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Conserved domains on  [gi|1784558426|ref|WP_157061466|]
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phosphopantetheine-binding protein, partial [Legionella cincinnatiensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12467 super family cl36129
peptide synthase; Provisional
 4-85 1.34e-21

peptide synthase; Provisional


The actual alignment was detected with superfamily member PRK12467:

Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 87.52  E-value: 1.34e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    4 PEAAQGQRrDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRlQLQVSVKDLFSCRTLR 83
Cdd:PRK12467  2082 PDASELQQ-AYVAPQSELEQRLAAIWQDVLGLEQVGL--HDNFFELGGDSIISIQVVSRARQA-GIRFTPKDLFQHQTVQ 2157


                   ..
gi 1784558426   84 RL 85
Cdd:PRK12467  2158 SL 2159
 
Name Accession Description Interval E-value
PRK12467 PRK12467
peptide synthase; Provisional
 4-85 1.34e-21

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 87.52  E-value: 1.34e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    4 PEAAQGQRrDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRlQLQVSVKDLFSCRTLR 83
Cdd:PRK12467  2082 PDASELQQ-AYVAPQSELEQRLAAIWQDVLGLEQVGL--HDNFFELGGDSIISIQVVSRARQA-GIRFTPKDLFQHQTVQ 2157


                   ..
gi 1784558426   84 RL 85
Cdd:PRK12467  2158 SL 2159
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 17-92 1.93e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 69.88  E-value: 1.93e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1784558426 17 PSTELEQQLSVIWSEVLGIKAGGLSVHDDFFR-LGGDSIISIQLISRIRQRLQLQVSVKDLFSCRTLRRLHEHLVAR 92
Cdd:COG0236    2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 23-83 1.19e-16

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 67.59  E-value: 1.19e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784558426 23 QQLSVIWSEVLGIKAGGLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCRTLR 83
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 3-92 3.78e-10

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 51.48  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426   3 LPEAAQGQRRDyelpstELEQQLSVIWSEVLGIKAGG-LSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCRT 81
Cdd:smart00823  1 LAALPPAERRR------LLLDLVREQVAAVLGHAAAEaIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPT 74

                          90
                  ....*....|.
gi 1784558426  82 LRRLHEHLVAR 92
Cdd:smart00823 75 PAALAEHLAAE 85
alpha_am_amid TIGR03443
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...
 1-83 1.16e-09

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.


Pssm-ID: 274582 [Multi-domain]  Cd Length: 1389  Bit Score: 53.53  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQRRDYELPS-TELEQQLSVIWSEVLGIKAGGLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSC 79
Cdd:TIGR03443  828 AQLAAVAKNRSASAADEEfTETEREIRDLWLELLPNRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELPLGLIFKS 907


                   ....
gi 1784558426   80 RTLR 83
Cdd:TIGR03443  908 PTIK 911
 
Name Accession Description Interval E-value
PRK12467 PRK12467
peptide synthase; Provisional
 4-85 1.34e-21

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 87.52  E-value: 1.34e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    4 PEAAQGQRrDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRlQLQVSVKDLFSCRTLR 83
Cdd:PRK12467  2082 PDASELQQ-AYVAPQSELEQRLAAIWQDVLGLEQVGL--HDNFFELGGDSIISIQVVSRARQA-GIRFTPKDLFQHQTVQ 2157


                   ..
gi 1784558426   84 RL 85
Cdd:PRK12467  2158 SL 2159
PRK12316 PRK12316
peptide synthase; Provisional
 3-95 7.80e-21

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 85.39  E-value: 7.80e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    3 LPEAAQGQRrDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRlQLQVSVKDLFSCRTL 82
Cdd:PRK12316  1002 APEASVAQQ-GYVAPRNALERTLAAIWQDVLGVERVGL--DDNFFELGGDSIVSIQVVSRARQA-GIQLSPRDLFQHQTI 1077

                           90
                   ....*....|...
gi 1784558426   83 RRLheHLVARCEP 95
Cdd:PRK12316  1078 RSL--ALVAKAGQ 1088
PRK12316 PRK12316
peptide synthase; Provisional
 4-85 1.36e-20

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 84.62  E-value: 1.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    4 PEAAQGQRrDYELPSTELEQQLSVIWSEVLGIKAGGLSvhDDFFRLGGDSIISIQLISRIRQrLQLQVSVKDLFSCRTLR 83
Cdd:PRK12316  3541 PDAALLQQ-DYVAPVNELERRLAAIWADVLKLEQVGLT--DNFFELGGDSIISLQVVSRARQ-AGIRFTPKDLFQHQTIQ 3616


                   ..
gi 1784558426   84 RL 85
Cdd:PRK12316  3617 GL 3618
PRK12467 PRK12467
peptide synthase; Provisional
 1-83 4.10e-20

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 83.29  E-value: 4.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQRRD-YELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSC 79
Cdd:PRK12467  1010 KALPKPDASAVQAtFVAPQTELEKRLAAIWADVLKVERVGL--TDNFFELGGHSLLATQVISRVRQRLGIQVPLRTLFEH 1087


                   ....
gi 1784558426   80 RTLR 83
Cdd:PRK12467  1088 QTLA 1091
PRK12467 PRK12467
peptide synthase; Provisional
 1-85 4.99e-20

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 82.90  E-value: 4.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQRRDYELPSTELEQQLSVIWSEVLGIKAGGLSvhDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCR 80
Cdd:PRK12467  3586 KALPDPDAKGSREYVAPRSEVEQQLAAIWADVLGVEQVGVT--DNFFELGGDSLLALQVLSRIRQSLGLKLSLRDLMSAP 3663


                   ....*
gi 1784558426   81 TLRRL 85
Cdd:PRK12467  3664 TIAEL 3668
PRK05691 PRK05691
peptide synthase; Validated
 3-85 1.60e-19

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 81.37  E-value: 1.60e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    3 LPEAAQgQRRDYELPSTELEQQLSVIWSEVLGIKAGGLSvhDDFFRLGGDSIISIQLISRIRQrLQLQVSVKDLFSCRTL 82
Cdd:PRK05691  2693 APDPEL-NRQAYQAPRSELEQQLAQIWREVLNVERVGLG--DNFFELGGDSILSIQVVSRARQ-LGIHFSPRDLFQHQTV 2768


                   ...
gi 1784558426   83 RRL 85
Cdd:PRK05691  2769 QTL 2771
PRK12316 PRK12316
peptide synthase; Provisional
 1-91 3.12e-19

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 80.77  E-value: 3.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEA-AQGQRRDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSC 79
Cdd:PRK12316  5052 KALPQPdASLLQQAYVAPRSELEQQVAAIWAEVLQLERVGL--DDNFFELGGHSLLAIQVTSRIQLELGLELPLRELFQT 5129

                           90
                   ....*....|..
gi 1784558426   80 RTLRRLHEHLVA 91
Cdd:PRK12316  5130 PTLAAFVELAAA 5141
PRK05691 PRK05691
peptide synthase; Validated
 1-89 3.18e-19

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 80.60  E-value: 3.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLP--EAAQGQRRDYELPSTELEQQLSVIWSEVLgiKAGGLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFS 78
Cdd:PRK05691  4220 KALPalDIGQLQSQAYLAPRNELEQTLATIWADVL--KVERVGVHDNFFELGGHSLLATQIASRVQKALQRNVPLRAMFE 4297

                           90
                   ....*....|.
gi 1784558426   79 CRTLRRLHEHL 89
Cdd:PRK05691  4298 CSTVEELAEYI 4308
PRK05691 PRK05691
peptide synthase; Validated
 1-83 1.63e-18

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 78.67  E-value: 1.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAaQGQRRDYELPSTELEQQLSVIWSEVLGIKAGGLsvHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCR 80
Cdd:PRK05691  1620 RALPEP-VWQQREHVEPRTELQQQIAAIWREVLGLPRVGL--RDDFFALGGHSLLATQIVSRTRQACDVELPLRALFEAS 1696


                   ...
gi 1784558426   81 TLR 83
Cdd:PRK05691  1697 ELG 1699
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 17-92 1.93e-17

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 69.88  E-value: 1.93e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1784558426 17 PSTELEQQLSVIWSEVLGIKAGGLSVHDDFFR-LGGDSIISIQLISRIRQRLQLQVSVKDLFSCRTLRRLHEHLVAR 92
Cdd:COG0236    2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEdLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 23-83 1.19e-16

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 67.59  E-value: 1.19e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784558426 23 QQLSVIWSEVLGIKAGGLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCRTLR 83
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
PRK12316 PRK12316
peptide synthase; Provisional
 1-82 1.67e-15

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 69.99  E-value: 1.67e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQ-RRDYELPSTELEQQLSVIWSEVLGIKAGGLSvhDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSC 79
Cdd:PRK12316  2496 KALPKPDVSQlRQAYVAPQEGLEQRLAAIWQAVLKVEQVGLD--DHFFELGGHSLLATQVVSRVRQDLGLEVPLRILFER 2573


                   ...
gi 1784558426   80 RTL 82
Cdd:PRK12316  2574 PTL 2576
AcpA COG3433
Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites ...
 15-92 4.90e-14

Acyl carrier protein/domain [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442659 [Multi-domain]  Cd Length: 295  Bit Score: 65.16  E-value: 4.90e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1784558426  15 ELPSTELEQQLSVIWSEVLGIKAGGLSVHDDFFRLGGDSIISIQLISRIRQRlQLQVSVKDLFSCRTLRRLHEHLVAR 92
Cdd:COG3433   214 ALETALTEEELRADVAELLGVDPEEIDPDDNLFDLGLDSIRLMQLVERWRKA-GLDVSFADLAEHPTLAAWWALLAAA 290
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
1-85 1.44e-11

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 58.90  E-value: 1.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQRRDYELPSTELEQQLSVIWSEVLGIKAggLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCR 80
Cdd:PRK10252   959 KALPLPELKAQVPGRAPKTGTETIIAAAFSSLLGCDV--VDADADFFALGGHSLLAMKLAAQLSRQFARQVTPGQVMVAS 1036


                   ....*
gi 1784558426   81 TLRRL 85
Cdd:PRK10252  1037 TVAKL 1041
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 3-92 3.78e-10

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 51.48  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426   3 LPEAAQGQRRDyelpstELEQQLSVIWSEVLGIKAGG-LSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSCRT 81
Cdd:smart00823  1 LAALPPAERRR------LLLDLVREQVAAVLGHAAAEaIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPT 74

                          90
                  ....*....|.
gi 1784558426  82 LRRLHEHLVAR 92
Cdd:smart00823 75 PAALAEHLAAE 85
alpha_am_amid TIGR03443
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...
 1-83 1.16e-09

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.


Pssm-ID: 274582 [Multi-domain]  Cd Length: 1389  Bit Score: 53.53  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784558426    1 KNLPEAAQGQRRDYELPS-TELEQQLSVIWSEVLGIKAGGLSVHDDFFRLGGDSIISIQLISRIRQRLQLQVSVKDLFSC 79
Cdd:TIGR03443  828 AQLAAVAKNRSASAADEEfTETEREIRDLWLELLPNRPATISPDDSFFDLGGHSILATRMIFELRKKLNVELPLGLIFKS 907


                   ....
gi 1784558426   80 RTLR 83
Cdd:TIGR03443  908 PTIK 911
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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