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Conserved domains on  [gi|1750443415|gb|QES73513|]
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winged helix-turn-helix transcriptional regulator [Clostridium diolis]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 11467951)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
2-94 6.20e-31

Predicted transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 111.59  E-value: 6.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415   2 IHITNLKESLPLFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTNLTGKHGLQKICSL 81
Cdd:COG4189     1 MVVLDDEESLEVLKALASETRLRILRLLAE-EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYL 79

                          90
                  ....*....|...
gi 1750443415  82 HEDKFVIDIGKQD 94
Cdd:COG4189    80 RVDKILIVLPGLD 92
 
Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
2-94 6.20e-31

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 111.59  E-value: 6.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415   2 IHITNLKESLPLFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTNLTGKHGLQKICSL 81
Cdd:COG4189     1 MVVLDDEESLEVLKALASETRLRILRLLAE-EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYL 79

                          90
                  ....*....|...
gi 1750443415  82 HEDKFVIDIGKQD 94
Cdd:COG4189    80 RVDKILIVLPGLD 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-90 1.17e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.32  E-value: 1.17e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750443415  14 FKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHEDKFVIDI 90
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR----REGRRVYYSLTDAERLLAL 72
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-84 7.09e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.17  E-value: 7.09e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415  13 LFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHED 84
Cdd:NF033788    4 LFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR----REGRWVYYRLADE 70
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-66 5.78e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 51.39  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1750443415  14 FKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKT 66
Cdd:pfam12840   4 AEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEV 56
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-86 4.61e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.13  E-value: 4.61e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415   25 ILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHEDKF 86
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESR----REGKRVYYSLTDEKV 58
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 4-65 3.95e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 3.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415   4 ITNLKESLPLFKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:TIGR01884 127 ISFIDLDLVPLLAGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
 
Name Accession Description Interval E-value
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
2-94 6.20e-31

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 111.59  E-value: 6.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415   2 IHITNLKESLPLFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTNLTGKHGLQKICSL 81
Cdd:COG4189     1 MVVLDDEESLEVLKALASETRLRILRLLAE-EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPGKRGRQKICYL 79

                          90
                  ....*....|...
gi 1750443415  82 HEDKFVIDIGKQD 94
Cdd:COG4189    80 RVDKILIVLPGLD 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-90 1.17e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.32  E-value: 1.17e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1750443415  14 FKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHEDKFVIDI 90
Cdd:cd00090     1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR----REGRRVYYSLTDAERLLAL 72
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-86 1.75e-12

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 62.21  E-value: 1.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415   1 MIHITNLKESLPLFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICS 80
Cdd:COG0640     1 MSETKELEELAELFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR----REGRWVYYR 75


                  ....*.
gi 1750443415  81 LHEDKF 86
Cdd:COG0640    76 LADEAL 81
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 13-84 7.09e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 60.17  E-value: 7.09e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415  13 LFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHED 84
Cdd:NF033788    4 LFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR----REGRWVYYRLADE 70
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
9-96 5.39e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 53.11  E-value: 5.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415   9 ESLPLFKALSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTN-LTGKHGLQKICSLHEDKFV 87
Cdd:COG1777     6 DLDRLLDALGNPTRRRILALLSE-EPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYReGREDGRARKYYRLSAFRLE 84


                  ....*....
gi 1750443415  88 IDIGKQDVE 96
Cdd:COG1777    85 VTLTPDLFA 93
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-66 5.78e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 51.39  E-value: 5.78e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1750443415  14 FKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKT 66
Cdd:pfam12840   4 AEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEV 56
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-86 4.61e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.13  E-value: 4.61e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415   25 ILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHEDKF 86
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESR----REGKRVYYSLTDEKV 58
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
20-64 2.13e-07

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 46.66  E-value: 2.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1750443415  20 DVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
19-65 2.21e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.42  E-value: 2.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1750443415  19 SDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:COG1846    37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
25-64 3.23e-05

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.20  E-value: 3.23e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1750443415   25 ILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 20-65 4.98e-05

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 41.73  E-value: 4.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1750443415   20 DVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:smart00344   3 EIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
17-114 6.97e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 43.73  E-value: 6.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1750443415  17 LSSDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTN----LT--GKHGLQKICSLHEDKFVIDI 90
Cdd:COG4742    13 FLSEKRKNILLLLAE-GPKTRSELAESLDVSRSTILRQLKELEERGLIERDDgeyeLTtlGRLVVEEMEPLLDTLEVLEE 91

                          90       100       110
                  ....*....|....*....|....*....|
gi 1750443415  91 GKQDVENSY------HIDLNIGHYSNYDIT 114
Cdd:COG4742    92 NRDYWETHDlsaippELLLRIGELGDATVI 121
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 25-64 7.94e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 39.84  E-value: 7.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1750443415  25 ILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLI 47
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 19-64 8.98e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 39.35  E-value: 8.98e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1750443415  19 SDVRMNILEILSQyKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-64 3.92e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.25  E-value: 3.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1750443415  13 LFKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:COG3398    90 ILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV 141
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 25-67 4.08e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.95  E-value: 4.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1750443415  25 ILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTT 67
Cdd:pfam12802  10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
16-64 5.68e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.29  E-value: 5.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1750443415  16 ALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLI 64
Cdd:COG2345     9 ALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
HTH_34 pfam13601
Winged helix DNA-binding domain;
21-65 7.62e-04

Winged helix DNA-binding domain;


Pssm-ID: 463932 [Multi-domain]  Cd Length: 80  Bit Score: 37.62  E-value: 7.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1750443415  21 VRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:pfam13601   1 VRLAIMSYLASVDEADFVELKEALEATDGNLSVHLRKLEKAGYIE 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
15-73 1.13e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1750443415  15 KALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIKTTNLTGKH 73
Cdd:COG3398    16 NVLDNDTRRRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRT 74
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 4-65 3.95e-03

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 3.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415   4 ITNLKESLPLFKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:TIGR01884 127 ISFIDLDLVPLLAGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
25-65 4.23e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 36.68  E-value: 4.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1750443415  25 ILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:COG1522    10 ILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 10-84 4.51e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 35.66  E-value: 4.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1750443415  10 SLPLFKALSSDVRMnILEILSQ----YKQlnmNELSEKLDLTNGAVTMHIKKLEECGLIKTTnltgKHGLQKICSLHED 84
Cdd:COG2512     6 ALLLYPELLEDERR-VLELLREnggrMTQ---SEIVKETGWSKSKVSRLLSRLEERGLIEKE----RVGRENVVELPED 76
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 4-65 4.68e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 37.36  E-value: 4.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1750443415   4 ITNLKESLPLFKALSSDVRMNILEILSQYKQLNMNELSEKLDLTNGAVTMHIKKLEECGLIK 65
Cdd:cd09655   123 IDFIELDLVPLLAGLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVE 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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