|
Name |
Accession |
Description |
Interval |
E-value |
| GT4_ALG2-like |
cd03805 |
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ... |
16-406 |
0e+00 |
|
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.
Pssm-ID: 340834 [Multi-domain] Cd Length: 392 Bit Score: 627.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 16 VLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFSESRE--LPVRCAGDWLPRSLGwgGR********** 93
Cdd:cd03805 3 VAFLHPDLGIGGAERLVVDAALALQSRGHEVTIYTSHHDPSHCFEETKDgtLPVRVRGDWLPRSIF--GRFHALCAYLRM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 94 ***ALYVLFLADEEFDVVVCDQVSACIPVFKLARRRKkILFYCHFPDLLLTRRDSFFKRLYRAPIDWVEEYTTGMADCIL 173
Cdd:cd03805 81 LYLALYLLLFSGEKYDVFIVDQVSACVPLLKLFRPSK-ILFYCHFPDQLLAQRKSLLKRLYRKPFDWLEEFTTGMADQIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 174 VNSRFTAAIFKETFKSLSHIDPDVLYPSLNITRFDSAIPEK-LDDLVPKGKKFLFLSINRYERKKNLTLALEALVKLRGR 252
Cdd:cd03805 160 VNSNFTAGVFKKTFPSLAKNPPEVLYPCVDTDSFDSTSEDPdPGDLIAKSNKKFFLSINRFERKKNIALAIEAFAKLKQK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 253 LTSqdWDKVHLIMAGGYDERVLENVQHYEELKKMVQ-LSDLGQYVTFLRSCSDEQKISLLRGCTCVLYTPSNEHFGIVPL 331
Cdd:cd03805 240 LPE--FENVRLVIAGGYDPRVAENVEYLEELQRLAEeLLNVEDQVLFLRSISDSQKEQLLSSALALLYTPSNEHFGIVPL 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777466523 332 EAMYLQCPVIAVNSGGPLESVVHNVTGFLCEPDPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQL 406
Cdd:cd03805 318 EAMYAGKPVIACNSGGPLETVVEGVTGFLCEPTPEAFAEAMLKLANDPDLADRMGAAGRKRVKEKFSREAFAERL 392
|
|
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
16-408 |
1.92e-45 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 160.78 E-value: 1.92e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 16 VLFLHPDL--GVGGAERLVLDAALALQARGCSVKIWTahYDPGHCFSESRELPVRCAGDWLPRSLGWGGR********** 93
Cdd:cd03801 2 ILLLSPELppPVGGAERHVRELARALAARGHDVTVLT--PADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRP--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 94 ***alyvlFLADEEFDVVVC-DQVSACIPVFKLARRRKKILFYCHFPDLLLTRRDSFFKR--LYRApidwveEYTTGMAD 170
Cdd:cd03801 77 --------LLRLRKFDVVHAhGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERrlLARA------EALLRRAD 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 171 CILVNSRFTAAIFKETFKSLSHiDPDVLYPSLNITRFDSAIPEKLDdlvPKGKKFLFLSINRYERKKNLTLALEALVKLR 250
Cdd:cd03801 143 AVIAVSEALRDELRALGGIPPE-KIVVIPNGVDLERFSPPLRRKLG---IPPDRPVLLFVGRLSPRKGVDLLLEALAKLL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 251 GRltsqdWDKVHLIMAGGYDErvlenvqHYEELKKMvqLSDLGQYVTFLRSCSDEQKISLLRGCTCVLYTPSNEHFGIVP 330
Cdd:cd03801 219 RR-----GPDVRLVIVGGDGP-------LRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVV 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777466523 331 LEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEPDPVH-FSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQLYQ 408
Cdd:cd03801 285 LEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEaLADALLRLLADPELRARLGRAARERVAERFSWERVAERLLD 363
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
223-392 |
1.81e-33 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 122.77 E-value: 1.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 223 KKFLFLSINRYERKKNLTLALEALVKLRGRLtsqdwDKVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRSC 302
Cdd:pfam00534 1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKN-----PNLKLVIAGDGEEE--------KRLKKLAEKLGLGDNVIFLGFV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 303 SDEQKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSL 381
Cdd:pfam00534 68 SDEDLPELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPnNAEALAEAIDKLLEDEEL 147
|
170
....*....|.
gi 1777466523 382 KATMGLAGRAR 392
Cdd:pfam00534 148 RERLGENARKR 158
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
16-384 |
1.42e-31 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 123.24 E-value: 1.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 16 VLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTaHYDPGHCFSESRELPVRCAGDWLPRSLGWGGR************ 95
Cdd:cd03811 2 ILFVIPSLSGGGAERVLLNLANALDKRGYDVTLVL-LRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLKAILK------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 96 *alYVLFLADEEFDVVVCDQVSACIPVFKLARRRKKILFYCH-FPDLLLTRRDSFFKRLYRAPidwveeyttgMADCILV 174
Cdd:cd03811 75 ---LKRILKRAKPDVVISFLGFATYIVAKLAAARSKVIAWIHsSLSKLYYLKKKLLLKLKLYK----------KADKIVC 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 175 NSRFTAAIFKETFKSL-SHIDpdVLYpslNITRFDSAIPE-KLDDLVPKGKKFLFLSINRYERKKNLTLALEALVKLRGR 252
Cdd:cd03811 142 VSKGIKEDLIRLGPSPpEKIE--VIY---NPIDIDRIRALaKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 253 LTsqdwdKVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRSCSDeqkI-SLLRGCTCVLYTPSNEHFGIVPL 331
Cdd:cd03811 217 YP-----DVKLVILGDGPLR--------EELEKLAKELGLAERVIFLGFQSN---PyPYLKKADLFVLSSRYEGFPNVLL 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1777466523 332 EAMYLQCPVIAVNSGGPLESVVHNVTGFLCEPDPVHFSEAMENFIHEPSLKAT 384
Cdd:cd03811 281 EAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAALAGILAALLQKKLDAA 333
|
|
| GT4_ALG11-like |
cd03806 |
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ... |
167-402 |
6.92e-29 |
|
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.
