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Conserved domains on  [gi|1774455548|gb|QGG55769|]
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antibiotic biosynthesis monooxygenase [Paenibacillus sp. B01]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-95 1.97e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.50  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774455548   1 MILEHALLSVIPGKEADFERDFRTASAIISSMRGYVRHTLSRCLEQPSRYLLLVEWETLEDHTHGFRGSADygrwKALLH 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEH----RAAHA 76

                          90
                  ....*....|....*...
gi 1774455548  81 H---YYDPFPTVEHYTEV 95
Cdd:COG2329    77 KgreILAGPPRVEHYEVV 94
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-95 1.97e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.50  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774455548   1 MILEHALLSVIPGKEADFERDFRTASAIISSMRGYVRHTLSRCLEQPSRYLLLVEWETLEDHTHGFRGSADygrwKALLH 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEH----RAAHA 76

                          90
                  ....*....|....*...
gi 1774455548  81 H---YYDPFPTVEHYTEV 95
Cdd:COG2329    77 KgreILAGPPRVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 1.78e-10

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 52.27  E-value: 1.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774455548   2 ILEHALLSVIPGKEADFERDFRTASAIISSMRGYVRHTLSRCLEQPSRYLLLVEWETLEDHTHgFRGSADYGRW 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEA-HLQSPHFKAA 73
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-95 1.97e-20

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 78.50  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774455548   1 MILEHALLSVIPGKEADFERDFRTASAIISSMRGYVRHTLSRCLEQPSRYLLLVEWETLEDHTHGFRGSADygrwKALLH 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEH----RAAHA 76

                          90
                  ....*....|....*...
gi 1774455548  81 H---YYDPFPTVEHYTEV 95
Cdd:COG2329    77 KgreILAGPPRVEHYEVV 94
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 1.78e-10

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 52.27  E-value: 1.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774455548   2 ILEHALLSVIPGKEADFERDFRTASAIISSMRGYVRHTLSRCLEQPSRYLLLVEWETLEDHTHgFRGSADYGRW 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEA-HLQSPHFKAA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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