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Conserved domains on  [gi|1788882369|ref|XP_031807008|]
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kelch repeat and BTB domain-containing protein 11 [Sarcophilus harrisii]

Protein Classification

kelch repeat and BTB domain-containing protein 11( domain architecture ID 13033288)

kelch repeat and BTB domain-containing protein 11 (KBTBD11) is a BTB-Kelch family protein

Gene Symbol:  KBTBD11
Gene Ontology:  GO:0005515
PubMed:  13678422|15544948|10603472|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-319 3.05e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 192.70  E-value: 3.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 296
Cdd:cd18275     3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                          90       100
                  ....*....|....*....|...
gi 1788882369 297 CALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18275    82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 310-386 9.33e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


:

Pssm-ID: 350559  Cd Length: 77  Bit Score: 143.68  E-value: 9.33e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788882369 310 LTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSVYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 386
Cdd:cd18484     1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
445-682 3.85e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 3.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 445 EWKVLTQLPEG-ANAkgcAMCVLYNYLFLAGGILQGGPegrarlSDKVFCYNPVTDTWTTVRSLN-QPRSQLKLLALDGY 522
Cdd:COG3055     2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 523 LYAVGG--------ECLFSVERYDPRADRWSTVAPLPKGafAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 590
Cdd:COG3055    73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 591 EC-PCSSSRKRSADMVALKGFIYrfdLCGARGE-------------PQAVAGTSTASGSGGV-----------NVFRYHC 645
Cdd:COG3055   151 QLaPLPTPRDHLAAAVLPDGKIL---VIGGRNGsgfsntwttlaplPTARAGHAAAVLGGKIlvfggesgfsdEVEAYDP 227

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1788882369 646 LAKRWSQcASNLrpPGEASGLQPFrctALDGTIYCVN 682
Cdd:COG3055   228 ATNTWTA-LGEL--PTPRHGHAAV---LTDGKVYVIG 258
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-319 3.05e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 192.70  E-value: 3.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 296
Cdd:cd18275     3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                          90       100
                  ....*....|....*....|...
gi 1788882369 297 CALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18275    82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 310-386 9.33e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 143.68  E-value: 9.33e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788882369 310 LTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSVYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 386
Cdd:cd18484     1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
445-682 3.85e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 3.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 445 EWKVLTQLPEG-ANAkgcAMCVLYNYLFLAGGILQGGPegrarlSDKVFCYNPVTDTWTTVRSLN-QPRSQLKLLALDGY 522
Cdd:COG3055     2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 523 LYAVGG--------ECLFSVERYDPRADRWSTVAPLPKGafAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 590
Cdd:COG3055    73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 591 EC-PCSSSRKRSADMVALKGFIYrfdLCGARGE-------------PQAVAGTSTASGSGGV-----------NVFRYHC 645
Cdd:COG3055   151 QLaPLPTPRDHLAAAVLPDGKIL---VIGGRNGsgfsntwttlaplPTARAGHAAAVLGGKIlvfggesgfsdEVEAYDP 227

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1788882369 646 LAKRWSQcASNLrpPGEASGLQPFrctALDGTIYCVN 682
Cdd:COG3055   228 ATNTWTA-LGEL--PTPRHGHAAV---LTDGKVYVIG 258
PHA03098 PHA03098
kelch-like protein; Provisional
 221-594 1.44e-19

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 92.91  E-value: 1.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 221 LVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVK---GVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 297
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlNIDYDSFNEVIKYIYTGKI-NITSNNVKDILSIANYLIIDF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 298 ALQCATDAMRAQLTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSvYGRLTGSERDLILQRRM--------- 368
Cdd:PHA03098   93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPD-FIYLSKNELIKILSDDKlnvssedvv 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 369 ----------EAGRSCLLVAEINDV-------------FERVGSRPQ---------------------SRESSRPQSPSA 404
Cdd:PHA03098  172 leiiikwltsKKNNKYKDICLILKVlritflseegikkLKRWKLRIKkkkivfnkrcikiiyskkynlNKILPRSSTFGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 405 SVLSPGEQPPTPPPALAPGSSEEE-------------------------GG-----HSDSVIYYYQEADKEWKVLTQLpe 454
Cdd:PHA03098  252 IIYIHITMSIFTYNYITNYSPLSEintiidihyvycfgsvvlnnviyfiGGmnknnLSVNSVVSYDTKTKSWNKVPEL-- 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 455 GANAKGCAMCVLYNYLFLAGGILQGGPegrarLSDkVFCYNPVTDTWTTVRSLNQPRSQLKLLALDGYLYAVGG-----E 529
Cdd:PHA03098  330 IYPRKNPGVTVFNNRIYVIGGIYNSIS-----LNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndE 403

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1788882369 530 CLFSVERYDPRADRWSTVAPLP---KGAFAVAHeattcNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 594
Cdd:PHA03098  404 LLKTVECFSLNTNKWSKGSPLPishYGGCAIYH-----DGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 216-310 7.11e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 79.61  E-value: 7.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgeVKQDNVAEVIA 288
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 1788882369 289 GARFLQMPCALQCATDAMRAQL 310
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 220-310 3.24e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 3.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369  220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKL-DLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1788882369  293 LQMPCALQCATDAMRAQL 310
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 428-552 4.68e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 56.31  E-value: 4.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 428 EGGHSDSVIYYYQEADKEWKVLTQLPEgANAKGCAMcVLYNYLFLAGGILQGGPEGRARLsdkVFCYNPVTDTWTTVRSL 507
Cdd:PHA03098  400 KNDELLKTVECFSLNTNKWSKGSPLPI-SHYGGCAI-YHDGKIYVIGGISYIDNIKVYNI---VESYNPVTNKWTELSSL 474

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1788882369 508 NQPRSQLKLLALDGYLYAVGGECLFS----VERYDPRADRWSTVAPLPK 552
Cdd:PHA03098  475 NFPRINASLCIFNNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 510-551 6.41e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 6.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1788882369 510 PRSQLKLLALDGYLYAVGG----ECLFSVERYDPRADRWSTVAPLP 551
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
523-566 8.80e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 8.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1788882369  523 LYAVGG----ECLFSVERYDPRADRWSTVAPLPKGAFAVAheATTCNG 566
Cdd:smart00612   2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHG--VAVING 47
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-319 3.05e-58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 192.70  E-value: 3.05e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQMP 296
Cdd:cd18275     3 GEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQMP 81

                          90       100
                  ....*....|....*....|...
gi 1788882369 297 CALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18275    82 CAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 310-386 9.33e-41

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 143.68  E-value: 9.33e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788882369 310 LTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSVYGRLTGSERDLILQRRMEAGRSCLLVAEINDVFER 386
Cdd:cd18484     1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
445-682 3.85e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 114.48  E-value: 3.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 445 EWKVLTQLPEG-ANAkgcAMCVLYNYLFLAGGILQGGPegrarlSDKVFCYNPVTDTWTTVRSLN-QPRSQLKLLALDGY 522
Cdd:COG3055     2 TWSSLPDLPTPrSEA---AAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 523 LYAVGG--------ECLFSVERYDPRADRWSTVAPLPKGafAVAHEATTCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 590
Cdd:COG3055    73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 591 EC-PCSSSRKRSADMVALKGFIYrfdLCGARGE-------------PQAVAGTSTASGSGGV-----------NVFRYHC 645
Cdd:COG3055   151 QLaPLPTPRDHLAAAVLPDGKIL---VIGGRNGsgfsntwttlaplPTARAGHAAAVLGGKIlvfggesgfsdEVEAYDP 227

