NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1734260945|gb|QEL50686|]
View 

replication initiator protein [Cotton leaf curl Gezira alphasatellite]

Protein Classification

replication-associated family protein( domain architecture ID 10261052)

replication-associated family protein similar to replication-associated protein and Para-Rep C1/7/9, both of which are ATP-dependent helicases

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Viral_Rep super family cl03577
Putative viral replication protein; This is a family of viral ORFs from various plant and ...
 9-94 1.16e-16

Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.


The actual alignment was detected with superfamily member pfam02407:

Pssm-ID: 280553  Cd Length: 82  Bit Score: 73.37  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945   9 WCFTIFFlsstAPDLVLFFENTAVSYACWQEEESpTTKRRHLQGYLQCKGNRTLAQVKSLFGElNPHLEKQRARKtDEAR 88
Cdd:pfam02407   4 WCFTLNN----PTEFLSLFSQDELKYFVYQDERG-TTGTKHLQGFVEFKNRTSLGQMKKKFPG-RAHLEIARGSQ-EEAR 76


                  ....*.
gi 1734260945  89 DYCMKE 94
Cdd:pfam02407  77 DYCMKE 82
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 182-276 3.24e-16

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


:

Pssm-ID: 459992  Cd Length: 102  Bit Score: 73.02  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945 182 WVYGPDGgEGKSTFARDLFR--------SGTWFYTRGgSADNVSYQYIGcLGNNIVFDIPRDKKDylqysLIEMFKDRLV 253
Cdd:pfam00910   2 WLYGPPG-CGKSTLAKYLARallkklglPKDSVYSRN-PDDDFWDGYTG-QPVVIIDDFGQNPDG-----PDEAELIRLV 73

                          90       100
                  ....*....|....*....|....*....
gi 1734260945 254 VSNKYEPLMAP------MISCIHVVVMSN 276
Cdd:pfam00910  74 SSTPYPPPMAAleekgtPFTSKFVIVTSN 102
 
Name Accession Description Interval E-value
Viral_Rep pfam02407
Putative viral replication protein; This is a family of viral ORFs from various plant and ...
 9-94 1.16e-16

Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.


Pssm-ID: 280553  Cd Length: 82  Bit Score: 73.37  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945   9 WCFTIFFlsstAPDLVLFFENTAVSYACWQEEESpTTKRRHLQGYLQCKGNRTLAQVKSLFGElNPHLEKQRARKtDEAR 88
Cdd:pfam02407   4 WCFTLNN----PTEFLSLFSQDELKYFVYQDERG-TTGTKHLQGFVEFKNRTSLGQMKKKFPG-RAHLEIARGSQ-EEAR 76


                  ....*.
gi 1734260945  89 DYCMKE 94
Cdd:pfam02407  77 DYCMKE 82
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 182-276 3.24e-16

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 73.02  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945 182 WVYGPDGgEGKSTFARDLFR--------SGTWFYTRGgSADNVSYQYIGcLGNNIVFDIPRDKKDylqysLIEMFKDRLV 253
Cdd:pfam00910   2 WLYGPPG-CGKSTLAKYLARallkklglPKDSVYSRN-PDDDFWDGYTG-QPVVIIDDFGQNPDG-----PDEAELIRLV 73

                          90       100
                  ....*....|....*....|....*....
gi 1734260945 254 VSNKYEPLMAP------MISCIHVVVMSN 276
Cdd:pfam00910  74 SSTPYPPPMAAleekgtPFTSKFVIVTSN 102
 
Name Accession Description Interval E-value
Viral_Rep pfam02407
Putative viral replication protein; This is a family of viral ORFs from various plant and ...
 9-94 1.16e-16

Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.


Pssm-ID: 280553  Cd Length: 82  Bit Score: 73.37  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945   9 WCFTIFFlsstAPDLVLFFENTAVSYACWQEEESpTTKRRHLQGYLQCKGNRTLAQVKSLFGElNPHLEKQRARKtDEAR 88
Cdd:pfam02407   4 WCFTLNN----PTEFLSLFSQDELKYFVYQDERG-TTGTKHLQGFVEFKNRTSLGQMKKKFPG-RAHLEIARGSQ-EEAR 76


                  ....*.
gi 1734260945  89 DYCMKE 94
Cdd:pfam02407  77 DYCMKE 82
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 182-276 3.24e-16

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 73.02  E-value: 3.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945 182 WVYGPDGgEGKSTFARDLFR--------SGTWFYTRGgSADNVSYQYIGcLGNNIVFDIPRDKKDylqysLIEMFKDRLV 253
Cdd:pfam00910   2 WLYGPPG-CGKSTLAKYLARallkklglPKDSVYSRN-PDDDFWDGYTG-QPVVIIDDFGQNPDG-----PDEAELIRLV 73

                          90       100
                  ....*....|....*....|....*....
gi 1734260945 254 VSNKYEPLMAP------MISCIHVVVMSN 276
Cdd:pfam00910  74 SSTPYPPPMAAleekgtPFTSKFVIVTSN 102
DUF5906 pfam19263
Family of unknown function (DUF5906); This is a family of proteins of unknown function found ...
 183-287 7.24e-03

Family of unknown function (DUF5906); This is a family of proteins of unknown function found in viruses. This family is a P-loop member whose proteins are thought to be SF3 helicases, which are involved in replication initiation.


Pssm-ID: 466016 [Multi-domain]  Cd Length: 114  Bit Score: 35.81  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734260945 183 VYGPDGGEGKSTFARDLFRS--GTWFYTRGGSADNVSYQY----IGCLgNNIVFDIPRDKKDylQYSLIEMFK----DRL 252
Cdd:pfam19263   1 LIGILQGTGKSTLLEFILGKllGPSNVTALSDLLKLLGRFnsalQGKL-LIIIDEIGMASGE--WHKANGRLKslitEPI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1734260945 253 VVSNKYEPLMaPMISCIHVVVMSNFLPDMEKISSD 287
Cdd:pfam19263  78 SIERKGKDPY-EVKNYARFIFTSNHNWPLPAEDDD 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH