|
Name |
Accession |
Description |
Interval |
E-value |
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
1-512 |
1.48e-132 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 395.33 E-value: 1.48e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIA--------ADAVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYL- 71
Cdd:COG1384 9 KAWPFEEAdkllkrleKKGKEPVVFETGYGPSGLPHIGTFGEVARTTMVRRALRELGIPTRLICFSDDMDGLRKVPDNVp 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 72 DQEKFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKE 150
Cdd:COG1384 89 NQEMLEKYLGKPLTRIPDPfGCHES-FGEHFNARLRAFLDSFGFEYEFISATELYKSGRFDEALLRALENYDKIREILLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 151 VSKADRPSNWYSFQVICENCGKIATTVTTDYNGS--EVFYTCKpdatdyvkGCGHSGWVSPFNGNGKLPWKVEWVAKWDV 228
Cdd:COG1384 168 YLGEERRATYSPFLPICPKCGRVLQTPVIEVDAEagTVTYRCE--------GCGHEGETPVTGGNGKLQWKVDWAMRWAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 229 LGVTIEMAGKDHSQkgGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRt 307
Cdd:COG1384 240 LGVDFEPFGKDHAA--GSVDSGSKIAREVLGGEPPEGFVYELFLDeNGEKISKSKGNGLTVEEWLEYAEPESLRYFMFR- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 308 QPRTVINFAPnyETTTRLFRDYDTLINKY---SKSPELTEELMPLFYAQLGDEVKTF-QPFDFSTLISLLQVprLNIQD- 382
Cdd:COG1384 317 KPKKAKDLDF--DVIPKLVDEYDRFERKYfgeEDQEEEERLANRVYHIHVGNPPKEMpLPVPYRFLLNLAQV--ANAEDk 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 383 ----EVVQRSPQPLNEYDQQIINQRIAAAQLWLQDYADEEEKlvlYLEQVPDKANDFNAEQVAYLQKLMENLQNIPNWEA 458
Cdd:COG1384 393 evlwGFLRRYAPDATPETHPRLDERVERARRWARDFVPPTKK---FRLPEELPDVELDDKERAALEDLAERLEALEDWDA 469
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1731525170 459 EELQTIIFSTTKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISRL 512
Cdd:COG1384 470 EEIQNEVYEVGKEHGFELRDWFKALYEVLLGQEQGPRLGSFLALLGKEFVIALI 523
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
1-512 |
2.70e-122 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 368.37 E-value: 2.70e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAADAV------GYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYL-DQ 73
Cdd:PRK00750 5 KHWADEEAEKIIkrlgkkPPVVVETGIGPSGLPHIGNFREVARTDMVRRALRDLGIKTRLIFFSDDMDGLRKVPDNVpNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 74 EKFSPYLGFPLCNVPSPGDNASDYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSK 153
Cdd:PRK00750 85 EMLEEYLGKPLTEIPDPFGCHESYAEHFNAPLREFLDRFGIEYEFISATECYKSGRYDEAILTALENRDEIMEILLPYLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 154 ADRPSNWYSFQVICENCGKIATTVTTDYNG--SEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGV 231
Cdd:PRK00750 165 EERQATYSPFLPICPKCGKVLTTPVISYDAeaGTVTYDCE---------CGHEGEVPVTGGHGKLQWKVDWPMRWAALGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 232 TIEMAGKDHSQkgGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLR-FLMLRTQP 309
Cdd:PRK00750 236 DFEPFGKDHAS--ASYDTSKKIAREILGGEPPEPFVYELFLDkKGEKISKSKGNVITIEDWLEYAPPESLRlFMFARPKP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 310 RTVINFAPnyetTTRLFRDYDTLINKY---SKSPELTEELMPLFYAQLGDEVktfqPFDFSTLISLLQVPRLNIQD---E 383
Cdd:PRK00750 314 AKRLDFDV----IPKLVDEYDRFERKYfgqEEKKEEEELANPVYHIHNGNPL----PVPFRLLLNLAQIANAEDKEvlwG 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 384 VVQRSPQPLNEYDQQIINQRIAAAQLWLQDYADEEEKLvlyleQVPDKandfnaEQVAYLQKLMENLQNIP-NWEAEELQ 462
Cdd:PRK00750 386 FLKRYAPGATPETHPRLDRLVEYAINWYRDFVAPEKKY-----RAPTE------KERAALEDLDDALRELAdGADAEEIQ 454
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1731525170 463 TIIFST-TKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISRL 512
Cdd:PRK00750 455 NEIYEVaKKELGVNPRDWFKALYEVLLGQSQGPRLGSFIALLGIDFVIALI 505
|
|
| lysS_arch |
TIGR00467 |
lysyl-tRNA synthetase, archaeal and spirochete; This model represents the lysyl-tRNA ... |
1-511 |
3.53e-110 |
|
lysyl-tRNA synthetase, archaeal and spirochete; This model represents the lysyl-tRNA synthetases that are class I amino-acyl tRNA synthetases. It includes archaeal and spirochete examples of the enzyme. All other known examples are class IIc amino-acyl tRNA synthetases and seem to form a separate orthologous set. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273094 [Multi-domain] Cd Length: 515 Bit Score: 337.65 E-value: 3.53e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAADAVGYQ-----VVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLDQEk 75
Cdd:TIGR00467 1 MHWADVIAEKLKKEKpknlyTVASGITPSGHIHIGNFREVITADAIARALRDSGSEARFIYIADNYDPLRKVYPFLPEE- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 76 FSPYLGFPLCNVPSPGDNASDYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSKAD 155
Cdd:TIGR00467 80 LETYLGMPLTRIPDPEGCKTSYAEHFLIPFLESLPVLGINPEFIRASKQYTSGLYASQIKIALDHRKEISEILNEYRTSK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 156 RPSNWYSFQVICENCGKIATTVTTDYNGSEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGVTIEM 235
Cdd:TIGR00467 160 LEENWYPISVFCENCGRDTTTVNNYDNEYSIEYSCE---------CGNQESVDIYTGAIKLPWRVDWPARWKIEKVTFEP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 236 AGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFI--LVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRTVI 313
Cdd:TIGR00467 231 AGKDHAAAGGSYDTGVNIAKEIFQYSPPVTVQYEWIslKGKGGKMSSSKGDVISVKDVLEVYTPEITRFLFARTKPEFHI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 314 NFAPNyetTTRLFRDYDTLINKYSKSPELTEELMPLFY------AQLGDEVKTFQ-PFDFSTLIS-LLQVPRLNIQDEVV 385
Cdd:TIGR00467 311 SFDLD---VIKLYEDYDKFERFYYGVKDKDEEKKRAFKriyelsQPMPSERIPYQvPFRHLSVISqIFENNDIEKILEIL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 386 QRSPQPLNEYDQQIINQRIAAAQLWLQDYAdeEEKLVLYLEQVPDKANDFNAEQVAYLQKLMENLQNipNWE-AEELQTI 464
Cdd:TIGR00467 388 KRVQYTVDDQKDKLINKRLNCARNWIRKYA--PEDFKFSLRSKFDNMEILEENSKKAINELAEFLKK--NFEvATEIHNL 463
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1731525170 465 IFSTTKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISR 511
Cdd:TIGR00467 464 IYKISKENGIEPALAFQAIYKILLGKEYGPKLGGFIKILGIDRVEKR 510
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
1-350 |
6.91e-99 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 303.03 E-value: 6.91e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAA-------DAVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLD- 72
Cdd:pfam01921 1 KHWPDKEAEkllkerkKRGGEYLVASGISPSGLPHIGNFREVLRTDAVRRALRKRGFEVRLIAFSDDMDGLRKVPDNVPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 73 QEKFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEV 151
Cdd:pfam01921 81 SEMLEKYLGKPLTRIPDPfGCHES-YAEHFNAPFREFLDRFGIEYEFISATELYKSGLYDEAIKIALENRDEIMEILNPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 152 SKADRPSNWYSFQVICENCGKIATTVTTDYN-GSEVFYTCKpdatdyvkGCGHSGWVSPFNGNGKLPWKVEWVAKWDVLG 230
