMSGEAAMLFSSGVFWMGLLFIPVASLLL 1065
Cdd:TIGR01652  961 TALVVIVNLKIALEINRWNWISLITIWGSILVWLIFVIVYSSIFP----SPAFYKAAPRVMGTFGFWLVLLVIVLISLLP 1036
                         1050      1060
                   ....*....|....*....|.
gi 17978471   1066 DVVYKVIKRTAFKTLVDEVQE 1086
Cdd:TIGR01652 1037 RFTYKAIQRLFRPPDYDIVQE 1057
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
51-959 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 1402.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   51 NNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 130
Cdd:cd02073    1 DNRISTTKYTVFTFLPKNLFEQFRRVANLYFLFIAILQQIPGISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKSDNEV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  131 NKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVD 210
Cdd:cd02073   81 NNRPVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDGLCYVETANLDGETNLKIRQALPETALLLSEE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  211 SLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNV 290
Cdd:cd02073  161 DLARFSGEIECEQPNNDLYTFNGTLELNGGRELPLSPDNLLLRGCTLRNTEWVYGVVVYTGHETKLMLNSGGTPLKRSSI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  291 ERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNL--NYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKF 368
Cdd:cd02073  241 EKKMNRFIIAIFCILIVMCLISAIGKGIWLSKHGRDLWYLLPkeERSPALEFFFDFLTFIILYNNLIPISLYVTIEVVKF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  369 TQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGhvpepedygcspdewq 448
Cdd:cd02073  321 LQSFFINWDLDMYDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYG---------------- 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  449 nsqfgdektfsdssllenlqnnhptapiiceFLTMMAVCHTAVPEREG--DKIIYQAASPDEGALVRAAKQLNFVFTGRT 526
Cdd:cd02073  385 -------------------------------FFLALALCHTVVPEKDDhpGQLVYQASSPDEAALVEAARDLGFVFLSRT 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  527 PDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLA-ETSKYKEITLKHLEQFATEGLR 605
Cdd:cd02073  434 PDTVTINALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSpSSLELVEKTQEHLEDFASEGLR 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  606 TLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILT 685
Cdd:cd02073  514 TLCLAYREISEEEYEEWNEKYDEASTALQNREELLDEVAEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLT 593
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  686 GDKQETAINIGHSCKLLKKNMgmivinegsldgtretlsrhcttlgdalrkeNDFALIIDGKTLKYALTFGVRQYFLDLA 765
Cdd:cd02073  594 GDKQETAINIGYSCRLLSEDM-------------------------------ENLALVIDGKTLTYALDPELERLFLELA 642
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  766 LSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLM 845
Cdd:cd02073  643 LKCKAVICCRVSPLQKALVVKLVKKSKKAVTLAIGDGANDVSMIQEAHVGVGISGQEGMQAARASDYAIAQFRFLRRLLL 722
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  846 IHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPE 925
Cdd:cd02073  723 VHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQFFNGFSGQTLYDSWYLTLYNVLFTSLPPLVIGIFDQDVSAETLLRYPE 802
                        890       900       910
                 ....*....|....*....|....*....|....
gi 17978471  926 LYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFP 959
Cdd:cd02073  803 LYKPGQLNELFNWKVFLYWILDGIYQSLIIFFVP 836
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
51-957 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 1098.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   51 NNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 130
Cdd:cd07536    1 DNSISNQKYNVFTFLPGVLYEQFKRFLNLYFLVIACLQFVPALKPGYLYTTWAPLIFILAVTMTKEAIDDFRRFQRDKEV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  131 NKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVD 210
Cdd:cd07536   81 NKKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQGSCYVETAQLDGETDLKLRVAVSCTQQLPALG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  211 SLMRISGRIECESPNRHLYDFVGNIRLDGHGT---VPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKL 287
Cdd:cd07536  161 DLMKISAYVECQKPQMDIHSFEGNFTLEDSDPpihESLSIENTLLRASTLRNTGWVIGVVVYTGKETKLVMNTSNAKNKV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  288 SNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVK 367
Cdd:cd07536  241 GLLDLELNRLTKALFLALVVLSLVMVTLQGFWGPWYGEKNWYIKKMDTTSDNFGRNLLRFLLLFSYIIPISLRVNLDMVK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  368 FTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGhvpepedygcspdew 447
Cdd:cd07536  321 AVYAWFIMWDENMYYIGNDTGTVARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIGGVSYG--------------- 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  448 qnsqfgdektfsdssllenlqnnhptapiicefltmmavchtavperegdkiiyqaaspdegalvraakqlnfvftgrtp 527
Cdd:cd07536      --------------------------------------------------------------------------------
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  528 dsviidslGQEERYELLNVLEFTSARKRMSVIVRTPS-GKLRLYCKGADTVIYDRLAETSkYKEITLKHLEQFATEGLRT 606
Cdd:cd07536  386 --------GQVLSFCILQLLEFTSDRKRMSVIVRDEStGEITLYMKGADVAISPIVSKDS-YMEQYNDWLEEECGEGLRT 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  607 LCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTG 686
Cdd:cd07536  457 LCVAKKALTENEYQEWESRYTEASLSLHDRSLRVAEVVESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTG 536
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  687 DKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFgVRQYFLDLAL 766
Cdd:cd07536  537 DKQETAICIAKSCHLVSRTQDIHLLRQDTSRGERAAITQHAHLELNAFRRKHDVALVIDGDSLEVALKY-YRHEFVELAC 615
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  767 SCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMI 846
Cdd:cd07536  616 QCPAVICCRVSPTQKARIVTLLKQHTGRRTLAIGDGGNDVSMIQAADCGVGISGKEGKQASLAADYSITQFRHLGRLLLV 695
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  847 HGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCrKENMLKYPEL 926
Cdd:cd07536  696 HGRNSYNRSAALGQYVFYKGLIISTIQAVFSFVFGFSGVPLFQGFLMVGYNVIYTMFPVFSLVIDQDVK-PESAMLYPQL 774
                        890       900       910
                 ....*....|....*....|....*....|.
gi 17978471  927 YKTSQNALDFNTKVFWVHCLNGLFHSVILFW 957
Cdd:cd07536  775 YKDLQKGRSLNFKTFLGWVLISLYHGGILFY 805
PLN03190 PLN03190
aminophospholipid translocase; Provisional
5-1072 0e+00

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 800.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     5 RRTVSEIRSRAEGYEKTDDV-------------SEKTSLADQE----EVRTIFINQPQLT----KFCNNHVSTAKYNIIT 63
Cdd:PLN03190   22 RRSVSSKDSRSVREVTFGDLgsrpvrhgsrgadSEMFSMSQKEisdeDARLVYLNDPEKSnerfEFAGNSIRTAKYSVFS 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    64 FLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAW 143
Cdd:PLN03190  102 FLPRNLFEQFHRVAYIYFLVIAVLNQLPQLAVFGRGASILPLAFVLLVTAVKDAYEDWRRHRSDRIENNRLAWVLVDDQF 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   144 EIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATsdIKDVDSLMRISGRIECES 223
Cdd:PLN03190  182 QEKKWKDIRVGEIIKIQANDTLPCDMVLLSTSDPTGVAYVQTINLDGESNLKTRYAKQET--LSKIPEKEKINGLIKCEK 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   224 PNRHLYDFVGNIRLDGHgTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFC 303
Cdd:PLN03190  260 PNRNIYGFQANMEVDGK-RLSLGPSNIILRGCELKNTAWAIGVAVYCGRETKAMLNNSGAPSKRSRLETRMNLEIIILSL 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   304 ILIAMSLVCSVGSAIWNRRHSGKDWYL--------------NLNY-GGASNFGLNFLTFIILFNNLIPISLLVTLEVVKF 368
Cdd:PLN03190  339 FLIALCTIVSVCAAVWLRRHRDELDTIpfyrrkdfseggpkNYNYyGWGWEIFFTFLMSVIVFQIMIPISLYISMELVRV 418
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   369 TQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDygcsPDEWQ 448
Cdd:PLN03190  419 GQAYFMIRDDQMYDEASNSRFQCRALNINEDLGQIKYVFSDKTGTLTENKMEFQCASIWGVDYSDGRTPTQ----NDHAG 494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   449 NSQFGDEKTFS-------DSSLLENLQNNHPTAPI--ICEFLTMMAVCHTAVPEREGDK-------IIYQAASPDEGALV 512
Cdd:PLN03190  495 YSVEVDGKILRpkmkvkvDPQLLELSKSGKDTEEAkhVHDFFLALAACNTIVPIVVDDTsdptvklMDYQGESPDEQALV 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   513 RAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEI- 591
Cdd:PLN03190  575 YAAAAYGFMLIERTSGHIVIDIHGERQRFNVLGLHEFDSDRKRMSVILGCPDKTVKVFVKGADTSMFSVIDRSLNMNVIr 654
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   592 -TLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPET 670
Cdd:PLN03190  655 aTEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSFEAASTALIGRAALLRKVASNVENNLTILGASAIEDKLQQGVPEA 734
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   671 IETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETL------SRHCTTLGDALRK-------- 736
Cdd:PLN03190  735 IESLRTAGIKVWVLTGDKQETAISIGYSSKLLTNKMTQIIINSNSKESCRKSLedalvmSKKLTTVSGISQNtggssaaa 814
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   737 ENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGV 816
Cdd:PLN03190  815 SDPVALIIDGTSLVYVLDSELEEQLFQLASKCSVVLCCRVAPLQKAGIVALVKNRTSDMTLAIGDGANDVSMIQMADVGV 894
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   817 GISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLY 896
Cdd:PLN03190  895 GISGQEGRQAVMASDFAMGQFRFLVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLVLFWYVLFTCFTLTTAINEWSSVLY 974
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   897 NVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQygtafgnGKTSD 976
Cdd:PLN03190  975 SVIYTALPTIVVGILDKDLSRRTLLKYPQLYGAGQRQEAYNSKLFWLTMIDTLWQSAVVFFVPLFAYW-------ASTID 1047
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   977 YLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIalwVVFFgIYSSLWPAIPMAPdmsGEAAM--LFSSGVFWMG 1054
Cdd:PLN03190 1048 GSSIGDLWTLAVVILVNLHLAMDIIRWNWITHAAIWGSI---VATF-ICVIVIDAIPTLP---GYWAIfhIAKTGSFWLC 1120
                        1130
                  ....*....|....*...
gi 17978471  1055 LLFIPVASLLLDVVYKVI 1072
Cdd:PLN03190 1121 LLAIVVAALLPRFVVKVL 1138
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
51-943 9.00e-173

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 528.90  E-value: 9.00e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   51 NNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADN-A 129
Cdd:cd07541    1 SNEVRNQKYNIFTFLPKVLYEQFKFFYNLYFLVVALSQFVPALKIGYLYTYWAPLGFVLAVTMAKEAVDDIRRRRRDKeQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  130 VNKKQTQvlrNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDV 209
Cdd:cd07541   81 NYEKLTV---RGETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEKSGSCFIRTDQLDGETDWKLRIAVPCTQKLPEE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  210 DSLMRISGrIECESPNRHLYDFVGNIRLdghgtvplgADQILLRGAQLRNTQW---------VHGIVVYTGHDTKLMQNS 280
Cdd:cd07541  158 GILNSISA-VYAEAPQKDIHSFYGTFTI---------NDDPTSESLSVENTLWantvvasgtVIGVVVYTGKETRSVMNT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  281 TSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIwnrrhsGKDWYLNLnyggasnfglnfLTFIILFNNLIPISLL 360
Cdd:cd07541  228 SQPKNKVGLLDLEINFLTKILFCAVLALSIVMVALQGF------QGPWYIYL------------FRFLILFSSIIPISLR 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  361 VTLEVVKFTQAYFINWDldmhyePTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGhvpepedy 440
Cdd:cd07541  290 VNLDMAKIVYSWQIEHD------KNIPGTVVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSYG-------- 355
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  441 gcspdewqnsqfgdektfsdssllenLQNNHptapiicefltmmavchtavperegdkiiyqaaspdegalvraakqlnf 520
Cdd:cd07541  356 --------------------------GQNLN------------------------------------------------- 360
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  521 vftgrtpdsviidslgqeerYELLNVLEFTSARKRMSVIVRTPS-GKLRLYCKGADTViydrLAETSKYKEITLKHLEQF 599
Cdd:cd07541  361 --------------------YEILQIFPFTSESKRMGIIVREEKtGEITFYMKGADVV----MSKIVQYNDWLEEECGNM 416
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  600 ATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADI 679
Cdd:cd07541  417 AREGLRTLVVAKKKLSEEEYQAFEKRYNAAKLSIHDRDLKVAEVVESLERELELLCLTGVEDKLQEDVKPTLELLRNAGI 496
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  680 KIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSldgTRETLSRHCttlgDALRKENDFALIIDGKTLKYALTFgVRQ 759
Cdd:cd07541  497 KIWMLTGDKLETATCIAKSSKLVSRGQYIHVFRKVT---TREEAHLEL----NNLRRKHDCALVIDGESLEVCLKY-YEH 568
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  760 YFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKY 839
Cdd:cd07541  569 EFIELACQLPAVVCCRCSPTQKAQIVRLIQKHTGKRTCAIGDGGNDVSMIQAADVGVGIEGKEGKQASLAADFSITQFSH 648
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  840 LKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLgIFERSCRKEN 919
Cdd:cd07541  649 IGRLLLWHGRNSYKRSAKLAQFVMHRGLIISIMQAVFSSVFYFAPIALYQGFLMVGYSTIYTMAPVFSL-VLDQDVSEEL 727
                        890       900
                 ....*....|....*....|....*.
gi 17978471  920 MLKYPELYK--TSQNALDFNTKVFWV 943
Cdd:cd07541  728 AMLYPELYKelTKGRSLSYKTFFIWV 753
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
99-880 2.42e-117

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 374.73  E-value: 2.42e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471     99 YTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGaWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSepq 178
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNG-WKEISSKDLVPGDVVLVKSGDTVPADGVLLSGS--- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    179 amCYIETSNLDGETNLKIRQGLPatsdikdvdslmrisgriECESPNRHLYDFVGNIrldghgTVPLGADQILlrgaqlr 258
Cdd:TIGR01494   77 --AFVDESSLTGESLPVLKTALP------------------DGDAVFAGTINFGGTL------IVKVTATGIL------- 123
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    259 NTQWVHGIVVYTGHDTKlmqnsTSPPLKLSNVERItnvqILILFCILIAMSLVCSVGSAIWNRRHSGKDwylnlnyggas 338
Cdd:TIGR01494  124 TTVGKIAVVVYTGFSTK-----TPLQSKADKFENF----IFILFLLLLALAVFLLLPIGGWDGNSIYKA----------- 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    339 nfglnFLTFIILFNNLIPISLLVTLEVVKFTQayfinwDLDMHYEPtdtaAMARTSNLNEELGQVKYIFSDKTGTLTCNV 418
Cdd:TIGR01494  184 -----ILRALAVLVIAIPCALPLAVSVALAVG------DARMAKKG----ILVKNLNALEELGKVDVICFDKTGTLTTNK 248
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    419 MQFKKCTIAGVAYGhvpepedygcspdewqnsqfgdektFSDSSLLENLQNNhptapiicefltmmavchtavperegdk 498
Cdd:TIGR01494  249 MTLQKVIIIGGVEE-------------------------ASLALALLAASLE---------------------------- 275
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    499 iiYQAASPDEGALVRAAKQLNFVFTGRtpdsviidslgqeERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVI 578
Cdd:TIGR01494  276 --YLSGHPLERAIVKSAEGVIKSDEIN-------------VEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFV 340
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    579 YDRLAETSKYKEitlkHLEQFATEGLRTLCFAVAEisesdfqewravyqrastsvqnrllkleesyelIEKNLQLLGATA 658
Cdd:TIGR01494  341 LERCNNENDYDE----KVDEYARQGLRVLAFASKK---------------------------------LPDDLEFLGLLT 383
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    659 IEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLlkknmgmivinegsldgtretlsrhcttlgdalrken 738
Cdd:TIGR01494  384 FEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGI------------------------------------- 426
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    739 dfaliidgktlkyaltfgvrqyfldlalsckaVICCRVSPLQKSEVVEMVKKQVKVVTLaIGDGANDVSMIQTAHVGVGI 818
Cdd:TIGR01494  427 --------------------------------DVFARVKPEEKAAIVEALQEKGRTVAM-TGDGVNDAPALKKADVGIAM 473
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17978471    819 SGNEglQAANSSDYSIAQFKYLKNLLMIHGAWN-YNRVSKCILYCFYKNIVLYIIEIWFAFVN 880
Cdd:TIGR01494  474 GSGD--VAKAAADIVLLDDDLSTIVEAVKEGRKtFSNIKKNIFWAIAYNLILIPLALLLIVII 534
PhoLip_ATPase_C pfam16212
Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the ...
827-1079 1.45e-108

Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the C-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 465071 [Multi-domain]  Cd Length: 250  Bit Score: 339.87  E-value: 1.45e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    827 ANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPL 906
Cdd:pfam16212    1 ARASDYAIAQFRFLKRLLLVHGRWSYRRTSKLILYFFYKNIVFTLTQFWYQFYNGFSGQSLYESWYLTLYNLLFTSLPVI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    907 TLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLkALQYGTAFGNGKTSDYLLLGNFVYT 986
Cdd:pfam16212   81 VLGIFDQDVSAETLLAYPELYKLGQKNKFFNLKTFLGWMLDGIYQSLIIFFIPY-LAYGDSVFSGGKDADLWAFGTTVFT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    987 FVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMapDMSGEAAMLFSSGVFWMGLLFIPVASLLLD 1066
Cdd:pfam16212  160 ALVLVVNLKLALETHYWTWITHLAIWGSILLYFLFTLIYSSIYPSSYS--VFYGVASRLFGSPSFWLTLLLIVVVALLPD 237
                          250
                   ....*....|...
gi 17978471   1067 VVYKVIKRTAFKT 1079
Cdd:pfam16212  238 FAYKALKRTFFPT 250
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
544-902 1.01e-45

