|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
3-828 |
1.29e-143 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 446.79 E-value: 1.29e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 3 RGKLRIYLGAAPGVGKTYAMLSEGHRRVERGTDCVVAFVEHHGRPRTETVLRGLEQVPRRTLEHRGAALTEMDVDAVLAR 82
Cdd:PRK10490 22 RGKLKIFFGACAGVGKTYAMLQEAQRLRAQGLDVLVGVVETHGRKETAALLEGLTVLPPKRIHHRGRHISEFDLDAALAR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 83 RPAVALVDELAHTNAPGSRNPKRWQDVAELLAAGIDVVSTVNIQHLESLGDVVEAITGVRQRETVPDEVVRRADQIELVD 162
Cdd:PRK10490 102 RPALILMDELAHSNAPGSRHPKRWQDVEELLEAGIDVFTTVNVQHLESLNDVVGGVTGIQVRETVPDPFFDAADEVVLVD 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 163 MSPEALRRRMAHGNVYTSDKVDAALSNYFRPGNLTALRELALLWTADRVDEYLRKYRGEHNIRSTWQARERIVVGLTGGP 242
Cdd:PRK10490 182 LPPDDLRQRLNEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDDQMRAWRDHQGEEKVWHTRDAILLCIGHNT 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 243 EGRTLIRRATRLAEKgAGGEVLAVYIARSDGLTAASPKELAVQRTL--VEDLGGTFHHVIGDDVPTALLEFARGVNATQI 320
Cdd:PRK10490 262 GSEKLVRTAARLAAR-LGSVWHAVYVETPRLHRLPEKKRRAILSALrlAQELGAETATLSDPAEEKAVLRYAREHNLGKI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 321 VLG--SSRRRSWQYVFGPGVGQTvardsGPDLDVHIVTHGEVAKGRGLPVARGARLGRSRILAAWTIGVAGPACLAL--- 395
Cdd:PRK10490 341 IIGrrASRRWWRRESFADRLARL-----GPDLDLVIVALDEPPARAIAKAPDSRPFKEKWRVQIQGCLVAIALCALItli 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 396 ---LLTHVDAdlglANDMLLFLALTVAAALLGGFLPALASAAAGSLLLNWFFTPPVHRLTIADPKNIVALAVFLGVAMSV 472
Cdd:PRK10490 416 amqWLPAFDA----ANLVMLYLLGVVVVALFYGRWPSVVATVINVASFDLFFVAPRGTLAVSDVQYLLTFAVMLTVGLVI 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 473 AsvvDLAARRTHQA--ARLRAE-SEVLSYLAGSVLRGETSLD--ALLER-VRETFSMESVALLERED-EVEPWTPVASVG 545
Cdd:PRK10490 492 G---NLTAGVRYQArvARYREQrTRHLYEMSKALAVGLSPEDiaATSEHfLASTFQARSQLLLPDDNgKLQPLTHDQGMT 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 546 P--HPAARpEEADADMPVG-----------DRLALALSGRVL------PA--------EDRRVLGAFAAQAAVVLDRQRL 598
Cdd:PRK10490 569 PwdDAIAR-WSFDKGQPAGagtdtlpgvpyQILPLKSAQKTYgllavePGnlrqlmipEQQRLLETFTLLIANALERLTL 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 599 VGEAEEARKLAEGNKIRTSLLAAVSHDLRTPL------ASI-KASVSSLRSDDVEWSEQDRAELLEGIEagadrldhLVG 671
Cdd:PRK10490 648 TASEEQARLASEREQLRNALLAALSHDLRTPLtvlfgqAEIlTLDLASEGSPHARQASEIRQQVLNTTR--------LVN 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 672 NLLDMSRLRTGTVAPLMRVVDLDEVVPMALG----GVPDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVP 747
Cdd:PRK10490 720 NLLDMARIQSGGFNLRKEWLTLEEVVGSALQmlepGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAE 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 748 VTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLT 827
Cdd:PRK10490 800 IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVT 879
|
.
gi 1751489951 828 L 828
Cdd:PRK10490 880 L 880
|
|
| KdpD |
pfam02702 |
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase ... |
2-211 |
1.67e-134 |
|
Osmosensitive K+ channel His kinase sensor domain; This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport. The aligned region corresponds to the N-terminal cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure. It recognizes C-di-AMP and K+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460656 [Multi-domain] Cd Length: 210 Bit Score: 398.71 E-value: 1.67e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 2 GRGKLRIYLGAAPGVGKTYAMLSEGHRRVERGTDCVVAFVEHHGRPRTETVLRGLEQVPRRTLEHRGAALTEMDVDAVLA 81
Cdd:pfam02702 1 RRGRLKIFLGAAPGVGKTYAMLQEAHRLKKRGVDVVIGYVETHGRPETEALLEGLEVIPRREIEYRGRTLEEMDLDAILA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 82 RRPAVALVDELAHTNAPGSRNPKRWQDVAELLAAGIDVVSTVNIQHLESLGDVVEAITGVRQRETVPDEVVRRADQIELV 161
Cdd:pfam02702 81 RRPEVVLVDELAHTNAPGSRHPKRWQDVEELLDAGIDVYTTVNIQHLESLNDVVEQITGVRVRETVPDSVLDRADEVELV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1751489951 162 DMSPEALRRRMAHGNVYTSDKVDAALSNYFRPGNLTALRELALLWTADRV 211
Cdd:pfam02702 161 DLTPEELLERLKEGKVYPPEKAERALKNFFRKGNLTALRELALRRVADRV 210
|
|
| KdpD_non_kinase |
NF038185 |
KdpD-like non-kinase potassium sensor; Members of this family contain the N-terminal sensor ... |
1-355 |
8.74e-107 |
|
KdpD-like non-kinase potassium sensor; Members of this family contain the N-terminal sensor region, but lack the C-terminal histidine kinase region, of the sensor histidine kinase KdpD found broadly in species such as Escherichia coli, Mycobacterium tuberculosis, Clostridium acetobutylicum, and Staphylococcus aureus. Members are found in Bacillus anthracis and related species.
Pssm-ID: 468400 [Multi-domain] Cd Length: 373 Bit Score: 333.26 E-value: 8.74e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 1 MGRGKLRIYLGAAPGVGKTYAMLSEGHRRVERGTDCVVAFVEHHGRPRTETVLRGLEQVPRRTLEHRGAALTEMDVDAVL 80
Cdd:NF038185 16 QKRGKLKIYIGAAPGVGKTYKMLQDAHELKKEGIDVVIGLVETHGRKETEEQIGDLEIIPLKEIPYKGKEFQELDVEAII 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 81 ARRPAVALVDELAHTNAPGSRNPKRWQDVAELLAAGIDVVSTVNIQHLESLGDVVEAITGVRQRETVPDEVVRRADQIEL 160
Cdd:NF038185 96 KRNPQVVIIDELAHTNAPGSKNKKRYQDVQELLDAGISVMSAVNIQHLESVRDIVNQITGVKVRERIPDFILQKADEIQL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 161 VDMSPEALRRRMAHGNVYTSDKVDAALSNYFRPGNLTALRELALLWTADRVDEYLRKYRGEHNIRSTwQARERIVVGLTG 240
Cdd:NF038185 176 VDVTPETLRKRLREGKIYSPEKIEQSLNNFFTLGNLSALRELTLREVADDVDDRLEKYRNKGVVGPI-GINEKILVCVQY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 241 GPEGRTLIRRATRLAEKgAGGEVLAVYIARSD-GLTAASPKELAVQRTLVEDLGGTFHHVIGDD--VPTALLEFARGVNA 317
Cdd:NF038185 255 RPNAEKLIRRGWRMADR-LKADLYILHVYNEEeLLSEKNKKKIKEWQMLANQFNASFIVEEAKSrkPAQVIIEVAKQNNI 333
|
330 340 350
....*....|....*....|....*....|....*...
gi 1751489951 318 TQIVLGSSRRRSWQYVFGPGVGQTVARDSgPDLDVHIV 355
Cdd:NF038185 334 TQILLGQSARTRWEEIRKGSIVNAIMRQT-KNIDIHIV 370
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
602-828 |
5.74e-73 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 239.04 E-value: 5.74e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 602 AEEARKLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRsDDVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRT 681
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLL-DEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 682 GTVAPLMRVVDLDEVVPMALGGV------PDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASAL 755
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELrplaeeKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751489951 756 GDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
459-832 |
5.69e-59 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 206.33 E-value: 5.69e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 459 IVALAVFLGVAMSVASVVDLAARRTHQAARLRAESEVLSYLAGSVLRGETSLDALLERVRETFSMESVALLEREDEVEPW 538
Cdd:COG5002 19 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 539 TPVASVGPHPAARPEEADADMPVGDRLALALSGRVLPAEDRRVLGAFAAQAAVVLDRQRLVgEAEEARKlaegnkirtSL 618
Cdd:COG5002 99 LALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELE-RLEQMRR---------EF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 619 LAAVSHDLRTPLASIKASVSSLRSDDVEwSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVVP 698
Cdd:COG5002 169 VANVSHELRTPLTSIRGYLELLLDGAAD-DPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 699 MALGGVPDGSAE------LDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPD 772
Cdd:COG5002 248 EVVEELRPLAEEkgieleLDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPE 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751489951 773 EAKDGIFEPFQRfGDAPRG---SGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAAR 832
Cdd:COG5002 328 EDLPRIFERFYR-VDKSRSretGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
500-831 |
1.50e-58 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 202.83 E-value: 1.50e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 500 AGSVLRGETSLDALLERVRETFSMESVALLEREDEVEPWTPVASVGPHPAARPEEADADMPVGDRLALALSGRVLPAEDR 579
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 580 RVLGAFAAQAAVVLDRQRLVGEAEEArklaegNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDdvewSEQDRAELLEGI 659
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEA------NEAKSRFLANVSHELRTPLTAIRGYLELLLEE----LDEEQREYLETI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 660 EAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVVPMALGGVPDGSAE------LDIPETLPMVEVDKGLLERAVAN 733
Cdd:COG0642 151 LRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEkgieleLDLPDDLPTVRGDPDRLRQVLLN 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 734 IVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLG 813
Cdd:COG0642 231 LLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIE 310
|
330
....*....|....*...
gi 1751489951 814 AEDTPGGGLTMVLTLRAA 831
Cdd:COG0642 311 VESEPGKGTTFTVTLPLA 328
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
480-831 |
1.84e-41 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 155.73 E-value: 1.84e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 480 ARRTHQAARLRAESEVLSYLAGSVLRGETSLDALLERVRETFSMESVALLEREDEVEPWTPVASVGPHPAARPEEADADM 559
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 560 PVGDRLALALSGRVLPAEDRRVLGAFAAQAAVVLDRQRLVgEAEEARKLAEGNKIRTS-------LLAAVSHDLRTPLAS 632
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELE-RAEEELRELQEQLVQSEklaalgeLAAGIAHEINNPLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 633 IKASVSSLRSD-DVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTvaplMRVVDL----DEVVPMALGGVPDG 707
Cdd:COG4191 160 ILGNAELLRRRlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLneliDEALELLRPRLKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 708 SAEL--DIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVP--VTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFq 783
Cdd:COG4191 236 GIEVelDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1751489951 784 rFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAA 831
Cdd:COG4191 315 -FTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
459-831 |
1.69e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 150.71 E-value: 1.69e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 459 IVALAVFLGVAMSVASVVDLAARRTHQAARLRAESEVLSYLAGSVLRGETSLDALLERVRETFSMESVALLEREDEVEPW 538
Cdd:COG4251 115 LLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 539 TPVASVGPHPAARPEEADADMPVGDRLALALSGRVLPAEDRRVLGAFAAQAAVVLDRQRLVGEAEEARKLAEGNKIRTSL 618
Cdd:COG4251 195 LLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 619 LAA-----------VSHDLRTPLASIKASVSSLRSDDVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPl 687
Cdd:COG4251 275 LERsneeleqfayvASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF- 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 688 mRVVDLDEVVPMAL----GGVPDGSAELDIPEtLPMVEVDKGLLERAVANIVENAVKYSPGGVP--VTVAASALGDRVEL 761
Cdd:COG4251 354 -EPVDLNELLEEVLedlePRIEERGAEIEVGP-LPTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVF 431
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 762 RVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAA 831
Cdd:COG4251 432 SVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
533-835 |
2.25e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 148.57 E-value: 2.25e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 533 DEVEPWTPVASVGPHPAARPEEADADMPVGDRLALALSGRVLPAEDRRVlgafaaqaaVVLDRQRLVgEAEEARKLAEgn 612
Cdd:COG5000 136 EELLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVI---------VFDDITELL-RAERLAAWGE-- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 613 kirtsLLAAVSHDLRTPLASIKASVSSLR---SDDVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRtgtvAPLMR 689
Cdd:COG5000 204 -----LARRIAHEIKNPLTPIQLSAERLRrklADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 690 VVDLDEVVPMALG------GVPDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRV 763
Cdd:COG5000 275 PVDLNELLREVLAlyepalKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEV 354
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1751489951 764 VDRGPGVPDEAKDGIFEPFqrFgdAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAARGGP 835
Cdd:COG5000 355 SDNGPGIPEEVLERIFEPF--F--TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
727-828 |
2.30e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 120.79 E-value: 2.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAE 806
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1751489951 807 AMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
618-837 |
4.86e-32 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 128.43 E-value: 4.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 618 LLAAVSHDLRTPLASIKASVSSLRSDDvewSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRtgtvAPLMRVVD----L 693
Cdd:COG3852 138 LAAGLAHEIRNPLTGIRGAAQLLEREL---PDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNlhevL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 694 DEVVPMALGGVPDG-SAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGG----------VPVTVAASALGDRVELR 762
Cdd:COG3852 211 ERVLELLRAEAPKNiRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtrveRQVTLGGLRPRLYVRIE 290
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751489951 763 VVDRGPGVPDEAKDGIFEPFqrFgdAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAARGGPPA 837
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPF--F--TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
723-829 |
6.79e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.98 E-value: 6.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPR-GSGVGLGLAVA 801
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*...
gi 1751489951 802 RGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| USP_KdpD-like |
cd01987 |
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component ... |
233-355 |
1.01e-27 |
|
USP domain of the osmosensitive K+ channel histidine kinase family; The KdpDE two component system is widespread in bacteria and archaea; it controls potassium homeostasis and virulence by regulating the transcription of multiple genes, including a kdpFABC operon, which encodes a high-affinity P-type ATPase transporter. The KdpD histidine kinase (HK, EC:2.7.13.3) contain an N-terminal sensory cytoplasmic region (NTR) composed of KdpD' and universal stress protein (USP) domains, a canonical transmembrane domain, and a cytoplasmic C-terminal region with a transmitter GAF domain and an EnvZ-like catalytic HK domain. Proteins containing the USP domain are induced by many environmental stressors such as nutrient starvation, drought, extreme temperatures, high salinity, and the presence of uncouplers, antibiotics, and metals. It enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.
