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Conserved domains on  [gi|1770760132|ref|WP_152579199|]
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phosphatase PAP2 family protein [Polymorphobacter fuscus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130261)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Bacillus subtilis phosphatidylglycerophosphatase B that catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol

CATH:  1.20.144.10
PubMed:  9122162
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-225 7.17e-40

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


:

Pssm-ID: 239486  Cd Length: 182  Bit Score: 135.43  E-value: 7.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  40 VRTGETTRFDTAIMLALRHaddlaspIGPRWLERTMVDLTALGGVTLLTLVTLIVMGFLLTQRKYAEAAFVGIAIGGGAL 119
Cdd:cd03392     4 VQAGWLTAFDQSVLSLLRS-------LRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 120 LGSLLKASYARTRPSLVaHLVEVNSASFPSAHAMNSAITYLTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGV 199
Cdd:cd03392    77 LNTLLKLLVQRPRPPLH-LLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGV 155

                         170       180
                  ....*....|....*....|....*.
gi 1770760132 200 HWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:cd03392   156 HYPSDVLAGWLLGLAWLALLILLYRR 181
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-225 7.17e-40

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 135.43  E-value: 7.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  40 VRTGETTRFDTAIMLALRHaddlaspIGPRWLERTMVDLTALGGVTLLTLVTLIVMGFLLTQRKYAEAAFVGIAIGGGAL 119
Cdd:cd03392     4 VQAGWLTAFDQSVLSLLRS-------LRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 120 LGSLLKASYARTRPSLVaHLVEVNSASFPSAHAMNSAITYLTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGV 199
Cdd:cd03392    77 LNTLLKLLVQRPRPPLH-LLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGV 155

                         170       180
                  ....*....|....*....|....*.
gi 1770760132 200 HWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:cd03392   156 HYPSDVLAGWLLGLAWLALLILLYRR 181
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 48-225 1.56e-19

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 82.78  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  48 FDTAIMLALRHADDLASPIGPRWLERTMVDLTALGGVTLLTLVTLIVMGFLLTQRKYAEAAFV----GIAIGGGALLGSL 123
Cdd:COG0671    12 LLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLlllaALLLLLLLLLLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 124 LKASYARTRP----SLVAHLVEVNSASFPSAHAMNSAITYLTLGVLVARAasthrekaYAMWVALLLTLVVGVSRVYLGV 199
Cdd:COG0671    92 LKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRR--------WLAALLLALALLVGLSRVYLGV 163

                         170       180
                  ....*....|....*....|....*.
gi 1770760132 200 HWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:COG0671   164 HYPSDVLAGALLGLAIALLLLALLRR 189
acidPPc smart00014
Acid phosphatase homologues;
127-220 9.15e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 70.84  E-value: 9.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  127 SYARTRPSLVAHLVEVNSASFPSAHAMNSAITYLtlgvLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVI 206
Cdd:smart00014  27 SIGDACCTPNFLLTLEAGYSFPSGHTAFAFAFAL----FLLLYLPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVL 102

                           90
                   ....*....|....
gi 1770760132  207 AGWAVGSAWAVTCW 220
Cdd:smart00014 103 AGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 110-225 1.82e-12

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 62.05  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 110 VGIAIGGGALLGSLLKASYARTRPSLVAHL---------VEVNSASFPSAHAMNSAITYLTLGVLVARAASTHREKAYam 180
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEgglvpapstLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLA-- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1770760132 181 WVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 148-214 1.64e-05

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 45.11  E-value: 1.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1770760132 148 PSAHAMNSAIT--YLTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSA 214
Cdd:PLN02525   87 PSSHTLNTVCLsgYLLHYVLSYLQNVDASVIFAGLALFCLLVALVGFGRLYLGMHSPIDIIAGLAIGLV 155
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 40-225 7.17e-40

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 135.43  E-value: 7.17e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  40 VRTGETTRFDTAIMLALRHaddlaspIGPRWLERTMVDLTALGGVTLLTLVTLIVMGFLLTQRKYAEAAFVGIAIGGGAL 119
Cdd:cd03392     4 VQAGWLTAFDQSVLSLLRS-------LRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALFLLLALLGGGA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 120 LGSLLKASYARTRPSLVaHLVEVNSASFPSAHAMNSAITYLTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGV 199
Cdd:cd03392    77 LNTLLKLLVQRPRPPLH-LLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGV 155

                         170       180
                  ....*....|....*....|....*.
gi 1770760132 200 HWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:cd03392   156 HYPSDVLAGWLLGLAWLALLILLYRR 181
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 48-225 1.56e-19

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 82.78  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  48 FDTAIMLALRHADDLASPIGPRWLERTMVDLTALGGVTLLTLVTLIVMGFLLTQRKYAEAAFV----GIAIGGGALLGSL 123
Cdd:COG0671    12 LLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLlllaALLLLLLLLLLLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 124 LKASYARTRP----SLVAHLVEVNSASFPSAHAMNSAITYLTLGVLVARAasthrekaYAMWVALLLTLVVGVSRVYLGV 199
Cdd:COG0671    92 LKYLFGRPRPfvvpDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRR--------WLAALLLALALLVGLSRVYLGV 163

                         170       180
                  ....*....|....*....|....*.
gi 1770760132 200 HWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:COG0671   164 HYPSDVLAGALLGLAIALLLLALLRR 189
acidPPc smart00014
Acid phosphatase homologues;
127-220 9.15e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 70.84  E-value: 9.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  127 SYARTRPSLVAHLVEVNSASFPSAHAMNSAITYLtlgvLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVI 206
Cdd:smart00014  27 SIGDACCTPNFLLTLEAGYSFPSGHTAFAFAFAL----FLLLYLPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVL 102

                           90
                   ....*....|....
gi 1770760132  207 AGWAVGSAWAVTCW 220
Cdd:smart00014 103 AGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 107-220 1.58e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 67.49  E-value: 1.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 107 AAFVGIAIGGGALLGSLLKASYARTRPSLVAHLVEVN--------SASFPSAHAMNSAITYLTLGVLVARaastHREKAY 178
Cdd:cd01610     5 ALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGdpllltegGYSFPSGHAAFAFALALFLALLLPR----RLLRLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1770760132 179 AMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCW 220
Cdd:cd01610    81 LGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 125-223 1.73e-14

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 68.83  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 125 KASYARTRPS-------LVAHLVEVNSASFPSAHAMNSAITYLTLGVLvaraastHREKAYAmWVALLLTLVVGVSRVYL 197
Cdd:cd03395    77 KPLVARLRPCnaldgvrLVVLGDQGGSYSFASSHAANSFALALFIWLF-------FRRGLFS-PVLLLWALLVGYSRVYV 148

                          90       100
                  ....*....|....*....|....*.
gi 1770760132 198 GVHWPTDVIAGWAVGSAWAVTCWIIA 223
Cdd:cd03395   149 GVHYPGDVIAGALIGIISGLLFYLLF 174
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 110-225 1.82e-12

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 62.05  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 110 VGIAIGGGALLGSLLKASYARTRPSLVAHL---------VEVNSASFPSAHAMNSAITYLTLGVLVARAASTHREKAYam 180
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEgglvpapstLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLA-- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1770760132 181 WVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCWIIAER 225
Cdd:pfam01569  80 LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 132-222 7.31e-09

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 53.00  E-value: 7.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 132 RPSLV-AHLVEVNSA----SFPSAHAMNS-AITYLTLGVLVARAASThrekAYAMWV-ALLLTLVVGVSRVYLGVHWPTD 204
Cdd:cd03388    60 RPSSPpVVRLTMSSAaleyGFPSTHAMNAtAISFYLLIYLYDRYQYP----FVLGLIlALFYSTLVCLSRIYMGMHSVLD 135

