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Conserved domains on  [gi|1779108288|ref|WP_155161617|]
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FAD-dependent monooxygenase [Sansalvadorimonas verongulae]

Protein Classification

Rossmann-fold NAD(P)-binding domain-containing protein( domain architecture ID 229380)

Rossmann-fold NAD(P)-binding domain-containing protein may function as an oxidoreductase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 30-367 2.91e-44

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member PRK06847:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 375  Bit Score: 157.73  E-value: 2.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEA----------VSLYAQEGHAIA 99
Cdd:PRK06847    7 VLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRVYGAGITLQGNALRALRELGVLDEcleagfgfdgVDLFDPDGTLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 100 YyddigrlLCQESFQGlhPDAHPYLALSHHSLHQTMREGIDSS--HIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLI 177
Cdd:PRK06847   87 E-------LPTPRLAG--DDLPGGGGIMRPALARILADAARAAgaDVRLGTTVTAIEQDDDGVTVTFSDGTTGRYDLVVG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 178 CEGIFSpsRVRWI---ADVEPEDMGLFCWRFLTDNPmPKVTDPHLYLGQNSAFLIYPLKNGRCYCYghITDSF---QRAR 251
Cdd:PRK06847  158 ADGLYS--KVRSLvfpDEPEPEYTGQGVWRAVLPRP-AEVDRSLMYLGPTTKAGVVPLSEDLMYLF--VTEPRpdnPRIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 252 DASVnLSLLQDTFSDYSRPV-KTVIENLDSQSPLICGRMSV--MPEPvWNRSgfeRVLCLGDAAHGCGPVLQQGVAQGLE 328
Cdd:PRK06847  233 PDTL-AALLRELLAPFGGPVlQELREQITDDAQVVYRPLETllVPAP-WHRG---RVVLIGDAAHATTPHLAQGAGMAIE 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1779108288 329 DVAVLREELERSSSVTQGITAFVARRTERVTQVCQRSNE 367
Cdd:PRK06847  308 DAIVLAEELARHDSLEAALQAYYARRWERCRMVVEASAR 346
 
Name Accession Description Interval E-value
PRK06847 PRK06847
hypothetical protein; Provisional
 30-367 2.91e-44

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 157.73  E-value: 2.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEA----------VSLYAQEGHAIA 99
Cdd:PRK06847    7 VLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRVYGAGITLQGNALRALRELGVLDEcleagfgfdgVDLFDPDGTLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 100 YyddigrlLCQESFQGlhPDAHPYLALSHHSLHQTMREGIDSS--HIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLI 177
Cdd:PRK06847   87 E-------LPTPRLAG--DDLPGGGGIMRPALARILADAARAAgaDVRLGTTVTAIEQDDDGVTVTFSDGTTGRYDLVVG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 178 CEGIFSpsRVRWI---ADVEPEDMGLFCWRFLTDNPmPKVTDPHLYLGQNSAFLIYPLKNGRCYCYghITDSF---QRAR 251
Cdd:PRK06847  158 ADGLYS--KVRSLvfpDEPEPEYTGQGVWRAVLPRP-AEVDRSLMYLGPTTKAGVVPLSEDLMYLF--VTEPRpdnPRIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 252 DASVnLSLLQDTFSDYSRPV-KTVIENLDSQSPLICGRMSV--MPEPvWNRSgfeRVLCLGDAAHGCGPVLQQGVAQGLE 328
Cdd:PRK06847  233 PDTL-AALLRELLAPFGGPVlQELREQITDDAQVVYRPLETllVPAP-WHRG---RVVLIGDAAHATTPHLAQGAGMAIE 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1779108288 329 DVAVLREELERSSSVTQGITAFVARRTERVTQVCQRSNE 367
Cdd:PRK06847  308 DAIVLAEELARHDSLEAALQAYYARRWERCRMVVEASAR 346
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 26-384 8.44e-35

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 130.83  E-value: 8.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  26 EKRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDI- 104
Cdd:COG0654     2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIALSPRSLELLRRLGLWDRLLARGAPIRGIRVRDGSd 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 105 GRLLCQESFQglHPDAHPYLALSHHSLHQTMREGIDSSH--IIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIF 182
Cdd:COG0654    82 GRVLARFDAA--ETGLPAGLVVPRADLERALLEAARALGveLRFGTEVTGLEQDADGVTVTLADGRTLRADLVVGADGAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 183 spSRVRWIADVEPEdmglfcwrfltdnpmpkvtdphlylgqnsafliyplknGRCYCYGHITDSFQRArdasvnlslLQD 262
Cdd:COG0654   160 --SAVRRLLGIGFT--------------------------------------GRDYPQRALWAGVRTE---------LRA 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 263 TFSDYSRPVKTVIEnLDSQSPLICGRMSVmpePVWNRsgfERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREEL---ER 339
Cdd:COG0654   191 RLAAAGPRLGELLE-LSPRSAFPLRRRRA---ERWRR---GRVVLLGDAAHTMHPLGGQGANLALRDAAALAWKLaaaLR 263

