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Conserved domains on  [gi|1770792584|gb|QFU80851|]
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NSP1 [Rotavirus A]

Protein Classification

non-structural protein 1( domain architecture ID 10469892)

rotavirus non-structural protein 1 (NSP1) plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rota_NS53 pfam00981
Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded ...
 8-493 0e+00

Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded by gene 5. It is made in low levels in the infected cells and is a component of early replication. The protein is known to accumulate on the cytoskeleton of the infected cell. NS53 is an RNA binding protein that contains a characteriztic cysteine rich region.


:

Pssm-ID: 144538  Cd Length: 488  Bit Score: 855.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584   8 MATFKDACYYYKRINKLNHAVLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYDRCFLDDQPHL 87
Cdd:pfam00981   1 MATFKDACYHYRKINKLNREVLKLGANDVWRPAPPTKIKGWCLDCCQHTDLTYCRGCSLYHVCQWCSQYGRCFLDNEPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584  88 LRMRTFKNEVTKNDLMNLIDMYNILFPINQRIVDKFISNTRQHKCRNECMTQWYNHLLMPITLQSLSIELDGDVYYIFGY 167
Cdd:pfam00981  81 LRMRTFKNPITKEDLQNLIDMYNTLFPINEKIVNKFINNVKQRKCRNEYLIEWYNHLLLPITLQALSIKLDGDVYYIFGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 168 YDSMRDINQTPFSFTNLIDMYDKLLLDNVNFNRMSFLPVSLQQEYALRYFSKSRFISEKRKCISDLHFSTNVIENLHNPS 247
Cdd:pfam00981 161 YDGMENENQTPFRFVNLIDIYDKLLLDDINFDRMSFLPVSLQQEYALRYFSKSRFISEKLKQIYYSDFSKNTLENLHNPT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 248 FKIQITRNCSELSSDWNGTCKLVKDMSTYFNVLKTSHIEFYSISTRCRMYTQHKLKIVSKHIKPNYVTSNHRTSATEVHN 327
Cdd:pfam00981 241 SKRQVTRNCTEMDFNWNEECKLIVDKNKYLEALKTSYTEHYSVSDRCLGFTKYKLFELSKLIKPNYIASNHWQPASEVHN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 328 CKWCSINNGYTVWNDFRIKKIYDNIFNFLRALVKSNSNIGHCSSQEKIYEYIKDVLDVCDDEKWKMAVTEIFNCLEPVEL 407
Cdd:pfam00981 321 CKWCSINNSFKVWNDFRIRKIYNNLMSFIRALVKSNVNVGHCSSQESIYPYIKNVFWVCKTEKWNESVEKLFNCLEPVEI 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 408 DTVKYVLFNHEVNWDVINLLVHSV-GKVPQILTLNDIIIIMKSIIYEWFDIRYMRNTPMTTFTVDKLRQLCTGVKTVD-Y 485
Cdd:pfam00981 401 DGVEYVLFNHEINWELYNVIKQILnGEVPFILTLNDVKSILKAIIYDWFDIRYMRETPMTTFTTNKLRELNKRGKLSEeY 480


                  ....*...
gi 1770792584 486 DSGISDVE 493
Cdd:pfam00981 481 DLLISDSE 488
 
Name Accession Description Interval E-value
Rota_NS53 pfam00981
Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded ...
 8-493 0e+00

Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded by gene 5. It is made in low levels in the infected cells and is a component of early replication. The protein is known to accumulate on the cytoskeleton of the infected cell. NS53 is an RNA binding protein that contains a characteriztic cysteine rich region.