Cdd:pfam01921 160 RGEERQETYSPYLPICPKCGRVLTTPVVEYDeGGTIRYRCD--------ECGHEGEVDIRGGNGKLQWKVDWAMRWAALG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 231 VTIEMAGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQP 309
Cdd:pfam01921 232 VDFEPFGKDHAAPGGSYDTSSRIADEIFGGEPPEGFPYELILLkGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTKP 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1731525170 310 RTVINFAPnyETTTRLFRDYDTLINKY-SKSPELTEELMPLF 350
Cdd:pfam01921 312 KKAKDLDF--DVIPRLVDEYDRLERIYfAKQEEEKELLNRVY 351
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
1-336 |
3.53e-97 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 298.47 E-value: 3.53e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAAD------AVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLDQE 74
Cdd:cd00674 1 MHWADVIAEKiieerkGKEKYVVASGISPSGHIHIGNFREVITADLVARALRDLGFEVRLIYSWDDYDRLRKVPPNVPES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 75 kFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSK 153
Cdd:cd00674 81 -YEQYIGMPLSSVPDPfGCCES-YAEHFERPFEESLEKLGIEVEFISQSQMYKSGLYDENILIALEKRDEIMAILNEYRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 154 ADRPSNWYSFQVICENCGKIATTVTT-DYNGSEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGVT 232
Cdd:cd00674 159 RELQETWYPFMPYCEKCGKDTTTVEAyDAKAGTVTYKCE---------CGHEETVDIRTGRGKLTWRVDWPMRWAILGVD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 233 IEMAGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRT 311
Cdd:cd00674 230 FEPFGKDHASAGGSYDTGKEIAREIFGGEPPVPVMYEFIGLkGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPE 309
|
330 340
....*....|....*....|....*.
gi 1731525170 312 V-INFAPNYettTRLFRDYDTLINKY 336
Cdd:cd00674 310 KhIGFDLDI---LRLYDEYDRLERKY 332
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
1-512 |
1.48e-132 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 395.33 E-value: 1.48e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIA--------ADAVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYL- 71
Cdd:COG1384 9 KAWPFEEAdkllkrleKKGKEPVVFETGYGPSGLPHIGTFGEVARTTMVRRALRELGIPTRLICFSDDMDGLRKVPDNVp 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 72 DQEKFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKE 150
Cdd:COG1384 89 NQEMLEKYLGKPLTRIPDPfGCHES-FGEHFNARLRAFLDSFGFEYEFISATELYKSGRFDEALLRALENYDKIREILLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 151 VSKADRPSNWYSFQVICENCGKIATTVTTDYNGS--EVFYTCKpdatdyvkGCGHSGWVSPFNGNGKLPWKVEWVAKWDV 228
Cdd:COG1384 168 YLGEERRATYSPFLPICPKCGRVLQTPVIEVDAEagTVTYRCE--------GCGHEGETPVTGGNGKLQWKVDWAMRWAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 229 LGVTIEMAGKDHSQkgGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRt 307
Cdd:COG1384 240 LGVDFEPFGKDHAA--GSVDSGSKIAREVLGGEPPEGFVYELFLDeNGEKISKSKGNGLTVEEWLEYAEPESLRYFMFR- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 308 QPRTVINFAPnyETTTRLFRDYDTLINKY---SKSPELTEELMPLFYAQLGDEVKTF-QPFDFSTLISLLQVprLNIQD- 382
Cdd:COG1384 317 KPKKAKDLDF--DVIPKLVDEYDRFERKYfgeEDQEEEERLANRVYHIHVGNPPKEMpLPVPYRFLLNLAQV--ANAEDk 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 383 ----EVVQRSPQPLNEYDQQIINQRIAAAQLWLQDYADEEEKlvlYLEQVPDKANDFNAEQVAYLQKLMENLQNIPNWEA 458
Cdd:COG1384 393 evlwGFLRRYAPDATPETHPRLDERVERARRWARDFVPPTKK---FRLPEELPDVELDDKERAALEDLAERLEALEDWDA 469
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1731525170 459 EELQTIIFSTTKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISRL 512
