NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1770967247|ref|NP_001362527|]
View 

zinc finger protein 260 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
25-406 2.16e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247  25 KPYECNECRKTFSLKQNLVEHKKMHTGEKSHECT--ECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKafSQKENFLSHQ 102
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 103 KHHTGEKPYECEKVSIQ---------------MPTIIRHQKNHTGTK-------------PYACKECGKAFNGKAYLTEH 154
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPGNNSssvntpqsnslhpPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 155 EKIHTGEKPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSS 234
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 235 LIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGE 301
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 302 KPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECGKA 368
Cdd:COG5048   350 SPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKS 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1770967247 369 FSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 406
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
25-406 2.16e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247  25 KPYECNECRKTFSLKQNLVEHKKMHTGEKSHECT--ECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKafSQKENFLSHQ 102
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 103 KHHTGEKPYECEKVSIQ---------------MPTIIRHQKNHTGTK-------------PYACKECGKAFNGKAYLTEH 154
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPGNNSssvntpqsnslhpPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 155 EKIHTGEKPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSS 234
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 235 LIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGE 301
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 302 KPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECGKA 368
Cdd:COG5048   350 SPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKS 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1770967247 369 FSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 406
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 194-298 1.31e-04

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 44.09  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 194 CSECGKAFSQKEnliIHQRIHTGEKPYECkGCGkAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NL 263
Cdd:PLN03086  456 CEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1770967247 264 TEHEKIhIGEKPYKCNECGtifrqKQYLIKHHNIH 298
Cdd:PLN03086  531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-399 6.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.78e-04
                          10        20
                  ....*....|....*....|....*
gi 1770967247 375 LALHMRIHTGEKPYQCSECGKAFSQ 399
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 162-214 4.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1770967247 162 KPFeCNQCGRAFSQKQYLIKHQNIHTgkkpFKCSECGKAFSQKENLIIH-QRIH 214
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
25-406 2.16e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247  25 KPYECNECRKTFSLKQNLVEHKKMHTGEKSHECT--ECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKafSQKENFLSHQ 102
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 103 KHHTGEKPYECEKVSIQ---------------MPTIIRHQKNHTGTK-------------PYACKECGKAFNGKAYLTEH 154
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPGNNSssvntpqsnslhpPLPANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 155 EKIHTGEKPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSS 234
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 235 LIRHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGE 301
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 302 KPYEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSHTGEKPygCNECGKA 368
Cdd:COG5048   350 SPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKS 427

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1770967247 369 FSQFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 406
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-412 2.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247  83 YKCNKCGKAFSQKENFLSHQKHHTGEKPY-----ECEKVSIQMPTIIRHQKNHTGTKPYACKECGKAFNGKAYLTEHEKI 157
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcsysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 158 HTGEkPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCSECGKAFSQKENLIIHQRIHTGEKPYECKGCGKafiqKSSLIR 237
Cdd:COG5048   114 SSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS----NLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 238 HQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIF------RQKQYLIKHHNIHTGEKPYECNKCGK 311
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 312 AFSRITSLIVHVRIHTG-DKPYECKVCGKAFCQSSSLTVHMRS--HTGE--KPYGCNE--CGKAFSQFSTLALHMRIHTG 384
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350
                  ....*....|....*....|....*....|
gi 1770967247 385 EKPYQC--SECGKAFSQKSHHIRHQRIHTH 412
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNNEPPQSLQQY 378
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-412 3.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 162 KPFECNQCGRAFSQKQYLIKHQNIHTGKKPFKCS--ECGKAFSQKENLIIHQRIHTGEKPYEC-KGCGKAFIQKSSLIRH 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 239 QRSHTGEKPYTCKECGKAFSGKSNLTEHE--KIHIGEKPYK-CNECGTIFRQKQYLI-------------------KHHN 296
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLlsISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 297 IHTGEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCG----------------------------------KAFC 342
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1770967247 343 QSSSLTVHMRSHTG-EKPYGCNECGKAFSQFSTLALHMR--IHTGE--KPYQCSE--CGKAFSQKSHHIRHQRIHTH 412
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 194-298 1.31e-04

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 44.09  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247 194 CSECGKAFSQKEnliIHQRIHTGEKPYECkGCGkAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NL 263
Cdd:PLN03086  456 CEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1770967247 264 TEHEKIhIGEKPYKCNECGtifrqKQYLIKHHNIH 298
Cdd:PLN03086  531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 64-186 2.35e-04

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 43.32  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770967247  64 CSRVSSLTLH------LRSHTGKKAYKCNKCGKAFSQKEnflsHQKH-HTGEKPYECE-KVSIQMPTIIRHQKNHTGTKP 135
Cdd:PLN03086  429 CSRHNVVCPHdgcgivLRVEEAKNHVHCEKCGQAFQQGE----MEKHmKVFHEPLQCPcGVVLEKEQMVQHQASTCPLRL 504

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770967247 136 YACKECGKAFNGKAY----------LTEHEKIhTGEKPFECNQCGRAFsqkqyLIKHQNIH 186
Cdd:PLN03086  505 ITCRFCGDMVQAGGSamdvrdrlrgMSEHESI-CGSRTAPCDSCGRSV-----MLKEMDIH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-399 6.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.78e-04
                          10        20
                  ....*....|....*....|....*
gi 1770967247 375 LALHMRIHTGEKPYQCSECGKAFSQ 399
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-258 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 1770967247 234 SLIRHQRSHTGEKPYTCKECGKAFS 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 162-214 4.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1770967247 162 KPFeCNQCGRAFSQKQYLIKHQNIHTgkkpFKCSECGKAFSQKENLIIH-QRIH 214
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
150-175 6.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 1770967247 150 YLTEHEKIHTGEKPFECNQCGRAFSQ 175
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-231 7.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1770967247 206 NLIIHQRIHTGEKPYECKGCGKAFIQ 231
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 8.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|....
gi 1770967247 318 SLIVHVRIHTGDKPYECKVCGKAF 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
178-203 9.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1770967247 178 YLIKHQNIHTGKKPFKCSECGKAFSQ 203
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH