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Conserved domains on  [gi|1732261857]
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Chain A, Clathrin heavy chain 1

Protein Classification

clathrin heavy chain( domain architecture ID 10476644)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 6.20e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 6.20e-11
                          10        20
                  ....*....|....*....|....
gi 1732261857 331 EENIIPYITNVLQNPDLALRMAVR 354
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.47e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 6.64e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.64e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1732261857 256 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 8.24e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 8.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1732261857  19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.10e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.48e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.08  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732261857 148 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 6.20e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 6.20e-11
                          10        20
                  ....*....|....*....|....
gi 1732261857 331 EENIIPYITNVLQNPDLALRMAVR 354
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.47e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 6.64e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.64e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1732261857 256 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 8.24e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 8.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1732261857  19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.10e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.48e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.08  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732261857 148 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 6.20e-11

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 56.30  E-value: 6.20e-11
                          10        20
                  ....*....|....*....|....
gi 1732261857 331 EENIIPYITNVLQNPDLALRMAVR 354
Cdd:pfam09268   1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 5.47e-07

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 45.48  E-value: 5.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 198 AASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVG 234
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 6.64e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.71  E-value: 6.64e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1732261857 256 AQNDFPVAMQISEKHDVVFLITKYGYIHLYDLE 288
Cdd:pfam01394   5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 8.24e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 39.32  E-value: 8.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1732261857  19 GINPANIGFSTLTMESDKFICIREKVGeQAQVVIIDMN 56
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 3.10e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.78  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1732261857 296 NRISGETIFVTAPHEATAGIIGVN--RKGQVLSVCVE 330
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.48e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 35.08  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732261857 148 LAGCQIINYRTDAKQKWLLLTGISaqqNRVVGAMQLYSVD 187
Cdd:pfam01394   1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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