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Conserved domains on  [gi|1779000844|ref|WP_155109834|]
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nitrilase-related carbon-nitrogen hydrolase [Intestinirhabdus alba]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nit2 super family cl43126
Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];
5-101 5.69e-14

Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];


The actual alignment was detected with superfamily member COG0388:

Pssm-ID: 440157 [Multi-domain]  Cd Length: 264  Bit Score: 69.12  E-value: 5.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMG--CSDTDCLQTVLP-DDPLLQPLSQAASALRLTII 81
Cdd:COG0388     3 RIALAQLNPTVGDIEANLAKIEELIREAAAQGADLVVFPELFLTGypPEDDDLLELAEPlDGPALAALAELARELGIAVV 82

                          90       100
                  ....*....|....*....|.
gi 1779000844  82 AGLQVRHED-SLVKSIAVFTP 101
Cdd:COG0388    83 VGLPERDEGgRLYNTALVIDP 103
 
Name Accession Description Interval E-value
Nit2 COG0388
Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];
5-101 5.69e-14

Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];


Pssm-ID: 440157 [Multi-domain]  Cd Length: 264  Bit Score: 69.12  E-value: 5.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMG--CSDTDCLQTVLP-DDPLLQPLSQAASALRLTII 81
Cdd:COG0388     3 RIALAQLNPTVGDIEANLAKIEELIREAAAQGADLVVFPELFLTGypPEDDDLLELAEPlDGPALAALAELARELGIAVV 82

                          90       100
                  ....*....|....*....|.
gi 1779000844  82 AGLQVRHED-SLVKSIAVFTP 101
Cdd:COG0388    83 VGLPERDEGgRLYNTALVIDP 103
nitrilase cd07197
Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing ...
 6-102 2.90e-12

Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.


Pssm-ID: 143587 [Multi-domain]  Cd Length: 253  Bit Score: 63.88  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   6 IAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMG---CSDTDCLQTVLPDD-PLLQPLSQAASALRLTII 81
Cdd:cd07197     1 IAAVQLAPKIGDVEANLAKALRLIKEAAEQGADLIVLPELFLTGysfESAKEDLDLAEELDgPTLEALAELAKELGIYIV 80

                          90       100
                  ....*....|....*....|.
gi 1779000844  82 AGLQVRHEDSLVKSIAVFTPG 102
Cdd:cd07197    81 AGIAEKDGDKLYNTAVVIDPD 101
CN_hydrolase pfam00795
Carbon-nitrogen hydrolase; This family contains hydrolases that break carbon-nitrogen bonds. ...
 5-102 3.13e-08

Carbon-nitrogen hydrolase; This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.


Pssm-ID: 425873 [Multi-domain]  Cd Length: 257  Bit Score: 52.74  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDTDCLQT--VLPDDPLLQPLSQAASALRLTIIA 82
Cdd:pfam00795   1 RVALVQLPQGFWDLEANLQKALELIEEAARYGADLIVLPELFITGYPCWAHFLEaaEVGDGETLAGLAALARKNGIAIVI 80

                          90       100
                  ....*....|....*....|..
gi 1779000844  83 GL--QVRHEDSLVKSIAVFTPG 102
Cdd:pfam00795  81 GLieRWLTGGRLYNTAVLLDPD 102
nadE PRK02628
NAD synthetase; Reviewed
 22-92 1.93e-03

NAD synthetase; Reviewed


Pssm-ID: 235057 [Multi-domain]  Cd Length: 679  Bit Score: 38.69  E-value: 1.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1779000844  22 VAQHLHFVEAAADQQCELLVFPALSLMGCSDTDC-LQTVLPDDPL--LQPLSQAASALRLTIIAGLQVRHEDSL 92
Cdd:PRK02628   31 AARILALARRAADDGVALAVFPELSLSGYSCDDLfLQDTLLDAVEdaLATLVEASADLDPLLVVGAPLRVRHRL 104
 
Name Accession Description Interval E-value
Nit2 COG0388
Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];
5-101 5.69e-14

Omega-amidase YafV/Nit2, hydrolyzes alpha-ketoglutaramate [Energy production and conversion];


