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Conserved domains on  [gi|1750618319|gb|KAA8635172|]
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hypothetical protein SMACR_06341 [Sordaria macrospora]

Protein Classification

BRCT_BRC1_like_rpt5 and BRCT_BRC1_like_rpt6 domain-containing protein( domain architecture ID 12866356)

protein containing domains BRCT_BRC1_like_rpt2, BRCT_BRC1_like_rpt3, BRCT_BRC1_like_rpt5, and BRCT_BRC1_like_rpt6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_BRC1_like_rpt6 cd18439
sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...
 707-831 1.40e-39

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.


:

Pssm-ID: 349392  Cd Length: 116  Bit Score: 142.05  E-value: 1.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 707 EERFGVTLETAISRARANRSRLLWGVPIFCTAEIKNGMQSYQTIAEANGAIFKVFRGRGGSAikpttpeEDGGAPPEPVY 786
Cdd:cd18439     1 EKKYGCTLAESLARAKANKGKLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKL-------GDGIAEKGPVV 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1750618319 787 LLTSPSgpEKALWPKFEEMAKKGNMEPRIVVSDWLLDVAMKQELT 831
Cdd:cd18439    74 LISTTK--EKKLWPKFLKNAREGGKEPRVYSTDWLLDVVLRQELV 116
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 339-406 7.22e-36

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


:

Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 129.81  E-value: 7.22e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:cd18438     1 YKITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDSY 68
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
 608-701 2.10e-35

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


:

Pssm-ID: 465266  Cd Length: 91  Bit Score: 129.18  E-value: 2.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 608 RVSSGPVEMRICLTGYKRWVNdkiREEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTAC 687
Cdd:pfam16770   1 KKSLPPYDIRAVLTGCERWID---KEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDC 77

                          90
                  ....*....|....
gi 1750618319 688 IEANKVLPIKDYLL 701
Cdd:pfam16770  78 LKEGKLPDEEDYLL 91
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 109-182 7.21e-34

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


:

Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 124.26  E-value: 7.21e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 109 FSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALK-KNPKCKIVLPHWFDDCFR 182
Cdd:cd18436     1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKrPELNIKIVLPHWFDDCFK 75
BRCT_BRC1_like_rpt3 cd18437
third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 242-319 1.36e-30

third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the third repeat. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group; it contains a conserved Trp, but not the Cys/Ser residue.


:

Pssm-ID: 349390  Cd Length: 78  Bit Score: 115.04  E-value: 1.36e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 242 KKVMISQDLPINQRLRNILTTLIEQSDGEVVQDVDACDMYVCQYRDGDDYVQASQQGKDVGNLAWLYYLIVHNEWTRP 319
Cdd:cd18437     1 KRFYLSADLNLGARRRKTISALIKGGGGKIVDTLADADIFIGRYRDGDEYLAASRSNKIVGNLSWLYHVLATGEWSSP 78
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 14-86 1.21e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


:

Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 38.11  E-value: 1.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750618319  14 CFIYFVQsksLSASLISELSKAVQKHGAEVLEPTKDGkiplehATHIVANTIDFEQYHD-ALQYMIPVVNTNWI 86
Cdd:cd00027     1 LVICFSG---LDDEEREELKKLIEALGGKVSESLSSK------VTHLIAKSPSGEKYYLaALAWGIPIVSPEWL 65
 
Name Accession Description Interval E-value
BRCT_BRC1_like_rpt6 cd18439
sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...
 707-831 1.40e-39

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.


Pssm-ID: 349392  Cd Length: 116  Bit Score: 142.05  E-value: 1.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 707 EERFGVTLETAISRARANRSRLLWGVPIFCTAEIKNGMQSYQTIAEANGAIFKVFRGRGGSAikpttpeEDGGAPPEPVY 786
Cdd:cd18439     1 EKKYGCTLAESLARAKANKGKLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKL-------GDGIAEKGPVV 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1750618319 787 LLTSPSgpEKALWPKFEEMAKKGNMEPRIVVSDWLLDVAMKQELT 831
Cdd:cd18439    74 LISTTK--EKKLWPKFLKNAREGGKEPRVYSTDWLLDVVLRQELV 116
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 339-406 7.22e-36

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 129.81  E-value: 7.22e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:cd18438     1 YKITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDSY 68
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
 608-701 2.10e-35

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 129.18  E-value: 2.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 608 RVSSGPVEMRICLTGYKRWVNdkiREEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTAC 687
Cdd:pfam16770   1 KKSLPPYDIRAVLTGCERWID---KEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDC 77

                          90
                  ....*....|....
gi 1750618319 688 IEANKVLPIKDYLL 701
Cdd:pfam16770  78 LKEGKLPDEEDYLL 91
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 109-182 7.21e-34

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 124.26  E-value: 7.21e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 109 FSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALK-KNPKCKIVLPHWFDDCFR 182
Cdd:cd18436     1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKrPELNIKIVLPHWFDDCFK 75
BRCT_BRC1_like_rpt3 cd18437
third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 242-319 1.36e-30

third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the third repeat. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group; it contains a conserved Trp, but not the Cys/Ser residue.


