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Conserved domains on  [gi|1779767177|gb|QGQ56562|]
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doublesex- and mab-3-related transcription factor DM-W, partial [Xenopus itombwensis]

Protein Classification

doublesex- and mab-3-related transcription factor family protein( domain architecture ID 10465229)

doublesex- and mab-3-related transcription factor (DMRT) family protein similar to human DMRT2, also called doublesex-like 2 protein, a transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to its early epaxial enhancer element

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 27-70 1.45e-18

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


:

Pssm-ID: 459924  Cd Length: 47  Bit Score: 70.77  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1779767177 27 KCARCRNHGYATPLKGHKRFCIWRDCQCQKCSLTAERQRIIAAQ 70
Cdd:pfam00751  4 KCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
 
Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 27-70 1.45e-18

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 70.77  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1779767177 27 KCARCRNHGYATPLKGHKRFCIWRDCQCQKCSLTAERQRIIAAQ 70
Cdd:pfam00751  4 KCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
24-70 2.04e-10

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 50.44  E-value: 2.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1779767177  24 RLHKCARCRNHGYATPLKGHKRFCIWRDCQCQKCSLTAERQRIIAAQ 70
Cdd:smart00301  1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQ 47
 
Name Accession Description Interval E-value
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 27-70 1.45e-18

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 70.77  E-value: 1.45e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1779767177 27 KCARCRNHGYATPLKGHKRFCIWRDCQCQKCSLTAERQRIIAAQ 70
Cdd:pfam00751  4 KCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
24-70 2.04e-10

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 50.44  E-value: 2.04e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1779767177  24 RLHKCARCRNHGYATPLKGHKRFCIWRDCQCQKCSLTAERQRIIAAQ 70
Cdd:smart00301  1 RIPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQ 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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