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1779108288 340 SSSVTQGITAFVARRTERVTQVcQRSNEKLKELSHTE----VQARNLVL 384
Cdd:COG0654   264 GRDDEAALARYERERRPRAARV-QRAADALGRLFHPDspplRLLRNAGL 311
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 30-385 1.33e-15

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 77.63  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAG-----IALPANATKQLKTLGLLEAVslyaqEGHAIAYYDDI 104
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADPGfdnrvSALSAASIRLLEKLGVWDKI-----EPARAQPIRDI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 105 gRLLCQESFQGLHPDAHPYLA------LSHHSLHQTMREGIDSSH---IIMGQAIQHLEPLDEGVSTVLENGQIFRASIL 175
Cdd:TIGR01988  77 -HVSDGGSFGALRFDADEIGLealgyvVENRVLQQALWERLQELPnvtLLCPARVVELPRHSDHVELTLDDGQQLRARLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 176 LICEGIFSPSR-------VRW-------IADVEPE-DMGLFCW-RFLTDNPMpkvtdphlylgqnsAFLiyPLKNGRC-- 237
Cdd:TIGR01988 156 VGADGANSKVRqlagiptTGWdygqsavVANVKHErPHQGTAWeRFTPTGPL--------------ALL--PLPDNRSsl 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 238 --YCYGHITDSFQRARDASVnLSLLQDTF-SDYSRPVktvienLDSQS---PLicgRMSVMPEPVwnrsgFERVLCLGDA 311
Cdd:TIGR01988 220 vwTLPPEEAERLLALSDEEF-LAELQRAFgSRLGAIT------LVGERhafPL---SLTHAKRYV-----APRLALIGDA 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 312 AHGCGPVLQQGVAQGLEDVAVLREELERssSVTQGITAFVARRTERVTQVCQRSN-------EKLKELSHTE----VQAR 380
Cdd:TIGR01988 285 AHTIHPLAGQGLNLGLRDVAALAEVLED--ARRRGEDIGSLRVLQRYERRRRFDNaamlgatDGLNRLFSNDfpplRLLR 362


                  ....*
gi 1779108288 381 NLVLK 385
Cdd:TIGR01988 363 NLGLR 367
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 30-365 1.23e-06

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 50.02  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRqweccgAGIALPANATKQLKTLGLLEAVSLyAQEGHAIAYYDDIGRLL- 108
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVERHA------TTSVLPRAHGLNQRTMELLRQAGL-EDRILAEGVPHEGMGLAf 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 109 -CQESFQGLHPDA-HPYLALshhsLHQTMREGIDSSH-------IIMGQAIQHLEPLDEGVSTVL---ENGQI--FRASI 174
Cdd:pfam01494  77 yNTRRRADLDFLTsPPRVTV----YPQTELEPILVEHaeargaqVRFGTEVLSLEQDGDGVTAVVrdrRDGEEytVRAKY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 175 LLICEGIFSPSRVRWIADVEPEDMGLFCW---RFLTDNPMPKVTDP--HLYLGQNSA--FLIYPLKN-GRCYCYGHITDS 246
Cdd:pfam01494 153 LVGCDGGRSPVRKTLGIEFEGFEGVPFGSldvLFDAPDLSDPVERAfvHYLIYAPHSrgFMVGPWRSaGRERYYVQVPWD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 247 FQRARdasvnlsllqdtfsdysRPVKTVIENLDSQSPLICGRMSVMPEPVW-------------NRSGfeRVLCLGDAAH 313
Cdd:pfam01494 233 EEVEE-----------------RPEEFTDEELKQRLRSIVGIDLALVEILWksiwgvasrvatrYRKG--RVFLAGDAAH 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 314 GCGPVLQQGVAQGLEDV--------AVLREelERSSSvtqGITAFVARRTERVTQVCQRS 365
Cdd:pfam01494 294 IHPPTGGQGLNTAIQDAfnlawklaAVLRG--QAGES---LLDTYSAERLPVAWAVVDFA 348
 
Name Accession Description Interval E-value
PRK06847 PRK06847
hypothetical protein; Provisional
 30-367 2.91e-44

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 157.73  E-value: 2.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEA----------VSLYAQEGHAIA 99
Cdd:PRK06847    7 VLIVGGGIGGLSAAIALRRAGIAVDLVEIDPEWRVYGAGITLQGNALRALRELGVLDEcleagfgfdgVDLFDPDGTLLA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 100 YyddigrlLCQESFQGlhPDAHPYLALSHHSLHQTMREGIDSS--HIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLI 177
Cdd:PRK06847   87 E-------LPTPRLAG--DDLPGGGGIMRPALARILADAARAAgaDVRLGTTVTAIEQDDDGVTVTFSDGTTGRYDLVVG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 178 CEGIFSpsRVRWI---ADVEPEDMGLFCWRFLTDNPmPKVTDPHLYLGQNSAFLIYPLKNGRCYCYghITDSF---QRAR 251
Cdd:PRK06847  158 ADGLYS--KVRSLvfpDEPEPEYTGQGVWRAVLPRP-AEVDRSLMYLGPTTKAGVVPLSEDLMYLF--VTEPRpdnPRIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 252 DASVnLSLLQDTFSDYSRPV-KTVIENLDSQSPLICGRMSV--MPEPvWNRSgfeRVLCLGDAAHGCGPVLQQGVAQGLE 328
Cdd:PRK06847  233 PDTL-AALLRELLAPFGGPVlQELREQITDDAQVVYRPLETllVPAP-WHRG---RVVLIGDAAHATTPHLAQGAGMAIE 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1779108288 329 DVAVLREELERSSSVTQGITAFVARRTERVTQVCQRSNE 367
Cdd:PRK06847  308 DAIVLAEELARHDSLEAALQAYYARRWERCRMVVEASAR 346
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 26-384 8.44e-35

