NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1779768875|ref|WP_155497175|]
View 

S9 family peptidase [Bifidobacterium pseudocatenulatum]

Protein Classification

S9 family peptidase( domain architecture ID 11448368)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
2-815 0e+00

Protease II [Amino acid transport and metabolism];


:

Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 904.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   2 PIAKRVPKERVFHGDTFIDEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMDGYW 81
Cdd:COG1770    12 PVAKKRPHTRTHHGDTRVDDYAWLRDREDPEVLAYLEAENAYTEAVMAPTKPLQETLFAEMKGRIKEDDSSVPYRDGGYW 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  82 YFVRTQEGQQYAVQCRVPIRGAddwdpptieigvpidGEQVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDTSGDER 161
Cdd:COG1770    92 YYSRTEEGKQYPIYCRKPASGA---------------GEEVLLDGNALAEGHDFFSLGGLSVSPDGRLLAYSVDTVGSER 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 162 YDFRIRSLETGKELPEVFEGI-GGACFTPDAQWVFYVKLDDAWRPYAVMRHRVGTPIVDDVEVYRERDERFWVGIGLSFD 240
Cdd:COG1770   157 YTLRIKDLETGEDLPDVIENTsGGLVWAADNRTLFYTRVDETLRPYQVWRHRLGTDPAEDVLVYEEKDERFFVGVGKTRS 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 241 ERNLVIGTGSKTTTEVLLLSTDDPEGEFRAFIPREQDVEYDVsfsrfEGAGERgediplAVVYHNALNPNFEIdvidmrs 320
Cdd:COG1770   237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSV-----EHAGDR------FYILTNDDAPNFKL------- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 321 heppyrlgegVRVAVGSPyGCEHGDEVEPGasempigtpysnpcNPAILqgahglgIEGISIHRHYVALQYRAESLTHIA 400
Cdd:COG1770   299 ----------VRAPVDAP-SRENWQELIPH--------------RPGVL-------LEGVDAFKDHLVVSERENGLPRIR 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 401 VMTKDAAAEDFLAgrpwkftelvphaleddwdVDESvdeineeraevwgaldqlaaaqgegsavhgvsrkamtssdgata 480
Cdd:COG1770   347 VRDLDDGEEHEIA-------------------FDEE-------------------------------------------- 363
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 481 dampgetrrLYSIGVGGNPSYDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVLGGFEPREYMERRVWVTARDGER 560
Cdd:COG1770   364 ---------AYTAGLGGNPEFDTDTLRYSYSSLTTPSSVYDYDLATGERTLLKQQEVPGGFDPADYVSERLWATARDGTK 434
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 561 IPVSLVWRRDVPACDSA-MFVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNKKHSFEDF 639
Cdd:COG1770   435 VPVSLVYRKDTKLDGSApLLLYGYGSYGISIDPSFSTSRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDF 514
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 640 VDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDALTSILDPSLPLTVTEWDEWGDPLHNAD 719
Cdd:COG1770   515 IACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELFAGVIAQVPFVDVLTTMLDPSLPLTTGEWDEWGNPLNDKE 594
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 720 VYRYMKEYTPYEN-APSDandarvavFPKIFITTSMNDTRVLYVEPMKWLARLQRAGVD---AVAKIEVEAGHGGTSGRY 795
Cdd:COG1770   595 AYDYMKSYSPYDNvKAQA--------YPAILVTTGLNDSRVQYWEPAKWVAKLRELKTDdnpLLLKTNMDAGHGGASGRF 666
                         810       820
                  ....*....|....*....|
gi 1779768875 796 KQWEEISYENAWCLGVMGIT 815
Cdd:COG1770   667 DALKEVALEYAFLLDLLGIA 686
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
2-815 0e+00

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 904.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   2 PIAKRVPKERVFHGDTFIDEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMDGYW 81
Cdd:COG1770    12 PVAKKRPHTRTHHGDTRVDDYAWLRDREDPEVLAYLEAENAYTEAVMAPTKPLQETLFAEMKGRIKEDDSSVPYRDGGYW 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  82 YFVRTQEGQQYAVQCRVPIRGAddwdpptieigvpidGEQVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDTSGDER 161
Cdd:COG1770    92 YYSRTEEGKQYPIYCRKPASGA---------------GEEVLLDGNALAEGHDFFSLGGLSVSPDGRLLAYSVDTVGSER 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 162 YDFRIRSLETGKELPEVFEGI-GGACFTPDAQWVFYVKLDDAWRPYAVMRHRVGTPIVDDVEVYRERDERFWVGIGLSFD 240
Cdd:COG1770   157 YTLRIKDLETGEDLPDVIENTsGGLVWAADNRTLFYTRVDETLRPYQVWRHRLGTDPAEDVLVYEEKDERFFVGVGKTRS 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 241 ERNLVIGTGSKTTTEVLLLSTDDPEGEFRAFIPREQDVEYDVsfsrfEGAGERgediplAVVYHNALNPNFEIdvidmrs 320
Cdd:COG1770   237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSV-----EHAGDR------FYILTNDDAPNFKL------- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 321 heppyrlgegVRVAVGSPyGCEHGDEVEPGasempigtpysnpcNPAILqgahglgIEGISIHRHYVALQYRAESLTHIA 400
Cdd:COG1770   299 ----------VRAPVDAP-SRENWQELIPH--------------RPGVL-------LEGVDAFKDHLVVSERENGLPRIR 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 401 VMTKDAAAEDFLAgrpwkftelvphaleddwdVDESvdeineeraevwgaldqlaaaqgegsavhgvsrkamtssdgata 480
Cdd:COG1770   347 VRDLDDGEEHEIA-------------------FDEE-------------------------------------------- 363
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 481 dampgetrrLYSIGVGGNPSYDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVLGGFEPREYMERRVWVTARDGER 560
Cdd:COG1770   364 ---------AYTAGLGGNPEFDTDTLRYSYSSLTTPSSVYDYDLATGERTLLKQQEVPGGFDPADYVSERLWATARDGTK 434
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 561 IPVSLVWRRDVPACDSA-MFVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNKKHSFEDF 639
Cdd:COG1770   435 VPVSLVYRKDTKLDGSApLLLYGYGSYGISIDPSFSTSRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDF 514
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 640 VDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDALTSILDPSLPLTVTEWDEWGDPLHNAD 719
Cdd:COG1770   515 IACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELFAGVIAQVPFVDVLTTMLDPSLPLTTGEWDEWGNPLNDKE 594
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 720 VYRYMKEYTPYEN-APSDandarvavFPKIFITTSMNDTRVLYVEPMKWLARLQRAGVD---AVAKIEVEAGHGGTSGRY 795
Cdd:COG1770   595 AYDYMKSYSPYDNvKAQA--------YPAILVTTGLNDSRVQYWEPAKWVAKLRELKTDdnpLLLKTNMDAGHGGASGRF 666
                         810       820
                  ....*....|....*....|
gi 1779768875 796 KQWEEISYENAWCLGVMGIT 815
Cdd:COG1770   667 DALKEVALEYAFLLDLLGIA 686
PRK10115 PRK10115
protease 2; Provisional
1-811 3.93e-135