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 167.63  E-value: 1.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  544 LNVLEFTSARKRMSVIVRTPsGKLRLYCKGADTVIYDR--LAETSKYKEITLKHLEQFATEGLRTLCFAVAEISEsdfqe 621
Cdd:cd01431   22 IEEIPFNSTRKRMSVVVRLP-GRYRAIVKGAPETILSRcsHALTEEDRNKIEKAQEESAREGLRVLALAYREFDP----- 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  622 wravyqrastsvqnrllklEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKL 701
Cdd:cd01431   96 -------------------ETSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  702 LKKNMGMIvinegsldgtretlsrhCTTLGDALRKENDFALIidgktlkyaltfgvrqyfldlalsCKAVICCRVSPLQK 781
Cdd:cd01431  157 DTKASGVI-----------------LGEEADEMSEEELLDLI------------------------AKVAVFARVTPEQK 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  782 SEVVEMVKKQVKVVtLAIGDGANDVSMIQTAHVGVGIsGNEGLQAANSSDYSIAQFKYLKNLLM--IHGAWNYNRVSKCI 859
Cdd:cd01431  196 LRIVKALQARGEVV-AMTGDGVNDAPALKQADVGIAM-GSTGTDVAKEAADIVLLDDNFATIVEavEEGRAIYDNIKKNI 273
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 17978471  860 LYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTA 902
Cdd:cd01431  274 TYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDLIPA 316
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
106-1074 1.51e-42

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 168.75  E-value: 1.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  106 LFILAVAAIKEIIEDIKRHKADNAVN--KK----QTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEpqa 179
Cdd:COG0474   85 IVILAVVLLNAIIGFVQEYRAEKALEalKKllapTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKD--- 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  180 mCYIETSNLDGETnlkirqgLPATsdiKDVDSLmrisgrieceSPNRHLYD-----FVGNIRLDGHGTvplgadqillrg 254
Cdd:COG0474  162 -LQVDESALTGES-------VPVE---KSADPL----------PEDAPLGDrgnmvFMGTLVTSGRGT------------ 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  255 aqlrntqwvhGIVVYTGHDT------KLMQNSTSP--PLKLsNVERITNVqiLILFCILIAMsLVCSVGSAiwnrrhSGK 326
Cdd:COG0474  209 ----------AVVVATGMNTefgkiaKLLQEAEEEktPLQK-QLDRLGKL--LAIIALVLAA-LVFLIGLL------RGG 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  327 DWYLNlnyggasnfglnFLTFIILFNNLIPISLLVtleVVKFTQAyfINwdldmhyeptdTAAMAR----TSNLN--EEL 400
Cdd:COG0474  269 PLLEA------------LLFAVALAVAAIPEGLPA---VVTITLA--LG-----------AQRMAKrnaiVRRLPavETL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  401 GQVKYIFSDKTGTLTCNVMQFKKCTIAGVAY---GHVPEPEDygcspdewqnsqfgdektfsdssllenlqnnhptapii 477
Cdd:COG0474  321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYevtGEFDPALE-------------------------------------- 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  478 cEFLTMMAVCHTAVPERE---GDkiiyqaasPDEGALVRAAKQLNfvftgrtpdsviIDSLGQEERYELLNVLEFTSARK 554
Cdd:COG0474  363 -ELLRAAALCSDAQLEEEtglGD--------PTEGALLVAAAKAG------------LDVEELRKEYPRVDEIPFDSERK 421
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  555 RMSVIVRTPSGKLRLYCKGADTVIYDR----------LAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDfqewra 624
Cdd:COG0474  422 RMSTVHEDPDGKRLLIVKGAPEVVLALctrvltgggvVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPADP------ 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  625 vyqrastsvqnrllklEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckllkK 704
Cdd:COG0474  496 ----------------ELDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIA-------R 552
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  705 NMGMIVINEGSLDGTR-ETLSRHctTLGDALRKENDFAliidgktlkyaltfgvrqyfldlalsckaviccRVSPLQKSE 783
Cdd:COG0474  553 QLGLGDDGDRVLTGAElDAMSDE--ELAEAVEDVDVFA---------------------------------RVSPEHKLR 597
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  784 VVEMVKKQVKVV--TlaiGDGANDVSMIQTAHVGV--GISGNEglqAA-NSSDYSIAQfkylKNLLMIHGAWNYNRVskc 858
Cdd:COG0474  598 IVKALQANGHVVamT---GDGVNDAPALKAADIGIamGITGTD---VAkEAADIVLLD----DNFATIVAAVEEGRR--- 664
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  859 IlycfYKNI---VLYII-----EIWFAFVNGFSG--------QILFerwciglyNVMFTAMPP-LTLGiFERScRKENML 921
Cdd:COG0474  665 I----YDNIrkfIKYLLssnfgEVLSVLLASLLGlplpltpiQILW--------INLVTDGLPaLALG-FEPV-EPDVMK 730
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  922 KYPElyktSQNALDFNTKVFWVHCLNGLFHSVILFWFplkalqYGTAFGNGKTSDY--------LLLGNFVYTFVVitvc 993
Cdd:COG0474  731 RPPR----WPDEPILSRFLLLRILLLGLLIAIFTLLT------FALALARGASLALartmafttLVLSQLFNVFNC---- 796
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  994 lkaglETSYWTWFsHIAIWGSIALWVVFFGIYSSLWpAIPMAPDMSGeaamLFS----SGVFWMGLLFIPVASLLLDVVY 1069
Cdd:COG0474  797 -----RSERRSFF-KSGLFPNRPLLLAVLLSLLLQL-LLIYVPPLQA----LFGtvplPLSDWLLILGLALLYLLLVELV 865

                 ....*
gi 17978471 1070 KVIKR 1074
Cdd:COG0474  866 KLLRR 870
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
128-822 1.76e-34

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 141.96  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  128 NAVNKKQT-QVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEpqamCYIETSNLDGETNLkIRQglpaTSDI 206
Cdd:cd02081   94 NSKKEDQKvTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGND----LKIDESSLTGESDP-IKK----TPDN 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  207 KDVDSLMrISG-RIecespnrhlydfvgnirLDGHGTVplgadqilLRGAQLRNTQWvhGIVVytghdTKLMQNSTSP-P 284
Cdd:cd02081  165 QIPDPFL-LSGtKV-----------------LEGSGKM--------LVTAVGVNSQT--GKIM-----TLLRAENEEKtP 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  285 L--KLSNV-ERITNVQIL---ILFCILIAMSLVcsvgSAIWNRRHSGKDWYLNlnyggasnfglNFLTFIILFNNLIPIS 358
Cdd:cd02081  212 LqeKLTKLaVQIGKVGLIvaaLTFIVLIIRFII----DGFVNDGKSFSAEDLQ-----------EFVNFFIIAVTIIVVA 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  359 ------LLVTLevvkfTQAYFINwdldmhyeptdtaAMARTSNL------NEELGQVKYIFSDKTGTLTCNVMQFKKCTI 426
Cdd:cd02081  277 vpeglpLAVTL-----SLAYSVK-------------KMMKDNNLvrhldaCETMGNATAICSDKTGTLTQNRMTVVQGYI 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  427 AgvayghvpepedygcspdewqnsqfgdektfsdssllenlqnnhptapiicefltmmavchtavperegdkiiyqaaSP 506
Cdd:cd02081  339 G-----------------------------------------------------------------------------NK 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  507 DEGALvraakqLNFVfTGRTPDSVIIDslgQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLA--- 583
Cdd:cd02081  342 TECAL------LGFV-LELGGDYRYRE---KRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSyil 411
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  584 --------ETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRavyqrastsvqnrllKLEESYELIEKNLQLLG 655
Cdd:cd02081  412 nsdgevvfLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPTAE---------------RDWDDEEDIESDLTFIG 476
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  656 ATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVInEGSldgtretlsrhcttlgdalr 735
Cdd:cd02081  477 IVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVL-EGK-------------------- 535
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  736 kenDFALIIDGKTLKyaltfgVRQYFLDLALScKAVICCRVSPLQKSEVVEMVKKQVKVVtlAI-GDGANDVSMIQTAHV 814
Cdd:cd02081  536 ---EFRELIDEEVGE------VCQEKFDKIWP-KLRVLARSSPEDKYTLVKGLKDSGEVV--AVtGDGTNDAPALKKADV 603
                        730
                 ....*....|
gi 17978471  815 G--VGISGNE 822
Cdd:cd02081  604 GfaMGIAGTE 613
PhoLip_ATPase_N pfam16209
Phospholipid-translocating ATPase N-terminal; PhoLip_ATPase_N is found at the N-terminus of a ...
39-102 1.86e-28

Phospholipid-translocating ATPase N-terminal; PhoLip_ATPase_N is found at the N-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 465069 [Multi-domain]  Cd Length: 67  Bit Score: 108.72  E-value: 1.86e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17978471     39 IFINQPQLT---KFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTL 102
Cdd:pfam16209    1 VYINDPEKNsefKYPSNKISTSKYTLLTFLPKNLFEQFRRVANLYFLLIAILQLIPGISPTGPYTTI 67
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
409-827 1.39e-27

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 121.32  E-value: 1.39e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    409 DKTGTLTCNVMQFKkctiaGVayghvpepedYGCSpdewQNSQFGDEKTfsdssllenlqnnHPTAPIICEFLTMMAVCH 488
Cdd:TIGR01657  454 DKTGTLTEDGLDLR-----GV----------QGLS----GNQEFLKIVT-------------EDSSLKPSITHKALATCH 501
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    489 tAVPEREG-------DKIIYQAAspdeGALVRAAKQLNFvftgRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVR 561
Cdd:TIGR01657  502 -SLTKLEGklvgdplDKKMFEAT----GWTLEEDDESAE----PTSILAVVRTDDPPQELSIIRRFQFSSALQRMSVIVS 572
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    562 TPS-GKLRLYCKGADTVIYDRLAET---SKYKEItlkhLEQFATEGLRTLCFAVAEISESDFQEWRAVyqrastsvqnrl 637
Cdd:TIGR01657  573 TNDeRSPDAFVKGAPETIQSLCSPEtvpSDYQEV----LKSYTREGYRVLALAYKELPKLTLQKAQDL------------ 636
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    638 lkleeSYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLL-KKNMGMIVINEGSL 716
Cdd:TIGR01657  637 -----SRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnPSNTLILAEAEPPE 711
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    717 DG-------------------TRETLSRHCTTLGDALRKENDFAliIDGKTLKYALTFgVRQYFLDLALSCKavICCRVS 777
Cdd:TIGR01657  712 SGkpnqikfevidsipfastqVEIPYPLGQDSVEDLLASRYHLA--MSGKAFAVLQAH-SPELLLRLLSHTT--VFARMA 786
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 17978471    778 PLQKSEVVEMVKKqVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAA 827
Cdd:TIGR01657  787 PDQKETLVELLQK-LDYTVGMCGDGANDCGALKQADVGISLSEAEASVAA 835
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
96-822 1.34e-24

