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Conserved domains on  [gi|1797152346|ref|WP_159115670|]
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aldo/keto reductase [Clostridium neonatale]

Protein Classification

aldo/keto reductase( domain architecture ID 14442380)

aldo/keto reductase is a soluble NAD(P)(H) oxidoreductase that catalyzes the reduction of aldehydes and ketones to their corresponding primary and secondary alcohols, similar to Escherichia coli YajO, which functions as a 1-deoxyxylulose-5-phosphate synthase catalyzing the conversion of ribulose 5-phosphate (Ru5P) to 1-deoxy-D-xylulose 5-phosphate

EC:  1.1.1.-
Gene Ontology:  GO:0016491

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
2-312 6.15e-167

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


:

Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 466.68  E-value: 6.15e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCMGFGEAQKGmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKRE 81
Cdd:cd19079     1 EYVRLGNSGLKVSRLCLGCMSFGDPKWR--PWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC 161
Cdd:cd19079    79 EVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 162 YAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSED-IYAKG 240
Cdd:cd19079   159 YAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTtDTAKL 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 241 KYDITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19079   239 KYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKpgVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
 
Name Accession Description Interval E-value
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
2-312 6.15e-167

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 466.68  E-value: 6.15e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCMGFGEAQKGmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKRE 81
Cdd:cd19079     1 EYVRLGNSGLKVSRLCLGCMSFGDPKWR--PWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC 161
Cdd:cd19079    79 EVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 162 YAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSED-IYAKG 240
Cdd:cd19079   159 YAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTtDTAKL 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 241 KYDITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19079   239 KYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKpgVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
1-319 1.29e-120

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 349.48  E-value: 1.29e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEAQkgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKR 80
Cdd:COG0667     1 MEYRRLGRSGLKVSRLGLGTMTFGGPW-----GGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGR-PR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKF-IPRTQEEIEQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:COG0667    75 DDVVIATKVgRRMGPGPNGRGLSRE-HIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIakAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA-----KHPGEESKRLSE 234
Cdd:COG0667   154 NYSAEQLRRALAI--AEGLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTgkyrrGATFPEGDRAAT 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 235 DIYAKGKYdithDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:COG0667   232 NFVQGYLT----ERNLALVDALRAIAAEHGVTPAQLALAWLLAQpgVTSVIPGARSPEQLEENLAAADLELSAEDLAALD 307

                  ....*..
gi 1797152346 313 ELYKPHR 319
Cdd:COG0667   308 AALAAVP 314
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
21-315 1.43e-82

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 251.85  E-value: 1.43e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGEAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYA-KREDVIIATKFIPRtQEEIEQ 99
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPvKRDKVVIATKVPDG-DGPWPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 100 GIdAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKgye 179
Cdd:pfam00248  80 GG-SKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIP--- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 180 qFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHpGEESKRLSEDIYAKGKYDITHDEDLAIIHrVEEL 259
Cdd:pfam00248 156 -IVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGK-YTRDPDKGPGERRRLLKKGTPLNLEALEA-LEEI 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 260 AEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:pfam00248 233 AKEHGVSPAQVALRWALskPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
tas PRK10625
putative aldo-keto reductase; Provisional
1-316 6.73e-32

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 121.88  E-value: 6.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEAQKgmhswtlpYEESKKIIKYALDNGINFFDTAIGY--------QGGTsEAFLGK 72
Cdd:PRK10625    1 MQYHRIPHSSLEVSTLGLGTMTFGEQNS--------EADAHAQLDYAVAQGINLIDVAEMYpvpprpetQGLT-ETYIGN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  73 AIKEYAKREDVIIATKF---IPRTQEEI--EQGIDAKqHIENCLNGSLKRLDMDYVDLYILH--------------MWDY 133
Cdd:PRK10625   72 WLAKRGSREKLIIASKVsgpSRNNDKGIrpNQALDRK-NIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgySWTD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 134 NTPIE---DIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEE---REMKQYcvaHN 207
Cdd:PRK10625  151 SAPAVsllETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEvglAEVSQY---EG 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 208 IAMTPYSALASGRL-------AKHPGEESKRLSEDIyakgKYDITHDEdLAIIHRVeELAEKKGVSMTEISLAWLLTK-- 278
Cdd:PRK10625  228 VELLAYSCLAFGTLtgkylngAKPAGARNTLFSRFT----RYSGEQTQ-KAVAAYV-DIAKRHGLDPAQMALAFVRRQpf 301
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1797152346 279 VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYK 316
Cdd:PRK10625  302 VASTLLGATTMEQLKTNIESLHLTLSEEVLAEIEAVHQ 339
 
Name Accession Description Interval E-value
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
2-312 6.15e-167

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 466.68  E-value: 6.15e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCMGFGEAQKGmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKRE 81
Cdd:cd19079     1 EYVRLGNSGLKVSRLCLGCMSFGDPKWR--PWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC 161
Cdd:cd19079    79 EVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 162 YAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSED-IYAKG 240
Cdd:cd19079   159 YAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTtDTAKL 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 241 KYDITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19079   239 KYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKpgVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
1-319 1.29e-120

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 349.48  E-value: 1.29e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEAQkgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKR 80
Cdd:COG0667     1 MEYRRLGRSGLKVSRLGLGTMTFGGPW-----GGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGR-PR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKF-IPRTQEEIEQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:COG0667    75 DDVVIATKVgRRMGPGPNGRGLSRE-HIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIakAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA-----KHPGEESKRLSE 234
Cdd:COG0667   154 NYSAEQLRRALAI--AEGLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTgkyrrGATFPEGDRAAT 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 235 DIYAKGKYdithDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:COG0667   232 NFVQGYLT----ERNLALVDALRAIAAEHGVTPAQLALAWLLAQpgVTSVIPGARSPEQLEENLAAADLELSAEDLAALD 307

                  ....*..
gi 1797152346 313 ELYKPHR 319
Cdd:COG0667   308 AALAAVP 314
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
6-312 2.48e-99

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 294.90  E-value: 2.48e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   6 LGDSDLMVSKVCLGCMGFGEAQKgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKREDVII 85
Cdd:cd19080     3 LGRSGLRVSPLALGTMTFGTEWG----WGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAG--NRDRIVL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  86 ATKFI-PRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAW 164
Cdd:cd19080    77 ATKYTmNRRPGDPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRL-AKHPGEESKRLSEDIYAKGKYD 243
Cdd:cd19080   157 VVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLtGKYQRGEEGRAGEAKGVTVGFG 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 244 ITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19080   237 KLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKpgVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
1-314 3.47e-99

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 294.87  E-value: 3.47e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEaqkgmhswTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKR 80
Cdd:cd19087     1 MEYRTLGRTGLKVSRLCLGTMNFGG--------RTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG--RR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKFIPRTQEEI-EQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19087    71 DDIVLATKVFGPMGDDPnDRGLSRR-HIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALA----SGRLAKHPGEESKRLSED 235
Cdd:cd19087   150 NFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAggllTGKYGKGKRPESGRLVER 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 236 IYAKGKYdiTHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEE 313
Cdd:cd19087   230 ARYQARY--GLEEYRDIAERFEALAAEAGLTPASLALAWVLSHpaVTSPIIGPRTLEQLEDSLAALEITLTPELLAEIDE 307

                  .
gi 1797152346 314 L 314
Cdd:cd19087   308 L 308
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
1-314 5.40e-96

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 286.82  E-value: 5.40e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEAQKGMHSW-TLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKeyAK 79
Cdd:cd19091     1 MEYRTLGRSGLKVSELALGTMTFGGGGGFFGAWgGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALK--GR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  80 REDVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19091    79 RDDVLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA-KHPGEESKRLSEDIYA 238
Cdd:cd19091   159 NFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSgKYRRGQPAPEGSRLRR 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 239 KGKYDITHDEDLA--IIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19091   239 TGFDFPPVDRERGydVVDALREIAKETGATPAQVALAWLLSRptVSSVIIGARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
5-311 2.03e-87

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 264.85  E-value: 2.03e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   5 KLGDSDLMVSKVCLGCMGFGeaqkgmhsWTLPYEESKKIIKYALDNGINFFDTA-------IGYQGGTSEAFLGKAIKEY 77
Cdd:cd19081     1 PLGRTGLSVSPLCLGTMVFG--------WTADEETSFALLDAFVDAGGNFIDTAdvysawvPGNAGGESETIIGRWLKSR 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  78 AKREDVIIATKFIPRTQEEiEQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIG 157
Cdd:cd19081    73 GKRDRVVIATKVGFPMGPN-GPGLSRK-HIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 158 ISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREE-EREMKQYCVAHNIAMTPYSALASGRLA-K-HPGEESKRLSE 234
Cdd:cd19081   151 ASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGGFLTgKyRSEADLPGSTR 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 235 DIYAKGKYdiTHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYL 311
Cdd:cd19081   231 RGEAAKRY--LNERGLRILDALDEVAAEHGATPAQVALAWLLARpgVTAPIAGARTVEQLEDLLAAAGLRLTDEEVARL 307
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
11-306 6.16e-85

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 257.91  E-value: 6.16e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  11 LMVSKVCLGcmgfgeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVII 85
Cdd:cd19074     2 LKVSELSLG------------TWLtfggqVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGW-PRESYVI 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  86 ATK-FIPRTQEEIEQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAW 164
Cdd:cd19074    69 STKvFWPTGPGPNDRGLSRK-HIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAE 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA------KHPGEESKRLSEDIYA 238
Cdd:cd19074   148 QIAEAHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTgkyrdgIPPPSRSRATDEDNRD 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 239 KGKYDIThDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDE 306
Cdd:cd19074   228 KKRRLLT-DENLEKVKKLKPIADELGLTLAQLALAWCLRNpaVSSAIIGASRPEQLEENVKASGVKLSPE 296
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
10-312 5.79e-84

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 255.53  E-value: 5.79e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  10 DLMVSKVCLGCMGFGEAQKGMHSWtlpyEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakREDVIIATKF 89
Cdd:cd19084     1 DLKVSRIGLGTWAIGGTWWGEVDD----QESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR--RDDVVIATKC 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  90 IPRTQEEIEQGIDAK-QHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAK 168
Cdd:cd19084    75 GLRWDGGKGVTKDLSpESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 169 ANEIAKakgyeqFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALA----SGRLAKHPGEES-------KRLSEDIY 237
Cdd:cd19084   155 ARKYGP------IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAqgllTGKYKKEPTFPPddrrsrfPFFRGENF 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 238 AKGkydithdedLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19084   229 EKN---------LEIVDKLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
21-315 1.43e-82

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 251.85  E-value: 1.43e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGEAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYA-KREDVIIATKFIPRtQEEIEQ 99
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPvKRDKVVIATKVPDG-DGPWPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 100 GIdAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKgye 179
Cdd:pfam00248  80 GG-SKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIP--- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 180 qFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHpGEESKRLSEDIYAKGKYDITHDEDLAIIHrVEEL 259
Cdd:pfam00248 156 -IVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGK-YTRDPDKGPGERRRLLKKGTPLNLEALEA-LEEI 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 260 AEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:pfam00248 233 AKEHGVSPAQVALRWALskPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
14-297 1.55e-79

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 242.04  E-value: 1.55e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGeaqkgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKREDVIIATKFIPRT 93
Cdd:cd06660     1 SRLGLGTMTFG--------GDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGGHPP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  94 QEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIA 173
Cdd:cd06660    73 GGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 174 KAKGYEQFVSIQGHYNLIFREE-EREMKQYCVAHNIAMTPYSALASGrlakhpgeeskrlsediyakgkydithdedlai 252
Cdd:cd06660   153 KAHGLPGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARG--------------------------------- 199
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1797152346 253 ihrveelaekkgvsMTEISLAWLLTK--VTSPIIGATKPHHIDGAVK 297
Cdd:cd06660   200 --------------PAQLALAWLLSQpfVTVPIVGARSPEQLEENLA 232
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
13-315 5.92e-77

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 238.48  E-value: 5.92e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEAQKGMHSwTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKREDVIIATKFI-- 90
Cdd:cd19146    11 VSPLCLGAMSFGEAWKSMMG-ECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDEMVLATKYTtg 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 --PRTQEEIE---QGIDAKQ-HIEncLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAW 164
Cdd:cd19146    90 yrRGGPIKIKsnyQGNHAKSlRLS--VEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDTPAW 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLaKHPGEESKRLSEdiyakGKYDI 244
Cdd:cd19146   168 VVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQF-RTEEEFKRRGRS-----GRKGG 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 245 THDE-DLAIIHRVEELAEKKGVSMTEISLAWLLTKV--TSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:cd19146   242 PQTEkERKVSEKLEKVAEEKGTAITSVALAYVMHKApyVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIEDAY 315
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
13-317 5.39e-76

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 234.79  E-value: 5.39e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEAQkgmhsWTLPY--EESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKeyAKREDVIIATKFI 90
Cdd:cd19085     1 VSRLGLGCWQFGGGY-----WWGDQddEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALK--GRRDDVVIATKVS 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 PR--TQEEIEQGIDAkqhienclngSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAK 168
Cdd:cd19085    74 PDnlTPEDVRKSCER----------SLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEE 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 169 ANEIAKakgyeqFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAK--HPGEESK---------RLSEDIY 237
Cdd:cd19085   144 ALDAGR------IDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTGkfSSAEDFPpgdartrlfRHFEPGA 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 238 AKgkydithdEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:cd19085   218 EE--------ETFEALEKLKEIADELGVTMAQLALAWVLQQpgVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDEIS 289

                  ..
gi 1797152346 316 KP 317
Cdd:cd19085   290 DP 291
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
2-314 1.40e-72

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 226.71  E-value: 1.40e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCMGFGEAQKGMhswtlPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKRE 81
Cdd:cd19076     1 PTRKLGTQGLEVSALGLGCMGMSAFYGPA-----DEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKD--RRD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKF-IPRTQEEIEQGIDAK-QHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19076    74 EVVIATKFgIVRDPGSGFRGVDGRpEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIAKakgyeqFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA---KHPGEESK------ 230
Cdd:cd19076   154 EASADTIRRAHAVHP------ITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTgaiKSPEDLPEddfrrn 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 231 --RLSEDIYAKgkydithdeDLAIIHRVEELAEKKGVSMTEISLAWLLTK----VtsPIIGATKPHHIDGAVKAVAVKLT 304
Cdd:cd19076   228 npRFQGENFDK---------NLKLVEKLEAIAAEKGCTPAQLALAWVLAQgddiV--PIPGTKRIKYLEENVGALDVVLT 296
                         330
                  ....*....|
gi 1797152346 305 DEEiiyLEEL 314
Cdd:cd19076   297 PEE---LAEI 303
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
13-312 3.41e-68