Cdd:COG1384 470 EEIQNEVYEVGKEHGFELRDWFKALYEVLLGQEQGPRLGSFLALLGKEFVIALI 523
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
1-512 |
2.70e-122 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 368.37 E-value: 2.70e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAADAV------GYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYL-DQ 73
Cdd:PRK00750 5 KHWADEEAEKIIkrlgkkPPVVVETGIGPSGLPHIGNFREVARTDMVRRALRDLGIKTRLIFFSDDMDGLRKVPDNVpNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 74 EKFSPYLGFPLCNVPSPGDNASDYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSK 153
Cdd:PRK00750 85 EMLEEYLGKPLTEIPDPFGCHESYAEHFNAPLREFLDRFGIEYEFISATECYKSGRYDEAILTALENRDEIMEILLPYLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 154 ADRPSNWYSFQVICENCGKIATTVTTDYNG--SEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGV 231
Cdd:PRK00750 165 EERQATYSPFLPICPKCGKVLTTPVISYDAeaGTVTYDCE---------CGHEGEVPVTGGHGKLQWKVDWPMRWAALGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 232 TIEMAGKDHSQkgGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLR-FLMLRTQP 309
Cdd:PRK00750 236 DFEPFGKDHAS--ASYDTSKKIAREILGGEPPEPFVYELFLDkKGEKISKSKGNVITIEDWLEYAPPESLRlFMFARPKP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 310 RTVINFAPnyetTTRLFRDYDTLINKY---SKSPELTEELMPLFYAQLGDEVktfqPFDFSTLISLLQVPRLNIQD---E 383
Cdd:PRK00750 314 AKRLDFDV----IPKLVDEYDRFERKYfgqEEKKEEEELANPVYHIHNGNPL----PVPFRLLLNLAQIANAEDKEvlwG 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 384 VVQRSPQPLNEYDQQIINQRIAAAQLWLQDYADEEEKLvlyleQVPDKandfnaEQVAYLQKLMENLQNIP-NWEAEELQ 462
Cdd:PRK00750 386 FLKRYAPGATPETHPRLDRLVEYAINWYRDFVAPEKKY-----RAPTE------KERAALEDLDDALRELAdGADAEEIQ 454
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1731525170 463 TIIFST-TKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISRL 512
Cdd:PRK00750 455 NEIYEVaKKELGVNPRDWFKALYEVLLGQSQGPRLGSFIALLGIDFVIALI 505
|
|
| lysS_arch |
TIGR00467 |
lysyl-tRNA synthetase, archaeal and spirochete; This model represents the lysyl-tRNA ... |
1-511 |
3.53e-110 |
|
lysyl-tRNA synthetase, archaeal and spirochete; This model represents the lysyl-tRNA synthetases that are class I amino-acyl tRNA synthetases. It includes archaeal and spirochete examples of the enzyme. All other known examples are class IIc amino-acyl tRNA synthetases and seem to form a separate orthologous set. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273094 [Multi-domain] Cd Length: 515 Bit Score: 337.65 E-value: 3.53e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAADAVGYQ-----VVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLDQEk 75
Cdd:TIGR00467 1 MHWADVIAEKLKKEKpknlyTVASGITPSGHIHIGNFREVITADAIARALRDSGSEARFIYIADNYDPLRKVYPFLPEE- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 76 FSPYLGFPLCNVPSPGDNASDYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSKAD 155
Cdd:TIGR00467 80 LETYLGMPLTRIPDPEGCKTSYAEHFLIPFLESLPVLGINPEFIRASKQYTSGLYASQIKIALDHRKEISEILNEYRTSK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 156 RPSNWYSFQVICENCGKIATTVTTDYNGSEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGVTIEM 235
Cdd:TIGR00467 160 LEENWYPISVFCENCGRDTTTVNNYDNEYSIEYSCE---------CGNQESVDIYTGAIKLPWRVDWPARWKIEKVTFEP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 236 AGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFI--LVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRTVI 313
Cdd:TIGR00467 231 AGKDHAAAGGSYDTGVNIAKEIFQYSPPVTVQYEWIslKGKGGKMSSSKGDVISVKDVLEVYTPEITRFLFARTKPEFHI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 314 NFAPNyetTTRLFRDYDTLINKYSKSPELTEELMPLFY------AQLGDEVKTFQ-PFDFSTLIS-LLQVPRLNIQDEVV 385
Cdd:TIGR00467 311 SFDLD---VIKLYEDYDKFERFYYGVKDKDEEKKRAFKriyelsQPMPSERIPYQvPFRHLSVISqIFENNDIEKILEIL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 386 QRSPQPLNEYDQQIINQRIAAAQLWLQDYAdeEEKLVLYLEQVPDKANDFNAEQVAYLQKLMENLQNipNWE-AEELQTI 464
Cdd:TIGR00467 388 KRVQYTVDDQKDKLINKRLNCARNWIRKYA--PEDFKFSLRSKFDNMEILEENSKKAINELAEFLKK--NFEvATEIHNL 463
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1731525170 465 IFSTTKELGIQQPIAFKALYLSFLNKERGPKAGGLLSYLEKSFVISR 511
Cdd:TIGR00467 464 IYKISKENGIEPALAFQAIYKILLGKEYGPKLGGFIKILGIDRVEKR 510
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
1-350 |
6.91e-99 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 303.03 E-value: 6.91e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAA-------DAVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLD- 72
Cdd:pfam01921 1 KHWPDKEAEkllkerkKRGGEYLVASGISPSGLPHIGNFREVLRTDAVRRALRKRGFEVRLIAFSDDMDGLRKVPDNVPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 73 QEKFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEV 151
Cdd:pfam01921 81 SEMLEKYLGKPLTRIPDPfGCHES-YAEHFNAPFREFLDRFGIEYEFISATELYKSGLYDEAIKIALENRDEIMEILNPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 152 SKADRPSNWYSFQVICENCGKIATTVTTDYN-GSEVFYTCKpdatdyvkGCGHSGWVSPFNGNGKLPWKVEWVAKWDVLG 230
Cdd:pfam01921 160 RGEERQETYSPYLPICPKCGRVLTTPVVEYDeGGTIRYRCD--------ECGHEGEVDIRGGNGKLQWKVDWAMRWAALG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 231 VTIEMAGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQP 309
Cdd:pfam01921 232 VDFEPFGKDHAAPGGSYDTSSRIADEIFGGEPPEGFPYELILLkGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTKP 311
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1731525170 310 RTVINFAPnyETTTRLFRDYDTLINKY-SKSPELTEELMPLF 350
Cdd:pfam01921 312 KKAKDLDF--DVIPRLVDEYDRLERIYfAKQEEEKELLNRVY 351
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
1-336 |
3.53e-97 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 298.47 E-value: 3.53e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 1 MFWADKIAAD------AVGYQVVNDSKTPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPKYLDQE 74
Cdd:cd00674 1 MHWADVIAEKiieerkGKEKYVVASGISPSGHIHIGNFREVITADLVARALRDLGFEVRLIYSWDDYDRLRKVPPNVPES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 75 kFSPYLGFPLCNVPSP-GDNASdYAKYFIGEFFEVFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSK 153
Cdd:cd00674 81 -YEQYIGMPLSSVPDPfGCCES-YAEHFERPFEESLEKLGIEVEFISQSQMYKSGLYDENILIALEKRDEIMAILNEYRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 154 ADRPSNWYSFQVICENCGKIATTVTT-DYNGSEVFYTCKpdatdyvkgCGHSGWVSPFNGNGKLPWKVEWVAKWDVLGVT 232
Cdd:cd00674 159 RELQETWYPFMPYCEKCGKDTTTVEAyDAKAGTVTYKCE---------CGHEETVDIRTGRGKLTWRVDWPMRWAILGVD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 233 IEMAGKDHSQKGGSRDVANAISRKVLQKQPPFHSPYEFILV-NGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRT 311
Cdd:cd00674 230 FEPFGKDHASAGGSYDTGKEIAREIFGGEPPVPVMYEFIGLkGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPE 309
|
330 340
....*....|....*....|....*.
