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Conserved domains on  [gi|1769169718|gb|QFS19124|]
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polyprotein, partial [dengue virus type 2]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flavi_glycoprot super family cl02995
Flavivirus glycoprotein, central and dimerization domains;
105-399 5.50e-139

Flavivirus glycoprotein, central and dimerization domains;


The actual alignment was detected with superfamily member pfam00869:

Pssm-ID: 395698  Cd Length: 300  Bit Score: 407.13  E-value: 5.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 105 RCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELTKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPS 184
Cdd:pfam00869   1 HCIGIGDRDFIEGLHGATWVDATLEHDKCVTTMAKDKPSLDIELEKTAIDNPAELRKLCIEAKISHTKIDDKCPSQGEAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 185 LNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGTE 264
Cdd:pfam00869  81 LAEENDGDFACKRTFSDRGHGNGCGLFGKGSIIACAKFKCAKKLEGFEVDQEKIKYSIIAQLHTGAKHENGNEDIEHGTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 265 IKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLL**E*K*W*VHRQW*LDLPLPWLPGADKQGSNWIQKETLVTFK 344
Cdd:pfam00869 161 AKFDALAGSQEIEFIDYGAATLDCQPQTALDFGEMVIAEMEKESWIVDKQWALDLPLPWQSGASTSGETWNEMDHLVEFE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 345 NPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNL-----LFTGHLKCRLRMDKLQLKG 399
Cdd:pfam00869 241 PAHAAKIEVLALGNQEGALHTALTGAMEIQTKDTNDnnlykIFAGHLKCRLKLDALTLKG 300
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 408-497 1.82e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


:

Pssm-ID: 213392  Cd Length: 91  Bit Score: 145.14  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 408 KFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMD-LEKRHALGRLITVNPIVTEKDSPVNIEAEPPFGDSYIVIGVE 486
Cdd:cd12149     1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVG 80

                          90
                  ....*....|.
gi 1769169718 487 PGQLKLSWFKK 497
Cdd:cd12149    81 DTRLKHQWFQK 91
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 502-574 5.22e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


:

Pssm-ID: 213897  Cd Length: 97  Bit Score: 133.15  E-value: 5.22e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769169718 502 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 574
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
Flavi_M super family cl03065
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 30-103 1.21e-27

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


The actual alignment was detected with superfamily member pfam01004:

Pssm-ID: 470726  Cd Length: 74  Bit Score: 106.13  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769169718  30 VALVPHVGMGLETRTETWMSSEGAWKHAQRIETWVLRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSLT 103
Cdd:pfam01004   1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
Flavi_NS1 super family cl03032
Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the ...
 600-634 4.11e-12

Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins. Mutational analysis has strongly implied a role for NS1 in the early stages of RNA replication.


The actual alignment was detected with superfamily member pfam00948:

Pssm-ID: 279316  Cd Length: 360  Bit Score: 68.14  E-value: 4.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1769169718 600 SGCVVSWKNKELKCGSGIFITDNVHTWTEQYKFQP 634
Cdd:pfam00948   1 QGCAINFGGRELKCGDGIFIFNDSDDWLEKYKFQA 35
 
Name Accession Description Interval E-value
Flavi_glycoprot pfam00869
Flavivirus glycoprotein, central and dimerization domains;
105-399 5.50e-139

Flavivirus glycoprotein, central and dimerization domains;