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 110.78  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   96 TGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNK---KQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISL 172
Cdd:cd02089   53 LGEYVDAIVIIAIVILNAVLGFVQEYKAEKALAALKKmsaPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLI 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  173 SSSEPQamcyIETSNLDGETNlkirqglPATSDIKDVDSlmrisgriecesPNRHLYD-----FVGNIRLDGHGTvplga 247
Cdd:cd02089  133 ESASLR----VEESSLTGESE-------PVEKDADTLLE------------EDVPLGDrknmvFSGTLVTYGRGR----- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  248 dqillrgaqlrntqwvhGIVVYTGHDTKL-----MQNSTS---PPL--KLSNVERITNVQILILfCILIamslvcsVGSA 317
Cdd:cd02089  185 -----------------AVVTATGMNTEMgkiatLLEETEeekTPLqkRLDQLGKRLAIAALII-CALV-------FALG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  318 IWNrrhsGKDWYLNlnyggasnfglnFLTFIILFNNLIPISLLVtleVVKFTQAYFINWDLDMHyeptdtaAMARTSNLN 397
Cdd:cd02089  240 LLR----GEDLLDM------------LLTAVSLAVAAIPEGLPA---IVTIVLALGVQRMAKRN-------AIIRKLPAV 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  398 EELGQVKYIFSDKTGTLTCNVMqfkkctiagvayghvpepedygcspdewqnsqfgdektfsdssllenlqnnhptapii 477
Cdd:cd02089  294 ETLGSVSVICSDKTGTLTQNKM---------------------------------------------------------- 315
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  478 ceflTMMAVCHTavpereGDkiiyqaasPDEGALVRAAKQLNfvftgrtpdsviIDSLGQEERYELLNVLEFTSARKRMS 557
Cdd:cd02089  316 ----TVEKIYTI------GD--------PTETALIRAARKAG------------LDKEELEKKYPRIAEIPFDSERKLMT 365
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  558 VIVRTPsGKLRLYCKGAdtviYDRLAETSKY--------------KEITLKHLEQFATEGLRTLCFAVAEISESDFQEWr 623
Cdd:cd02089  366 TVHKDA-GKYIVFTKGA----PDVLLPRCTYiyingqvrplteedRAKILAVNEEFSEEALRVLAVAYKPLDEDPTESS- 439
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  624 avyqrastsvqnrllkleesyELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckllk 703
Cdd:cd02089  440 ---------------------EDLENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIA------- 491
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  704 KNMGmiVINEGSLDGTRETLSRhcttLGDAlrkenDFALIIDgKTLKYAltfgvrqyfldlalsckaviccRVSPLQKSE 783
Cdd:cd02089  492 KELG--ILEDGDKALTGEELDK----MSDE-----ELEKKVE-QISVYA----------------------RVSPEHKLR 537
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|.
gi 17978471  784 VVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGV--GISGNE 822
Cdd:cd02089  538 IVKALQRKGKIVAMT-GDGVNDAPALKAADIGVamGITGTD 577
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
398-822 5.13e-21

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 99.67  E-value: 5.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  398 EELGQVKYIFSDKTGTLTCNVMQFKK-CTIAGVayghvpepeDYGCSPDEWQ--NSQFGDE-KTFSDSSLLENLQNnhpt 473
Cdd:cd02083  335 ETLGCTSVICSDKTGTLTTNQMSVSRmFILDKV---------EDDSSLNEFEvtGSTYAPEgEVFKNGKKVKAGQY---- 401
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  474 aPIICEFLTMMAVCHTAVPEREGDKIIYQA-ASPDEGALVRAAKQLNfVFTGRTPDSVIIDSLGQ-----EERYELLNVL 547
Cdd:cd02083  402 -DGLVELATICALCNDSSLDYNESKGVYEKvGEATETALTVLVEKMN-VFNTDKSGLSKRERANAcndviEQLWKKEFTL 479
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  548 EFTSARKRMSVIVR--TPSGKLRLYCKGADTVIYDR-----------LAETSKYKEITLKHLEQFATEGLRTLCFAvaei 614
Cdd:cd02083  480 EFSRDRKSMSVYCSptKASGGNKLFVKGAPEGVLERcthvrvgggkvVPLTAAIKILILKKVWGYGTDTLRCLALA---- 555
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  615 sesdfqewravYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAIN 694
Cdd:cd02083  556 -----------TKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEA 624
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  695 IGhsCKLlkknmgmivineGSLDGTRETLSRHCTTlgdalrKENDfALIIDGKTLkyaltfGVRqyfldlalscKAVICC 774
Cdd:cd02083  625 IC--RRI------------GIFGEDEDTTGKSYTG------REFD-DLSPEEQRE------ACR----------RARLFS 667
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 17978471  775 RVSPLQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGVGI-SGNE 822
Cdd:cd02083  668 RVEPSHKSKIVELLQSQGEITAMT-GDGVNDAPALKKAEIGIAMgSGTA 715
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
409-827 1.20e-20

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 98.09  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  409 DKTGTLTCNVMQFkkctiagvayghvpepedYGCSPDEWQNsqFGDEKTFSDSSLLENLQNNHPtapiiceFLTMMAVCH 488
Cdd:cd07542  311 DKTGTLTEDGLDL------------------WGVRPVSGNN--FGDLEVFSLDLDLDSSLPNGP-------LLRAMATCH 363
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  489 TAvpEREGDKIIyqaASPDEgalvraakQLNFVFTGRTpdsviidslgqeerYELLNVLEFTSARKRMSVIVRTPS-GKL 567
Cdd:cd07542  364 SL--TLIDGELV---GDPLD--------LKMFEFTGWS--------------LEILRQFPFSSALQRMSVIVKTPGdDSM 416
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  568 RLYCKGADTVIYDR-LAET--SKYKEItlkhLEQFATEGLRTLCFAVAEIsESDFQEwravyqrastsvqnrLLKLeeSY 644
Cdd:cd07542  417 MAFTKGAPEMIASLcKPETvpSNFQEV----LNEYTKQGFRVIALAYKAL-ESKTWL---------------LQKL--SR 474
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  645 ELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCkllkknmGMIVINEGSLdgtretLS 724
Cdd:cd07542  475 EEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVAREC-------GMISPSKKVI------LI 541
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  725 RHCTTLGDALRKENDFALIidgktlkyaltfgvrqyfldlalscKAVICCRVSPLQKSEVVEMVKKQVKVVTLAiGDGAN 804
Cdd:cd07542  542 EAVKPEDDDSASLTWTLLL-------------------------KGTVFARMSPDQKSELVEELQKLDYTVGMC-GDGAN 595
                        410       420
                 ....*....|....*....|...
gi 17978471  805 DVSMIQTAHVGVGISGNEGLQAA 827
Cdd:cd07542  596 DCGALKAADVGISLSEAEASVAA 618
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
131-816 2.54e-19

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 93.99  E-value: 2.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  131 NKKQT-QVLRNGAWEIVHWEKVAVGEIVKVT---NGEHLPADLISLSSSepqamCYIETSNLDGETNLKIRQglpatsDI 206
Cdd:cd07543   83 NKPYTiQVYRDGKWVPISSDELLPGDLVSIGrsaEDNLVPCDLLLLRGS-----CIVNEAMLTGESVPLMKE------PI 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  207 KDVDSLmrisGRIECESPNRHLYDFVGNIRL----DGHGTVPLGADQILlrgaqlrntqwvhGIVVYTGHDT---KLMQN 279
Cdd:cd07543  152 EDRDPE----DVLDDDGDDKLHVLFGGTKVVqhtpPGKGGLKPPDGGCL-------------AYVLRTGFETsqgKLLRT 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  280 StspplkLSNVERIT--NVQ--ILILFCI---LIAMSLVCSVGSaiwnrrhsgKDwylnlnygGASNFGLnFLTFIILFN 352
Cdd:cd07543  215 I------LFSTERVTanNLEtfIFILFLLvfaIAAAAYVWIEGT---------KD--------GRSRYKL-FLECTLILT 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  353 NLIPISLLVTLEVVkftqayfINWDLdmhyeptdtAAMARTSNLNEE------LGQVKYIFSDKTGTLTCNVMQFkkcti 426
Cdd:cd07543  271 SVVPPELPMELSLA-------VNTSL---------IALAKLYIFCTEpfripfAGKVDICCFDKTGTLTSDDLVV----- 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  427 AGVAyghvpepedyGCSPDewqnsqfgdektfsDSSLLENLQNNHPTAPIIcefltmmAVCHTAVPEREGDKIiyqaASP 506
Cdd:cd07543  330 EGVA----------GLNDG--------------KEVIPVSSIEPVETILVL-------ASCHSLVKLDDGKLV----GDP 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  507 DEGALVRAAK----QLNFVFtgrtPDSVIIDSLGQEERYEllnvleFTSARKRMSVIVR-----TPSGKLRLYCKGADTV 577
Cdd:cd07543  375 LEKATLEAVDwtltKDEKVF----PRSKKTKGLKIIQRFH------FSSALKRMSVVASykdpgSTDLKYIVAVKGAPET 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  578 IYDRLAETSKYKEITLKhleQFATEGLRTLCFAVAEISESDFQEWRavyqrastsvqnrllklEESYELIEKNLQLLGAT 657
Cdd:cd07543  445 LKSMLSDVPADYDEVYK---EYTRQGSRVLALGYKELGHLTKQQAR-----------------DYKREDVESDLTFAGFI 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  658 AIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKnmgmivinegslDGTRETLSRhcttlgdalrke 737
Cdd:cd07543  505 VFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIVDK------------PVLILILSE------------ 560
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17978471  738 ndfaliiDGKTLKYALTFGVRqyfldlalsckavICCRVSPLQKSEVVEMVkKQVKVVTLAIGDGANDVSMIQTAHVGV 816
Cdd:cd07543  561 -------EGKSNEWKLIPHVK-------------VFARVAPKQKEFIITTL-KELGYVTLMCGDGTNDVGALKHAHVGV 618
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
108-831 9.18e-18