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1788882369 646 LAKRWSQcASNLrpPGEASGLQPFrctALDGTIYCVN 682
Cdd:COG3055   228 ATNTWTA-LGEL--PTPRHGHAAV---LTDGKVYVIG 258
PHA03098 PHA03098
kelch-like protein; Provisional
 221-594 1.44e-19

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 92.91  E-value: 1.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 221 LVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVK---GVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 297
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEinlNIDYDSFNEVIKYIYTGKI-NITSNNVKDILSIANYLIIDF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 298 ALQCATDAMRAQLTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSvYGRLTGSERDLILQRRM--------- 368
Cdd:PHA03098   93 LINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPD-FIYLSKNELIKILSDDKlnvssedvv 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 369 ----------EAGRSCLLVAEINDV-------------FERVGSRPQ---------------------SRESSRPQSPSA 404
Cdd:PHA03098  172 leiiikwltsKKNNKYKDICLILKVlritflseegikkLKRWKLRIKkkkivfnkrcikiiyskkynlNKILPRSSTFGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 405 SVLSPGEQPPTPPPALAPGSSEEE-------------------------GG-----HSDSVIYYYQEADKEWKVLTQLpe 454
Cdd:PHA03098  252 IIYIHITMSIFTYNYITNYSPLSEintiidihyvycfgsvvlnnviyfiGGmnknnLSVNSVVSYDTKTKSWNKVPEL-- 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 455 GANAKGCAMCVLYNYLFLAGGILQGGPegrarLSDkVFCYNPVTDTWTTVRSLNQPRSQLKLLALDGYLYAVGG-----E 529
Cdd:PHA03098  330 IYPRKNPGVTVFNNRIYVIGGIYNSIS-----LNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndE 403

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1788882369 530 CLFSVERYDPRADRWSTVAPLP---KGAFAVAHeattcNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 594
Cdd:PHA03098  404 LLKTVECFSLNTNKWSKGSPLPishYGGCAIYH-----DGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-293 1.79e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 83.37  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMfssgmkeSSSSEIELDDVSPEAFEALLDYIYTGEL-ELSEENVEELLAAADK 81


                  .
gi 1788882369 293 L 293
Cdd:cd18186    82 L 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 216-310 7.11e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 79.61  E-value: 7.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgeVKQDNVAEVIA 288
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGKL--ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 1788882369 289 GARFLQMPCALQCATDAMRAQL 310
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 9.03e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 79.33  E-value: 9.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAmftndvrEATEEEIKLKDVDPDALWTLVQYCYTGRL-ELKEDNVESLLATACL 81

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18234    82 LQLSEVVEACCGFLMKQLHPSNC 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 220-310 3.24e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 77.35  E-value: 3.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369  220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKL-DLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1788882369  293 LQMPCALQCATDAMRAQL 310
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.64e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 76.28  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 292
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSDYFRAmftggmrESSQDEIELKGVSAKGLKHILDFAYTSELT-LDLDCIQDVLGAAVH 98

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18255    99 LQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 9.85e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 74.22  E-value: 9.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKS----DYFRARSSREILR---VKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18306    20 DVILQVGGHEIPAHRAVLACASpylfELFSSDSDGESILtvkLDGLDPDAVEVLVNYAYTSRL-EVPADLVKSVYSAAKK 98

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18306    99 LKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.04e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 73.98  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18256    22 DVQLQVGMELFSVHRLVLAASSPYFAAlfaggmsESSKDVVQIHGVEPDIFHILLDFIYTGVV-EVTVSNVQELLVAADM 100

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18256   101 LQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.48e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 73.48  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18238    17 DVTLKVGEKSIHCHRLVLACVSPYFRAmftsemaESKQDSITIKDIDEEAVELLVDFAYTGKL-TLTVDNVQSLLYAASL 95

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18238    96 LQVEEVAKACCEFMKDHLHPSNC 118
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
436-574 6.87e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.58  E-value: 6.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 436 IYYYQEADKEWKVLTQLPEGANAKGCAmcVLYNYLFLAGGILQGGPEGrarlsdKVFCYNPVTDTWTTVRSLNQPRSQL- 514
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATAL--LLDGKIYVVGGWDDGGNVA------WVEVYDPATGTWTQLAPLPTPRDHLa 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 515 -------KLL------------------------------ALDGYLYAVGGECLFS--VERYDPRADRWSTVAPLPKGAF 555
Cdd:COG3055   164 aavlpdgKILviggrngsgfsntwttlaplptaraghaaaVLGGKILVFGGESGFSdeVEAYDPATNTWTALGELPTPRH 243

                         170
                  ....*....|....*....
gi 1788882369 556 AVAheATTCNGEIYVSGGS 574
Cdd:COG3055   244 GHA--AVLTDGKVYVIGGE 260
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 1.36e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 67.89  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSRE--------ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 291
Cdd:cd18293    17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEpppagqkvVLELQGLKAHTLLKLVDFLYTSEL-EVSSEEAQDVLAAAR 95


                  ....*
gi 1788882369 292 FLQMP 296
Cdd:cd18293    96 RLQIS 100
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.98e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 67.49  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA------RSSR-EILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 292
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAmfagelRESRaDRVVLHGVSAEILGLLLDFSYTGRVT-VTQDNVEALLRAADL 101

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18250   102 FQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-304 3.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 67.15  E-value: 3.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR---ARSSREI----LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18251    25 DVVLVVEGKPIEAHRILLAASCDYFRgmfAGGLREMqqteVLIHGVSYNAMCKILDFIYTSEL-ELSLDNVQETLTAACQ 103

                          90
                  ....*....|..
gi 1788882369 293 LQMPCALQCATD 304
Cdd:cd18251   104 LQIPEVIGFCCD 115
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.63e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 64.77  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAmftsemsEKGKSEVELQGLTASTMEILLDFVYTETV-HVTVENVQELLPAACL 101

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18242   102 LQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-310 3.04e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 64.10  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIA 288
Cdd:cd18257    16 HELCDVVLRVGDVKIHAHKVVLASCSPYFKAmftgnlsEKENSEVEFQCIDETALQAIVEYAYTGTVF-ISQATVESLLP 94

                          90       100
                  ....*....|....*....|..
gi 1788882369 289 GARFLQMPCALQCATDAMRAQL 310
Cdd:cd18257    95 AANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 3.54e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 63.99  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18235    23 DVILVADGVEIPAHRVVLASCSPYFHAmftgdlsESRANRVTLQDVDGKALLLLIDYVYTAEI-QVTEENVQVLLPAANL 101

                          90
                  ....*....|....*...
gi 1788882369 293 LQMPCALQCATDAMRAQL 310
Cdd:cd18235   102 LQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 4.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 63.66  E-value: 4.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR---------ARSSReiLRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAASHFFHlmftsnmteSKSSE--VELKDAEPDIIELLVEFAYTARI-SVNSNNVQSLLDAA 99

                          90       100
                  ....*....|....*....|....*
gi 1788882369 291 RFLQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18237   100 NQYQIEPVKKMCVDFLKEQLDASNC 124
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 222-315 4.96e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 63.53  E-value: 4.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 222 VIEVAG-RRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18336    22 VLLIAGnLKIPAHRLVLSAVSDYFAAmftndvrEAKQEEIKMEGVDPDALKALVHYAYTGVL-ELKEDTIESLLAAACLL 100

                          90       100
                  ....*....|....*....|..
gi 1788882369 294 QMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18336   101 QLSQVIDVCCNFLMKQLHPSNC 122
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 220-294 5.59e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 62.18  E-value: 5.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-----RSSRE-ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAAllketPPDEHpVIILPDVPYSELKALLDFIYTGEV-NVSQEQLESLLKLAELL 81


                  .
gi 1788882369 294 Q 294
Cdd:cd18315    82 Q 82
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 6.61e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 62.68  E-value: 6.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA--------RSSREILrVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 291
Cdd:cd18247    21 DVTLKVGDQKFSAHRIVLAATIPYFHAmfthdmveSKQDEIT-MQGIEPSALEALINFAYSGRI-AIDTSNVQSLLVGAS 98


                  ....*
gi 1788882369 292 FLQMP 296
Cdd:cd18247    99 FLQLQ 103
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-315 1.02e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 62.34  E-value: 1.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIA 288
Cdd:cd18240    15 GKLCDVVIRVNGVEFPAHRNILCACSPYFRAlftngwnETEKKVYKIPGVSPEMMELIIEYAYTRTV-PITAENVEELLP 93

                          90       100
                  ....*....|....*....|....*...
gi 1788882369 289 GA-RFLQMPCALQCAtDAMRAQLTLSNC 315
Cdd:cd18240    94 AAdQFNIMGIVKACC-DFLEDQLCPENC 120
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 2.82e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 61.34  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18268    25 DVILCTGDKEIPCHRNVLASSSPYFRAmfcnnfrESSQAKVDLKGIDSDVLDQIVDYVYTGEI-LITRDNVLPLMEAASM 103

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18268   104 LQYPKLFEACSLYLQDQLTPENC 126
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 216-290 5.25e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 60.35  E-value: 5.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQDNVAEVIA 288
Cdd:cd18286    15 GEDSDITIKVDGKTFKAHRCILCARSSYFAAmlsgswaESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVNLGELLS 94


                  ..
gi 1788882369 289 GA 290
Cdd:cd18286    95 LA 96
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 215-290 7.85e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.94  E-value: 7.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 215 LGEE-PDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHM--GEVKQDNVA 284
Cdd:cd18287    18 LNEEySDVTFVVEEKRFPAHRVILAARSEYFRAllyggmrESQQSEIELKDTNAEAFKALLKYIYTGRLtlTDLKEDVLL 97


                  ....*.
gi 1788882369 285 EVIAGA 290
Cdd:cd18287    98 DVLGLA 103
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-319 4.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 58.68  E-value: 4.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVA--------GRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVA 284
Cdd:cd18273    28 DVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSmftgglyESKQETVTIHDVDSESMALIIDYCYTGRV-TLSEANVQ 106

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1788882369 285 EVIAGARFLQMPCALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18273   107 RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 203-318 5.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 57.69  E-value: 5.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 203 CSISQSDPTGGALGEEPDLVIEV-AGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGH 274
Cdd:cd18274     7 CSILQQLKAMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSmftsgltESTQKEVRIVGVEAESMHLVLDYAYTSR 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1788882369 275 MgEVKQDNVAEVIAGARFLQMPCAL-QCAtDAMRAQLTLSNCYQV 318
Cdd:cd18274    87 V-TLTEANVQALFTAASIFQIPSLQdQCA-QFMISRLDPQNSIGV 129
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-318 6.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 57.54  E-value: 6.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR---SSREilRVKG------VSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18271    26 DFNIIVKDETIPCHRCVLAACSDFFRAMfevNMKE--RDDGsvtisnLSPKAVKAFLDYAYTGKA-EITDDNVEMFFQMS 102

                          90       100
                  ....*....|....*....|....*...
gi 1788882369 291 RFLQMPCALQCATDAMRAQLTLSNCYQV 318
Cdd:cd18271   103 SFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-296 7.57e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 56.86  E-value: 7.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA--------RSSREIlRVKGVSYAALRLLVDYLYTGHMGEVKQDNVAEVIAGAR 291
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAmfggnfreSSAKEV-ELPGVSKETFLALLEYLYTDQAPILEDGDCVGLIVLAN 89


                  ....*
gi 1788882369 292 FLQMP 296
Cdd:cd18300    90 RLCLP 94
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 56.98  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18335    21 DVILIAGNRKIPAHRLVLSAVSDYFAAmftsdvcEAKQEEIKMEGIDPNALWDLVQFAYTGCL-ELKEDTIENLLAAACL 99

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18335   100 LQLSQVVEVCCHFLMKLLHPSNC 122
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 57.11  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA------RSSRE-ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRAlfkdytQESKArVIHLPVVSAAGLQRVLDFIYTSWL-SLSLDTLEDTLEAASY 108

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18264   109 LQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 1.89e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 56.22  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18337    25 DVVLVAGDRRIPAHRLVLSSVSDYFAAmftndvrEAKQEEIKMEGVEPNALWALVQYAYTGRL-ELKEDNIECLLSTACL 103

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18337   104 LQLSQVVEACCKFLMKQLHPSNC 126
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 2.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 55.92  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18249    25 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaesrqteVTIRDIDERAMELLIDFAYTSQI-TVEEGNVQTLLPAACL 103

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18249   104 LQLAEIQEVCCEFLKRQLDPSNC 126
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 216-287 2.53e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 55.72  E-value: 2.53e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYF------RARSSREI-LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVI 287
Cdd:cd18295    17 GSYSDVTFNVHGESFPAHRCILSARSPYFaemfetKWKDKREInLKHPLVNPDAFRALLQYLYTGRL-EIHVDDVEDCK 94
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 2.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 55.61  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA------RSSREIL-RVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18253    20 DVIICVEGREFPCHRAILSACSSYFRAmfcndhRESREMLvEINGILAEAMDCFLQYVYTGKV-KITTENVQYLFETSSL 98

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18253    99 FQISPLRDACAKFLEEQLDPCNC 121
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-296 3.20e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 54.91  E-value: 3.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGR-RIQAHKSVLAAKSDYFRA--RSSREILRVKGVSYAALRLLVDYLYTGHMGEvKQDNVAEVIAGARFLQMP 296
Cdd:cd18299    14 DVVFILQGGvRIFAHRIVLAAASSVFADlfLMMTVVTLDSDITPEAFRRVLEFLYTGVLDE-NEDDLKELKDAAELLELF 92
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-304 4.05e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 54.94  E-value: 4.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR-------ARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSAEALTALLDFAYTATL-TVSTSNVGDILSAARL 105

                          90
                  ....*....|..
gi 1788882369 293 LQMPCALQCATD 304
Cdd:cd18326   106 LEIPAVSHVCAD 117
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 6.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 54.78  E-value: 6.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18265    25 DVVLLVDGKDFPCHRATLSANSAYFRAmfgghlkESRQAVVEIQKVSAAAMEVLLDYMYGGGL-RIQEDNVESVLEASDL 103

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18265   104 LQVSKLREACVRFLEGQLHPCNC 126
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-318 7.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 54.46  E-value: 7.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18340    29 DCVLKIKEKEFPCHRLVLAACSPYFRAMflsdleeSKKREIVLEDVDPDVMGKILHYIYTSEI-EITEQNVQDIFAAANM 107

                          90       100
                  ....*....|....*....|....*.
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNCYQV 318
Cdd:cd18340   108 FQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 53.39  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA----------RSSREILRVkgVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAG 289
Cdd:cd18330    20 DCSIIVEGRIFKAHRNILFANSGYFRAllihyiqdsgRHSTASLDI--VTSEAFSIILDFLYSGKL-DLCSENVIEVMSA 96