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 215.17  E-value: 3.41e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEaQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKREDVIIATKF--I 90
Cdd:cd19093     2 VSPLGLGTWQWGD-RLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATKFapL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 PRTQeeieqgidAKQHIENCLNGSLKRLDMDYVDLYILHM-WDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKA 169
Cdd:cd19093    81 PWRL--------TRRSVVKALKASLERLGLDSIDLYQLHWpGPWYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 170 NEIAKAKGYEqFVSIQGHYNLIFRE-EEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRlsEDIYAKGKYDITHDE 248
Cdd:cd19093   153 HKALKERGVP-LASNQVEYSLLYRDpEQNGLLPACDELGITLIAYSPLAQGLLTGKYSPENPP--PGGRRRLFGRKNLEK 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 249 DLAIIHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19093   230 VQPLLDALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
4-315 8.87e-66

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 209.20  E-value: 8.87e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   4 VKLGDSDLMVSkvclgCMGFGEAQKGMHSW--TLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKRE 81
Cdd:cd19083     2 VKLGKSDIDVN-----PIGLGTNAVGGHNLypNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEY-NRN 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC 161
Cdd:cd19083    76 EVVIATKGAHKFGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 162 YAWQIAKANeiakAKGYEQfvSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKrLSEDIYAKGK 241
Cdd:cd19083   156 SLEQLKEAN----KDGYVD--VLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGKYTKDTK-FPDNDLRNDK 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 242 YDITHDEDLAIIHRVEEL---AEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:cd19083   229 PLFKGERFSENLDKVDKLksiADEKGVTVAHLALAWYLTRpaIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDALF 307
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
13-306 2.28e-65

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 208.96  E-value: 2.28e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEAQkgmhswTLpyEESKKIIKYALDNGINFFDTAIGY-------QGGTSEAFLGKAIKEYAKREDVII 85
Cdd:cd19094     1 VSEICLGTMTWGEQN------TE--AEAHEQLDYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKKKGNRDKVVL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  86 ATKFIPRTqEEIEQGIDA-----KQHIENCLNGSLKRLDMDYVDLYILHMWDYNTP------------------IEDIMA 142
Cdd:cd19094    73 ATKVAGPG-EGITWPRGGgtrldRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPlfgggyytepseeedsvsFEEQLE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 143 ALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA 222
Cdd:cd19094   152 ALGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLT 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 223 ---KHPGEESKRLSEDIYAKGKYDITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVK 297
Cdd:cd19094   232 gkyLDGAARPEGGRLNLFPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRpfVTSTIIGATTLEQLKENID 311

                  ....*....
gi 1797152346 298 AVAVKLTDE 306
Cdd:cd19094   312 AFDVPLSDE 320
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
39-315 3.91e-63

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 202.52  E-value: 3.91e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  39 ESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakREDVIIATK--FIPRTQEEIEQGIDAKQhIENCLNGSLK 116
Cdd:cd19102    27 DSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL--RDRPIVATKcgLLWDEEGRIRRSLKPAS-IRAECEASLR 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 117 RLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKgyeqfvSIQGHYNLIFREEE 196
Cdd:cd19102   104 RLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPIA------SLQPPYSLLRRGIE 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 197 REMKQYCVAHNIAMTPYSALASGRLAKHPGEES-KRLSEDIYAKGKYDITHD---EDLAIIHRVEELAEKKGVSMTEISL 272
Cdd:cd19102   178 AEILPFCAEHGIGVIVYSPMQSGLLTGKMTPERvASLPADDWRRRSPFFQEPnlaRNLALVDALRPIAERHGRTVAQLAI 257
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1797152346 273 AWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELY 315
Cdd:cd19102   258 AWVLrrPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEALL 302
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
14-298 6.48e-63

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 201.24  E-value: 6.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGeaqkgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQG----GTSEAFLGKAIKEYAKREDVIIATK- 88
Cdd:cd19082     1 SRIVLGTADFG--------TRIDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRGNRDKVVIATKg 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  89 --------FIPR-TQEEIEQgiDakqhiencLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19082    73 ghpdledmSRSRlSPEDIRA--D--------LEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGAS 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NcyaW---QIAKANEIAKAKGYEQFVSIQGHYNLIFREEER-----------EMKQYCVAHNIAMTPYSALASGRLAKHP 225
Cdd:cd19082   143 N---WsteRIAEANAYAKAHGLPGFAASSPQWSLARPNEPPwpgptlvamdeEMRAWHEENQLPVFAYSSQARGFFSKRA 219
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 226 GEESKRLSEDiyaKGKYDitHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKA 298
Cdd:cd19082   220 AGGAEDDSEL---RRVYY--SEENFERLERAKELAEEKGVSPTQIALAYVLNQpfPTVPIIGPRTPEQLRDSLAA 289
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
10-313 9.88e-61

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 196.30  E-value: 9.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  10 DLMVSKVCLGCMGFGEAQKGMHSwtlpYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakREDVIIATKF 89
Cdd:cd19078     1 GLEVSAIGLGCMGMSHGYGPPPD----KEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF--RDQVVIATKF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  90 ---IPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNcyawqi 166
Cdd:cd19078    75 gfkIDGGKPGPLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSE------ 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 167 AKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESK-----------RLSED 235
Cdd:cd19078   149 AGVETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKfdegddraslpRFTPE 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 236 IYAKgkydithdeDLAIIHRVEELAEKKGVSMTEISLAWLLTK----VtsPIIGATKPHHIDGAVKAVAVKLTDEEIIYL 311
Cdd:cd19078   229 ALEA---------NQALVDLLKEFAEEKGATPAQIALAWLLAKkpwiV--PIPGTTKLSRLEENIGAADIELTPEELREI 297

                  ..
gi 1797152346 312 EE 313
Cdd:cd19078   298 ED 299
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
1-306 7.93e-60

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 194.35  E-value: 7.93e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGC-MGFGEAQKGmhswtlpyEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYA- 78
Cdd:cd19143     1 MEYRRLGRSGLKVSALSFGSwVTFGNQVDV--------DEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGw 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  79 KREDVIIATKFI------PRTQeeieQGIDAKQHIENClNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGK 152
Cdd:cd19143    73 PRSDYVVSTKIFwggggpPPND----RGLSRKHIVEGT-KASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGK 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 153 VRYIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREE-EREMKQYCVAHNIAMTPYSALASGRL-AKHPGE--E 228
Cdd:cd19143   148 AFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRERvEVEYAPLYEKYGLGTTTWSPLASGLLtGKYNNGipE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 229 SKRLSEDIYaKGKYDITHDEDLAIIHRVEEL---AEKKGVSMTEISLAWLLT--KVTSPIIGATKPHHIDGAVKAVAV-- 301
Cdd:cd19143   228 GSRLALPGY-EWLKDRKEELGQEKIEKVRKLkpiAEELGCSLAQLAIAWCLKnpNVSTVITGATKVEQLEENLKALEVlp 306

                  ....*
gi 1797152346 302 KLTDE 306
Cdd:cd19143   307 KLTPE 311
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
3-313 8.89e-60

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 194.03  E-value: 8.89e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSKVCLGCMGFGeaqKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKRED 82
Cdd:cd19149     1 YRKLGKSGIEASVIGLGTWAIG---GGPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKG--RRDK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  83 VIIATKF-----IPRTQEEIEQ-GID-----AKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQG 151
Cdd:cd19149    76 VVLATKCglrwdREGGSFFFVRdGVTvyknlSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 152 KVRYIGISNCYAWQIAKANEiakakgYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKR 231
Cdd:cd19149   156 KIRAIGASNVSVEQIKEYVK------AGQLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKITPDREF 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 232 LSEDIYAKGK-YDITHDED-LAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEE 307
Cdd:cd19149   230 DAGDARSGIPwFSPENREKvLALLEKWKPLCEKYGCTLAQLVIAWTLAQpgITSALCGARKPEQAEENAKAGDIRLSAED 309

                  ....*.
gi 1797152346 308 IIYLEE 313
Cdd:cd19149   310 IATMRS 315
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
13-308 1.03e-59

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 192.06  E-value: 1.03e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEaqkGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIATKFIPR 92
Cdd:cd19072     4 VPVLGLGTWGIGG---GMSKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGF-DREDLFITTKVSPD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  93 TQeeieqgidAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC------YAWQI 166
Cdd:cd19072    80 HL--------KYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFsleeleEAQSY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 167 AKANEIakakgyeqfVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESkrlsediyakgkydith 246
Cdd:cd19072   152 LKKGPI---------VANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKGSPL----------------- 205
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1797152346 247 dedlaiihrVEELAEKKGVSMTEISLAWLLTK-VTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19072   206 ---------LDEIAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDL 259
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
14-299 2.86e-58

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 189.47  E-value: 2.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGEaqkgmhswTLPYEESKKIIKYALDNGINFFDTA-------IGYQGGTSEAFLGKAIKEYAKREDVIIA 86
Cdd:cd19752     1 SELCLGTMYFGT--------RTDEETSFAILDRYVAAGGNFLDTAnnyafwtEGGVGGESERLIGRWLKDRGNRDDVVIA 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  87 TKF-----IPRTQEEIEQGIDAKQhIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNC 161
Cdd:cd19752    73 TKVgagprDPDGGPESPEGLSAET-IEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNF 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 162 YAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEER----------EMKQYCVAH-NIAMTPYSALASGRLAKhpgeESK 230
Cdd:cd19752   152 AAWRLERARQIARQQGWAEFSAIQQRHSYLRPRPGAdfgvqrivtdELLDYASSRpDLTLLAYSPLLSGAYTR----PDR 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 231 RLSEDiyakgkYDitHDEDLAIIHRVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAV 299
Cdd:cd19752   228 PLPEQ------YD--GPDSDARLAVLEEVAGELGATPNQVVLAWLLhrTPAIIPLLGASTVEQLEENLAAL 290
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
11-298 2.68e-56

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 182.68  E-value: 2.68e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  11 LMVSKVCLGCMGFGEAQKGMHSwtlpYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKREDVIIATKFI 90
Cdd:cd19086     1 LEVSEIGFGTWGLGGDWWGDVD----DAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG--RRDKVVIATKFG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 PRTQEEIEQGIDA-KQHIENCLNGSLKRLDMDYVDLYILHMWDYN-TPIEDIMAALHDVIRQGKVRYIGISncyawqIAK 168
Cdd:cd19086    75 NRFDGGPERPQDFsPEYIREAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVS------VGD 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 169 ANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHN---IAMTPysaLASGRLAkhpgeeskrlsediyakGKydit 245
Cdd:cd19086   149 PEEALAALRRGGIDVVQVIYNLLDQRPEEELFPLAEEHGvgvIARVP---LASGLLT-----------------GK---- 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 246 hdedlaiihrveelaekkgvsMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKA 298
Cdd:cd19086   205 ---------------------LAQAALRFILSHpaVSTVIPGARSPEQVEENAAA 238
AKR_AKR9A3_9B1-4 cd19147
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ...
13-312 3.46e-55

Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381373 [Multi-domain]  Cd Length: 319  Bit Score: 182.33  E-value: 3.46e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFGEAQKG-MHSwtLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKREDVIIATKF-I 90
Cdd:cd19147    10 VSPLILGAMSIGDAWSGfMGS--MDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRDQIVIATKFtT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 PRTQEEIEQGIDA------KQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAW 164
Cdd:cd19147    88 DYKAYEVGKGKAVnycgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSDTPAW 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRL-AKHPGEESKRLSEDIYAKGKYD 243
Cdd:cd19147   168 VVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFqSKKAVEERKKNGEGLRSFVGGT 247
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 244 ITHDEDLAIIHRVEELAEKKGV-SMTEISLAWLLTKVTS--PIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19147   248 EQTPEEVKISEALEKVAEEHGTeSVTAIALAYVRSKAPNvfPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
10-314 4.75e-55

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 181.38  E-value: 4.75e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  10 DLMVSKVCLGCMGFG---EAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIA 86
Cdd:cd19103     1 DKKLPKIALGTWSWGsggAGGDQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRY-PREDYIIS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  87 TKFIPrtqeeieQGIDAKQH-IENCLNGSLKRLDMDYVDLYILHMwdyNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQ 165
Cdd:cd19103    80 TKFTP-------QIAGQSADpVADMLEGSLARLGTDYIDIYWIHN---PADVERWTPELIPLLKSGKVKHVGVSNHNLAE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 166 IAKANEIAKAKGYEqFVSIQGHYNLIFREEERE-MKQYCVAHNIAMTPYSALASGRLAKHPGEEsKRLSEDIYAKGKYDI 244
Cdd:cd19103   150 IKRANEILAKAGVS-LSAVQNHYSLLYRSSEEAgILDYCKENGITFFAYMVLEQGALSGKYDTK-HPLPEGSGRAETYNP 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 245 THDEDLAIIHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19103   228 LLPQLEELTAVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
3-308 2.67e-54

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 179.76  E-value: 2.67e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSKVCLGC-MGFGEAQkgmhswtlPYEESKKIIKYALDNGINFFDTAIGYQG--GTSEAFLGKAIKE--Y 77
Cdd:cd19089     1 YRRCGRSGLHLPAISLGLwHNFGDYT--------SPEEARELLRTAFDLGITHFDLANNYGPppGSAEENFGRILKRdlR 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  78 AKREDVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIG 157
Cdd:cd19089    73 PYRDELVISTKAGYGMWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 158 ISNCYAWQIAKANEIAKAKGYeQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA----KHPGEESKRLS 233
Cdd:cd19089   153 ISNYPGAKARRAIALLRELGV-PLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTdkylNGIPPDSRRAA 231
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 234 EDIYAKGKYdIThDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAV-AVKLTDEEI 308
Cdd:cd19089   232 ESKFLTEEA-LT-PEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDprVTSVLIGASSPSQLEDNVAALkNLDFSEEEL 307
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
4-314 4.28e-52