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 89.05  E-value: 9.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  108 ILAVAAIKEIIEDIKRHKADNAVNKKQT------QVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLIslsssepqamc 181
Cdd:cd02086   62 IAAVIALNVIVGFIQEYKAEKTMDSLRNlsspnaHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLR----------- 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  182 YIETSNLDGETNLKIRQGLPAtsdIKDVDSLMrisGRIECESP-NRHLYDFVGNIRLDGHGT---------VPLGADQIL 251
Cdd:cd02086  131 LIETKNFETDEALLTGESLPV---IKDAELVF---GKEEDVSVgDRLNLAYSSSTVTKGRAKgivvatgmnTEIGKIAKA 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  252 LRGA-----QLRNTQWVHGIVVYTGHDTK--LMQNSTSPplklsnVERITNVQILILFCILIAMSLVCSvgsaiwnrrhs 324
Cdd:cd02086  205 LRGKgglisRDRVKSWLYGTLIVTWDAVGrfLGTNVGTP------LQRKLSKLAYLLFFIAVILAIIVF----------- 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  325 gkdwylnlnygGASNFglNFLTFIILFN-----NLIPISLLVTLEVvkfTQAyfinwdldmhyepTDTAAMARTS----N 395
Cdd:cd02086  268 -----------AVNKF--DVDNEVIIYAialaiSMIPESLVAVLTI---TMA-------------VGAKRMVKRNvivrK 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  396 LN--EELGQVKYIFSDKTGTLTCNVMQFKKCtiagvayghvpepedygcspdeWqnsqfgdektfsdssllenlqnnhpt 473
Cdd:cd02086  319 LDalEALGAVTDICSDKTGTLTQGKMVVRQV----------------------W-------------------------- 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  474 apIICefltmmAVCHTAVPEREGDKIIYQA-ASPDEGALVRAAKQLNFvftGRtpDSVIIDSLGQeerYELLNVLEFTSA 552
Cdd:cd02086  351 --IPA------ALCNIATVFKDEETDCWKAhGDPTEIALQVFATKFDM---GK--NALTKGGSAQ---FQHVAEFPFDST 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  553 RKRMSVI-VRTPSGKLRLYCKGADTVIYDRL----------AETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQE 621
Cdd:cd02086  415 VKRMSVVyYNNQAGDYYAYMKGAVERVLECCssmygkdgiiPLDDEFRKTIIKNVESLASQGLRVLAFASRSFTKAQFND 494
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  622 wravyqrastsvqNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckl 701
Cdd:cd02086  495 -------------DQLKNITLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIA----- 556
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  702 lkKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENdfaliIDgktlkyaltfgvrqyfldlALSCKAVICCRVSPLQK 781
Cdd:cd02086  557 --REVGILPPNSYHYSQEIMDSMVMTASQFDGLSDEE-----VD-------------------ALPVLPLVIARCSPQTK 610
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|
gi 17978471  782 SEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGVGISGNEGLQAANSSD 831
Cdd:cd02086  611 VRMIEALHRRKKFCAMT-GDGVNDSPSLKMADVGIAMGLNGSDVAKDASD 659
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
108-910 1.37e-17

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 88.92  E-value: 1.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    108 ILAVAAIKEIIEDIKRHKADNAVNKKQT------QVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLIslsssepqamc 181
Cdd:TIGR01523   87 ISAIIALNILIGFIQEYKAEKTMDSLKNlaspmaHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLR----------- 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    182 YIETSNLDGETNLKIRQGLPATSDIKDV-----------------DSLMRISGRIECESPNRHLYDFVGNIR--LDGHGT 242
Cdd:TIGR01523  156 LIETKNFDTDEALLTGESLPVIKDAHATfgkeedtpigdrinlafSSSAVTKGRAKGICIATALNSEIGAIAagLQGDGG 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    243 VPLGADQILLRGAQLRNTQWVHGIVVYTGhdtKLMQNSTSPPLklsnvERITNVQILILFCILIAMSLVCSVGSAIwnrr 322
Cdd:TIGR01523  236 LFQRPEKDDPNKRRKLNKWILKVTKKVTG---AFLGLNVGTPL-----HRKLSKLAVILFCIAIIFAIIVMAAHKF---- 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    323 HSGKDWYLnlnYGgasnfglnfltfIILFNNLIPISLLVTLEVVKFTQAYFInwdldmhyepTDTAAMARTSNLNEELGQ 402
Cdd:TIGR01523  304 DVDKEVAI---YA------------ICLAISIIPESLIAVLSITMAMGAANM----------SKRNVIVRKLDALEALGA 358
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    403 VKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPED------------YGCSPDEWQNSQFGDE---KTFSDSSLLENL 467
Cdd:TIGR01523  359 VNDICSDKTGTITQGKMIARQIWIPRFGTISIDNSDDafnpnegnvsgiPRFSPYEYSHNEAADQdilKEFKDELKEIDL 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    468 QNNHPTAPIIcEFLTMMAVCHTAVPEREGDKIIYQA-ASPDEGALVRAAKQLNFVFTGRT-------PDSVIIDSLGQEE 539
Cdd:TIGR01523  439 PEDIDMDLFI-KLLETAALANIATVFKDDATDCWKAhGDPTEIAIHVFAKKFDLPHNALTgeedllkSNENDQSSLSQHN 517
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    540 ------RYELLNVLEFTSARKRMSVIVRTPSGKL-RLYCKGADTVIYDRLAE------------TSKYKEITLKHLEQFA 600
Cdd:TIGR01523  518 ekpgsaQFEFIAEFPFDSEIKRMASIYEDNHGETyNIYAKGAFERIIECCSSsngkdgvkisplEDCDRELIIANMESLA 597
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    601 TEGLRTLCFAVAEISESDfqewravyqrastsVQNRLLKLEES-YELIEKNLQLLGATAIEDKLQDQVPETIETLMKADI 679
Cdd:TIGR01523  598 AEGLRVLAFASKSFDKAD--------------NNDDQLKNETLnRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGI 663
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    680 KIWILTGDKQETAINIGHSCKLLKKNmgMIVINEGSLDGTRETLSRHcttlgDALRKENdfaliIDgktlkyaltfgvrq 759
Cdd:TIGR01523  664 NVHMLTGDFPETAKAIAQEVGIIPPN--FIHDRDEIMDSMVMTGSQF-----DALSDEE-----VD-------------- 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    760 yflDLALSCkaVICCRVSPLQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKY 839
Cdd:TIGR01523  718 ---DLKALC--LVIARCAPQTKVKMIEALHRRKAFCAMT-GDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNF 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    840 LKNLLMI-HGAWNYNRVSKCILYCFYKNI---VLYIIEIWFAFVNGFS------GQILferWCiglyNVMFTAMPPLTLG 909
Cdd:TIGR01523  792 ASILNAIeEGRRMFDNIMKFVLHLLAENVaeaILLIIGLAFRDENGKSvfplspVEIL---WC----IMITSCFPAMGLG 864

                   .
gi 17978471    910 I 910
Cdd:TIGR01523  865 L 865
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
485-581 1.67e-17

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 78.41  E-value: 1.67e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    485 AVCHTAVPEREGDKIIYQAA-SPDEGALVRAAKQLNfvftgrtpdsviIDSLGQEERYELLNVLEFTSARKRMSVIVRTP 563
Cdd:pfam13246    1 ALCNSAAFDENEEKGKWEIVgDPTESALLVFAEKMG------------IDVEELRKDYPRVAEIPFNSDRKRMSTVHKLP 68
                           90
                   ....*....|....*....
gi 17978471    564 -SGKLRLYCKGADTVIYDR 581
Cdd:pfam13246   69 dDGKYRLFVKGAPEIILDR 87
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
401-878 1.85e-17