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 130.83  E-value: 8.44e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  26 EKRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDI- 104
Cdd:COG0654     2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGRGIALSPRSLELLRRLGLWDRLLARGAPIRGIRVRDGSd 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 105 GRLLCQESFQglHPDAHPYLALSHHSLHQTMREGIDSSH--IIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIF 182
Cdd:COG0654    82 GRVLARFDAA--ETGLPAGLVVPRADLERALLEAARALGveLRFGTEVTGLEQDADGVTVTLADGRTLRADLVVGADGAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 183 spSRVRWIADVEPEdmglfcwrfltdnpmpkvtdphlylgqnsafliyplknGRCYCYGHITDSFQRArdasvnlslLQD 262
Cdd:COG0654   160 --SAVRRLLGIGFT--------------------------------------GRDYPQRALWAGVRTE---------LRA 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 263 TFSDYSRPVKTVIEnLDSQSPLICGRMSVmpePVWNRsgfERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREEL---ER 339
Cdd:COG0654   191 RLAAAGPRLGELLE-LSPRSAFPLRRRRA---ERWRR---GRVVLLGDAAHTMHPLGGQGANLALRDAAALAWKLaaaLR 263

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1779108288 340 SSSVTQGITAFVARRTERVTQVcQRSNEKLKELSHTE----VQARNLVL 384
Cdd:COG0654   264 GRDDEAALARYERERRPRAARV-QRAADALGRLFHPDspplRLLRNAGL 311
PRK06753 PRK06753
hypothetical protein; Provisional
 30-386 2.43e-33

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 128.27  E-value: 2.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDIGRLLC 109
Cdd:PRK06753    3 IAIIGAGIGGLTAAALLQEQGHEVKVFEKNESVKEVGAGIGIGDNVIKKLGNHDLAKGIKNAGQILSTMNLLDDKGTLLN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 110 QESFQGlHPDAhpyLALSHHSLHQTMREGIDSSHIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIFSPSRVRW 189
Cdd:PRK06753   83 KVKLKS-NTLN---VTLHRQTLIDIIKSYVKEDAIFTGKEVTKIENETDKVTIHFADGESEAFDLCIGADGIHSKVRQSV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 190 IADVEPEDMGLFCWRFLTDNPMPKVTDPHL-YLGQNSAFLIYPLKNGRCYCYGHITDSFQRARDASVNLSLLQDTFSDYS 268
Cdd:PRK06753  159 NADSKVRYQGYTCFRGLIDDIDLKLPDCAKeYWGTKGRFGIVPLLNNQAYWFITINAKERDPKYSSFGKPHLQAYFNHYP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 269 RPVKTVIENlDSQSPLICGRMSVMpEPVwNRSGFERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREELErSSSVTQGIT 348
Cdd:PRK06753  239 NEVREILDK-QSETGILHHDIYDL-KPL-KSFVYGRIVLLGDAAHATTPNMGQGAGQAMEDAIVLANCLN-AYDFEKALQ 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1779108288 349 AFVARRTERVTQVCQRSnEKLKELSHTE----VQARNLVLKN 386
Cdd:PRK06753  315 RYDKIRVKHTAKVIKRS-RKIGKIAQIEskllVALRNRVMKR 355
PRK06475 PRK06475
FAD-binding protein;
27-366 8.26e-27

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 110.68  E-value: 8.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  27 KRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDdiGR 106
Cdd:PRK06475    2 RGSPLIAGAGVAGLSAALELAARGWAVTIIEKAQELSEVGAGLQLAPNAMRHLERLGVADRLSGTGVTPKALYLMD--GR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 107 LLCQEsfqgLHPD---------AHPYLALSHHSLHQTMREGIDSSHII---MGQAI--QHLEPLDEGVSTVLENG-QIFR 171
Cdd:PRK06475   80 KARPL----LAMQlgdlarkrwHHPYIVCHRADLQSALLDACRNNPGIeikLGAEMtsQRQTGNSITATIIRTNSvETVS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 172 ASILLICEGIFspSRVRWIADVEPEDM-GLFCWRFLT--DN-------PMPKVTDPHLYLGQNSAFLIYPLKNGRCYCYG 241
Cdd:PRK06475  156 AAYLIACDGVW--SMLRAKAGFSKARFsGHIAWRTTLaaDAlpasflsAMPEHKAVSAWLGNKAHFIAYPVKGGKFFNFV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 242 HIT--DSFQRARDASVNLSLLQDTFSDYSRPVKTVIENLDSQS--PLIcgrmsvmpEPVWNR-SGFERVLCLGDAAHGCG 316
Cdd:PRK06475  234 AITggENPGEVWSKTGDKAHLKSIYADWNKPVLQILAAIDEWTywPLF--------EMADAQfVGPDRTIFLGDASHAVT 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1779108288 317 PVLQQGVAQGLEDVAVLREELErSSSVTQGITAFVARRTERVTQVCQRSN 366
Cdd:PRK06475  306 PFAAQGAAMAIEDAAALAEALD-SDDQSAGLKRFDSVRKERIAAVAKRGQ 354
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
26-389 3.28e-24

