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Conserved domains on  [gi|1743189414|ref|XP_003258628|]
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toll-like receptor 1 [Nomascus leucogenys]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 3.40e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 3.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1743189414  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 3.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLETLQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1743189414 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1743189414 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 2.50e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.50e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1743189414  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFCMPELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 3.40e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 3.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1743189414  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-782 6.43e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 101.67  E-value: 6.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....*
gi 1743189414 778 IKLTG 782
Cdd:pfam01582 160 NKLNG 164
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 3.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLETLQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1743189414 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1743189414 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 1.63e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 432 SNVLTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLETLQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743189414 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIDQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-124 5.96e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743189414  69 SKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFN 124
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGN 59
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 2.50e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.50e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1743189414  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFCMPELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 2.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1743189414 423 KSLLSLNMSSNVLTDTIFRCLP------PRIKVLDLHSNKIKSIPKQVVKLETLQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLAevlaekESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.25e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  33 KNGLIYVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDMSVfkfNQELEYLDLSHNKLAKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1743189414 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 8.81e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 8.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD---MSVFKFNQeLEYLDLSHNKLAKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
445-500 3.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 445 PRIKVLDLHSNKIKSIPKQV-VKLETLQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 3.40e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 3.40e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1743189414  714 AHHNLFHEGSNNLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKHglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-782 6.43e-25

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 101.67  E-value: 6.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 716 HNLFhEGSNNLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWPKE----------KSKH--GLFWANLRAAIN 777
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSdeSKFWKKIAYDIS 159


                  ....*
gi 1743189414 778 IKLTG 782
Cdd:pfam01582 160 NKLNG 164
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 1.65e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 640 FISYSGHDSFWVKnELLPNLEKEGMQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1743189414 720 HEGSNNLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
353-526 3.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 353 LDFSNNLLTDtVFENCGHLTELETLILQMNQLKELSkiaEMTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMS 431
Cdd:COG4886   118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDlPEELGNL---TNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 432 SNVLTD---TIFRClpPRIKVLDLHSNKIKSIPKQVVKLETLQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSad 508
Cdd:COG4886   191 NNQITDlpePLGNL--TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP-- 266

                         170
                  ....*....|....*...
gi 1743189414 509 FFQSCQKMRSIKAGNNPF 526
Cdd:COG4886   267 PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
235-541 3.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 235 NILAKLQTNPKLSSLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGRLDFRDFNYSGTSLKALSIHQVVSdVFNF 314
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN-LTEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 315 PQSDIYEIFSNMNIINFTVSGTRMVHMlcPSTVSPFLHL---DFSNNLLTDtVFENCGHLTELETLILQMNQLKELSKIA 391
Cdd:COG4886   102 DLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEEL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 392 EmttQMKSLQQLDISQNSVSydEKKGDCSWTKSLLSLNMSSNVLTD---TIFRClpPRIKVLDLHSNKIKSIPkQVVKLE 468
Cdd:COG4886   179 G---NLTNLKELDLSNNQIT--DLPEPLGNLTNLEELDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLT 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1743189414 469 TLQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGNNPFQCTCELREFVKNIDQ 541
Cdd:COG4886   251 NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  29 VDRSKNGLIYVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLA 106
Cdd:COG4886   118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1743189414 107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-272 5.13e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  32 SKNGLIYVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDMSVFKFNQeLEYLDLSHNKLAKIs 109
Cdd:COG4886   167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNIGKVLLVLGETYGEKEDPEGLQ 185
Cdd:COG4886   244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 186 DFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNECSYFLNILAKLQTNPKLSSLTLNNIETTWNSFIRIL 265
Cdd:COG4886   322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401