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 417.37  E-value: 3.93e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   1 MPIAKRVPKERVFHGDTFIDEYEWLRD--KESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMD 78
Cdd:PRK10115    2 LPKAARIPHAMTLHGDTRIDNYYWLRDdtRSQPEVLDYLHQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  79 GYWYFVRTQEGQQYAVQCRVPIRGA--DDWDpptieigvpidgeqVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDT 156
Cdd:PRK10115   82 GYRYRHIYEPGCEYAIYQRQSAFSEewDEWE--------------TLLDANKRAAHSEFYTLGGMAITPDNTIMALAEDF 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 157 SGDERYDFRIRSLETGKELPEVFEGIGGA-CFTPDAQWVFYV-KLDDAWRPYAVMRHRVGTPIVDDVEVYRERDERFWVG 234
Cdd:PRK10115  148 LSRRQYGIRFRNLETGNWYPELLDNVEPSfVWANDSWTFYYVrKHPVTLLPYQVWRHTIGTPASQDELVYEEKDDTFYVS 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 235 IGLSFDERNLVIGTGSKTTTEVLLLSTDDPEGEFRAFIPREQDVEYdvSFSRFEGAgergediplAVVYHNALNPNFEID 314
Cdd:PRK10115  228 LHKTTSKHYVVIHLASATTSEVLLLDAELADAEPFVFLPRRKDHEY--SLDHYQHR---------FYLRSNRHGKNFGLY 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 315 VIDMRSheppyrlgegvrvavgspygcEHGDEVepgasempigtpysnpcnpaILQGAHGLGIEGISIHRHYVALQYRAE 394
Cdd:PRK10115  297 RTRVRD---------------------EQQWEE--------------------LIPPRENIMLEGFTLFTDWLVVEERQR 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 395 SLThiavmtkdaaaedflagrpwkftelvphaleddwdvdeSVDEINEERAEVWG-ALDQLAaaqgegsavhgvsrkamt 473
Cdd:PRK10115  336 GLT--------------------------------------SLRQINRKTREVIGiAFDDPA------------------ 359
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 474 ssdgatadampgetrrlYSIGVGGNPSYDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVlGGFEPREYMERRVWV 553
Cdd:PRK10115  360 -----------------YVTWIAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVLKQTEV-PGFDAANYRSEHLWI 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 554 TARDGERIPVSLVWRRD-VPACDSAMFVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNK 632
Cdd:PRK10115  422 TARDGVEVPVSLVYHRKhFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLKK 501
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 633 KHSFEDFVDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDALTSILDPSLPLTVTEWDEWG 712
Cdd:PRK10115  502 KNTFNDYLDACDALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWG 581
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 713 DPlHNADVYRYMKEYTPYENAPSDAndarvavFPKIFITTSMNDTRVLYVEPMKWLARLQRAGVD---AVAKIEVEAGHG 789
Cdd:PRK10115  582 NP-QDPQYYEYMKSYSPYDNVTAQA-------YPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDdhlLLLCTDMDSGHG 653
                         810       820
                  ....*....|....*....|..
gi 1779768875 790 GTSGRYKQWEEISYENAWCLGV 811
Cdd:PRK10115  654 GKSGRFKSYEGVAMEYAFLIAL 675
Peptidase_S9_N pfam02897
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
2-282 1.27e-70

Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.


Pssm-ID: 397164 [Multi-domain]  Cd Length: 414  Bit Score: 238.36  E-value: 1.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   2 PIAKRVPKERVFHGDTFIDEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMDGYW 81
Cdd:pfam02897   2 PTARDEHAVDEYHGDVVSDPYRWLEDDDSPETEAWVEAENKYTEDFLAQLPRLREKIKEELTALINYDDISAPFRKGGYY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  82 YFVRTQEGQQYAVQCRVPiRGADDWDPptieigvpidgEQVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDTSGDER 161
Cdd:pfam02897  82 YYFRNDGGKNQSVLYRQD-ALPGEGKP-----------EEVFLDPNTLSEDGTFTALGGFAFSPDGRLLAYSLSLSGSDW 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 162 YDFRIRSLETGKELPEVFEGIGGACF--TPDAQWVFYVKLD------DAWRPYA--VMRHRVGTPIVDDVEVYRERDERF 231
Cdd:pfam02897 150 YTIRFRDVETGEDLPDVLEGVKFSGIvwAPDGKGFFYTRYDkpdersDTGTNLNqkVWRHRLGTPQSQDVLVFEFPKDPL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1779768875 232 W-VGIGLSFDERNLVIGTGSKT-TTEVLLLSTDDPEGEFRAFIPREQDVEYDV 282
Cdd:pfam02897 230 WsLGAERSEDGKYLFISSASGTdTNELYYLDLTKETGDTLKLVDGRFDGEYDV 282
 
