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Conserved domains on  [gi|1788866386|ref|XP_031795305|]
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adenomatous polyposis coli protein isoform X3 [Sarcophilus harrisii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 673-958 4.05e-167

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 516.45  E-value: 4.05e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  673 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRNKQRHKQNLYSEYAFDINRHEEN-- 750
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  751 RSDNFNTGNMTVLSPYLNTTVLPASSS---RTNLESSRSEKDRSLDRERGIGLNTFHPATENSGNSSKRIGLQISTATAQ 827
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdsRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  828 IAKVMEEVSGIHV-QEDQGSGSSTELHCIAEDRSTLRRASATLAHSNTYNFPKSDNSNRTCPMPYAKMEYKRSSNDSLNS 906
Cdd:pfam16629  161 IAKVMEEVSSMHIsQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386  907 VSSSDGYGKRGQMKPSIESYSGDDESKFCSYGQYPADLAHKIHSANHMDDND 958
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2163-2508 6.36e-93

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 305.65  E-value: 6.36e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2163 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPASKSPSEGPASSTS-PRGGKPAVKSELSPLTRQTSQPGGSSKGPSR 2241
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2242 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLNKQ 2321
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2322 TGLSKNTSNI------PRSESASKGLNqitssNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2395
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2396 LEESASFESLssssrpespTRSQVQTPVLS-PSLPDMSSSTHSSIQTGGWRKLPPNLNPAIEFNDGRSTKRHDIARSHSE 2474
Cdd:pfam05956  226 LELSASESLS---------PSSQPASPRRSrPGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSE 296

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1788866386 2475 SPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2508
Cdd:pfam05956  297 SPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2610-2785 7.70e-82

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 266.86  E-value: 7.70e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2610 RSGRSPTGNTPPVIDTVSEKVNSSNKDPKDNQGKPNGGNGSssAPARTVGLENRLNSFIQIDSPDKKATETKSGQGNIVP 2689
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN--VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2690 TPETSETSITERTPFSSTNSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTENTESSG 2769
Cdd:pfam05937   79 TPETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSG 158

                          170
                   ....*....|....*.
gi 1788866386 2770 AQSPKRHSGSYLVTSV 2785
Cdd:pfam05937  159 NQSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 976-1075 1.14e-53

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 183.18  E-value: 1.14e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  976 LNSGRQSPSQNERWARPKHIIEDEIKQNEQRQSRGQNASFSAYSESTDEKHIKFQSRFGQQECVSPYRSRGANGSEQNRV 1055
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 1788866386 1056 NSNHGLNQKVNQSLCHEDDY 1075
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 334-407 6.42e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 6.42e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788866386  334 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 407
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1687-1779 9.72e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 151.92  E-value: 9.72e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1687 IMDQIQQASTSSSGNSKSPLDNEKKKPTSPVKPMPQSVEYRTRIRKNAESK-NLNIERSYSDNKDSKKLNLKNNPRDFID 1765
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 1788866386 1766 KLPNNEERVRGSFT 1779
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1224-1310 7.01e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 149.25  E-value: 7.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1224 AEDEI-GRDQTTRGTETSNNLQIAELKENSGSVSTDDTISEVPSTSQHIRTKANRLQTTSLSPSDSARHKAVEFSSGAKS 1302
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1788866386 1303 PAKSGAQT 1310
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1816-1886 1.17e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 119.58  E-value: 1.17e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788866386 1816 REKAEL-KGKEAKETETKVNNHIELTSNQQPSNRTQICTKQPIDRNQSKPLLQKQSTFPQPSKDLPDRGAAT 1886
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1603-1656 1.84e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 103.72  E-value: 1.84e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1788866386 1603 IESPPNELAVIESTGTAGAQLEFEKRDTIPTEGRSTDDIQTGKIPNITTSALDD 1656
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 68-148 7.89e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 7.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386   68 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 146
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 1788866386  147 TC 148
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1578-1601 1.99e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....
gi 1788866386 1578 DMPRVYCVEGTPINFSTATSLSDL 1601
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 590-630 1.68e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 1.68e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1788866386   590 NEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 630
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1973-1992 9.60e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.60e-06
                           10        20
                   ....*....|....*....|
gi 1788866386 1973 DSEDDLLQECISSAMPKKKR 1992
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 453-494 5.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1788866386   453 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 494
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 632-672 2.37e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  632 NTKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 672
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1660-1678 3.33e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.33e-03
                           10
                   ....*....|....*....
gi 1788866386 1660 EEGEILAECINSAMPKGKS 1678
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1313-1335 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 1788866386 1313 SPPEHY-VQETPLMFSRCTSVSSL 1335
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 400-451 4.85e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.85e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386   400 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 281-333 7.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 7.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1788866386   281 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 333
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1198-1215 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 1788866386 1198 ETIQTYCVEDTPICFSRC 1215
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 673-958 4.05e-167

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 516.45  E-value: 4.05e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  673 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRNKQRHKQNLYSEYAFDINRHEEN-- 750
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  751 RSDNFNTGNMTVLSPYLNTTVLPASSS---RTNLESSRSEKDRSLDRERGIGLNTFHPATENSGNSSKRIGLQISTATAQ 827
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdsRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  828 IAKVMEEVSGIHV-QEDQGSGSSTELHCIAEDRSTLRRASATLAHSNTYNFPKSDNSNRTCPMPYAKMEYKRSSNDSLNS 906
Cdd:pfam16629  161 IAKVMEEVSSMHIsQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386  907 VSSSDGYGKRGQMKPSIESYSGDDESKFCSYGQYPADLAHKIHSANHMDDND 958
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2163-2508 6.36e-93

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 305.65  E-value: 6.36e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2163 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPASKSPSEGPASSTS-PRGGKPAVKSELSPLTRQTSQPGGSSKGPSR 2241
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2242 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLNKQ 2321
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2322 TGLSKNTSNI------PRSESASKGLNqitssNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2395
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2396 LEESASFESLssssrpespTRSQVQTPVLS-PSLPDMSSSTHSSIQTGGWRKLPPNLNPAIEFNDGRSTKRHDIARSHSE 2474
Cdd:pfam05956  226 LELSASESLS---------PSSQPASPRRSrPGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSE 296

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1788866386 2475 SPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2508
Cdd:pfam05956  297 SPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2610-2785 7.70e-82

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 266.86  E-value: 7.70e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2610 RSGRSPTGNTPPVIDTVSEKVNSSNKDPKDNQGKPNGGNGSssAPARTVGLENRLNSFIQIDSPDKKATETKSGQGNIVP 2689
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN--VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2690 TPETSETSITERTPFSSTNSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTENTESSG 2769
Cdd:pfam05937   79 TPETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSG 158

                          170
                   ....*....|....*.
gi 1788866386 2770 AQSPKRHSGSYLVTSV 2785
Cdd:pfam05937  159 NQSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 976-1075 1.14e-53