                  ....*.
gi 1788882369 290 ARFLQM 295
Cdd:cd18330    97 ASYLQM 102
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-313 1.72e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.53  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF--------RARSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGAR 291
Cdd:cd18230    23 DVCIIVEGKIFKAHKNVLLGSSRYFktlycqvqKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA-LTSKNVIEVMSAAS 101

                          90       100
                  ....*....|....*....|..
gi 1788882369 292 FLQMPCALQCATDAMRAQLTLS 313
Cdd:cd18230   102 YLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 2.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 52.80  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18339    23 DVTIVAEDVEIEAHRVVLAACSPYFCAmftgdmsESKAKKIEIKDVDGQTLSKLIDYIYTAEI-EVTEENVQVLLPAASL 101

                          90
                  ....*....|....*...
gi 1788882369 293 LQMPCALQCATDAMRAQL 310
Cdd:cd18339   102 LQLMDVRQNCCDFLQSQL 119
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-300 2.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 52.49  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSR----EILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 295
Cdd:cd18226    24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKnpntDAVTLDHVSYSVFQHLLEFLYTSEF-FVYENEIPLVLEAAKFLDI 102


                  ....*
gi 1788882369 296 PCALQ 300
Cdd:cd18226   103 IDAVK 107
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-317 2.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 53.12  E-value: 2.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPCAL 299
Cdd:cd18243    34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIGLRLVLEYLYTANV-TLSLDTVEEVLSVSKILHIPQVT 112

                          90
                  ....*....|....*...
gi 1788882369 300 QCATDAMRAQLTLSNCYQ 317
Cdd:cd18243   113 KLCVQFLNDQISVQNYKQ 130
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-300 3.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 51.93  E-value: 3.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF----RARSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQDNVAEVIAGARFLQM 295
Cdd:cd18221    20 DITLIVDGHQFKAHKAVLAACSQFFykffQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEANDVWKAAEYLQM 99


                  ....*
gi 1788882369 296 PCALQ 300
Cdd:cd18221   100 QEAIK 104
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-314 4.67e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 51.89  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGE--VKQDNVAEVIAGA 290
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSmlssgstEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESldVAQDDALELLRAA 93

                          90       100
                  ....*....|....*....|....*
gi 1788882369 291 RFLQMPcALQCATDAMRAQ-LTLSN 314
Cdd:cd18297    94 SFFQLD-GLKRHCEILLSQqIDLDN 117
PHA03098 PHA03098
kelch-like protein; Provisional
 428-552 4.68e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 56.31  E-value: 4.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 428 EGGHSDSVIYYYQEADKEWKVLTQLPEgANAKGCAMcVLYNYLFLAGGILQGGPEGRARLsdkVFCYNPVTDTWTTVRSL 507
Cdd:PHA03098  400 KNDELLKTVECFSLNTNKWSKGSPLPI-SHYGGCAI-YHDGKIYVIGGISYIDNIKVYNI---VESYNPVTNKWTELSSL 474

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1788882369 508 NQPRSQLKLLALDGYLYAVGGECLFS----VERYDPRADRWSTVAPLPK 552
Cdd:PHA03098  475 NFPRINASLCIFNNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 4.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 52.52  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREIL-------RVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18259    34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVesisarvEIKDVDPAVMESLIDFAYTGKL-TINQGNVEALIRTSNR 112

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18259   113 LQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 6.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 51.83  E-value: 6.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREIL---RVKGVSYAALRLLVDYLYTGHMGEVKQ---DNVAEVIAGARFL 293
Cdd:cd18333    23 DVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLinlDHEMVSPGIFRLILDYIYTGRLSEGDPgseQNLGAVLAAASYL 102


                  ...
gi 1788882369 294 QMP 296
Cdd:cd18333   103 QIP 105
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 6.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 51.19  E-value: 6.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR---------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18245    16 DATLVVGGEEIPVQKNVLAAASPYFRAKlnynppkddGSTYKIELEGISVEVMEEILDYIYTGQI-KLSEDNIQDIVQAA 94


                  ....*
gi 1788882369 291 RFLQM 295
Cdd:cd18245    95 DLLLM 99
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 510-551 6.41e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 6.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1788882369 510 PRSQLKLLALDGYLYAVGG----ECLFSVERYDPRADRWSTVAPLP 551
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 7.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 51.77  E-value: 7.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQdNVAEVIAGARF 292
Cdd:cd18236    26 DVILCVDSQEFSCHRVVLAAASNYFRAmfcndlkEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQ-NVQRVLEAASL 104


                  ....
gi 1788882369 293 LQMP 296
Cdd:cd18236   105 FQFL 108
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-319 7.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 51.93  E-value: 7.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 292
Cdd:cd18270    28 DIVLIVEGTEFPCHKMVLATCSSYFRAmfmsglsESKQTHVHLRNVDAATLQIIITYAYTGNLA-INDSTVEQLYETACF 106

                          90       100
                  ....*....|....*....|....*..
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18270   107 LQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 8.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 51.35  E-value: 8.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA----RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 295
Cdd:cd18260    20 DLTIATKTKSFDVHKVVMASCSEYFRNilkkDPSLQRVELNDISPLGLATVITYAYTGKL-TLSLYTIGSTISAASYLQI 98

                          90       100
                  ....*....|....*....|
gi 1788882369 296 PCALQCATDAMRAQLTLSNC 315
Cdd:cd18260    99 HALVKMCCDFLMQEMNVENC 118
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 9.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 51.23  E-value: 9.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18338    23 DVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMsesrakrVRIKEVDGWTLKMLIDYVYTAEI-QVTEENVQVLLPAAGL 101

                          90
                  ....*....|....*...
gi 1788882369 293 LQMPCALQCATDAMRAQL 310
Cdd:cd18338   102 LQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 50.50  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA----------RSSREILRVkgVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAG 289
Cdd:cd18199    20 DCSIIVEGRIFKAHRNVLFASSGYFRMllshyiqdtgRPSTASFDV--FSSDAFSIILDFVYSGKL-SLTSQNVIEVMSA 96


                  ....*.
gi 1788882369 290 ARFLQM 295
Cdd:cd18199    97 ASYLQM 102
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 1.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 50.63  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR--------------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAE 285
Cdd:cd18228    21 DVTIRVQDKIFRAHKVVLAACSDFFRSKlvgqasprlvlvspAGKCVLDLHHVTVTGFAPLLEYAYTSTL-SINTENIID 99

                          90       100
                  ....*....|....*....|....*
gi 1788882369 286 VIAGARFLQMPCALQCATDAMRAQL 310
Cdd:cd18228   100 VLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 1.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 50.22  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI---LRVKGVSYAALRLLVDYLYTGHM--GEVKQDNVAEVIAGARFLQ 294
Cdd:cd18216    22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNlihLDQDMVSPTVFQQILDFIYTGKLldSLFEEPNLSEVLAAANYLQ 101


                  ..
gi 1788882369 295 MP 296
Cdd:cd18216   102 LP 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-308 2.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 50.41  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILrvKGVSYAALR------LLVDYLYTGHMGeVKQDNVAEVIAG 289
Cdd:cd18220    23 GKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTM--SGLSISVIKnpnvfeQLLSFCYTGRMS-LQLKDVVSFLTA 99