Pssm-ID: 467491 [Multi-domain] Cd Length: 124 Bit Score: 108.49 E-value: 1.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 233 RIVVGLTGGPEGRTLIRRATRLAEKGaGGEVLAVYIARSDG--LTAASPKELAVQRTLVEDLGGTFHHVIGDDVPTALLE 310
Cdd:cd01987 1 RILVCISSSPTSEKLIRRAARLAERL-NGELTAVYVETPEEsrLDEESQRRLLTNLKLAEELGAEVVSVEGDDVAEAIVE 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1751489951 311 FARGVNATQIVLGSSRRRSWQYVFGPGVGQTVARdSGPDLDVHIV 355
Cdd:cd01987 80 FARERNVTQIVLGQSRRRRWRRLFKGSLVDRLLR-EAPNIDVHIV 123
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
723-832 |
2.42e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 101.29 E-value: 2.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASAlGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRGSGVGLGLAVAR 802
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFST-ADKRGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 1751489951 803 GFAEAMGGTLGAEDTPGGGLTMVLTLRAAR 832
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
624-832 |
6.34e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.08 E-value: 6.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 624 HDLRTPLASIKASVSSLRSDdveWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVVPMALGG 703
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQED---PPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEA 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 704 VPDGSA------ELDIPETlpMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDG 777
Cdd:PRK11100 342 REAQAAakgitlRLRPDDA--RVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPR 419
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 778 IFEPF---QRFGDAPRGSgvGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAAR 832
Cdd:PRK11100 420 IFERFyslPRPANGRKST--GLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
618-828 |
2.08e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 105.82 E-value: 2.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 618 LLAAVSHDLRTPLASIKASVSSLR--SDDVEWSEQdRAELLEGIeagaDRLDHLVGNLLDMSRLRtgtvAPLMRVVDLDE 695
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRqqTSDPPSQEY-LSVVLREV----DRLNKVIDQLLEFSRPR----ESQWQPVSLNA 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 696 VVPMALG-----GVPDGSA-ELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGD-RVELRVVDRGP 768
Cdd:PRK11360 464 LVEEVLQlfqtaGVQARVDfETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNGC 543
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 769 GVPDEAKDGIFEPFqrFGDAPRGSGvgLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:PRK11360 544 GIDPELLKKIFDPF--FTTKAKGTG--LGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
615-822 |
2.69e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 100.76 E-value: 2.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 615 RTSLLAAVSHDLRTPLASIKASvSSLRSDDVEWseqdraeLLEGIEAGADRLDHLVGNLLDMsrLRTGTVAPlMRVVDLD 694
Cdd:PRK09467 229 RTLLMAGVSHDLRTPLTRIRLA-TEMMSEEDGY-------LAESINKDIEECNAIIEQFIDY--LRTGQEMP-MEMADLN 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 695 EV---VPMALGGVpDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASalGDRVELRVVDRGPGVP 771
Cdd:PRK09467 298 ALlgeVIAAESGY-EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTE--GKRAWFQVEDDGPGIP 374
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1751489951 772 DEAKDGIFEPFQRfGDAPRGS-GVGLGLAVARGFAEAMGGTLGAEDTPGGGL 822
Cdd:PRK09467 375 PEQLKHLFQPFTR-GDSARGSsGTGLGLAIVKRIVDQHNGKVELGNSEEGGL 425
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-828 |
4.04e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 91.62 E-value: 4.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGgvPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAP--RGSGVGLGLAVARGF 804
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdrESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....
gi 1751489951 805 AEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWL 102
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
620-828 |
5.97e-22 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 100.98 E-value: 5.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 620 AAVSHDLRTPLASIKASVSSLrsDDVEWSEQDRA-ELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVV- 697
Cdd:NF033092 377 ANVSHELRTPLTTMRSYLEAL--ADGAWKDPELApRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFn 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 698 --------PMALGGVpdgSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPG 769
Cdd:NF033092 455 yiidrfemILKNKNI---TFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLG 531
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751489951 770 VPDEAKDGIFEPFQRFgDAPR----GsGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:NF033092 532 IPKKDLDKIFDRFYRV-DKARsrkmG-GTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTL 592
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
615-821 |
1.22e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 98.52 E-value: 1.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 615 RTSLLAAVSHDLRTPLASIKASVSslRSDDVEWSEQdraellEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLD 694
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLE--MSDNLSAAES------QALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 695 EVVPMALGGV----PDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGgvPVTVAASALGDRVELRVVDRGPGV 770
Cdd:PRK10604 284 AWLSTHLADIqavtPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHS--RVRVSLLLDGNQACLIVEDDGPGI 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1751489951 771 PDEAKDGIFEPFQRFgDAPRG---SGVGLGLAVARGFAEAMGGTLGAEDTPGGG 821
Cdd:PRK10604 362 PPEERERVFEPFVRL-DPSRDratGGCGLGLAIVHSIALAMGGSVNCDESELGG 414
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
614-821 |
4.65e-21 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 95.35 E-value: 4.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 614 IRTSLLAAVSHDLRTPLASIKASVSSLRSD-DVEWSEQDRAelLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVD 692
Cdd:TIGR02966 113 MRRDFVANVSHELRTPLTVLRGYLETLADGpDEDPEEWNRA--LEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVD 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 693 LDEVV------PMALGGVPDGSAELDIpETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDR 766
Cdd:TIGR02966 191 MPALLdhlrdeAEALSQGKNHQITFEI-DGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDT 269
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 767 GPGVPDEAKDGIFEPFQRFgDAPRGS---GVGLGLAVARGFAEAMGGTLGAEDTPGGG 821
Cdd:TIGR02966 270 GIGIAPEHLPRLTERFYRV-DKSRSRdtgGTGLGLAIVKHVLSRHHARLEIESELGKG 326
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
606-835 |
8.35e-21 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 97.02 E-value: 8.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 606 RKLAEGNKIRTSLLAAVSHDLRTPLASIK--ASVSSLRSDDVEWSEQDRAELLEGieaGADRLDHLVGNLLDMSRLRTGT 683
Cdd:NF040691 262 RQLEELSRLQQRFVSDVSHELRTPLTTIRmaADVIHDSRDDFDPATARSAELLHT---ELDRFESLLSDLLEISRFDAGA 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 684 VAPLMRVVDLDEVVPMALGGVPDGSA------ELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGvPVTVAASALGD 757
Cdd:NF040691 339 AELDVEPVDLRPLVRRVVDALRQLAEragvelRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGEGK-PVVVTVAQDDT 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 758 RVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRG---SGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAARGG 834
Cdd:NF040691 418 AVAVTVRDHGVGLKPGEVALVFDRFWR-ADPARArttGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVAGD 496
|
.
gi 1751489951 835 P 835
Cdd:NF040691 497 R 497
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
617-828 |
1.86e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 95.38 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 617 SLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEqdraelLEGIEAGADRLDHLVGNLLDMSRLRTGTvaPLMRvvdldEV 696
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRRRQGESKE------LERIETEAQRLDSMINDLLVLSRNQQKN--HLER-----ET 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 697 VPMAL--GGVPDGS---AE--------LDIPETLPmVEVDKGLLERAVANIVENAVKYSPGgvPVTVAASALGDRVELRV 763
Cdd:PRK09470 312 FKANSlwSEVLEDAkfeAEqmgksltvSAPPGPWP-INGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITV 388
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751489951 764 VDRGPGVPDEAKDGIFEPFQRFGDA-PRGS-GVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:PRK09470 389 DDDGPGVPEEEREQIFRPFYRVDEArDRESgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
601-828 |
4.12e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 95.86 E-value: 4.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 601 EAEEARKLAE-GNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEQDraeLLEGIEAGADRLDHLVGNLLDMSRL 679
Cdd:PRK15347 383 ALAEAKQRAEqANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMD---LADTARQCTLSLLAIINNLLDFSRI 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 680 RTGTVAPLMRVVD----LDEVvpMALGGVPDGSAEL--------DIPETLpmvEVDKGLLERAVANIVENAVKYSP-GGV 746
Cdd:PRK15347 460 ESGQMTLSLEETAllplLDQA--MLTIQGPAQSKSLtlrtfvgaHVPLYL---HLDSLRLRQILVNLLGNAVKFTEtGGI 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 747 PVTVAASalGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGvgLGLAVARGFAEAMGGTLGAEDTPGGGLTMVL 826
Cdd:PRK15347 535 RLRVKRH--EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTG--LGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610
|
..
