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Conserved domains on  [gi|17569343|ref|NP_510109|]
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BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
501-763 5.68e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.80  E-value: 5.68e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 501 MSAPRCSIGASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKM-KAERGRFDCTIHGGKVFAVAGSNGNND---- 575
Cdd:COG3055   9 LPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstp 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 576 LKSCEIYDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKLgteeaEWEPMASMEHPRY-QA 654
Cdd:COG3055  89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG-----TWTQLAPLPTPRDhLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 655 GVCTWKGLVVAAGGCDrwtcmdsveaFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTqsLDTVEILDSPSSQ 734
Cdd:COG3055 164 AAVLPDGKILVIGGRN----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNT 231

                       250       260
                ....*....|....*....|....*....
gi 17569343 735 WRVGPTLTTPRANtHAVVTAGNVIFCIGG 763
Cdd:COG3055 232 WTALGELPTPRHG-HAAVLTDGKVYVIGG 259
PHA03098 super family cl33709
kelch-like protein; Provisional
 183-735 9.36e-34

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 136.82  E-value: 9.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  183 DFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIV 262
Cdd:PHA03098  55 DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  263 DNFDSIVNDsKEFTQLPVIQVRIIVPAEDGKVTNNANnnggLAEMALFYFQNMPHDRAEHSIDLLTCkTHILYMEENHLA 342
Cdd:PHA03098 135 NNIELIYND-PDFIYLSKNELIKILSDDKLNVSSEDV----VLEIIIKWLTSKKNNKYKDICLILKV-LRITFLSEEGIK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  343 DCiemdERSSVGscdiIQDYKKSGKDRKDvakamtaqePIINSVVQHRVNGAvPVRLNASRLPNMNASNESLESAGTDDS 422
Cdd:PHA03098 209 KL----KRWKLR----IKKKKIVFNKRCI---------KIIYSKKYNLNKIL-PRSSTFGSIIYIHITMSIFTYNYITNY 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  423 DPQDTIEaRLISTHQtapqywvalvvlyrrlcvlslqltdneellrtkrepcpvdsqkaallsrlisctgkqqkplecms 502
Cdd:PHA03098 271 SPLSEIN-TIIDIHY----------------------------------------------------------------- 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  503 apRCSIGASFLNGKIFVCGGYD-RGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEI 581
Cdd:PHA03098 285 --VYCFGSVVLNNVIYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVES 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  582 YDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSF-DQKVLKDCERLDttklgTEEAEWEPMASMEHPRYQAGVCTWK 660
Cdd:PHA03098 363 WKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFS-----LNTNKWSKGSPLPISHYGGCAIYHD 437

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17569343  661 GLVVAAGG---CDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQW 735
Cdd:PHA03098 438 GKIYVIGGisyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 77-241 7.41e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18306:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 124  Bit Score: 114.66  E-value: 7.41e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEEnessqdeksptsssptnGHTNGITNgngev 156
Cdd:cd18306   2 PESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSD-----------------SDGESILT----- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 157 ahengapvsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLS 236
Cdd:cd18306  60 --------------------VKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119


                ....*
gi 17569343 237 NCIGI 241
Cdd:cd18306 120 NCIGI 124
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
501-763 5.68e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.80  E-value: 5.68e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 501 MSAPRCSIGASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKM-KAERGRFDCTIHGGKVFAVAGSNGNND---- 575
Cdd:COG3055   9 LPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstp 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 576 LKSCEIYDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKLgteeaEWEPMASMEHPRY-QA 654
Cdd:COG3055  89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG-----TWTQLAPLPTPRDhLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 655 GVCTWKGLVVAAGGCDrwtcmdsveaFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTqsLDTVEILDSPSSQ 734
Cdd:COG3055 164 AAVLPDGKILVIGGRN----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNT 231

                       250       260
                ....*....|....*....|....*....
gi 17569343 735 WRVGPTLTTPRANtHAVVTAGNVIFCIGG 763
Cdd:COG3055 232 WTALGELPTPRHG-HAAVLTDGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 183-735 9.36e-34

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 136.82  E-value: 9.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  183 DFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIV 262
Cdd:PHA03098  55 DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  263 DNFDSIVNDsKEFTQLPVIQVRIIVPAEDGKVTNNANnnggLAEMALFYFQNMPHDRAEHSIDLLTCkTHILYMEENHLA 342
Cdd:PHA03098 135 NNIELIYND-PDFIYLSKNELIKILSDDKLNVSSEDV----VLEIIIKWLTSKKNNKYKDICLILKV-LRITFLSEEGIK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  343 DCiemdERSSVGscdiIQDYKKSGKDRKDvakamtaqePIINSVVQHRVNGAvPVRLNASRLPNMNASNESLESAGTDDS 422
Cdd:PHA03098 209 KL----KRWKLR----IKKKKIVFNKRCI---------KIIYSKKYNLNKIL-PRSSTFGSIIYIHITMSIFTYNYITNY 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  423 DPQDTIEaRLISTHQtapqywvalvvlyrrlcvlslqltdneellrtkrepcpvdsqkaallsrlisctgkqqkplecms 502
Cdd:PHA03098 271 SPLSEIN-TIIDIHY----------------------------------------------------------------- 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  503 apRCSIGASFLNGKIFVCGGYD-RGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEI 581
Cdd:PHA03098 285 --VYCFGSVVLNNVIYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVES 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  582 YDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSF-DQKVLKDCERLDttklgTEEAEWEPMASMEHPRYQAGVCTWK 660
Cdd:PHA03098 363 WKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFS-----LNTNKWSKGSPLPISHYGGCAIYHD 437

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17569343  661 GLVVAAGG---CDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQW 735
Cdd:PHA03098 438 GKIYVIGGisyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-241 7.41e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 114.66  E-value: 7.41e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEEnessqdeksptsssptnGHTNGITNgngev 156
Cdd:cd18306   2 PESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSD-----------------SDGESILT----- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 157 ahengapvsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLS 236
Cdd:cd18306  60 --------------------VKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119


                ....*
gi 17569343 237 NCIGI 241
Cdd:cd18306 120 NCIGI 124
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 84-233 1.74e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.76  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343    84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEenessqdeksptsssptnghtngitngngevahengap 163
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSG-------------------------------------- 42

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   164 vsaqKPQKSSTTFYEFSQTDFECFEALVNFAYTANLeISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:pfam00651  43 ----QESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
PHA03098 PHA03098
kelch-like protein; Provisional
 637-790 1.90e-15

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  637 EEAEWEPMASmEHPRYQAGVCTWKGLVVAAGGCD-RWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGG 715
Cdd:PHA03098 272 PLSEINTIID-IHYVYCFGSVVLNNVIYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343  716 HDGTQSLDTVEILDSPSSQWRVGPTLTTPRANThAVVTAGNVIFCIGG-FNGVKFLDTIELLENEQIGWRNWQHCP 790
Cdd:PHA03098 351 IYNSISLNTVESWKPGESKWREEPPLIFPRYNP-CVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLP 425
Kelch smart00612
Kelch domain;
563-609 1.18e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.66  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17569343    563 KVFAVAGSNGNNDLKSCEIYDPKADVWAPLPNLATARCHNGCATIDN 609
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 237-335 1.30e-13

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 67.26  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 237 NCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVnDSKEFTQLPVIQVRIIVPAEDGKvtnNANNNGGLAEMALFYFQ-NM 315
Cdd:cd18502   5 NCIGIRSFAGRMNDSELLQKVDSYIQENIEEVA-ESKEFLKLPRLQIEVILESNQEL---ESINERKLCQLVLEWVQrSI 80

                        90       100
                ....*....|....*....|
gi 17569343 316 PHDraEHSIDLLTCKTHILY 335
Cdd:cd18502  81 EEG--GLDLDDLTEKVHMLY 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 95-233 4.31e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.79  E-value: 4.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343     95 DAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKsptsssptnghtngitngngevahengapvsaqkpqksst 174
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE---------------------------------------- 40

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 17569343    175 tfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:smart00225  41 --IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 504-549 3.09e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 3.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17569343   504 PRCSIGASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKMK 549
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 580-778 1.90e-05

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 47.48  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   580 EIYDPKADV-----WAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLdTTKLGTEEAEWEPMASMEHPrYQA 654
Cdd:TIGR03548  40 DIYTLKLDAnsalkWVKAGQLPYEIAYGASVSTPYGIYYVGGSPSSESFSDVLLL-SLDDTKEALIIETLPSLPVA-FDN 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   655 GVCTWK-GLVVAAGGCDRWTCMDSVEAFDPK--TNAWRQLPKLRQARRGGAVAVV-RDTLYVIGGHD--GTQSLDTVEIL 728
Cdd:TIGR03548 118 GSATYKdGKIYVGGGNANGKPSNKFYCLDLSndTSGWEELPEFPGEARVQPVCQAlHGKLYVFGGFQlgGDAIIYTDGYA 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17569343   729 DSPSS-QWRVGPTLTT----PRANT--HAVVTAGNVIFCIGGFNGVKFLDTIELLEN 778
Cdd:TIGR03548 198 YSPKTnTWQTVADPVLsdgePITLLggNSVKLGDSLMLVIGGVNYDIFFDAVDRLRQ 254
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 238-287 1.63e-03

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 38.68  E-value: 1.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   238 CIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNdSKEFTQLPVIQVRIIV 287
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAK-SEEFLELSLEQLLELL 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
501-763 5.68e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.80  E-value: 5.68e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 501 MSAPRCSIGASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKM-KAERGRFDCTIHGGKVFAVAGSNGNND---- 575
Cdd:COG3055   9 LPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstp 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 576 LKSCEIYDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKLgteeaEWEPMASMEHPRY-QA 654
Cdd:COG3055  89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG-----TWTQLAPLPTPRDhLA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 655 GVCTWKGLVVAAGGCDrwtcmdsveaFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTqsLDTVEILDSPSSQ 734
Cdd:COG3055 164 AAVLPDGKILVIGGRN----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNT 231

                       250       260
                ....*....|....*....|....*....
gi 17569343 735 WRVGPTLTTPRANtHAVVTAGNVIFCIGG 763
Cdd:COG3055 232 WTALGELPTPRHG-HAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
509-729 2.01e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.53  E-value: 2.01e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 509 GASFLNGKIFVCGGYD----RGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDP 584
Cdd:COG3055  65 AAVAQDGKLYVFGGFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDP 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 585 KADVWAPLPNLATARCHNGCATI-DNYVYCIGGsfdqkvlkdceRLDTTKLGTeeaeWEPMASMEHPRYQAGVCTWKGLV 663
Cdd:COG3055 145 ATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGG-----------RNGSGFSNT----WTTLAPLPTARAGHAAAVLGGKI 209

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 664 VAAGGCDRWTcmDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHD----GTQSLDTVEILD 729
Cdd:COG3055 210 LVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
542-776 9.27e-35

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 133.74  E-value: 9.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 542 WRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDPKADVWAPLPNLAT-ARCHNGCATIDNYVYCIGG---- 616
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftga 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 617 SFDQKVLKDCERLDTTKlgteeAEWEPMASMEHPRYQAGVCTWKGLVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLRQ 696
Cdd:COG3055  83 NPSSTPLNDVYVYDPAT-----NTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 697 ARRGGAVAVVRD-TLYVIGGHDGTQSLDTveildspssqWRVGPTLTTPRANtHAVVTAGNVIFCIGGFNGvkFLDTIEL 775
Cdd:COG3055 158 PRDHLAAAVLPDgKILVIGGRNGSGFSNT----------WTTLAPLPTARAG-HAAAVLGGKILVFGGESG--FSDEVEA 224


                .
gi 17569343 776 L 776
Cdd:COG3055 225 Y 225
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
589-778 1.07e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 133.74  E-value: 1.07e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 589 WAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKlgteeAEWEPMASM-EHPRYQAGVCTWKGLVVAAG 667
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPAT-----NTWSELAPLpGPPRHHAAAVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 668 GCD----RWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQWRVGPTLTT 743
Cdd:COG3055  78 GFTganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17569343 744 PRANTHAVVTAGNVIFCIGGFNGVKFLDTIELLEN 778
Cdd:COG3055 158 PRDHLAAAVLPDGKILVIGGRNGSGFSNTWTTLAP 192
PHA03098 PHA03098
kelch-like protein; Provisional
 183-735 9.36e-34

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 136.82  E-value: 9.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  183 DFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIV 262
Cdd:PHA03098  55 DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  263 DNFDSIVNDsKEFTQLPVIQVRIIVPAEDGKVTNNANnnggLAEMALFYFQNMPHDRAEHSIDLLTCkTHILYMEENHLA 342
Cdd:PHA03098 135 NNIELIYND-PDFIYLSKNELIKILSDDKLNVSSEDV----VLEIIIKWLTSKKNNKYKDICLILKV-LRITFLSEEGIK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  343 DCiemdERSSVGscdiIQDYKKSGKDRKDvakamtaqePIINSVVQHRVNGAvPVRLNASRLPNMNASNESLESAGTDDS 422
Cdd:PHA03098 209 KL----KRWKLR----IKKKKIVFNKRCI---------KIIYSKKYNLNKIL-PRSSTFGSIIYIHITMSIFTYNYITNY 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  423 DPQDTIEaRLISTHQtapqywvalvvlyrrlcvlslqltdneellrtkrepcpvdsqkaallsrlisctgkqqkplecms 502
Cdd:PHA03098 271 SPLSEIN-TIIDIHY----------------------------------------------------------------- 284

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  503 apRCSIGASFLNGKIFVCGGYD-RGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEI 581
Cdd:PHA03098 285 --VYCFGSVVLNNVIYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVES 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  582 YDPKADVWAPLPNLATARCHNGCATIDNYVYCIGGSF-DQKVLKDCERLDttklgTEEAEWEPMASMEHPRYQAGVCTWK 660
Cdd:PHA03098 363 WKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFS-----LNTNKWSKGSPLPISHYGGCAIYHD 437

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17569343  661 GLVVAAGG---CDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQW 735
Cdd:PHA03098 438 GKIYVIGGisyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-241 7.41e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 114.66  E-value: 7.41e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEEnessqdeksptsssptnGHTNGITNgngev 156
Cdd:cd18306   2 PESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSD-----------------SDGESILT----- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 157 ahengapvsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLS 236
Cdd:cd18306  60 --------------------VKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119


                ....*
gi 17569343 237 NCIGI 241
Cdd:cd18306 120 NCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
639-784 2.18e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 101.00  E-value: 2.18e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 639 AEWEPMASMEHPRYQAGVCTWKGLVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVV-RDTLYVIGG-- 715
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGft 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17569343 716 --HDGTQSLDTVEILDSPSSQWRVGPTLTTPRANtHAVVTAGNVIFCIGGFNGVKFLDTIELLENEQIGWR 784
Cdd:COG3055  81 gaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGG-ATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT 150
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-240 3.39e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 78.10  E-value: 3.39e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEE-NESSQDeksptsssptnghtngitngngeva 157
Cdd:cd18238   1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmAESKQD------------------------- 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 hengapvsaqkpqksSTTFYEFsqtDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18238  56 ---------------SITIKDI---DEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSN 117


                ...
gi 17569343 238 CIG 240
Cdd:cd18238 118 CLG 120
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-240 7.06e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 77.53  E-value: 7.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeenessqdeksptsssptnghTNGITNGNGEVah 158
Cdd:cd18237   7 DFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFT---------------------SNMTESKSSEV-- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 159 engapvsaqkpqkssttfyEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18237  64 -------------------ELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNC 124


                ..
gi 17569343 239 IG 240
Cdd:cd18237 125 LG 126
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 84-233 1.74e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 75.76  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343    84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEenessqdeksptsssptnghtngitngngevahengap 163
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSG-------------------------------------- 42

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   164 vsaqKPQKSSTTFYEFSQTDFECFEALVNFAYTANLeISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:pfam00651  43 ----QESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
PHA03098 PHA03098
kelch-like protein; Provisional
 637-790 1.90e-15

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  637 EEAEWEPMASmEHPRYQAGVCTWKGLVVAAGGCD-RWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGG 715
Cdd:PHA03098 272 PLSEINTIID-IHYVYCFGSVVLNNVIYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343  716 HDGTQSLDTVEILDSPSSQWRVGPTLTTPRANThAVVTAGNVIFCIGG-FNGVKFLDTIELLENEQIGWRNWQHCP 790
Cdd:PHA03098 351 IYNSISLNTVESWKPGESKWREEPPLIFPRYNP-CVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLP 425
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-240 7.64e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 71.71  E-value: 7.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEE-NESSQDEksptsssptnghtngitngngeva 157
Cdd:cd18249   9 QTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTE------------------------ 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 hengapvsaqkpqkssTTFYEFsqtDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18249  65 ----------------VTIRDI---DERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSN 125


                ...
gi 17569343 238 CIG 240
Cdd:cd18249 126 CLG 128
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 71-241 2.95e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 70.62  E-value: 2.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  71 LRDPSIKNDLLDRLNTFRRNRELCDAVLFV--------KEREIFVHKVVLAAVSPALLDMFneenessqdeksptssspt 142
Cdd:cd18273   4 LEDAAHARALLAQLKSFYDARLLTDVTIEVngpgsgpgSGRLFPCNRNVLAAASPYFKSMF------------------- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 143 nghtngiTNGNGEvahengapvSAQKpqksSTTFYEfsqTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVI 222
Cdd:cd18273  65 -------TGGLYE---------SKQE----TVTIHD---VDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVR 121

                       170
                ....*....|....*....
gi 17569343 223 RACAAYLAENLQLSNCIGI 241
Cdd:cd18273 122 EACASFLARRLDLSNCVGI 140
Kelch smart00612
Kelch domain;
563-609 1.18e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.66  E-value: 1.18e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17569343    563 KVFAVAGSNGNNDLKSCEIYDPKADVWAPLPNLATARCHNGCATIDN 609
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 237-335 1.30e-13

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 67.26  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 237 NCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVnDSKEFTQLPVIQVRIIVPAEDGKvtnNANNNGGLAEMALFYFQ-NM 315
Cdd:cd18502   5 NCIGIRSFAGRMNDSELLQKVDSYIQENIEEVA-ESKEFLKLPRLQIEVILESNQEL---ESINERKLCQLVLEWVQrSI 80

                        90       100
                ....*....|....*....|
gi 17569343 316 PHDraEHSIDLLTCKTHILY 335
Cdd:cd18502  81 EEG--GLDLDDLTEKVHMLY 98
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-231 3.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 66.92  E-value: 3.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  83 RLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEKsptsssptngHTNGItngngevaheng 161
Cdd:cd18247   9 VMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFtHDMVESKQDEI----------TMQGI------------ 66

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 162 apvsaqkpqkssttfyefsqtDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAE 231
Cdd:cd18247  67 ---------------------EPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 95-233 4.31e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.79  E-value: 4.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343     95 DAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKsptsssptnghtngitngngevahengapvsaqkpqksst 174
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE---------------------------------------- 40

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 17569343    175 tfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:smart00225  41 --IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-233 6.61e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 66.02  E-value: 6.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeeNESSQDEKSptsssptnghtngitngngEVahe 159
Cdd:cd18257   5 LLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFT--GNLSEKENS-------------------EV--- 60

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569343 160 ngapvsaqkpqkssttfyEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18257  61 ------------------EFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
Kelch smart00612
Kelch domain;
710-755 6.89e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.35  E-value: 6.89e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 17569343    710 LYVIGGHDGTQSLDTVEILDSPSSQWRVGPTLTTPRANTHAVVTAG 755
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-238 7.14e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 65.93  E-value: 7.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEKSPTSSSPtnghtngitngngeva 157
Cdd:cd18242   7 SILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtSEMSEKGKSEVELQGLTA---------------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 hengapvsaqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18242  71 ---------------------------STMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123


                .
gi 17569343 238 C 238
Cdd:cd18242 124 C 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-216 1.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 64.11  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  93 LCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKsptsssptnghtngitngngevahengapvsaqkpqks 172
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-------------------------------------- 42

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17569343 173 sttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYAL 216
Cdd:cd18186  43 ----IELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
Kelch smart00612
Kelch domain;
516-562 1.74e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.19  E-value: 1.74e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17569343    516 KIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGG 562
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 504-549 3.09e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.47  E-value: 3.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17569343   504 PRCSIGASFLNGKIFVCGGYDRGECLRSVEEYDVVNGKWRNVAKMK 549
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-240 5.70e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 63.58  E-value: 5.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEE-NESSQDEksptsssptnghtngitngngevah 158
Cdd:cd18256   7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGmSESSKDV------------------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 159 engapVSAQKPQKSSttfyefsqtdfecFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18256  62 -----VQIHGVEPDI-------------FHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNC 123


                ..
gi 17569343 239 IG 240
Cdd:cd18256 124 IG 125
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-242 7.46e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 63.14  E-value: 7.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  83 RLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEksptsssptnghtngitngngevaheng 161
Cdd:cd18336   9 KMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFtNDVREAKQEE---------------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 162 apvsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGI 241
Cdd:cd18336  61 ---------------IKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125


                .
gi 17569343 242 R 242
Cdd:cd18336 126 R 126
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 650-695 7.90e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 60.32  E-value: 7.90e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17569343   650 PRYQAGVCTWKGLVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLR 695
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-240 8.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 63.31  E-value: 8.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  73 DPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIF-VHKVVLAAVSPALLDMFneenessqdeksptsssptnghtngitn 151
Cdd:cd18252   1 DSSHPADFLDAFRTFYLDGLFTDITLQCASGQIFhCHKAALAACSSYFKVMF---------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 152 gngevahengapvSAQKPQKSSTTFyEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAE 231
Cdd:cd18252  53 -------------TADMKEKSNNVI-KLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVR 118


                ....*....
gi 17569343 232 NLQLSNCIG 240
Cdd:cd18252 119 HLDIDNCLG 127
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-239 1.57e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 61.61  E-value: 1.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  93 LCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEksptsssptnghtngitngngevahengapvsaqkpqk 171
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFtNDVREATEEE-------------------------------------- 42

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17569343 172 ssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCI 239
Cdd:cd18234  43 -----IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-238 1.66e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 61.96  E-value: 1.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneenessqdeksptsssptnghTNGITNGNGEVAHENGap 163
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALF----------------------TNGWNETEKKVYKIPG-- 63

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17569343 164 VSAqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18240  64 VSP------------------EMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-240 1.91e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 62.54  E-value: 1.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeenessqdeksptsssptnghtngitngn 153
Cdd:cd18259  13 PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFT----------------------------- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 154 GEVAHENGAPVsaqkpqkssttfyEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18259  64 GDFVESISARV-------------EIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQI 130


                ....*..
gi 17569343 234 QLSNCIG 240
Cdd:cd18259 131 DATNCLG 137
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-233 2.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 61.63  E-value: 2.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  84 LNTFRRNRELCDAVLFVK----EREIFVHKVVLAAVSPALLDMFneenessqdeksptsssptnghtngiTNGNGEvAHE 159
Cdd:cd18248  12 MNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMF--------------------------TSGLRE-CGM 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569343 160 NGAPVSAQKPQkssttfyefsqtdfeCFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18248  65 EVVPIEGVHPC---------------VMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-241 2.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 61.73  E-value: 2.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  72 RDPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEKsptsssptngHTNGIt 150
Cdd:cd18268   2 KDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFcNNFRESSQAKV----------DLKGI- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 151 ngngevahengapvsaqkpqkssttfyefsqtDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLA 230
Cdd:cd18268  71 --------------------------------DSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQ 118

                       170
                ....*....|.
gi 17569343 231 ENLQLSNCIGI 241
Cdd:cd18268 119 DQLTPENCLSM 129
Kelch smart00612
Kelch domain;
662-708 3.43e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 58.72  E-value: 3.43e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17569343    662 LVVAAGGCDRWTCMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRD 708
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-238 3.57e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 61.26  E-value: 3.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDaVLFVKEREIF-VHKVVLAAVSPALLDMFNEE-NESSQDEKSptsssptnghtngiTNGngeva 157
Cdd:cd18255   5 LLQGLNALRAKGQLLD-VTLIADGQRFqAHKVVLASCSDYFRAMFTGGmRESSQDEIE--------------LKG----- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 hengapVSAQKPQKssttfyefsqtdfecfeaLVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18255  65 ------VSAKGLKH------------------ILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120


                .
gi 17569343 238 C 238
Cdd:cd18255 121 C 121
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 697-742 4.63e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 4.63e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17569343   697 ARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQWRVGPTLT 742
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-229 6.02e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 60.05  E-value: 6.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeenesSQDEKSPTSSSPTNghTNGITngngevahe 159
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLN-----YNPPKDDGSTYKIE--LEGIS--------- 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 160 ngapvsaqkpqkssttfyefsqtdFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18245  65 ------------------------VEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-238 1.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 59.78  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  73 DPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKSptsssptnghtngitng 152
Cdd:cd18250   1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRV----------------- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 153 ngeVAHEngapVSAqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAEN 232
Cdd:cd18250  64 ---VLHG----VSA------------------EILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQR 118


                ....*.
gi 17569343 233 LQLSNC 238
Cdd:cd18250 119 LDVSNC 124
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-233 1.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 58.98  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFN-EENESsqdeksptsssptngHTNGITngnge 155
Cdd:cd18235   5 TQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTgDLSES---------------RANRVT----- 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17569343 156 vahengapvsaqkpqkssttfyeFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18235  65 -----------------------LQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-233 2.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 59.10  E-value: 2.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneeneSSQDEKSPTSSSPTNGHTngitngngevah 158
Cdd:cd18228   5 ELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKL-----VGQASPRLVLVSPAGKCV------------ 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17569343 159 engapvsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18228  68 ------------------LDLHHVTVTGFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-242 5.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 58.15  E-value: 5.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  83 RLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQDEKSPTSSSPTnghtngitngngevaheng 161
Cdd:cd18337  13 KMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFtNDVREAKQEEIKMEGVEPN------------------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 162 apvsaqkpqkssttfyefsqtdfeCFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGI 241
Cdd:cd18337  74 ------------------------ALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129


                .
gi 17569343 242 R 242
Cdd:cd18337 130 R 130
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-241 6.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 57.89  E-value: 6.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLfVKEREIF-VHKVVLAAVSPALLDMFN-EENESSQDEKsptsssptnghtngitngngeVA 157
Cdd:cd18276   8 LLDQLNRMKELAELTDVVL-VAEGEKFpCHRLVLAAFSPYFKAMFTcGLMECSQREV---------------------VL 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 HENGAPVSAqkpqkssttfyefsqtdfecfeALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18276  66 HDITAESVS----------------------IILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASN 123


                ....
gi 17569343 238 CIGI 241
Cdd:cd18276 124 CLGI 127
PHA02790 PHA02790
Kelch-like protein; Provisional
 611-786 6.89e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 62.37  E-value: 6.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  611 VYCIGGSFDQKVLKDCERLDTTklgteEAEWEPMASMEHPR-YQAGVCTWKGLVVAaGGCDRWTcmdSVEAFDPKTNAWR 689
Cdd:PHA02790 274 VYLIGGWMNNEIHNNAIAVNYI-----SNNWIPIPPMNSPRlYASGVPANNKLYVV-GGLPNPT---SVERWFHGDAAWV 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  690 QLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSldTVEILDSPSSQWRVGPTLTTPRANTHAVV----------------- 752
Cdd:PHA02790 345 NMPSLLKPRCNPAVASINNVIYVIGGHSETDT--TTEYLLPNHDQWQFGPSTYYPHYKSCALVfgrrlflvgrnaefyce 422

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17569343  753 ---------------------TAGNVIFCIGGFNGVKFLDTIELLENEQIGWRNW 786
Cdd:PHA02790 423 ssntwtliddpiyprdnpeliIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNIW 477
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 238-344 2.01e-09

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 55.43  E-value: 2.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343    238 CIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNdSKEFTQLPVIQVRIIVPAEDGKVTNNANnnggLAEMALFYFQNMPH 317
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSS-SEEFLELPLEQLLELLSSDDLNVSSEEE----VFEAVLRWVKHDPE 75

                           90       100
                   ....*....|....*....|....*..
gi 17569343    318 DRAEHSIDLLTCkTHILYMEENHLADC 344
Cdd:smart00875  76 KRREHLPELLEH-VRLPLLSPDYLLEV 101
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-239 2.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 56.55  E-value: 2.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneenessqdeksptsssptnghTNGITngngevahe 159
Cdd:cd18270  13 LLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMF----------------------MSGLS--------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 160 ngapvsaqkpqKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCI 239
Cdd:cd18270  62 -----------ESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-234 6.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 54.73  E-value: 6.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKsptsssptnghtngitngngevahengap 163
Cdd:cd18339  12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK----------------------------- 62

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17569343 164 vsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQ 234
Cdd:cd18339  63 -------------IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLH 120
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-229 1.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 53.79  E-value: 1.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeenessqdeksptsssptnghtngitngn 153
Cdd:cd18326   6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFT----------------------------- 56

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 154 gevaheNGAPVSAQkpqksstTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18326  57 ------SGAVVDQQ-------NVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 552-595 2.76e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 50.30  E-value: 2.76e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 17569343   552 RGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDPKADVWAPLPNL 595
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-238 3.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 52.53  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneenessqdeksptssspTNGHtngitngngevah 158
Cdd:cd18253   4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMF------------------CNDH------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 159 engapvsaqkpQKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18253  53 -----------RESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-240 3.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 52.71  E-value: 3.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDeksptssSPTNGHTNgitngn 153
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLD-------STVNFHDS------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 154 gevAHEngapvsaqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18254  70 ---LHP-------------------------EVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 121


                ....*..
gi 17569343 234 QLSNCIG 240
Cdd:cd18254 122 YPSNCLG 128
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-229 4.76e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 52.15  E-value: 4.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENessqdeksptsssptnGHTNGITNGN 153
Cdd:cd18327   6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGG----------------GGSGDLGAGG 69

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17569343 154 GEvahengapvsaqkpqkssttfyEFSQTDF---ECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18327  70 GQ----------------------DVCELDFvgpEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 83-242 6.76e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 51.97  E-value: 6.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  83 RLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEksptsssptnghtngitngngEVAHENGA 162
Cdd:cd18335   9 KMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQE---------------------EIKMEGID 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 163 PvsaqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGIR 242
Cdd:cd18335  68 P---------------------NALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 235-287 8.78e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 49.20  E-value: 8.78e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17569343 235 LSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNdSKEFTQLPVIQVRIIV 287
Cdd:cd14733   2 PENCLGILELADLYNLEELKEKALKFILENFEEVSK-SEEFLELSVELLLELL 53
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-241 1.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 51.37  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFnEENESSQDEKSPTsssptnghtngITNGNGEVAHe 159
Cdd:cd18271  11 ILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMF-EVNMKERDDGSVT-----------ISNLSPKAVK- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 160 ngapvsaqkpqkssttfyefsqtdfecfeALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCI 239
Cdd:cd18271  78 -----------------------------AFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128


                ..
gi 17569343 240 GI 241
Cdd:cd18271 129 QL 130
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-241 1.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 51.53  E-value: 1.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  70 MLRDPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDeksptssSPTNGHtngi 149
Cdd:cd18267  17 LFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQD-------SEVNFH---- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 150 tngngevahengapvSAQKPqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18267  86 ---------------DSIHP---------------EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFL 135

                       170
                ....*....|..
gi 17569343 230 AENLQLSNCIGI 241
Cdd:cd18267 136 EKNLHPTNCLGM 147
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-229 1.97e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 50.25  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEenessqdeksptsssptnghtngitngn 153
Cdd:cd18198   6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS---------------------------- 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 154 gevahenGAPVSAQkpqksstTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18198  58 -------GAVVDQQ-------NVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-240 2.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 50.36  E-value: 2.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEeneSSQDEksptsssptnghtngitnGNGEVAH 158
Cdd:cd18258   3 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKR---SSRDS------------------GGGEKLE 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 159 ENGAPVSAqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18258  62 LTMSNINA------------------DVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNC 123


                ..
gi 17569343 239 IG 240
Cdd:cd18258 124 LG 125
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 598-647 2.29e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 2.29e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   598 ARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDttklgTEEAEWEPMASM 647
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYD-----PETNTWSKLPSM 45
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-240 2.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 50.23  E-value: 2.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKSptsssptnghtngITNGngevahe 159
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKI-------------IIKG------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 160 ngapvsaqkpqkssttfyefsqTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCI 239
Cdd:cd18236  71 ----------------------VDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCV 128


                .
gi 17569343 240 G 240
Cdd:cd18236 129 G 129
PHA02713 PHA02713
hypothetical protein; Provisional
 510-617 2.66e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 54.25  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  510 ASFLNGKIFVCGGYD-RGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDPKADV 588
Cdd:PHA02713 299 SAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDK 378

                         90       100
                 ....*....|....*....|....*....
gi 17569343  589 WAPLPNLATARCHNGCATIDNYVYCIGGS 617
Cdd:PHA02713 379 WKMLPDMPIALSSYGMCVLDQYIYIIGGR 407
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-233 2.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 50.41  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF-NEENESSQdeksptsssptnghtngitngngevahenga 162
Cdd:cd18246  30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFtNEMSESRQ------------------------------- 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17569343 163 pvsaqkpqksstTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18246  79 ------------THVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-225 3.77e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 49.49  E-value: 3.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQdeksptsssptnghtngitngn 153
Cdd:cd18328   6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQ---------------------- 63

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17569343 154 gevahengapvsaqkpqkssTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRAC 225
Cdd:cd18328  64 --------------------PYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-225 7.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 48.60  E-value: 7.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSpallDMFNEENESSQDEksptsssptnghtngitngngevahe 159
Cdd:cd18217   5 LLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFS----EYFGAQYKDTEDN-------------------------- 54

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 160 ngapvsaqkpqkssTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRAC 225
Cdd:cd18217  55 --------------IVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 79-241 7.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 48.94  E-value: 7.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  79 DLLDRlNTFrrnrelCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQdeksptsssptnghtngitngNGEVAH 158
Cdd:cd18269  20 DLLDE-NKF------VDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESK---------------------KKEVVL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 159 ENGAPvsaqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNC 238
Cdd:cd18269  72 EDVDP---------------------DVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNC 130


                ...
gi 17569343 239 IGI 241
Cdd:cd18269 131 LAI 133
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-239 1.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 48.25  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  66 AYTLMLRDpSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneenessqdeKSPTSSSPTNgh 145
Cdd:cd18264   2 SYFLAYSK-SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALF----------KDYTQESKAR-- 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 146 tngitngngeVAHengapvsaqKPQKSSTTFyefsqtdfecfEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRAC 225
Cdd:cd18264  69 ----------VIH---------LPVVSAAGL-----------QRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLC 118

                       170
                ....*....|....
gi 17569343 226 AAYLAENLQLSNCI 239
Cdd:cd18264 119 SQYLINNLAPENCC 132
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-234 1.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 47.76  E-value: 1.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  84 LNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKsptsssptnghtngitngngevahengap 163
Cdd:cd18338  12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKR----------------------------- 62

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17569343 164 vsaqkpqkssttfYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQ 234
Cdd:cd18338  63 -------------VRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLH 120
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-225 2.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 47.54  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNeenessqdEKSPTSSsptnghtngitngngevaHE 159
Cdd:cd18202   6 VLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFI--------EKGAVSS------------------HE 59

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 160 ngAPVSAQKPQKSSttfyefsqtdfecFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRAC 225
Cdd:cd18202  60 --AVVDLSGFCKSS-------------FLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
PHA02790 PHA02790
Kelch-like protein; Provisional
 517-737 4.46e-06

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 50.04  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  517 IFVCGGYDRGECLRSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNgnnDLKSCEIYDPKADVWAPLPNLA 596
Cdd:PHA02790 274 VYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLP---NPTSVERWFHGDAAWVNMPSLL 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  597 TARCHNGCATIDNYVYCIGGSfdqkvlkdcERLDTTK--LGTEEAEWEPMASMEHPRYQAGVCTWKGLVVAAGGCDRWTC 674
Cdd:PHA02790 351 KPRCNPAVASINNVIYVIGGH---------SETDTTTeyLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNAEFYC 421

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17569343  675 MDSveafdpktNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQWRV 737
Cdd:PHA02790 422 ESS--------NTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-128 9.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 45.59  E-value: 9.43e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17569343  78 NDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF--NEENE 128
Cdd:cd18214  10 DSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFllNDSRE 62
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 236-275 1.03e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 44.60  E-value: 1.03e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17569343 236 SNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVnDSKEF 275
Cdd:cd18448   5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVV-ECEEF 43
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-236 1.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 45.44  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQdeksptsssptnghtngitngN 153
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSD---------------------Q 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 154 GEVAHENgaPVSAQKpqkssttfyefsqtdfecFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18230  61 ATVTHLD--IVTAQG------------------FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120


                ...
gi 17569343 234 QLS 236
Cdd:cd18230 121 DIS 123
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 580-778 1.90e-05

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 47.48  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   580 EIYDPKADV-----WAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLdTTKLGTEEAEWEPMASMEHPrYQA 654
Cdd:TIGR03548  40 DIYTLKLDAnsalkWVKAGQLPYEIAYGASVSTPYGIYYVGGSPSSESFSDVLLL-SLDDTKEALIIETLPSLPVA-FDN 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343   655 GVCTWK-GLVVAAGGCDRWTCMDSVEAFDPK--TNAWRQLPKLRQARRGGAVAVV-RDTLYVIGGHD--GTQSLDTVEIL 728
Cdd:TIGR03548 118 GSATYKdGKIYVGGGNANGKPSNKFYCLDLSndTSGWEELPEFPGEARVQPVCQAlHGKLYVFGGFQlgGDAIIYTDGYA 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17569343   729 DSPSS-QWRVGPTLTT----PRANT--HAVVTAGNVIFCIGGFNGVKFLDTIELLEN 778
Cdd:TIGR03548 198 YSPKTnTWQTVADPVLsdgePITLLggNSVKLGDSLMLVIGGVNYDIFFDAVDRLRQ 254
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-229 1.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAvSPALLDMFNEENessqdeksptsssptnghtngitngngevAHE 159
Cdd:cd18329   8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFA-SSGYFKMLLSQN-----------------------------AKE 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 160 NGAPVSAqkpqksstTFYEFSQtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18329  58 TGQPTVA--------TFDVFSP---DTFTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
PLN02153 PLN02153
epithiospecifier protein
 504-763 3.93e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 3.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  504 PRCSIGASFLNGKIFVCGG--YDRGECLRSVEEYDVVNGKWrNVAKMKAERGRFDC-----TIHGGKVFAVAGSNGNNDL 576
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTW-SIAPANGDVPRISClgvrmVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  577 KSCEIYDPKADVWAPLPNL-----ATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTtklgteeaewepmasmehpr 651
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT-------------------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  652 yqagvctwkglvvaaggcdrwtcmdsVEAFDPKTNAWRQLPKLRQ--ARRGGA-VAVVRDTLYVI---------GGHDGT 719
Cdd:PLN02153 161 --------------------------IEAYNIADGKWVQLPDPGEnfEKRGGAgFAVVQGKIWVVygfatsilpGGKSDY 214

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 17569343  720 QSlDTVEILDSPSSQW-RVGPTLTTPRANT---HAVVtaGNVIFCIGG 763
Cdd:PLN02153 215 ES-NAVQFFDPASGKWtEVETTGAKPSARSvfaHAVV--GKYIIIFGG 259
Kelch_6 pfam13964
Kelch motif;
598-651 6.06e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 6.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343   598 ARCHNGCATIDNYVYCIGGSFDQ-KVLKDCERLDT-TKlgteeaEWEPMASMEHPR 651
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPlTK------SWEELPPLPTPR 50
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-228 7.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 42.86  E-value: 7.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDeksptsssptnghtngITNGNGEV 156
Cdd:cd18212   7 KDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQS----------------IYMLEGMV 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17569343 157 AhengapvsaqkpqkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAY 228
Cdd:cd18212  71 A---------------------------ETFGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-121 8.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 43.11  E-value: 8.41e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17569343  69 LMLRDPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLD 121
Cdd:cd18222   1 IQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRD 53
Kelch_6 pfam13964
Kelch motif;
697-745 9.72e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 9.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   697 ARRGGAVAVVRDTLYVIGG-HDGTQSLDTVEILDSPSSQWRVGPTLTTPR 745
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-133 1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 42.27  E-value: 1.11e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17569343  77 KNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEEN--ESSQDE 133
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSE 59
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 233-295 1.27e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 42.07  E-value: 1.27e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17569343 233 LQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNdSKEFTQLPVIQVRIIVPAEDGKVT 295
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLN-HEEFLELPVDILCHILKSDDLYVT 62
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 233-287 1.28e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 41.06  E-value: 1.28e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17569343 233 LQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNDSKEFTQLPVIQVRIIV 287
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDSEEFLELSCEELEDII 55
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-229 1.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 41.93  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDmfneenessqdeksptsssptnghtngitngN 153
Cdd:cd18220   6 PEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRD-------------------------------H 54

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 154 GEVAHENGAPVSAQKPQkssttfyefsqtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18220  55 SALSTMSGLSISVIKNP--------------NVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-130 2.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 41.36  E-value: 2.34e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESS 130
Cdd:cd18210   2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSS 58
Kelch smart00612
Kelch domain;
611-658 2.52e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 2.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 17569343    611 VYCIGGSFDQKVLKDCERLDTtklgtEEAEWEPMASMEHPRYQAGVCT 658
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDP-----ETNKWTPLPSMPTPRSGHGVAV 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 744-774 2.92e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 2.92e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 17569343   744 PRANtHAVVTAGNVIFCIGGFNGVKFLDTIE 774
Cdd:pfam01344   1 RRSG-AGVVVVGGKIYVIGGFDGNQSLNSVE 30
Kelch_6 pfam13964
Kelch motif;
650-698 4.74e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.47  E-value: 4.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   650 PRYQAGVCTWKGLVVAAGG-CDRWTCMDSVEAFDPKTNAWRQLPKLRQAR 698
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-237 5.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 41.03  E-value: 5.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  78 NDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFneenessqdeksptsssptnghtngiTNGNGEvA 157
Cdd:cd18266  10 NLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF--------------------------TIGMRE-A 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343 158 HENGApvsaqkpqkssttfyEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSN 237
Cdd:cd18266  63 HQKEV---------------ELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 93-132 5.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 39.46  E-value: 5.33e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 17569343  93 LCDAVLFVKEREIFVHKVVLAAVSPALLDMFnEENESSQD 132
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEH 39
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-130 6.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 40.41  E-value: 6.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17569343  68 TLMLRDPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESS 130
Cdd:cd18290   2 TLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAV 64
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-131 6.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 39.86  E-value: 6.91e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQ 131
Cdd:cd18209   5 LLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQ 56
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-233 1.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 39.55  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEKSptsssptnghtngitngngeVAHE 159
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTT--------------------VTHL 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569343 160 NGAPVSAqkpqkssttfyefsqtdfecFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENL 233
Cdd:cd18201  68 DVVAVQG--------------------FSVILDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-121 1.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 39.54  E-value: 1.40e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 17569343  74 PSIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLD 121
Cdd:cd18227   6 PDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCD 53
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-134 1.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 39.60  E-value: 1.40e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQDEK 134
Cdd:cd18343   8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNR 62
PLN02193 PLN02193
nitrile-specifier protein
 497-642 1.53e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.86  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  497 PLECMSAPRC--SIGASFLNgkIFVCGGYDRGECLRSVEEYDVVNGKW---RNVAKMKAERGRFDCTIHGGKVFAVAGSN 571
Cdd:PLN02193 261 PVEEGPTPRSfhSMAADEEN--VYVFGGVSATARLKTLDSYNIVDKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFN 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  572 GnndlksCEI-----YDPKADVWAPLPNLA---TARCHNGCATIDNYVYCIGG--SFDQKVLKDCERL--DTTKLGTEEA 639
Cdd:PLN02193 339 G------CEVddvhyYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIVIFGGeiAMDPLAHVGPGQLtdGTFALDTETL 412


                 ...
gi 17569343  640 EWE 642
Cdd:PLN02193 413 QWE 415
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 238-287 1.63e-03

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 38.68  E-value: 1.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   238 CIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNdSKEFTQLPVIQVRIIV 287
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAK-SEEFLELSLEQLLELL 49
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 236-291 2.17e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 38.75  E-value: 2.17e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17569343 236 SNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVnDSKEFTQLPVIQVRIIVPAED 291
Cdd:cd18445   4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVV-KGEEFLLLSKEQVCELISSDD 58
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-229 2.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 38.56  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVS---PALLDMFneenessqdeksptsssptnghtngitngngev 156
Cdd:cd18199   5 LLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSgyfRMLLSHY--------------------------------- 51

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17569343 157 AHENGAPVSAqkpqksstTFYEFSQtdfECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYL 229
Cdd:cd18199  52 IQDTGRPSTA--------SFDVFSS---DAFSIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
PHA02713 PHA02713
hypothetical protein; Provisional
 690-781 2.39e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.53  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569343  690 QLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQWRVGPTLttPRA-NTHAVVTAGNVIFCIGG----- 763
Cdd:PHA02713 334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDM--PIAlSSYGMCVLDQYIYIIGGrtehi 411

                         90
                 ....*....|....*....
gi 17569343  764 -FNGVKFLDTIELLENEQI 781
Cdd:PHA02713 412 dYTSVHHMNSIDMEEDTHS 430
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 233-291 2.87e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 37.79  E-value: 2.87e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17569343 233 LQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVnDSKEFTQLPVIQVRIIVPAED 291
Cdd:cd18459   2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVM-ESEEFMLLPVNQLIDIISSDE 59
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-131 3.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 38.28  E-value: 3.00e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESSQ 131
Cdd:cd18279   5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESK 56
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 90-130 3.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 37.71  E-value: 3.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 17569343  90 NRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEENESS 130
Cdd:cd18314   3 DSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIES 43
Kelch_6 pfam13964
Kelch motif;
504-552 3.50e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 3.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17569343   504 PRCSIGASFLNGKIFVCGGY-DRGECLRSVEEYDVVNGKWRNVAKMKAER 552
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-123 3.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 37.93  E-value: 3.53e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMF 123
Cdd:cd18197  12 VLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQF 55
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-121 4.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.91  E-value: 4.16e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 17569343  80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLD 121
Cdd:cd18200   5 LLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHD 46
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 696-732 5.62e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 35.23  E-value: 5.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17569343   696 QARRGGAVAVVRDTLYVIGG--HDGTQSLDTVEILDSPS 732
Cdd:pfam13854   2 VPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVYVLSLPT 40
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-241 8.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 37.63  E-value: 8.08e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17569343 187 FEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGI 241
Cdd:cd18244  82 FSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-124 8.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 37.25  E-value: 8.12e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 17569343  75 SIKNDLLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFN 124
Cdd:cd18261  10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFS 59
Kelch_6 pfam13964
Kelch motif;
555-599 9.76e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 9.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17569343   555 FDCTIHGGKVFAVAG-SNGNNDLKSCEIYDPKADVWAPLPNLATAR 599
Cdd:pfam13964   5 HSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 178-241 9.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 37.13  E-value: 9.99e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569343 178 EFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLAENLQLSNCIGI 241
Cdd:cd18341  70 VLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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