Name Accession Description Interval E-value
PtrB COG1770
Protease II [Amino acid transport and metabolism];
2-815 0e+00

Protease II [Amino acid transport and metabolism];


Pssm-ID: 441376 [Multi-domain]  Cd Length: 686  Bit Score: 904.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   2 PIAKRVPKERVFHGDTFIDEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMDGYW 81
Cdd:COG1770    12 PVAKKRPHTRTHHGDTRVDDYAWLRDREDPEVLAYLEAENAYTEAVMAPTKPLQETLFAEMKGRIKEDDSSVPYRDGGYW 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  82 YFVRTQEGQQYAVQCRVPIRGAddwdpptieigvpidGEQVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDTSGDER 161
Cdd:COG1770    92 YYSRTEEGKQYPIYCRKPASGA---------------GEEVLLDGNALAEGHDFFSLGGLSVSPDGRLLAYSVDTVGSER 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 162 YDFRIRSLETGKELPEVFEGI-GGACFTPDAQWVFYVKLDDAWRPYAVMRHRVGTPIVDDVEVYRERDERFWVGIGLSFD 240
Cdd:COG1770   157 YTLRIKDLETGEDLPDVIENTsGGLVWAADNRTLFYTRVDETLRPYQVWRHRLGTDPAEDVLVYEEKDERFFVGVGKTRS 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 241 ERNLVIGTGSKTTTEVLLLSTDDPEGEFRAFIPREQDVEYDVsfsrfEGAGERgediplAVVYHNALNPNFEIdvidmrs 320
Cdd:COG1770   237 GRYIVIGSGSTTTSEVRLLDADDPTAEPRLVAPREEGVEYSV-----EHAGDR------FYILTNDDAPNFKL------- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 321 heppyrlgegVRVAVGSPyGCEHGDEVEPGasempigtpysnpcNPAILqgahglgIEGISIHRHYVALQYRAESLTHIA 400
Cdd:COG1770   299 ----------VRAPVDAP-SRENWQELIPH--------------RPGVL-------LEGVDAFKDHLVVSERENGLPRIR 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 401 VMTKDAAAEDFLAgrpwkftelvphaleddwdVDESvdeineeraevwgaldqlaaaqgegsavhgvsrkamtssdgata 480
Cdd:COG1770   347 VRDLDDGEEHEIA-------------------FDEE-------------------------------------------- 363
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 481 dampgetrrLYSIGVGGNPSYDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVLGGFEPREYMERRVWVTARDGER 560
Cdd:COG1770   364 ---------AYTAGLGGNPEFDTDTLRYSYSSLTTPSSVYDYDLATGERTLLKQQEVPGGFDPADYVSERLWATARDGTK 434
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 561 IPVSLVWRRDVPACDSA-MFVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNKKHSFEDF 639
Cdd:COG1770   435 VPVSLVYRKDTKLDGSApLLLYGYGSYGISIDPSFSTSRLSLLDRGFVYAIAHIRGGGELGRRWYEDGKLLKKKNTFTDF 514
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 640 VDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDALTSILDPSLPLTVTEWDEWGDPLHNAD 719
Cdd:COG1770   515 IACAEHLIAQGYTSPGRIVAMGGSAGGLLMGAVANMAPELFAGVIAQVPFVDVLTTMLDPSLPLTTGEWDEWGNPLNDKE 594
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 720 VYRYMKEYTPYEN-APSDandarvavFPKIFITTSMNDTRVLYVEPMKWLARLQRAGVD---AVAKIEVEAGHGGTSGRY 795
Cdd:COG1770   595 AYDYMKSYSPYDNvKAQA--------YPAILVTTGLNDSRVQYWEPAKWVAKLRELKTDdnpLLLKTNMDAGHGGASGRF 666
                         810       820
                  ....*....|....*....|
gi 1779768875 796 KQWEEISYENAWCLGVMGIT 815
Cdd:COG1770   667 DALKEVALEYAFLLDLLGIA 686
PRK10115 PRK10115
protease 2; Provisional
1-811 3.93e-135