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 103.19  E-value: 3.28e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  26 EKRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYD--- 102
Cdd:PRK08163    3 KVTPVLIVGGGIGGLAAALALARQGIKVKLLEQAAEIGEIGAGIQLGPNAFSALDALGVGEAARQRAVFTDHLTMMDavd 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 103 --DIGRLLCQESFQglhpdAH---PYlALSHHS-LHQTMREG-IDSSHI--IMGQAIQHLEPLDEGVSTVLENGQIFRAS 173
Cdd:PRK08163   83 aeEVVRIPTGQAFR-----ARfgnPY-AVIHRAdIHLSLLEAvLDHPLVefRTSTHVVGIEQDGDGVTVFDQQGNRWTGD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 174 ILLICEGIFSPSRVRWIADvEPEDMGLFCWRFLTD-NPMPK---VTDPHLYLGQNSAFLIYPLKNGRCYcygHITDSFQ- 248
Cdd:PRK08163  157 ALIGCDGVKSVVRQSLVGD-APRVTGHVVYRAVIDvDDMPEdlrINAPVLWAGPHCHLVHYPLRGGEQY---NLVVTFHs 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 249 RARDA----SVNLSLLQDTFSDYSRPVKTVIENLDS-QSPLICGRmsvmpEPVwNRSGFERVLCLGDAAHgcgPVLQ--- 320
Cdd:PRK08163  233 REQEEwgvkDGSKEEVLSYFEGIHPRPRQMLDKPTSwKRWATADR-----EPV-AKWSTGRVTLLGDAAH---PMTQyma 303

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1779108288 321 QGVAQGLEDVAVLREELERSSSVTQgiTAFV----AR--RTERVtqvcQRSNEKLKELSH---TEVQARNLVLKNHGP 389
Cdd:PRK08163  304 QGACMALEDAVTLGKALEGCDGDAE--AAFAlyesVRipRTARV----VLSAREMGRIYHakgVERQVRNLLWKGRTQ 375
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 30-385 1.33e-15

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 77.63  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAG-----IALPANATKQLKTLGLLEAVslyaqEGHAIAYYDDI 104
Cdd:TIGR01988   2 IVIVGGGMVGLALALALARSGLKVALIEATPLPAPADPGfdnrvSALSAASIRLLEKLGVWDKI-----EPARAQPIRDI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 105 gRLLCQESFQGLHPDAHPYLA------LSHHSLHQTMREGIDSSH---IIMGQAIQHLEPLDEGVSTVLENGQIFRASIL 175
Cdd:TIGR01988  77 -HVSDGGSFGALRFDADEIGLealgyvVENRVLQQALWERLQELPnvtLLCPARVVELPRHSDHVELTLDDGQQLRARLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 176 LICEGIFSPSR-------VRW-------IADVEPE-DMGLFCW-RFLTDNPMpkvtdphlylgqnsAFLiyPLKNGRC-- 237
Cdd:TIGR01988 156 VGADGANSKVRqlagiptTGWdygqsavVANVKHErPHQGTAWeRFTPTGPL--------------ALL--PLPDNRSsl 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 238 --YCYGHITDSFQRARDASVnLSLLQDTF-SDYSRPVktvienLDSQS---PLicgRMSVMPEPVwnrsgFERVLCLGDA 311
Cdd:TIGR01988 220 vwTLPPEEAERLLALSDEEF-LAELQRAFgSRLGAIT------LVGERhafPL---SLTHAKRYV-----APRLALIGDA 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 312 AHGCGPVLQQGVAQGLEDVAVLREELERssSVTQGITAFVARRTERVTQVCQRSN-------EKLKELSHTE----VQAR 380
Cdd:TIGR01988 285 AHTIHPLAGQGLNLGLRDVAALAEVLED--ARRRGEDIGSLRVLQRYERRRRFDNaamlgatDGLNRLFSNDfpplRLLR 362


                  ....*
gi 1779108288 381 NLVLK 385
Cdd:TIGR01988 363 NLGLR 367
PRK07538 PRK07538
hypothetical protein; Provisional
 30-364 9.11e-14