                          90
                  ....*....|....*...
gi 1770760132 205 VIAGWAVGsawaVTCWII 222
Cdd:cd03388   136 VIAGSLIG----VLILLF 149
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 146-212 1.56e-08

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 51.60  E-value: 1.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1770760132 146 SFPSAHAMNSAITYLTLGVLVARAASThrekayamWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVG 212
Cdd:cd03393    59 GFPSGHAQTSATFWGSLMLHVRKKWFT--------LIGVVLVVLISFSRLYLGVHWPSDVIGGVLIG 117
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 135-219 1.12e-07

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 49.56  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 135 LVAHLVEvnsASFPSAHamnsaitylTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSA 214
Cdd:cd03385    70 LLPHAAD---SSFPSDH---------TTLFFSIAFSLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVL 137


                  ....*
gi 1770760132 215 WAVTC 219
Cdd:cd03385   138 SALLV 142
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 86-220 1.22e-07

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 49.58  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132  86 LLTLVTLIVMGFLLTQ---RKYAEAAFVGIAIGGGALLGSLLKASYARTRPSLVAHLVEVNSAsFPSAHA--MNSAITYL 160
Cdd:cd03382    20 YLSLLPVAILVGYATLilfRRELEAIYLFIGLLANEALNYVLKRIIKEPRPCSGAYFVRSGYG-MPSSHSqfMGFFAVYL 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1770760132 161 TLGVLVARAASTHREKAYAMWVALL-LTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCW 220
Cdd:cd03382    99 LLFIYLRLGRLNSLVSRFLLSLGLLlLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILWF 159
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 145-222 1.21e-06

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 47.32  E-value: 1.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1770760132 145 ASFPSAHAMNSAITYLTLGVLVARaastHRekayamWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCWII 222
Cdd:cd03389   118 TSFPSGHSATAGAAAAALALLFPR----YR------WAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQR 185
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 125-233 2.63e-06

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 46.94  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 125 KASYARTRPSLVAHLVEVN---------SASFPSAHAmnsaityltlgvlvaraasthrekAYAMWVALLLTLVV----- 190
Cdd:cd03397   121 KKYYNRPRPFVLNDEPICTppdesglakDGSYPSGHT------------------------AAGYAWALILAELVperad 176

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1770760132 191 ---------GVSRVYLGVHWPTDVIAGWAVGSAWAVTCWIIAERVRAPSVAR 233
Cdd:cd03397   177 eilargseyGQSRIVCGVHWPSDVMGGRIMAAALVAALLADPAFAADLAAAR 228
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 107-214 3.53e-06

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 46.27  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 107 AAFVGIAIGGGALLGSLLKASYARTRP-------SLVAHLVEVNSA---SFPSAHAMNSAITYLTLGVLVARAASTHREK 176
Cdd:cd03380    95 YALLARALTDAGIATWDAKYHYNRPRPfvairlqWLPICTPEEGTPkhpSYPSGHATFGGAAALVLAELFPERAAELLAR 174

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1770760132 177 AYAmwvallltlvVGVSRVYLGVHWPTDVIAGWAVGSA 214
Cdd:cd03380   175 AAE----------AGNSRVVAGVHWPSDVEAGRILGEA 202
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 148-214 1.64e-05

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 45.11  E-value: 1.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1770760132 148 PSAHAMNSAIT--YLTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSA 214
Cdd:PLN02525   87 PSSHTLNTVCLsgYLLHYVLSYLQNVDASVIFAGLALFCLLVALVGFGRLYLGMHSPIDIIAGLAIGLV 155
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 146-212 4.60e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 42.31  E-value: 4.60e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1770760132 146 SFPSAHAmnsaitylTLGVLVARAASTHREKAYAMWVALLL-TLVVGVSRVYLGVHWPTDVIAGWAVG 212
Cdd:cd03391    92 SFPSGHA--------SRAAFVARFLLNHLVLAVPLRVLLVLwATVVGISRVLLGRHHVLDVLAGAFLG 151
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
 148-219 1.93e-04