Pssm-ID: 340835 [Multi-domain] Cd Length: 419 Bit Score: 116.94 E-value: 6.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 167 GMADCILVNSRFTAAIFKETFKSlsHIDPDVLYPSLNITRFdSAIPEKlddlvPKGKKFLFLSINRYERKKNLTLALEAL 246
Cdd:cd03806 188 SFADVVMVNSTWTYNHIRQLWKR--NIKPSIVYPPCDTEEL-TKLPID-----EKTRENQILSIAQFRPEKNHPLQLRAF 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 247 VKLRGRLTSQDWDKVHLIMAGG----YDE-RVlenvqhyEELKKMVQLSDLGQYVTFLRSCSDEQKISLLRGCTCVLYTP 321
Cdd:cd03806 260 AELLKRLPESIRSNPKLVLIGScrneEDKeRV-------EALKLLAKELILEDSVEFVVDAPYEELKELLSTASIGLHTM 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 322 SNEHFGIVPLEAMYLQCPVIAVNSGGPLESVV----HNVTGFLCEpDPVHFSEAMENFIHEPSLKATMGLAGRARVKEKF 397
Cdd:cd03806 333 WNEHFGIGVVEYMAAGLIPLAHASAGPLLDIVvpwdGGPTGFLAS-TPEEYAEAIEKILTLSEEERLQRREAARSSAERF 411
|
....*
gi 1777466523 398 SPEAF 402
Cdd:cd03806 412 SDEEF 416
|
|
| GT4_sucrose_synthase |
cd03800 |
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
151-406 |
1.29e-25 |
|
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 107.33 E-value: 1.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 151 KRLYRAPIDWVEEYTTGMADCILVNS--RFTAAIFKETFKSLSHIDPD-----VLYPSLNITRFdSAIPEKLDDLVPKG- 222
Cdd:cd03800 138 KYRHLGAQDTYHPSLRITAEEQILEAadRVIASTPQEADELISLYGADpsrinVVPPGVDLERF-FPVDRAEARRARLLl 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 223 --KKFLFLSINRYERKKNLTLALEALVKLRGRLTsqdwdKVHLIMAGGYDERVLENVQhyEELKKMVQLSDLGQYVTFLR 300
Cdd:cd03800 217 ppDKPVVLALGRLDPRKGIDTLVRAFAQLPELRE-----LANLVLVGGPSDDPLSMDR--EELAELAEELGLIDRVRFPG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 301 SCSDEQKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEP 379
Cdd:cd03800 290 RVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPhDPEALAAALRRLLDDP 369
|
250 260
....*....|....*....|....*..
gi 1777466523 380 SLKATMGLAGRARVKEKFSPEAFTEQL 406
Cdd:cd03800 370 ALWQRLSRAGLERARAHYTWESVADQL 396
|
|
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
97-406 |
2.13e-25 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 106.14 E-value: 2.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 97 ALYVL--FLADEEFDVVVCDQVSACI---PVFKLARRRKKIL----FYCHFPDLLLTRRdsFFKRLYRapidwveeYTTG 167
Cdd:cd03808 69 ALFKLykLLKKEKPDIVHCHTPKPGIlgrLAARLAGVPKVIYtvhgLGFVFTEGKLLRL--LYLLLEK--------LALL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 168 MADCILVNSRFTAAIFKEtfKSLSHIDPDVLYP--SLNITRFDSAIPeklddlVPKGKKFLFLSINRYERKKNLTLALEA 245
Cdd:cd03808 139 FTDKVIFVNEDDRDLAIK--KGIIKKKKTVLIPgsGVDLDRFQYSPE------SLPSEKVVFLFVARLLKDKGIDELIEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 246 --LVKLRGrltsqdwDKVHLIMAGGYDERvLENVQHYEELkkmvQLSDLgqyVTFLRSCSDeqKISLLRGCTCVLYtPSN 323
Cdd:cd03808 211 akILKKKG-------PNVRFLLVGDGELE-NPSEILIEKL----GLEGR---IEFLGFRSD--VPELLAESDVFVL-PSY 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 324 -EHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEA 401
Cdd:cd03808 273 rEGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPPgDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEK 352
|
....*
gi 1777466523 402 FTEQL 406
Cdd:cd03808 353 VVNKL 357
|
|
| GT4_MtfB-like |
cd03809 |
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
125-406 |
2.54e-25 |
|
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.
Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 105.91 E-value: 2.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 125 LARRRKKILFYCH--FPDLLLTRRDSFFKRLYRAPIDWVEEYttgmADCILVNSRFTAA-IFKETFKSLSHIDpdVLYps 201
Cdd:cd03809 97 LLLKGCPQVVTIHdlIPLRYPEFFPKRFRLYYRLLLPISLRR----ADAIITVSEATRDdIIKFYGVPPEKIV--VIP-- 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 202 LNITRFDSaIPEKLDDLVPKG--KKFLFLSINRYERKKNLTLALEALVKLRGRltsqdWDKVHLIMAGGYDERvlenvqh 279
Cdd:cd03809 169 LGVDPSFF-PPESAAVLIAKYllPEPYFLYVGTLEPRKNHERLLKAFALLKKQ-----GGDLKLVIVGGKGWE------- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 280 YEELKKMVQLSDLGQYVTFLRSCSDEQKISLLRGCTCVLYtPS-NEHFGIVPLEAMYLQCPVIAVNSggpleSVVHNVTG 358
Cdd:cd03809 236 DEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVF-PSlYEGFGLPVLEAMACGTPVIASNI-----SVLPEVAG 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1777466523 359 ---FLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKeKFSPEAFTEQL 406
Cdd:cd03809 310 daaLYFDPlDPESIADAILRLLEDPSLREELIRKGLERAK-KFSWEKTAEKT 360
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
310-414 |
2.10e-24 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 97.37 E-value: 2.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 310 LLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLA 388
Cdd:COG0438 17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPgDPEALAEAILRLLEDPELRRRLGEA 96
|
90 100
....*....|....*....|....*.
gi 1777466523 389 GRARVKEKFSPEAFTEQLYQYVTKLL 414
Cdd:COG0438 97 ARERAEERFSWEAIAERLLALYEELL 122
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
15-406 |
8.97e-22 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 96.26 E-value: 8.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 15 SVLFLHPD--LGVGGAERLVLDAALALQARGCSVKI--WTAHYDPGHCFSESRE-------LPVRCagdwlpRSLGWGGR 83
Cdd:cd03794 1 KILLISQYypPPKGAAAARVYELAKELVRRGHEVTVltPSPNYPLGRIFAGATEtkdgirvIRVKL------GPIKKNGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 84 *************ALYVLFLADEEFDVVVC--DQVSACIPVFKLARR-RKKILFYCH--FPDLLLTRRDSFFKRLYRApI 158
Cdd:cd03794 75 IRRLLNYLSFALAALLKLLVREERPDVIIAysPPITLGLAALLLKKLrGAPFILDVRdlWPESLIALGVLKKGSLLKL-L 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 159 DWVEEYTTGMADCILVNSRFTAAIFKETFKSLSHIDpdVLYPSLNITRFDSAIPEKLDDLVPKGKKFLFL---SINRYEr 235
Cdd:cd03794 154 KKLERKLYRLADAIIVLSPGLKEYLLRKGVPKEKII--VIPNWADLEEFKPPPKDELRKKLGLDDKFVVVyagNIGKAQ- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 236 kkNLTLALEALVKLRGRltsqdwDKVHLIMAGGYDERvlenvqhyEELKKMVQLSDLgQYVTFLRSCSDEQKISLLRGCT 315
Cdd:cd03794 231 --GLETLLEAAERLKRR------PDIRFLFVGDGDEK--------ERLKELAKARGL-DNVTFLGRVPKEEVPELLSAAD 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 316 CVL--YTPSNEHFGIVP---LEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAG 389
Cdd:cd03794 294 VGLvpLKDNPANRGSSPsklFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPgDPEALADAILELLDDPELRRAMGENG 373
|
410
....*....|....*..
gi 1777466523 390 RARVKEKFSPEAFTEQL 406
Cdd:cd03794 374 RELAEEKFSREKLADRL 390
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
36-410 |
6.66e-21 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 93.50 E-value: 6.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 36 ALALQARGCSVKIWTAHYdPGHcfsESRELPVRCagdwlpRSLGWGGR*************AlYVLFLADEEFDVV-VCD 114
Cdd:cd03817 24 ARALEKRGHEVYVITPSD-PGA---EDEEEVVRY------RSFSIPIRKYHRQHIPFPFKKA-VIDRIKELGPDIIhTHT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 115 QVSACIPVFKLARRRK------------KILFYCHFPDLLL-TRRDSFFKRLYRapidwveeyttgMADCILVNSRFTaa 181
Cdd:cd03817 93 PFSLGKLGLRIARKLKipivhtyhtmyeDYLHYIPKGKLLVkAVVRKLVRRFYN------------HTDAVIAPSEKI-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 182 ifKETFKSLSHIDP-DVLYPSLNITRF-DSAIPEKLDDLVPKGKKFLFLSINRYERKKNLTLALEALVKLRGRltsqdwD 259
Cdd:cd03817 159 --KDTLREYGVKGPiEVIPNGIDLDKFeKPLNTEERRKLGLPPDEPILLYVGRLAKEKNIDFLLRAFAELKKE------P 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 260 KVHLIMAG-GYDErvlenvqhyEELKKMVQLSDLGQYVTFLRSCSDEQKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQC 338
Cdd:cd03817 231 NIKLVIVGdGPER---------EELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1777466523 339 PVIAVNSGGPLESVVHNVTGFLCEPDPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAfTEQLYQYV 410
Cdd:cd03817 302 PVVAAKDPAASELVEDGENGFLFEPNDETLAEKLLHLRENLELLRKLSKNAEISAREFAFAKS-VEKLYEEV 372
|
|
| GT4_WlbH-like |
cd03798 |
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
21-408 |
1.59e-19 |
|
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.
Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 89.36 E-value: 1.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 21 PDLGVGGAERLVLDAALALQARGCSVKIWTahydPGHCFSESRELPVRCAGDWLP-----RSLGWGGR************ 95
Cdd:cd03798 9 PNANSPGRGIFVRRQVRALSRRGVDVEVLA----PAPWGPAAARLLRKLLGEAVPprdgrRLLPLKPRLRLLAPLRAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 96 *ALYvLFLADEEFDVVVCDQVSACIPVFKLARRRKKI--LFYCHFPDLLLTRRDSFFKRLYRapidwveeYTTGMADCIL 173
Cdd:cd03798 85 AKLL-KRRRRGPPDLIHAHFAYPAGFAAALLARLYGVpyVVTEHGSDINVFPPRSLLRKLLR--------WALRRAARVI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 174 VNSRFTAAIFKETFKSLSHIDpdVLYPSLNITRFdsAIPEKLDDLVPKGkkFLFLSINRYERKKNLTLALEALVKLRGRl 253
Cdd:cd03798 156 AVSKALAEELVALGVPRDRVD--VIPNGVDPARF--QPEDRGLGLPLDA--FVILFVGRLIPRKGIDLLLEAFARLAKA- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 254 tSQDwdkVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRSCSDEQKISLLRGCTC-VLytPS-NEHFGIVPL 331
Cdd:cd03798 229 -RPD---VVLLIVGDGPLR--------EALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVfVL--PSrHEGFGLVLL 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1777466523 332 EAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPsLKATMGLAGRARVKEKFSPEAFTEQLYQ 408
Cdd:cd03798 295 EAMACGLPVVATDVGGIPEVVGDPETGLLVPPgDADALAAALRRALAEP-YLRELGEAARARVAERFSWVKAADRIAA 371
|
|
| GT4_WfcD-like |
cd03795 |
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ... |
221-403 |
1.83e-19 |
|
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340826 [Multi-domain] Cd Length: 355 Bit Score: 88.87 E-value: 1.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 221 KGKKFlFLSINRYERKKNLTLALEALVKLrgrltsqdwdKVHLIMAGGYDERvlenvqhyEELKKMVQLSdLGQYVTFLR 300
Cdd:cd03795 189 KGKKI-FLFIGRLVYYKGLDYLIEAAQYL----------NYPIVIGGEGPLK--------PDLEAQIELN-LLDNVKFLG 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 301 SCSDEQKISLLRGCTCVLYtPS---NEHFGIVPLEAMYLQCPVIAVNSGGPLESVV-HNVTGFLCEP-DPVHFSEAMENF 375
Cdd:cd03795 249 RVDDEEKVIYLHLCDVFVF-PSvlrSEAFGIVLLEAMMCGKPVISTNIGTGVPYVNnNGETGLVVPPkDPDALAEAIDKL 327
|
170 180
....*....|....*....|....*...
gi 1777466523 376 IHEPSLKATMGLAGRARVKEKFSPEAFT 403
Cdd:cd03795 328 LSDEELRESYGENAKKRFEELFTAEKMK 355
|
|
| GT4_AviGT4-like |
cd03802 |
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
197-410 |
6.03e-19 |
|
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.
Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 86.96 E-value: 6.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 197 VLYPSLNITRFDSAipeklddlVPKGKKFLFLSinRYERKKNLTLALEALVKLrgrltsqdwdKVHLIMAGGYDErvlen 276
Cdd:cd03802 152 VVHNGLDPADYRFQ--------PDPEDYLAFLG--RIAPEKGLEDAIRVARRA----------GLPLKIAGKVRD----- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 277 vQHYEElkkMVQLSDLGQYVTFLRSCSDEQKISLLRGCTCVLYTPS-NEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHN 355
Cdd:cd03802 207 -EDYFY---YLQEPLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHG 282
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1777466523 356 VTGFLCEPdpvhfSEAMENFIHE-PSLKatmGLAGRARVKEKFSPEAFTEQ---LYQYV 410
Cdd:cd03802 283 ETGFLVDS-----VEEMAEAIANiDRID---RAACRRYAEDRFSAARMADRyeaLYRKV 333
|
|
| GT4_WavL-like |
cd03819 |
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
16-390 |
7.38e-19 |
|
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 87.03 E-value: 7.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 16 VLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHyDPGHCFSESRELPVRCA-GDWLPRSLGWggr*********** 94
Cdd:cd03819 1 ILMLTPALEIGGAETYILDLARALAERGHRVLVVTAG-GPLLPRLRQIGIGLPGLkVPLLRALLGN-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 95 **ALYVLfLADEEFDVVVCdQVSACIPVFKLARRRK--KILFYCHfpdlLLTRRDSFFKRLYRAPIDWVEEyttgmadCI 172
Cdd:cd03819 66 -VRLARL-IRRERIDLIHA-HSRAPAWLGWLASRLTgvPLVTTVH----GSYLATYHPKDFALAVRARGDR-------VI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 173 LVnSRFTaaifKETFKSLSHIDPD---VLYPSLNITRFD-SAIPEKLDDLVPKGKKFLFLSINRYERKKNLTLALEALVK 248
Cdd:cd03819 132 AV-SELV----RDHLIEALGVDPErirVIPNGVDTDRFPpEAEAEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAE 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 249 LRGRLTsqdwdkVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRSCSDeqKISLLRGCTCVLYTPSNEHFGI 328
Cdd:cd03819 207 LKDEPD------FRLLVAGDGPER--------DEIRRLVERLGLRDRVTFTGFRED--VPAALAASDVVVLPSLHEEFGR 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1777466523 329 VPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGR 390
Cdd:cd03819 271 VALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPgDAEALADAIRAAKLLPEAREKLQAAAA 333
|
|
| GT4_BshA-like |
cd04962 |
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
125-414 |
4.02e-18 |
|
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 85.10 E-value: 4.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 125 LAR----RRKKILFYCHFPDLLLTRRDSFFKRLYRAPIDWVEEYTTgmadcilvNSRFTAAifkETFkslSHIDPD---- 196
Cdd:cd04962 102 LAReilgEKIPIVTTLHGTDITLVGYDPSLQPAVRFSINKSDRVTA--------VSSSLRQ---ETY---ELFDVDkdie 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 197 VLYPSLNITRF--DSAIPEKLDDLVPKGKKFLfLSINRYERKKNLTLALEALVKLRGRLtsqdwdKVHLIMAGGYDERVl 274
Cdd:cd04962 168 VIHNFIDEDVFkrKPAGALKRRLLAPPDEKVV-IHVSNFRPVKRIDDVVRVFARVRRKI------PAKLLLVGDGPERV- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 275 envqhyeELKKMVQLSDLGQYVTFLRSCSDEQKIslLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVH 354
Cdd:cd04962 240 -------PAEELARELGVEDRVLFLGKQDDVEEL--LSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKH 310
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1777466523 355 NVTGFLCEPDPVH-FSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQlYQYVTKLL 414
Cdd:cd04962 311 GETGFLSDVGDVDaMAKSALSILEDDELYNRMGRAARKRAAERFDPERIVPQ-YEAYYRRL 370
|
|
| GT4_trehalose_phosphorylase |
cd03792 |
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ... |
103-411 |
2.51e-17 |
|
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.
Pssm-ID: 340823 [Multi-domain] Cd Length: 378 Bit Score: 82.75 E-value: 2.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 103 LADEEFDVVVC-DQVSACIPVFKlARRRKKILFYCHFpDLlltrRDSFFKRLYRApIDWVEEYTtgmadcilvnSRFTAA 181
Cdd:cd03792 83 LLDGDADVVVIhDPQPALLPKIK-KKRDRKWIWRCHI-DI----STPLTEPQPRV-WDFLWNYI----------EGYDLF 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 182 IF--KETFKSLSHIDPDVLYPS------LNITRFDSAIP---EKLDDLVPKgkKFLFLSINRYERKKNLTLALEALVKLR 250
Cdd:cd03792 146 VFhpPEFVPPQVPPPKFYIPPSidplsgKNKDLSPADIRyylEKPFVIDPE--RPYILQVARFDPSKDPLGVIDAYKLFK 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 251 GRLtsqdwDKVHLIMAGGYDERVLENVQHYEELKKMVQLSDLgqyVTFLRSCSDEQKIS-LLRGCTCVLYTPSNEHFGIV 329
Cdd:cd03792 224 RRA-----EEPQLVICGHGAVDDPEGSVVYEEVMEYAGDDHD---IHVLRLPPSDQEINaLQRAATVVLQLSTREGFGLT 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 330 PLEAMYLQCPVIAVNSGG-PLEsVVHNVTGFLC---EPDPVHFseamENFIHEPSLKATMGLAGRARVKEKFSPeafTEQ 405
Cdd:cd03792 296 VSEALWKGKPVIATPAGGiPLQ-VIDGETGFLVnsvEGAAVRI----LRLLTDPELRRKMGLAAREHVRDNFLI---TGN 367
|
....*.
gi 1777466523 406 LYQYVT 411
Cdd:cd03792 368 LRAWLY 373
|
|
| GT4_ExpE7-like |
cd03823 |
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
19-406 |
4.27e-17 |
|
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).
Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 81.99 E-value: 4.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 19 LHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFSESRELPVRCAGDWLPRSLGWGGR*************AL 98
Cdd:cd03823 8 LYPPQRVGGAEISVHDLAEALVAEGHEVAVLTAGVGPPGQATVARSVVRYRRAPDETLPLALKRRGYELFETYNPGLRRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 99 YVLFLADEEFDVVV--CDQVSACIPVFKLARRRKKILFYCHfpDLLLTR-RDSFFKRLYRApidwveeyttgmadcILVN 175
Cdd:cd03823 88 LARLLEDFRPDVVHthNLSGLGASLLDAARDLGIPVVHTLH--DYWLLCpRQFLFKKGGDA---------------VLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 176 SRFTAAIFKETFKSLSHIDpdVLYPSLnitRFDSAIPEKLddlVPKGKKFLFLSINRYERKKNLTLALEALvklrGRLTS 255
Cdd:cd03823 151 SRFTANLHEANGLFSARIS--VIPNAV---EPDLAPPPRR---RPGTERLRFGYIGRLTEEKGIDLLVEAF----KRLPR 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 256 QDWdkvHLIMAGGYDErvlenvQHYEELKKMVQLSDLGQYVT-----FLrscsdeQKISllrgctcVLYTPS--NEHFGI 328
Cdd:cd03823 219 EDI---ELVIAGHGPL------SDERQIEGGRRIAFLGRVPTddikdFY------EKID-------VLVVPSiwPEPFGL 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777466523 329 VPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQL 406
Cdd:cd03823 277 VVREAIAAGLPVIASDLGGIAELIQPGVNGLLFAPgDAEDLAAAMRRLLTDPALLERLRAGAEPPRSTESQAEEYLKLY 355
|
|
| GT4-like |
cd03814 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
126-409 |
1.63e-16 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 80.42 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 126 ARRRKKILF----YCHFPDLLLTRRDSFFKRLYRAPIDWVeeytTGMADCILVNSRFTAAIFKET-FKSLSH----IDPD 196
Cdd:cd03814 103 AARRLGLPVvtsyHTDFPEYLSYYTLGPLSWLAWAYLRWF----HNPFDTTLVPSPSIARELEGHgFERVRLwprgVDTE 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 197 VLYPSlnitRFDSAIPEKLDDlvpkGKKFLFLSINRYERKKNLTLALEALVKLrgrltsQDWDKVHLIMAGGYDERvlen 276
Cdd:cd03814 179 LFHPS----RRDAALRRRLGP----PGRPLLLYVGRLAPEKNLEALLDADLPL------AASPPVRLVVVGDGPAR---- 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 277 vqhyEELKKMvqLSDlgqyVTFLRSCSDEQKISLLRGCTCVLYtPS-NEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHN 355
Cdd:cd03814 241 ----AELEAR--GPD----VIFTGFLTGEELARAYASADVFVF-PSrTETFGLVVLEAMASGLPVVAADAGGPRDIVRPG 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1777466523 356 VTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQLYQY 409
Cdd:cd03814 310 GTGALVEPgDAAAFAAALRALLEDPELRRRMAARARAEAERYSWEAFLDNLLDYY 364
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
15-405 |
1.85e-16 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 79.97 E-value: 1.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 15 SVLFLHPDLG-VGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFSEsrelpvrcagdwLPRSLGWGGR********** 93
Cdd:cd03820 1 KIAIVIPSISnAGGAERVAINLANHLAKKGYDVTIISLDSAEKPPFYE------------LDDNIKIKNLGDRKYSHFKL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 94 ***ALYVL-----FLADEEFDVVVCDQVS--ACIPVFKLArrrKKILFYCHFP---DLLLTRRDSFFKRLYRApidwvee 163
Cdd:cd03820 69 LLKYFKKVrrlrkYLKNNKPDVVISFRTSllTFLALIGLK---SKLIVWEHNNyeaYNKGLRRLLLRRLLYKR------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 164 yttgmADCILVNSRFTAAIFKETFKSlshidpdvlypslNITRFDSAIPEKLDDLVPKGKKFLFLSINRYERKKNLTLAL 243
Cdd:cd03820 139 -----ADKIVVLTEADKLKKYKQPNS-------------NVVVIPNPLSFPSEEPSTNLKSKRILAVGRLTYQKGFDLLI 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 244 EALVKLRGRLtsQDWDkvhLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLrsCSDEQKISLLRGCTCVLYTPSN 323
Cdd:cd03820 201 EAWALIAKKH--PDWK---LRIYGDGPER--------EELEKLIDKLGLEDRVKLL--GPTKNIAEEYANSSIFVLSSRY 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 324 EHFGIVPLEAMYLQCPVIAVNS-GGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVkEKFSPEA 401
Cdd:cd03820 266 EGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNgDVDALAEALLRLMEDEELRKKMGKNARKNA-ERFSIEK 344
|
....
gi 1777466523 402 FTEQ 405
Cdd:cd03820 345 IIKQ 348
|
|
| Glyco_trans_1_4 |
pfam13692 |
Glycosyl transferases group 1; |
222-377 |
2.37e-16 |
|
Glycosyl transferases group 1;
Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 75.24 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 222 GKKFLFLSiNRYERKKNLTLALEALVKLRGRLtsqdwDKVHLIMAGGYDERVLENvqhyeelkkmvQLSDLGQYVTFLRS 301
Cdd:pfam13692 1 RPVILFVG-RLHPNVKGVDYLLEAVPLLRKRD-----NDVRLVIVGDGPEEELEE-----------LAAGLEDRVIFTGF 63
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1777466523 302 CSDeqKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLEsVVHNVTGFLCEP-DPVHFSEAMENFIH 377
Cdd:pfam13692 64 VED--LAELLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPE-LVDGENGLLVPPgDPEALAEAILRLLE 137
|
|
| GT4_Bme6-like |
cd03821 |
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
26-406 |
5.08e-15 |
|
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 75.87 E-value: 5.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 26 GGAERLVLDAALALQARGCSVKIWTahYDPGHcfsesRELPVRCAGDWLPRSLGWGgR*************AL---YVLF 102
Cdd:cd03821 14 GGPVKVVLRLAAALAALGHEVTIVS--TGDGY-----ESLVVEENGRYIPPQDGFA-SIPLLRQGAGRTDFSPglpNWLR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 103 LADEEFDVV----VCDQVSAciPVFKLARRRKkiLFYCHFP----DLLLTRRDSFFKRLYRapiDWVEEYTTGMADCIlv 174
Cdd:cd03821 86 RNLREYDVVhihgVWTYTSL--AACKLARRRG--IPYVVSPhgmlDPWALQQKHWKKRIAL---HLIERRNLNNAALV-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 175 nsRFTAAIFKETFKSLSHIDPDVLYP-SLNITRFDSAIPEKLDDLVPKGKK-FLFLSinRYERKKNLTLALEALVKLrgr 252
Cdd:cd03821 157 --HFTSEQEADELRRFGLEPPIAVIPnGVDIPEFDPGLRDRRKHNGLEDRRiILFLG--RIHPKKGLDLLIRAARKL--- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 253 ltSQDWDKVHLIMAGgYDERvlenvqhyEELKKMVQLSD--LGQYVTFLRSCSDEQKISLLRGCTC-VLytPS-NEHFGI 328
Cdd:cd03821 230 --AEQGRDWHLVIAG-PDDG--------AYPAFLQLQSSlgLGDRVTFTGPLYGEAKWALYASADLfVL--PSySENFGN 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 329 VPLEAMYLQCPVIaVNSGGPLESVVHNVTGFLCEPDPVHFSEAMENFIHEPSLKATMGLAGRA--RVKEKFSPEAFTEQL 406
Cdd:cd03821 297 VVAEALACGLPVV-ITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRarQVEENFSWEAVAGQL 375
|
|
| GT4_WbaZ-like |
cd03804 |
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ... |
170-402 |
7.19e-15 |
|
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.