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 72.24  E-value: 9.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDIGRLLC 109
Cdd:PRK07538    3 VLIAGGGIGGLTLALTLHQRGIEVVVFEAAPELRPLGVGINLLPHAVRELAELGLLDALDAIGIRTRELAYFNRHGQRIW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 110 QESfQGLHPD-AHPYLALS----HHSLHQTMREGIDSSHIIMGQAIQHLEPLDEGVSTVL---ENGQI--FRASILLICE 179
Cdd:PRK07538   83 SEP-RGLAAGyDWPQYSIHrgelQMLLLDAVRERLGPDAVRTGHRVVGFEQDADVTVVFLgdrAGGDLvsVRGDVLIGAD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 180 GIFspSRVRwiADVEPEDM-----GLFCWRFLTDnpMPKVTDPHLYLG---QNSAFLIYPlkngrcycyghITDSFQRAR 251
Cdd:PRK07538  162 GIH--SAVR--AQLYPDEGpprwnGVMMWRGVTE--APPFLTGRSMVMaghLDGKLVVYP-----------ISEPVDADG 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 252 DASVNL-------SLLQDTFSDYSRPVKT----------VIENLDSQSpLICGRMSV----M----PEPVWnrsGFERVL 306
Cdd:PRK07538  225 RQLINWvaevrvdDAGAPRREDWNRPGDLedflphfadwRFDWLDVPA-LIRAAEAIyeypMvdrdPLPRW---TRGRVT 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1779108288 307 CLGDAAHGCGPVLQQGVAQGLEDVAVLREELERSSSVTQGITAFVARRTERVTQVCQR 364
Cdd:PRK07538  301 LLGDAAHPMYPVGSNGASQAILDARALADALAAHGDPEAALAAYEAERRPATAQIVLA 358
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
35-237 3.81e-09

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 57.28  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  35 AGITGLAAARAFQQAGWQTTIIERRRQWE---CCGagiALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDIGRllcqe 111
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSFPGdkiCGG---GLLPRALEELEPLGLDEPLERPVRGARFYSPGGKSVE----- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 112 sfqgLHPDAHPYLALSHHSLHQTMRE-----GIDsshIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIFSPSR 186
Cdd:COG0644    73 ----LPPGRGGGYVVDRARFDRWLAEqaeeaGAE---VRTGTRVTDVLRDDGRVVVRTGDGEEIRADYVVDADGARSLLA 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 187 VRWIADVEPED-----MGLFCWRFLTDNPMPKVTDPHLYLGQNS----AFlIYPLKNGRC 237
Cdd:COG0644   146 RKLGLKRRSDEpqdyaLAIKEHWELPPLEGVDPGAVEFFFGEGApggyGW-VFPLGDGRV 204
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
28-335 5.77e-09

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 57.30  E-value: 5.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  28 RSVIISGAGITGLAAARAFQQAGWQTTII------ERRrqWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAI--- 98
Cdd:PRK07333    2 CDVVIAGGGYVGLALAVALKQAAPHLPVTvvdaapAGA--WSRDPRASAIAAAARRMLEALGVWDEIAPEAQPITDMvit 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  99 -AYYDDIGR--LLcqeSFQGLHPDAHPYLAL-SHHSLHQTMRE-----GIDsshIIMGQAIQHLEPLDEGVSTVLENGQI 169
Cdd:PRK07333   80 dSRTSDPVRpvFL---TFEGEVEPGEPFAHMvENRVLINALRKraealGID---LREATSVTDFETRDEGVTVTLSDGSV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 170 FRASILLICEGIFSPSR-------VRW-------IADVEPE--DMGLFCWRFLTDNPmpkvtdphlylgqnsaFLIYPLK 233
Cdd:PRK07333  154 LEARLLVAADGARSKLRelagiktVGWdygqsgiVCTVEHErpHGGRAEEHFLPAGP----------------FAILPLK 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 234 NGRCycyghitdSF---QRARDASVNLSLLQDTFSdysrpvktviENLDSQSPLICGRMSVMPEPvwnrSGF-------- 302
Cdd:PRK07333  218 GNRS--------SLvwtERTADAERLVALDDLVFE----------AELEQRFGHRLGELKVLGKR----RAFplgltlar 275

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1779108288 303 ----ERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLRE 335
Cdd:PRK07333  276 sfvaPRFALVGDAAHGIHPIAGQGLNLGLKDVAALAE 312
PLN02927 PLN02927
antheraxanthin epoxidase/zeaxanthin epoxidase
 9-340 1.97e-07

antheraxanthin epoxidase/zeaxanthin epoxidase


Pssm-ID: 178515 [Multi-domain]  Cd Length: 668  Bit Score: 53.18  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288   9 LIQQLNKKKEPTnvHKGEKRSVIISGAGITGLAAARAFQQAGWQTTIIER-----RRQWECCGAgIALPANATKQLKTLG 83
Cdd:PLN02927   65 LVEKEEKREAVT--EKKKKSRVLVAGGGIGGLVFALAAKKKGFDVLVFEKdlsaiRGEGKYRGP-IQIQSNALAALEAID 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  84 LleAVSLYAQEGHAIAYyDDIGRLLCQES------FQGLHPDAHPYL----ALSHHSLHQTMREGIDSSHIIMGQAIQHL 153
Cdd:PLN02927  142 I--DVAEQVMEAGCITG-DRINGLVDGISgswyvkFDTFTPAASRGLpvtrVISRMTLQQILARAVGEDVIRNESNVVDF 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 154 EPLDEGVSTVLENGQIFRASILLICEGIFSPSRVRWIADVEPEDMGLFCWRFLTDNpMPKVTDP---HLYLGQNSAFLIY 230
Cdd:PLN02927  219 EDSGDKVTVVLENGQRYEGDLLVGADGIWSKVRNNLFGRSEATYSGYTCYTGIADF-IPADIESvgyRVFLGHKQYFVSS 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 231 PLKNGRCYCYGHITDSFQRARDASVNLSLLQDTFSDYSRPVKTVIENLDSQSPLICGRMSVMPEPVWNRSgfeRVLCLGD 310
Cdd:PLN02927  298 DVGGGKMQWYAFHEEPAGGADAPNGMKKRLFEIFDGWCDNVLDLLHATEEDAILRRDIYDRSPGFTWGKG---RVTLLGD 374

                         330       340       350
                  ....*....|....*....|....*....|
gi 1779108288 311 AAHGCGPVLQQGVAQGLEDVAVLREELERS 340
Cdd:PLN02927  375 SIHAMQPNMGQGGCMAIEDSFQLALELDEA 404
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 30-365 1.23e-06

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 50.02  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRqweccgAGIALPANATKQLKTLGLLEAVSLyAQEGHAIAYYDDIGRLL- 108
Cdd:pfam01494   4 VLIVGGGPAGLMLALLLARAGVRVVLVERHA------TTSVLPRAHGLNQRTMELLRQAGL-EDRILAEGVPHEGMGLAf 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 109 -CQESFQGLHPDA-HPYLALshhsLHQTMREGIDSSH-------IIMGQAIQHLEPLDEGVSTVL---ENGQI--FRASI 174
Cdd:pfam01494  77 yNTRRRADLDFLTsPPRVTV----YPQTELEPILVEHaeargaqVRFGTEVLSLEQDGDGVTAVVrdrRDGEEytVRAKY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 175 LLICEGIFSPSRVRWIADVEPEDMGLFCW---RFLTDNPMPKVTDP--HLYLGQNSA--FLIYPLKN-GRCYCYGHITDS 246
Cdd:pfam01494 153 LVGCDGGRSPVRKTLGIEFEGFEGVPFGSldvLFDAPDLSDPVERAfvHYLIYAPHSrgFMVGPWRSaGRERYYVQVPWD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 247 FQRARdasvnlsllqdtfsdysRPVKTVIENLDSQSPLICGRMSVMPEPVW-------------NRSGfeRVLCLGDAAH 313
Cdd:pfam01494 233 EEVEE-----------------RPEEFTDEELKQRLRSIVGIDLALVEILWksiwgvasrvatrYRKG--RVFLAGDAAH 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 314 GCGPVLQQGVAQGLEDV--------AVLREelERSSSvtqGITAFVARRTERVTQVCQRS 365
Cdd:pfam01494 294 IHPPTGGQGLNTAIQDAfnlawklaAVLRG--QAGES---LLDTYSAERLPVAWAVVDFA 348
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
30-191 1.48e-06

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 49.90  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRR-QWECCG--AGI---ALPANATKQLKTLGlLEAVSLY----AQEGHAIA 99
Cdd:COG0665     5 VVVIGGGIAGLSTAYHLARRGLDVTVLERGRpGSGASGrnAGQlrpGLAALADRALVRLA-REALDLWrelaAELGIDCD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 100 Y--------------YDDIGRLLCQESFQGLH---------PDAHPYLALSH---------------HSLHQTMREGIDS 141
Cdd:COG0665    84 FrrtgvlylarteaeLAALRAEAEALRALGLPvelldaaelREREPGLGSPDyagglydpddghvdpAKLVRALARAARA 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1779108288 142 S--HIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIFSPSRVRWIA 191
Cdd:COG0665   164 AgvRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLLPMLG 215
PRK09126 PRK09126
FAD-dependent hydroxylase;
27-186 3.87e-06

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 48.40  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  27 KRSVIISGAGITGLAAARAFQQAGWQTTIIErRRQWECC------GAGIALPANATKQLKTLGLLEAVS------LYaqe 94
Cdd:PRK09126    3 HSDIVVVGAGPAGLSFARSLAGSGLKVTLIE-RQPLAALadpafdGREIALTHASREILQRLGAWDRIPedeispLR--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  95 gHAIAYYDDIGRLLCQESfQGLHPDAHPYLALSHH---SLHQTMREgIDSSHIIMGQAIQHLEPLDEGVSTVLENGQIFR 171
Cdd:PRK09126   79 -DAKVLNGRSPFALTFDA-RGRGADALGYLVPNHLirrAAYEAVSQ-QDGIELLTGTRVTAVRTDDDGAQVTLANGRRLT 155

                         170
                  ....*....|....*
gi 1779108288 172 ASILLICEGIFSPSR 186
Cdd:PRK09126  156 ARLLVAADSRFSATR 170
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
30-354 5.37e-06