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 173.77  E-value: 4.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   4 VKLGDSDLMVSKVCLGCMGFgeaqKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyAKREDV 83
Cdd:cd19145     3 VKLGSQGLEVSAQGLGCMGL----SGDYGAPKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKD-GPREKV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  84 IIATKFIPRTQEEieQGIDAK---QHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISN 160
Cdd:cd19145    78 QLATKFGIHEIGG--SGVEVRgdpAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 161 cyawqiAKANEIAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKrLSEDIYAKg 240
Cdd:cd19145   156 ------ASADTIRRAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEEL-LENSDVRK- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 241 KYDITHDEDL----AIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEiiyLEEL 314
Cdd:cd19145   228 SHPRFQGENLeknkVLYERVEALAKKKGCTPAQLALAWVLHQgeDVVPIPGTTKIKNLNQNIGALSVKLTKED---LKEI 304
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
21-304 8.54e-51

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 168.94  E-value: 8.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGeaqkGMHsWTLPY--------EESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakREDVIIATKF-IP 91
Cdd:cd19088     4 LGYG----AMR-LTGPGiwgppadrEEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPY--PDDVVIATKGgLV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  92 RTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNcyawqiAKANE 171
Cdd:cd19088    77 RTGPGWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSN------VTVAQ 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 172 IAKAKGYEQFVSIQGHYNLIFREEErEMKQYCVAHNIAMTPYSALASGRLAKHPGEeskrlsediyakgkydithdedla 251
Cdd:cd19088   151 IEEARAIVRIVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDLAQPGGL------------------------ 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 252 iihrVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLT 304
Cdd:cd19088   206 ----LAEVAARLGATPAQVALAWLLarSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
9-307 1.40e-49

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 166.96  E-value: 1.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   9 SDLMVSKVCLGCMGFGEaqkgmhsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEY-AKREDVIIAT 87
Cdd:cd19092     2 EGLEVSRLVLGCMRLAD-------WGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNpGLREKIEIQT 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  88 KF-IPRTQEEIEQGI---DA-KQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCY 162
Cdd:cd19092    75 KCgIRLGDDPRPGRIkhyDTsKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFT 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 163 AWQIAK----------ANEIakakgyeQFvSIqGHYNLIFreeeREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRL 232
Cdd:cd19092   155 PSQIELlqsyldqplvTNQI-------EL-SL-LHTEAID----DGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRL 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 233 SEDIyakgkydithdedlaiihrvEELAEKKGVSMTEISLAWLLT---KVtSPIIGATKPHHIDGAVKAVAVKLTDEE 307
Cdd:cd19092   222 RAAL--------------------EELAEEYGVTIEAIALAWLLRhpaRI-QPILGTTNPERIRSAVKALDIELTREE 278
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
1-316 9.50e-49

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 166.92  E-value: 9.50e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGeaqkgmhswTLPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYakR 80
Cdd:COG1453     1 MQYRRLGKTGLEVSVLGFGGMRLP---------RKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALKGP--R 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKFIPRTQeeieqgiDAKQhIENCLNGSLKRLDMDYVDLYILH----MWDYNTPIED--IMAALHDVIRQGKVR 154
Cdd:COG1453    68 DKVILATKLPPWVR-------DPED-MRKDLEESLKRLQTDYIDLYLIHglntEEDLEKVLKPggALEALEKAKAEGKIR 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 155 YIGISNCYAWQIAKanEIAKAKGYEqFVSIQghYNLIFREEEREMK--QYCVAHNIAMTPYSALASGRLAKHPGEeskrl 232
Cdd:COG1453   140 HIGFSTHGSLEVIK--EAIDTGDFD-FVQLQ--YNYLDQDNQAGEEalEAAAEKGIGVIIMKPLKGGRLANPPEK----- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 233 sediyakgkydithdedlaiihrVEELAEKKgVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAV--AVKLTDEEI 308
Cdd:COG1453   210 -----------------------LVELLCPP-LSPAEWALRFLLSHpeVTTVLSGMSTPEQLDENLKTAdnLEPLTEEEL 265

                  ....*...
gi 1797152346 309 IYLEELYK 316
Cdd:COG1453   266 AILERLAE 273
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
15-299 6.32e-47

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 160.41  E-value: 6.32e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  15 KVCLGCMGFGEAQKgmhSWTLpyEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIkeyAKREDVIIATKFIPRTQ 94
Cdd:cd19075     2 KIILGTMTFGSQGR---FTTA--EAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELG---LGERGFKIDTKANPGVG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  95 eeieqGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAK 174
Cdd:cd19075    74 -----GGLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 175 AKGYeqfvsI-----QGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSE----------DIYaK 239
Cdd:cd19075   149 ENGW-----VlptvyQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSEDKAGGgrfdpnnalgKLY-R 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 240 GKYDitHDEDLAIIHRVEELAEKKGVSMTEISLAWLLTKvtSP---------IIGATKPHHIDGAVKAV 299
Cdd:cd19075   223 DRYW--KPSYFEALEKVEEAAEKEGISLAEAALRWLYHH--SAldgekgdgvILGASSLEQLEENLAAL 287
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
1-322 6.41e-45

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 155.68  E-value: 6.41e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFgEAQKGMHSwtlPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKE-YAK 79
Cdd:cd19144     1 IPTRTLGRNGPSVPALGFGAMGL-SAFYGPPK---PDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWFKQnPGK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  80 REDVIIATKF-IPRTQEEIEQGIDAK-QHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIG 157
Cdd:cd19144    75 REKIFLATKFgIEKNVETGEYSVDGSpEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 158 ISNCyawqiaKANEIAKAKGYEQFVSIQGHYN---LIFREEEREMKQYCVAHNIAMTPYSALASGRLAK--------HPG 226
Cdd:cd19144   155 LSEC------SAETLRRAHAVHPIAAVQIEYSpfsLDIERPEIGVLDTCRELGVAIVAYSPLGRGFLTGairspddfEEG 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 227 EESK---RLSEDIYAKgkydithdeDLAIIHRVEELAEKKGVSMTEISLAWLLTKVTS--PIIGATKPHHIDGAVKAVAV 301
Cdd:cd19144   229 DFRRmapRFQAENFPK---------NLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDiiPIPGTTKLKRLEENLGALKV 299
                         330       340
                  ....*....|....*....|.
gi 1797152346 302 KLTDEEIIYLEELYKPHRLVG 322
Cdd:cd19144   300 KLTEEEEKEIREIAEEAEVVG 320
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
2-308 9.47e-44

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 152.17  E-value: 9.47e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCM-GFGEAQKgmhswtlpYEESKKIIKYALDNGINFFDTAIGY--QGGTSEAFLGKAIKEYA 78
Cdd:cd19151     1 KYNRCGRSGLKLPAISLGLWhNFGDVDR--------YENSRAMLRRAFDLGITHFDLANNYgpPPGSAEENFGRILKEDL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  79 K--REDVIIATKFIPRTQEEIEQGIDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYI 156
Cdd:cd19151    73 KpyRDELIISTKAGYTMWPGPYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 157 GISNCYAWQIAKANEIAKAKGYEQFVSiQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKH-----PgEESKR 231
Cdd:cd19151   153 GISNYPPEEAREAAAILKDLGTPCLIH-QPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRylngiP-EDSRA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 232 LSEDIYAKgKYDIThDEDLAIIHRVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVA-VKLTDEEI 308
Cdd:cd19151   231 AKGSSFLK-PEQIT-EEKLAKVRRLNEIAQARGQKLAQMALAWVLrnKRVTSVLIGASKPSQIEDAVGALDnREFSEEEL 308
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
22-320 1.16e-43

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 150.59  E-value: 1.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  22 GFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-AKREDVIIATKFIPRTQ--EEIE 98
Cdd:COG0656     9 GLG-------TWQLPGEEAAAAVRTALEAGYRHIDTAAMYG---NEEGVGEAIAASgVPREELFVTTKVWNDNHgyDDTL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  99 QGIDAkqhienclngSLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKgy 178
Cdd:COG0656    79 AAFEE----------SLERLGLDYLDLYLIH-WPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVK-- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 179 eqFVSIQGHYNLIFReeEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEE 258
Cdd:COG0656   146 --PAVNQVELHPYLQ--QRELLAFCREHGIVVEAYSPLGRGKLLDDP-----------------------------VLAE 192
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 259 LAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:COG0656   193 IAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
1-299 1.97e-42

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 146.96  E-value: 1.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEaqkgmhswtlpyeESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKR 80
Cdd:cd19105     1 MPYRTLGKTGLKVSRLGFGGGGLPR-------------ESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGL-RR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKFIPRTQEeieqgiDAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPI---EDIMAALHDVIRQGKVRYIG 157
Cdd:cd19105    67 DKVFLATKASPRLDK------KDKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIG 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 158 ISnCYAWQIAKANEIAKAKGYEqfvSIQGHYNLIFREEERE--MKQyCVAHNIAMTPYSALASGRLakhpgeeskrlsed 235
Cdd:cd19105   141 FS-THDNMAEVLQAAIESGWFD---VIMVAYNFLNQPAELEeaLAA-AAEKGIGVVAMKTLAGGYL-------------- 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1797152346 236 iyakgkyditHDEDLAIIhrveelaEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAV 299
Cdd:cd19105   202 ----------QPALLSVL-------KAKGFSLPQAALKWVLSNprVDTVVPGMRNFAELEENLAAA 250
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
10-307 4.42e-42

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 147.84  E-value: 4.42e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  10 DLMVSKVCLGCMGFGEAQkgmhsWTLPYE-ESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAKREDVIIATK 88
Cdd:cd19148     1 DLPVSRIALGTWAIGGWM-----WGGTDEkEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  89 FIPRTQEEIEQGIDA-KQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIA 167
Cdd:cd19148    76 VGLEWDEGGEVVRNSsPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQME 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 168 KANEIAKakgyeqFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLA-------KHPGEESKRlSEDIYAKG 240
Cdd:cd19148   156 TFRKVAP------LHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSgkmtkdtKFEGDDLRR-TDPKFQEP 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 241 KYdithDEDLAIIHRVEELAEKK-GVSMTEISLAWLLTKVTSPII--GATKPHHIDGAVKAVAVKLTDEE 307
Cdd:cd19148   229 RF----SQYLAAVEELDKLAQERyGKSVIHLAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDED 294
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
3-228 1.78e-41

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 144.16  E-value: 1.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSKVCLGCMGFGEaqkgmhswtLPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYakRED 82
Cdd:cd19100     1 YRRLGRTGLKVSRLGFGGGPLGR---------LSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKGR--RDK 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  83 VIIATKFIPRTQEEieqgidAKQHIENclngSLKRLDMDYVDLYILH----MWDYNTPIED--IMAALHDVIRQGKVRYI 156
Cdd:cd19100    68 VFLATKTGARDYEG------AKRDLER----SLKRLGTDYIDLYQLHavdtEEDLDQVFGPggALEALLEAKEEGKIRFI 137
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 157 GISnCYAWQIAKaneiaKAKGYEQFVSIQGHYNLIFREEEREMKQ---YCVAHNIAMTPYSALASGRLAKHPGEE 228
Cdd:cd19100   138 GIS-GHSPEVLL-----RALETGEFDVVLFPINPAGDHIDSFREEllpLAREKGVGVIAMKVLAGGRLLSGDPLD 206
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
13-315 1.07e-40

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 144.30  E-value: 1.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  13 VSKVCLGCMGFgeaqkgmhSWT---LPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAF-----LGKAIKEY-AKREDV 83
Cdd:cd19077     5 VGPIGLGLMGL--------TWRpnpTPDEEAFETMKAALDAGSNLWNGGEFY--GPPDPHanlklLARFFRKYpEYADKV 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  84 IIATKF-------IPRTQEEieqgiDAKQHIENCLngslKRLDM-DYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRY 155
Cdd:cd19077    75 VLSVKGgldpdtlRPDGSPE-----AVRKSIENIL----RALGGtKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 156 IGISNCYAWQIAKANEIAKakgyeqFVSIQGHYNLIFRE-EEREMKQYCVAHNIAMTPYSALASGRLA---KHPGEE--- 228
Cdd:cd19077   146 IGLSEVSAETIRRAHAVHP------IAAVEVEYSLFSREiEENGVLETCAELGIPIIAYSPLGRGLLTgriKSLADIpeg 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 229 -----SKRLSEDIYAKgkydithdeDLAIIHRVEELAEKKGVSMTEISLAWLLTKVTS---PIIGATKPHHIDGAVKAVA 300
Cdd:cd19077   220 dfrrhLDRFNGENFEK---------NLKLVDALQELAEKKGCTPAQLALAWILAQSGPkiiPIPGSTTLERVEENLKAAN 290
                         330
                  ....*....|....*
gi 1797152346 301 VKLTDEEiiyLEELY 315
Cdd:cd19077   291 VELTDEE---LKEIN 302
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
14-306 1.54e-40

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 143.08  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGEAQKGmhswtLPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYaKREDVIIATKFIPRT 93
Cdd:cd19090     1 SALGLGTAGLGGVFGG-----VDDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGLALAEL-PREPLVLSTKVGRLP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  94 QEEIEQGIDA-KQHIENclngSLKRLDMDYVDLYILH-----MWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYA---W 164
Cdd:cd19090    73 EDTADYSADRvRRSVEE----SLERLGRDRIDLLMIHdpervPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPdllR 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYeqfvsiqGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEeskrlsediYAKGKYDI 244
Cdd:cd19090   149 RAIETGDFDVVLTA-------NRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPPE---------RVRYTYRW 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 245 THDEDLAIIHRVEELAEKKGVSMTEISLAWLLT--KVTSPIIGATKPHHIDGAVKAVAVKLTDE 306
Cdd:cd19090   213 LSPELLDRAKRLYELCDEHGVPLPALALRFLLRdpRISTVLVGASSPEELEQNVAAAEGPLPEE 276
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
2-315 3.19e-39

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 140.86  E-value: 3.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   2 EYVKLGDSDLMVSKVCLGCMGFGEAqkgmhsWTL-PYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyaKR 80
Cdd:cd19104     1 KYRRFGRTGLKVSELTFGGGGIGGL------MGRtTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKG--LP 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKfIPRTQEEIEqgiDAKQHIENCLNGSLKRLDMDYVDLYILH---------MWDYNTPIEDIM------AALH 145
Cdd:cd19104    73 AGPYITTK-VRLDPDDLG---DIGGQIERSVEKSLKRLKRDSVDLLQLHnrigderdkPVGGTLSTTDVLglggvaDAFE 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 146 DVIRQGKVRYIGISncyAWQIAKAneIAKAKGYEQFVSIQGHYNLI------------FREEEREMKQYCVAHNIAMTPY 213
Cdd:cd19104   149 RLRSEGKIRFIGIT---GLGNPPA--IRELLDSGKFDAVQVYYNLLnpsaaearprgwSAQDYGGIIDAAAEHGVGVMGI 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 214 SALASGRLAKHP--GEESKRLSEDIYAKgkydithDEDLAIihRVEELAEKKGVSMTEISLAWLLT--KVTSPIIGATKP 289
Cdd:cd19104   224 RVLAAGALTTSLdrGREAPPTSDSDVAI-------DFRRAA--AFRALAREWGETLAQLAHRFALSnpGVSTVLVGVKNR 294
                         330       340
                  ....*....|....*....|....*..
gi 1797152346 290 HHIDGAVKAVAV-KLTDEEIIYLEELY 315
Cdd:cd19104   295 EELEEAVAAEAAgPLPAENLARLEALW 321
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
21-312 2.78e-38