                          90
                  ....*....|....*....
gi 1788882369 290 ARFLQMPCALQCATDAMRA 308
Cdd:cd18220   100 ASFLQMQCVIDKCTQILES 118
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-319 2.49e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 50.34  E-value: 2.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 204 SISQSDPTGG--ALGEEP---DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLY 271
Cdd:cd18244    11 SIHDTSVSAGfrALYEEGlllDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMrerdqdkIHLKGLTATGFSHVLQFMY 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1788882369 272 TGHMgEVKQDNVAEVIAGARFLQMPCALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18244    91 YGTI-ELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 2.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 49.63  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR--SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVA--EVIAGARFLQM 295
Cdd:cd18303    20 DITIKLADKSIPAHKFVLAARSEKWSNEnlASTNELDLSDISYEVVLALLRWLYTDEL-DLTLDDEFllELMKAAKRFQL 98

                          90       100
                  ....*....|....*....|
gi 1788882369 296 PCALQCATDAMRAQLTLSNC 315
Cdd:cd18303    99 TDLVERCERALMSSVNVDNC 118
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 233-315 3.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 49.80  E-value: 3.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 233 HKSVLAAKSDYFRAR-----SSREILRVK--GVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPCALQCATDA 305
Cdd:cd18239    40 HRAMMASASDYFKAMftggmKEQELMCIKlhGVSKIGLKNIIDFIYTAKL-SLNMDNLQDTLEAASFLQILPVLDFCKVL 118

                          90
                  ....*....|
gi 1788882369 306 MRAQLTLSNC 315
Cdd:cd18239   119 LISGVTLENC 128
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-306 3.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 49.48  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR-------ARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSPEALTALLEFAYTATL-TVSTANVGDILSAARL 105

                          90
                  ....*....|....
gi 1788882369 293 LQMPCALQCATDAM 306
Cdd:cd18198   106 LEIPCVSHVCAEIL 119
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 220-330 4.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 49.61  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVA-GRRIQAHKSVLAAKSDYFR------ARSS---------REILRVKGVSYAALRLLVDYLYTGHMGEVKQDNV 283
Cdd:cd18310    20 DAEIIVEgGRPVPVHRCILAARSPFFRdifasaKAEGantkpklelRELIPGGIVGYDAFMLVLSYLYSGRLRLVPKEGS 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1788882369 284 AeviagarflqmpCA-LQCATDAMRA-------QLTLSNCYQV--LTLAKQQRLSEL 330
Cdd:cd18310   100 A------------CVdSDCWHVACRPavdfaleVLYAASVFQIpeLVSLFQRRLLDF 144
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 5.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 48.60  E-value: 5.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA---RSSREI--LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQ 294
Cdd:cd18217    20 DCTIVIGQFQFKAHRNVLAAFSEYFGAqykDTEDNIvfLDQSQVSADGFQKLLEFIYTGNL-NLDSWNVAEIHQAASYLG 98


                  ..
gi 1788882369 295 MP 296
Cdd:cd18217    99 ME 100
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-319 7.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 49.12  E-value: 7.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGhMGEVKQDNVAEVIAGARF 292
Cdd:cd18272    34 DVTISVEGKEFQLHRLVLSAQSCFFRSmftsnlkEARNRVIELKDVSESVFQLLVDYIYHG-TVKLRVEELQETYEVADM 112

                          90       100
                  ....*....|....*....|....*..
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNCYQVL 319
Cdd:cd18272   113 YQLTALFEECSRFLARTVQVRNCLQVM 139
Kelch smart00612
Kelch domain;
523-566 8.80e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 8.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1788882369  523 LYAVGG----ECLFSVERYDPRADRWSTVAPLPKGAFAVAheATTCNG 566
Cdd:smart00612   2 IYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHG--VAVING 47
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-315 9.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 48.56  E-value: 9.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAACSPYFRAMflsdleeSKKKEVVLEDVDPDVMGMILKYLYTSEI-DLNDQNVQDIFALASR 107

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18269   108 FQIPSIFTVCVSYLQKRLSLSNC 130
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 215-295 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 48.00  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 215 LGEEPDLVIEVAGRRIQAHKSVLAAKSDYFRAR--SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18206    19 LGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLfvDQKDVVHLDISNAAGLGQVLEFMYTAKL-SLSPENVDDVLAVATF 97


                  ...
gi 1788882369 293 LQM 295
Cdd:cd18206    98 LQM 100
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-315 1.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 48.05  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFR---ARSSREI-------LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEV 286
Cdd:cd18258    16 EFTDLKIIVEGKEFEVHQNVLASCSLYFKdliKRSSRDSgggekleLTMSNINADVLELLLEFVYTGSL-IIDSANAKTL 94

                          90       100
                  ....*....|....*....|....*....
gi 1788882369 287 IAGARFLQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18258    95 LEAANKFQFHTFCKVCVSFLEKQLTASNC 123
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 1.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 47.76  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQ----AHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTG--HMGEVkqdNVAEV 286
Cdd:cd18248    23 DVTLKVKYQDPKeefmAHKVVLASSSPYFKAmftsglrECGMEVVPIEGVHPCVMSRLIEFAYTAsiSVGEK---CVLHV 99

                          90       100
                  ....*....|....*....|....
gi 1788882369 287 IAGARFLQMPCALQCATDAMRAQL 310
Cdd:cd18248   100 LPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 1.98e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 47.18  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF------RARSSREILRV-KGVSYAALRLLVDYLYTGHMGEvKQDNVAEVIAGARF 292
Cdd:cd18215    21 DVVLVVGREQFRAHKTVLMACSGLFysiftdQLKNNVSVINLdPEIEPEGFRILLDFMYTSRLNL-REGNIMAVMATAMY 99


                  ....
gi 1788882369 293 LQMP 296
Cdd:cd18215   100 LQME 103
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 2.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 47.13  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR---ARSSREILRVKGVSYAALR-----LLVDYLYTGHMgEVKQDNVAEVIAGAR 291
Cdd:cd18329    23 DCSILVEGQVFKAHRNVLFASSGYFKmllSQNAKETGQPTVATFDVFSpdtftIILDFVYSGKL-SLTSQNVIEVMSAAS 101


                  ....
gi 1788882369 292 FLQM 295
Cdd:cd18329   102 YLQM 105
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-300 2.39e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 46.68  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR----SSREILRVKGVSyAALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQM 295
Cdd:cd18232    20 DATLDVGGRVFKAHWSVLACCSHFFQSLygdgTSGSVVLPESFA-EVFGLLLDFFYTGELA-LTRENRDRVLLAAKELRV 97


                  ....*
gi 1788882369 296 PCALQ 300
Cdd:cd18232    98 PEAVE 102
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 215-315 2.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 47.11  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 215 LGEEPDLVIEVAGRRIQAHKSVLAAKSDYFRAR--------SSREILrVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEV 286
Cdd:cd18276    18 LAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMftcglmecSQREVV-LHDITAESVSIILNYMYSSDL-HLTNSNVQGV 95

                          90       100
                  ....*....|....*....|....*....
gi 1788882369 287 IAGARFLQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18276    96 ATAAFFLQMEDIFSVCQKYMMDHMDASNC 124
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-295 3.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 47.27  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 204 SISQSDPTGGALGEEP------DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYL 270
Cdd:cd18261     8 SKSHKDAVLAALNQQRndgilcDITLVAEEQKFHAHKAVLAACSDYFRAmfslcmvESEADEVNLHGVTSLGLKQALDFA 87

                          90       100
                  ....*....|....*....|....*
gi 1788882369 271 YTGHMgEVKQDNVAEVIAGARFLQM 295
Cdd:cd18261    88 YTGQI-LLEPGVIQDVLAAGSHLQL 111
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 3.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 45.95  E-value: 3.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-SSREI---------LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAG 289
Cdd:cd18307     3 DVVISVDNHSFAAHRNVLAAVSPFVKSLiSSNDMkatdelsitIDCDYLSPETVEQLLDYFYTGKI-VISEKNVEDLLKG 81


                  ....*..
gi 1788882369 290 ARFLQMP 296
Cdd:cd18307    82 AKYFNIP 88
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-310 5.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 46.10  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA------RSSREILRVKGVSYAALR---LLVDYLYTGHMGEVKQdNVAEVIAGA 290
Cdd:cd18201    23 DVNIVVSGKVFRAHKNILVAGSRFFKTlycftnKESCDQTTVTHLDVVAVQgfsVILDFMYSGNLVLTSQ-NAIEVMSVA 101

                          90       100
                  ....*....|....*....|
gi 1788882369 291 RFLQMPCALQCATDAMRAQL 310
Cdd:cd18201   102 SYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-300 7.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 45.61  E-value: 7.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR-------ARSSRE-ILRVKGVSYAALRLLVDYLYTghmGEVKQD--NVAEVIAG 289
Cdd:cd18202    21 DVTLLIEGEEYKAHKSVLAANSEYFRelfiekgAVSSHEaVVDLSGFCKSSFLPLLEFAYT---SELTFDfcSMAEVAML 97

                          90
                  ....*....|.
gi 1788882369 290 ARFLQMPCALQ 300
Cdd:cd18202    98 ARHLFMNEVLE 108
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-299 9.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 45.27  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR------ARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRslfqnsSSQKNDVFHLDIKNVGGIGQILDFMYTSHL-DLNQDNVQVMLDIAQCL 98


                  ....*.
gi 1788882369 294 QMPCAL 299
Cdd:cd18233    99 QVQNVL 104
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 219-296 1.05e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 45.36  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 219 PDLVIEVAGRRIQAHKSVLAAKSDYFRA------------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEV 286
Cdd:cd18296    18 PDVCFQVEGHRFPCHKAFFCGRSDYFKAllrdhfaeseenNGSIPVVTLHDVSPEVFAIVLYYIYTDDT-DLPPENAYDV 96

                          90
                  ....*....|
gi 1788882369 287 IAGARFLQMP 296
Cdd:cd18296    97 LYVADMYLLP 106
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-307 1.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 45.22  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR--------------ARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAE 285
Cdd:cd18327    27 DLTIKTRGLEYRTHRAVLAACSLYFRklftgggggsgdlgAGGGQDVCELDFVGPEALGALLEFAYTATL-TISSSNMRE 105

                          90       100
                  ....*....|....*....|..
gi 1788882369 286 VIAGARFLQMPCALQCATDAMR 307
Cdd:cd18327   106 VLRAARLLEIPCVADACADILQ 127
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 215-306 1.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 45.02  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 215 LGEEPDLVIEVAGRRIQAHKSVLAAKSDYFR---ARSSREILRVKG-VSYAALRLLVDYLYTGHMGEVKQDNVAeVIAGA 290
Cdd:cd18289    26 MGLYCDVSIVVKGQAFKAHRAVLAASSLYFRdlfSGNSKSAFELPAtVPPACFQQILSFCYTGKLTMAASEQLV-VMYTA 104

                          90
                  ....*....|....*.
gi 1788882369 291 RFLQMPCALQCATDAM 306
Cdd:cd18289   105 GFLQIQHIVERGTDLM 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 45.27  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF--------RARSSREILRVkGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 291
Cdd:cd18266    27 DVVLVADEQRVPAHRNLLAVCSDYFnsmftigmREAHQKEVELV-GASYIGLKAVIDFLYSSEL-PLDGGNIDYVLETAH 104


                  ....
gi 1788882369 292 FLQM 295
Cdd:cd18266   105 LLQI 108
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 222-293 1.77e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 43.42  E-value: 1.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1788882369 222 VIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYtGHMGEVKQDNVAEVIAGARFL 293
Cdd:cd01165     2 VLVVEGEKFHVNKELLAQSSEYFRAlfrggfrESGQAEINLRDISPEDFRALLEFLY-GGKRDLDASNLLELLEAANFL 79
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.82e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 45.02  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVK-------GVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18246    41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRqthvtlhDIDPQALEQLVQYAYTAEI-VVGEGNVQTLLPAASL 119


                  ...
gi 1788882369 293 LQM 295
Cdd:cd18246   120 LQL 122
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 311-350 1.94e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 42.65  E-value: 1.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1788882369 311 TLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPS 350
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 225-315 1.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 44.82  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 225 VAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQMPC 297
Cdd:cd18252    29 ASGQIFHCHKAALAACSSYFKVmftadmkEKSNNVIKLSGIDHDILEALVNYVYTSQI-CITERNVQSLLEAADLLQFIS 107

                          90
                  ....*....|....*...
gi 1788882369 298 ALQCATDAMRAQLTLSNC 315
Cdd:cd18252   108 VKKACEQFLVRHLDIDNC 125
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 2.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 43.61  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRvvgqtdGDLVITLPEEVTVKGFEPLLQFAYTAKL-LLSKENVLEVCRCAEFL 81


                  ..
gi 1788882369 294 QM 295
Cdd:cd18955    82 GV 83
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 459-508 2.22e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 2.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1788882369 459 KGCAMCVLYNYLFLAGGIlqggpeGRARLSDKVFCYNPVTDTWTTVRSLN 508
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGF------DGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 310-377 2.23e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 43.99  E-value: 2.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1788882369 310 LTLSNCYQVLTLAKQQRLSELREAAYRFMSDNYLQVLREPSvYGRLTGSERDLILQRRMEaGRSCLLV 377
Cdd:cd18478     1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPE-FRPLPSSLKQQLRERRLR-GTPALVA 66
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 230-290 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 44.16  E-value: 2.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1788882369 230 IQAHKSVLAAKSDYFRA--------RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKqDNVAEVIAGA 290
Cdd:cd18294    28 IFAHKCILAARCEVFRAmfltgpqkESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSN-HTVIEVLAAA 95
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-293 2.54e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 44.29  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18277    29 DVTILVEGQRFRAHRSVLAACSSYFHSRivgqadAELNITLPEEVTVKGFEPLIQFAYTAKL-ILSKDNVDEVCKCVEFL 107
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 44.42  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF------RARSSREILRVKG--VSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGAR 291
Cdd:cd18956    25 DCTVLVGDARFPAHRAVLAACSVYFhlfyrdRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRL-DLRSLPVEDVLAAAS 103


                  ....
gi 1788882369 292 FLQM 295
Cdd:cd18956   104 YLHM 107
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 227-315 3.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 44.46  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 227 GRRIQAHKSVLAAKSDYF---------RARSSREILR----VKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA-RF 292
Cdd:cd18241    35 GREFRAHRSVLAAATEYFtpllsgqfsESRSGRVEMRkwssEPGPDPDTVEAVIQYMYTGRI-RVSTGNVHEVLELAdRF 113

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCAtDAMRAQLTLSNC 315
Cdd:cd18241   114 LLIRLKEFCG-EFLKKKLNLSNC 135
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 4.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 43.66  E-value: 4.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF----RAR-SSREILRVKG--VSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18194    25 DCTVLVGSAQFPAHRAVLASCSMYFhlfyRDRlDKRDLVRLNSdiVTAPAFGLLLDFMYEGRL-ALRDLPVEDVLAAASY 103


