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Conserved domains on  [gi|1784302000|gb|QGW96322|]
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glycosyltransferase family 2 protein [Aeromonas veronii]

Protein Classification

glycosyltransferase family A protein( domain architecture ID 10091567)

Glycosyltransferase family A (GT-A) protein is part of a diverse family of glycosyl transferases with a common GT-A type structural fold

EC:  2.4.-.-
PubMed:  34850161|12691742

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA super family cl33890
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 60-103 2.60e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG0463:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 43.92  E-value: 2.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1784302000  60 DKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEKNP 103
Cdd:COG0463    67 NRGKGAARNAGLAAARGDYIAFLDaDDQLDPEKLEELVAALEEGP 111
BcsA super family cl43359
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 18-100 1.68e-03

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


The actual alignment was detected with superfamily member COG1215:

Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 38.95  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  18 LLNLPESSDKLKIIIV--HQVDDVCHNAQHLFSHRSDVKYF-MMLDKGVTKSRNFALQQATADIILFCDDDVLYE-NFFD 93
Cdd:COG1215    51 LLAQDYPKEKLEVIVVddGSTDETAEIARELAAEYPRVRVIeRPENGGKAAALNAGLKAARGDIVVFLDADTVLDpDWLR 130


                  ....*..
gi 1784302000  94 ELIELYE 100
Cdd:COG1215   131 RLVAAFA 137
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 60-103 2.60e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 43.92  E-value: 2.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1784302000  60 DKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEKNP 103
Cdd:COG0463    67 NRGKGAARNAGLAAARGDYIAFLDaDDQLDPEKLEELVAALEEGP 111
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 61-111 6.59e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 42.11  E-value: 6.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784302000  61 KGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEKNPLISGITLN 111
Cdd:cd00761    63 QGLAAARNAGLKAARGEYILFLDaDDLLLPDWLERLVAELLADPEADAVGGP 114
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 26-104 4.60e-04

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 40.80  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  26 DKLKIIIV------HQVDDVCHNAQHlFSHrsdVKYFMMLDKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIEL 98
Cdd:PRK10073   34 TALEIIIVndgstdNSVEIAKHYAEN-YPH---VRLLHQANAGVSVARNTGLAVATGKYVAFPDaDDVVYPTMYETLMTM 109


                  ....*.
gi 1784302000  99 YEKNPL 104
Cdd:PRK10073  110 ALEDDL 115
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 26-103 5.33e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 39.69  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  26 DKLKIIIV--HQVDDVCHNAQHLFSHRSDVKYFMM-LDKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEK 101
Cdd:pfam00535  26 PNFEIIVVddGSTDGTVEIAEEYAKKDPRVRVIRLpENRGKAGARNAGLRAATGDYIAFLDaDDEVPPDWLEKLVEALEE 105


                  ..
gi 1784302000 102 NP 103
Cdd:pfam00535 106 DG 107
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 18-100 1.68e-03

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 38.95  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  18 LLNLPESSDKLKIIIV--HQVDDVCHNAQHLFSHRSDVKYF-MMLDKGVTKSRNFALQQATADIILFCDDDVLYE-NFFD 93
Cdd:COG1215    51 LLAQDYPKEKLEVIVVddGSTDETAEIARELAAEYPRVRVIeRPENGGKAAALNAGLKAARGDIVVFLDADTVLDpDWLR 130


                  ....*..
gi 1784302000  94 ELIELYE 100
Cdd:COG1215   131 RLVAAFA 137
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 60-103 2.60e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 43.92  E-value: 2.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1784302000  60 DKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEKNP 103
Cdd:COG0463    67 NRGKGAARNAGLAAARGDYIAFLDaDDQLDPEKLEELVAALEEGP 111
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 61-111 6.59e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 42.11  E-value: 6.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784302000  61 KGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEKNPLISGITLN 111
Cdd:cd00761    63 QGLAAARNAGLKAARGEYILFLDaDDLLLPDWLERLVAELLADPEADAVGGP 114
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
60-97 1.01e-04

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 42.29  E-value: 1.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1784302000  60 DKGVTKSRNFALQQATADIILFCDDD-VLYENFFDELIE 97
Cdd:COG1216    66 NLGFAAARNLGLRAAGGDYLLFLDDDtVVEPDWLERLLA 104
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 26-104 4.60e-04

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 40.80  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  26 DKLKIIIV------HQVDDVCHNAQHlFSHrsdVKYFMMLDKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIEL 98
Cdd:PRK10073   34 TALEIIIVndgstdNSVEIAKHYAEN-YPH---VRLLHQANAGVSVARNTGLAVATGKYVAFPDaDDVVYPTMYETLMTM 109


                  ....*.
gi 1784302000  99 YEKNPL 104
Cdd:PRK10073  110 ALEDDL 115
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 26-103 5.33e-04

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 39.69  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  26 DKLKIIIV--HQVDDVCHNAQHLFSHRSDVKYFMM-LDKGVTKSRNFALQQATADIILFCD-DDVLYENFFDELIELYEK 101
Cdd:pfam00535  26 PNFEIIVVddGSTDGTVEIAEEYAKKDPRVRVIRLpENRGKAGARNAGLRAATGDYIAFLDaDDEVPPDWLEKLVEALEE 105


                  ..
gi 1784302000 102 NP 103
Cdd:pfam00535 106 DG 107
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 18-100 1.68e-03

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 38.95  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784302000  18 LLNLPESSDKLKIIIV--HQVDDVCHNAQHLFSHRSDVKYF-MMLDKGVTKSRNFALQQATADIILFCDDDVLYE-NFFD 93
Cdd:COG1215    51 LLAQDYPKEKLEVIVVddGSTDETAEIARELAAEYPRVRVIeRPENGGKAAALNAGLKAARGDIVVFLDADTVLDpDWLR 130


                  ....*..
gi 1784302000  94 ELIELYE 100
Cdd:COG1215   131 RLVAAFA 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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