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 136.46  E-value: 2.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFIPRTQeeieq 99
Cdd:cd19071     4 IGLG-------TYKLKPEETAEAVLAALEAGYRHIDTAAAYG---NEAEVGEAIRESGvPREELFITTKLWPTDH----- 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 100 gidAKQHIENCLNGSLKRLDMDYVDLYILH---MWDYNTPIEDIMA---ALHDVIRQGKVRYIGISNCYAWQIAKANEIA 173
Cdd:cd19071    69 ---GYERVREALEESLKDLGLDYLDLYLIHwpvPGKEGGSKEARLEtwrALEELVDEGLVRSIGVSNFNVEHLEELLAAA 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 174 KAKGyeqfVSIQGHYNLIFREeeREMKQYCVAHNIAMTPYSALASGR--LAKHPgeeskrlsediyakgkydithdedla 251
Cdd:cd19071   146 RIKP----AVNQIELHPYLQQ--KELVEFCKEHGIVVQAYSPLGRGRrpLLDDP-------------------------- 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 252 iihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19071   194 ---VLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
29-308 2.99e-38

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 135.86  E-value: 2.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-AKREDVIIATKfIPRtqeeieQGIDAKQHI 107
Cdd:cd19073     5 GLGTWQLRGDDCANAVKEALELGYRHIDTAEIYN---NEAEVGEAIAESgVPREDLFITTK-VWR------DHLRPEDLK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 108 ENCLNgSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAK-GYEQfvsIQG 186
Cdd:cd19073    75 KSVDR-SLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPiAVNQ---VEF 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 187 HYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEKKGVS 266
Cdd:cd19073   151 HPFL----YQAELLEYCRENDIVITAYSPLARGEVLRDP-----------------------------VIQEIAEKYDKT 197
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1797152346 267 MTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19073   198 PAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDV 239
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
3-312 6.66e-37

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 133.14  E-value: 6.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLmVSKVCLGCMGFGEaqkGMHSWtlpyEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakRED 82
Cdd:cd19138     2 TVTLPDGTK-VPALGQGTWYMGE---DPAKR----AQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGR--RDK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  83 VIIATKFIPRTQeeieqgidAKQHIENCLNGSLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIRQGKVRYIGISNCY 162
Cdd:cd19138    72 VFLVSKVLPSNA--------SRQGTVRACERSLRRLGTDYLDLYLLH-WRGGVPLAETVAAMEELKKEGKIRAWGVSNFD 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 163 ------AWQIAKANEIAkakgyeqfvSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSedi 236
Cdd:cd19138   143 tddmeeLWAVPGGGNCA---------ANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRRGLLENPTLK--- 210
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 237 yakgkydithdedlaiihrveELAEKKGVSMTEISLAWLL-TKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19138   211 ---------------------EIAARHGATPAQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
44-308 5.03e-36

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 130.82  E-value: 5.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  44 IKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-AKREDVIIATKFIPRTQeeieqgidakqHIENCLNGSLKRLDMDY 122
Cdd:cd19120    31 VKLALKAGFRHIDTAEMYG---NEKEVGEALKESgVPREDLFITTKVSPGIK-----------DPREALRKSLAKLGVDY 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 123 VDLYILHM--WDYN--TPIEDIMAALHDVIRQGKVRYIGISNcyaWQIAKANEIAKAKGYEQFVS-IQGHYNLIFREEEr 197
Cdd:cd19120    97 VDLYLIHSpfFAKEggPTLAEAWAELEALKDAGLVRSIGVSN---FRIEDLEELLDTAKIKPAVNqIEFHPYLYPQQPA- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 198 eMKQYCVAHNIAMTPYSALASgrlakhpgeeskrlsediyakgkydITHDEDLAIIHRVEELAEKKGVSMTEISLAWLLT 277
Cdd:cd19120   173 -LLEYCREHGIVVSAYSPLSP-------------------------LTRDAGGPLDPVLEKIAEKYGVTPAQVLLRWALQ 226
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1797152346 278 KVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19120   227 KGIVVVTTSSKEERMKEYLEAFDFELTEEEV 257
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
48-308 7.99e-36

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 131.18  E-value: 7.99e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  48 LDNGINFFDTAIGYqgGTSEAFLGKAIKEYAKR----EDVIIATKFIPRTQEeieQGIDaKQHIENCLNGSLKRLDMDYV 123
Cdd:cd19101    33 VDAGLTTFDCADIY--GPAEELIGEFRKRLRRErdaaDDVQIHTKWVPDPGE---LTMT-RAYVEAAIDRSLKRLGVDRL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 124 DLYILHMWDYNTP-IEDIMAALHDVIRQGKVRYIGISNCYAWQIAkanEIAKAkGYEqFVSIQGHYNLIFREEEREMKQY 202
Cdd:cd19101   107 DLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLR---EILDA-GVP-IVSNQVQYSLLDRRPENGMAAL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 203 CVAHNIAMTPYSALASGRLA-KHPGE-ESKRLSEDIYAKGKYDITHDE------------DLAIIhrveelAEKKGVSMT 268
Cdd:cd19101   182 CEDHGIKLLAYGTLAGGLLSeKYLGVpEPTGPALETRSLQKYKLMIDEwggwdlfqellrTLKAI------ADKHGVSIA 255
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1797152346 269 EISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19101   256 NVAVRWVLDQpgVAGVIVGARNSEHIDDNVRAFSFRLDDEDR 297
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
3-304 1.30e-35

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 131.03  E-value: 1.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSkvclgCMGFGeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEY 77
Cdd:cd19141     2 YRNLGKSGLRVS-----CLGLG-------TWVtfgsqISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKK 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  78 A-KREDVIIATKFIPRTQEEIEQGIDAKQHIENcLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYI 156
Cdd:cd19141    70 GwRRSSYVITTKIFWGGKAETERGLSRKHIIEG-LKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYW 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 157 GISNCYAWQIAKANEIAKakgyeQF-----VSIQGHYNLiFREEEREMKQYCVAHNI---AMTpYSALASGRLAKHPGE- 227
Cdd:cd19141   149 GTSRWSAMEIMEAYSVAR-----QFnlippIVEQAEYHL-FQREKVEMQLPELFHKIgvgAMT-WSPLACGILSGKYDDg 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 228 --ESKRLSEDIYAKGKYDITHDE---DLAIIHRVEELAEKKGVSMTEISLAWLLT--KVTSPIIGATKPHHIDGAVKAVA 300
Cdd:cd19141   222 vpEYSRASLKGYQWLKEKILSEEgrrQQAKLKELQIIADRLGCTLPQLAIAWCLKneGVSSVLLGASSTEQLYENLQAIQ 301

                  ....*.
gi 1797152346 301 V--KLT 304
Cdd:cd19141   302 VlpKLT 307
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
38-308 1.56e-35

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 129.61  E-value: 1.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIATKFIPRTQEeieqgidaKQHIENCLNGSLKR 117
Cdd:cd19137    26 EEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDF-PREDLFIVTKVWPTNLR--------YDDLLRSLQNSLRR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 118 LDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIakanEIAKAKGYEQFVSIQGHYNLIFRE-EE 196
Cdd:cd19137    97 LDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLL----EEAISKSQTPIVCNQVKYNLEDRDpER 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 197 REMKQYCVAHNIAMTPYSALASGRLAKhpgeesKRLsediyakgkydithdedlaiihrVEELAEKKGVSMTEISLAWLL 276
Cdd:cd19137   173 DGLLEYCQKNGITVVAYSPLRRGLEKT------NRT-----------------------LEEIAKNYGKTIAQIALAWLI 223
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1797152346 277 TK---VTSPIigATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19137   224 QKpnvVAIPK--AGRVEHLKENLKATEIKLSEEEM 256
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
1-301 2.40e-35

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 130.55  E-value: 2.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSkvclgCMGFGeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIK 75
Cdd:cd19159     1 MKYRNLGKSGLRVS-----CLGLG-------TWVtfggqISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIK 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  76 EYA-KREDVIIATKFIPRTQEEIEQGIdAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVR 154
Cdd:cd19159    69 KKGwRRSSLVITTKLYWGGKAETERGL-SRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAM 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 155 YIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLiFREEEREMKQYCVAHNI---AMTpYSALASGRLAKHPGE---E 228
Cdd:cd19159   148 YWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHL-FQREKVEVQLPELYHKIgvgAMT-WSPLACGIISGKYGNgvpE 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 229 SKRLSEDIYAKGKYDITHDEDLAIIHRVEEL---AEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAV 301
Cdd:cd19159   226 SSRASLKCYQWLKERIVSEEGRKQQNKLKDLspiAERLGCTLPQLAVAWCLRNegVSSVLLGSSTPEQLIENLGAIQV 303
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
22-298 3.66e-35

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 128.12  E-value: 3.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  22 GFGEAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYAkREDVIIATKfiprTQEEIEQGI 101
Cdd:cd19095     4 GLGTSGIGRVWGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGLR-RDDLFIATK----VGTHGEGGR 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 102 DAKQ----HIENCLNGSLKRLDMDYVDLYILHM---WDYNtpiEDIMAALHDVIRQGKVRYIGISNcyawqiaKANEIAK 174
Cdd:cd19095    77 DRKDfspaAIRASIERSLRRLGTDYIDLLQLHGpsdDELT---GEVLETLEDLKAAGKVRYIGVSG-------DGEELEA 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 175 AKGYEQFVSIQGHYNLIFREEEREMKQycvAHN-----IAMTPysaLASGRLakHPGEESKRLSEDIYAkgkydithded 249
Cdd:cd19095   147 AIASGVFDVVQLPYNVLDREEEELLPL---AAEaglgvIVNRP---LANGRL--RRRVRRRPLYADYAR----------- 207
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 250 laiihRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKA 298
Cdd:cd19095   208 -----RPEFAAEIGGATWAQAALRFVLSHpgVSSAIVGTTNPEHLEENLAA 253
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
14-235 7.14e-35

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 127.29  E-value: 7.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGEAQKGmhswTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIATKFIPRT 93
Cdd:cd19096     1 SVLGFGTMRLPESDDD----SIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEG-PREKFYLATKLPPWS 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  94 QEEIEqgiDAKQHIENclngSLKRLDMDYVDLYILHM-----WDYNTPIEDIMAALHDVIRQGKVRYIGISNCyawqiAK 168
Cdd:cd19096    76 VKSAE---DFRRILEE----SLKRLGVDYIDFYLLHGlnspeWLEKARKGGLLEFLEKAKKEGLIRHIGFSFH-----DS 143
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 169 ANEIAKAKGYEQFVSIQGHYNLIFREEEREMK--QYCVAHN---IAMTPysaLASGRLAKHPGEESKRLSED 235
Cdd:cd19096   144 PELLKEILDSYDFDFVQLQYNYLDQENQAGRPgiEYAAKKGmgvIIMEP---LKGGGLANNPPEALAILCGA 212
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
1-308 3.77e-32

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 121.12  E-value: 3.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGeaqkGMHsWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEyAKR 80
Cdd:cd19163     1 MKYRKLGKTGLKVSKLGFGASPLG----GVF-GPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKG-IPR 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  81 EDVIIATKfIPRTQEEIEQGID-AKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIM----AALHDVIRQGKVRY 155
Cdd:cd19163    75 DSYYLATK-VGRYGLDPDKMFDfSAERITKSVEESLKRLGLDYIDIIQVHDIEFAPSLDQILnetlPALQKLKEEGKVRF 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 156 IGISNcYAWQIAKaNEIAKAKGYEQFVSIQGHYNLIFREEEREMkQYCVAHNIAMTPYSALASGRLAK------HPGees 229
Cdd:cd19163   154 IGITG-YPLDVLK-EVLERSPVKIDTVLSYCHYTLNDTSLLELL-PFFKEKGVGVINASPLSMGLLTErgppdwHPA--- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 230 krlsediyakgkyditHDEDLAIIHRVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLTDEE 307
Cdd:cd19163   228 ----------------SPEIKEACAKAAAYCKSRGVDISKLALQFALsnPDIATTLVGTASPENLRKNLEAAEEPLDAHL 291

                  .
gi 1797152346 308 I 308
Cdd:cd19163   292 L 292
tas PRK10625
putative aldo-keto reductase; Provisional
1-316 6.73e-32

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 121.88  E-value: 6.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCMGFGEAQKgmhswtlpYEESKKIIKYALDNGINFFDTAIGY--------QGGTsEAFLGK 72
Cdd:PRK10625    1 MQYHRIPHSSLEVSTLGLGTMTFGEQNS--------EADAHAQLDYAVAQGINLIDVAEMYpvpprpetQGLT-ETYIGN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  73 AIKEYAKREDVIIATKF---IPRTQEEI--EQGIDAKqHIENCLNGSLKRLDMDYVDLYILH--------------MWDY 133
Cdd:PRK10625   72 WLAKRGSREKLIIASKVsgpSRNNDKGIrpNQALDRK-NIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgySWTD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 134 NTPIE---DIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLIFREEE---REMKQYcvaHN 207
Cdd:PRK10625  151 SAPAVsllETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEvglAEVSQY---EG 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 208 IAMTPYSALASGRL-------AKHPGEESKRLSEDIyakgKYDITHDEdLAIIHRVeELAEKKGVSMTEISLAWLLTK-- 278
Cdd:PRK10625  228 VELLAYSCLAFGTLtgkylngAKPAGARNTLFSRFT----RYSGEQTQ-KAVAAYV-DIAKRHGLDPAQMALAFVRRQpf 301
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1797152346 279 VTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYK 316
Cdd:PRK10625  302 VASTLLGATTMEQLKTNIESLHLTLSEEVLAEIEAVHQ 339
AKR_AKR14A1 cd19150
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ...
3-308 1.48e-31

Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.