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 47.97  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIER------RRQweccgagIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDD 103
Cdd:PRK07494   10 IAVIGGGPAGLAAAIALARAGASVALVAPeppyadLRT-------TALLGPSIRFLERLGLWARLAPHAAPLQSMRIVDA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 104 IGRLL------------CQESFqGLH-PDAHPYLALSHHSLHQTMREGIDSshiimgqAIQHLEPLDEGVSTVLENGQIF 170
Cdd:PRK07494   83 TGRLIrapevrfraaeiGEDAF-GYNiPNWLLNRALEARVAELPNITRFGD-------EAESVRPREDEVTVTLADGTTL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 171 RASILLICEGIFSPSRvrwiadvEPEDMGLFCWRF----LTDNpmpkVTD--PHlylgQNSA---------FLIYPLKNG 235
Cdd:PRK07494  155 SARLVVGADGRNSPVR-------EAAGIGVRTWSYpqkaLVLN----FTHsrPH----QNVStefhteggpFTQVPLPGR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 236 RCycyghitdSF---QRARDASVNLSLLQDTFSdysrpvkTVIENlDSQSplICGRMSVMPEP-VW-------NRSGFER 304
Cdd:PRK07494  220 RS--------SLvwvVRPAEAERLLALSDAALS-------AAIEE-RMQS--MLGKLTLEPGRqAWplsgqvaHRFAAGR 281

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1779108288 305 VLCLGDAAHGCGPVLQQGVAQGLEDVAVLREELERSSS---VTQGITAFVARR 354
Cdd:PRK07494  282 TALVGEAAHVFPPIGAQGLNLGLRDVATLVEIVEDRPEdpgSAAVLAAYDRAR 334
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 27-62 1.71e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 46.75  E-value: 1.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1779108288  27 KRSVIIsGAGITGLAAARAFQQAGWQTTIIERRRQW 62
Cdd:COG1232     2 KRVAVI-GGGIAGLTAAYRLAKAGHEVTVLEASDRV 36
PLN02268 PLN02268
probable polyamine oxidase
 29-59 2.51e-05

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 46.22  E-value: 2.51e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1779108288  29 SVIISGAGITGLAAARAFQQAGWQTTIIERR 59
Cdd:PLN02268    2 SVIVIGGGIAGIAAARALHDASFKVTLLESR 32
PLN03000 PLN03000
amine oxidase
 10-61 3.56e-05

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 46.17  E-value: 3.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1779108288  10 IQQLNKKKEPTnvhKGEKRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQ 61
Cdd:PLN03000  170 IAQAIKDKFPA---QSSKSSVVIVGAGLSGLAAARQLMRFGFKVTVLEGRKR 218
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
23-59 4.47e-05

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 45.30  E-value: 4.47e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1779108288  23 HKGEKRSVIISGAGITGLAAARAFQQAGWQTTIIERR 59
Cdd:COG1231     3 RRARGKDVVIVGAGLAGLAAARELRKAGLDVTVLEAR 39
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 23-58 4.73e-05

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 45.61  E-value: 4.73e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1779108288  23 HKGEKRSVIISGAGITGLAAARAFQQAGWQTTIIER 58
Cdd:PRK01747  256 GSPKARDAAIIGGGIAGAALALALARRGWQVTLYEA 291
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 30-160 7.05e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 44.31  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  30 VIIsGAGITGLAAARAFQQAGWQTTIIERRRQWeCCGAGialpANATKQL-KTLGLLEAVSLYAQEGHAIAYYddigRLL 108
Cdd:pfam01266   3 VVI-GGGIVGLSTAYELARRGLSVTLLERGDDP-GSGAS----GRNAGLIhPGLRYLEPSELARLALEALDLW----EEL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1779108288 109 CQESfqGLHPDAHP--YLALSHHSLHQTMREGIDS-------SHIIMGQAIQHLEPLDEGV 160
Cdd:pfam01266  73 EEEL--GIDCGFRRcgVLVLARDEEEEALEKLLAAlrrlgvpAELLDAEELRELEPLLPGL 131
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
27-340 1.48e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 43.70  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  27 KRSVIISGAGITGLAAARAFQQAGWQTTIIERRR--QWECCGAGI---ALPANATKQLKTLGLLEAV-SLYAQEGHAIAY 100
Cdd:PRK08773    6 RRDAVIVGGGVVGAACALALADAGLSVALVEGREppRWQADQPDLrvyAFAADNAALLDRLGVWPAVrAARAQPYRRMRV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 101 YDDIGRllcqesfQGLHPDAHPY------LALSHHSLHQTMREGIDSSHIIMG--QAIQHLEPLDEGVSTVLENGQIFRA 172
Cdd:PRK08773   86 WDAGGG-------GELGFDADTLgreqlgWIVENDLLVDRLWAALHAAGVQLHcpARVVALEQDADRVRLRLDDGRRLEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 173 SILLICEGIFSPSR-----------------VRWIADVEPEDMGlfCW-RFLTDNPMpkvtdphlylgqnsAFLiyPLKN 234
Cdd:PRK08773  159 ALAIAADGAASTLRelaglpvsrhdyaqrgvVAFVDTEHPHQAT--AWqRFLPTGPL--------------ALL--PFAD 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 235 GRCYCYGHITDSfqrarDASVNLSLLQDTFS-DYSRPVKTVIENLDSQSPlicgrmsvmpepvwnRSGF----------- 302
Cdd:PRK08773  221 GRSSIVWTLPDA-----EAERVLALDEAAFSrELTQAFAARLGEVRVASP---------------RTAFplrrqlvqqyv 280