protease 2; Provisional


Pssm-ID: 182247 [Multi-domain]  Cd Length: 686  Bit Score: 417.37  E-value: 3.93e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   1 MPIAKRVPKERVFHGDTFIDEYEWLRD--KESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMD 78
Cdd:PRK10115    2 LPKAARIPHAMTLHGDTRIDNYYWLRDdtRSQPEVLDYLHQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  79 GYWYFVRTQEGQQYAVQCRVPIRGA--DDWDpptieigvpidgeqVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDT 156
Cdd:PRK10115   82 GYRYRHIYEPGCEYAIYQRQSAFSEewDEWE--------------TLLDANKRAAHSEFYTLGGMAITPDNTIMALAEDF 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 157 SGDERYDFRIRSLETGKELPEVFEGIGGA-CFTPDAQWVFYV-KLDDAWRPYAVMRHRVGTPIVDDVEVYRERDERFWVG 234
Cdd:PRK10115  148 LSRRQYGIRFRNLETGNWYPELLDNVEPSfVWANDSWTFYYVrKHPVTLLPYQVWRHTIGTPASQDELVYEEKDDTFYVS 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 235 IGLSFDERNLVIGTGSKTTTEVLLLSTDDPEGEFRAFIPREQDVEYdvSFSRFEGAgergediplAVVYHNALNPNFEID 314
Cdd:PRK10115  228 LHKTTSKHYVVIHLASATTSEVLLLDAELADAEPFVFLPRRKDHEY--SLDHYQHR---------FYLRSNRHGKNFGLY 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 315 VIDMRSheppyrlgegvrvavgspygcEHGDEVepgasempigtpysnpcnpaILQGAHGLGIEGISIHRHYVALQYRAE 394
Cdd:PRK10115  297 RTRVRD---------------------EQQWEE--------------------LIPPRENIMLEGFTLFTDWLVVEERQR 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 395 SLThiavmtkdaaaedflagrpwkftelvphaleddwdvdeSVDEINEERAEVWG-ALDQLAaaqgegsavhgvsrkamt 473
Cdd:PRK10115  336 GLT--------------------------------------SLRQINRKTREVIGiAFDDPA------------------ 359
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 474 ssdgatadampgetrrlYSIGVGGNPSYDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVlGGFEPREYMERRVWV 553
Cdd:PRK10115  360 -----------------YVTWIAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVLKQTEV-PGFDAANYRSEHLWI 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 554 TARDGERIPVSLVWRRD-VPACDSAMFVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNK 632
Cdd:PRK10115  422 TARDGVEVPVSLVYHRKhFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLKK 501
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 633 KHSFEDFVDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDALTSILDPSLPLTVTEWDEWG 712
Cdd:PRK10115  502 KNTFNDYLDACDALLKLGYGSPSLCYGMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWG 581
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 713 DPlHNADVYRYMKEYTPYENAPSDAndarvavFPKIFITTSMNDTRVLYVEPMKWLARLQRAGVD---AVAKIEVEAGHG 789
Cdd:PRK10115  582 NP-QDPQYYEYMKSYSPYDNVTAQA-------YPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDdhlLLLCTDMDSGHG 653
                         810       820
                  ....*....|....*....|..
gi 1779768875 790 GTSGRYKQWEEISYENAWCLGV 811
Cdd:PRK10115  654 GKSGRFKSYEGVAMEYAFLIAL 675
PreP COG1505
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
20-790 2.38e-79

Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];