Pssm-ID: 381376 [Multi-domain]  Cd Length: 309  Bit Score: 120.25  E-value: 1.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSKVCLGC-MGFGEAQkgmhswtlPYEESKKIIKYALDNGINFFDTAIGY--QGGTSEAFLGKAIKE--Y 77
Cdd:cd19150     2 YRRCGKSGLKLPALSLGLwHNFGDDT--------PLETQRAILRTAFDLGITHFDLANNYgpPPGSAEENFGRILREdfA 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  78 AKREDVIIATKfiprtqeeieQGID----------AKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDV 147
Cdd:cd19150    74 GYRDELIISTK----------AGYDmwpgpygewgSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHA 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 148 IRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQFVSiQGHYNLIFR-EEEREMKQYCVAHNIAMTPYSALASGRLA-KHP 225
Cdd:cd19150   144 VRSGKALYVGISSYSPERTREAAAILRELGTPLLIH-QPSYNMLNRwVEESGLLDTLQELGVGCIAFTPLAQGLLTdKYL 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 226 G--EESKRLSEDIYAKGKyDIThDEDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAV-A 300
Cdd:cd19150   223 NgiPEGSRASKERSLSPK-MLT-EANLNSIRALNEIAQKRGQSLAQMALAWVLRDgrVTSALIGASRPEQLEENVGALdN 300

                  ....*...
gi 1797152346 301 VKLTDEEI 308
Cdd:cd19150   301 LTFSADEL 308
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
1-290 1.99e-31

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 120.26  E-value: 1.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGcmgfgeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIK 75
Cdd:cd19142     1 LKYRNLGKSGLRVSNVGLG------------TWStfstaISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILK 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  76 EYA-KREDVIIATKFIPRTQEEiEQGIDAKqHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVR 154
Cdd:cd19142    69 KKGwKRSSYIVSTKIYWSYGSE-ERGLSRK-HIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIM 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 155 YIGISNCYAWQIAKANEIAKakgyeQFVSI-----QGHYNLIFREE-EREMKQYCVAHNIAMTPYSALASGRLAKHPGEE 228
Cdd:cd19142   147 YWGTSRWSPVEIMEAFSIAR-----QFNCPtpiceQSEYHMFCREKmELYMPELYNKVGVGLITWSPLSLGLDPGISEET 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1797152346 229 SKRLSEDIYAKGKYDI------THDEDLAIIHRVEEL---AEKKGVSMTEISLAWLLTK--VTSPIIGATKPH 290
Cdd:cd19142   222 RRLVTKLSFKSSKYKVgsdgngIHEETRRASHKLRELsliAERLGCDLTQLLIAWSLKNenVQCVLIGASSLE 294
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
1-287 2.14e-31

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 120.09  E-value: 2.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSkvclgCMGFGeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIK 75
Cdd:cd19160     3 MKYRNLGKSGLRVS-----CLGLG-------TWVtfgsqISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILK 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  76 EYA-KREDVIIATKFIPRTQEEIEQGIdAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVR 154
Cdd:cd19160    71 SKGwRRSSYVVTTKIYWGGQAETERGL-SRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAM 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 155 YIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLiFREEEREMKQYCVAHNI---AMTpYSALASGRL-AKHPGE--E 228
Cdd:cd19160   150 YWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHL-FQREKVEMQLPELYHKIgvgSVT-WSPLACGLItGKYDGRvpD 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 229 SKRLSEDIYAKGKYDITHDEDLAIIHRVEEL---AEKKGVSMTEISLAWLLTK--VTSPIIGAT 287
Cdd:cd19160   228 TCRAAVKGYQWLKEKVQSEEGKKQQAKVKELhpiADRLGCTVAQLAIAWCLRSegVSSVLLGVS 291
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
29-320 8.11e-31

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 117.60  E-value: 8.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKFIP--RTQEEIEQGi 101
Cdd:cd19111     8 GLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQ---NEKAIGEALKWWlkngkLKREEVFITTKLPPvyLEFKDTEKS- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 102 dakqhiencLNGSLKRLDMDYVDLYILHM-WDYN------------TPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAK 168
Cdd:cd19111    84 ---------LEKSLENLKLPYVDLYLIHHpCGFVnkkdkgerelasSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 169 ANEIAKAKGYeqfvSIQGHYNLIFreEEREMKQYCVAHNIAMTPYSALASgrlakhPGEESKRLSEDiyakgKYDITHDE 248
Cdd:cd19111   155 ILAYAKVKPS----NLQLECHAYL--QQRELRKFCNKKNIVVTAYAPLGS------PGRANQSLWPD-----QPDLLEDP 217
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 249 dlaiihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:cd19111   218 ------TVLAIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
1-313 1.33e-30

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 118.55  E-value: 1.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSKVCLGCM-GFGEAQkgmhswtlPYEESKKIIKYALDNGINFFDTAIGY--QGGTSEAFLGKAIKE- 76
Cdd:PRK09912   13 MQYRYCGKSGLRLPALSLGLWhNFGHVN--------ALESQRAILRKAFDLGITHFDLANNYgpPPGSAEENFGRLLREd 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  77 -YAKREDVIIATKfiprtqeeieQGID----------AKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALH 145
Cdd:PRK09912   85 fAAYRDELIISTK----------AGYDmwpgpygsggSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 146 DVIRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQFVSiQGHYNLIFREEEREMKQYCVAHN----IAMTPYS-ALASGR 220
Cdd:PRK09912  155 HAVQSGKALYVGISSYSPERTQKMVELLREWKIPLLIH-QPSYNLLNRWVDKSGLLDTLQNNgvgcIAFTPLAqGLLTGK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 221 LAKHPGEESKRLSEDIYAKG-KYDITHDEDLAIIHRVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVK 297
Cdd:PRK09912  234 YLNGIPQDSRMHREGNKVRGlTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLkdERVTSVLIGASRAEQLEENVQ 313
                         330
                  ....*....|....*..
gi 1797152346 298 AVA-VKLTDEEIIYLEE 313
Cdd:PRK09912  314 ALNnLTFSTEELAQIDQ 330
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
29-320 1.05e-29

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 115.20  E-value: 1.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKFIPrtqeeieqGIDA 103
Cdd:cd19154    16 GLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQ---NEEAIGEALAELleegvVKREDLFITTKLWT--------HEHA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 KQHIENCLNGSLKRLDMDYVDLYILHM-W-------DYNT-----------PIEDIMAALHDVIRQGKVRYIGISNCYAW 164
Cdd:cd19154    85 PEDVEEALRESLKKLQLEYVDLYLIHApAafkddegESGTmengmsihdavDVEDVWRGMEKVYDEGLTKAIGVSNFNND 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 165 QIAKANEIAKAKGYEQFVSIQGHYnlifreEEREMKQYCVAHNIAMTPYSALASgrlakhPGEESKRLSeDIYAKGKYDI 244
Cdd:cd19154   165 QIQRILDNARVKPHNNQVECHLYF------PQKELVEFCKKHNISVTSYATLGS------PGRANFTKS-TGVSPAPNLL 231
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1797152346 245 THDedlaiihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:cd19154   232 QDP-------IVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRL 300
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
20-314 1.29e-29

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 113.51  E-value: 1.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  20 CMGFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-AKREDVIIATKFIP---RTQe 95
Cdd:cd19140    10 ALGLG-------TYPLTGEECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIAASgVPRDELFLTTKVWPdnySPD- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  96 eieqgiDAKQHIENclngSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKA 175
Cdd:cd19140    79 ------DFLASVEE----SLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEA 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 176 KgyeqFVSIQGHYNLIFReeEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihR 255
Cdd:cd19140   149 P----LFTNQVEYHPYLD--QRKLLDAAREHGIALTAYSPLARGEVLKDP-----------------------------V 193
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 256 VEELAEKKGVSMTEISLAWLLTKVTSPII-GATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19140   194 LQEIGRKHGKTPAQVALRWLLQQEGVAAIpKATNPERLEENLDIFDFTLSDEEMARIAAL 253
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
29-320 5.72e-29

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 113.00  E-value: 5.72e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKfIPRTQEEIEQgida 103
Cdd:cd19155    16 GLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYR---NEAAIGNVLKKWidsgkVKREELFIVTK-LPPGGNRREK---- 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 kqhIENCLNGSLKRLDMDYVDLYILHM---------------------WDYNTPIEDIMAALHDVIRQGKVRYIGISNCY 162
Cdd:cd19155    88 ---VEKFLLKSLEKLQLDYVDLYLIHFpvgslskeddsgkldptgehkQDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFN 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 163 AWQIAKANEIAKAKGyeqfVSIQGHYNLIFreEEREMKQYCVAHNIAMTPYSALASGRLAKhpgeeskrlsediYAKGKY 242
Cdd:cd19155   165 REQMARILKNARIKP----ANLQVELHVYL--QQKDLVDFCSTHSITVTAYAPLGSPGAAH-------------FSPGTG 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 243 DITHDE-DLAIIHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:cd19155   226 SPSGSSpDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRG 304
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
38-297 6.71e-29

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 113.18  E-value: 6.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEY-----AKREDVIIATK--FIP-------RTQEEIEQGIDA 103
Cdd:cd19099    21 EEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekggIKRDEVVIVTKagYIPgdgdeplRPLKYLEEKLGR 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 KQ----------------HIENCLNGSLKRLDMDYVDLYILH----------MWDYNTPIEDIMAALHDVIRQGKVRYIG 157
Cdd:cd19099   101 GLidvadsaglrhcispaYLEDQIERSLKRLGLDTIDLYLLHnpeeqllelgEEEFYDRLEEAFEALEEAVAEGKIRYYG 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 158 ISnCYAWQIA-----------KANEIAKAKGYE--QFVSIQGHYNLIFREEEREMK----------QYCVAHNIAMTPYS 214
Cdd:cd19099   181 IS-TWDGFRAppalpghlsleKLVAAAEEVGGDnhHFKVIQLPLNLLEPEALTEKNtvkgealsllEAAKELGLGVIASR 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 215 ALASGRLAKhpgeeskrlsediyakgkydithdedlaIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHI 292
Cdd:cd19099   260 PLNQGQLLG----------------------------ELRLADLLALPGGATLAQRALQFARSTpgVDSALVGMRRPEHV 311

                  ....*
gi 1797152346 293 DGAVK 297
Cdd:cd19099   312 DENLA 316
AKR_KCAB2B_AKR6A1-like cd19158
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ...
1-301 8.50e-29

voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.


Pssm-ID: 381384 [Multi-domain]  Cd Length: 324  Bit Score: 113.26  E-value: 8.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSkvclgCMGFGeaqkgmhSWT-----LPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIK 75
Cdd:cd19158     1 QFYRNLGKSGLRVS-----CLGLG-------TWVtfggqITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  76 EYA-KREDVIIATKFIPRTQEEIEQGIdAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDVIRQGKVR 154
Cdd:cd19158    69 KKGwRRSSLVITTKIFWGGKAETERGL-SRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAM 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 155 YIGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYNLiFREEEREMKQYCVAHNI---AMTpYSALASGRLAKHPGE---E 228
Cdd:cd19158   148 YWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHM-FQREKVEVQLPELFHKIgvgAMT-WSPLACGIVSGKYDSgipP 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 229 SKRLSEDIYAKGKYDITHDE---DLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAV 301
Cdd:cd19158   226 YSRASLKGYQWLKDKILSEEgrrQQAKLKELQAIAERLGCTLPQLAIAWCLRNegVSSVLLGASNAEQLMENIGAIQV 303
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
14-191 6.34e-27

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 106.46  E-value: 6.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCmgfgeAQKGM------HSWTLPYEESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYakrEDVIIAT 87
Cdd:cd19097     1 SKLALGT-----AQFGLdygianKSGKPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLKRL---DKFKIIT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  88 KfIPRTQEEIEqgiDAKQHIENCLNGSLKRLDMDYVDLYILHMW-DYNTPIEDIMAALHDVIRQGKVRYIGISnCYAWqi 166
Cdd:cd19097    71 K-LPPLKEDKK---EDEAAIEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVS-VYSP-- 143
                         170       180
                  ....*....|....*....|....*
gi 1797152346 167 akaNEIAKAKGYEQFVSIQGHYNLI 191
Cdd:cd19097   144 ---EELEKALESFKIDIIQLPFNIL 165
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
20-314 7.55e-25

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 101.45  E-value: 7.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  20 CMGFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPrTQ 94
Cdd:cd19128     3 RLGFG-------TYKITESESKEAVKNAIKAGYRHIDCAYYYG---NEAFIGIAFSEifkdgGVKREDLFITSKLWP-TM 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  95 EEIEQgidakqhIENCLNGSLKRLDMDYVDLYILH---MWDYNT----------------PIEDIMAALHDVIRQGKVRY 155
Cdd:cd19128    72 HQPEN-------VKEQLLITLQDLQLEYLDLFLIHwplAFDMDTdgdprddnqiqslskkPLEDTWRAMEQCVDEKLTKN 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 156 IGISNCYAWQIAKANEIAKAKGYEQFVSIQGHYnlifrEEEREMKqYCVAHNIAMTPYSALAsGRlakhpgeeskrlsed 235
Cdd:cd19128   145 IGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYF-----QNDKLIK-FCIENNIHVTAYRPLG-GS--------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 236 iYAKGKYDITHDEDLaiihrvEELAEKKGVSMTEISLAWLLTKVT---SPIIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:cd19128   203 -YGDGNLTFLNDSEL------KALATKYNTTPPQVIIAWHLQKWPknySVIPKSANKSRCQQNFDINDLALTKEDMDAIN 275

                  ..
gi 1797152346 313 EL 314
Cdd:cd19128   276 TL 277
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
46-314 1.44e-23

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 97.39  E-value: 1.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  46 YAL-DNGINFFDTAIGYqgGTsEAFLGKAIKEYA-KREDVIIATKFIPrTQEEIEQGIDAKQhienclnGSLKRLDMDYV 123
Cdd:cd19135    33 YALkECGYRHIDTAKRY--GC-EELLGKAIKESGvPREDLFLTTKLWP-SDYGYESTKQAFE-------ASLKRLGVDYL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 124 DLYILHMWDYNTPIEDIMAALHDVIR-------QGKVRYIGISNcyaWQIAKANEIakakgyEQFVSIQGHYNL----IF 192
Cdd:cd19135   102 DLYLLHWPDCPSSGKNVKETRAETWRaleelydEGLCRAIGVSN---FLIEHLEQL------LEDCSVVPHVNQvefhPF 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 193 REEErEMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEKKGVSMTEISL 272
Cdd:cd19135   173 QNPV-ELIEYCRDNNIVFEGYCPLAKGKALEEP-----------------------------TVTELAKKYQKTPAQILI 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1797152346 273 AWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19135   223 RWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
36-321 4.24e-22