Pssm-ID: 440157 [Multi-domain]  Cd Length: 264  Bit Score: 69.12  E-value: 5.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMG--CSDTDCLQTVLP-DDPLLQPLSQAASALRLTII 81
Cdd:COG0388     3 RIALAQLNPTVGDIEANLAKIEELIREAAAQGADLVVFPELFLTGypPEDDDLLELAEPlDGPALAALAELARELGIAVV 82

                          90       100
                  ....*....|....*....|.
gi 1779000844  82 AGLQVRHED-SLVKSIAVFTP 101
Cdd:COG0388    83 VGLPERDEGgRLYNTALVIDP 103
nitrilase cd07197
Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing ...
 6-102 2.90e-12

Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.


Pssm-ID: 143587 [Multi-domain]  Cd Length: 253  Bit Score: 63.88  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   6 IAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMG---CSDTDCLQTVLPDD-PLLQPLSQAASALRLTII 81
Cdd:cd07197     1 IAAVQLAPKIGDVEANLAKALRLIKEAAEQGADLIVLPELFLTGysfESAKEDLDLAEELDgPTLEALAELAKELGIYIV 80

                          90       100
                  ....*....|....*....|.
gi 1779000844  82 AGLQVRHEDSLVKSIAVFTPG 102
Cdd:cd07197    81 AGIAEKDGDKLYNTAVVIDPD 101
nitrilase_8 cd07586
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The ...
 5-84 1.14e-09

Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143610  Cd Length: 269  Bit Score: 56.91  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDTDCLQTV--LPDDPLLQPLSQAASalRLTIIA 82
Cdd:cd07586     1 RVAIAQIDPVLGDVEENLEKHLEIIETARERGADLVVFPELSLTGYNLGDLVYEVamHADDPRLQALAEASG--GICVVF 78


                  ..
gi 1779000844  83 GL 84
Cdd:cd07586    79 GF 80
nitrilase_7 cd07585
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The ...
 5-102 5.64e-09

Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143609  Cd Length: 261  Bit Score: 54.63  E-value: 5.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDTDCLQTVL--PDDPLLQPLSQAASALRLTIIA 82
Cdd:cd07585     1 RIALVQFEARVGDKARNLAVIARWTRKAAAQGAELVCFPEMCITGYTHVRALSREAevPDGPSTQALSDLARRYGLTILA 80

                          90       100
                  ....*....|....*....|
gi 1779000844  83 GLQVRHEDSLVKSIAVFTPG 102
Cdd:cd07585    81 GLIEKAGDRPYNTYLVCLPD 100
CN_hydrolase pfam00795
Carbon-nitrogen hydrolase; This family contains hydrolases that break carbon-nitrogen bonds. ...
 5-102 3.13e-08

Carbon-nitrogen hydrolase; This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.


Pssm-ID: 425873 [Multi-domain]  Cd Length: 257  Bit Score: 52.74  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDTDCLQT--VLPDDPLLQPLSQAASALRLTIIA 82
Cdd:pfam00795   1 RVALVQLPQGFWDLEANLQKALELIEEAARYGADLIVLPELFITGYPCWAHFLEaaEVGDGETLAGLAALARKNGIAIVI 80

                          90       100
                  ....*....|....*....|..
gi 1779000844  83 GL--QVRHEDSLVKSIAVFTPG 102
Cdd:pfam00795  81 GLieRWLTGGRLYNTAVLLDPD 102
nitrilase_Rim1_like cd07574
Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an ...
 5-102 6.45e-07

Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143598  Cd Length: 280  Bit Score: 48.74  E-value: 6.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHL-HFVEAAADQQCELLVFP---ALSLMGC-----SDTDCLQTVLPD--DPLLQPLSQAA 73
Cdd:cd07574     2 RVAAAQYPLRRYASFEEFAAKVeYWVAEAAGYGADLLVFPeyfTMELLSLlpeaiDGLDEAIRALAAltPDYVALFSELA 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1779000844  74 SALRLTIIAG-LQVRHEDSLVKSIAVFTPG 102
Cdd:cd07574    82 RKYGINIIAGsMPVREDGRLYNRAYLFGPD 111
GAT_Gln-NAD-synth cd07570
Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases ...
 5-99 3.33e-06

Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Glutamine-dependent NAD synthetases are bifunctional enzymes, which have an N-terminal GAT domain and a C-terminal NAD+ synthetase domain. The GAT domain is a glutaminase (EC 3.5.1.2) which hydrolyses L-glutamine to L-glutamate and ammonia. The ammonia is used by the NAD+ synthetase domain in the ATP-dependent amidation of nicotinic acid adenine dinucleotide. Glutamine aminotransferases are categorized depending on their active site residues into different unrelated classes. This class of GAT domain belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to classes 7 and 8. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase forms a homooctamer.


Pssm-ID: 143594 [Multi-domain]  Cd Length: 261  Bit Score: 46.69  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSdtdclqtvlPDDPLLQP------------LSQA 72
Cdd:cd07570     1 RIALAQLNPTVGDLEGNAEKILEAIREAKAQGADLVVFPELSLTGYP---------PEDLLLRPdfleaaeealeeLAAA 71

                          90       100
                  ....*....|....*....|....*..
gi 1779000844  73 ASALRLTIIAGLQVRHEDSLVKSIAVF 99
Cdd:cd07570    72 TADLDIAVVVGLPLRHDGKLYNAAAVL 98
nitrilase_1_R2 cd07579
Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative ...
 5-101 5.57e-06

Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Members of this subgroup have two nitrilase domains. This is the second of those two domains. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143603  Cd Length: 279  Bit Score: 46.01  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPlKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDtDCLQTVLPDDPLLQPLSQAASALRLTIIAGL 84
Cdd:cd07579     1 RIAVAQFAP-TPDIAGNLATIDRLAAEAKATGAELVVFPELALTGLDD-PASEAESDTGPAVSALRRLARRLRLYLVAGF 78

                          90
                  ....*....|....*..
gi 1779000844  85 QVRHEDSLVKSIAVFTP 101
Cdd:cd07579    79 AEADGDGLYNSAVLVGP 95
nitrilase_2 cd07580
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The ...
 5-102 1.32e-04

Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143604  Cd Length: 268  Bit Score: 41.95  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSDTD-----CLQTVLPDDPLLQPLSQAASALRLT 79
Cdd:cd07580     1 RVACVQFDPRVGDLDANLARSIELIREAADAGANLVVLPELANTGYVFESrdeafALAEEVPDGASTRAWAELAAELGLY 80

                          90       100
                  ....*....|....*....|...
gi 1779000844  80 IIAGLQVRHEDSLVKSIAVFTPG 102
Cdd:cd07580    81 IVAGFAERDGDRLYNSAVLVGPD 103
nitrilase_6 cd07584
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The ...
 5-113 1.90e-03

Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.


Pssm-ID: 143608  Cd Length: 258  Bit Score: 38.50  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779000844   5 KIAAAQYEPLKMPLADQVAQHLHFVEAAADQQCELLVFPALSLMGCSdTDCLQTVL------PDDPLLQPLSQAASALRL 78
Cdd:cd07584     1 KVALIQMDSVLGDVKANLKKAAELCKEAAAEGADLICFPELATTGYR-PDLLGPKLwelsepIDGPTVRLFSELAKELGV 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1779000844  79 TIIAGLQVRHEDS--LVKSIAVFTPGIASPLTFPQSH 113
Cdd:cd07584    80 YIVCGFVEKGGVPgkVYNSAVVIDPEGESLGVYRKIH 116
nadE PRK02628
NAD synthetase; Reviewed
 22-92 1.93e-03

NAD synthetase; Reviewed


Pssm-ID: 235057 [Multi-domain]  Cd Length: 679  Bit Score: 38.69  E-value: 1.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1779000844  22 VAQHLHFVEAAADQQCELLVFPALSLMGCSDTDC-LQTVLPDDPL--LQPLSQAASALRLTIIAGLQVRHEDSL 92
Cdd:PRK02628   31 AARILALARRAADDGVALAVFPELSLSGYSCDDLfLQDTLLDAVEdaLATLVEASADLDPLLVVGAPLRVRHRL 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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