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 88.03  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  401 GQVKYIFSDKTGTLTcnvmqfkkctiagvayghvpepEDygcSPDEWQNSQFGDEKTFSDsslLENLQNNHPTapiicEF 480
Cdd:cd02082  301 GRIQTLCFDKTGTLT----------------------ED---KLDLIGYQLKGQNQTFDP---IQCQDPNNIS-----IE 347
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  481 LTMMAVCHTavperegdkiiyqaASPDEGALV---RAAKQLNFVFTGRTPDSVIID--SLGQEERYELLNVLEFTSARKR 555
Cdd:cd02082  348 HKLFAICHS--------------LTKINGKLLgdpLDVKMAEASTWDLDYDHEAKQhySKSGTKRFYIIQVFQFHSALQR 413
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  556 MSVIVR-----TPSGKLRLYCKGADTVIYDrLAET--SKYKEItlkhLEQFATEGLRTLCFAVAEISESDFQEwravyqr 628
Cdd:cd02082  414 MSVVAKevdmiTKDFKHYAFIKGAPEKIQS-LFSHvpSDEKAQ----LSTLINEGYRVLALGYKELPQSEIDA------- 481
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  629 astsvqnrllKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGM 708
Cdd:cd02082  482 ----------FLDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKNPT 551
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  709 IVInegsldgtretlsrHCTTLGDALRKENDFALIIDGKTLkyaltfgvrqyfldlalsckavicCRVSPLQKSEVVEMV 788
Cdd:cd02082  552 III--------------HLLIPEIQKDNSTQWILIIHTNVF------------------------ARTAPEQKQTIIRLL 593
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  789 kKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGlQAANSSDYSIAQFKYLKNLLMihgawnYNRVSKCILYCFYKNIV 868
Cdd:cd02082  594 -KESDYIVCMCGDGANDCGALKEADVGISLAEADA-SFASPFTSKSTSISCVKRVIL------EGRVNLSTSVEIFKGYA 665
                        490
                 ....*....|
gi 17978471  869 LYIIEIWFAF 878
Cdd:cd02082  666 LVALIRYLSF 675
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
108-822 5.40e-16

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 83.47  E-value: 5.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  108 ILAVAAIKEIIEDIKRHKADNAVNKKQ------TQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQamc 181
Cdd:cd02080   62 IFGVVLINAIIGYIQEGKAEKALAAIKnmlspeATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQ--- 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  182 yIETSNLDGETNL--KIRQGLPATSDIKDVDSLMrisgriecespnrhlydFVGNIRLDGHGTvplgadqillrgaqlrn 259
Cdd:cd02080  139 -IDESALTGESVPveKQEGPLEEDTPLGDRKNMA-----------------YSGTLVTAGSAT----------------- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  260 tqwvhGIVVYTGHDT------KLMQN--STSPPLklsnVERITNVQILILFCILIAMSLVCSVGsaiWNRRHSgkdwyln 331
Cdd:cd02080  184 -----GVVVATGADTeigrinQLLAEveQLATPL----TRQIAKFSKALLIVILVLAALTFVFG---LLRGDY------- 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  332 lnyggasNFGLNFLTFIILFNNLIPISLLVTLEVVkftqayfinwdLDMhyeptDTAAMAR----TSNLN--EELGQVKY 405
Cdd:cd02080  245 -------SLVELFMAVVALAVAAIPEGLPAVITIT-----------LAI-----GVQRMAKrnaiIRRLPavETLGSVTV 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  406 IFSDKTGTLTCNVMqfkkcTIAGVayghvpepedygcspdeWQNSQfgdektfsDSSLLENlqNNHPTApiicefltmma 485
Cdd:cd02080  302 ICSDKTGTLTRNEM-----TVQAI-----------------VTLCN--------DAQLHQE--DGHWKI----------- 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  486 vchtavperEGDkiiyqaasPDEGALVRAAKQLNfvftgrtpdsviIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSG 565
Cdd:cd02080  339 ---------TGD--------PTEGALLVLAAKAG------------LDPDRLASSYPRVDKIPFDSAYRYMATLHRDDGQ 389
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  566 KLrLYCKGADTVIYDRLAETSKY-------KEITLKHLEQFATEGLRTLCFAVAEISESdfqewravyqrastsvqnrll 638
Cdd:cd02080  390 RV-IYVKGAPERLLDMCDQELLDggvspldRAYWEAEAEDLAKQGLRVLAFAYREVDSE--------------------- 447
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  639 KLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckllkKNMGmIVINEGSLDG 718
Cdd:cd02080  448 VEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIG-------AQLG-LGDGKKVLTG 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  719 TR-ETLSRhcTTLGDALRKENDFAliidgktlkyaltfgvrqyfldlalsckaviccRVSPLQKSEVVEMVKKQVKVVTL 797
Cdd:cd02080  520 AElDALDD--EELAEAVDEVDVFA---------------------------------RTSPEHKLRLVRALQARGEVVAM 564
                        730       740
                 ....*....|....*....|....*..
gi 17978471  798 AiGDGANDVSMIQTAHVGV--GISGNE 822
Cdd:cd02080  565 T-GDGVNDAPALKQADIGIamGIKGTE 590
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
509-831 1.46e-15

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 81.69  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  509 GALVRAAKQLNFVftGRTpDSVIIDSLG--QEERYELLNV------LEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYD 580
Cdd:cd07539  284 GVLVRSPRTVEAL--GRV-DTICFDKTGtlTENRLRVVQVrpplaeLPFESSRGYAAAIGRTGGGIPLLAVKGAPEVVLP 360
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  581 R----------LAETSKYKEITLKHLEQFATEGLRTLCFAvaeisesdfqewravYQRASTSVQNRLlkleesyELIEKN 650
Cdd:cd07539  361 RcdrrmtggqvVPLTEADRQAIEEVNELLAGQGLRVLAVA---------------YRTLDAGTTHAV-------EAVVDD 418
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  651 LQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckllkKNMGMivinegsldgtretlsrhcttl 730
Cdd:cd07539  419 LELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIA-------KELGL---------------------- 469
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  731 gdalrkeNDFALIIDGKTL----KYALTFGVRQyfldlalsckAVICCRVSPLQKSEVVEMVKKQVKVVTLaIGDGANDV 806
Cdd:cd07539  470 -------PRDAEVVTGAELdaldEEALTGLVAD----------IDVFARVSPEQKLQIVQALQAAGRVVAM-TGDGANDA 531
                        330       340
                 ....*....|....*....|....*
gi 17978471  807 SMIQTAHVGVGISGNEGLQAANSSD 831
Cdd:cd07539  532 AAIRAADVGIGVGARGSDAAREAAD 556
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
528-820 1.50e-15

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 81.91  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  528 DSVIIDS------LGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGA--------DTVIYDRLAE--TSKYKEI 591
Cdd:cd02077  358 DKAIIDHaeeanaNGLIQDYTKIDEIPFDFERRRMSVVVKDNDGKHLLITKGAveeilnvcTHVEVNGEVVplTDTLREK 437
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  592 TLKHLEQFATEGLRTLCFAVAEISESDFQewravYQRAStsvqnrllkleesyeliEKNLQLLGATAIEDKLQDQVPETI 671
Cdd:cd02077  438 ILAQVEELNREGLRVLAIAYKKLPAPEGE-----YSVKD-----------------EKELILIGFLAFLDPPKESAAQAI 495
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  672 ETLMKADIKIWILTGDKQETAINIghsCkllkKNMGMIVinEGSLDGTR-ETLSRhcTTLGDALRKENDFAliidgktlk 750
Cdd:cd02077  496 KALKKNGVNVKILTGDNEIVTKAI---C----KQVGLDI--NRVLTGSEiEALSD--EELAKIVEETNIFA--------- 555
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  751 yaltfgvrqyfldlalsckaviccRVSPLQKSEVVEMVKKQVKVVTLaIGDGANDVSMIQTAHVGVGISG 820
Cdd:cd02077  556 ------------------------KLSPLQKARIIQALKKNGHVVGF-MGDGINDAPALRQADVGISVDS 600
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
137-820 3.76e-15

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 80.52  E-value: 3.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  137 VLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQamcyIETSNLDGETN--LKIRQGLPATSdIKDVDSLMR 214
Cdd:cd02085   88 CLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS----IDESSLTGETEpcSKTTEVIPKAS-NGDLTTRSN 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  215 ISgriecespnrhlydFVGNIRLDGHGtvplgadqillrgaqlrntqwvHGIVVYTGHDT------KLMQNSTSP--PLK 286
Cdd:cd02085  163 IA--------------FMGTLVRCGHG----------------------KGIVIGTGENSefgevfKMMQAEEAPktPLQ 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  287 LSnVERITNVQILILFCILiamSLVCSVGsaiWNRrhsGKDWYLNLNYG-----GASNFGLnfltfiilfnnliPISLLV 361
Cdd:cd02085  207 KS-MDKLGKQLSLYSFIII---GVIMLIG---WLQ---GKNLLEMFTIGvslavAAIPEGL-------------PIVVTV 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  362 TLEVVKFTQAyfinwdldmhyeptDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMqfkkcTIAGVAYGhvpepedyg 441
Cdd:cd02085  264 TLALGVMRMA--------------KRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEM-----TVTKIVTG--------- 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  442 cspdewqnsqfgdektfsdsslleNLQNNhptapiicefltmmAVCHTAVPeregdkiiyqAASPDEGALVRAAKQLNFV 521
Cdd:cd02085  316 ------------------------CVCNN--------------AVIRNNTL----------MGQPTEGALIALAMKMGLS 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  522 ftgrtpdsviidslGQEERYELLNVLEFTSARKRMSVIVRTPSGKLR---LYCKGADTVIYDRLAETSKYKEITLKHLEQ 598
Cdd:cd02085  348 --------------DIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLTQQ 413
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  599 -----------FATEGLRTLCFAVAEISEsdfqewravyqrastsvqnrllkleesyeliekNLQLLGATAIEDKLQDQV 667
Cdd:cd02085  414 qrseineeekeMGSKGLRVLALASGPELG---------------------------------DLTFLGLVGINDPPRPGV 460
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  668 PETIETLMKADIKIWILTGDKQETAINIGhsckllkKNMGMIVINEGSLDGTR-ETLSRHctTLGDALRKENDFAliidg 746
Cdd:cd02085  461 REAIQILLESGVRVKMITGDAQETAIAIG-------SSLGLYSPSLQALSGEEvDQMSDS--QLASVVRKVTVFY----- 526
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17978471  747 ktlkyaltfgvrqyfldlalsckaviccRVSPLQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGV--GISG 820
Cdd:cd02085  527 ----------------------------RASPRHKLKIVKALQKSGAVVAMT-GDGVNDAVALKSADIGIamGRTG 573
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
133-828 5.63e-09