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 41.21  E-value: 1.93e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1770760132 148 PSAHAMNSAITYLtlgVLVARAASTHREKAYAMWVALLLTLV-------VGVSRVYLGVHWPTDVIAGWAVGSAWAVTC 219
Cdd:cd03381    75 PSGHAMGTTAVLL---VMVTALLSHLAGRKRSRFLRVMLWLVfwgvqlaVCLSRIYLAAHFPHQVIAGVISGIAVAETF 150
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 146-218 2.50e-04

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 39.24  E-value: 2.50e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770760132 146 SFPSAHamnSAITYLTLGVLVARAASthreKAYAMWVALLLTLVvGVSRVYLGVHWPTDVIAGWAVG--SAWAVT 218
Cdd:cd03394    40 SFPSGH---TASAFAAATFLQYRYGW----RWYGIPAYALASLV-GASRVVANRHWLSDVLAGAAIGilVGYLVT 106
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 146-220 4.24e-04

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 39.90  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 146 SFPSAHA--MNSAITYLTL---GVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSAWAVTCW 220
Cdd:cd03390   111 SFPSGHSsfAFAGLGFLSLylaGKLHIFDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSY 190
PAP2_3 pfam14378
PAP2 superfamily;
145-214 8.98e-04

PAP2 superfamily;


Pssm-ID: 433919  Cd Length: 190  Bit Score: 38.86  E-value: 8.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 145 ASFPSAHAmnsaitylTLGVLVARAASTHREKAYAMWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVGSA 214
Cdd:pfam14378 125 AAMPSLHV--------AWALLCALALWRLRRTRILRWLAVAYNVLMIVSTVATGNHYLLDVVAGVALALA 186
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 145-227 9.29e-04

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 38.83  E-value: 9.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 145 ASFPSAHAMNSaityltlgVLVARAASTHREKAYAmWVALLLTLVVGVSRVYLGVHWPTDVIAGWAVgsawAVTCWIIAE 224
Cdd:cd03386   117 NAFPSLHVAWA--------VLAALFLWRHRRRLLR-WLAVLWPLLIWLSTLYLGNHYFIDLVGGIAL----ALLSFYLAR 183


                  ...
gi 1770760132 225 RVR 227
Cdd:cd03386   184 RVR 186
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 182-212 1.59e-03

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 38.45  E-value: 1.59e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770760132 182 VALLLTLVVGVSRVYLGVHWPTDVIAGWAVG 212
Cdd:PRK11837  131 LLMAIAVAIAWSRVYLGVHWPLDMLGALLVG 161
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 146-229 5.13e-03

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 36.93  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770760132 146 SFPSAHAMNSAI-TYLTLGVLVARAasthrekaYAMWVALLLTLVVGV--SRVYLGVHWPTDVIAGWAVgSAWAVT--CW 220
Cdd:PRK10699  158 AFPSGHTMFAASwALLAVGLLWPRR--------RYKTVALLMLWATGVmgSRLLLGMHWPRDLVVATLI-SWLLVTvaTW 228


                  ....*....
gi 1770760132 221 iIAERVRAP 229
Cdd:PRK10699  229 -LAQRICGP 236
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 146-219 5.30e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 36.89  E-value: 5.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770760132 146 SFPSAHAMnSAITYLTLGVLVARAASTHRekAYAMWVALLLTLVVGVSRVYLGVHWPTDVIagWAVGSAWAVTC 219
Cdd:cd03396   123 SFPSGHAS-AGFALLALYFLFRRRRPRLA--RLVLAAGLALGALMGLARMARGAHFLSDVL--WSLLLVWLIAL 191
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 190-212 9.06e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 36.25  E-value: 9.06e-03
                          10        20
                  ....*....|....*....|...
gi 1770760132 190 VGVSRVYLGVHWPTDVIAGWAVG 212
Cdd:cd03398   201 VAISRVYAGVHFRSDDAAGAALG 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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