gi 1751489951 827 TL 828
Cdd:PRK15347 611 VL 612
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
624-822 |
7.01e-20 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 93.56 E-value: 7.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 624 HDLRTPLASIK--ASVSSLRSDDvewsEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVVPMAL 701
Cdd:PRK10337 246 HELRSPLAALKvqTEVAQLSDDD----PQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAV 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 702 GGV--PDGSAELDIPETLPMVEVDKG----LLERAVANIVENAVKYSPGGVPVTVAASALgdrvELRVVDRGPGVPDEAK 775
Cdd:PRK10337 322 MDIyhTAQQAGIDVRLTLNAHPVIRTgqplLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEAL 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1751489951 776 DGIFEPFQRfgdaPRG---SGVGLGLAVARGFAEAMGGTLGAEDTPGGGL 822
Cdd:PRK10337 398 ARIGERFYR----PPGqeaTGSGLGLSIVRRIAKLHGMNVSFGNAPEGGF 443
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
595-828 |
9.89e-20 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 92.93 E-value: 9.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 595 RQRLvgEAEEARK---LAEGNkirtsLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEqDRaELLEGIEAGADRLDHLVG 671
Cdd:PRK10364 221 RQLL--QDEMKRKeklVALGH-----LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGE-AH-QLAQVMAKEADRLNRVVS 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 672 NLLDMSRLRTGTVAPlmrvVDLDEVVPMALGGVPDGS------AELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGG 745
Cdd:PRK10364 292 ELLELVKPTHLALQA----VDLNDLINHSLQLVSQDAnsreiqLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQH 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 746 VPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFqrFgdAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMV 825
Cdd:PRK10364 368 GVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPY--F--TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFT 443
|
...
gi 1751489951 826 LTL 828
Cdd:PRK10364 444 LWL 446
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
604-828 |
1.32e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 88.85 E-value: 1.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 604 EARKLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRS----DDVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRL 679
Cdd:PRK09303 140 ENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELgqidEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRT 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 680 RTGTVAPLMRVVDLDEVVPMALGGVPD----GSAEL--DIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVaaS 753
Cdd:PRK09303 220 RWEALRFNPQKLDLGSLCQEVILELEKrwlaKSLEIqtDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITL--S 297
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 754 AL---GDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:PRK09303 298 MLhrtTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTL 375
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-828 |
2.26e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 78.27 E-value: 2.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGS--GVGLGLAV 800
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRAsgGSGLGLAI 80
|
90 100
....*....|....*....|....*...
gi 1751489951 801 ARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
596-840 |
2.80e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.88 E-value: 2.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 596 QRLVGEAEEARKLAE-GNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEQDRaelLEGIEAGADRLDHLVGNLL 674
Cdd:PRK11466 424 QELVIEHRQARAEAEkASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDD---LRAITDSGESLLTILNDIL 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 675 DMSRLRTGTVA------PLMRVVDLDEVVPMALGGVPDGSAEL--DIPETLPM-VEVDKGLLERAVANIVENAVKYSPGG 745
Cdd:PRK11466 501 DYSAIEAGGKNvsvsdePFEPRPLLESTLQLMSGRVKGRPIRLatDIADDLPTaLMGDPRRIRQVITNLLSNALRFTDEG 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 746 VpVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFgDAPRGsGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMV 825
Cdd:PRK11466 581 S-IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV-SGKRG-GTGLGLTISSRLAQAMGGELSATSTPEVGSCFC 657
|
250
....*....|....*
gi 1751489951 826 LTLRAARGGPPAHAA 840
Cdd:PRK11466 658 LRLPLRVATAPVPKT 672
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-822 |
2.81e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.22 E-value: 2.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASAlGDRVELRVVDRGPGVPDEAKDGIFEPFQRFgDAPRGSGVGLGLAVAR 802
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRS-DGQNYGGSGLGLSIVK 87
|
90 100
....*....|....*....|
gi 1751489951 803 GFAEAMGGTLGAEDTPGGGL 822
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGL 107
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
604-828 |
3.69e-17 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 86.71 E-value: 3.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 604 EARKLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDDVewSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGT 683
Cdd:PRK09959 701 ERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGL--SKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGN 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 684 VAPLMRVVDLDEVVP---MALGGVP-DGSAELDIPETLP---MVEVDKGLLERAVANIVENAVKYSP-GGVPVTVAASAL 755
Cdd:PRK09959 779 YQLQPQWVDIPTLVQntcHSFGAIAaSKSIALSCSSTFPdhyLVKIDPQAFKQVLSNLLSNALKFTTeGAVKITTSLGHI 858
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1751489951 756 GDR---VELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:PRK09959 859 DDNhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-822 |
5.42e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 77.10 E-value: 5.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYspGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRG-SGVGLGLAVARGFA 805
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYR-GDNARGtSGTGLGLAIVQRIS 77
|
90
....*....|....*..
gi 1751489951 806 EAMGGTLGAEDTPGGGL 822
Cdd:cd16950 78 DAHGGSLTLANRAGGGL 94
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
618-828 |
8.75e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 84.26 E-value: 8.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 618 LLAAVSHDLRTPLASIKASVSSLRSDDVEwseqDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPlmrvVDLDEVV 697
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDE----EQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----KDLNTLI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 698 --------PMA-LGGVpdgSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASAL-GDRVELRVVDRG 767
Cdd:COG5809 345 eevipllqPQAlLKNV---QIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEdDDKVVISVTDEG 421
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751489951 768 PGVPDEAKDGIFEPF----QRfgdaprgsGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:COG5809 422 CGIPEERLKKLGEPFyttkEK--------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
620-802 |
1.18e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 82.32 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 620 AAVSHDLRTPLASIKASVSSLRSDDVewseQDRAELLEGIeagaDRLDHLVGNLLDMSRLRTGTVAPLMRVVDL--DEVV 697
Cdd:PRK10755 142 ADVAHELRTPLAGIRLHLELLEKQHH----IDVAPLIARL----DQMMHTVEQLLQLARAGQSFSSGHYQTVKLleDVIL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 698 PM--------ALGGVPdgsaeLDIPETLPMVEV--DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRG 767
Cdd:PRK10755 214 PSqdelsemlEQRQQT-----LLLPESAADITVqgDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEG 288
|
170 180 190
....*....|....*....|....*....|....*..
gi 1751489951 768 PGVpDEAKDG-IFEPFQRFgDApRGSGVGLGLA-VAR 802
Cdd:PRK10755 289 PGI-DESKCGeLSKAFVRM-DS-RYGGIGLGLSiVSR 322
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
574-828 |
1.40e-16 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 83.21 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 574 LPAEDRRVLGAFAAqaavVLDRqrlvgeAEEA-RKLAEGNkirtsllAAVSHDLRTPLASIKASVSSLRSddvewSEQDR 652
Cdd:TIGR01386 216 APAELRELAQSFNA----MLGR------LEDAfQRLSQFS-------ADLAHELRTPLTNLLGQTQVALS-----QPRTG 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 653 AELLEGIEAGAD---RLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVV--------PMAlggvPDGSAELDIpETLPMVE 721
Cdd:TIGR01386 274 EEYREVLESNLEeleRLSRMVSDMLFLARADNGQLALERVRLDLAAELakvaeyfePLA----EERGVRIRV-EGEGLVR 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 722 VDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPR---GSGVGLGL 798
Cdd:TIGR01386 349 GDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYR-VDPARsnsGEGTGLGL 427
|
250 260 270
....*....|....*....|....*....|
gi 1751489951 799 AVARGFAEAMGGTLGAEdTPGGGLTMVLTL 828
Cdd:TIGR01386 428 AIVRSIMEAHGGRASAE-SPDGKTRFILRF 456
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
733-828 |
2.16e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 75.61 E-value: 2.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 733 NIVENAVKYSP-GGVPVTVAASAL---GDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGS--GVGLGLAVARGFAE 806
Cdd:cd16922 7 NLLGNAIKFTEeGEVTLRVSLEEEeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKygGTGLGLAISKKLVE 86
|
90 100
....*....|....*....|..