Pssm-ID: 441114 [Multi-domain]  Cd Length: 673  Bit Score: 269.30  E-value: 2.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  20 DEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKtLRSTLFDELKSHVQENDMSVPTRMDGYWYFVRTQEGQQYAVqcrvp 99
Cdd:COG1505    22 DPYRWLEDDDSPETLAWVKAQNAVTRAYLAAIP-RREALRARLLELLNYDRIPAPFKRGGRYYNFWNDGLQNQGV----- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 100 IRGADDWDPPtieigvpidgEQVVFDTNAEAQGHDFfRIGGMDISKDGRWMLYGTDTSGDERYDFRIRSLETGKELPEVF 179
Cdd:COG1505    96 LRVRDGLDPE----------WEVLLDPNALSEDGTW-VLGAWSLSPDGRRLAYSLSEGGSDARVVRVFDVATGEFVEDGF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 180 EGIGGAcftpDAQW----VFY--------VKLDDAWRPYAVMRHRVGTPIVDDVEVYR--ERDERFWVGIGLSFDERNLV 245
Cdd:COG1505   165 EWEKKS----GVAWldgtGFVysrygepeGSLTDSGYPRKVYYHRRGTPQSEDELVFEgpPDDPERYVGVSVSEDGRYLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 246 IgTGSKTT--TEVLLLstDDPEGEFRAfIPREQDVEYDVsfsrfegagergediplaVVYHNALnpnfeidVIDMRSHEP 323
Cdd:COG1505   241 I-SRALGFyrNELYLL--DLPDGELVP-LDLPFDADYSG------------------VVNGGWL-------YLLTRLDAP 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 324 PYRLgegVRVAVGSPyGCEHGDEVEPGASEMpigtpysnpcnpailqgahglgIEGISIHRHYVALQYraeslthiavmT 403
Cdd:COG1505   292 RGRL---VAIDLAAP-GPRNWTEFIPEAEAV----------------------LEGVSWTGGRLVLSY-----------L 334
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 404 KDAAaedflagrpwkfTELVPHALEDdwdvdesvdeinEERAEVwgaldqlaAAQGEGSaVHGVSRKAmtssdgatadam 483
Cdd:COG1505   335 DDVV------------SRVRVYDLDG------------KLVREV--------PLPGLGS-VSGFSGDD------------ 369
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 484 pgetrrlysigvggnpsyDAPRMRYSFSSYTRPGELHDIDPATGEDRLLRRATVlgGFEPREYMERRVWVTARDGERIPV 563
Cdd:COG1505   370 ------------------DGDELFYSFTSFLTPPTLYRYDLGTGESELLKKPPA--PFDASDYEVEQVFATSKDGTRVPY 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 564 SLVWRRDVPAcDSAM--FVTGYGAYEISSDPGFSVSRISMLDRGVLYAVPHIRGGGEMGRAWYEQGHLLNKKHSFEDFVD 641
Cdd:COG1505   430 FIVHKKGLKL-DGPNptLLYGYGGFNISLTPSYSASGLAWLERGGVYAVANLRGGGEYGPAWHQAGLKENKQNVFDDFIA 508
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 642 AVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPfvdaltsILD----------PSlpltvteW-DE 710
Cdd:COG1505   509 AAEDLIARGYTSPERLAIQGGSNGGLLVGAALTQRPELFGAVVCAVP-------LLDmlryhkftagAS-------WiAE 574
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 711 WGDPlHNADVYRYMKEYTPYENAPSDANdarvavFPKIFITTSMNDTRvlyVEPM---KWLARLQRAGV---DAVAKIEV 784
Cdd:COG1505   575 YGDP-DDPEEFAYLYAYSPYHNVKAGVA------YPATLFTTADHDDR---VHPAharKFAARLQAAQAgdnPVLYREET 644

                  ....*.
gi 1779768875 785 EAGHGG 790
Cdd:COG1505   645 EGGHGA 650
Peptidase_S9_N pfam02897
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
2-282 1.27e-70

Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.


