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Conserved domains on  [gi|1779080154|ref|WP_155137181|]
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lipopolysaccharide transport periplasmic protein LptA [Alcanivorax sp. VBW004]

Protein Classification

LptA/OstA family protein( domain architecture ID 10788265)

LptA/OstA family protein similar to lipopolysaccharide ABC transporter substrate-binding protein LptA that plays a role in the delivery of lipopolysaccharide to the outer leaflet of the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
25-166 7.54e-32

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 113.09  E-value: 7.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  25 QAAPMEGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLF-TKNGDLVRVEATGSPV---RMEEGEGLNAHA 100
Cdd:COG1934    18 QKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYyDKAGGIERIEATGNVTfrqKRDGGQEVEATA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1779080154 101 ENLVYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDA-SSEGDQRVRLVIPAENQTNATRT 166
Cdd:COG1934    98 DRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAeGGGGGGRVRAVLQPKQKKDKKPA 164
 
Name Accession Description Interval E-value
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
25-166 7.54e-32

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 113.09  E-value: 7.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  25 QAAPMEGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLF-TKNGDLVRVEATGSPV---RMEEGEGLNAHA 100
Cdd:COG1934    18 QKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYyDKAGGIERIEATGNVTfrqKRDGGQEVEATA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1779080154 101 ENLVYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDA-SSEGDQRVRLVIPAENQTNATRT 166
Cdd:COG1934    98 DRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAeGGGGGGRVRAVLQPKQKKDKKPA 164
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
 30-155 3.27e-31

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 110.78  E-value: 3.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  30 EGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFT-KNGDLVRVEATGSPVR----MEEGEGLNAHAENLV 104
Cdd:TIGR03002   7 EQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRnDAGGIEKATATGKPATfrqkLDNGKEIEGQANRIE 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1779080154 105 YDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDASSEG--DQRVRLVI 155
Cdd:TIGR03002  87 YDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGgkTGRVTTII 139
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
 34-140 4.99e-20

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 81.13  E-value: 4.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  34 QVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFTKNG--DLVRVEATGSPV----RMEEGEGLNAHAENLVYDI 107
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKknGPERLEATGPATfrqkVDLVGRPIRGKADRIEYDV 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1779080154 108 NARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKR 140
Cdd:pfam03968  81 AKDIIVLTGNARLTQGGNSVRGDKITYDIKEQK 113
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
30-160 4.45e-09

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 53.60  E-value: 4.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  30 EGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFTKNGDLVR--VEATGSPV---RMEE-GEGLNAHAENL 103
Cdd:PRK10894   29 DQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKevIDGYGNPAtfyQMQDnGKPVKGHASKM 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1779080154 104 VYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDASSEGDQRVRLV-IPAENQ 160
Cdd:PRK10894  109 HYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVlVPSQLQ 166
 
Name Accession Description Interval E-value
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
25-166 7.54e-32

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 113.09  E-value: 7.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  25 QAAPMEGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLF-TKNGDLVRVEATGSPV---RMEEGEGLNAHA 100
Cdd:COG1934    18 QKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYyDKAGGIERIEATGNVTfrqKRDGGQEVEATA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1779080154 101 ENLVYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDA-SSEGDQRVRLVIPAENQTNATRT 166
Cdd:COG1934    98 DRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAeGGGGGGRVRAVLQPKQKKDKKPA 164
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
 30-155 3.27e-31

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 110.78  E-value: 3.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  30 EGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFT-KNGDLVRVEATGSPVR----MEEGEGLNAHAENLV 104
Cdd:TIGR03002   7 EQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRnDAGGIEKATATGKPATfrqkLDNGKEIEGQANRIE 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1779080154 105 YDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDASSEG--DQRVRLVI 155
Cdd:TIGR03002  87 YDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGgkTGRVTTII 139
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
 34-140 4.99e-20

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 81.13  E-value: 4.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  34 QVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFTKNG--DLVRVEATGSPV----RMEEGEGLNAHAENLVYDI 107
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKknGPERLEATGPATfrqkVDLVGRPIRGKADRIEYDV 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1779080154 108 NARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKR 140
Cdd:pfam03968  81 AKDIIVLTGNARLTQGGNSVRGDKITYDIKEQK 113
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
 24-133 1.19e-12

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 65.78  E-value: 1.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  24 VQAAPMEGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFTKNGdlvRVEATGsPVRMEEGEGLnAHAENL 103
Cdd:COG1452    12 DLAPDDDAPVLIEADSLEYDQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTG---TVTAEG-NVRLTDGGNV-LTGDEA 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1779080154 104 VYDINARTLVLTGDAYIEHQGNT-FEGAKVE 133
Cdd:COG1452    87 ELNLDTKDGFIENARYQLVDRGGrGAAERIK 117
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
30-160 4.45e-09

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 53.60  E-value: 4.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779080154  30 EGPIQVTADSGRFEQDAGSGLYRGNVELIQGKRKLFADEMRLFTKNGDLVR--VEATGSPV---RMEE-GEGLNAHAENL 103
Cdd:PRK10894   29 DQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKevIDGYGNPAtfyQMQDnGKPVKGHASKM 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1779080154 104 VYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDASSEGDQRVRLV-IPAENQ 160
Cdd:PRK10894  109 HYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVlVPSQLQ 166
PRK03761 PRK03761
LPS assembly outer membrane complex protein LptD; Provisional
 24-90 7.27e-05

LPS assembly outer membrane complex protein LptD; Provisional


Pssm-ID: 235158 [Multi-domain]  Cd Length: 778  Bit Score: 42.60  E-value: 7.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1779080154  24 VQAAPMEGPIQVTADSGRFEQdAGSGLYRGNVELIQGKRKLFADEMRLfTKNGDLVRVEatgsPVRM 90
Cdd:PRK03761   42 VTGDPNQLPVTIEADHAEANY-PDDAVYTGNVDIKQGNSRLTADEVQL-HQQENPGQAE----PVRT 102
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
 100-154 3.35e-04

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 40.74  E-value: 3.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1779080154 100 AENLVYDINARTLVLTGDAYIEHQGNTFEGAKVEYSLDSKRVDAssEGDqrVRLV 154
Cdd:COG1452    25 ADSLEYDQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTGTVTA--EGN--VRLT 75
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 61-94 6.87e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 34.62  E-value: 6.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1779080154  61 KRKLFADEMRLFTKNGDLVRVEATGSPVRMEEGE 94
Cdd:pfam08447  48 GGEPYSGEYRIRRKDGEYRWVEARARPIRDENGK 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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