gi 1731525170 312 V-INFAPNYettTRLFRDYDTLINKY 336
Cdd:cd00674 310 KhIGFDLDI---LRLYDEYDRLERKY 332
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
28-362 |
4.00e-09 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 59.35 E-value: 4.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 28 HVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDalDTVpkyldqekfspylgfpLCNVPSPGDNASDYAKYFIGEFFE 107
Cdd:PRK14535 263 HLGHARVMVVFDMIARWLRECGYPLTYVRNITDID--DKI----------------IARAAENGETIGELTARFIQAMHE 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 108 VFEYLGIKPETYFLRDLYRSGKLNSYIDTFLKNAHLVREAYKEVSKADRPSNWYsfqvicencGKIATTVTTDYNGSEVF 187
Cdd:PRK14535 325 DADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYPAANGDVYYAVREFAAY---------GQLSGKSLDDLRAGERV 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 188 YT--CKPDATDYV----KGCGHSGWVSPFnGNGKLPWKVEWVA--------KWDV-------------------LGVTIE 234
Cdd:PRK14535 396 EVdgFKRDPLDFVlwkaAKAGEPAWESPW-GNGRPGWHIECSAmsenlfgdTFDIhgggadlqfphheneiaqsVGATGH 474
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 235 MAGKDHSQKGGSRDVANAISRKVlqkqppfHSpyEFILVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRTVIN 314
Cdd:PRK14535 475 TCGHHHAQTHHGQSIASHVKYWL-------HN--GFIRVDGEKMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLN 545
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1731525170 315 FAPNY--ETTTRLFRDYDTLINKYSKSPELTE---ELMPLFYAQLGDEVKTFQ 362
Cdd:PRK14535 546 YSDAHldDAKGALTRLYTTLKNTPAAEFMLSEnvnDYTRRFYAAMNDDFGTVE 598
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
269-368 |
5.84e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 52.03 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 269 EFILVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRTVINFAP--------NYETTTRLFRDYDTLINKYSKSP 340
Cdd:COG0215 257 GFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAHYRSPLDFSEealeeaekALERLYNALRRLEEALGAADSSA 336
|
90 100
....*....|....*....|....*...
gi 1731525170 341 ELTEELMPLFYAQLGDevktfqpfDFST 368
Cdd:COG0215 337 EEIEELREEFIAAMDD--------DFNT 356
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
269-311 |
8.17e-05 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 45.10 E-value: 8.17e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1731525170 269 EFILVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRT 311
Cdd:COG0143 319 GFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFG 361
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
22-112 |
1.13e-04 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 42.47 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1731525170 22 TPSGRVHVGSLRGVVIHDVIYRALKHAGKPVKFLYGVDDYDALDTVPkylDQEkfspylgfplcnvpsPGDNASDYAKYF 101
Cdd:cd00802 7 TPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDP---ANK---------------KGENAKAFVERW 68
|
90
....*....|.
gi 1731525170 102 IGEFFEVFEYL 112
Cdd:cd00802 69 IERIKEDVEYM 79
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
269-311 |
3.01e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 43.05 E-value: 3.01e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1731525170 269 EFILVNGTKMSSSKGVGSSAEEIAALLPPELLRFLMLRTQPRT 311
Cdd:pfam09334 316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPET 358
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
269-302 |
1.97e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 40.91 E-value: 1.97e-03
10 20 30
....*....|....*....|....*....|....
gi 1731525170 269 EFILVNGTKMSSSKGVGSSAEEIAALLPPELLRF 302
Cdd:PRK00133 321 GFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRY 354
|
|
| |