Pssm-ID: 349390  Cd Length: 78  Bit Score: 115.04  E-value: 1.36e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 242 KKVMISQDLPINQRLRNILTTLIEQSDGEVVQDVDACDMYVCQYRDGDDYVQASQQGKDVGNLAWLYYLIVHNEWTRP 319
Cdd:cd18437     1 KRFYLSADLNLGARRRKTISALIKGGGGKIVDTLADADIFIGRYRDGDEYLAASRSNKIVGNLSWLYHVLATGEWSSP 78
BRCT_BRC1_like_rpt5 cd17743
fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 616-691 1.09e-25

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.


Pssm-ID: 349374  Cd Length: 70  Bit Score: 100.78  E-value: 1.09e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319 616 MRICLTGYKRWvndkirEEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTACIEAN 691
Cdd:cd17743     1 VRLLFTGYKLW------TEKEIKKLKKLGISIVEDPDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEACLKAG 70
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 339-401 1.90e-25

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 99.97  E-value: 1.90e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLW 401
Cdd:pfam12738   1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
336-406 2.94e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 51.61  E-value: 2.94e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319  336 FRDMKITLSNYGGDA-RVYLENLITAAGATYTKTM-KADNTHLITARMNGEKCE--AAKEWNIEIVNHLWIEDSY 406
Cdd:smart00292   4 FKGKTFYITGSFDKEeRDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWLLDCL 78
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 105-181 6.85e-05

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 41.90  E-value: 6.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750618319 105 PRMIFSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKcqeALKKNPKCKIVLPHWFDDCF 181
Cdd:pfam00533   2 KEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEARTKKY---LKAKELGIPIVTEEWLLDCI 75
BRCT smart00292
breast cancer carboxy-terminal domain;
108-181 4.77e-04

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 39.67  E-value: 4.77e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319  108 IFSN-VILTCADIPEFDKETIIGATMALGGMESKDLTR-QTTHICALSMDHEKCQEALKKNPKCKIVLPHWFDDCF 181
Cdd:smart00292   3 LFKGkTFYITGSFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLDCL 78
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 14-86 1.21e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 38.11  E-value: 1.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750618319  14 CFIYFVQsksLSASLISELSKAVQKHGAEVLEPTKDGkiplehATHIVANTIDFEQYHD-ALQYMIPVVNTNWI 86
Cdd:cd00027     1 LVICFSG---LDDEEREELKKLIEALGGKVSESLSSK------VTHLIAKSPSGEKYYLaALAWGIPIVSPEWL 65
 
Name Accession Description Interval E-value
BRCT_BRC1_like_rpt6 cd18439
sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...
 707-831 1.40e-39

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.


Pssm-ID: 349392  Cd Length: 116  Bit Score: 142.05  E-value: 1.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 707 EERFGVTLETAISRARANRSRLLWGVPIFCTAEIKNGMQSYQTIAEANGAIFKVFRGRGGSAikpttpeEDGGAPPEPVY 786
Cdd:cd18439     1 EKKYGCTLAESLARAKANKGKLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKL-------GDGIAEKGPVV 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1750618319 787 LLTSPSgpEKALWPKFEEMAKKGNMEPRIVVSDWLLDVAMKQELT 831
Cdd:cd18439    74 LISTTK--EKKLWPKFLKNAREGGKEPRVYSTDWLLDVVLRQELV 116
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 339-406 7.22e-36

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 129.81  E-value: 7.22e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:cd18438     1 YKITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDSY 68
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
 608-701 2.10e-35

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 129.18  E-value: 2.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 608 RVSSGPVEMRICLTGYKRWVNdkiREEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTAC 687
Cdd:pfam16770   1 KKSLPPYDIRAVLTGCERWID---KEDLDKKKLRLLGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDC 77

                          90
                  ....*....|....
gi 1750618319 688 IEANKVLPIKDYLL 701
Cdd:pfam16770  78 LKEGKLPDEEDYLL 91
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 109-182 7.21e-34

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 124.26  E-value: 7.21e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 109 FSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALK-KNPKCKIVLPHWFDDCFR 182
Cdd:cd18436     1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALKrPELNIKIVLPHWFDDCFK 75
BRCT_BRC1_like_rpt3 cd18437
third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 242-319 1.36e-30

third BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the third repeat. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group; it contains a conserved Trp, but not the Cys/Ser residue.


