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Conserved domains on  [gi|1768365531|ref|NP_001362232|]
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protein jagged-2 isoform 2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 2-170 6.32e-69

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


:

Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.95  E-value: 6.32e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531    2 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 81
Cdd:pfam07657    2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531   82 AGAAGdrararsrtgghqDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 159
Cdd:pfam07657   80 LLKGS-------------FRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                          170
                   ....*....|.
gi 1768365531  160 HVAHLELQIRV 170
Cdd:pfam07657  147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
152-214 1.30e-24

delta serrate ligand;


:

Pssm-ID: 128366  Cd Length: 63  Bit Score: 97.79  E-value: 1.30e-24
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1768365531   152 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 214
Cdd:smart00051    1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
846-917 2.85e-15

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214565  Cd Length: 67  Bit Score: 71.44  E-value: 2.85e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1768365531   846 CWSRGVSFPHGSSWVEDCNSCRCLDGHRDCSKVWCGWKPCLLspqpSALSAQCPPGQQCREKAMGqCLQPPC 917
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLL----HNLSGECPLGQGCVPSLSD-CLSSPC 67
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 801-837 1.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  801 NIDECQS-SPCAYGATCVDEINGYRCSCPPGRSGPRCQ 837
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 359-395 2.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  359 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 395
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 435-470 2.65e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.65e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  435 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 470
Cdd:cd00054      1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-319 6.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 6.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1768365531  281 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 319
Cdd:cd00054      1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-645 8.28e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  610 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 645
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-432 8.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  397 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 432
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 510-545 1.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  510 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 545
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 771-798 1.94e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.94e-04
                           10        20
                   ....*....|....*....|....*...
gi 1768365531  771 PCYNGGICVDGVNWFRCECAPGFAGPDC 798
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 731-761 2.41e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.41e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  731 PNPCVNGGTCVGSGDSFSCICRDGWEGRTCT 761
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 476-508 1.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1768365531  476 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 508
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 325-355 1.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  325 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 355
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 650-683 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1768365531  650 NDCL-PDPCHSRGRCYDLVNDFYCVCDDGWKGKTC 683
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 690-720 2.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  690 CDAYTCSNGGTCYDSGDTFRCACPPGWKGST 720
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 2-170 6.32e-69

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.95  E-value: 6.32e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531    2 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 81
Cdd:pfam07657    2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531   82 AGAAGdrararsrtgghqDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 159
Cdd:pfam07657   80 LLKGS-------------FRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                          170
                   ....*....|.
gi 1768365531  160 HVAHLELQIRV 170
Cdd:pfam07657  147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
152-214 1.30e-24

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 97.79  E-value: 1.30e-24
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1768365531   152 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 214
Cdd:smart00051    1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 172-217 4.32e-18

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 78.82  E-value: 4.32e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1768365531  172 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 217
Cdd:pfam01414    1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
846-917 2.85e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 71.44  E-value: 2.85e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1768365531   846 CWSRGVSFPHGSSWVEDCNSCRCLDGHRDCSKVWCGWKPCLLspqpSALSAQCPPGQQCREKAMGqCLQPPC 917
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLL----HNLSGECPLGQGCVPSLSD-CLSSPC 67
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 801-837 1.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  801 NIDECQS-SPCAYGATCVDEINGYRCSCPPGRSGPRCQ 837
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 359-395 2.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  359 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 395
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 435-470 2.65e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.65e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  435 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 470
Cdd:cd00054      1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-319 6.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 6.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1768365531  281 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 319
Cdd:cd00054      1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-645 8.28e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  610 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 645
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
801-837 9.01e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.01e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   801 NIDECQS-SPCAYGATCVDEINGYRCSCPPG-RSGPRCQ 837
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
435-470 2.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.36e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   435 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGF-GGRHCE 470
Cdd:smart00179    1 DIDECasGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-432 8.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  397 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 432
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
610-641 1.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.02e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1768365531   610 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWE 641
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
359-395 1.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   359 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWV-GATCQ 395
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
281-319 1.29e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1768365531   281 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGY-LGKNCE 319
Cdd:smart00179    1 DIDECASGNPCQNGGTCVN-TVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 510-545 1.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  510 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 545
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 771-798 1.94e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.94e-04
                           10        20
                   ....*....|....*....|....*...
gi 1768365531  771 PCYNGGICVDGVNWFRCECAPGFAGPDC 798
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 731-761 2.41e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.41e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  731 PNPCVNGGTCVGSGDSFSCICRDGWEGRTCT 761
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-432 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 9.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1768365531   397 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWK-GANC 432
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 476-508 1.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1768365531  476 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 508
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 325-355 1.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  325 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 355
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 325-356 1.61e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1768365531  325 CAS-NPCANGGSCHEVLSGFECHCPSGWSGPTC 356
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 650-683 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1768365531  650 NDCL-PDPCHSRGRCYDLVNDFYCVCDDGWKGKTC 683
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 690-720 2.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  690 CDAYTCSNGGTCYDSGDTFRCACPPGWKGST 720
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 2.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  514 CEPNPCLNGARCYNLEDDYYCACPEDFGGKN 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-545 2.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1768365531   510 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDF-GGKNC 545
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-722 4.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.75e-03
                           10        20
                   ....*....|....*....|....*...
gi 1768365531  695 CSNGGTCYDSGDTFRCACPPGWKGSTCT 722
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 443-464 5.22e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.39  E-value: 5.22e-03
                           10        20
                   ....*....|....*....|..
gi 1768365531  443 CQHGGTCKDLVNGYQCVCPRGF 464
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 767-797 5.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 5.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  767 CNPLPCYNGGICVDGVNWFRCECAPGFAGPD 797
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
771-798 7.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.66e-03
                            10        20
                    ....*....|....*....|....*....
gi 1768365531   771 PCYNGGICVDGVNWFRCECAPGF-AGPDC 798
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 2-170 6.32e-69

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.95  E-value: 6.32e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531    2 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 81
Cdd:pfam07657    2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1768365531   82 AGAAGdrararsrtgghqDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 159
Cdd:pfam07657   80 LLKGS-------------FRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                          170
                   ....*....|.
gi 1768365531  160 HVAHLELQIRV 170
Cdd:pfam07657  147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
152-214 1.30e-24

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 97.79  E-value: 1.30e-24
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1768365531   152 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 214
Cdd:smart00051    1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 172-217 4.32e-18

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 78.82  E-value: 4.32e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1768365531  172 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 217
Cdd:pfam01414    1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
846-917 2.85e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 71.44  E-value: 2.85e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1768365531   846 CWSRGVSFPHGSSWVEDCNSCRCLDGHRDCSKVWCGWKPCLLspqpSALSAQCPPGQQCREKAMGqCLQPPC 917
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCGPKPCLL----HNLSGECPLGQGCVPSLSD-CLSSPC 67
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 801-837 1.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  801 NIDECQS-SPCAYGATCVDEINGYRCSCPPGRSGPRCQ 837
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 359-395 2.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  359 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 395
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 435-470 2.65e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.65e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1768365531  435 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 470
Cdd:cd00054      1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-319 6.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 6.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1768365531  281 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 319
Cdd:cd00054      1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-645 8.28e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  610 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 645
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
801-837 9.01e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.01e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   801 NIDECQS-SPCAYGATCVDEINGYRCSCPPG-RSGPRCQ 837
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
435-470 2.36e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.36e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   435 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGF-GGRHCE 470
Cdd:smart00179    1 DIDECasGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-432 8.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 8.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  397 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 432
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
610-641 1.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.02e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1768365531   610 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWE 641
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
359-395 1.08e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1768365531   359 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWV-GATCQ 395
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
281-319 1.29e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1768365531   281 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGY-LGKNCE 319
Cdd:smart00179    1 DIDECASGNPCQNGGTCVN-TVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 510-545 1.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1768365531  510 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 545
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 771-798 1.94e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.94e-04
                           10        20
                   ....*....|....*....|....*...
gi 1768365531  771 PCYNGGICVDGVNWFRCECAPGFAGPDC 798
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 731-761 2.41e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 2.41e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  731 PNPCVNGGTCVGSGDSFSCICRDGWEGRTCT 761
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-432 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 9.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1768365531   397 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWK-GANC 432
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 476-508 1.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1768365531  476 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 508
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 325-355 1.42e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  325 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 355
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 325-356 1.61e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1768365531  325 CAS-NPCANGGSCHEVLSGFECHCPSGWSGPTC 356
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 650-683 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1768365531  650 NDCL-PDPCHSRGRCYDLVNDFYCVCDDGWKGKTC 683
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 690-720 2.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.34e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  690 CDAYTCSNGGTCYDSGDTFRCACPPGWKGST 720
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 2.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.58e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  514 CEPNPCLNGARCYNLEDDYYCACPEDFGGKN 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-545 2.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1768365531   510 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDF-GGKNC 545
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-722 4.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.75e-03
                           10        20
                   ....*....|....*....|....*...
gi 1768365531  695 CSNGGTCYDSGDTFRCACPPGWKGSTCT 722
Cdd:cd00054     11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 443-464 5.22e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.39  E-value: 5.22e-03
                           10        20
                   ....*....|....*....|..
gi 1768365531  443 CQHGGTCKDLVNGYQCVCPRGF 464
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 767-797 5.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 5.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1768365531  767 CNPLPCYNGGICVDGVNWFRCECAPGFAGPD 797
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
771-798 7.66e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.66e-03
                            10        20
                    ....*....|....*....|....*....
gi 1768365531   771 PCYNGGICVDGVNWFRCECAPGF-AGPDC 798
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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