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1779108288 303 -ERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREELERS 340
Cdd:PRK08773  281 sGRVLTLGDAAHVVHPLAGQGVNLGLRDVAALQQLVRQA 319
PRK05868 PRK05868
FAD-binding protein;
28-338 1.74e-04

FAD-binding protein;


Pssm-ID: 180297 [Multi-domain]  Cd Length: 372  Bit Score: 43.44  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  28 RSVIISGAGITGLAAARAFQQAGWQTTIIERRRQWECCGAGIALPANATKQLKTLGLLEAVSLYAQEGHAIAYYDDIGRL 107
Cdd:PRK05868    2 KTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDVRGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 108 LCQ--ESFQGLHPDAHPYLALSHHSLHQTMREGIDSS-HIIMGQAIQHLEPLDEGVSTVLENGQIFRASILLICEGIFSP 184
Cdd:PRK05868   82 LFRdtESTPTGGPVNSPDIELLRDDLVELLYGATQPSvEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHSN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 185 SRVRWIAdvePED-----MGLFCWRFLTDNPMPKVTDPHLYLGQNSAFLIYPLK-NGRCYCYGHITDSFQRA--RDASVN 256
Cdd:PRK05868  162 VRRLVFG---PEEqfvkrLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARnNTEARAALAFMDTELRIdyRDTEAQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288 257 LSLLQDTFSDYSRPVKTVIENLDSQSPLICGRMSVMPEPVWNRSgfeRVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREE 336
Cdd:PRK05868  239 FAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRG---RVALVGDAGYCCSPLSGQGTSVALLGAYILAGE 315


                  ..
gi 1779108288 337 LE 338
Cdd:PRK05868  316 LK 317
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 26-126 3.76e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 42.53  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779108288  26 EKRSVIISGAGITGLAAARAFQQAGWQTTIIERR-------RQWE-------CCGAGIALPANATKQLKTLGLLEAVSL- 90
Cdd:COG1233     2 MMYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNdtpggraRTFErpgfrfdVGPSVLTMPGVLERLFRELGLEDYLELv 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1779108288  91 -----YA---QEGHAIAYYDDIGRLlcQESFQGLHP-DAHPYLAL 126
Cdd:COG1233    82 pldpaYRvpfPDGRALDLPRDLERT--AAELERLFPgDAEAYRRF 124
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 30-59 9.39e-04

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 41.11  E-value: 9.39e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERR 59
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQR 30
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 304-354 1.20e-03

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 40.91  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1779108288 304 RVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREELERSSSVTQGITAFVARR 354
Cdd:PRK08849  280 NCVLLGDAAHTINPLAGQGVNLGFKDVDVLLAETEKQGVLNDASFARYERR 330
PRK06185 PRK06185
FAD-dependent oxidoreductase;
297-364 1.55e-03

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 40.61  E-value: 1.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1779108288 297 WNRSGFervLCLGDAAHGCGPVLQQGVAQGLED-VA---VLREELERSSSVTQGITAFVARRTE--RVTQVCQR 364
Cdd:PRK06185  281 WHRPGL---LCIGDAAHAMSPVGGVGINLAIQDaVAaanILAEPLRRGRVSDRDLAAVQRRREFptRVTQALQR 351
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 303-337 2.72e-03

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 39.75  E-value: 2.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1779108288 303 ERVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREEL 337
Cdd:PRK08850  282 ERVALVGDAAHTIHPLAGQGVNLGLLDAASLAQEI 316
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 28-60 3.87e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 39.24  E-value: 3.87e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1779108288  28 RSVIISGAGITGLAAARAFQQAGWQTTIIERRR 60
Cdd:PRK12409    2 SHIAVIGAGITGVTTAYALAQRGYQVTVFDRHR 34
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 30-62 4.00e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.07  E-value: 4.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRRQW 62
Cdd:COG3349     6 VVVVGGGLAGLAAAVELAEAGFRVTLLEARPRL 38
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 26-61 4.79e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 39.08  E-value: 4.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1779108288  26 EKRSVIISGAGITGLAAARAFQQAGWQTTIIERRRQ 61
Cdd:COG2072     5 EHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADD 40
PRK07364 PRK07364
FAD-dependent hydroxylase;
304-357 5.95e-03

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 38.46  E-value: 5.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1779108288 304 RVLCLGDAAHGCGPVLQQGVAQGLEDVAVLREELERSSSVTQGITAF-VARRTER 357
Cdd:PRK07364  295 RLALVGDAAHCCHPVGGQGLNLGIRDAAALAQVLQTAHQRGEDIGSLaVLKRYER 349
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 30-60 7.66e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 38.14  E-value: 7.66e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1779108288  30 VIISGAGITGLAAARAFQQAGWQTTIIERRR 60
Cdd:COG1249     6 LVVIGAGPGGYVAAIRAAQLGLKVALVEKGR 36
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 27-83 7.75e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 38.14  E-value: 7.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1779108288  27 KRSVIIsGAGITGLAAARAFQQAGWQTTIIERRrqweccgagiALPANATKQLKTLG 83
Cdd:COG0771     5 KKVLVL-GLGKSGLAAARLLAKLGAEVTVSDDR----------PAPELAAAELEAPG 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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