                  ....*..
gi 1743189414 266 QLVWHTT 272
Cdd:COG4886   402 LLTLALL 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 1.63e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113  240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 432 SNVLTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLETLQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113  317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743189414 507 ADFFQSCQKMRSIKAGNNPFqcTCEL-REFVK----NIDQVSSEVVEGWPDSYKCDYPE 560
Cdd:PLN00113  397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR_8 pfam13855
Leucine rich repeat;
69-124 5.96e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1743189414  69 SKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKLAKIS---CHPTVNLKHLDLSFN 124
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGN 59
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 2.50e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 2.50e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1743189414  524 NPFQCTCELREFVKNIDQvssEVVEGWPDSYKCDYPESYRGtLLKDFCMPELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 2.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116   170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1743189414 423 KSLLSLNMSSNVLTDTIFRCLP------PRIKVLDLHSNKIKSIPKQVVKLETLQELN 474
Cdd:cd00116   250 ISLLTLSLSCNDITDDGAKDLAevlaekESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
316-484 4.59e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 316 QSDIYEIFSNMNIInftvsgTRMVHMLcPSTVSpflHLDFSNNLLTdtvfENCGHL-TELETLILQMNQLKELSKiaemt 394
Cdd:PRK15370  219 QGNIKTLYANSNQL------TSIPATL-PDTIQ---EMELSINRIT----ELPERLpSALQSLDLFHNKISCLPE----- 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 395 TQMKSLQQLDISQNSVSYDEKKgdcsWTKSLLSLNMSSNVLT----------------DTIFRCLP----PRIKVLDLHS 454
Cdd:PRK15370  280 NLPEELRYLSVYDNSIRTLPAH----LPSGITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSK 355

                         170       180       190
                  ....*....|....*....|....*....|
gi 1743189414 455 NKIKSIPKQVVKleTLQELNVAFNSLTDLP 484
Cdd:PRK15370  356 NQITVLPETLPP--TITTLDVSRNALTNLP 383
LRR_8 pfam13855
Leucine rich repeat;
48-105 8.50e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.50e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1743189414  48 TILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDMSVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 7.20e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414   2 TGIFPFAIIFMLILQIRIQLSEESEFLVDRSKNGLIYVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRI 81
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1743189414  82 qyldmsvFKFNQELEYLDLSHNKLAKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886   109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-526 1.11e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 351 LHLdFSNNLltdTVFENCGHLTELETLILQMNQLKELskiaEMTTQMKSLQQLDISQNSVSYDEKKGDCSwtkSLLSLNM 430
Cdd:cd21340    29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKI----ENLENLVNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 431 SSNvltdtifrCLPPRIKVL-DLHSnkIKSIpkqvvkLETLQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPS--A 507
Cdd:cd21340    98 ENQ--------RLPPGEKLTfDPRS--LAAL------SNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelL 161

                         170
                  ....*....|....*....
gi 1743189414 508 DFFQSCQKMRSIKAGNNPF 526
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.25e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  33 KNGLIYVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDMSVfkfNQELEYLDLSHNKLAKISCHP 112
Cdd:PRK15370  229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                          90
                  ....*....|....*...
gi 1743189414 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370  303 PSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 273-435 4.99e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 273 VWYFSISNVKLQGRLDFRDFNYsgTSLKALSIhqVVSDVF-NFPQSdiyeiFSNMNIINFTVSGTRMVHMLcPS---TVS 348
Cdd:PLN00113  430 VYFLDISNNNLQGRINSRKWDM--PSLQMLSL--ARNKFFgGLPDS-----FGSKRLENLDLSRNQFSGAV-PRklgSLS 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 349 PFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSYDEKKgDCSWTKSLLSL 428
Cdd:PLN00113  500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSGEIPK-NLGNVESLVQV 576


                  ....*..
gi 1743189414 429 NMSSNVL 435
Cdd:PLN00113  577 NISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 8.81e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 8.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD---MSVFKFNQeLEYLDLSHNKLAKIS 109
Cdd:cd21340   118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 2.47e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
445-500 3.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 445 PRIKVLDLHSNKIKSIPKQV-VKLETLQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 389-520 7.53e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414 389 KIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNVLTDTIFRCLPPRIKVLDLHSNKIK-SIPKQVVKL 467
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSF 163

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1743189414 468 ETLQELNVAFNSLT-DLPG-CGSFSSLSVLIIDHNSVshpSADFFQSCQKMRSIK 520
Cdd:PLN00113  164 SSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQL---VGQIPRELGQMKSLK 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-147 9.29e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 9.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1743189414  48 TILNISQNYISELwtSDILSLSKLRILIISHNRIQ--------------YLD--------------MSVFKFNQELEYLD 99
Cdd:cd21340    49 THLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISvveglenltnleelHIEnqrlppgekltfdpRSLAALSNSLRVLN 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1743189414 100 LSHNKLAKISC-HPTVNLKHLDLSFNAFDAL-PICKEFGNMSQLKFLGLS 147
Cdd:cd21340   127 ISGNNIDSLEPlAPLRNLEQLDASNNQISDLeELLDLLSSWPSLRELDLT 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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