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 93.89  E-value: 4.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  36 PYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKFiprtqeeieQGIDAKQH-IEN 109
Cdd:cd19116    23 DDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREKiaegvVKREDLFITTKL---------WNSYHEREqVEP 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 110 CLNGSLKRLDMDYVDLYILHM-------WDYNTPIE---------DIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIA 173
Cdd:cd19116    91 ALRESLKRLGLDYVDLYLIHWpvafkenNDSESNGDgslsdidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNC 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 174 KAK-GYEQfvsIQGHYNLIfreeEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSEdiyakgkydithdedlai 252
Cdd:cd19116   171 NIKpAVNQ---IEVHPTLT----QEKLVAYCQSNGIVVMAYSPFGRLVPRGQTNPPPRLDDP------------------ 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 253 ihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRLV 321
Cdd:cd19116   226 --TLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
29-314 7.02e-22

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 92.42  E-value: 7.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFiprtqeeieqgidakqHI 107
Cdd:cd19139     5 GLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYD---NEAAVGQAIAESGvPRDELFITTKI----------------WI 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 108 EN--------CLNGSLKRLDMDYVDLYILHmW---DYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAkak 176
Cdd:cd19139    66 DNlskdkllpSLEESLEKLRTDYVDLTLIH-WpspNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVV--- 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 177 GYEQFVSIQGHYNLIFreEEREMKQYCVAHNIAMTPYSALASGRLAKhpgeeskrlsediyakgkydithDEDLAIIhrv 256
Cdd:cd19139   142 GAGAIATNQIELSPYL--QNRKLVAHCKQHGIHVTSYMTLAYGKVLD-----------------------DPVLAAI--- 193
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 257 eelAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19139   194 ---AERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
38-306 8.18e-22

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 93.44  E-value: 8.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYAkREDVIIATK----FIPRTQEE------IEQGIDAK--- 104
Cdd:cd19152    20 EEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG-REDYVISTKvgrlLVPLQEVEptfepgFWNPLPFDavf 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 105 ----QHIENCLNGSLKRLDMDYVDLYILHMWDYNTP-----------IEDIMAALHDVIRQGKVRYIGI-SNcyAWQIA- 167
Cdd:cd19152    99 dysyDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAgaesdehfaqaIKGAFRALEELREEGVIKAIGLgVN--DWEVIl 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 168 KANEIAKAkgyeQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAkhpgeeskrlSEDIYAKGKYDITHD 247
Cdd:cd19152   177 RILEEADL----DWVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLA----------GGDNFDYYEYGPAPP 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 248 EDLAIIHRVEELAEKKGVSMTEISLAWLLTK--VTSPIIGATKPHHIDGAVKAVAVKLTDE 306
Cdd:cd19152   243 ELIARRDRIEALCEQHGVSLAAAALQFALAPpaVASVAPGASSPERVEENVALLATEIPAA 303
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
1-321 1.79e-21

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 92.47  E-value: 1.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   1 MEYVKLGDSDLMVSkvclgcMGFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAI-----K 75
Cdd:cd19123     1 MKTLPLSNGDLIPA------LGLG-------TWKSKPGEVGQAVKQALEAGYRHIDCAAIYG---NEAEIGAALaevfkE 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  76 EYAKREDVIIATKFIPRTQeeieqgidAKQHIENCLNGSLKRLDMDYVDLYILHmW---------------DY----NTP 136
Cdd:cd19123    65 GKVKREDLWITSKLWNNSH--------APEDVLPALEKTLADLQLDYLDLYLMH-WpvalkkgvgfpesgeDLlslsPIP 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 137 IEDIMAALHDVIRQGKVRYIGISNCYAWQIAKAneIAKAKGYEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSAL 216
Cdd:cd19123   136 LEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDL--LATARIKPAVNQVELHPYL----QQPELLAFCRDNGIHLTAYSPL 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 217 ASG-RLAKHPGEESKRLSEDiyakgkydithdedlAIIhrvEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGA 295
Cdd:cd19123   210 GSGdRPAAMKAEGEPVLLED---------------PVI---NKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQN 271
                         330       340
                  ....*....|....*....|....*.
gi 1797152346 296 VKAVAVKLTDEEIIYLEELYKPHRLV 321
Cdd:cd19123   272 LEAAEVELDASDMATIAALDRHHRYV 297
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
37-314 2.67e-21

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 91.15  E-value: 2.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  37 YEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPRtqeeiEQGIDAKQhieNCL 111
Cdd:cd19136    14 EEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRDllpkyGLSREDIFITSKLAPK-----DQGYEKAR---AAC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 112 NGSLKRLDMDYVDLYILHmWD--YNTPIEDIM---------AALHDVIRQGKVRYIGISNcYawqiakanEIAKAKGYEQ 180
Cdd:cd19136    83 LGSLERLGTDYLDLYLIH-WPgvQGLKPSDPRnaelrreswRALEDLYKEGKLRAIGVSN-Y--------TVRHLEELLK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 181 FVSIQGHYNLI-F--REEEREMKQYCVAHNIAMTPYSALASGRLakhpgeesKRLSEDiyakgkydithdedlaiihRVE 257
Cdd:cd19136   153 YCEVPPAVNQVeFhpHLVQKELLKFCKDHGIHLQAYSSLGSGDL--------RLLEDP-------------------TVL 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 258 ELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19136   206 AIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
21-306 1.53e-20

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 89.73  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGEAQKGMHSwTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIATK---FIPRTQEEI 97
Cdd:cd19162     3 LGLGAASLGNLA-RAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARH-PRAEYVVSTKvgrLLEPGAAGR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  98 EQGIDAKQH-----IENCLNGSLKRLDMDYVDLYILHMWD--YNTPIEDIMAALHDVIRQGKVRYIGISnCYAWQIAKAn 170
Cdd:cd19162    81 PAGADRRFDfsadgIRRSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVG-VTDWAALLR- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 171 eiAKAKGYEQFVSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEeskrlsEDIYakgKYDITHDEDL 250
Cdd:cd19162   159 --AARRADVDVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDPA------GDRY---DYRPATPEVL 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1797152346 251 AIIHRVEELAEKKGVSMTEISLAWLL--TKVTSPIIGATKPHHIDGAVKAVAVKLTDE 306
Cdd:cd19162   228 ARARRLAAVCRRYGVPLPAAALQFPLrhPAVASVVVGAASPAELRDNLALLRTPIPAE 285
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
29-321 1.71e-20

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 89.75  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYqggTSEAFLGKAIKE------YAKREDVIIATKFIprtqeeieqgiD 102
Cdd:cd19106    11 GLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVY---GNEQEVGEALKEkvgpgkAVPREDLFVTSKLW-----------N 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 103 AKQH---IENCLNGSLKRLDMDYVDLYILHmWDY--------------------NTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19106    77 TKHHpedVEPALRKTLKDLQLDYLDLYLIH-WPYafergdnpfpknpdgtirydSTHYKETWKAMEKLVDKGLVKAIGLS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NCYAWQIAKANEIAKAKGYEQFVSIQGHYNlifreeEREMKQYCVAHNIAMTPYSALAS-GRLAKHPGEESkrLSEDiya 238
Cdd:cd19106   156 NFNSRQIDDILSVARIKPAVLQVECHPYLA------QNELIAHCKARGLVVTAYSPLGSpDRPWAKPDEPV--LLEE--- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 239 kgkydithdedlaiiHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPH 318
Cdd:cd19106   225 ---------------PKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNW 289

                  ...
gi 1797152346 319 RLV 321
Cdd:cd19106   290 RYI 292
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
38-319 5.43e-20

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 87.83  E-value: 5.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYAK-REDVIIATKFIprtqeeieqgiDAKQHIENCL---NG 113
Cdd:cd19157    24 SEVVNAVKTALKNGYRSIDTAAIYG---NEEGVGKGIKESGIpREELFITSKVW-----------NADQGYDSTLkafEA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 114 SLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIRQGKVRYIGISNcyaWQIAKANEI-AKAKGYEQFVSIQGHYNLIf 192
Cdd:cd19157    90 SLERLGLDYLDLYLIH-WPVKGKYKETWKALEKLYKDGRVRAIGVSN---FQVHHLEDLlADAEIVPMVNQVEFHPRLT- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 193 reeEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEKKGVSMTEISL 272
Cdd:cd19157   165 ---QKELRDYCKKQGIQLEAWSPLMQGQLLDNP-----------------------------VLKEIAEKYNKSVAQVIL 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1797152346 273 AWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHR 319
Cdd:cd19157   213 RWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLR 259
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
27-225 1.46e-19

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 86.27  E-value: 1.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  27 QKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFiprtqEEIEQGIDAKq 105
Cdd:cd19131    12 QLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRASGvPREELFITTKL-----WNSDQGYDST- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 106 hiENCLNGSLKRLDMDYVDLYILHmWDynTPIEDIMA----ALHDVIRQGKVRYIGISNcyaWQIAKANEIAKAKGYEQF 181
Cdd:cd19131    83 --LRAFDESLRKLGLDYVDLYLIH-WP--VPAQDKYVetwkALIELKKEGRVKSIGVSN---FTIEHLQRLIDETGVVPV 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1797152346 182 VS-IQGHYnlifREEEREMKQYCVAHNIAMTPYSALASGRLAKHP 225
Cdd:cd19131   155 VNqIELHP----RFQQRELRAFHAKHGIQTESWSPLGQGGLLSDP 195
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
29-308 9.37e-19

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 84.03  E-value: 9.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPY-EESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFIPRTQEEiEQGIDAKQH 106
Cdd:cd19126    13 GLGVFQTPDgDETERAVQTALENGYRSIDTAAIYK---NEEGVGEAIRESGvPREELFVTTKLWNDDQRA-RRTEDAFQE 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 107 ienclngSLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIRQGKVRYIGISNcyaWQIAKANEIAKAKGYEQFVS-IQ 185
Cdd:cd19126    89 -------SLDRLGLDYVDLYLIH-WPGKDKFIDTWKALEKLYASGKVKAIGVSN---FQEHHLEELLAHADVVPAVNqVE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 186 GHYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEKKGV 265
Cdd:cd19126   158 FHPYL----TQKELRGYCKSKGIVVEAWSPLGQGGLLSNP-----------------------------VLAAIGEKYGK 204
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1797152346 266 SMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19126   205 SAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDM 247
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
44-321 1.98e-18

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 83.53  E-value: 1.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  44 IKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATK----------FIPRTQEeieqgidakqhiencln 112
Cdd:PRK11172   22 VKTALELGYRAIDTAQIYD---NEAAVGQAIAESGvPRDELFITTKiwidnlakdkLIPSLKE----------------- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 113 gSLKRLDMDYVDLYILHmW---DYNTPIEDIMAALHDVIRQGKVRYIGISNcyaWQIAKANEIAKAKGYEQFVS--IQGH 187
Cdd:PRK11172   82 -SLQKLRTDYVDLTLIH-WpspNDEVSVEEFMQALLEAKKQGLTREIGISN---FTIALMKQAIAAVGAENIATnqIELS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 188 YNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEKKGVSM 267
Cdd:PRK11172  157 PYL----QNRKVVAFAKEHGIHVTSYMTLAYGKVLKDP-----------------------------VIARIAAKHNATP 203
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 268 TEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRLV 321
Cdd:PRK11172  204 AQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGRLV 257
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
38-319 2.27e-18

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 83.70  E-value: 2.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKFIPRTQEeieqgidakqHIENCLN 112
Cdd:cd19119    27 AEVKEAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRAiddgsIKREELFITTKVWPTFYD----------EVERSLD 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 113 GSLKRLDMDYVDLYILH-------------------------MWDYNTPIEDIMAALHDVIRQGKVRYIGISNcyaWQIA 167
Cdd:cd19119    94 ESLKALGLDYVDLLLVHwpvcfekdsddsgkpftpvnddgktRYAASGDHITTYKQLEKIYLDGRAKAIGVSN---YSIV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 168 KANEIAKAKGYEQFVS-IQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPGEEskrlsediyakgkydith 246
Cdd:cd19119   171 YLERLIKECKVVPAVNqVELHPHL----PQMDLRDFCFKHGILVTAYSPLGSHGAPNLKNPL------------------ 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 247 dedlaiihrVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAvkLTDEEIIYLEELY--KPHR 319
Cdd:cd19119   229 ---------VKKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKIVS--LTKEDLQKLDDIGekYPVR 292
PLN02587 PLN02587
L-galactose dehydrogenase
3-159 2.69e-18

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 83.67  E-value: 2.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   3 YVKLGDSDLMVSkvclgCMGFGEAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYA-KRE 81
Cdd:PLN02587    1 LRELGSTGLKVS-----SVGFGASPLGSVFGPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGiPRE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  82 DVIIATKfIPRTQEeieqGID-AKQHIENCLNGSLKRLDMDYVDlyILHMWD-----YNTPIEDIMAALHDVIRQGKVRY 155
Cdd:PLN02587   76 KYVVSTK-CGRYGE----GFDfSAERVTKSVDESLARLQLDYVD--ILHCHDiefgsLDQIVNETIPALQKLKESGKVRF 148

                  ....
gi 1797152346 156 IGIS 159
Cdd:PLN02587  149 IGIT 152
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
27-320 3.14e-18

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 82.95  E-value: 3.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  27 QKGMHSWTLPY-EESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFIprtqeeieqgiDAK 104
Cdd:cd19156    11 RLGLGVWRVQDgAEAENAVKWAIEAGYRHIDTAAIYK---NEEGVGQGIRESGvPREEVFVTTKLW-----------NSD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 105 QHIENCLNG---SLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAKAKGYEQF 181
Cdd:cd19156    77 QGYESTLAAfeeSLEKLGLDYVDLYLIH-WPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 182 VSIQGHYNlifreeEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAE 261
Cdd:cd19156   156 IELHPLLT------QEPLRKFCKEKNIAVEAWSPLGQGKLLSNP-----------------------------VLKAIGK 200
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 262 KKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:cd19156   201 KYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRY 259
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
36-308 1.48e-17

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 80.70  E-value: 1.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  36 PYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKFIPR--TQEEIEQGIDAkqhiencln 112
Cdd:cd19133    21 DPEECERAVLEAIKAGYRLIDTAAAYG---NEEAVGRAIKKSGiPREELFITTKLWIQdaGYEKAKKAFER--------- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 113 gSLKRLDMDYVDLYILHmWDYNtpiEDIMA--ALHDVIRQGKVRYIGISNCYAWQIA---KANEIAKAkgyeqfVS-IQG 186
Cdd:cd19133    89 -SLKRLGLDYLDLYLIH-QPFG---DVYGAwrAMEELYKEGKIRAIGVSNFYPDRLVdliLHNEVKPA------VNqIET 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 187 HYNLIFREEEREMKQYcvahNIAMTPYSALASGRlakhpgeeskrlsediyakgkYDITHDEDLAiihrveELAEKKGVS 266
Cdd:cd19133   158 HPFNQQIEAVEFLKKY----GVQIEAWGPFAEGR---------------------NNLFENPVLT------EIAEKYGKS 206
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1797152346 267 MTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19133   207 VAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDM 248
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
38-307 1.48e-16

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 78.46  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  38 EESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE------YAKREDVIIATKFIPRtqeeieqgiDA-KQHIENC 110
Cdd:cd19124    20 EDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEalrlglVKSRDELFVTSKLWCS---------DAhPDLVLPA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 111 LNGSLKRLDMDYVDLYILHmW-------DYNTPI--EDIM--------AALHDVIRQGKVRYIGISNCYAWQIAKANEIA 173
Cdd:cd19124    88 LKKSLRNLQLEYVDLYLIH-WpvslkpgKFSFPIeeEDFLpfdikgvwEAMEECQRLGLTKAIGVSNFSCKKLQELLSFA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 174 KakgyeqfvsI-----QGHYNLIFReeEREMKQYCVAHNIAMTPYSALasGRLAKHPGeeSKRLSEDiyakgkydithde 248
Cdd:cd19124   167 T---------IppavnQVEMNPAWQ--QKKLREFCKANGIHVTAYSPL--GAPGTKWG--SNAVMES------------- 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 249 dlAIIHrveELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEE 307
Cdd:cd19124   219 --DVLK---EIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEED 272
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
22-308 1.57e-16

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 77.70  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  22 GFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKfIPRTQEEIEQG 100
Cdd:cd19132    11 GFG-------TYPLKGDEGVEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRSGvPREELFVTTK-LPGRHHGYEEA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 101 IDakqhienCLNGSLKRLDMDYVDLYILHmWDynTPIEDIMA----ALHDVIRQGKVRYIGISNCYAWQIakaNEIAKAK 176
Cdd:cd19132    80 LR-------TIEESLYRLGLDYVDLYLIH-WP--NPSRDLYVeawqALIEAREEGLVRSIGVSNFLPEHL---DRLIDET 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 177 GYEQFVS-IQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGrlakhpgeeSKRLSEDIyakgkydithdedlaiihr 255
Cdd:cd19132   147 GVTPAVNqIELHPYF----PQAEQRAYHREHGIVTQSWSPLGRG---------SGLLDEPV------------------- 194
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1797152346 256 VEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19132   195 IKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDM 247
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
5-159 5.30e-16

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 77.19  E-value: 5.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   5 KLGDSDLMVSKVCLGCMGFGeaqkGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEY-AKREDV 83
Cdd:cd19153     4 TLEIALGNVSPVGLGTAALG----GVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALqVPRSSY 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346  84 IIATKFIPRTQEEIEQGIDAkqhIENCLNGSLKRLDMDYVDLYILH---MWDYNTPIEDIMAALHDVIRQGKVRYIGIS 159
Cdd:cd19153    80 TVATKVGRYRDSEFDYSAER---VRASVATSLERLHTTYLDVVYLHdieFVDYDTLVDEALPALRTLKDEGVIKRIGIA 155
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
29-314 9.01e-16

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 76.03  E-value: 9.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY----AKREDVIIATKFIPRTQEEIEQGIDAk 104
Cdd:cd19121    16 GLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQ---NEDEVGEGIKEAiaggVKREDLFVTTKLWSTYHRRVELCLDR- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 105 qhienclngSLKRLDMDYVDLYILH------------------------MWDYNTPieDIMAALHDVIRQGKVRYIGISN 160
Cdd:cd19121    92 ---------SLKSLGLDYVDLYLVHwpvllnpngnhdlfptlpdgsrdlDWDWNHV--DTWKQMEKVLKTGKTKAIGVSN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 161 C---YAWQIAKANEIAKAKGyeqfvSIQGHYNLifreEEREMKQYCVAHNIAMTPYSALASgrlakhpgEESKRLSEDiy 237
Cdd:cd19121   161 YsipYLEELLKHATVVPAVN-----QVENHPYL----PQQELVDFCKEKGILIEAYSPLGS--------TGSPLISDE-- 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 238 akgkydithdedlaiihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKavAVKLTDEEIIYLEEL 314
Cdd:cd19121   222 -----------------PVVEIAKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLE--IIDLDDEDMNKLNDI 279
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
29-319 2.18e-15

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 75.60  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPRTQEEIeqgida 103
Cdd:cd19112    15 GLGVWRMEPGEIKELILNAIKIGYRHFDCAADYK---NEKEVGEALAEafktgLVKREDLFITTKLWNSDHGHV------ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 kqhIENCLNgSLKRLDMDYVDLYILH---------------------MW--DYNTPIEDIMAALHDVIRQGKVRYIGISN 160
Cdd:cd19112    86 ---IEACKD-SLKKLQLDYLDLYLVHfpvatkhtgvgttgsalgedgVLdiDVTISLETTWHAMEKLVSAGLVRSIGISN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 161 CYAWQIAKANEIAKAKGYEQFVSIQGHYnlifreeERE-MKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSEDIyak 239
Cdd:cd19112   162 YDIFLTRDCLAYSKIKPAVNQIETHPYF-------QRDsLVKFCQKHGISVTAHTPLGGAAANAEWFGSVSPLDDPV--- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 240 gkydithdedlaiihrVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHR 319
Cdd:cd19112   232 ----------------LKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYR 295
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
29-318 8.60e-15

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 73.30  E-value: 8.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATKfiprtqeeieqgIDAKQH- 106
Cdd:cd19117    18 GLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYG---NEEEVGQGIKDSGvPREEIFITTK------------LWCTWHr 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 107 -IENCLNGSLKRLDMDYVDLYILHmW--------DYNTPIEDIMAALHD--------------VIRQGKVRYIGISNCYA 163
Cdd:cd19117    83 rVEEALDQSLKKLGLDYVDLYLMH-WpvpldpdgNDFLFKKDDGTKDHEpdwdfiktwelmqkLPATGKVKAIGVSNFSI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 164 WQIAKANEIAKAKGYEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSALAS--GRLAKHPgeeskrlsediyakgk 241
Cdd:cd19117   162 KNLEKLLASPSAKIVPAVNQIELHPLL----PQPKLVDFCKSKGIHATAYSPLGStnAPLLKEP---------------- 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 242 ydithdedlAIIhrveELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAvkLTDEEIIYLEELYKPH 318
Cdd:cd19117   222 ---------VII----KIAKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKLFT--LSDEEFKEIDELHKEY 283
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
21-307 1.06e-14

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 73.04  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFG----EAQKGmhswtlpyeESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY------AKREDVIIATKfi 90
Cdd:cd19122    12 VGFGtfanEGAKG---------ETYAAVTKALDVGYRHLDCAWFYL---NEDEVGDAVRDFlkenpsVKREDLFICTK-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  91 prTQEEIEQGIDAKQHIENclngSLKRLDMDYVDLYILHmW-------DYNTPI-----------------EDIMAALHD 146
Cdd:cd19122    78 --VWNHLHEPEDVKWSIDN----SLKNLKLDYIDLFLVH-WpiaaeknDQRSPKlgpdgkyvilkdltenpEPTWRAMEE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 147 VIRQGKVRYIGISNcyaWQIAKANEIAkakgyeQFVSIQGHYNLI----FREEErEMKQYCVAHNIAMTPYSALASGRLA 222
Cdd:cd19122   151 IYESGKAKAIGVSN---WTIPGLKKLL------SFAKVKPHVNQIeihpFLPNE-ELVDYCFSNDILPEAYSPLGSQNQV 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 223 KHPGEeskRLSEDiyakgkydithdedlaiiHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKavAVK 302
Cdd:cd19122   221 PSTGE---RVSEN------------------PTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFK--SIE 277

                  ....*
gi 1797152346 303 LTDEE 307
Cdd:cd19122   278 LSDED 282
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
8-159 1.28e-14

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 73.08  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   8 DSDLMVSKVCLGCMGFGEAQKgmhswTLPYE-ESKKIIKYALDNGINFFDTAIGYqgGTSEAFLGKAIKEYAK---REDV 83
Cdd:cd19164     8 LSLAGLPPLIFGAATFSYQYT-----TDPESiPPVDIVRRALELGIRAFDTSPYY--GPSEIILGRALKALRDefpRDTY 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346  84 IIATKFIPRTQEEIEQgidAKQHIENCLNGSLKRLDMDYVDLYILHMWDYNTPiEDIMAALHDVIR---QGKVRYIGIS 159
Cdd:cd19164    81 FIITKVGRYGPDDFDY---SPEWIRASVERSLRRLHTDYLDLVYLHDVEFVAD-EEVLEALKELFKlkdEGKIRNVGIS 155
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
29-314 3.20e-14

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 71.43  E-value: 3.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYqggTSEAFLGKAI-KEYAKREDVIIATKFiprtqEEIEQGIDAKQhi 107
Cdd:cd19134    15 GLGVGELSDDEAERSVSAALEAGYRLIDTAAAY---GNEAAVGRAIaASGIPRGELFVTTKL-----ATPDQGFTASQ-- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 108 ENClNGSLKRLDMDYVDLYILHmwdYNTPIE----DIMAALHDVIRQGKVRYIGISNCYAWQIakaNEIAKAKGYEQFVS 183
Cdd:cd19134    85 AAC-RASLERLGLDYVDLYLIH---WPAGREgkyvDSWGGLMKLREEGLARSIGVSNFTAEHL---ENLIDLTFFTPAVN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 184 -IQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPgeeskrlsediyakgkydithdedlaiihRVEELAEK 262
Cdd:cd19134   158 qIELHPLL----NQAELRKVNAQHGIVTQAYSPLGVGRLLDNP-----------------------------AVTAIAAA 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 263 KGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19134   205 HGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGL 256
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
40-292 3.26e-14

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 71.72  E-value: 3.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  40 SKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY-----AKREDVIIATKfIPRTQEEIEQgidakqhIENCLNGS 114
Cdd:cd19129    21 TRNAVKAALEAGFRHFDCAERYR---NEAEVGEAMQEVfkagkIRREDLFVTTK-LWNTNHRPER-------VKPAFEAS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 115 LKRLDMDYVDLYILH--------------------MWDYNTPIEDIMAALHDVIRQGKVRYIGISNCYAWQIAKANEIAK 174
Cdd:cd19129    90 LKRLQLDYLDLYLIHtpfafqpgdeqdprdangnvIYDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAAR 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 175 AKgyEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSALAsgrlakHpGEESKRLSEDIyakgkydIThdedlAIIH 254
Cdd:cd19129   170 IK--PAVVQVESHPYL----PEWELLDFCKNHGIVLQAFAPLG------H-GMEPKLLEDPV-------IT-----AIAR 224
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1797152346 255 RVEElaekkgvSMTEISLAWLLTKVTSPIIGATKPHHI 292
Cdd:cd19129   225 RVNK-------TPAQVLLAWAIQRGTALLTTSKTPSRI 255
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
29-321 3.54e-14

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 71.61  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPRTqeeieqgiDA 103
Cdd:cd19125    15 GLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYG---NEKEIGKALKKlfedgVVKREDLFITSKLWCTD--------HA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 KQHIENCLNGSLKRLDMDYVDLYILHmWDYN---------------TPIEDIMAALHDVIRQGKVRYIGISNcyaWQIAK 168
Cdd:cd19125    84 PEDVPPALEKTLKDLQLDYLDLYLIH-WPVRlkkgahmpepeevlpPDIPSTWKAMEKLVDSGKVRAIGVSN---FSVKK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 169 ANEIAKAKGYEQFVSiQGHYNLIFREEerEMKQYCVAHNIAMTPYSALASgrlakhpgeeskrlSEDIYAKGkyDITHDE 248
Cdd:cd19125   160 LEDLLAVARVPPAVN-QVECHPGWQQD--KLHEFCKSKGIHLSAYSPLGS--------------PGTTWVKK--NVLKDP 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1797152346 249 dlaiihRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELyKPHRLV 321
Cdd:cd19125   221 ------IVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSI-EQQRRV 286
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
14-289 4.87e-14

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 71.59  E-value: 4.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  14 SKVCLGCMGFGeaqkGMHSwTLPYEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYaKREDVIIATK----F 89
Cdd:cd19161     1 SELGLGTAGLG----NLYT-AVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREK-PRDEFVLSTKvgrlL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  90 IPRTQEEIEQGID-------------AKQHIENCLNGSLKRLDMDYVDLYILHMWDY------NTPIEDIMA------AL 144
Cdd:cd19161    75 KPAREGSVPDPNGfvdplpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVythgdrKERHHFAQLmsggfkAL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 145 HDVIRQGKVRYIGIS-NcyAWQIakaneIAKAKGYEQF--VSIQGHYNLIFREEEREMKQYCVAHNIAMTPYSALASGRL 221
Cdd:cd19161   155 EELKKAGVIKAFGLGvN--EVQI-----CLEALDEADLdcFLLAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGIL 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1797152346 222 AKHPGEEskrlsediyakGKYDIThDEDLAIIHRVEEL---AEKKGVSMTEISLAWLL--TKVTSPIIGATKP 289
Cdd:cd19161   228 ATGTKSG-----------AKFNYG-DAPAEIISRVMEIekiCDAYNVPLAAAALQFPLrhPAVASVLTGARNP 288
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
27-314 7.17e-14

