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Conserved domains on  [gi|1753147737|ref|XP_030896849|]
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protocadherin Fat 4 [Leptonychotes weddellii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2115-2210 1.79e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.79e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2115 YKVEINENTLTGTDIIQVYAADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTP 2194
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 1753147737 2195 RIDTTTVSIVLLDIND 2210
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1321-1416 1.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 1.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1321 FVDVLENMRIGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1400
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737 1401 SSTMSVVIHVRDFNDN 1416
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3318-3416 5.36e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.36e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3318 IYSVQISEGVPTGTHVTFVSAFDSDSvPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGT 3397
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1753147737 3398 PSATGSASLLVTLEDINDN 3416
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-349 1.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  254 HYQAGVPEDAAVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP 331
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  332 SLTGRAEALIQLLDVNDN 349
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2013-2106 3.30e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2013 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALS 2091
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1753147737 2092 SSTEVVVMVLDINDN 2106
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1311 3.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVS 1294
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1753147737 1295 LNSTCTLNIDILDENDN 1311
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3003-3100 4.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 4.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3003 HMSATIPESHSIGAIVRTVSARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWV 3082
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3083 ARTGYCSVTVNVIDVNDN 3100
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-685 5.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 5.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  588 YDVSVVENAPTGTELLVLRATDRDLGDNGTVRFSLQEaETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSP 667
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  668 PQSSMVRINVSLLDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2583-2679 3.17e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.17e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2583 PFVSEILENLSP-RKILTVSATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSP 2661
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2662 SQSTSVKVIINILDENDN 2679
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 693-789 3.39e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  693 QYFAHIQENEPGGSYITTVSATDPDLGLNGTIKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNL 771
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  772 QSPNQAIVTITVLDTQDN 789
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1000-1096 5.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 5.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1000 SYEVTLSESEPVNSRFFKVQAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVE 1078
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 1079 PLSATVNVTVILEDVNDN 1096
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-577 1.48e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.48e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  479 VYRVNLSEEAPRGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQG 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*....
gi 1753147737  559 VHPKFSYAQLVVTLLDVND 577
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1904-2003 3.29e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.29e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1904 SYSTSLMENLPLGSTVLVFNVTDADDGINSQLAYSIASGDSLGQFTVD-KNGVLKVLKSLDREIQSFYNLVVQVHDLPQL 1982
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|.
gi 1753147737 1983 PasrFTSTAHVSIILLDVNDN 2003
Cdd:cd11304     81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1801-1896 1.03e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1801 VYSFDIPEDTTPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGGG- 1879
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1753147737 1880 -QFTTIRVYFNVLDVNDN 1896
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3108-3203 3.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3108 EYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTLQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3186
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*..
gi 1753147737 3187 ERCSFATVNIQLKGTNE 3203
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2686-2778 5.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 5.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2686 IFSAYVPENSPLGYTVTRVTTSDEDIGINAISRYSIT--DTSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 2761
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1753147737 2762 -WTVSTDVTIFVTDINDN 2778
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3424-3520 9.21e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 9.21e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3424 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVP 3502
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3503 QMSSTGTVHITVIDQNDN 3520
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 899-992 1.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL-KQNPKNLFTINEKNGNISLLGPLDVHA-GSYQIEILASDMGVPQL 976
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737  977 SSSFILTVYVHDVNDN 992
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1428-1525 4.45e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPrGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPiet 1507
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 1753147737 1508 RRYALKNVTILVTDLNDN 1525
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2481-2575 4.67e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.67e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2481 EQTFMFPENQPVGTLVTTITGS---SLRGEPLSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFP 2557
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2558 PLSSYEKLDLTVLDVNDN 2575
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2219-2372 1.06e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2219 PYSVNVPENL--GTLprtILQVVARDDDQGSNSKLSYVLLGGNEDNAFTlsasgelrvtqsldretkehfvlmitatdsg 2296
Cdd:cd11304      1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFS------------------------------- 46

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1753147737 2297 ksclvvknlftiyriiggnsqftINPSTGQIITSALLDRETKENYTLVVVSSDAGSPePLSSSTSVLVTVTDVNDN 2372
Cdd:cd11304     47 -----------------------IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3213-3310 1.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3213 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNFGSir 3292
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 1753147737 3293 GADIDEVTVNVTVLDAND 3310
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-471 1.86e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  364 YASVDENAQVGTVVALLTVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDN 443
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  444 yGAPPgaavqaRSSVASLVIFVNDINDH 471
Cdd:cd11304     78 -GGPP------LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1105-1206 3.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1105 YTFYFEEEQRAGSFVGKVNAIDKDFGPNGEVRYSFEMVQPD--FELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVIAT 1182
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREE------QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1753147737 1183 DQGLPqPLKDQATVHVYMKDINDN 1206
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2786-2889 3.96e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 3.96e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2786 SYYLDCPELPEIGSKVTQVSATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQVLKYQnvsgfsnvNINRHSFIV 2863
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 1753147737 2864 TSSDRGNPSLLSETTVTINTVDSNDN 2889
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2898-2993 9.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 9.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2898 YFTPVTKNVKVGTKLIKVTAVDdRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNP 2977
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 1753147737 2978 PLSSQATVQIIVTEEN 2993
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 798-889 2.39e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 2.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  798 YSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS-GGT-- 872
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGpp 81

                           90
                   ....*....|....*..
gi 1753147737  873 VTGDTMVNITVKDLNDN 889
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-246 2.05e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 2.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  139 SIVVTFKEDSSSGRQVILDTATDSDIGSNGvdHRSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQL 218
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  219 LVEVEDKGEPKRRGYLQVNVTVQDINDN 246
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2380-2467 5.11e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2380 PYVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVYVKDGGSF 2456
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 1753147737 2457 PKTDSTTVTVR 2467
Cdd:cd11304     81 PLSSTATVTIT 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3772-3808 8.77e-18

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 79.22  E-value: 8.77e-18
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1753147737 3772 DIDECL-PSPCHNGGTCHNLVGGFSCSCPDGFTGRACE 3808
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1725-1793 8.89e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 8.89e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1753147737 1725 EGANALVTYTIISGADDS-FRIDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDH 1793
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3998-4118 4.07e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 4.07e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3998 SLEIKFRTRSENGILIHI--QESSNYTTVKIKNGKVHFTSDAGIAGKVERniPEVYVADGHWHTLLIGKNGTATVLSIDR 4075
Cdd:cd00110     23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1753147737 4076 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQA--HRDSQTGFDGCI 4118
Cdd:cd00110    101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCI 145
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1540-1622 7.94e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1540 SAVIGSVLTTIMAADPDEGANGEVEYEIINGDTD-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEL 1617
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATV 88


                   ....*
gi 1753147737 1618 TIILQ 1622
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-131 7.76e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 7.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   48 VFQVLEEQPPGTLVGTIQ-------TRPGFTYRLSESHA--LFAINSSTGALYTTATIDRESLPSdvINLVVL-----SS 113
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSatdpdsgENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 1753147737  114 SPTYPTEVRVLVRDLNDN 131
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3810-3844 8.01e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 62.27  E-value: 8.01e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 3810 DINECL-PGPCKNGAVCQNVPGSFNCVCKTGYTGNS 3844
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4181-4215 5.21e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 4181 DCAS-HPCQNGGSCEPgLHSGFTCNCPESHTGRTCE 4215
Cdd:cd00054      4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3919-3949 2.62e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 2.62e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1753147737 3919 CTHSPCQHGGMCMDYWSWQLCHCKEGLTGKY 3949
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1634-1725 4.23e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1634 YITILKEGEPIGTNVISIEAASP-RGSEAPVEYYIVSVRceektVGRLFTIGRQTGVIQTAAILDREQGAcLYLVDVYAI 1712
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPNGRIFYSILGGG-----PGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEAT 74