gi 1751489951 807 AMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16922 87 LMGGDISVESEPGQGSTFTFTL 108
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-828 |
5.38e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.39 E-value: 5.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGgvPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGS--GVGLGLAVARGF 804
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAtgGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....
gi 1751489951 805 AEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTW 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-822 |
6.57e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 74.03 E-value: 6.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEpfqRFGDAPRGS----GVGLGL 798
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFE---RFYSLPRPHsgqkSTGLGL 77
|
90 100
....*....|....*....|....
gi 1751489951 799 AVARGFAEAMGGTLGAEDTPGGGL 822
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDGVL 101
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
612-829 |
1.86e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 80.06 E-value: 1.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 612 NKIRTSLlAAVSHDLRTPLASIKASVSSLRSDDVEWSEQDRAELLEGIEagadRLDHLVGNLLDMSRLRTGTVApLMRvv 691
Cdd:PRK10815 264 TKYRTTL-TDLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAEPIMLEQIS----RISQQIGYYLHRASMRSEHNL-LSR-- 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 692 DLDEVVPM------ALG------GVpdgSAELDIPETLPMVEVDKGLLErAVANIVENAVKYSPGGVPVTVAASalGDRV 759
Cdd:PRK10815 336 ELHSVAPLldnltsALNkvyqrkGV---NITLDISPEITFVGEKNDFME-VMGNVLDNACKYCLEFVEISARQT--DEHL 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 760 ELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRgSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:PRK10815 410 HIVVEDDGPGIPESKRELIFDRGQR-ADTLR-PGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFG 477
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
727-821 |
5.42e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 71.75 E-value: 5.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAASAL-GDRVELRVVDRGPGVPDEAKDGIFEPFQRFGD--APRGSGVGLGLAVARG 803
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGssTRAHGGTGLGLSIVKE 84
|
90
....*....|....*...
gi 1751489951 804 FAEAMGGTLGAEDTPGGG 821
Cdd:cd16925 85 FVELHGGTVTVSDAPGGG 102
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
615-800 |
8.20e-15 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 77.74 E-value: 8.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 615 RTSLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEQDRAelLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDld 694
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKA--LHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVD-- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 695 evVPMALGGVPDGSAELDIPETLPMVEVDKGL--------LERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDR 766
Cdd:PRK11006 280 --VPMMLRVLEREAQTLSQGKHTITFEVDNSLkvfgnedqLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDN 357
|
170 180 190
....*....|....*....|....*....|....*..
gi 1751489951 767 GPGVPDEAKDGIFEPFQRFgDAPRGS---GVGLGLAV 800
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRV-DKARSRqtgGSGLGLAI 393
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
605-828 |
9.97e-15 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 77.75 E-value: 9.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 605 ARKLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRsDDVEwseQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTV 684
Cdd:PRK10549 230 ASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQ-DGVR---KFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGAL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 685 APLMRVVDLDEVVPMALGGVPDGSA------ELDIPETLPMVEvDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDR 758
Cdd:PRK10549 306 AYRKTPVDLVPLLEVAGGAFRERFAsrgltlQLSLPDSATVFG-DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKT 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1751489951 759 VELRVVDRGPGVPDEAKDGIFEPFQRF-GDAPRGS-GVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:PRK10549 385 LRLTFADSAPGVSDEQLQKLFERFYRTeGSRNRASgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
612-678 |
3.68e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.62 E-value: 3.68e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751489951 612 NKIRTSLLAAVSHDLRTPLASIKASVSSLRSDDVEWSEQDraELLEGIEAGADRLDHLVGNLLDMSR 678
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR--EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
615-682 |
5.93e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 67.24 E-value: 5.93e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 615 RTSLLAAVSHDLRTPLASIKASVSSLRSDDvewSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTG 682
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEK---LDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
710-828 |
5.99e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 69.58 E-value: 5.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 710 ELDIPETLPMVeVDKGLLERAVANIVENAVKYSPGGVPVTvaASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAP 789
Cdd:cd16954 22 SLDISPELRFP-GERNDLMELLGNLLDNACKWCLEFVEVT--ARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQR-LDEQ 97
|
90 100 110
....*....|....*....|....*....|....*....
gi 1751489951 790 RgSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16954 98 R-PGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-828 |
1.09e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 67.87 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKySPGGVP---VTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFqrFGDAPRGSGVGLGLAVARG 803
Cdd:cd16976 1 IQQVLMNLLQNALD-AMGKVEnprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF--FTTKPVGKGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 1751489951 804 FAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
601-832 |
1.58e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 74.59 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 601 EAEEArkLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRsdDVEWSEQDRAELlEGIEAGADRLDHLVGNLLDMSRLR 680
Cdd:PRK11091 271 RYQDA--LEKASRDKTTFISTISHELRTPLNGIVGLSRILL--DTELTAEQRKYL-KTIHVSAITLGNIFNDIIDMDKME 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 681 TGTVAPLMRVVD----LDEVVPMA-LGGVPDG-SAELDIPETLP-MVEVDKGLLERAVANIVENAVKYSP-GGVPVTVAA 752
Cdd:PRK11091 346 RRKLQLDNQPIDftdfLADLENLSgLQAEQKGlRFDLEPLLPLPhKVITDGTRLRQILWNLISNAVKFTQqGGVTVRVRY 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 753 SAlGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRG---SGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:PRK11091 426 EE-GDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGkpaTGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
...
gi 1751489951 830 AAR 832
Cdd:PRK11091 505 APA 507
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
615-682 |
2.47e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 65.28 E-value: 2.47e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 615 RTSLLAAVSHDLRTPLASIKASVSSLRSDDveWSEQDRaELLEGIEAGADRLDHLVGNLLDMSRLRTG 682
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTE--LSEEQR-EYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
709-818 |
3.12e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.15 E-value: 3.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 709 AELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDA 788
Cdd:cd16947 3 VEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDS 82
|
90 100 110
....*....|....*....|....*....|..
gi 1751489951 789 --PRGSGVGLGLAVARGFAEAMGGTLGAEDTP 818
Cdd:cd16947 83 rnSAKQGNGLGLTITKRLAESMGGSIYVNSKP 114
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-815 |
8.35e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 65.29 E-value: 8.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSP-GGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPF--QRFGDAPRGSGVGLGLAVARG 803
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFytERPANEAFGQHSGLGLSISRQ 80
|
90
....*....|..
gi 1751489951 804 FAEAMGGTLGAE 815
Cdd:cd16953 81 IIEAHGGISVAE 92
|
|
| DUF4118 |
pfam13493 |
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial ... |
441-488 |
1.29e-12 |
|
Domain of unknown function (DUF4118); This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pssm-ID: 463897 Cd Length: 107 Bit Score: 64.79 E-value: 1.29e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1751489951 441 NWFFTPPVHRLTIADPKNIVALAVFLGVAMSVASVVDLAARRTHQAAR 488
Cdd:pfam13493 59 NYFFTPPYFTFTVSDPGYLLTLVVFLLVALLTSTLTARLRRQARQARR 106
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-829 |
1.57e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 64.34 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVP----VTVAASALGDR-VELRVVDRGPGVPDEAKDGIFEPFQrfgdAPRGSGVGLGLAVA 801
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 1751489951 802 RGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
733-828 |
1.98e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 64.27 E-value: 1.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 733 NIVENAVKY-SPGGVP-VTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGSGVGLGLAVARGFAEAMGG 810
Cdd:cd16921 7 NLLGNAIKFrRPRRPPrIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIERHGG 86
|
90
....*....|....*...
gi 1751489951 811 TLGAEDTPGGGLTMVLTL 828
Cdd:cd16921 87 RIWLESEPGEGTTFYFTL 104
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-815 |
2.59e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 63.94 E-value: 2.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRGS-GVGLGLAVARGFA 805
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYR-GDNSRNTeGAGLGLSIAKAII 79
|
90
....*....|
gi 1751489951 806 EAMGGTLGAE 815
Cdd:cd16923 80 ELHGGSASAE 89
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
726-828 |
2.37e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 61.28 E-value: 2.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 726 LLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFqrFGDAPRGSGVGLGLAVARGFA 805
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPF--FTTKPVGEGTGLGLSLSYRII 80
|
90 100
....*....|....*....|...
gi 1751489951 806 EAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIIL 103
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
710-828 |
4.19e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 65.64 E-value: 4.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 710 ELDIPETLPMVEVDKGLLERAVANIVENA---VKYSPGGVP-VTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPfqrf 785
Cdd:COG3290 265 TIDIDSDLPDLPLSDTDLVTILGNLLDNAieaVEKLPEEERrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER---- 340
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1751489951 786 GD-APRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:COG3290 341 GFsTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
727-828 |
1.34e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 59.32 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAAS---------------ALGDRVELRVVDRGPGVPDEAKDGIFEPFqrFGDAPRG 791
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPF--FTTKEVG 78
|
90 100 110
....*....|....*....|....*....|....*..
gi 1751489951 792 SGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16919 79 KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
575-840 |
1.61e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 65.08 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 575 PAEDRRVLGAFAAQAAVVLDRQRLVGEAEE-ARKLAEGNKIRT--SLLAAVSHDLRTPLASI----KASVSSLRSDDVew 647
Cdd:PRK13837 407 PAGELQLLELALDCLAHAIERRRLETERDAlERRLEHARRLEAvgTLASGIAHNFNNILGAIlgyaEMALNKLARHSR-- 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 648 seqdRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEVVPMALGGVPDGSA-ELDIPETLPMVEVDKGL 726
Cdd:PRK13837 485 ----AARYIDEIISAGARARLIIDQILAFGRKGERNTKPFDLSELVTEIAPLLRVSLPPGVElDFDQDQEPAVVEGNPAE 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAASAL---------------GDRVELRVVDRGPGVPDEAKDGIFEPFqrFgdAPRG 791
Cdd:PRK13837 561 LQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlshgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPF--F--TTRA 636
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1751489951 792 SGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLRAARGGPPAHAA 840
Cdd:PRK13837 637 GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKVPVAPQA 685
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
594-812 |
4.84e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 63.17 E-value: 4.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 594 DRQRlvgeAEEARKLAEGNKIRTSLLAAV-------SHDLRTPLASIKASVSSLRSDDVEWSEQDRAELLEGIEAGADRL 666
Cdd:COG4192 409 ERKR----IEKNLRQTQDELIQAAKMAVVgqtmtslAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERM 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 667 DHLVGNLLDMSRLRTGTvaplMRVVDLDEVVPMALGGVPDGSAELDIPETLP---MVEVDKGLLERAVANIVENAVKYSP 743
Cdd:COG4192 485 DKIIKSLRQFSRKSDTP----LQPVDLRQVIEQAWELVESRAKPQQITLHIPddlMVQGDQVLLEQVLVNLLVNALDAVA 560
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1751489951 744 GGVPVTVAASALGDRVELRVVDRGPGVPDEAKdgIFEPFQRFGDAprgsGVGLGLAVARGFAEAMGGTL 812
Cdd:COG4192 561 TQPQISVDLLSNAENLRVAISDNGNGWPLVDK--LFTPFTTTKEV----GLGLGLSICRSIMQQFGGDL 623
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
601-828 |
1.91e-09 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 60.65 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 601 EAEEAR-KLAEGNKIRT-SLLAA-VSHDLRTPLASIKASVSSLRSDDVEWSEQDR------AELlegieagaDRLDHLVG 671
Cdd:COG5806 184 ENILLRkELQRAEKLEVvSELAAsIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQyirialEEL--------DRAEAIIT 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 672 NLLDMSRLRTGTvaplMRVVDLDEVV--------PMALG-GVpdgSAELDIPETLpMVEVDKGLLERAVANIVENAVKYS 742
Cdd:COG5806 256 DYLTFAKPQPEK----LEKIDVSEELehvidvlsPYANMnNV---EIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAM 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 743 PGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFqrFgdAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGL 822
Cdd:COG5806 328 PNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPY--F--STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGT 403
|
....*.
gi 1751489951 823 TMVLTL 828
Cdd:COG5806 404 TFTITL 409
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
585-826 |
2.12e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 60.84 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 585 FAAQAAVvlDRQRlvgEAEEARKLAEGNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDdVEWSEQDRAEL---LEGIEA 661
Cdd:PRK13557 138 FGSQLDV--SRRR---DAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAA-LSHPDADRGRMarsVENIRA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 662 GADRLDHLVGNLLDMSR---LRTgtvaplmRVVDL----DEVVPMA---LGGvpDGSAELDIPETLPMVEVDKGLLERAV 731
Cdd:PRK13557 212 AAERAATLTQQLLAFARkqrLEG-------RVLNLnglvSGMGELAertLGD--AVTIETDLAPDLWNCRIDPTQAEVAL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 732 ANIVENAVKYSPGGVPVTVAASAL---------------GDRVELRVVDRGPGVPDEAKDGIFEPFqrFGDAPRGSGVGL 796
Cdd:PRK13557 283 LNVLINARDAMPEGGRVTIRTRNVeiededlamyhglppGRYVSIAVTDTGSGMPPEILARVMDPF--FTTKEEGKGTGL 360
|
250 260 270
....*....|....*....|....*....|
gi 1751489951 797 GLAVARGFAEAMGGTLGAEDTPGGGLTMVL 826
Cdd:PRK13557 361 GLSMVYGFAKQSGGAVRIYSEVGEGTTVRL 390
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
618-828 |
2.62e-09 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 60.52 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 618 LLAAVSHDLRTPLASIKASVSSLRS--DDVEW------SEQDRAELLegieagadrldhlVGNLLDMSRlrtgTVAPLMR 689
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQLLQPgiEDKEEyfdimlSELDRIESI-------------ISEFLALAK----PQAVNKE 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 690 VVDLD----EVVPM-----ALGGVpdgSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVE 760
Cdd:COG5805 353 KENINeliqDVVTLleteaILHNI---QIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVI 429
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751489951 761 LRVVDRGPGVPDEAKDGIFEPFQRFGDaprgSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:COG5805 430 IRVIDEGIGIPEERLKKLGEPFFTTKE----KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-819 |
6.13e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.33 E-value: 6.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGG---------VPVTVAASALGDRVELR--VVDRGPGVPDEAKDGIFEPFQrfgdAPRGSGVG 795
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrtrTQRQVTLGHPRHRLALRvsVIDNGPGIPPDLQDTIFYPMV----SGRENGTG 76
|
90 100
....*....|....*....|....
gi 1751489951 796 LGLAVARGFAEAMGGTLGAEDTPG 819
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQPG 100
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-821 |
7.05e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 54.00 E-value: 7.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRGSG--VGLGLAV 800
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYR-DDTSRRSGghYGMGLYI 79
|
90 100
....*....|....*....|.
gi 1751489951 801 ARGFAEAMGGTLGAEDTPGGG 821
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGG 100
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-823 |
1.30e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 53.36 E-value: 1.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRF--GDAPRGSGVGLGLAVARGF 804
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVdiERCRNTGGTGLGLAIVKHV 80
|
90
....*....|....*....
gi 1751489951 805 AEAMGGTLGAEDTPGGGLT 823
Cdd:cd16952 81 MSRHDARLLIASELGKGSR 99
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
731-828 |
1.31e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.45 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 731 VANIVENAVKYS----PGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEpfQRFGDAPrGSGVGLGLAVARGFAE 806
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFE--RGVSTKG-QGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|..
gi 1751489951 807 AMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRI 103
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
465-829 |
1.39e-08 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 58.38 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 465 FLGVAMSVASVVDLAARRTHQaaRLRAESEVLSYLAGSVLRGET--------SLDALLERVRETFSMESVALLEREDEVE 536
Cdd:TIGR02938 108 FLGMHRDITELHRLEQVVANQ--KLLIESVVDAAPVAFVLLDPTgrvildnqEYKKLATDLRVKEPAHTVLDLLREAWRE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 537 PWTPVASVGPhpAARPEEADADmPVGDRLA--LALSGRVLPAEDRRVLGAFAAQAA-----VVLDRQRLVGEAEEARK-- 607
Cdd:TIGR02938 186 ALAENWPQQL--AFSNREARFD-RGGGRPArwLSCTGSVIGMESDCADSFFCAAEQpylllTIADISNLREEQERARLsa 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 608 ----LAEGNK---IRTSLLAAVsHDLRTPLASIKASVSSL-RSDDVEWSEQDRAELLEGIEAGADRLDHLVGNL--LDMS 677
Cdd:TIGR02938 263 lqalMAEEERleaIRETLSAAI-HRLQGPMNLISAAISVLqRRGDDAGNPASAAMLQQALSAGREHMEALRQVIpqSPQE 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 678 RLRTGTVAPLMR-VVDLDEVVPMALGGVPDGSAELDIPETLPMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALG 756
Cdd:TIGR02938 342 IVVPVNLNQILRdVITLSTPRLLAAGIVVDWQPAATLPAILGRELQLRSLFKALVDNAIEAMNIKGWKRRELSITTALNG 421
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751489951 757 DRVELRVVDRGPGVPDEAKDGIFEPFQRfGDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:TIGR02938 422 DLIVVSILDSGPGIPQDLRYKVFEPFFT-TKGGSRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
605-829 |
2.07e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 57.94 E-value: 2.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 605 ARKLA-EGNKIRTSLLAAVSHDLRTPL--------ASIKASVSSlrsddvewSEQDraeLLEGIEAGADRLDHLVGNLLD 675
Cdd:PRK11107 282 AKKRAqEAARIKSEFLANMSHELRTPLngvigftrQTLKTPLTP--------TQRD---YLQTIERSANNLLAIINDILD 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 676 MSRLRTGTVA------PLMRVvdLDEVVpMALGGvpdgSA-----EL------DIPETL---PMvevdkgLLERAVANIV 735
Cdd:PRK11107 351 FSKLEAGKLVlenipfSLRET--LDEVV-TLLAH----SAhekglELtlnidpDVPDNVigdPL------RLQQIITNLV 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 736 ENAVKYSPGG---VPVTVAASAlGDRVELR--VVDRGPGVPDEAKDGIFEPF--------QRFGdaprgsGVGLGLAVAR 802
Cdd:PRK11107 418 GNAIKFTESGnidILVELRALS-NTKVQLEvqIRDTGIGISERQQSQLFQAFrqadasisRRHG------GTGLGLVITQ 490
|
250 260
....*....|....*....|....*..
gi 1751489951 803 GFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:PRK11107 491 KLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
710-828 |
2.58e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 2.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 710 ELDIPETLPMVEVDKGLLEravaNIVENAVKY----SPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEpfqRF 785
Cdd:COG2972 324 EIEIDEELLDLLIPKLILQ----PLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE---EL 396
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1751489951 786 GDAPRGSGVGLGLAVAR---GFAEAMGGTLgaEDTPGGGLTMVLTL 828
Cdd:COG2972 397 SSKGEGRGIGLRNVRERlklYYGEEYGLEI--ESEPGEGTTVTIRI 440
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-828 |
1.01e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 51.00 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENA------VKYSPGGVPVTVAASALGdRVELRVVDRGPGVPDEAKDGIFEPFQrfgdAPRGSGVGL 796
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDG-RIVLIVCDNGKGFPREMRHRATEPYV----TTRPKGTGL 75
|
90 100 110
....*....|....*....|....*....|..
gi 1751489951 797 GLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
663-819 |
1.73e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 54.32 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 663 ADRLDHLVGNLLDMSRLRTGTVAPLMRVVD-LDEVVPMALGgvPDGSAELDIPETLPMVEVDKGLLERAVANIVENAVK- 740
Cdd:PRK11073 175 ADRLRNLVDRLLGPQRPGTHVTESIHKVAErVVQLVSLELP--DNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQa 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 741 YSPGGVPVTV------AASALGDRVEL----RVVDRGPGVPDEAKDGIFEPFQrfgdAPRGSGVGLGLAVARGFAEAMGG 810
Cdd:PRK11073 253 LGPEGGTITLrtrtafQLTLHGERYRLaariDIEDNGPGIPPHLQDTLFYPMV----SGREGGTGLGLSIARNLIDQHSG 328
|
....*....
gi 1751489951 811 TLGAEDTPG 819
Cdd:PRK11073 329 KIEFTSWPG 337
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
723-828 |
2.26e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.98 E-value: 2.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 723 DKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFqrF-GDAPRGSG--VGLGLA 799
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKG--FtGENGRNFQesTGMGLY 79
|
90 100
....*....|....*....|....*....
gi 1751489951 800 VARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:cd16948 80 LVKKLCDKLGHKIDVESEVGEGTTFTITF 108
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
737-828 |
2.30e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 49.09 E-value: 2.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 737 NAVKYSPGGVpVTVAASALGDRVELRVVDRGPGvpdeakdgifepfqrFGDAPRGSGVGLGLAVARGFAEAMGGTLGAED 816
Cdd:cd16917 11 NALKHAGASR-VRVTLSYTADELTLTVVDDGVG---------------FDGPAPPGGGGFGLLGMRERAELLGGTLTIGS 74
|
90
....*....|..
gi 1751489951 817 TPGGGLTMVLTL 828
Cdd:cd16917 75 RPGGGTRVTARL 86
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
718-818 |
3.11e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 54.01 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 718 PMVEVDKGLLERAVANIVENAVKYSPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFgDAPR---GSGV 794
Cdd:PRK09835 367 CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRV-DPSRqrkGEGS 445
|
90 100
....*....|....*....|....
gi 1751489951 795 GLGLAVARGFAEAMGGTLGAEDTP 818
Cdd:PRK09835 446 GIGLAIVKSIVVAHKGTVAVTSDA 469
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
630-828 |
1.88e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 46.92 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 630 LASIKASVSSLR---SDDVEWSEQDRAELLEGIEAGADRLDHLVGNLLDMSRLRTGTVAPLMRVVDLDEvvpmALGGVPd 706
Cdd:COG4585 69 LSAIKLQLEAARrllDADPEAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLL----RAAGIR- 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 707 gsAELDIPETLPMVEVDKGL-LERAVANIVENAVKYSPGGvPVTVAASALGDRVELRVVDRGPGvpdeakdgifepfqrf 785
Cdd:COG4585 144 --VELDVDGDPDRLPPEVELaLYRIVQEALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVG---------------- 204
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1751489951 786 GDAPRGSGVGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTL 828
Cdd:COG4585 205 FDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
730-809 |
2.68e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.52 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 730 AVANIVENAVKYSPGGvPVTVAASALGDRVELRVVDRGPGVPDEAKDgifepfQRFGDAPRGsgvGLGLAVARGFAEAMG 809
Cdd:COG2172 42 AVTNAVRHAYGGDPDG-PVEVELELDPDGLEIEVRDEGPGFDPEDLP------DPYSTLAEG---GRGLFLIRRLMDEVE 111
|
|
| UspA |
COG0589 |
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms]; |
232-355 |
4.51e-05 |
|
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
Pssm-ID: 440354 Cd Length: 136 Bit Score: 44.14 E-value: 4.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 232 ERIVVGLTGGPEGRTLIRRATRLAEKgAGGEVLAVYIARSDGLTAASPKE------------LAVQRTLVEDLGGTFH-H 298
Cdd:COG0589 3 KRILVPTDGSEEAERALEYAAELAKA-LGAELHLLHVVDPPPSAAAGPEEleeelreeaeeaLEEAAERLEEAGVEVEtV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1751489951 299 VIGDDVPTALLEFARGVNATQIVLGSSRRRSWQYVFGPGVGQTVARDSgpDLDVHIV 355
Cdd:COG0589 82 VREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHA--PCPVLVV 136
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
596-821 |
6.71e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 46.51 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 596 QRLVGEAEEArklaegNKIRTSLLAAVSHDLRTPLASIKASVSSLRSDDVEwSEQDRaeLLEGIEAGADRLDHLVGNLLD 675
Cdd:PRK10841 434 QEMAQAAEQA------SQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELP-KGVDR--LVTAMNNSSSLLLKIISDILD 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 676 MSRLR--------------------TGTVAPLmrvvdldeVVPMALGgvpdgsaeL------DIPETL---PMvevdkgL 726
Cdd:PRK10841 505 FSKIEseqlkieprefsprevinhiTANYLPL--------VVKKRLG--------LycfiepDVPVALngdPM------R 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGVpVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPFQRFGDAPRGS--GVGLGLAVARGF 804
Cdd:PRK10841 563 LQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNfqGTGLGLAICEKL 641
|
250
....*....|....*..
gi 1751489951 805 AEAMGGTLGAEDTPGGG 821
Cdd:PRK10841 642 INMMDGDISVDSEPGMG 658
|
|
| Usp |
pfam00582 |
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ... |
234-355 |
3.44e-04 |
|
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.
Pssm-ID: 425765 [Multi-domain] Cd Length: 137 Bit Score: 41.62 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 234 IVVGLTGGPEGRTLIRRATRLAEKgAGGEVLAVYIARSDGLTAASPKELAVQRTLVEDLG-----------------GTF 296
Cdd:pfam00582 1 ILVAVDGSEESKRALEWAAELAKA-RGAELILLHVIDPPPSGAASLADESAEEEELELELaeaealaaaaaaeaggvKVE 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1751489951 297 HHVIGDDVPTALLEFARGVNATQIVLGSSRRRSWQYVFGPGVGQTVARDSgpDLDVHIV 355
Cdd:pfam00582 80 VVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHA--PCPVLVV 136
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
730-826 |
5.66e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.56 E-value: 5.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 730 AVANIVENAVKYSPGGvPVTVAASALGDRVELRVVDRGPGvpdeakdgiFEPFQRFGDAPRGSGVGLGLAVARGFAEAmg 809
Cdd:cd16936 8 AVTNAVRHAYRHDGPG-PVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGGRGLALIRALMDE-- 75
|
90
....*....|....*...
gi 1751489951 810 gtLGAEDTPGGG-LTMVL 826
Cdd:cd16936 76 --VGYRRTPGGKtVWLEL 91
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
706-821 |
7.68e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.90 E-value: 7.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 706 DGSAELDIPETLPMVEvdkglLERAVANIVENAVKYS----PGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEP 781
Cdd:PRK15053 417 PGSQLSQLPPGLDSTE-----FAAIVGNLLDNAFEASlrsdEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQ 491
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1751489951 782 -FQRFGDAPRGSGVGLGLaVARgFAEAMGGTLGAEDTPGGG 821
Cdd:PRK15053 492 gVSTRADEPGEHGIGLYL-IAS-YVTRCGGVITLEDNDPCG 530
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
393-832 |
1.58e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.81 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 393 LALLLTHVDADLGLANDMLLFLALTVAAALLGGFLPALASAAAGSLLLNWFFTPPVHRLTIADPKNIVALAVFLGVAMSV 472
Cdd:COG3920 34 LALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 473 ASVVDLAARRTHQAARLRAESEVLSYLAGSVLRGETSLDALLERVRETFSMESVALLEREDEVEPWTPVASVGPHPAARP 552
Cdd:COG3920 114 AALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 553 EEADADMPVGDRLALALSGRVLPAEDRRVLGAFAAQAAVVLDRQRLVGEAEEARKLAEGNKIRTSLLAAVSHDLRTPLAS 632
Cdd:COG3920 194 LAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 633 IKASVSSLRSDdvewsEQDRAELLEGIEAGADRLDHLVGN-------LLDMSRLRTGTVAPL------------------ 687
Cdd:COG3920 274 IRLVITERKRA-----EEELEASLEEKELLLRELHHRVKNnlqvvssLLRLQARRADDPEARealeesqnriqalalvhe 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 688 -------MRVVDLDEVVPMALGGVPDGSAELDIPETLpmvEVDKGLLERAVAN--------IVENAVKYSPGGVP---VT 749
Cdd:COG3920 349 llyqsedWEGVDLRDYLRELLEPLRDSYGGRGIRIEL---DGPDVELPADAAVplglilneLVTNALKHAFLSGEggrIR 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 750 VAASALGDRVELRVVDRGPGVPDEAkdgifepfqrfgDAPRGSgvGLGLAVARGFAEAMGGTLGAEDTPGGGLTMVLTLR 829
Cdd:COG3920 426 VSWRREDGRLRLTVSDNGVGLPEDV------------DPPARK--GLGLRLIRALVRQLGGTLELDRPEGTRVRITFPLA 491
|
...
gi 1751489951 830 AAR 832
Cdd:COG3920 492 ELA 494
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
720-796 |
1.69e-03 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 41.39 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 720 VEVDKGLLERAVA-----NIVENAVKY----SPGGVPVTVAASALGDRVELRVVDRGPGVPDEAKDgifepfqrfgdapR 790
Cdd:COG3275 242 IDIDEELLDLLIPplllqPLVENAIKHgissKEGGGTISISIEVEGDRLVIEVENNGVGIQPKKKK-------------K 308
|
....*.
gi 1751489951 791 GSGVGL 796
Cdd:COG3275 309 GSGIGL 314
|
|
| COG3804 |
COG3804 |
Uncharacterized conserved protein [Function unknown]; |
75-122 |
3.37e-03 |
|
Uncharacterized conserved protein [Function unknown];
Pssm-ID: 443017 [Multi-domain] Cd Length: 338 Bit Score: 40.55 E-value: 3.37e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1751489951 75 DVDAVLARRPAVALVdelahtnAPGSRNPKRWQDVAELLAAGIDVVST 122
Cdd:COG3804 60 DADAVLALDADVVVY-------ATDSRLEEAVDDLERLLEAGVNVVTT 100
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
727-806 |
3.93e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.04 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 727 LERAVANIVENAVKYSPGGvPVTVAASALGDRVELRVVDRGPGVPDEAKDgifEPFQRFGDAPRGSGvGLGLAVARGFAE 806
Cdd:pfam13581 36 VGEACTNAVEHAYREGPEG-PVEVRLTSDGGGLVVTVADSGPPFDPLTLP---PPDLEEPDEDRKEG-GRGLALIRGLMD 110
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
733-823 |
5.13e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 40.28 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751489951 733 NIVEN---AVKYSPGGvPVTVAASALGDRVELRVVDRGPGVPDEAKDGIFEPfqrfGDAPRGSGVGLGLAVARGFAEAMG 809
Cdd:PRK11086 440 NLIENaleAVGGEEGG-EISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDK----GYSTKGSNRGVGLYLVKQSVENLG 514
|
90
....*....|....
gi 1751489951 810 GTLGAEDTPGGGLT 823
Cdd:PRK11086 515 GSIAVESEPGVGTQ 528
|
|
| |