Pssm-ID: 349390  Cd Length: 78  Bit Score: 115.04  E-value: 1.36e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 242 KKVMISQDLPINQRLRNILTTLIEQSDGEVVQDVDACDMYVCQYRDGDDYVQASQQGKDVGNLAWLYYLIVHNEWTRP 319
Cdd:cd18437     1 KRFYLSADLNLGARRRKTISALIKGGGGKIVDTLADADIFIGRYRDGDEYLAASRSNKIVGNLSWLYHVLATGEWSSP 78
BRCT_BRC1_like_rpt5 cd17743
fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 616-691 1.09e-25

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.


Pssm-ID: 349374  Cd Length: 70  Bit Score: 100.78  E-value: 1.09e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319 616 MRICLTGYKRWvndkirEEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTACIEAN 691
Cdd:cd17743     1 VRLLFTGYKLW------TEKEIKKLKKLGISIVEDPDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEACLKAG 70
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 339-401 1.90e-25

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 99.97  E-value: 1.90e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLW 401
Cdd:pfam12738   1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 341-406 3.36e-20

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 85.37  E-value: 3.36e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319 341 ITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:cd17730     3 ISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDIL 68
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 334-408 2.75e-16

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 74.11  E-value: 2.75e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319 334 PGFRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWN-IEIVNHLWIEDSYAK 408
Cdd:cd17731     1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEA 76
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 339-405 7.41e-15

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 69.70  E-value: 7.41e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 339 MKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKC-EAAKEWNIEIVNHLWIEDS 405
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWLLDC 68
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
 637-694 1.57e-10

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 57.63  E-value: 1.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 637 RRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTACIEANKVL 694
Cdd:cd17744    15 EKIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 336-406 3.53e-10

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 56.92  E-value: 3.53e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1750618319 336 FRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNgEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:pfam00533   6 FSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEART-KKYLKAKELGIPIVTEEWLLDCI 75
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 336-405 1.68e-09

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 54.93  E-value: 1.68e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1750618319 336 FRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAA-KEWNIEIVNHLWIEDS 405
Cdd:cd17710     2 FSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTDC 72
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 108-184 2.00e-09

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 54.85  E-value: 2.00e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750618319 108 IFSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEAlKKNPKCKIVLPHWFDDCFRLG 184
Cdd:cd17731     2 PFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFA-RKWNSIHIVTPEWLYDSIEAG 77
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 338-408 2.05e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 54.57  E-value: 2.05e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 338 DMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLI--TARMNGEKCEAAKEWNIEIVNHLWIEDSYAK 408
Cdd:cd17723     1 GLSISLTGFSGVDLLHISKLIKLLGAKYHESLTKDRSLLIvnSTEKKSDKINFAKKWGIPVVSVEWLWDCLKE 73
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 348-412 4.29e-09

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 53.88  E-value: 4.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 348 GDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEdsyaKCEVQ 412
Cdd:cd17742    13 PESVDELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLR----ACEVE 73
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 333-405 1.36e-08

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 53.01  E-value: 1.36e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 333 IPGFRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDS 405
Cdd:cd17746     4 LPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQS 76
BRCT smart00292
breast cancer carboxy-terminal domain;
336-406 2.94e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 51.61  E-value: 2.94e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319  336 FRDMKITLSNYGGDA-RVYLENLITAAGATYTKTM-KADNTHLITARMNGEKCE--AAKEWNIEIVNHLWIEDSY 406
Cdd:smart00292   4 FKGKTFYITGSFDKEeRDELKELIEALGGKVTSSLsSKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWLLDCL 78
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 106-189 5.98e-08

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 50.99  E-value: 5.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 106 RMIFSNVILTCADiPEFDKETIIgaTMALGGMESKDLTRQTTHICALSMDHEKCQEAlKKNPKCKIVLPHWFDDCFRLGR 185
Cdd:cd17729    18 VIVFSGVIPTGID-PERSRLWKL--AESLGAKVVTDLSPRTTHLVAAKLGTEKVKQA-LKMPGIHVVHPDWLWACAERWE 93


                  ....
gi 1750618319 186 RISE 189
Cdd:cd17729    94 RVDE 97
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 112-180 1.26e-07

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 49.28  E-value: 1.26e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 112 VILTCADIPEFDKETIIGATMALGGMESKDLTRQTTH-ICALSMDHEKCQEALKKNpkCKIVLPHWFDDC 180
Cdd:cd00027     1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHlIAKSPSGEKYYLAALAWG--IPIVSPEWLLDC 68
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 108-189 3.89e-07

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 48.38  E-value: 3.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 108 IFSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALKkNPKCKIVLPHWFDDCFRLGRRI 187
Cdd:cd17710     1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNLDKKCTHLVTGKASGAKYECALK-HEGIKIVTPDWVTDCIKAKTLL 79


                  ..
gi 1750618319 188 SE 189
Cdd:cd17710    80 DE 81
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 336-405 2.28e-06

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 46.53  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 336 FRDMKITLSNYGGDARVYLENLITAAGAT----------YTKTMKAdNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDS 405
Cdd:cd18434     2 LNGCVISVSQFTGTERDCLTHLAELLGAKvqdyfvrkanPSKGLLA-STHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 146-194 2.38e-06

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 46.41  E-value: 2.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1750618319 146 TTHICALSMDHEKCQEaLKKNPKCKIVLPHWFDDCFRLGRRISEAPYTL 194
Cdd:cd17719    40 VTHIIATNLPGSKIKK-LKKARNYKVVRPEWIVDSIKAGRLLPEAPYLL 87
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 336-416 2.48e-06

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 46.20  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750618319 336 FRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKceAAKEWNIEIVNHLWIEDSYAKCEVQSFS 415
Cdd:pfam16589   5 FEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDK--LAENTKLGVVSPQWIFDCVKKGKLLPLE 82


                  .
gi 1750618319 416 N 416
Cdd:pfam16589  83 N 83
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 133-181 4.60e-05

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 41.99  E-value: 4.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1750618319 133 ALGGMESKDLTRQTTHICALSMDHEKCQEALKKNpkCKIVLPHWFDDCF 181
Cdd:cd18438    22 ALGATYTKNLKPDNTHLITASPEGEKYEAAKEWN--IPIVNHLWLYDSY 68
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 341-408 4.68e-05

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 42.26  E-value: 4.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 341 ITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSYAK 408
Cdd:cd17725     4 FVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKK 71
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 359-410 6.30e-05

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 42.52  E-value: 6.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 359 TAAGATYTKTMKADNTHLITARMNGEKCEAAKEW-NIEIVNHLWIEDSYAKCE 410
Cdd:cd17729    41 ESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMpGIHVVHPDWLWACAERWE 93
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 105-181 6.85e-05

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 41.90  E-value: 6.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750618319 105 PRMIFSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKcqeALKKNPKCKIVLPHWFDDCF 181
Cdd:pfam00533   2 KEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEARTKKY---LKAKELGIPIVTEEWLLDCI 75
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 616-687 1.67e-04

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 40.42  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 616 MRICLTGYkrwvNDKIREEAdRRKLRAMGIQIVQD-NVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTAC 687
Cdd:cd00027     1 LVICFSGL----DDEEREEL-KKLIEALGGKVSESlSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 132-192 1.69e-04

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 40.72  E-value: 1.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750618319 132 MALGGMESKDLTRQTTH-ICALSmDHEKCQEALKKnpKCKIVLPHWFDDCFRLGRRISEAPY 192
Cdd:cd17725    22 LEMGAKYRPDWTADCTHlICAFA-NTPKYKQVKGA--GGIIVSKEWILDCYKKKKRLPWKRY 80
BRCT_p53bp1_rpt1 cd17745
first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, ...
 656-692 3.44e-04

first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family also includes Schizosaccharomyces pombe Crb2, which is a checkpoint mediator required for the cellular response to DNA damage. This model corresponds to the first BRCT domain.


Pssm-ID: 349376 [Multi-domain]  Cd Length: 99  Bit Score: 40.37  E-value: 3.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1750618319 656 YLAAPRMVRTMKFLRCLARGPEVISSDFVTACIEANK 692
Cdd:cd17745    63 FLIADSPSRTPKYLQALALGIPCVSHKWILDCIEAGK 99
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 634-699 4.31e-04

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 39.66  E-value: 4.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1750618319 634 EADRRKLR----AMGIQIVQDNVPCD-YLAAPRMvrtMKFLRCLARGPEVISSDFVTACIEANKVLPIKDY 699
Cdd:pfam16589  17 SPSRSKLKrlieANGGTVVDNINPAVyIVIAPYN---KTDKLAENTKLGVVSPQWIFDCVKKGKLLPLENY 84
BRCT smart00292
breast cancer carboxy-terminal domain;
108-181 4.77e-04

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 39.67  E-value: 4.77e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1750618319  108 IFSN-VILTCADIPEFDKETIIGATMALGGMESKDLTR-QTTHICALSMDHEKCQEALKKNPKCKIVLPHWFDDCF 181
Cdd:smart00292   3 LFKGkTFYITGSFDKEERDELKELIEALGGKVTSSLSSkTTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLDCL 78
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 617-694 5.58e-04

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 39.14  E-value: 5.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1750618319 617 RICLTGYkrwvnDKIREEADRRKLRAMGIQIVQDNVPCDYLAAPRMVRTMKFLRCLARGPEVISSDFVTACIEANKVL 694
Cdd:cd17712     3 RVLFTGF-----DPVQVRKLTKKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_Bard1_rpt1 cd17734
first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...
 652-694 1.02e-03

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.


Pssm-ID: 349366  Cd Length: 80  Bit Score: 38.74  E-value: 1.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1750618319 652 VPCDylAAPRMVRTMKFLRCLARGPEVISSDFVTACIEANKVL 694
Cdd:cd17734    40 VPAD--ERGVCPRTMKYLMGILAGKWIVSFEWVEACLKAKKLV 80
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 14-86 1.21e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 38.11  E-value: 1.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750618319  14 CFIYFVQsksLSASLISELSKAVQKHGAEVLEPTKDGkiplehATHIVANTIDFEQYHD-ALQYMIPVVNTNWI 86
Cdd:cd00027     1 LVICFSG---LDDEEREELKKLIEALGGKVSESLSSK------VTHLIAKSPSGEKYYLaALAWGIPIVSPEWL 65
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 133-187 2.31e-03

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 37.56  E-value: 2.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 133 ALGGMESKDLTRQTTHICALSMDHEKCQEALKKNPKckIVLPHWFDDCFRLGRRI 187
Cdd:cd17716    26 ELGAKVVKRLTKTVTHVVFKDGSQSTLEKAKKRNVK--LVSPLWVEACKETGKRV 78
BRCT_PARP1 cd17747
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ...
 336-405 2.61e-03

BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.


Pssm-ID: 349378 [Multi-domain]  Cd Length: 76  Bit Score: 37.51  E-value: 2.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1750618319 336 FRDMKITLSNYGGDARVYLENLITAAGATYTKTMKADNTHLITARMNGE----KCEAAKEWNIEIVNHLWIEDS 405
Cdd:cd17747     1 LTGMKFALIGKLSKSKDELKKLIEKLGGKVASKVTKKVTLCISTKAEVEkmskKMKEAKEAGVPVVSEDFLEDC 74
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 358-405 2.75e-03

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 37.21  E-value: 2.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1750618319 358 ITAAGATYTKTMKADNTHLITARMNGEKCEAA---KEWNIEIVNHLWIEDS 405
Cdd:cd18436    23 VLALGGQYSDELTRDVTHLIALSPDGDKYKTAlkrPELNIKIVLPHWFDDC 73
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 107-181 3.80e-03

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 37.07  E-value: 3.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1750618319 107 MIFSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALKKNPKCKIVLPHWFDDCF 181
Cdd:cd17740     1 KPLSGIVLCCTSIPAEQRTEIATKASKMGAAYTADLTSDVTHLVAGQVNTTKYKFAARSRPDIKVMTVEWVEHLY 75
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 109-177 4.03e-03

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 37.22  E-value: 4.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1750618319 109 FSNVILTCADIPEFDKETIIGATMALGGMESKDLTRQTTHICALSMDHEKCQEALKKnpKCKIVLPHWF 177
Cdd:cd17746     7 LFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKW--KINVVCVEWL 73
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 354-406 4.50e-03

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 36.79  E-value: 4.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1750618319 354 LENLitaaGATYTKTMKADNTHLITARMNGEKCEAAKEWNIEIVNHLWIEDSY 406
Cdd:cd17716    24 LEEL----GAKVVKRLTKTVTHVVFKDGSQSTLEKAKKRNVKLVSPLWVEACK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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