Pssm-ID: 340833 [Multi-domain] Cd Length: 356 Bit Score: 75.40 E-value: 7.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 170 DCILVNSRFTAAIFKETFkslsHIDPDVLYPSLNITRFDSAiPEKLDDlvpkgkkflFLSINRYERKKNLTLALEALVKL 249
Cdd:cd03804 159 DLFIANSQFVARRIKKFY----GRESTVIYPPVDTDAFAPA-ADKEDY---------YLTASRLVPYKRIDLAVEAFNEL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 250 RGRLtsqdwdkvhlIMAG-GYDErvlenvqhyEELKKMvqlsdLGQYVTFLRSCSDEQKISLLRGCTCVLYtPSNEHFGI 328
Cdd:cd03804 225 PKRL----------VVIGdGPDL---------DRLRAM-----ASPNVEFLGYQPDEVLKELLSKARAFVF-AAEEDFGI 279
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1777466523 329 VPLEAMYLQCPVIAVNSGGPLESVVHNVTGFL-CEPDPVHFSEAMENFIHEPSLKATMGLAGRArvkEKFSPEAF 402
Cdd:cd03804 280 VPVEAQACGTPVIAFGKGGALETVRPGPTGILfGEQTVESLKAAVEEFEQNFDRFKPQAIRANA---ERFSRARF 351
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
223-361 |
2.07e-14 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 72.44 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 223 KKFLFLSINRYERKKNLTLALEALVKLRgrltSQDWDKVHLIMAGGYDERVLENVQHYEELKKMVQLsdLGQYVtflrsc 302
Cdd:cd01635 109 PLADKVSVGRLVPEKGIDLLLEALALLK----ARLPDLVLVLVGGGGEREEEEALAAALGLLERVVI--IGGLV------ 176
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1777466523 303 SDEQKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLC 361
Cdd:cd01635 177 DDEVLELLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
|
|
| PLN02949 |
PLN02949 |
transferase, transferring glycosyl groups |
148-414 |
1.46e-13 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215511 [Multi-domain] Cd Length: 463 Bit Score: 72.08 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 148 SFFKRLYRAPIDWVEEYTTGMADCILVNSRFTAAIFKETFKSLSHIDpdVLYPSLNITRFdSAIP-EKLDDlvpkgkKFL 226
Cdd:PLN02949 200 STCKILYYRAFAWMYGLVGRCAHLAMVNSSWTKSHIEALWRIPERIK--RVYPPCDTSGL-QALPlERSED------PPY 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 227 FLSINRYERKKNLTLALEALVKLRGRLTSqDWDKVHLIMAGG----YDERVLENvqhyeeLKKMVQLSDLGQYVTFLRSC 302
Cdd:PLN02949 271 IISVAQFRPEKAHALQLEAFALALEKLDA-DVPRPKLQFVGScrnkEDEERLQK------LKDRAKELGLDGDVEFHKNV 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 303 SDEQKISLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGP-LESVVHNV---TGFLCEPDPvHFSEAMENFIHE 378
Cdd:PLN02949 344 SYRDLVRLLGGAVAGLHSMIDEHFGISVVEYMAAGAVPIAHNSAGPkMDIVLDEDgqqTGFLATTVE-EYADAILEVLRM 422
|
250 260 270
....*....|....*....|....*....|....*..
gi 1777466523 379 PSlKATMGLAGRARVK-EKFSPEAFTEQLYQYVTKLL 414
Cdd:PLN02949 423 RE-TERLEIAAAARKRaNRFSEQRFNEDFKDAIRPIL 458
|
|
| stp2 |
TIGR03088 |
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ... |
222-408 |
1.78e-13 |
|
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.
Pssm-ID: 132132 [Multi-domain] Cd Length: 374 Bit Score: 71.29 E-value: 1.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 222 GKKFLFLSINRYERKKNLTLALEALVKLRGRLtSQDWDKVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRS 301
Cdd:TIGR03088 192 DESVVVGTVGRLQAVKDQPTLVRAFALLVRQL-PEGAERLRLVIVGDGPAR--------GACEQMVRAAGLAHLVWLPGE 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 302 CSDEQkiSLLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPS 380
Cdd:TIGR03088 263 RDDVP--ALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVPPgDAVALARALQPYVSDPA 340
|
170 180 190
....*....|....*....|....*....|.
gi 1777466523 381 LKATMGLAGRARVKEKFSPEAFTEQ---LYQ 408
Cdd:TIGR03088 341 ARRAHGAAGRARAEQQFSINAMVAAyagLYD 371
|
|
| Glyco_transf_4 |
pfam13439 |
Glycosyltransferase Family 4; |
26-187 |
1.81e-12 |
|
Glycosyltransferase Family 4;
Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 65.25 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 26 GGAERLVLDAALALQARGCSVKIWTAHYDPGHCFSESRELPVRCAGDWLPRSLGWGGR*************alYVLFLAD 105
Cdd:pfam13439 1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVRVVRVPRVPLPLPPRLLRSLAFLRR-----------LRRLLRR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 106 EEFDVVVCDQVSACIPVFKLARRRKKI--LFYCHFPDLLLTRRDsFFKRLYRAPIDWVEEYTTGMADCILVNSRFTAAIF 183
Cdd:pfam13439 70 ERPDVVHAHSPFPLGLAALAARLRLGIplVVTYHGLFPDYKRLG-ARLSPLRRLLRRLERRLLRRADRVIAVSEAVADEL 148
|
....
gi 1777466523 184 KETF 187
Cdd:pfam13439 149 RRLY 152
|
|
| GT4_WbnK-like |
cd03807 |
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
16-407 |
1.89e-12 |
|
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 68.11 E-value: 1.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 16 VLFLHPDLGVGGAERLVLDAA--LALQARGCSVKIWTahyDPGHCFSESRELPVR--CAGDWLPRSLGwggr******** 91
Cdd:cd03807 2 VAHVITGLNVGGAETMLLRLLehMDKSRFEHVVISLT---GDGVLGEELLAAGVPvvCLGLSSGKDPG------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 92 *****ALYVL--FLADEEFDVVVCDQVSACI---PVFKLARRRKKILfychfpdlllTRRDSffkrlyrapidWVEEYTT 166
Cdd:cd03807 67 -----VLLRLakLIRKRNPDVVHTWMYHADLiggLAAKLAGGVKVIW----------SVRSS-----------NIPQRLT 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 167 GMAdcILVN------SRFTAAIFKETFKSL--SHIDPDVLYPSLN-ITRFDSAIPEKLDD-----LVPKGKKFLFLSINR 232
Cdd:cd03807 121 RLV--RKLClllskfSPATVANSSAVAEFHqeQGYAKNKIVVIYNgIDLFKLSPDDASRArarrrLGLAEDRRVIGIVGR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 233 YERKKNLTLALEALVKLRgrltsQDWDKVHLIMAGGYDERvlenvqhyEELKKMVQLSDLGQYVTFLRSCSDeqkISLLR 312
Cdd:cd03807 199 LHPVKDHSDLLRAAALLV-----ETHPDLRLLLVGRGPER--------PNLERLLLELGLEDRVHLLGERSD---VPALL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 313 GCTCVLYTPS-NEHFGIVPLEAMYLQCPVIAVNSGGPLESVVhNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGR 390
Cdd:cd03807 263 PAMDIFVLSSrTEGFPNALLEAMACGLPVVATDVGGAAELVD-DGTGFLVPAgDPQALADAIRALLEDPEKRARLGRAAR 341
|
410 420
....*....|....*....|
gi 1777466523 391 ARVKEKFSPEAFT---EQLY 407
Cdd:cd03807 342 ERIANEFSIDAMVrryETLY 361
|
|
| GT4-like |
cd05844 |
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
227-406 |
4.95e-12 |
|
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 66.71 E-value: 4.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 227 FLSINRYERKKNLTLALEALVKLRGRLTSqdwdkVHLIMAGGYDERvlenvqhyeelKKMVQLSDLGQYVTFLRSCSDEQ 306
Cdd:cd05844 192 ILFVGRLVEKKGCDVLIEAFRRLAARHPT-----ARLVIAGDGPLR-----------PALQALAAALGRVRFLGALPHAE 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 307 KISLLRGCTcVLYTPS-------NEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLC-EPDPVHFSEAMENFIHE 378
Cdd:cd05844 256 VQDWMRRAE-IFCLPSvtaasgdSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVpEGDVDALADALQALLAD 334
|
170 180
....*....|....*....|....*...
gi 1777466523 379 PSLKATMGLAGRARVKEKFSPEAFTEQL 406
Cdd:cd05844 335 RALADRMGGAARAFVCEQFDIRVQTAKL 362
|
|
| Glyco_trans_4_4 |
pfam13579 |
Glycosyl transferase 4-like domain; |
26-183 |
1.07e-10 |
|
Glycosyl transferase 4-like domain;
Pssm-ID: 433325 [Multi-domain] Cd Length: 158 Bit Score: 59.72 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 26 GGAERLVLDAALALQARGCSVKIWTAHYDPGHCFSESRELPVRCAgdWLPRSLGWGGR*************ALYVL--FL 103
Cdd:pfam13579 1 GGIGVYVLELARALAALGHEVRVVTPGGPPGRPELVGDGVRVHRL--PVPPRPSPLAD-----------LAALRRLrrLL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 104 ADEEFDVVVCDQVSACIPVfKLARRRKKILFYCHFPDLLLTRRDSFFKRLYRapidWVEEYTTGMADCILVNSRFTAAIF 183
Cdd:pfam13579 68 RAERPDVVHAHSPTAGLAA-RLARRRRGVPLVVTVHGLALDYGSGWKRRLAR----ALERRLLRRADAVVVVSEAEAELL 142
|
|
| GT4_AmsK-like |
cd03799 |
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
220-406 |
2.29e-10 |
|
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.
Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 61.70 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 220 PKGKKFLFLSINRYERKKNLTLALEALVKLRGRLTSQDWDKVhlimagGYDErvLEnvqhyEELKKMVQLSDLGQYVTFL 299
Cdd:cd03799 170 PLDGKIRILTVGRLTEKKGLEYAIEAVAKLAQKYPNIEYQII------GDGD--LK-----EQLQQLIQELNIGDCVKLL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 300 RSCSDEQKISLLRGcTCVLYTPS------NEHFGIVPL-EAMYLQCPVIAVNSGGPLESVVHNVTGFLC-EPDPVHFSEA 371
Cdd:cd03799 237 GWKPQEEIIEILDE-ADIFIAPSvtaadgDQDGPPNTLkEAMAMGLPVISTEHGGIPELVEDGVSGFLVpERDAEAIAEK 315
|
170 180 190
....*....|....*....|....*....|....*
gi 1777466523 372 MENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQL 406
Cdd:cd03799 316 LTYLIEHPAIWPEMGKAGRARVEEEYDINKLNDEL 350
|
|
| PLN00142 |
PLN00142 |
sucrose synthase |
205-413 |
3.91e-08 |
|
sucrose synthase
Pssm-ID: 215073 [Multi-domain] Cd Length: 815 Bit Score: 55.37 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 205 TRFDSAIPEKLDD----------LVPKGKKFLFlSINRYERKKNLTlaleALVKLRG---RLTsqdwDKVHLIMAGGY-D 270
Cdd:PLN00142 545 TSLHPSIEELLYSpeqndehigyLKDRKKPIIF-SMARLDRVKNLT----GLVEWYGknkRLR----ELVNLVVVGGFiD 615
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 271 ERVLENVQHYEELKKMVQLSDL----GQYvTFLRSCSDEQKISLLRGCTC---------VLYtpsnEHFGIVPLEAMYLQ 337
Cdd:PLN00142 616 PSKSKDREEIAEIKKMHSLIEKynlkGQF-RWIAAQTNRVRNGELYRYIAdtkgafvqpALY----EAFGLTVVEAMTCG 690
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 338 CPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFI----HEPSLKATMGLAGRARVKEKFSPEAFTEQL------ 406
Cdd:PLN00142 691 LPTFATCQGGPAEIIVDGVSGFHIDPyHGDEAANKIADFFekckEDPSYWNKISDAGLQRIYECYTWKIYAERLltlggv 770
|
250
....*....|
gi 1777466523 407 ---YQYVTKL 413
Cdd:PLN00142 771 ygfWKYVSKL 780
|
|
| GT4_WcaC-like |
cd03825 |
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
169-398 |
5.51e-08 |
|
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.
Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 54.26 E-value: 5.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 169 ADCILVN-SRFTAAIFKETFkSLSHIDPDVLYPSLNITRF---DSAIPEKLDDLVPKGKKFLFLSINRYERKKNLTLALE 244
Cdd:cd03825 137 KRLTIVApSRWLADMVRRSP-LLKGLPVVVIPNGIDTEIFapvDKAKARKRLGIPQDKKVILFGAESVTKPRKGFDELIE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 245 ALVKLrgrltsQDWDKVHLIMAGGYDERVLE---NVQHYEELKKMVQLSDLgqyvtflRSCSDeqkisllrgctcVLYTP 321
Cdd:cd03825 216 ALKLL------ATKDDLLLVVFGKNDPQIVIlpfDIISLGYIDDDEQLVDI-------YSAAD------------LFVHP 270
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1777466523 322 S-NEHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFS 398
Cdd:cd03825 271 SlADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPgDVQALAEAIEWLLANPKERESLGERARALAENHFD 349
|
|
| PLN02871 |
PLN02871 |
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase |
317-406 |
3.49e-07 |
|
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
Pssm-ID: 215469 [Multi-domain] Cd Length: 465 Bit Score: 52.02 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 317 VLYTPS-NEHFGIVPLEAMYLQCPVIAVNSGG-P--LESVVHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRA 391
Cdd:PLN02871 334 VFVMPSeSETLGFVVLEAMASGVPVVAARAGGiPdiIPPDQEGKTGFLYTPgDVDDCVEKLETLLADPELRERMGAAARE 413
|
90
....*....|....*
gi 1777466523 392 RVkEKFSPEAFTEQL 406
Cdd:PLN02871 414 EV-EKWDWRAATRKL 427
|
|
| GT4_WbdM_like |
cd04951 |
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ... |
198-408 |
7.48e-07 |
|
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340857 [Multi-domain] Cd Length: 360 Bit Score: 50.91 E-value: 7.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 198 LYPSLNITRFDSAIPEKL---DDLVPKGKKFLFLSINRYERKKNLTLALEALVKLrgrltSQDWDKVHLIMAGgydERVL 274
Cdd:cd04951 159 VYNGIDLNKFKKDINVRLkirNKLNLKNDEFVILNVGRLTEAKDYPNLLLAISEL-----ILSKNDFKLLIAG---DGPL 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 275 ENvqhyeELKKMVQLSDLGQYVTFLRSCSDeqkIS-LLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGPLEsVV 353
Cdd:cd04951 231 RN-----ELERLICNLNLVDRVILLGQISN---ISeYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAE-VV 301
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1777466523 354 HNVTGFLCEPDPVHFSEAM-ENFIHEPSLKATMGLAGRARVKeKFSPEAFTEQLYQ 408
Cdd:cd04951 302 GDHNYVVPVSDPQLLAEKIkEIFDMSDEERDILGNKNEYIAK-NFSINTIVNEWER 356
|
|
| GT4_GtfA-like |
cd04949 |
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ... |
223-405 |
2.19e-06 |
|
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340855 [Multi-domain] Cd Length: 328 Bit Score: 49.22 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 223 KKFLFLSINRYERKKNLTLALEALVKLRGRLTSQdwdKVHLImagGYDErvlenvqHYEELKKMVQLSDLGQYVT---FL 299
Cdd:cd04949 159 KSNKIITISRLAPEKQLDHLIEAVAKAVKKVPEI---TLDIY---GYGE-------EREKLKKLIEELHLEDNVFlkgYH 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 300 RSCSDEQKISLLrgctcVLYTPSNEHFGIVPLEAMYLQCPVIAVNSG-GPLESVVHNVTGFLCEPDPVH-FSEAMENFIH 377
Cdd:cd04949 226 SNLDQEYQDAYL-----SLLTSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLIEKNNIDaLADKIIELLN 300
|
170 180
....*....|....*....|....*...
gi 1777466523 378 EPSLKATMGLAGRArVKEKFSPEAFTEQ 405
Cdd:cd04949 301 DPEKLQQFSEESYK-IAEKYSTENVMEK 327
|
|
| GT4-like |
cd03813 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
194-405 |
1.36e-05 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 46.94 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 194 DPD---VLYPSLNITRFDSAIPEKlddlvPKGKKFLFLSINRYERKKNLTLALEAL-VKLRGRLTSQDWdkvhLImaGGY 269
Cdd:cd03813 265 DPDktrVIPNGIDIQRFAPAREER-----PEKEPPVVGLVGRVVPIKDVKTFIRAFkLVRRAMPDAEGW----LI--GPE 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 270 DErvleNVQHYEELKKMVQLSDLGQYVTFLrscsDEQKIS-LLRGCTCVLYTPSNEHFGIVPLEAMYLQCPVIAVNSGGP 348
Cdd:cd03813 334 DE----DPEYAQECKRLVASLGLENKVKFL----GFQNIKeYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSC 405
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1777466523 349 LESV-----VHNVTGFLCEP-DPVHFSEAMENFIHEPSLKATMGLAGRARVKEKFSPEAFTEQ 405
Cdd:cd03813 406 RELIygaddALGQAGLVVPPaDPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTLEGMIDS 468
|
|
| GT4_CapH-like |
cd03812 |
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
223-378 |
2.67e-03 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 39.58 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 223 KKFLFLSINRYERKKNLTLALEALVKLRGRLTSQ---------------DWDKVHLIMAGGYDERvlenvqhyEELKKMV 287
Cdd:cd03812 170 EKYKFNKEKRRKRRKLLILEDKLVLGHVGRFNEQknhsflidifeelkkKNPNVKLVLVGEGELK--------EKIKEKV 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1777466523 288 QLSDLGQYVTFLRSCSDEQKI-SLLRgctcVLYTPSN-EHFGIVPLEAMYLQCPVIAVNSGGPLESVVHNVTGFLCEPDP 365
Cdd:cd03812 242 KELGLEDKVIFLGFRNDVSEIlSAMD----VFLFPSLyEGLPLVAVEAQASGLPCLLSDTITKECDITNNVEFLPLNETP 317
|
170
....*....|...
gi 1777466523 366 VHFSEAMENFIHE 378
Cdd:cd03812 318 STWAEKILKLIKR 330
|
|
| |