Pssm-ID: 144538  Cd Length: 488  Bit Score: 855.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584   8 MATFKDACYYYKRINKLNHAVLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYDRCFLDDQPHL 87
Cdd:pfam00981   1 MATFKDACYHYRKINKLNREVLKLGANDVWRPAPPTKIKGWCLDCCQHTDLTYCRGCSLYHVCQWCSQYGRCFLDNEPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584  88 LRMRTFKNEVTKNDLMNLIDMYNILFPINQRIVDKFISNTRQHKCRNECMTQWYNHLLMPITLQSLSIELDGDVYYIFGY 167
Cdd:pfam00981  81 LRMRTFKNPITKEDLQNLIDMYNTLFPINEKIVNKFINNVKQRKCRNEYLIEWYNHLLLPITLQALSIKLDGDVYYIFGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 168 YDSMRDINQTPFSFTNLIDMYDKLLLDNVNFNRMSFLPVSLQQEYALRYFSKSRFISEKRKCISDLHFSTNVIENLHNPS 247
Cdd:pfam00981 161 YDGMENENQTPFRFVNLIDIYDKLLLDDINFDRMSFLPVSLQQEYALRYFSKSRFISEKLKQIYYSDFSKNTLENLHNPT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 248 FKIQITRNCSELSSDWNGTCKLVKDMSTYFNVLKTSHIEFYSISTRCRMYTQHKLKIVSKHIKPNYVTSNHRTSATEVHN 327
Cdd:pfam00981 241 SKRQVTRNCTEMDFNWNEECKLIVDKNKYLEALKTSYTEHYSVSDRCLGFTKYKLFELSKLIKPNYIASNHWQPASEVHN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 328 CKWCSINNGYTVWNDFRIKKIYDNIFNFLRALVKSNSNIGHCSSQEKIYEYIKDVLDVCDDEKWKMAVTEIFNCLEPVEL 407
Cdd:pfam00981 321 CKWCSINNSFKVWNDFRIRKIYNNLMSFIRALVKSNVNVGHCSSQESIYPYIKNVFWVCKTEKWNESVEKLFNCLEPVEI 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 408 DTVKYVLFNHEVNWDVINLLVHSV-GKVPQILTLNDIIIIMKSIIYEWFDIRYMRNTPMTTFTVDKLRQLCTGVKTVD-Y 485
Cdd:pfam00981 401 DGVEYVLFNHEINWELYNVIKQILnGEVPFILTLNDVKSILKAIIYDWFDIRYMRETPMTTFTTNKLRELNKRGKLSEeY 480


                  ....*...
gi 1770792584 486 DSGISDVE 493
Cdd:pfam00981 481 DLLISDSE 488
 
Name Accession Description Interval E-value
Rota_NS53 pfam00981
Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded ...
 8-493 0e+00

Rotavirus RNA-binding Protein 53 (NS53); This protein is also known as NSP1. NS53 is encoded by gene 5. It is made in low levels in the infected cells and is a component of early replication. The protein is known to accumulate on the cytoskeleton of the infected cell. NS53 is an RNA binding protein that contains a characteriztic cysteine rich region.


Pssm-ID: 144538  Cd Length: 488  Bit Score: 855.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584   8 MATFKDACYYYKRINKLNHAVLKLGVNDTWRPSPPTKYKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYDRCFLDDQPHL 87
Cdd:pfam00981   1 MATFKDACYHYRKINKLNREVLKLGANDVWRPAPPTKIKGWCLDCCQHTDLTYCRGCSLYHVCQWCSQYGRCFLDNEPHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584  88 LRMRTFKNEVTKNDLMNLIDMYNILFPINQRIVDKFISNTRQHKCRNECMTQWYNHLLMPITLQSLSIELDGDVYYIFGY 167
Cdd:pfam00981  81 LRMRTFKNPITKEDLQNLIDMYNTLFPINEKIVNKFINNVKQRKCRNEYLIEWYNHLLLPITLQALSIKLDGDVYYIFGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 168 YDSMRDINQTPFSFTNLIDMYDKLLLDNVNFNRMSFLPVSLQQEYALRYFSKSRFISEKRKCISDLHFSTNVIENLHNPS 247
Cdd:pfam00981 161 YDGMENENQTPFRFVNLIDIYDKLLLDDINFDRMSFLPVSLQQEYALRYFSKSRFISEKLKQIYYSDFSKNTLENLHNPT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 248 FKIQITRNCSELSSDWNGTCKLVKDMSTYFNVLKTSHIEFYSISTRCRMYTQHKLKIVSKHIKPNYVTSNHRTSATEVHN 327
Cdd:pfam00981 241 SKRQVTRNCTEMDFNWNEECKLIVDKNKYLEALKTSYTEHYSVSDRCLGFTKYKLFELSKLIKPNYIASNHWQPASEVHN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 328 CKWCSINNGYTVWNDFRIKKIYDNIFNFLRALVKSNSNIGHCSSQEKIYEYIKDVLDVCDDEKWKMAVTEIFNCLEPVEL 407
Cdd:pfam00981 321 CKWCSINNSFKVWNDFRIRKIYNNLMSFIRALVKSNVNVGHCSSQESIYPYIKNVFWVCKTEKWNESVEKLFNCLEPVEI 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770792584 408 DTVKYVLFNHEVNWDVINLLVHSV-GKVPQILTLNDIIIIMKSIIYEWFDIRYMRNTPMTTFTVDKLRQLCTGVKTVD-Y 485
Cdd:pfam00981 401 DGVEYVLFNHEINWELYNVIKQILnGEVPFILTLNDVKSILKAIIYDWFDIRYMRETPMTTFTTNKLRELNKRGKLSEeY 480


                  ....*...
gi 1770792584 486 DSGISDVE 493
Cdd:pfam00981 481 DLLISDSE 488
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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