                           90
                   ....*....|...
gi 1753147737 1713 EKSTAfPRTQRAE 1725
Cdd:pfam00028   75 DSGGP-PLSSTAT 86
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2115-2210 1.79e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.79e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2115 YKVEINENTLTGTDIIQVYAADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTP 2194
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 1753147737 2195 RIDTTTVSIVLLDIND 2210
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1321-1416 1.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 1.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1321 FVDVLENMRIGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1400
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737 1401 SSTMSVVIHVRDFNDN 1416
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3318-3416 5.36e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.36e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3318 IYSVQISEGVPTGTHVTFVSAFDSDSvPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGT 3397
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1753147737 3398 PSATGSASLLVTLEDINDN 3416
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-349 1.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  254 HYQAGVPEDAAVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP 331
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  332 SLTGRAEALIQLLDVNDN 349
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2013-2106 3.30e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2013 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALS 2091
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1753147737 2092 SSTEVVVMVLDINDN 2106
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1311 3.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVS 1294
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1753147737 1295 LNSTCTLNIDILDENDN 1311
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3003-3100 4.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 4.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3003 HMSATIPESHSIGAIVRTVSARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWV 3082
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3083 ARTGYCSVTVNVIDVNDN 3100
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-685 5.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 5.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  588 YDVSVVENAPTGTELLVLRATDRDLGDNGTVRFSLQEaETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSP 667
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  668 PQSSMVRINVSLLDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2583-2679 3.17e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.17e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2583 PFVSEILENLSP-RKILTVSATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSP 2661
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2662 SQSTSVKVIINILDENDN 2679
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 693-789 3.39e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  693 QYFAHIQENEPGGSYITTVSATDPDLGLNGTIKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNL 771
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  772 QSPNQAIVTITVLDTQDN 789
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1000-1096 5.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 5.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1000 SYEVTLSESEPVNSRFFKVQAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVE 1078
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 1079 PLSATVNVTVILEDVNDN 1096
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-577 1.48e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.48e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  479 VYRVNLSEEAPRGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQG 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*....
gi 1753147737  559 VHPKFSYAQLVVTLLDVND 577
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1904-2003 3.29e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.29e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1904 SYSTSLMENLPLGSTVLVFNVTDADDGINSQLAYSIASGDSLGQFTVD-KNGVLKVLKSLDREIQSFYNLVVQVHDLPQL 1982
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|.
gi 1753147737 1983 PasrFTSTAHVSIILLDVNDN 2003
Cdd:cd11304     81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1801-1896 1.03e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1801 VYSFDIPEDTTPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGGG- 1879
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1753147737 1880 -QFTTIRVYFNVLDVNDN 1896
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1338-1418 1.91e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 108.21  E-value: 1.91e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1338 TATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNP 1417
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1418 P 1418
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3108-3203 3.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3108 EYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTLQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3186
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*..
gi 1753147737 3187 ERCSFATVNIQLKGTNE 3203
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2601-2681 4.01e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.44  E-value: 4.01e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2601 SATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSPSQSTSVKVIINILDENDNA 2680
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2681 P 2681
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2686-2778 5.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 5.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2686 IFSAYVPENSPLGYTVTRVTTSDEDIGINAISRYSIT--DTSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 2761
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1753147737 2762 -WTVSTDVTIFVTDINDN 2778
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3424-3520 9.21e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 9.21e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3424 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVP 3502
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3503 QMSSTGTVHITVIDQNDN 3520
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2134-2213 1.69e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.51  E-value: 1.69e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2134 AADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTPRIDTTTVSIVLLDINDFVP 2213
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3022-3102 9.63e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 9.63e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3022 SARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWVARTGYCSVTVNVIDVNDNS 3101
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  3102 P 3102
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3319-3411 1.80e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 103.15  E-value: 1.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3319 YSVQISEGVPTGTHVTFVSAFDSDSVPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGTP 3398
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 3399 SATGSASLLVTLE 3411
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1322-1410 5.20e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 5.20e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1322 VDVLENMRIGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRS 1401
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 1753147737 1402 STMSVVIHV 1410
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
2115-2206 9.51e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 9.51e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2115 YKVEINENTLTGTDIIQVYAADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTP 2194
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2195 RIDTTTVSIVLL 2206
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 899-992 1.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL-KQNPKNLFTINEKNGNISLLGPLDVHA-GSYQIEILASDMGVPQL 976
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737  977 SSSFILTVYVHDVNDN 992
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2015-2101 1.39e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 1.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2015 IPENTPIDTIVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALSSS 2093
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1753147737 2094 TEVVVMVL 2101
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
255-344 1.77e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.07  E-value: 1.77e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  255 YQAGVPEDAAVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS 332
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737  333 LTGRAEALIQLL 344
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
588-680 1.99e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.07  E-value: 1.99e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  588 YDVSVVENAPTGTELLVLRATDRDLGDNGTVRFSLQEAETDQrSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSP 667
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG-NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737  668 PQSSMVRINVSLL 680
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2029-2108 2.12e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 99.73  E-value: 2.12e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2029 QATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALSSSTEVVVMVLDINDNN 2107
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2108 P 2108
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1428-1525 4.45e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPrGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPiet 1507
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 1753147737 1508 RRYALKNVTILVTDLNDN 1525
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3005-3095 4.55e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.91  E-value: 4.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3005 SATIPESHSIGAIVRTVSARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWVAR 3084
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1753147737 3085 TGYCSVTVNVI 3095
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2481-2575 4.67e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.67e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2481 EQTFMFPENQPVGTLVTTITGS---SLRGEPLSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFP 2557
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2558 PLSSYEKLDLTVLDVNDN 2575
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1233-1313 5.29e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 5.29e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1233 SASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVSLNSTCTLNIDILDENDNT 1312
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1313 P 1313
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3337-3418 6.18e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 6.18e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3337 SAFDSDSVPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGTPSATGSASLLVTLEDINDN 3416
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1753147737  3417 GP 3418
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2584-2674 8.64e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.14  E-value: 8.64e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2584 FVSEILENLSP-RKILTVSATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSPS 2662
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2663 QSTSVKVIINIL 2674
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2219-2372 1.06e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2219 PYSVNVPENL--GTLprtILQVVARDDDQGSNSKLSYVLLGGNEDNAFTlsasgelrvtqsldretkehfvlmitatdsg 2296
Cdd:cd11304      1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFS------------------------------- 46

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1753147737 2297 ksclvvknlftiyriiggnsqftINPSTGQIITSALLDRETKENYTLVVVSSDAGSPePLSSSTSVLVTVTDVNDN 2372
Cdd:cd11304     47 -----------------------IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 274-351 1.14e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.14e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   274 AADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDP 351
Cdd:smart00112    2 ATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3213-3310 1.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3213 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNFGSir 3292
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 1753147737 3293 GADIDEVTVNVTVLDAND 3310
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-471 1.86e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  364 YASVDENAQVGTVVALLTVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDN 443
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  444 yGAPPgaavqaRSSVASLVIFVNDINDH 471
Cdd:cd11304     78 -GGPP------LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1105-1206 3.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1105 YTFYFEEEQRAGSFVGKVNAIDKDFGPNGEVRYSFEMVQPD--FELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVIAT 1182
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREE------QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1753147737 1183 DQGLPqPLKDQATVHVYMKDINDN 1206
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2786-2889 3.96e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 3.96e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2786 SYYLDCPELPEIGSKVTQVSATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQVLKYQnvsgfsnvNINRHSFIV 2863
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 1753147737 2864 TSSDRGNPSLLSETTVTINTVDSNDN 2889
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2898-2993 9.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 9.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2898 YFTPVTKNVKVGTKLIKVTAVDdRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNP 2977
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 1753147737 2978 PLSSQATVQIIVTEEN 2993
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-687 9.70e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 9.70e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   606 RATDRDLGDNGTVRFSLQEaETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSPPQSSMVRINVSLLDVNDN 685
Cdd:smart00112    1 SATDADSGENGKVTYSILS-GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1753147737   686 SP 687
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
694-784 1.04e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 1.04e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  694 YFAHIQENEPGGSYITTVSATDPDLGLNGTIKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQ 772
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737  773 SPNQAIVTITVL 784
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1019-1098 2.26e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 2.26e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1019 QAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVEPLSATVNVTVILEDVNDNR 1097
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1098 P 1098
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 712-791 2.31e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 2.31e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   712 SATDPDLGLNGTIKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNP 790
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737   791 P 791
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 798-889 2.39e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 2.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  798 YSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS-GGT-- 872
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGpp 81

                           90
                   ....*....|....*..
gi 1753147737  873 VTGDTMVNITVKDLNDN 889
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 498-580 3.86e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.86e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   498 SATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQGVHPKFSYAQLVVTLLDVND 577
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITT--TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1753147737   578 EKP 580
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
3424-3515 7.21e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 7.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3424 EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFtyYLLSTGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVP 3502
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 3503 QMSSTGTVHITVI 3515
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1001-1091 1.22e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1001 YEVTLSESEPVNSRFFKVQAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVEP 1079
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 1080 LSATVNVTVILE 1091
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
480-573 1.34e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.34e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  480 YRVNLSEEAPRGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQGV 559
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1753147737  560 HPKFSYAQLVVTLL 573
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-246 2.05e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 2.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  139 SIVVTFKEDSSSGRQVILDTATDSDIGSNGvdHRSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQL 218
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  219 LVEVEDKGEPKRRGYLQVNVTVQDINDN 246
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1215-1306 3.42e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.42e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVS 1294
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 1295 LNSTCTLNIDIL 1306
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1821-1898 4.58e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 4.58e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1821 ATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGGGQ--FTTIRVYFNVLDVNDNPP 1898
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1923-2005 5.29e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 5.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1923 NVTDADDGINSQLAYSIASGDSLGQFTVDKN-GVLKVLKSLDREIQSFYNLVVQVHDLPQLPASrftSTAHVSIILLDVN 2001
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 1753147737  2002 DNPP 2005
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1905-1998 1.56e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1905 YSTSLMENLPLGSTVLVFNVTDADDGINSQLAYSIASGDSLGQFTVDK-NGVLKVLKSLDREIQSFYNLVVQVHDLPQLP 1983
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 1753147737 1984 ASrftSTAHVSIILL 1998
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 916-994 1.75e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.75e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   916 KAVDPDEGVNGMVLYSLKQ-NPKNLFTINEKNGNISLLGPLDVHAGS-YQIEILASDMGVPQLSSSFILTVYVHDVNDNP 993
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPeYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737   994 P 994
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1802-1891 4.42e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 4.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1802 YSFDIPEDTTPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGG--G 1879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1753147737 1880 QFTTIRVYFNVL 1891
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2309-2374 4.51e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 4.51e-20
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737  2309 YRIIGGN--SQFTINPSTGQIITSALLDRETKENYTLVVVSSDAGSPePLSSSTSVLVTVTDVNDNPP 2374
Cdd:smart00112   15 YSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-248 3.10e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.10e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   158 TATDSDIGSNGvdHRSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVN 237
Cdd:smart00112    1 SATDADSGENG--KVTYSILSGNDDGLFSIDPE---TGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 1753147737   238 VTVQDINDNPP 248
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3112-3198 5.33e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 5.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3112 TVLENAPSGTTVIHLNATDADSGTNAVIAYTLQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCS 3190
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 1753147737 3191 FATVNIQL 3198
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
365-465 1.36e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  365 ASVDENAQVGTVVALLTVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDNy 444
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEATDS- 76

                           90       100
                   ....*....|....*....|.
gi 1753147737  445 GAPPgaavqaRSSVASLVIFV 465
Cdd:pfam00028   77 GGPP------LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2705-2780 2.09e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.09e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2705 TTSDEDIGINAISRYSITD--TSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNA 2779
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2780 P 2780
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2509-2577 3.20e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 3.20e-18
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1753147737  2509 LSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFPPLSSYEKLDLTVLDVNDNSP 2577
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2380-2467 5.11e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2380 PYVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVYVKDGGSF 2456
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 1753147737 2457 PKTDSTTVTVR 2467
Cdd:cd11304     81 PLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2805-2891 7.70e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.70e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2805 SATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQVLKYQNVSgfsnvninRHSFIVTSSDRGNPSLLSETTVTIN 2882
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQP--------EYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1753147737  2883 TVDSNDNAP 2891
Cdd:smart00112   73 VLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3772-3808 8.77e-18

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 79.22  E-value: 8.77e-18
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1753147737 3772 DIDECL-PSPCHNGGTCHNLVGGFSCSCPDGFTGRACE 3808
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1725-1793 8.89e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 8.89e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1753147737 1725 EGANALVTYTIISGADDS-FRIDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDH 1793
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1725-1795 1.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1753147737  1725 EGANALVTYTIISGADDS-FRIDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTP 1795
Cdd:smart00112    7 SGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3443-3521 1.76e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.76e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3443 TDPDLPPNqGPFTYYLLStGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVPQMSSTGTVHITVIDQNDNP 3521
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
1428-1520 3.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQmPRGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPiet 1507
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP--- 79

                           90
                   ....*....|...
gi 1753147737 1508 RRYALKNVTILVT 1520
Cdd:pfam00028   80 PLSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3998-4118 4.07e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 4.07e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3998 SLEIKFRTRSENGILIHI--QESSNYTTVKIKNGKVHFTSDAGIAGKVERniPEVYVADGHWHTLLIGKNGTATVLSIDR 4075
Cdd:cd00110     23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1753147737 4076 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQA--HRDSQTGFDGCI 4118
Cdd:cd00110    101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCI 145
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4003-4126 6.38e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 6.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 4003 FRTRSENGILIHI-QESSNYTTVKIKNGKVHFTSDAGiAGKVERNIPEVYVADGHWHTLLIGKNGTATVLSIDRIYNRDI 4081
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1753147737 4082 IHPTQDFGGLDVLTISLGGIPP--NQAHRDSQTGFDGCIASMLYGGE 4126
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPllLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1123-1208 7.90e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 7.90e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1123 NAIDKDFGPNGEVRYSF--EMVQPDFELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVIATDQGLPqPLKDQATVHVYM 1200
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGP-PLSSTATVTITV 73


                    ....*...
gi 1753147737  1201 KDINDNAP 1208
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1540-1622 7.94e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1540 SAVIGSVLTTIMAADPDEGANGEVEYEIINGDTD-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEL 1617
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATV 88


                   ....*
gi 1753147737 1618 TIILQ 1622
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3127-3206 8.96e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 8.96e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3127 NATDADSGTNAVIAYTL-QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYV 3205
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  3206 P 3206
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1443-1527 9.32e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 9.32e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1443 TAHDPDADINGQLSYTIIQQmPRGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPietRRYALKNVTILVTDL 1522
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITVLDV 76


                    ....*
gi 1753147737  1523 NDNVP 1527
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
2482-2570 1.08e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2482 QTFMFPENQPVGTLVTTITGSSLRGEP---LSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFPP 2558
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2559 LSSYEKLDLTVL 2570
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3772-3808 2.03e-16

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 75.36  E-value: 2.03e-16
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1753147737  3772 DIDECL-PSPCHNGGTCHNLVGGFSCSCPDGFT-GRACE 3808
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-473 2.70e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.70e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   381 TVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDNyGAPPgaavqaRSSVAS 460
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATDG-GGPP------LSSTAT 68

                            90
                    ....*....|...
gi 1753147737   461 LVIFVNDINDHPP 473
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
798-883 2.84e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.84e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  798 YSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS---GGT 872
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 1753147737  873 VTGDTMVNITV 883
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2687-2773 4.03e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 4.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2687 FSAYVPENSPLGYTVTRVTTSDEDIGINAISRYSIT--DTSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG--- 2761
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 1753147737 2762 WTVSTDVTIFVT 2773
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 823-891 4.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 4.30e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1753147737   823 NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS---GGTVTGDTMVNITVKDLNDNSP 891
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
3998-4126 5.28e-16

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 77.38  E-value: 5.28e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3998 SLEIKFRTRSENGILIHIQES--SNYTTVKIKNGKVHFTSDAGiAGKVERNIPEVYVADGHWHTLLIGKNGTATVLSIDR 4075
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1753147737  4076 IYNRDIIHPTQDFgGLDVLT-ISLGGIPPNQAHRDS--QTGFDGCIASMLYGGE 4126
Cdd:smart00282   80 GNRVSGESPGGLT-ILNLDGpLYLGGLPEDLKLPPLpvTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
899-987 9.59e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYS-LKQNPKNLFTINEKNGNISLLGPLDV-HAGSYQIEILASDMGVPQL 976
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDReSIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1753147737  977 SSSFILTVYVH 987
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2920-2997 1.86e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.86e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737  2920 DRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNPPLSSQATVQIIVTEENYHTP 2997
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3232-3312 3.27e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 3.27e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3232 ASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNFGSIRgaDIDEVTVNVTVLDANDP 3311
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 1753147737  3312 P 3312
Cdd:smart00112   80 A 80
Cadherin pfam00028
Cadherin domain;
2787-2882 4.55e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2787 YYLDCPELPEIGSKVTQVSATDPDEGSNGQVFYFIKSQSEY--FRINATTGEIFNKQVLKYQnvsgfsnvNINRHSFIVT 2864
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*...
gi 1753147737 2865 SSDRGNPSLLSETTVTIN 2882
Cdd:pfam00028   73 ATDSGGPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
3213-3306 4.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3213 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNfGSIR 3292
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 1753147737 3293 GADiDEVTVNVTVL 3306
Cdd:pfam00028   80 PLS-STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2898-2990 6.46e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2898 YFTPVTKNVKVGTKLIKVTAVDdRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNP 2977
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 2978 PLSSQATVQIIVT 2990
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-241 6.79e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  140 IVVTFKEDSSSGRQVILDTATDSDIGSNGVDhrSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQLL 219
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI--FYSILGGGPGGNFRIDPD---TGD-----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|..
gi 1753147737  220 VEVEDKGEPKRRGYLQVNVTVQ 241
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2220-2296 1.29e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.29e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737 2220 YSVNVPENLgTLPRTILQVVARDDDQGSNSKLSYVLLGGNEDNAFTL-SASGELRVTQSLDRETKEHFVLMITATDSG 2296
Cdd:pfam00028    1 YSASVPENA-PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSG 77
Cadherin pfam00028
Cadherin domain;
1105-1198 2.81e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1105 YTFYFEEEQRAGSFVGKVNAIDKDFGPNGEVRYSfeMVQPD----FELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVI 1180
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS--ILGGGpggnFRIDPDTGDISTTKPLDRES------IGEYELTVE 72

                           90
                   ....*....|....*...
gi 1753147737 1181 ATDQGLPqPLKDQATVHV 1198
Cdd:pfam00028   73 ATDSGGP-PLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1541-1622 1.39e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1541 AVIGSVLTTIMAADPDEGANGEVEYEIINGDTD-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELT 1618
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdRESIGEYELTVEATDSGGPPLSSTATVT 88


                   ....
gi 1753147737 1619 IILQ 1622
Cdd:pfam00028   89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-131 7.76e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 7.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   48 VFQVLEEQPPGTLVGTIQ-------TRPGFTYRLSESHA--LFAINSSTGALYTTATIDRESLPSdvINLVVL-----SS 113
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSatdpdsgENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 1753147737  114 SPTYPTEVRVLVRDLNDN 131
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2381-2466 2.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2381 YVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSGRNSE-KFHIDPLRGAIMAAGPLN--GASEVTFSVYVKDGGSFP 2457
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80


                   ....*....
gi 1753147737 2458 KTDSTTVTV 2466
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3810-3844 8.01e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 62.27  E-value: 8.01e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 3810 DINECL-PGPCKNGAVCQNVPGSFNCVCKTGYTGNS 3844
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3810-3841 1.01e-11

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 62.26  E-value: 1.01e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1753147737  3810 DINECL-PGPCKNGAVCQNVPGSFNCVCKTGYT 3841
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
Cadherin pfam00028
Cadherin domain;
1725-1787 1.68e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.68e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1753147737 1725 EGANALVTYTIISG-ADDSFRIDPESGDLIATKRLDRERRSKYSLLVRADDGL---QSSDMRINITV 1787
Cdd:pfam00028   25 LGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1552-1622 4.44e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 4.44e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1753147737  1552 AADPDEGANGEVEYEIINGDTDT-FIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQ 1622
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
EGF_CA pfam07645
Calcium-binding EGF domain;
3772-3801 9.83e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.48  E-value: 9.83e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 3772 DIDECL--PSPCHNGGTCHNLVGGFSCSCPDG 3801
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-133 2.11e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 2.11e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1753147737    70 FTYRLSESHA--LFAINSSTGALYTTATIDRESLPsdVINLVVL-----SSSPTYPTEVRVLVRDLNDNAP 133
Cdd:smart00112   13 VTYSILSGNDdgLFSIDPETGEITTTKPLDREEQP--EYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3814-3843 2.73e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 52.39  E-value: 2.73e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1753147737 3814 CLPGPCKNGAVCQNVPGSFNCVCKTGYTGN 3843
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4181-4215 5.21e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 4181 DCAS-HPCQNGGSCEPgLHSGFTCNCPESHTGRTCE 4215
Cdd:cd00054      4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
47-125 7.01e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 7.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   47 QVFQVLEEQPPGTLVGTIQTRP-------GFTYRLSESHA--LFAINSSTGALYTTATIDRESLPSDVINLVVLSSSP-- 115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpngRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|.
gi 1753147737  116 -TYPTEVRVLV 125
Cdd:pfam00028   81 lSSTATVTITV 91
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4182-4213 6.01e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.45  E-value: 6.01e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 4182 CASHPCQNGGSCEPGLHsGFTCNCPESHTGRT 4213
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4181-4215 7.92e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 7.92e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1753147737  4181 DCAS-HPCQNGGSCEPgLHSGFTCNCPESHT-GRTCE 4215
Cdd:smart00179    4 ECASgNPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3919-3949 2.62e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 2.62e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1753147737 3919 CTHSPCQHGGMCMDYWSWQLCHCKEGLTGKY 3949
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
1634-1725 4.23e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1634 YITILKEGEPIGTNVISIEAASP-RGSEAPVEYYIVSVRceektVGRLFTIGRQTGVIQTAAILDREQGAcLYLVDVYAI 1712
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPNGRIFYSILGGG-----PGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEAT 74

                           90
                   ....*....|...
gi 1753147737 1713 EKSTAfPRTQRAE 1725
Cdd:pfam00028   75 DSGGP-PLSSTAT 86
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3919-3951 2.32e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 2.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1753147737 3919 C-THSPCQHGGMCMDYWSWQLCHCKEGLTG-KYCE 3951
Cdd:cd00053      2 CaASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 2336-2511 3.68e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 43.88  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2336 ETKENYTLV--VVSSDAGSpeplSSSTSVLVTVTDVNdnpprfqHHPYVTHIPSPT--PPGSFVFAVTVTDAD------- 2404
Cdd:NF038112  1341 EVTADTQLTftLTVSDGTA----SATDTVTVTVRNVN-------RAPVANAGADQTvdERSTVTLSGSATDPDgdaltya 1409

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2405 ----IGPNSELhyslSGRNSEKfhidplrgAIMAAGPLNGASEVTFSVYVKDGGSFPKTDSTTVTVRFVNKAdfPKVRAK 2480
Cdd:NF038112  1410 wtqtAGPTVTL----TGADTAT--------ASFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNVNRA--PVAHAG 1475

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1753147737 2481 EQtfmfPENQPVGTLVTTITGSSLRGEPLSY 2511
Cdd:NF038112  1476 ES----ITVDEGSTVTLDASATDPDGDTLTY 1502
EGF_CA smart00179
Calcium-binding EGF-like domain;
3919-3951 5.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 5.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1753147737  3919 C-THSPCQHGGMCMDYWSWQLCHCKEGLT-GKYCE 3951
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2115-2210 1.79e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.97  E-value: 1.79e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2115 YKVEINENTLTGTDIIQVYAADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTP 2194
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 1753147737 2195 RIDTTTVSIVLLDIND 2210
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1321-1416 1.12e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 1.12e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1321 FVDVLENMRIGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1400
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737 1401 SSTMSVVIHVRDFNDN 1416
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3318-3416 5.36e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.36e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3318 IYSVQISEGVPTGTHVTFVSAFDSDSvPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGT 3397
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1753147737 3398 PSATGSASLLVTLEDINDN 3416
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-349 1.69e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  254 HYQAGVPEDAAVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVP 331
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  332 SLTGRAEALIQLLDVNDN 349
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2013-2106 3.30e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2013 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALS 2091
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1753147737 2092 SSTEVVVMVLDINDN 2106
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1215-1311 3.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 3.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVS 1294
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1753147737 1295 LNSTCTLNIDILDENDN 1311
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3003-3100 4.96e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.04  E-value: 4.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3003 HMSATIPESHSIGAIVRTVSARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWV 3082
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3083 ARTGYCSVTVNVIDVNDN 3100
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-685 5.84e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 5.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  588 YDVSVVENAPTGTELLVLRATDRDLGDNGTVRFSLQEaETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSP 667
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  668 PQSSMVRINVSLLDVNDN 685
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2583-2679 3.17e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.17e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2583 PFVSEILENLSP-RKILTVSATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSP 2661
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2662 SQSTSVKVIINILDENDN 2679
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 693-789 3.39e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 3.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  693 QYFAHIQENEPGGSYITTVSATDPDLGLNGTIKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNL 771
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737  772 QSPNQAIVTITVLDTQDN 789
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1000-1096 5.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 5.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1000 SYEVTLSESEPVNSRFFKVQAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVE 1078
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 1079 PLSATVNVTVILEDVNDN 1096
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-577 1.48e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.48e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  479 VYRVNLSEEAPRGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQG 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT--AKPLDREEQSSYTLTVTATDGG 78

                           90
                   ....*....|....*....
gi 1753147737  559 VHPKFSYAQLVVTLLDVND 577
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1904-2003 3.29e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.29e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1904 SYSTSLMENLPLGSTVLVFNVTDADDGINSQLAYSIASGDSLGQFTVD-KNGVLKVLKSLDREIQSFYNLVVQVHDLPQL 1982
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|.
gi 1753147737 1983 PasrFTSTAHVSIILLDVNDN 2003
Cdd:cd11304     81 P---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1801-1896 1.03e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 1.03e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1801 VYSFDIPEDTTPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGGG- 1879
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1753147737 1880 -QFTTIRVYFNVLDVNDN 1896
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1338-1418 1.91e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 108.21  E-value: 1.91e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1338 TATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNP 1417
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1418 P 1418
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3108-3203 3.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.04e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3108 EYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTLQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE 3186
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*..
gi 1753147737 3187 ERCSFATVNIQLKGTNE 3203
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2601-2681 4.01e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.44  E-value: 4.01e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2601 SATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSPSQSTSVKVIINILDENDNA 2680
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2681 P 2681
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2686-2778 5.50e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 5.50e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2686 IFSAYVPENSPLGYTVTRVTTSDEDIGINAISRYSIT--DTSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG-- 2761
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1753147737 2762 -WTVSTDVTIFVTDINDN 2778
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3424-3520 9.21e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 9.21e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3424 EGEVMENKRPGTLVMTLQSTDPDLPPNqGPFTYYLLStGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVP 3502
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 3503 QMSSTGTVHITVIDQNDN 3520
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2134-2213 1.69e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 105.51  E-value: 1.69e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2134 AADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTPRIDTTTVSIVLLDINDFVP 2213
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3022-3102 9.63e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 9.63e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3022 SARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWVARTGYCSVTVNVIDVNDNS 3101
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  3102 P 3102
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3319-3411 1.80e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 103.15  E-value: 1.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3319 YSVQISEGVPTGTHVTFVSAFDSDSVPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGTP 3398
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 3399 SATGSASLLVTLE 3411
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1322-1410 5.20e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 5.20e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1322 VDVLENMRIGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRS 1401
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 1753147737 1402 STMSVVIHV 1410
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
2115-2206 9.51e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 9.51e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2115 YKVEINENTLTGTDIIQVYAADGDEGTNGQVRYGIVDGNANQEFRIDSVTGAITVAKPLDREKTPTYSLTVQAADRGSTP 2194
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2195 RIDTTTVSIVLL 2206
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 899-992 1.07e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSL-KQNPKNLFTINEKNGNISLLGPLDVHA-GSYQIEILASDMGVPQL 976
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1753147737  977 SSSFILTVYVHDVNDN 992
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2015-2101 1.39e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 1.39e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2015 IPENTPIDTIVFKAQATDPDSGPNSYIEYTLLN-PLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALSSS 2093
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 1753147737 2094 TEVVVMVL 2101
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
255-344 1.77e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.07  E-value: 1.77e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  255 YQAGVPEDAAVGSSVLQVAAADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS 332
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737  333 LTGRAEALIQLL 344
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
588-680 1.99e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.07  E-value: 1.99e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  588 YDVSVVENAPTGTELLVLRATDRDLGDNGTVRFSLQEAETDQrSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSP 667
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG-NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737  668 PQSSMVRINVSLL 680
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2029-2108 2.12e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 99.73  E-value: 2.12e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2029 QATDPDSGPNSYIEYTLL-NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPALSSSTEVVVMVLDINDNN 2107
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2108 P 2108
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1428-1525 4.45e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPrGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPiet 1507
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 1753147737 1508 RRYALKNVTILVTDLNDN 1525
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3005-3095 4.55e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.91  E-value: 4.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3005 SATIPESHSIGAIVRTVSARDRDAAMNGLIGYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISATDGGWVAR 3084
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1753147737 3085 TGYCSVTVNVI 3095
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2481-2575 4.67e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 4.67e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2481 EQTFMFPENQPVGTLVTTITGS---SLRGEPLSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFP 2557
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1753147737 2558 PLSSYEKLDLTVLDVNDN 2575
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1233-1313 5.29e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 5.29e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1233 SASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVSLNSTCTLNIDILDENDNT 1312
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1313 P 1313
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3337-3418 6.18e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 6.18e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3337 SAFDSDSVPSWsRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGTPSATGSASLLVTLEDINDN 3416
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1753147737  3417 GP 3418
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2584-2674 8.64e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.14  E-value: 8.64e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2584 FVSEILENLSP-RKILTVSATDKDSGPNGQLDYEIVNGNKEHSFAINHATGEIRSIRPLDREKISQYVLTIKSSDKGSPS 2662
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2663 QSTSVKVIINIL 2674
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2219-2372 1.06e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2219 PYSVNVPENL--GTLprtILQVVARDDDQGSNSKLSYVLLGGNEDNAFTlsasgelrvtqsldretkehfvlmitatdsg 2296
Cdd:cd11304      1 SYEVSVPENAppGTV---VLTVSATDPDSGENGEVTYSIVSGNEDGLFS------------------------------- 46

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1753147737 2297 ksclvvknlftiyriiggnsqftINPSTGQIITSALLDRETKENYTLVVVSSDAGSPePLSSSTSVLVTVTDVNDN 2372
Cdd:cd11304     47 -----------------------IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 274-351 1.14e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.14e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   274 AADADEGTNADIRYRL--QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDP 351
Cdd:smart00112    2 ATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3213-3310 1.61e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3213 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNFGSir 3292
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 1753147737 3293 GADIDEVTVNVTVLDAND 3310
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 364-471 1.86e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 1.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  364 YASVDENAQVGTVVALLTVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDN 443
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  444 yGAPPgaavqaRSSVASLVIFVNDINDH 471
Cdd:cd11304     78 -GGPP------LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1105-1206 3.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1105 YTFYFEEEQRAGSFVGKVNAIDKDFGPNGEVRYSFEMVQPD--FELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVIAT 1182
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREE------QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1753147737 1183 DQGLPqPLKDQATVHVYMKDINDN 1206
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2786-2889 3.96e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.61  E-value: 3.96e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2786 SYYLDCPELPEIGSKVTQVSATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQVLKYQnvsgfsnvNINRHSFIV 2863
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDRE--------EQSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 1753147737 2864 TSSDRGNPSLLSETTVTINTVDSNDN 2889
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2898-2993 9.33e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 9.33e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2898 YFTPVTKNVKVGTKLIKVTAVDdRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNP 2977
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 1753147737 2978 PLSSQATVQIIVTEEN 2993
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-687 9.70e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 9.70e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   606 RATDRDLGDNGTVRFSLQEaETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGSPPQSSMVRINVSLLDVNDN 685
Cdd:smart00112    1 SATDADSGENGKVTYSILS-GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1753147737   686 SP 687
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
694-784 1.04e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.06  E-value: 1.04e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  694 YFAHIQENEPGGSYITTVSATDPDLGLNGTIKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQ 772
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737  773 SPNQAIVTITVL 784
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1019-1098 2.26e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 2.26e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1019 QAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVEPLSATVNVTVILEDVNDNR 1097
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  1098 P 1098
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 712-791 2.31e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 2.31e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   712 SATDPDLGLNGTIKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNP 790
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737   791 P 791
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 798-889 2.39e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 2.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  798 YSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS-GGT-- 872
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdGGGpp 81

                           90
                   ....*....|....*..
gi 1753147737  873 VTGDTMVNITVKDLNDN 889
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 498-580 3.86e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.86e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   498 SATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQGVHPKFSYAQLVVTLLDVND 577
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITT--TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1753147737   578 EKP 580
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
3424-3515 7.21e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 7.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3424 EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFtyYLLSTGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVP 3502
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 3503 QMSSTGTVHITVI 3515
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1001-1091 1.22e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1001 YEVTLSESEPVNSRFFKVQAFDKDSGANGEIAYSIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLLVVASDRAVEP 1079
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 1080 LSATVNVTVILE 1091
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
480-573 1.34e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.34e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  480 YRVNLSEEAPRGSYVSGVSATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTgvAGGLDRELASQIVLNISARDQGV 559
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1753147737  560 HPKFSYAQLVVTLL 573
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-246 2.05e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 2.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  139 SIVVTFKEDSSSGRQVILDTATDSDIGSNGvdHRSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQL 218
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 1753147737  219 LVEVEDKGEPKRRGYLQVNVTVQDINDN 246
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1215-1306 3.42e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 3.42e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1215 YQATISESAANLTQVLRVSASDVDEGNNGLIHYFVMKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGAVS 1294
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 1295 LNSTCTLNIDIL 1306
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1821-1898 4.58e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 4.58e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1821 ATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGGGQ--FTTIRVYFNVLDVNDNPP 1898
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1923-2005 5.29e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 5.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1923 NVTDADDGINSQLAYSIASGDSLGQFTVDKN-GVLKVLKSLDREIQSFYNLVVQVHDLPQLPASrftSTAHVSIILLDVN 2001
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 1753147737  2002 DNPP 2005
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1905-1998 1.56e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1905 YSTSLMENLPLGSTVLVFNVTDADDGINSQLAYSIASGDSLGQFTVDK-NGVLKVLKSLDREIQSFYNLVVQVHDLPQLP 1983
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 1753147737 1984 ASrftSTAHVSIILL 1998
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 916-994 1.75e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.75e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   916 KAVDPDEGVNGMVLYSLKQ-NPKNLFTINEKNGNISLLGPLDVHAGS-YQIEILASDMGVPQLSSSFILTVYVHDVNDNP 993
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPeYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737   994 P 994
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1802-1891 4.42e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 4.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1802 YSFDIPEDTTPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPVTGVFNLTRVLDYEAQQYYILTVRAEDGG--G 1879
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1753147737 1880 QFTTIRVYFNVL 1891
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2309-2374 4.51e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 4.51e-20
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737  2309 YRIIGGN--SQFTINPSTGQIITSALLDRETKENYTLVVVSSDAGSPePLSSSTSVLVTVTDVNDNPP 2374
Cdd:smart00112   15 YSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-248 3.10e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.10e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   158 TATDSDIGSNGvdHRSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVN 237
Cdd:smart00112    1 SATDADSGENG--KVTYSILSGNDDGLFSIDPE---TGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 1753147737   238 VTVQDINDNPP 248
Cdd:smart00112   71 ITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3112-3198 5.33e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 5.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3112 TVLENAPSGTTVIHLNATDADSGTNAVIAYTLQSSDSD-LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCS 3190
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 1753147737 3191 FATVNIQL 3198
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
365-465 1.36e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 1.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  365 ASVDENAQVGTVVALLTVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDNy 444
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEATDS- 76

                           90       100
                   ....*....|....*....|.
gi 1753147737  445 GAPPgaavqaRSSVASLVIFV 465
Cdd:pfam00028   77 GGPP------LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2705-2780 2.09e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.09e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2705 TTSDEDIGINAISRYSITD--TSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNA 2779
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  2780 P 2780
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2509-2577 3.20e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 3.20e-18
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1753147737  2509 LSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFPPLSSYEKLDLTVLDVNDNSP 2577
Cdd:smart00112   13 VTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2380-2467 5.11e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 5.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2380 PYVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSGRN-SEKFHIDPLRGAIMAAGPLN--GASEVTFSVYVKDGGSF 2456
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 1753147737 2457 PKTDSTTVTVR 2467
Cdd:cd11304     81 PLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2805-2891 7.70e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 7.70e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  2805 SATDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQVLKYQNVSgfsnvninRHSFIVTSSDRGNPSLLSETTVTIN 2882
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQP--------EYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 1753147737  2883 TVDSNDNAP 2891
Cdd:smart00112   73 VLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3772-3808 8.77e-18

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 79.22  E-value: 8.77e-18
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1753147737 3772 DIDECL-PSPCHNGGTCHNLVGGFSCSCPDGFTGRACE 3808
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1725-1793 8.89e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.21  E-value: 8.89e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1753147737 1725 EGANALVTYTIISGADDS-FRIDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDH 1793
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1725-1795 1.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.55e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1753147737  1725 EGANALVTYTIISGADDS-FRIDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTP 1795
Cdd:smart00112    7 SGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3443-3521 1.76e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 1.76e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3443 TDPDLPPNqGPFTYYLLStGPATNYFSLNTA-GVLSTTREIDREQIADFYLSVITRDSGVPQMSSTGTVHITVIDQNDNP 3521
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
1428-1520 3.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1428 SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQmPRGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPiet 1507
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP--- 79

                           90
                   ....*....|...
gi 1753147737 1508 RRYALKNVTILVT 1520
Cdd:pfam00028   80 PLSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3998-4118 4.07e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 4.07e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3998 SLEIKFRTRSENGILIHI--QESSNYTTVKIKNGKVHFTSDAGIAGKVERniPEVYVADGHWHTLLIGKNGTATVLSIDR 4075
Cdd:cd00110     23 SISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPLNDGQWHSVSVERNGRSVTLSVDG 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1753147737 4076 IYNRDIIHPTQDFGGLDVLTISLGGIPPNQA--HRDSQTGFDGCI 4118
Cdd:cd00110    101 ERVVESGSPGGSALLNLDGPLYLGGLPEDLKspGLPVSPGFVGCI 145
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4003-4126 6.38e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 6.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 4003 FRTRSENGILIHI-QESSNYTTVKIKNGKVHFTSDAGiAGKVERNIPEVYVADGHWHTLLIGKNGTATVLSIDRIYNRDI 4081
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1753147737 4082 IHPTQDFGGLDVLTISLGGIPP--NQAHRDSQTGFDGCIASMLYGGE 4126
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPllLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1123-1208 7.90e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 7.90e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1123 NAIDKDFGPNGEVRYSF--EMVQPDFELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVIATDQGLPqPLKDQATVHVYM 1200
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGP-PLSSTATVTITV 73


                    ....*...
gi 1753147737  1201 KDINDNAP 1208
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1540-1622 7.94e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 7.94e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1540 SAVIGSVLTTIMAADPDEGANGEVEYEIINGDTD-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEL 1617
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATV 88


                   ....*
gi 1753147737 1618 TIILQ 1622
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3127-3206 8.96e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 8.96e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3127 NATDADSGTNAVIAYTL-QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYV 3205
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1753147737  3206 P 3206
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1443-1527 9.32e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 9.32e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  1443 TAHDPDADINGQLSYTIIQQmPRGNHFGIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPietRRYALKNVTILVTDL 1522
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITVLDV 76


                    ....*
gi 1753147737  1523 NDNVP 1527
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
2482-2570 1.08e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2482 QTFMFPENQPVGTLVTTITGSSLRGEP---LSYYIASGNLGSTFQIDQITGQVSISQPLDFEKIQKYVIWIEARDGGFPP 2558
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1753147737 2559 LSSYEKLDLTVL 2570
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3772-3808 2.03e-16

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 75.36  E-value: 2.03e-16
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1753147737  3772 DIDECL-PSPCHNGGTCHNLVGGFSCSCPDGFT-GRACE 3808
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 381-473 2.70e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.70e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   381 TVTDADSPAaNGNISVQILGGNEQRHFEVQsskvPNLSLIKVASALDRERIPSYNLTVSVSDNyGAPPgaavqaRSSVAS 460
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATDG-GGPP------LSSTAT 68

                            90
                    ....*....|...
gi 1753147737   461 LVIFVNDINDHPP 473
Cdd:smart00112   69 VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
798-883 2.84e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 2.84e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  798 YSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS---GGT 872
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 1753147737  873 VTGDTMVNITV 883
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2687-2773 4.03e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 4.03e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2687 FSAYVPENSPLGYTVTRVTTSDEDIGINAISRYSIT--DTSLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG--- 2761
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 1753147737 2762 WTVSTDVTIFVT 2773
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 823-891 4.30e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 4.30e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1753147737   823 NSNISYLITTGDQKGMFAINQVTGHLTTASVIDREEQSFYQLKVVAS---GGTVTGDTMVNITVKDLNDNSP 891
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
3998-4126 5.28e-16

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 77.38  E-value: 5.28e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3998 SLEIKFRTRSENGILIHIQES--SNYTTVKIKNGKVHFTSDAGiAGKVERNIPEVYVADGHWHTLLIGKNGTATVLSIDR 4075
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1753147737  4076 IYNRDIIHPTQDFgGLDVLT-ISLGGIPPNQAHRDS--QTGFDGCIASMLYGGE 4126
Cdd:smart00282   80 GNRVSGESPGGLT-ILNLDGpLYLGGLPEDLKLPPLpvTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
899-987 9.59e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  899 SVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYS-LKQNPKNLFTINEKNGNISLLGPLDV-HAGSYQIEILASDMGVPQL 976
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDReSIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1753147737  977 SSSFILTVYVH 987
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2920-2997 1.86e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.86e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737  2920 DRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNPPLSSQATVQIIVTEENYHTP 2997
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3232-3312 3.27e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 3.27e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  3232 ASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNFGSIRgaDIDEVTVNVTVLDANDP 3311
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 1753147737  3312 P 3312
Cdd:smart00112   80 A 80
Cadherin pfam00028
Cadherin domain;
2787-2882 4.55e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2787 YYLDCPELPEIGSKVTQVSATDPDEGSNGQVFYFIKSQSEY--FRINATTGEIFNKQVLKYQnvsgfsnvNINRHSFIVT 2864
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*...
gi 1753147737 2865 SSDRGNPSLLSETTVTIN 2882
Cdd:pfam00028   73 ATDSGGPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
3213-3306 4.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3213 YYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGLLDREKEERVSLKVLAKNfGSIR 3292
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 1753147737 3293 GADiDEVTVNVTVL 3306
Cdd:pfam00028   80 PLS-STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2898-2990 6.46e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2898 YFTPVTKNVKVGTKLIKVTAVDdRDFGLNSEVEYLISNENHFGKFKLDNSTGWISVASSLISDLNQNFLIIVTARDKGNP 2977
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1753147737 2978 PLSSQATVQIIVT 2990
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
140-241 6.79e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  140 IVVTFKEDSSSGRQVILDTATDSDIGSNGVDhrSYRIIQGNEAGRFRLDITlnpSGEgaflhLVSKGGLDREVTPQYQLL 219
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI--FYSILGGGPGGNFRIDPD---TGD-----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|..
gi 1753147737  220 VEVEDKGEPKRRGYLQVNVTVQ 241
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2220-2296 1.29e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.29e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1753147737 2220 YSVNVPENLgTLPRTILQVVARDDDQGSNSKLSYVLLGGNEDNAFTL-SASGELRVTQSLDRETKEHFVLMITATDSG 2296
Cdd:pfam00028    1 YSASVPENA-PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSG 77
Cadherin pfam00028
Cadherin domain;
1105-1198 2.81e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.81e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1105 YTFYFEEEQRAGSFVGKVNAIDKDFGPNGEVRYSfeMVQPD----FELHAISGEIRNTRQFDRESlmrqrgTAVFSFTVI 1180
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS--ILGGGpggnFRIDPDTGDISTTKPLDRES------IGEYELTVE 72

                           90
                   ....*....|....*...
gi 1753147737 1181 ATDQGLPqPLKDQATVHV 1198
Cdd:pfam00028   73 ATDSGGP-PLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1541-1622 1.39e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1541 AVIGSVLTTIMAADPDEGANGEVEYEIINGDTD-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELT 1618
Cdd:pfam00028    9 APVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdRESIGEYELTVEATDSGGPPLSSTATVT 88


                   ....
gi 1753147737 1619 IILQ 1622
Cdd:pfam00028   89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 48-131 7.76e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 7.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   48 VFQVLEEQPPGTLVGTIQ-------TRPGFTYRLSESHA--LFAINSSTGALYTTATIDRESLPSdvINLVVL-----SS 113
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSatdpdsgENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 1753147737  114 SPTYPTEVRVLVRDLNDN 131
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2381-2466 2.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2381 YVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSGRNSE-KFHIDPLRGAIMAAGPLN--GASEVTFSVYVKDGGSFP 2457
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80


                   ....*....
gi 1753147737 2458 KTDSTTVTV 2466
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3810-3844 8.01e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 62.27  E-value: 8.01e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 3810 DINECL-PGPCKNGAVCQNVPGSFNCVCKTGYTGNS 3844
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3810-3841 1.01e-11

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 62.26  E-value: 1.01e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1753147737  3810 DINECL-PGPCKNGAVCQNVPGSFNCVCKTGYT 3841
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3775-3808 1.08e-11

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 62.11  E-value: 1.08e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 3775 EC-LPSPCHNGGTCHNLVGGFSCSCPDGFTGRA-CE 3808
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
Cadherin pfam00028
Cadherin domain;
1725-1787 1.68e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 1.68e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1753147737 1725 EGANALVTYTIISG-ADDSFRIDPESGDLIATKRLDRERRSKYSLLVRADDGL---QSSDMRINITV 1787
Cdd:pfam00028   25 LGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSSTATVTITV 91
Laminin_G_1 pfam00054
Laminin G domain;
4003-4118 4.08e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 4.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 4003 FRTRSENGILIHI--QESSNYTTVKIKNGKVHFTSDAGIAGKVERniPEVYVADGHWHTLLIGKNGTATVLSIDRIYNRD 4080
Cdd:pfam00054    1 FRTTEPSGLLLYNgtQTERDFLALELRDGRLEVSYDLGSGAAVVR--SGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1753147737 4081 IIHPTQDFGGLDVLT-ISLGGIPPNQAHR---DSQTGFDGCI 4118
Cdd:pfam00054   79 GESPLGATTDLDVDGpLYVGGLPSLGVKKrrlAISPSFDGCI 120
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1552-1622 4.44e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 4.44e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1753147737  1552 AADPDEGANGEVEYEIINGDTDT-FIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIILQ 1622
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
EGF_CA pfam07645
Calcium-binding EGF domain;
3772-3801 9.83e-10

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.48  E-value: 9.83e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 3772 DIDECL--PSPCHNGGTCHNLVGGFSCSCPDG 3801
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3776-3805 2.01e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 55.47  E-value: 2.01e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1753147737 3776 CLPSPCHNGGTCHNLVGGFSCSCPDGFTGR 3805
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3813-3843 1.03e-08

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 53.63  E-value: 1.03e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 3813 EC-LPGPCKNGAVCQNVPGSFNCVCKTGYTGN 3843
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF smart00181
Epidermal growth factor-like domain;
3775-3808 1.19e-08

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 53.29  E-value: 1.19e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1753147737  3775 ECLP-SPCHNGgTCHNLVGGFSCSCPDGFTG-RACE 3808
Cdd:smart00181    1 ECASgGPCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-133 2.11e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 2.11e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1753147737    70 FTYRLSESHA--LFAINSSTGALYTTATIDRESLPsdVINLVVL-----SSSPTYPTEVRVLVRDLNDNAP 133
Cdd:smart00112   13 VTYSILSGNDdgLFSIDPETGEITTTKPLDREEQP--EYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3814-3843 2.73e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 52.39  E-value: 2.73e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1753147737 3814 CLPGPCKNGAVCQNVPGSFNCVCKTGYTGN 3843
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4181-4215 5.21e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1753147737 4181 DCAS-HPCQNGGSCEPgLHSGFTCNCPESHTGRTCE 4215
Cdd:cd00054      4 ECASgNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 3816-3846 3.27e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.13  E-value: 3.27e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1753147737 3816 PGPCKNGAVCQNVPGSFNCVCKTGYTGNSIT 3846
Cdd:pfam12947    5 NGGCHPNATCTNTGGSFTCTCNDGYTGDGVT 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3781-3802 5.97e-07

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 48.48  E-value: 5.97e-07
                           10        20
                   ....*....|....*....|..
gi 1753147737 3781 CHNGGTCHNLVGGFSCSCPDGF 3802
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
Cadherin pfam00028
Cadherin domain;
47-125 7.01e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 7.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737   47 QVFQVLEEQPPGTLVGTIQTRP-------GFTYRLSESHA--LFAINSSTGALYTTATIDRESLPSDVINLVVLSSSP-- 115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpngRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|.
gi 1753147737  116 -TYPTEVRVLV 125
Cdd:pfam00028   81 lSSTATVTITV 91
EGF_CA pfam07645
Calcium-binding EGF domain;
3810-3839 1.80e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 3810 DINECLPGP--CKNGAVCQNVPGSFNCVCKTG 3839
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
3813-3843 3.19e-06

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 46.36  E-value: 3.19e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1753147737  3813 ECLP-GPCKNGaVCQNVPGSFNCVCKTGYTGN 3843
Cdd:smart00181    1 ECASgGPCSNG-TCINTPGSYTCSCPPGYTGD 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4182-4213 6.01e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.45  E-value: 6.01e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1753147737 4182 CASHPCQNGGSCEPGLHsGFTCNCPESHTGRT 4213
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4181-4215 7.92e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 7.92e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1753147737  4181 DCAS-HPCQNGGSCEPgLHSGFTCNCPESHT-GRTCE 4215
Cdd:smart00179    4 ECASgNPCQNGGTCVN-TVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4181-4215 1.97e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.39  E-value: 1.97e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1753147737 4181 DCA-SHPCQNGGSCEPgLHSGFTCNCPESHTG-RTCE 4215
Cdd:cd00053      1 ECAaSNPCSNGGTCVN-TPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3919-3949 2.62e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 2.62e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1753147737 3919 CTHSPCQHGGMCMDYWSWQLCHCKEGLTGKY 3949
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3327-3416 3.73e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.41  E-value: 3.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3327 VPTGTHV------TFVSAFDSDSVPSWSRFSYFIGSGNEN--GAFSINPQTGQITVTAELDRETLPIYNLTVLAVDSGTP 3398
Cdd:cd00031      1 IPDGSAVegrsrgSFRVSIPTDLIASSGEIIKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                           90
                   ....*....|....*...
gi 1753147737 3399 SATGSASLLVTLEDINDN 3416
Cdd:cd00031     81 VPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
1634-1725 4.23e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.98  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 1634 YITILKEGEPIGTNVISIEAASP-RGSEAPVEYYIVSVRceektVGRLFTIGRQTGVIQTAAILDREQGAcLYLVDVYAI 1712
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPNGRIFYSILGGG-----PGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEAT 74

                           90
                   ....*....|...
gi 1753147737 1713 EKSTAfPRTQRAE 1725
Cdd:pfam00028   75 DSGGP-PLSSTAT 86
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 3778-3804 4.99e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 4.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 1753147737 3778 PSPCHNGGTCHNLVGGFSCSCPDGFTG 3804
Cdd:pfam12947    5 NGGCHPNATCTNTGGSFTCTCNDGYTG 31
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-685 9.50e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 9.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737  589 DVSVVENApTGTELLVLRATDRDLGDNGTVRFSLQEAETDQRSFRLDPVSGRLSTIASLDREEQAFYSLLVLATDLGS-P 667
Cdd:cd00031      3 DGSAVEGR-SRGSFRVSIPTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAnV 81

                           90
                   ....*....|....*...
gi 1753147737  668 PQSSMVrINVSLLDVNDN 685
Cdd:cd00031     82 PQTSSV-FSIEVYDENDN 98
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3819-3840 2.76e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 40.78  E-value: 2.76e-04
                           10        20
                   ....*....|....*....|..
gi 1753147737 3819 CKNGAVCQNVPGSFNCVCKTGY 3840
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1743-1793 1.40e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.18  E-value: 1.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1753147737 1743 FRIDPESGDLIATKRLDRERRSKY---SLLVRADDGLQSSDMRINITVSDVNDH 1793
Cdd:cd00031     45 LHWEPHSGILEGLEKLDREDKGVHyisVSAASLGANVPQTSSVFSIEVYDENDN 98
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 3781-3807 1.53e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 1.53e-03
                           10        20
                   ....*....|....*....|....*..
gi 1753147737 3781 CHNGGTCHNLVGGfsCSCPDGFTGRAC 3807
Cdd:pfam07974    2 CSGRGTCVNQCGK--CVCDSGYQGATC 26
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 3778-3817 2.05e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 38.87  E-value: 2.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1753147737 3778 PSPCHNGGT----CHnLVGGFsCSCPDGFTGRACERdineCLPG 3817
Cdd:cd00055      1 PCDCNGHGSlsgqCD-PGTGQ-CECKPNTTGRRCDR----CAPG 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3919-3951 2.32e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 2.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1753147737 3919 C-THSPCQHGGMCMDYWSWQLCHCKEGLTG-KYCE 3951
Cdd:cd00053      2 CaASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 2336-2511 3.68e-03

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 43.88  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2336 ETKENYTLV--VVSSDAGSpeplSSSTSVLVTVTDVNdnpprfqHHPYVTHIPSPT--PPGSFVFAVTVTDAD------- 2404
Cdd:NF038112  1341 EVTADTQLTftLTVSDGTA----SATDTVTVTVRNVN-------RAPVANAGADQTvdERSTVTLSGSATDPDgdaltya 1409

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 2405 ----IGPNSELhyslSGRNSEKfhidplrgAIMAAGPLNGASEVTFSVYVKDGGSFPKTDSTTVTVRFVNKAdfPKVRAK 2480
Cdd:NF038112  1410 wtqtAGPTVTL----TGADTAT--------ASFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNVNRA--PVAHAG 1475

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1753147737 2481 EQtfmfPENQPVGTLVTTITGSSLRGEPLSY 2511
Cdd:NF038112  1476 ES----ITVDEGSTVTLDASATDPDGDTLTY 1502
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 3781-3817 5.63e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 37.72  E-value: 5.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1753147737 3781 CHNGGTCH---NLVGGfSCSCPDGFTGRACERdineCLPG 3817
Cdd:pfam00053    3 CNPHGSLSdtcDPETG-QCLCKPGVTGRHCDR----CKPG 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
3919-3951 5.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 5.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1753147737  3919 C-THSPCQHGGMCMDYWSWQLCHCKEGLT-GKYCE 3951
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 3298-3379 7.08e-03

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 38.86  E-value: 7.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1753147737 3298 EVTVNVTVLDANDPPIFSLNiySVQISEGVPTgthvtfVSAFDSDSVP-SWSRFSYFIGSGNENGAFSINPqTGQITVTA 3376
Cdd:pfam17963    1 TATVTVTVTPVNDAPVAVDD--SVTVTEDTVL------ANDSDPDGDPlTITSLTVTIVTAPANGTVTVNA-DGTLTYTP 71


                   ...
gi 1753147737 3377 ELD 3379
Cdd:pfam17963   72 NAG 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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