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 60.58  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    133 KQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEpqamCYIETSNLDGETNLKIRqglpatsdikdvdsl 212
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQG----CKVDNSSLTGESEPQTR--------------- 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    213 mriSGRIECESP--NRHLYDFVGNIRldgHGTvplgadqillrgaqlrntqwVHGIVVYTGHDTKL---------MQNST 281
Cdd:TIGR01106  202 ---SPEFTHENPleTRNIAFFSTNCV---EGT--------------------ARGIVVNTGDRTVMgriaslasgLENGK 255
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    282 SP-PLKLSN-VERITNVQIL--ILFCIlIAMSLVCSVGSAIWnrrhsgkdwylnlnyggasnfglnFLTFIILFNnlIPI 357
Cdd:TIGR01106  256 TPiAIEIEHfIHIITGVAVFlgVSFFI-LSLILGYTWLEAVI------------------------FLIGIIVAN--VPE 308
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    358 SLLVTLEVVKftqayfinwdldmhyepTDTAA-MARTS----NLN--EELGQVKYIFSDKTGTLTCNVMqfkkcTIAgva 430
Cdd:TIGR01106  309 GLLATVTVCL-----------------TLTAKrMARKNclvkNLEavETLGSTSTICSDKTGTLTQNRM-----TVA--- 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    431 ygHVpepedygcspdeWQNSQFGDEKTFSDSSLLENLQNNhPTAPIICEFLTMmavCHTAV--PEREGDKIIYQAASPD- 507
Cdd:TIGR01106  364 --HM------------WFDNQIHEADTTEDQSGVSFDKSS-ATWLALSRIAGL---CNRAVfkAGQENVPILKRAVAGDa 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    508 -EGALvraakqLNFVftgrtpDSVIIDSLGQEERYELLNVLEFTSARK-RMSVIVRTPSGKLR--LYCKGADTVIYDRLA 583
Cdd:TIGR01106  426 sESAL------LKCI------ELCLGSVMEMRERNPKVVEIPFNSTNKyQLSIHENEDPRDPRhlLVMKGAPERILERCS 493
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    584 ETS-KYKEITLKH--LEQFATE-------GLRTLCFAVAEISESDFQEWRAVyqraSTSVQNRLLkleesyelieKNLQL 653
Cdd:TIGR01106  494 SILiHGKEQPLDEelKEAFQNAylelgglGERVLGFCHLYLPDEQFPEGFQF----DTDDVNFPT----------DNLCF 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    654 LGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAinighscKLLKKNMGmiVINEGSldGTRETLSRHCTTLGDA 733
Cdd:TIGR01106  560 VGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITA-------KAIAKGVG--IISEGN--ETVEDIAARLNIPVSQ 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471    734 LRKENDFALIIDGKTLKyaltfGVRQYFLDLALSCKA-VICCRVSPLQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTA 812
Cdd:TIGR01106  629 VNPRDAKACVVHGSDLK-----DMTSEQLDEILKYHTeIVFARTSPQQKLIIVEGCQRQGAIVAVT-GDGVNDSPALKKA 702
                          730
                   ....*....|....*....
gi 17978471    813 HVGV--GISGNE-GLQAAN 828
Cdd:TIGR01106  703 DIGVamGIAGSDvSKQAAD 721
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
46-820 1.67e-08

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 58.78  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   46 LTKFCNNHVSTAKYN-IITFLPRFLysqfrrAANSFFLFIALLQQIPDvsptGRYTTLVPLLFILAVAAIKEIIEDIKRH 124
Cdd:cd02076   11 LKEYGPNELPEKKENpILKFLSFFW------GPIPWMLEAAAILAAAL----GDWVDFAIILLLLLINAGIGFIEERQAG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  125 KADNAVNKK---QTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQamcyIETSNLDGETnlkirqgLP 201
Cdd:cd02076   81 NAVAALKKSlapKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQ----VDQSALTGES-------LP 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  202 ATSDIKDVdslmrisgriecespnrhlyDFVGNIRLDGHGTvplgadqillrgaqlrntqwvhGIVVYTGHDT------K 275
Cdd:cd02076  150 VTKHPGDE--------------------AYSGSIVKQGEML----------------------AVVTATGSNTffgktaA 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  276 LMQNSTSPplklSNVERITNvQILILFCILIAMSLVCSVGSAiwnrrhsgkdWYLNLNYGgasnFGLNFLtfIILFNNLI 355
Cdd:cd02076  188 LVASAEEQ----GHLQKVLN-KIGNFLILLALILVLIIVIVA----------LYRHDPFL----EILQFV--LVLLIASI 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  356 PISLLVTLEVvkfTQAyfinwdLDMHYEPTDTAAMARTSNLnEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGvayghvp 435
Cdd:cd02076  247 PVAMPAVLTV---TMA------VGALELAKKKAIVSRLSAI-EELAGVDILCSDKTGTLTLNKLSLDEPYSLE------- 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  436 epedyGCSPDEwqnsqfgdektfsdssllenlqnnhptapiicefltMMAVCHTAVPEREGDKIiyqaaspdEGALVRAA 515
Cdd:cd02076  310 -----GDGKDE------------------------------------LLLLAALASDTENPDAI--------DTAILNAL 340
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  516 KqlnfvftgrtpdsviiDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKH 595
Cdd:cd02076  341 D----------------DYKPDLAGYKQLKFTPFDPVDKRTEATVEDPDGERFKVTKGAPQVILELVGNDEAIRQAVEEK 404
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  596 LEQFATEGLRTLCFAVAEisesDFQEWRavyqrastsvqnrllkleesyelieknlqLLGATAIEDKLQDQVPETIETLM 675
Cdd:cd02076  405 IDELASRGYRSLGVARKE----DGGRWE-----------------------------LLGLLPLFDPPRPDSKATIARAK 451
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  676 KADIKIWILTGDKQETAINIGHsckllKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFAliidgktlkyaltf 755
Cdd:cd02076  452 ELGVRVKMITGDQLAIAKETAR-----QLGMGTNILSAERLKLGGGGGGMPGSELIEFIEDADGFA-------------- 512
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17978471  756 gvrqyfldlalsckaviccRVSPLQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGVGISG 820
Cdd:cd02076  513 -------------------EVFPEHKYRIVEALQQRGHLVGMT-GDGVNDAPALKKADVGIAVSG 557
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
539-820 1.22e-07

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 55.91  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  539 ERYELLNVLEFTSARKRMSVIVRTPSGKLrLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESD 618
Cdd:cd07538  318 ELTSLVREYPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLCRLNPDEKAAIEDAVSEMAGEGLRVLAVAACRIDESF 396
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  619 FQEwravyqrastsvqnrllkleesyELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHS 698
Cdd:cd07538  397 LPD-----------------------DLEDAVFIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQ 453
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  699 CKlLKKNMGMIVINEGSLDGTRETLSRhcttlgdaLRKENDFAliidgktlkyaltfgvrqyfldlalsckaviccRVSP 778
Cdd:cd07538  454 IG-LDNTDNVITGQELDAMSDEELAEK--------VRDVNIFA---------------------------------RVVP 491
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 17978471  779 LQKSEVVEMVKKQVKVVTLAiGDGANDVSMIQTAHVGVGISG 820
Cdd:cd07538  492 EQKLRIVQAFKANGEIVAMT-GDGVNDAPALKAAHIGIAMGK 532
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
78-842 7.28e-06

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 50.36  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   78 NSFFLFIALLqqipdVSPTGRYTTLVPLLFILAVAAIKeIIEDIK-RHKAD--NAVNKKQTQVLRNGAWEIVHWEKVAVG 154
Cdd:cd02609   40 NLINFVIAVL-----LILVGSYSNLAFLGVIIVNTVIG-IVQEIRaKRQLDklSILNAPKVTVIRDGQEVKIPPEELVLD 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  155 EIVKVTNGEHLPADLISLSSSEPQamcyIETSNLDGEtnlkirqglpatSD--IKDVDSLMrISGriecespnrhlyDFV 232
Cdd:cd02609  114 DILILKPGEQIPADGEVVEGGGLE----VDESLLTGE------------SDliPKKAGDKL-LSG------------SFV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  233 gnirLDGHGTVplgadqillrgaqlrntqwvhgIVVYTGHDT---KLMQNSTSPPLKLSNVERITNVQILILFCILIAMS 309
Cdd:cd02609  165 ----VSGAAYA----------------------RVTAVGAESyaaKLTLEAKKHKLINSELLNSINKILKFTSFIIIPLG 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  310 LVCSVgSAIWnRRHSGkdWYLNLNYGGASNFGlnfltfiilfnnLIPISlLVTLEVVKFTqayfinwdldmhyeptdTAA 389
Cdd:cd02609  219 LLLFV-EALF-RRGGG--WRQAVVSTVAALLG------------MIPEG-LVLLTSVALA-----------------VGA 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  390 M--AR----TSNLN--EELGQVKYIFSDKTGTLTCNVMQFKKCTIAgvayghvpepedygcspdewqNSQFGDEKTFSDS 461
Cdd:cd02609  265 IrlAKkkvlVQELYsiETLARVDVLCLDKTGTITEGKMKVERVEPL---------------------DEANEAEAAAALA 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  462 SLLENLQNNHPTAPIICEFLtmmavchtavperEGDKiiyqaaspdegalvraakqlnfvftgrtpdsviidslgqeeRY 541
Cdd:cd02609  324 AFVAASEDNNATMQAIRAAF-------------FGNN-----------------------------------------RF 349
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  542 ELLNVLEFTSARKRMSVIVRtpsgKLRLYCKGADTVIYDRLaetskYKEItLKHLEQFATEGLRTLCFAvaeISESDFQE 621
Cdd:cd02609  350 EVTSIIPFSSARKWSAVEFR----DGGTWVLGAPEVLLGDL-----PSEV-LSRVNELAAQGYRVLLLA---RSAGALTH 416
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  622 wravyqrastsvqnrllkleesyELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGhsckl 701
Cdd:cd02609  417 -----------------------EQLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIA----- 468
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  702 lkKNMGmivinegsLDGTRETLsrhcttlgDALRKENDFALIidgKTLKYALTFGvrqyfldlalsckaviccRVSPLQK 781
Cdd:cd02609  469 --KRAG--------LEGAESYI--------DASTLTTDEELA---EAVENYTVFG------------------RVTPEQK 509
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17978471  782 SEVVEMVKKQVKVVTLaIGDGANDVSMIQTAHVGVGISgnEGLQAANssdySIAQFKYLKN 842
Cdd:cd02609  510 RQLVQALQALGHTVAM-TGDGVNDVLALKEADCSIAMA--SGSDATR----QVAQVVLLDS 563
E1-E2_ATPase pfam00122
E1-E2 ATPase;
135-191 2.58e-05

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 46.03  E-value: 2.58e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 17978471    135 TQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSepqamCYIETSNLDGE 191
Cdd:pfam00122    7 ATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGS-----ASVDESLLTGE 58
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
652-695 3.66e-05

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 47.86  E-value: 3.66e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17978471  652 QLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINI 695
Cdd:cd02094  458 ELAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAI 501
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
134-828 6.85e-05

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 47.34  E-value: 6.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  134 QTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEpqamCYIETSNLDGETNLKIRQglpatsdikdvdslm 213
Cdd:cd02608  107 QALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHG----CKVDNSSLTGESEPQTRS--------------- 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  214 risgrIECESPN----RHLYDFVGNIrLDGHGTvplgadqillrgaqlrntqwvhGIVVYTGHDTKL---------MQNS 280
Cdd:cd02608  168 -----PEFTHENpletKNIAFFSTNC-VEGTAR----------------------GIVINTGDRTVMgriatlasgLEVG 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  281 TSPPLKLSN--VERITNVQIL--ILFCIlIAMSLvcsvgsaiwnrrhsgkdwylnlnyggasnfGLNFLTFIILFNNLI- 355
Cdd:cd02608  220 KTPIAREIEhfIHIITGVAVFlgVSFFI-LSLIL------------------------------GYTWLEAVIFLIGIIv 268
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  356 ---PISLLVTLEVVKftqayfinwdldmhyepTDTAA-MARTS----NLN--EELGQVKYIFSDKTGTLTCNVMqfkkcT 425
Cdd:cd02608  269 anvPEGLLATVTVCL-----------------TLTAKrMARKNclvkNLEavETLGSTSTICSDKTGTLTQNRM-----T 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  426 IAGVAY-GHVPEPEdygCSPDEWQNSQFGDEKTFSDSSLLENLQNNhptapiiCEFLTMMAvcHTAVPERE--GDkiiyq 502
Cdd:cd02608  327 VAHMWFdNQIHEAD---TTEDQSGASFDKSSATWLALSRIAGLCNR-------AEFKAGQE--NVPILKRDvnGD----- 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  503 aASpdEGALVRaakqlnfvFTGRTPDSVIidslGQEERYELLNVLEFTSARK-RMSVIVRTPSGKLR--LYCKGADTVIY 579
Cdd:cd02608  390 -AS--ESALLK--------CIELSCGSVM----EMRERNPKVAEIPFNSTNKyQLSIHENEDPGDPRylLVMKGAPERIL 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  580 DRlaeTSKY----KEITLKhlEQFATE-----------GLRTLCFAVAEISESDFQEWRAVyqraSTSVQNRLLkleesy 644
Cdd:cd02608  455 DR---CSTIlingKEQPLD--EEMKEAfqnaylelgglGERVLGFCHLYLPDDKFPEGFKF----DTDEVNFPT------ 519
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  645 elieKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAinighscKLLKKNMGMIVinegsldgtretls 724
Cdd:cd02608  520 ----ENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITA-------KAIAKGVGIIV-------------- 574
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  725 rhcttlgdalrkendFAliidgktlkyaltfgvrqyfldlalsckaviccRVSPLQKSEVVEMVKKQVKVVTLAiGDGAN 804
Cdd:cd02608  575 ---------------FA---------------------------------RTSPQQKLIIVEGCQRQGAIVAVT-GDGVN 605
                        730       740
                 ....*....|....*....|....*..
gi 17978471  805 DVSMIQTAHVGV--GISGNE-GLQAAN 828
Cdd:cd02608  606 DSPALKKADIGVamGIAGSDvSKQAAD 632
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
652-820 1.49e-04

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 45.90  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  652 QLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAinighsckllkknmgmivinegsldgtretlsrhcttlg 731
Cdd:COG2217  531 RLLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTA--------------------------------------- 571
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  732 DALRKEndfaliidgktlkyaltFGVRQYFLDlalsckaviccrVSPLQKSEVVEMVKKQVKVVtLAIGDGANDVSMIQT 811
Cdd:COG2217  572 EAVARE-----------------LGIDEVRAE------------VLPEDKAAAVRELQAQGKKV-AMVGDGINDAPALAA 621

                 ....*....
gi 17978471  812 AHVGVGISG 820
Cdd:COG2217  622 ADVGIAMGS 630
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
796-846 1.83e-04

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 44.27  E-value: 1.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 17978471    796 TLAIGDGANDVSMIQTAHVGVGISGNEGLQAAnsSDYSIaQFKYLKNLLMI 846
Cdd:TIGR00338  171 TVAVGDGANDLSMIKAAGLGIAFNAKPKLQQK--ADICI-NKKDLTDILPL 218
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
99-191 2.76e-04

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 44.90  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471   99 YTTLVPLLFILAVAaikEIIEDIKRHKADNAVNK------KQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISL 172
Cdd:cd02079   88 FEEAAMLLFLFLLG---RYLEERARSRARSALKAllslapETATVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVV 164
                         90
                 ....*....|....*....
gi 17978471  173 SSSepqamCYIETSNLDGE 191
Cdd:cd02079  165 SGE-----SSVDESSLTGE 178
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
646-697 2.81e-04

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 44.90  E-value: 2.81e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17978471  646 LIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGH 697
Cdd:cd02079  432 YVGRDGKLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAK 483
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
105-168 7.31e-04

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 43.59  E-value: 7.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17978471  105 LLFILAVAaikEIIEDIKRHKADNAVNK------KQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPAD 168
Cdd:COG2217  182 IIFLLLLG---RYLEARAKGRARAAIRAllslqpKTARVLRDGEEVEVPVEELRVGDRVLVRPGERIPVD 248
HAD_PSP cd07500
phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces ...
796-817 1.06e-03

phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p; This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319803 [Multi-domain]  Cd Length: 180  Bit Score: 41.38  E-value: 1.06e-03
                         10        20
                 ....*....|....*....|..
gi 17978471  796 TLAIGDGANDVSMIQTAHVGVG 817
Cdd:cd07500  156 TVAVGDGANDLPMLKAAGLGIA 177
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
786-828 1.23e-03

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 443263 [Multi-domain]  Cd Length: 156  Bit Score: 40.53  E-value: 1.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 17978471  786 EMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEG-----LQAAN 828
Cdd:COG4087   84 EFVEKLGAETTVAIGNGRNDVLMLKEAALGIAVIGPEGasvkaLLAAD 131
YedP COG3769
Mannosyl-3-phosphoglycerate phosphatase YedP/MpgP, HAD superfamily [Carbohydrate transport and ...
791-823 1.93e-03

Mannosyl-3-phosphoglycerate phosphatase YedP/MpgP, HAD superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 442983 [Multi-domain]  Cd Length: 268  Bit Score: 41.35  E-value: 1.93e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 17978471  791 QVKVVTLAIGDGANDVSMIQTAHVGVGISGNEG 823
Cdd:COG3769  205 GKNVVTIALGDSPNDIPMLEAADIAVVIRSPHG 237
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
796-816 7.99e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 38.96  E-value: 7.99e-03
                         10        20
                 ....*....|....*....|.
gi 17978471  796 TLAIGDGANDVSMIQTAHVGV 816
Cdd:COG0561  140 VIAFGDSGNDLEMLEAAGLGV 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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