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 183.18  E-value: 1.14e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  976 LNSGRQSPSQNERWARPKHIIEDEIKQNEQRQSRGQNASFSAYSESTDEKHIKFQSRFGQQECVSPYRSRGANGSEQNRV 1055
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 1788866386 1056 NSNHGLNQKVNQSLCHEDDY 1075
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 334-407 6.42e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 6.42e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788866386  334 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 407
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1687-1779 9.72e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 151.92  E-value: 9.72e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1687 IMDQIQQASTSSSGNSKSPLDNEKKKPTSPVKPMPQSVEYRTRIRKNAESK-NLNIERSYSDNKDSKKLNLKNNPRDFID 1765
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 1788866386 1766 KLPNNEERVRGSFT 1779
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1224-1310 7.01e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 149.25  E-value: 7.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1224 AEDEI-GRDQTTRGTETSNNLQIAELKENSGSVSTDDTISEVPSTSQHIRTKANRLQTTSLSPSDSARHKAVEFSSGAKS 1302
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1788866386 1303 PAKSGAQT 1310
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1816-1886 1.17e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 119.58  E-value: 1.17e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788866386 1816 REKAEL-KGKEAKETETKVNNHIELTSNQQPSNRTQICTKQPIDRNQSKPLLQKQSTFPQPSKDLPDRGAAT 1886
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1603-1656 1.84e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 103.72  E-value: 1.84e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1788866386 1603 IESPPNELAVIESTGTAGAQLEFEKRDTIPTEGRSTDDIQTGKIPNITTSALDD 1656
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 68-148 7.89e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 7.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386   68 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 146
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 1788866386  147 TC 148
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1578-1601 1.99e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....
gi 1788866386 1578 DMPRVYCVEGTPINFSTATSLSDL 1601
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 590-630 1.68e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 1.68e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1788866386   590 NEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 630
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 590-630 1.80e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 1.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  590 NEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 630
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2196-2317 4.75e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2196 PASKSPSEGPASSTSPRGGKPAVKSELSPLTRQTSQPGGSSKGPSRSG----SRDSTPSRPSQQPLSRPMQSPGRNSISP 2271
Cdd:PHA03307   278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSssstSSSSESSRGAAVSPGPSPSRSPSPSRPP 357

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1788866386 2272 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQN 2317
Cdd:PHA03307   358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRD 402
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1973-1992 9.60e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.60e-06
                           10        20
                   ....*....|....*....|
gi 1788866386 1973 DSEDDLLQECISSAMPKKKR 1992
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 453-494 5.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1788866386   453 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 494
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 453-493 5.92e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 5.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  453 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 493
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 632-672 2.37e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  632 NTKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 672
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1660-1678 3.33e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.33e-03
                           10
                   ....*....|....*....
gi 1788866386 1660 EEGEILAECINSAMPKGKS 1678
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1313-1335 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 1788866386 1313 SPPEHY-VQETPLMFSRCTSVSSL 1335
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 400-451 4.85e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.85e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386   400 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 281-333 7.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 7.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1788866386   281 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 333
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1198-1215 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 1788866386 1198 ETIQTYCVEDTPICFSRC 1215
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 2097-2352 9.73e-03

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 41.42  E-value: 9.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2097 KPFTSNKGPRILKPGEKSTLETKKI-ESENKGIKGGKkvykslITGKVRSNSEVSSQLKQPLQTNMPSISRGRTMIHIPG 2175
Cdd:COG5422     30 QLLPPRRLQRKLNPISIRNGADNDIiNSESKESFGKY------ALGHQIFSSFSSSPKLFQRRNSAGPITHSPSATSSTS 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2176 IRNSSSSTSPVSKKGPSLKTPASK--SPSEGPASSTSPRGGK----PAVKSELSPLTRQTSQPGGSSKGPSRSGSRDSTP 2249
Cdd:COG5422    104 SLNSNDGDQFSPASDSLSFNPSSTqsRKDSGPGDGSPVQKRKnpllPSSSTHGTHPPIVFTDNNGSHAGAPNARSRKEIP 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2250 SRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPgrqmsqqnlnkqtglSKNTS 2329
Cdd:COG5422    184 SLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLLKRHSG---------------SSGAS 248

                          250       260
                   ....*....|....*....|...
gi 1788866386 2330 NIpRSESASKGLNQITSSNGTNK 2352
Cdd:COG5422    249 LI-SSNITPSSSNSEAMSTSSKR 270
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 673-958 4.05e-167

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 516.45  E-value: 4.05e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  673 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRNKQRHKQNLYSEYAFDINRHEEN-- 750
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  751 RSDNFNTGNMTVLSPYLNTTVLPASSS---RTNLESSRSEKDRSLDRERGIGLNTFHPATENSGNSSKRIGLQISTATAQ 827
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrdsRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  828 IAKVMEEVSGIHV-QEDQGSGSSTELHCIAEDRSTLRRASATLAHSNTYNFPKSDNSNRTCPMPYAKMEYKRSSNDSLNS 906
Cdd:pfam16629  161 IAKVMEEVSSMHIsQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386  907 VSSSDGYGKRGQMKPSIESYSGDDESKFCSYGQYPADLAHKIHSANHMDDND 958
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2163-2508 6.36e-93

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 305.65  E-value: 6.36e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2163 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPASKSPSEGPASSTS-PRGGKPAVKSELSPLTRQTSQPGGSSKGPSR 2241
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2242 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLNKQ 2321
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2322 TGLSKNTSNI------PRSESASKGLNqitssNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2395
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2396 LEESASFESLssssrpespTRSQVQTPVLS-PSLPDMSSSTHSSIQTGGWRKLPPNLNPAIEFNDGRSTKRHDIARSHSE 2474
Cdd:pfam05956  226 LELSASESLS---------PSSQPASPRRSrPGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSE 296

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1788866386 2475 SPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2508
Cdd:pfam05956  297 SPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2610-2785 7.70e-82

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 266.86  E-value: 7.70e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2610 RSGRSPTGNTPPVIDTVSEKVNSSNKDPKDNQGKPNGGNGSssAPARTVGLENRLNSFIQIDSPDKKATETKSGQGNIVP 2689
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN--VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2690 TPETSETSITERTPFSSTNSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTENTESSG 2769
Cdd:pfam05937   79 TPETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSG 158

                          170
                   ....*....|....*.
gi 1788866386 2770 AQSPKRHSGSYLVTSV 2785
Cdd:pfam05937  159 NQSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 976-1075 1.14e-53

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 183.18  E-value: 1.14e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386  976 LNSGRQSPSQNERWARPKHIIEDEIKQNEQRQSRGQNASFSAYSESTDEKHIKFQSRFGQQECVSPYRSRGANGSEQNRV 1055
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 1788866386 1056 NSNHGLNQKVNQSLCHEDDY 1075
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 334-407 6.42e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 6.42e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788866386  334 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 407
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1687-1779 9.72e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 151.92  E-value: 9.72e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1687 IMDQIQQASTSSSGNSKSPLDNEKKKPTSPVKPMPQSVEYRTRIRKNAESK-NLNIERSYSDNKDSKKLNLKNNPRDFID 1765
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 1788866386 1766 KLPNNEERVRGSFT 1779
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1224-1310 7.01e-42

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 149.25  E-value: 7.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 1224 AEDEI-GRDQTTRGTETSNNLQIAELKENSGSVSTDDTISEVPSTSQHIRTKANRLQTTSLSPSDSARHKAVEFSSGAKS 1302
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 1788866386 1303 PAKSGAQT 1310
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1816-1886 1.17e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 119.58  E-value: 1.17e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788866386 1816 REKAEL-KGKEAKETETKVNNHIELTSNQQPSNRTQICTKQPIDRNQSKPLLQKQSTFPQPSKDLPDRGAAT 1886
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1603-1656 1.84e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 103.72  E-value: 1.84e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1788866386 1603 IESPPNELAVIESTGTAGAQLEFEKRDTIPTEGRSTDDIQTGKIPNITTSALDD 1656
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 68-148 7.89e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 7.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386   68 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 146
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 1788866386  147 TC 148
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1578-1601 1.99e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....
gi 1788866386 1578 DMPRVYCVEGTPINFSTATSLSDL 1601
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 590-630 1.68e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 1.68e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1788866386   590 NEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 630
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 590-630 1.80e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 1.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  590 NEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 630
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2196-2317 4.75e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 4.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2196 PASKSPSEGPASSTSPRGGKPAVKSELSPLTRQTSQPGGSSKGPSRSG----SRDSTPSRPSQQPLSRPMQSPGRNSISP 2271
Cdd:PHA03307   278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSssstSSSSESSRGAAVSPGPSPSRSPSPSRPP 357