                  ...
gi 1788882369 293 LQM 295
Cdd:cd18194   104 LHM 106
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-315 4.53e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 43.26  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA------RSSRE-ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAmftsgmKESTQsVVQLPTIPAKDLRLLISFAYSGIL-HLSWENLFEATCTALQ 93

                          90       100
                  ....*....|....*....|...
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNC 315
Cdd:cd18263    94 LQISGALALCLDFLQREISPARC 116
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-273 5.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 43.01  E-value: 5.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTG 273
Cdd:cd18298    11 RTSDLKFRVDGKYIYVHKAILKIRCEYFRSmfqshwnEDDKNVIEIDQYSYPVYYAFLRYLYTD 74
Kelch_3 pfam13415
Galactose oxidase, central domain;
468-512 6.80e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 6.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1788882369 468 NYLFLAGGIlqgGPEGRARLSDkVFCYNPVTDTWTTVRSLNQPRS 512
Cdd:pfam13415   2 DKLYIFGGL---GFDGQTRLND-LYVYDLDTNTWTQIGDLPPPRS 42
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 42.72  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKGVSY----AALRLLVDYLYTGHMGeVKQDNVAEVIAGARFLQM 295
Cdd:cd18222    27 DIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISViknpTVFEQLLSFCYTGRIC-LQLADIISYLTAASFLQM 105
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-296 1.13e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.81  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR---SSREILRVKG-VSYAALRLLVDYLYTGHMGEVKqDNVAEVIAGARFLQM 295
Cdd:cd18262    20 DETVSVGGRSYGVHSVILAAVSSLFRERllgSNGPLPPLSLeVTPVGWEAVLTFAYTGVLGRNP-ATVGDILVAAEALGA 98


                  .
gi 1788882369 296 P 296
Cdd:cd18262    99 P 99
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-272 1.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 42.24  E-value: 1.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYT 272
Cdd:cd18353    19 ETSDLKFRVDGKYIHVHKAVLKIRCEHFRTmfqshwnEDMKEVIEIDQFSYPVYRAFLEYLYT 81
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 1.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 42.26  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA---RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQ---DNVAEVIAGARFL 293
Cdd:cd18334    23 DVIIVVENALFRAHKNILAASSMYFKSlvlHDNLINLDTDMVNPTVFRQILDFIYTGKLLTSDQpgeQNFNALLTAASYL 102


                  ...
gi 1788882369 294 QMP 296
Cdd:cd18334   103 QLH 105
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 223-294 1.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 41.40  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 223 IEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQDN---------VAEV 286
Cdd:cd18319     6 IRLEDRCYNVSKRKLIEQSDYFRAlyrsgmrESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDStdtleenelLEDL 85


                  ....*...
gi 1788882369 287 IAGARFLQ 294
Cdd:cd18319    86 VEAASFLQ 93
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-273 2.23e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 41.37  E-value: 2.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLYTG 273
Cdd:cd18345    20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMeerkqnrVEITDVDHEVMREMLRFIYTG 80
Kelch_6 pfam13964
Kelch motif;
510-553 2.31e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 2.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1788882369 510 PRSQLKLLALDGYLYAVGGECLFS-----VERYDPRADRWSTVAPLPKG 553
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpalnkLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 206-315 2.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.50  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 206 SQSDPTGGALGEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA----RSSRE--ILRVKGVSYAALRLLVDYLYTGHMGE-- 277
Cdd:cd18351    12 SRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKAllsnKPSAEntCIEISYVKYHIFQLVMQYLYCGGTESll 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1788882369 278 VKQDNVAEVIAGARFLQMP-----CALQCATDamraqLTLSNC 315
Cdd:cd18351    92 IKNNEIMELLSAAKFFQLEalqrhCEIICAKS-----INTENC 129
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-318 2.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 41.76  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREILRVKG-------VSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18341    29 DCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKkevvldnVDPNIMDMILKYLYSAEI-DLNDGNVQDIFALASR 107

                          90       100
                  ....*....|....*....|....*.
gi 1788882369 293 LQMPCALQCATDAMRAQLTLSNCYQV 318
Cdd:cd18341   108 FQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 3.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 40.82  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR-----SSREILRVkgVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQ 294
Cdd:cd18208    27 DVTVRIHGSMLRAHRCVLAAGSPFFQDKlllgySDIEIPSV--VSVQSVQKLIDFMYSGVL-RVSQSEALQILTAASILQ 103


                  .
gi 1788882369 295 M 295
Cdd:cd18208   104 I 104
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-306 3.88e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 40.63  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18328    27 DVVLIVQDQEYRTHRSVLAACSKYFKKlftagtlADQPYVYEIDFVTPEALSAILEFAYTSTL-TITTSNVKHILNAAQM 105

                          90
                  ....*....|....
gi 1788882369 293 LQMPCALQCATDAM 306
Cdd:cd18328   106 LEIQCIINVCLEIM 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-273 4.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 40.59  E-value: 4.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLYTG 273
Cdd:cd18279    20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMeeskknrVEINDVDPEVFKEMMRFIYTG 80
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 220-245 4.47e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 39.96  E-value: 4.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR 245
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFR 45
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 4.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 40.55  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSRE------ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMFADEgevgqsIYMLEGMVAETFGALLEFIYTGCL-QVGEKSLEQILATAQFL 103


                  ...
gi 1788882369 294 QMP 296
Cdd:cd18212   104 KVN 106
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 213-290 4.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 40.71  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 213 GALGEEP---DLVIEVAGRRIQAHKSVLAAKSDYFRARSSREI-------LRVKGVSYAALRLLVDYLYTGHMGEVKQDN 282
Cdd:cd18344    15 GELWENSlftDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMeerlknpIEIHDLDPQVFKEMMGFIYTGKAPHLHSHS 94


                  ....*....
gi 1788882369 283 VA-EVIAGA 290
Cdd:cd18344    95 MAcDVLAAA 103
Kelch_6 pfam13964
Kelch motif;
464-511 6.00e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 6.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1788882369 464 CVLY-NYLFLAGGILQGGPegrarLSDKVFCYNPVTDTWTTVRSLNQPR 511
Cdd:pfam13964   7 VVSVgGYIYVFGGYTNASP-----ALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 9.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 40.02  E-value: 9.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR-----ARSSREILRVKG--VSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARF 292
Cdd:cd18325    25 DCTVLVGEAQFRAHRAVLASCSMYFHlfyrdQLDKRDIVHLNSdiVTAPAFSLLLEFMYEGKL-EFSSLPVEDVLAAASY 103


                  ...
gi 1788882369 293 LQM 295
Cdd:cd18325   104 LHM 106
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 220-297 9.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 38.86  E-value: 9.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 292
Cdd:cd18314     8 DVVLCVGDRKFFAHRIVLCARSPVFRSmltgsmiESNLKEVTLEDVEPEIFETVLKYMYTGQVT-LSEENVLDLLMLASK 86


                  ....*
gi 1788882369 293 LQMPC 297
Cdd:cd18314    87 YQVPD 91
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 39.45  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA-------RSSREILRVKGVSYAALRLLVDYLYTGHMGeVKQDNVAEVIAGARF 292
Cdd:cd18331    26 DVVIVVSREQFRAHKTVLMACSGLFYSiftdqlkCNLSVINLDPEINPEGFNILLDFMYTSRLN-LREGNIMAVMATAMY 104


                  ...
gi 1788882369 293 LQM 295
Cdd:cd18331   105 LQM 107
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 559-593 1.24e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1788882369 559 HEATTCNGEIYVSGGSLFYRLLK----YDPRRDEWQECP 593
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQSLNsvevYDPETNTWSKLP 43
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 39.56  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA---------RSSREiLRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18207    29 DVLLRVGEESFPAHRAVLAACSEYFESvfsaqegdgGTPRE-LEMHTISSKVFGDILDFAYTSRI-VVRLESFPELMTAA 106


                  ....*
gi 1788882369 291 RFLQM 295
Cdd:cd18207   107 KFLLM 111
PRK14131 PRK14131
N-acetylneuraminate epimerase;
509-574 1.33e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 1.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1788882369 509 QPRSQLKLLALDGYLYAVGG----------ECLFSVERYDPRADRWSTVAPLPKGAFAVAHEATTCNGEIYVSGGS 574
Cdd:PRK14131   73 GPREQAVAAFIDGKLYVFGGigktnsegspQVFDDVYKYDPKTNSWQKLDTRSPVGLAGHVAVSLHNGKAYITGGV 148
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.77  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSSRE----ILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFLQM 295
Cdd:cd18218    20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTNPnpgqWCLGEGISPSTFKQLLDFVYGESV-EVQPGELRPLLEAARALEV 98
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 220-290 1.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 37.88  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRAR---SSREILRV------KGVSYAALRLLVDYLYTGHMGEVKQDNVAEVIAGA 290
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMlygNFRESTSDcidfeeNGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80
PRK14131 PRK14131
N-acetylneuraminate epimerase;
440-504 1.76e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.15  E-value: 1.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1788882369 440 QEADKEWKVLTQLPEGANaKGCAMCVLYNYLFLAGGILQGGPEGRARLSDKVFCYNPVTDTWTTV 504
Cdd:PRK14131   58 NAPSKGWTKIAAFPGGPR-EQAVAAFIDGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKL 121
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 1.78e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 39.16  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF------RARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGARFL 293
Cdd:cd18278    33 DVTLIVEGKEFRAHRAVLAACSEYFlqalvgQTENDLVVSLPEEVTARGFGPLLQFAYTAKL-LLSRENIQEVIRCAEFL 111


                  ..
gi 1788882369 294 QM 295
Cdd:cd18278   112 RM 113
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-296 1.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 38.27  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARSS--REILRVKGVSYAALRLLVDYLYTGHMGEVKQDNVAEVIAGARFLQMP 296
Cdd:cd18219    23 DVTVIVEDRKFRAHKNILSASSTYFHQLFSvaGQVVELNFIRADIFAEILNYIYSSKIVRVRSDLLEELIKSGQLLGVK 101
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 216-295 2.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 38.08  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRAR------SSREILRVKGV--SYAALRLLVDYLYtGHMGEVKQDNVAEVI 287
Cdd:cd18312     7 GEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLasssseSDPSEIELNDFpgGAEAFELVAKFCY-GMPINLTATNVVGLR 85


                  ....*...
gi 1788882369 288 AGARFLQM 295
Cdd:cd18312    86 CAAEYLEM 93
Kelch smart00612
Kelch domain;
470-512 2.63e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 2.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1788882369  470 LFLAGGIlqggpeGRARLSDKVFCYNPVTDTWTTVRSLNQPRS 512
Cdd:smart00612   2 IYVVGGF------DGGQRLKSVEVYDPETNKWTPLPSMPTPRS 38
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 217-283 2.75e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 38.38  E-value: 2.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 217 EEPDLVIEVAGRRIQAHKSVLAAKSDYFRA---RSSREILRVKGVSYAALRLLVDYLYTGHMGEVKQDNV 283
Cdd:cd18354    19 DTADLKFLVDGKYIYVHKVLLKIRCEHFRSllnENEEEIIEMSQFSYPVYRAFLEYLYTDSISLSPEDAI 88
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 220-290 3.57e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 37.84  E-value: 3.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRA--------RSSREIlRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAmfdggyreKEARDI-EIPNIRWEVFELMMRFIYTGSV-DITNDIAKDLLRAA 91
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 215-295 3.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 38.00  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 215 LGEEPDLVIEVAGRRIQAHKSVLAAKSDYF----RARSSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEVIAGA 290
Cdd:cd18227    22 QGQLCDISVVVQGHLFRAHKAVLAASSPYFcdqvLLKNSRRIVLPDVMNPRVFENILLSCYTGRL-VLPAPEIVSYLTAA 100


                  ....*
gi 1788882369 291 RFLQM 295
Cdd:cd18227   101 SFLQM 105
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 218-272 3.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 37.46  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1788882369 218 EPDLVIEVAGRR-IQAHKSVLAAKSDYF-------RARSSREILRVKGVSYAALRLLVDYLYT 272
Cdd:cd18313     1 GADVEIETDNNShIPAHSNVLASASPVIagmlkqpRRKSSKKVIKILGVPCDAVRVFIRFLYS 63
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-244 5.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.14  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYF 244
Cdd:cd18200    20 DLSVHVQGRVFRAHKAVLAASSPYF 44
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-246 6.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 37.31  E-value: 6.45e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA 246
Cdd:cd18280    12 EEGADVTFNVDGEKFRAHKLVLAARSPVFRS 42
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-295 7.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 37.33  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRA-----RSSREI----LRVKGVSYAALRLLVDYLYTGHMgEVKQDNVAEV 286
Cdd:cd18196    19 GQLCDCVIVVGNRHFKAHRSVLAACSTHFRAlftvaEGDQTMnmiqLDSEVVTAEAFAALIDMMYTSTL-MLGESNVMDV 97


                  ....*....
gi 1788882369 287 IAGARFLQM 295
Cdd:cd18196    98 LLAASHLHL 106
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-295 9.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 36.74  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFRARssreiLRVKGVSYAALRLLVDYL---------YTGHMGEVKQDNVAEVIAGA 290
Cdd:cd18210    23 DISIHVQGRVFRAHRAVLAASSPYFHDQ-----VLLKNMSSISLPGVMDPGafesvlasaYTGKLTMLADEIVNYLTVGS 97


                  ....*
gi 1788882369 291 rFLQM 295
Cdd:cd18210    98 -VLQM 101
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 216-298 9.38e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 36.55  E-value: 9.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 216 GEEPDLVIEVAGRRIQAHKSVLAAKSDYFRAR------SSREILRVKGVSYAALRLLVDYLYTGHMgEVKQDNV-----A 284
Cdd:cd18204    16 GEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLfkklevDSSSVIEIDFLRSDIFEEVLNYMYTAKI-SVKKEDVnlmmsS 94

                          90
                  ....*....|....
gi 1788882369 285 EVIAGARFLQMPCA 298
Cdd:cd18204    95 GQILGIRFLDKLCS 108
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 220-297 9.86e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 36.79  E-value: 9.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788882369 220 DLVIEVAGRRIQAHKSVLAAKSDYFR--------------------ARSSREILRVKGVSYAALRLLVDYLYTGHMGEVK 279
Cdd:cd18195    20 DVTLIAGDTKFRAHRSVLAASSPYFRellssplplgaaavaaapgaTQSPERVLELPGVKAGVFSDVLNFIYSSRVALPG 99

                          90
                  ....*....|....*...
gi 1788882369 280 QDNVAEVIAGARFLQMPC 297
Cdd:cd18195   100 SAAAKELGAAGKRLGIPF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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