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Conserved domains on  [gi|1751471379|gb|QEV16638|]
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MbtH family protein [Streptomyces alboniger]

Protein Classification

MbtH family protein( domain architecture ID 10007125)

MbtH family protein may be required for the synthesis of antibiotics, siderophores or glycopeptidolipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-65 2.99e-36

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442482  Cd Length: 71  Bit Score: 116.12  E-value: 2.99e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751471379  1 MTNPFEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEAVWTDLRPKAPQD 65
Cdd:COG3251    1 MSNPFDDDDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLRE 65
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-65 2.99e-36

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 116.12  E-value: 2.99e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751471379  1 MTNPFEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEAVWTDLRPKAPQD 65
Cdd:COG3251    1 MSNPFDDDDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLRE 65
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-53 4.96e-32

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 104.90  E-value: 4.96e-32
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1751471379  1 MTNPFEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEA 53
Cdd:pfam03621  1 MTNPFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 5-53 3.16e-25

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 87.62  E-value: 3.16e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1751471379   5 FEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEA 53
Cdd:smart00923  1 FDDEDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-65 2.99e-36

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 116.12  E-value: 2.99e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751471379  1 MTNPFEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEAVWTDLRPKAPQD 65
Cdd:COG3251    1 MSNPFDDDDGTFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLRE 65
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-53 4.96e-32

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 104.90  E-value: 4.96e-32
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1751471379  1 MTNPFEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEA 53
Cdd:pfam03621  1 MTNPFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
MbtH smart00923
MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of ...
 5-53 3.16e-25

MbtH-like protein; This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. Many of the members of this family are found in known antibiotic synthesis gene clusters.


Pssm-ID: 197991  Cd Length: 49  Bit Score: 87.62  E-value: 3.16e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1751471379   5 FEDADGTYLVLVNDLRQHSLWPALSAVPAGWSAVHGPASRQACLDHVEA 53
Cdd:smart00923  1 FDDEDGTFLVLVNDEGQYSLWPAFLPVPAGWRVVGGPGSRAACLDYIEE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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