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1788866386 2272 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQN 2317
Cdd:PHA03307   358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRD 402
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1973-1992 9.60e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.12  E-value: 9.60e-06
                           10        20
                   ....*....|....*....|
gi 1788866386 1973 DSEDDLLQECISSAMPKKKR 1992
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2191-2504 3.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 3.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2191 PSLKTPASKSPSEGPASSTSP-----RGGKPAvkSELSPLTRQTSQPGGSSKGPSRSGSRDSTPSRPSQQPLSRPMQSPG 2265
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPgpaaaRQASPA--LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2266 RNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnlnkqTGLSKNTSNIPRSESASKGLNQIT 2345
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPPS 2849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2346 SS-------NGTNKKVELSRMSSTKSSGSESDRSER---PVLVRQSTFIKETPSPTLRRKLEESASFESLSSSSRPESPT 2415
Cdd:PHA03247  2850 LPlggsvapGGDVRRRPPSRSPAAKPAAPARPPVRRlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2416 RSQVQTPVLSPslPDMSSSTHSSIQTGGWRKLPPNLNPAIEFNDGRSTKRhdiaRSHSESPSRlPINRSGTwkreHSKHS 2495
Cdd:PHA03247  2930 QPPPPPPPRPQ--PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF----RVPQPAPSR-EAPASST----PPLTG 2998


                   ....*....
gi 1788866386 2496 SSLPRVSTW 2504
Cdd:PHA03247  2999 HSLSRVSSW 3007
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 453-494 5.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1788866386   453 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 494
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 453-493 5.92e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 5.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  453 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 493
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2156-2311 1.75e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2156 PLQTNMPSISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPASKSPSEG-PASSTSPRGGK---------PAVKSELSPL 2225
Cdd:PHA03307   256 PLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGsGPAPSSPRASSsssssressSSSTSSSSES 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2226 TRQTSQPGGSSKGPSRSGSRDS----TPSRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGS 2301
Cdd:PHA03307   336 SRGAAVSPGPSPSRSPSPSRPPppadPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPS 415

                          170
                   ....*....|
gi 1788866386 2302 GKMSYTSPGR 2311
Cdd:PHA03307   416 PLDAGAASGA 425
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 632-672 2.37e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1788866386  632 NTKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 672
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1660-1678 3.33e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.33e-03
                           10
                   ....*....|....*....
gi 1788866386 1660 EEGEILAECINSAMPKGKS 1678
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1313-1335 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 1788866386 1313 SPPEHY-VQETPLMFSRCTSVSSL 1335
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 400-451 4.85e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.85e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1788866386   400 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 281-333 7.94e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 7.94e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1788866386   281 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 333
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1198-1215 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 1788866386 1198 ETIQTYCVEDTPICFSRC 1215
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 2097-2352 9.73e-03

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 41.42  E-value: 9.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2097 KPFTSNKGPRILKPGEKSTLETKKI-ESENKGIKGGKkvykslITGKVRSNSEVSSQLKQPLQTNMPSISRGRTMIHIPG 2175
Cdd:COG5422     30 QLLPPRRLQRKLNPISIRNGADNDIiNSESKESFGKY------ALGHQIFSSFSSSPKLFQRRNSAGPITHSPSATSSTS 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2176 IRNSSSSTSPVSKKGPSLKTPASK--SPSEGPASSTSPRGGK----PAVKSELSPLTRQTSQPGGSSKGPSRSGSRDSTP 2249
Cdd:COG5422    104 SLNSNDGDQFSPASDSLSFNPSSTqsRKDSGPGDGSPVQKRKnpllPSSSTHGTHPPIVFTDNNGSHAGAPNARSRKEIP 183

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788866386 2250 SRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPgrqmsqqnlnkqtglSKNTS 2329
Cdd:COG5422    184 SLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIRKNSRHSSNSMPSFPHSSTAVLLKRHSG---------------SSGAS 248

                          250       260
                   ....*....|....*....|...
gi 1788866386 2330 NIpRSESASKGLNQITSSNGTNK 2352
Cdd:COG5422    249 LI-SSNITPSSSNSEAMSTSSKR 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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