Pssm-ID: 397164 [Multi-domain]  Cd Length: 414  Bit Score: 238.36  E-value: 1.27e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875   2 PIAKRVPKERVFHGDTFIDEYEWLRDKESHDVQDYVAAQNRYCEQRMEPLKTLRSTLFDELKSHVQENDMSVPTRMDGYW 81
Cdd:pfam02897   2 PTARDEHAVDEYHGDVVSDPYRWLEDDDSPETEAWVEAENKYTEDFLAQLPRLREKIKEELTALINYDDISAPFRKGGYY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875  82 YFVRTQEGQQYAVQCRVPiRGADDWDPptieigvpidgEQVVFDTNAEAQGHDFFRIGGMDISKDGRWMLYGTDTSGDER 161
Cdd:pfam02897  82 YYFRNDGGKNQSVLYRQD-ALPGEGKP-----------EEVFLDPNTLSEDGTFTALGGFAFSPDGRLLAYSLSLSGSDW 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 162 YDFRIRSLETGKELPEVFEGIGGACF--TPDAQWVFYVKLD------DAWRPYA--VMRHRVGTPIVDDVEVYRERDERF 231
Cdd:pfam02897 150 YTIRFRDVETGEDLPDVLEGVKFSGIvwAPDGKGFFYTRYDkpdersDTGTNLNqkVWRHRLGTPQSQDVLVFEFPKDPL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1779768875 232 W-VGIGLSFDERNLVIGTGSKT-TTEVLLLSTDDPEGEFRAFIPREQDVEYDV 282
Cdd:pfam02897 230 WsLGAERSEDGKYLFISSASGTdTNELYYLDLTKETGDTLKLVDGRFDGEYDV 282
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
592-815 1.50e-60

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 204.00  E-value: 1.50e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 592 PGFSvSRISML-DRGVLYAVPHIRGGGEMGRAWYEQGHLLNKKHSFEDFVDAVRALQRAGLASPARTVADGGSAGGLLMG 670
Cdd:pfam00326   1 PSFS-WNAQLLaDRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 671 AVANMAPECFAGVEADVPFVDALTSILDPSLPLTvTEWDEWGDPLHNADVYRYMKEYTPYENapsdandarVAVFPKIFI 750
Cdd:pfam00326  80 AALNQRPDLFKAAVAHVPVVDWLAYMSDTSLPFT-ERYMEWGNPWDNEEGYDYLSPYSPADN---------VKVYPPLLL 149
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1779768875 751 TTSMNDTRVLYVEPMKWLARLQRAGVDAVAKIEVEAGHGGTSGRYKQwEEISYENAWCLGVMGIT 815
Cdd:pfam00326 150 IHGLLDDRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIGKPRNKV-EEYARELAFLLEYLGGT 213
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
552-800 6.54e-14

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 71.97  E-value: 6.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 552 WVTARDGERIPVSLVWRRDVPACDSAMFVTGYGAyeiSSDPGFSVSRISMLDRGvlYAV--PHIRGGGEMGRAWYEQghl 629
Cdd:COG1506     1 TFKSADGTTLPGWLYLPADGKKYPVVVYVHGGPG---SRDDSFLPLAQALASRG--YAVlaPDYRGYGESAGDWGGD--- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 630 lnkkhSFEDFVDAVRALQRAGLASPARTVADGGSAGGLLMGAVANMAPECFAGVEADVPFVDaLTSILDPSLPLTVTewd 709
Cdd:COG1506    73 -----EVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSD-LRSYYGTTREYTER--- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779768875 710 EWGDPLHNADVYRymkEYTPYENApsdandARVAVfpKIFITTSMNDTRVLYVEPMKWLARLQRAGVDAVAKIEVEAGHG 789
Cdd:COG1506   144 LMGGPWEDPEAYA---ARSPLAYA------DKLKT--PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHG 212
                         250
                  ....*....|.
gi 1779768875 790 GTSGRYKQWEE 800
Cdd:COG1506   213 FSGAGAPDYLE 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH