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Conserved domains on  [gi|1752348374|ref|XP_030835896|]
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cysteine-rich motor neuron 1 protein-like [Strongylocentrotus purpuratus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
505-558 7.87e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 40.49  E-value: 7.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1752348374 505 RGVMHHTGDRWHEDPCTECHCHDNRVECLDRshSCPRLPHPSCRLLEVKGQCCP 558
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKI--ICPPLDCPNPRLEIPPGECCP 55
WAP super family cl00156
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
205-248 1.85e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


The actual alignment was detected with superfamily member cd00199:

Pssm-ID: 469631 [Multi-domain]  Cd Length: 60  Bit Score: 36.66  E-value: 1.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1752348374 205 KPGQCLSV-TRMNCSTVFECTTDQGCGSNLKCCSNGCGMECVEPI 248
Cdd:cd00199    16 KPGRCPMVnPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
361-414 6.41e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 35.09  E-value: 6.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1752348374 361 CYQDRQRYHHGDEWSRDPCSLCRCWAGVIECLRMTCATPP-EGCEAVVIQGRCCP 414
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDcPNPRLEIPPGECCP 55
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
505-558 7.87e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 7.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1752348374 505 RGVMHHTGDRWHEDPCTECHCHDNRVECLDRshSCPRLPHPSCRLLEVKGQCCP 558
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKI--ICPPLDCPNPRLEIPPGECCP 55
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
205-248 1.85e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 36.66  E-value: 1.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1752348374 205 KPGQCLSV-TRMNCSTVFECTTDQGCGSNLKCCSNGCGMECVEPI 248
Cdd:cd00199    16 KPGRCPMVnPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
205-247 4.01e-03

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 4.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1752348374 205 KPGQCLSVTRMNCSTVfECTTDQGCGSNLKCCSNGCGMECVEP 247
Cdd:pfam00095   1 KPGCCPRLGARGCCRS-CCSSDDDCPGRQKCCSNGCGSVCVPP 42
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
361-414 6.41e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 6.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1752348374 361 CYQDRQRYHHGDEWSRDPCSLCRCWAGVIECLRMTCATPP-EGCEAVVIQGRCCP 414
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDcPNPRLEIPPGECCP 55
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
505-558 7.87e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 7.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1752348374 505 RGVMHHTGDRWHEDPCTECHCHDNRVECLDRshSCPRLPHPSCRLLEVKGQCCP 558
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKI--ICPPLDCPNPRLEIPPGECCP 55
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
205-248 1.85e-03

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 36.66  E-value: 1.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1752348374 205 KPGQCLSV-TRMNCSTVFECTTDQGCGSNLKCCSNGCGMECVEPI 248
Cdd:cd00199    16 KPGRCPMVnPPSLGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
205-247 4.01e-03

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 35.48  E-value: 4.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1752348374 205 KPGQCLSVTRMNCSTVfECTTDQGCGSNLKCCSNGCGMECVEP 247
Cdd:pfam00095   1 KPGCCPRLGARGCCRS-CCSSDDDCPGRQKCCSNGCGSVCVPP 42
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
361-414 6.41e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 6.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1752348374 361 CYQDRQRYHHGDEWSRDPCSLCRCWAGVIECLRMTCATPP-EGCEAVVIQGRCCP 414
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDcPNPRLEIPPGECCP 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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