Pssm-ID: 395698  Cd Length: 300  Bit Score: 407.13  E-value: 5.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 105 RCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELTKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPS 184
Cdd:pfam00869   1 HCIGIGDRDFIEGLHGATWVDATLEHDKCVTTMAKDKPSLDIELEKTAIDNPAELRKLCIEAKISHTKIDDKCPSQGEAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 185 LNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGTE 264
Cdd:pfam00869  81 LAEENDGDFACKRTFSDRGHGNGCGLFGKGSIIACAKFKCAKKLEGFEVDQEKIKYSIIAQLHTGAKHENGNEDIEHGTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 265 IKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLL**E*K*W*VHRQW*LDLPLPWLPGADKQGSNWIQKETLVTFK 344
Cdd:pfam00869 161 AKFDALAGSQEIEFIDYGAATLDCQPQTALDFGEMVIAEMEKESWIVDKQWALDLPLPWQSGASTSGETWNEMDHLVEFE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 345 NPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNL-----LFTGHLKCRLRMDKLQLKG 399
Cdd:pfam00869 241 PAHAAKIEVLALGNQEGALHTALTGAMEIQTKDTNDnnlykIFAGHLKCRLKLDALTLKG 300
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 408-497 1.82e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 145.14  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 408 KFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMD-LEKRHALGRLITVNPIVTEKDSPVNIEAEPPFGDSYIVIGVE 486
Cdd:cd12149     1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVG 80

                          90
                  ....*....|.
gi 1769169718 487 PGQLKLSWFKK 497
Cdd:cd12149    81 DTRLKHQWFQK 91
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
401-496 4.56e-39

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 139.01  E-value: 4.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 401 SYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIP-FEIMDLEKRHALGRLITVNPIVTEKDSPVNIEAEPPFGDS 479
Cdd:pfam02832   1 SYKICTDKFFFEKEPADTGHGTVLMQVKVEGKDAPCKIPvFSADDEKAAINKGILITANPIASDKDDEVLIEAEPPFGDS 80

                          90
                  ....*....|....*..
gi 1769169718 480 YIVIGVEPGQLKLSWFK 496
Cdd:pfam02832  81 YIIVGAGDKALKLQWFK 97
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 502-574 5.22e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


Pssm-ID: 213897  Cd Length: 97  Bit Score: 133.15  E-value: 5.22e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769169718 502 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 574
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
Flavi_M pfam01004
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions ...
 30-103 1.21e-27

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 460022  Cd Length: 74  Bit Score: 106.13  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769169718  30 VALVPHVGMGLETRTETWMSSEGAWKHAQRIETWVLRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSLT 103
Cdd:pfam01004   1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
Flavi_M cd17038
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 29-101 1.49e-26

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 341208  Cd Length: 75  Bit Score: 103.10  E-value: 1.49e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769169718  29 SVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWVLRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPS 101
Cdd:cd17038     1 SVAIPPHGTGGLTTRKETWLSTSNGKEHLTRVERWVLRNPGYALAAVALAWMLGSSTTQRVIIIVLLLLVAPA 73
Flavi_NS1 pfam00948
Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the ...
 600-634 4.11e-12

Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins. Mutational analysis has strongly implied a role for NS1 in the early stages of RNA replication.


Pssm-ID: 279316  Cd Length: 360  Bit Score: 68.14  E-value: 4.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1769169718 600 SGCVVSWKNKELKCGSGIFITDNVHTWTEQYKFQP 634
Cdd:pfam00948   1 QGCAINFGGRELKCGDGIFIFNDSDDWLEKYKFQA 35
 
Name Accession Description Interval E-value
Flavi_glycoprot pfam00869
Flavivirus glycoprotein, central and dimerization domains;
105-399 5.50e-139

Flavivirus glycoprotein, central and dimerization domains;


Pssm-ID: 395698  Cd Length: 300  Bit Score: 407.13  E-value: 5.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 105 RCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELTKTEAKHPATLRKYCIEAKLTNTTTASRCPTQGEPS 184
Cdd:pfam00869   1 HCIGIGDRDFIEGLHGATWVDATLEHDKCVTTMAKDKPSLDIELEKTAIDNPAELRKLCIEAKISHTKIDDKCPSQGEAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 185 LNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEENAVGNDTGKHGTE 264
Cdd:pfam00869  81 LAEENDGDFACKRTFSDRGHGNGCGLFGKGSIIACAKFKCAKKLEGFEVDQEKIKYSIIAQLHTGAKHENGNEDIEHGTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 265 IKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLL**E*K*W*VHRQW*LDLPLPWLPGADKQGSNWIQKETLVTFK 344
Cdd:pfam00869 161 AKFDALAGSQEIEFIDYGAATLDCQPQTALDFGEMVIAEMEKESWIVDKQWALDLPLPWQSGASTSGETWNEMDHLVEFE 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 345 NPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNL-----LFTGHLKCRLRMDKLQLKG 399
Cdd:pfam00869 241 PAHAAKIEVLALGNQEGALHTALTGAMEIQTKDTNDnnlykIFAGHLKCRLKLDALTLKG 300
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 408-497 1.82e-41

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 145.14  E-value: 1.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 408 KFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMD-LEKRHALGRLITVNPIVTEKDSPVNIEAEPPFGDSYIVIGVE 486
Cdd:cd12149     1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDsGSGGENVGRLITVNPIITNANSKVFIEVEPPFGDSYIVVGVG 80

                          90
                  ....*....|.
gi 1769169718 487 PGQLKLSWFKK 497
Cdd:cd12149    81 DTRLKHQWFQK 91
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
401-496 4.56e-39

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 139.01  E-value: 4.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769169718 401 SYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIP-FEIMDLEKRHALGRLITVNPIVTEKDSPVNIEAEPPFGDS 479
Cdd:pfam02832   1 SYKICTDKFFFEKEPADTGHGTVLMQVKVEGKDAPCKIPvFSADDEKAAINKGILITANPIASDKDDEVLIEAEPPFGDS 80

                          90
                  ....*....|....*..
gi 1769169718 480 YIVIGVEPGQLKLSWFK 496
Cdd:pfam02832  81 YIIVGAGDKALKLQWFK 97
flavi_E_stem TIGR04240
flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal ...
 502-574 5.22e-37

flavivirus envelope glycoprotein E, stem/anchor domain; This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.


Pssm-ID: 213897  Cd Length: 97  Bit Score: 133.15  E-value: 5.22e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769169718 502 GQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSR 574
Cdd:TIGR04240   1 GKAFELTMRGAERMAILGDAAWDFGSVGGVFTSIGKALHQVFGGAFRALFGGVSWITKILIGVLLIWLGLNSR 73
Flavi_M pfam01004
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions ...
 30-103 1.21e-27

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 460022  Cd Length: 74  Bit Score: 106.13  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769169718  30 VALVPHVGMGLETRTETWMSSEGAWKHAQRIETWVLRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSLT 103
Cdd:pfam01004   1 VALPPHVGLGLETRTETWMSSRGAWKQLQKVETWALRNPGFTVIALFIAHLIGSSITQKVIIFILLLLVTPAYS 74
Flavi_M cd17038
Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a ...
 29-101 1.49e-26

Flavivirus envelope glycoprotein M; Flaviviruses are small enveloped viruses with a membrane-anchored envelope comprised of 3 proteins called C, M and E. The envelope glycoprotein M is translated as a precursor, called prM. The precursor portion of the protein is the signal peptide for the protein's entry into the membrane. prM is cleaved to form M by the proprotein convertase furin in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.


Pssm-ID: 341208  Cd Length: 75  Bit Score: 103.10  E-value: 1.49e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1769169718  29 SVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWVLRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPS 101
Cdd:cd17038     1 SVAIPPHGTGGLTTRKETWLSTSNGKEHLTRVERWVLRNPGYALAAVALAWMLGSSTTQRVIIIVLLLLVAPA 73
Flavi_NS1 pfam00948
Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the ...
 600-634 4.11e-12

Flavivirus non-structural Protein NS1; The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins. Mutational analysis has strongly implied a role for NS1 in the early stages of RNA replication.


Pssm-ID: 279316  Cd Length: 360  Bit Score: 68.14  E-value: 4.11e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1769169718 600 SGCVVSWKNKELKCGSGIFITDNVHTWTEQYKFQP 634
Cdd:pfam00948   1 QGCAINFGGRELKCGDGIFIFNDSDDWLEKYKFQA 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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