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 70.52  E-value: 7.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  27 QKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEY------AKREDVIIATKFIPRTQeeieqg 100
Cdd:cd19118     9 AIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQ---NQHEVGQALKELlkeepgVKREDLFITSKLWNNSH------ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 101 idAKQHIENCLNGSLKRLDMDYVDLYILHmW-------------------------DYNTPIEDIMAALHDVIRQGKVRY 155
Cdd:cd19118    80 --RPEYVEPALDDTLKELGLDYLDLYLIH-WpvafkptgdlnpltavptnggevdlDLSVSLVDTWKAMVELKKTGKVKS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 156 IGISNcyaWQIAKANEIAKAKGYEQFVS-IQGHYNLIfreeEREMKQYCVAHNIAMTPYSAL---ASG--RLAKHPGees 229
Cdd:cd19118   157 IGVSN---FSIDHLQAIIEETGVVPAVNqIEAHPLLL----QDELVDYCKSKNIHITAYSPLgnnLAGlpLLVQHPE--- 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 230 krlsediyakgkydithdedlaiihrVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKavAVKLTDEEII 309
Cdd:cd19118   227 --------------------------VKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFN 278

                  ....*
gi 1797152346 310 YLEEL 314
Cdd:cd19118   279 AVTAL 283
PRK10376 PRK10376
putative oxidoreductase; Provisional
21-312 1.43e-13

putative oxidoreductase; Provisional


Pssm-ID: 236676 [Multi-domain]  Cd Length: 290  Bit Score: 70.00  E-value: 1.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  21 MGFGEAQ-KGMHSWTLP--YEESKKIIKYALDNGINFFDTAIGYQGGTSEAFLGKAIKEYakREDVIIATK--------- 88
Cdd:PRK10376   20 LGYGAMQlAGPGVFGPPkdRDAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIREALHPY--PDDLTIVTKvgarrgedg 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  89 -FIP-RTQEEIEQGIdakqHiENCLNGSLKRLDMdyVDLYIlhMWDYNTP----IEDIMAALHDVIRQGKVRYIGISNCY 162
Cdd:PRK10376   98 sWLPaFSPAELRRAV----H-DNLRNLGLDVLDV--VNLRL--MGDGHGPaegsIEEPLTVLAELQRQGLVRHIGLSNVT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 163 AWQIAKANEIAKakgyeqFVSIQGHYNLIFREEEREMKQYcVAHNIAMTPY------SALASGRLAkhpgeeskrlsedi 236
Cdd:PRK10376  169 PTQVAEARKIAE------IVCVQNHYNLAHRADDALIDAL-ARDGIAYVPFfplggfTPLQSSTLS-------------- 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 237 yakgkydithdedlaiihrveELAEKKGVSMTEISLAWLLTKvtSP----IIGATKPHHIDGAVKAVAVKLTDEEIIYLE 312
Cdd:PRK10376  228 ---------------------DVAASLGATPMQVALAWLLQR--SPnillIPGTSSVAHLRENLAAAELVLSEEVLAELD 284
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
29-160 3.72e-13

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 68.59  E-value: 3.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KREDVIIATK-FIPrtqeeiEQGIDAKQH 106
Cdd:cd19127    13 GLGVFQTPPEETADAVATALADGYRLIDTAAAYG---NEREVGEGIRRSGvDRSDIFVTTKlWIS------DYGYDKALR 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1797152346 107 ienCLNGSLKRLDMDYVDLYILHmWDYNTPIEDIMAALHDVIR---QGKVRYIGISN 160
Cdd:cd19127    84 ---GFDASLRRLGLDYVDLYLLH-WPVPNDFDRTIQAYKALEKllaEGRVRAIGVSN 136
AKR_unchar cd19098
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
47-317 2.38e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381324 [Multi-domain]  Cd Length: 318  Bit Score: 66.60  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  47 ALDNGINFFDTAIGYqgGTSEAFLGKAIKEYA-KREDVIIATKFIPRTQEEIEqgIDAKQHIENclNGSLKRLDM----- 120
Cdd:cd19098    44 AWAAGVRYFDAARSY--GRAEEFLGSWLRSRNiAPDAVFVGSKWGYTYTADWQ--VDAAVHEVK--DHSLARLLKqweet 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 121 -----DYVDLYILHMWDYNTPI---EDIMAALHDVIRQGkvRYIGISNCYAWQ---IAKANEIAkAKGYEQFVSIQGHYN 189
Cdd:cd19098   118 rsllgKHLDLYQIHSATLESGVledADVLAALAELKAEG--VKIGLSLSGPQQaetLRRALEIE-IDGARLFDSVQATWN 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 190 LIfreEEREMKQYCVAHNIAMTPY--SALASGRLAKHPgeeskrlsediyakgkydiTHDEDLAIIHRVEELAEKKGVSM 267
Cdd:cd19098   195 LL---EQSAGEALEEAHEAGMGVIvkEALANGRLTDRN-------------------PSPELAPLMAVLKAVADRLGVTP 252
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 268 TEISLAWLLTKVTSPII--GATKPHHIDGAVKAVAVKLTDEEIIYLEELYKP 317
Cdd:cd19098   253 DALALAAVLAQPFVDVVlsGAATPEQLRSNLRALDVSLDLELLAALADLAEP 304
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
4-276 3.43e-12

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 65.86  E-value: 3.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346   4 VKLGDSDLMvskvclgcmgfgeAQKGMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKEYA-KRED 82
Cdd:PRK11565    7 IKLQDGNVM-------------PQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEASvAREE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  83 VIIATKFIPrtqeeieqgiDAKQHIENCLNGSLKRLDMDYVDLYILHmWDYnTPIEDIMAALHDVI---RQGKVRYIGIS 159
Cdd:PRK11565   71 LFITTKLWN----------DDHKRPREALEESLKKLQLDYVDLYLMH-WPV-PAIDHYVEAWKGMIelqKEGLIKSIGVC 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 160 NcyaWQIAKANEIAKAKGYEQFVS-IQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGrlakhpgeeskrlsediyA 238
Cdd:PRK11565  139 N---FQIHHLQRLIDETGVTPVINqIELHPLM----QQRQLHAWNATHKIQTESWSPLAQG------------------G 193
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1797152346 239 KGKYdithdeDLAIIHRveeLAEKKGVSMTEISLAWLL 276
Cdd:PRK11565  194 KGVF------DQKVIRD---LADKYGKTPAQIVIRWHL 222
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
29-308 5.53e-11

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 62.44  E-value: 5.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPRTQEeieqgida 103
Cdd:cd19107     8 GLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQ---NENEVGEAIQEkikeqVVKREDLFIVSKLWCTFHE-------- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 KQHIENCLNGSLKRLDMDYVDLYILHmW--------DY------------NTPIEDIMAALHDVIRQGKVRYIGISNCYA 163
Cdd:cd19107    77 KGLVKGACQKTLSDLKLDYLDLYLIH-WptgfkpgkELfpldesgnvipsDTTFLDTWEAMEELVDEGLVKAIGVSNFNH 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 164 WQIAKaneIAKAKG--YEQFVS-IQGHYNLifreEEREMKQYCVAHNIAMTPYSALAS-GRLAKHPGEESkrLSEDiyak 239
Cdd:cd19107   156 LQIER---ILNKPGlkYKPAVNqIECHPYL----TQEKLIQYCQSKGIVVTAYSPLGSpDRPWAKPEDPS--LLED---- 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1797152346 240 gkydithdedlaiiHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19107   223 --------------PKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDM 277
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
22-216 5.82e-11

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 62.44  E-value: 5.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  22 GFGeaqkgmhSWTLPYEESKKIIKYALDNGINFFDTAIGYqGGTSEAFLG--KAIKE-YAKREDVIIATKfiprtqeeIE 98
Cdd:cd19115    17 GFG-------LWKVNNDTCADQVYNAIKAGYRLFDGACDY-GNEVEAGQGvaRAIKEgIVKREDLFIVSK--------LW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  99 QGIDAKQHIENCLNGSLKRLDMDYVDLYILHM----------------WDY--------NTPIEDIMAALHDVIRQGKVR 154
Cdd:cd19115    81 NTFHDGERVEPICRKQLADWGIDYFDLFLIHFpialkyvdpavryppgWFYdgkkvefsNAPIQETWTAMEKLVDKGLAR 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1797152346 155 YIGISNCYAWQIAKANEIAKAKgyEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSAL 216
Cdd:cd19115   161 SIGVSNFSAQLLMDLLRYARIR--PATLQIEHHPYL----TQPRLVKYAQKEGIAVTAYSSF 216
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
29-215 1.14e-10

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 61.69  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYqGGTSEAFLG--KAIKE-YAKREDVIIATKfiprtqeeIEQGIDAKQ 105
Cdd:cd19113    15 GFGCWKLDNATAADQIYQAIKAGYRLFDGAEDY-GNEKEVGEGvnRAIDEgLVKREELFLTSK--------LWNNFHDPK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 106 HIENCLNGSLKRLDMDYVDLYILHM------------------------WDY-NTPIEDIMAALHDVIRQGKVRYIGISN 160
Cdd:cd19113    86 NVETALNKTLSDLKLDYVDLFLIHFpiafkfvpieekyppgfycgdgdnFVYeDVPILDTWKALEKLVDAGKIKSIGVSN 165
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 161 CYAWQIAKANEIAKAKgyEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSA 215
Cdd:cd19113   166 FPGALILDLLRGATIK--PAVLQIEHHPYL----QQPKLIEYAQKAGITITAYSS 214
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
27-308 1.32e-10

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 60.69  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  27 QKGMHSWTLPYEESKKIIKYALDNGINFFDTA--IGYQGGTSEAFLGKAIKeyakREDVIIATKFIPRTQ--EEIEQGID 102
Cdd:cd19130    12 QLGYGVFKVPPADTQRAVATALEVGYRHIDTAaiYGNEEGVGAAIAASGIP----RDELFVTTKLWNDRHdgDEPAAAFA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 103 AkqhienclngSLKRLDMDYVDLYILHmwdYNTPIEDIM----AALHDVIRQGKVRYIGISNcyaWQIAKANEIAKAKGY 178
Cdd:cd19130    88 E----------SLAKLGLDQVDLYLVH---WPTPAAGNYvhtwEAMIELRAAGRTRSIGVSN---FLPPHLERIVAATGV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 179 EQFVS-IQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPGeeskrlsediyakgkydithdedlaiihrVE 257
Cdd:cd19130   152 VPAVNqIELHPAY----QQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPP-----------------------------VG 198
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1797152346 258 ELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEI 308
Cdd:cd19130   199 AIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEI 249
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
29-320 1.64e-10

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 61.13  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYQGgTSEAFLG--KAIKEYA-KREDVIIATKFIPRTQEeieqgidaKQ 105
Cdd:cd19110     8 GLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHN-ESEVGAGirEKIKEGVvRREDLFIVSKLWCTCHK--------KS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 106 HIENCLNGSLKRLDMDYVDLYILHmWDY--------------------NTPIEDIMAALHDVIRQGKVRYIGISNCYAWQ 165
Cdd:cd19110    79 LVKTACTRSLKALKLNYLDLYLIH-WPMgfkpgepdlpldrsgmvipsDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQ 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 166 IAKANEIAKAKGYEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSALASgrlakhpgeeskrlsediyAKGKYDIT 245
Cdd:cd19110   158 LERLLNKPGLRVKPVTNQIECHPYL----TQKKLISFCQSRNVSVTAYRPLGG-------------------SCEGVDLI 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1797152346 246 HDedlAIIHRVeelAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRL 320
Cdd:cd19110   215 DD---PVIQRI---AKKHGKSPAQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRL 283
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
34-321 8.32e-09

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 55.96  E-value: 8.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  34 TLPYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATKFIPRTQEeieqgidaKQHIE 108
Cdd:cd19109    17 TTPKGACAEAVKVAIDTGYRHIDGAYIYQ---NEHEVGQAIREkiaegKVKREDIFYCGKLWNTCHP--------PELVR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 109 NCLNGSLKRLDMDYVDLYILHMWDYNTPIEDIMAALHDvirqGKVRYIGISNCYAWQ---IAKANEIAKAKGYEQFVSIQ 185
Cdd:cd19109    86 PTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDEN----GKWLYHKTNLCATWEaleACKDAGLVKSIGVSNFNRRQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 186 ghYNLIFRE------------------EEREMKQYCVAHNIAMTPYSALASGRLAKHPGEESKRLSEDiyakgkydithd 247
Cdd:cd19109   162 --LELILNKpglkhkpvsnqvechpyfTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLED------------ 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1797152346 248 edlaiiHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEELYKPHRLV 321
Cdd:cd19109   228 ------PLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYV 295
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
29-314 1.16e-08

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 55.26  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  29 GMHSWTLPYEESKKIIKYALDNGINFFDTAIGYqggTSEAFLGKAIKE-----YAKREDVIIATKfiprtqeeIEQGIDA 103
Cdd:cd19114     8 GFGTAKIKANETEEVIYNAIKVGYRLIDGALLY---GNEAEVGRGIRKaiqegLVKREDLFIVTK--------LWNNFHG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 104 KQHIENCLNGSLKRLDMDYVDLYILH----------------MWDY---------NTPIEDIMAALHDVIRQGKVRYIGI 158
Cdd:cd19114    77 KDHVREAFDRQLKDYGLDYIDLYLIHfpipaayvdpaenypfLWKDkelkkfpleQSPMQECWREMEKLVDAGLVRNIGI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346 159 SNCYAWQIAKANEIAKAKgyEQFVSIQGHYNLifreEEREMKQYCVAHNIAMTPYSALASGRLAKHPgEESKRLSediya 238
Cdd:cd19114   157 ANFNVQLILDLLTYAKIK--PAVLQIEHHPYL----QQKRLIDWAKKQGIQITAYSSFGNAVYTKVT-KHLKHFT----- 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1797152346 239 kgkydithdeDLAIIHRVEELAEKKGVSMTEISLAWLLTKVTSPIIGATKPHHIDGAVKAVAVKLTDEEIIYLEEL 314
Cdd:cd19114   225 ----------NLLEHPVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYEL 290
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
36-129 1.43e-08

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 55.31  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1797152346  36 PYEESKKIIKYALDNGINFFDTAIGYQggtSEAFLGKAIKE-----YAKREDVIIATK-----FIPrtqeeieqgidakQ 105
Cdd:cd19108    25 PKSKALEATKLAIDAGFRHIDSAYLYQ---NEEEVGQAIRSkiadgTVKREDIFYTSKlwctfHRP-------------E 88
                          90       100
                  ....*....|....*....|....
gi 1797152346 106 HIENCLNGSLKRLDMDYVDLYILH 129
Cdd:cd19108    89 LVRPALEKSLKKLQLDYVDLYLIH 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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