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Conserved domains on  [gi|1730203857|gb|TYC87066|]
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bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase [Novosphingobium sp. BW1]

Protein Classification

bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase( domain architecture ID 10005279)

bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase catalyzes the ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CobU COG2087
Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme ...
 2-165 1.88e-86

Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme transport and metabolism]; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 441690  Cd Length: 172  Bit Score: 250.82  E-value: 1.88e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEADAVLVDC 81
Cdd:COG2087     4 LVLGGARSGKSRFAEKLAAASGKPVVYIATAQAFDEEMAERIARHRARRPAGWTTVEEPLDLAAALAALAPPGDVVLVDC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLML-----GDEDIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFV 156
Cdd:COG2087    84 LTLWLTNLLFaedawEEEDVEAEIDELLEALRALPGPVVLVSNEVGLGIVPENPLGRRFRDLLGRLNQRLAAAADEVYLV 163


                  ....*....
gi 1730203857 157 AAGLPLALK 165
Cdd:COG2087   164 VAGLPLKLK 172
 
Name Accession Description Interval E-value
CobU COG2087
Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme ...
 2-165 1.88e-86

Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme transport and metabolism]; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441690  Cd Length: 172  Bit Score: 250.82  E-value: 1.88e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEADAVLVDC 81
Cdd:COG2087     4 LVLGGARSGKSRFAEKLAAASGKPVVYIATAQAFDEEMAERIARHRARRPAGWTTVEEPLDLAAALAALAPPGDVVLVDC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLML-----GDEDIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFV 156
Cdd:COG2087    84 LTLWLTNLLFaedawEEEDVEAEIDELLEALRALPGPVVLVSNEVGLGIVPENPLGRRFRDLLGRLNQRLAAAADEVYLV 163


                  ....*....
gi 1730203857 157 AAGLPLALK 165
Cdd:COG2087   164 VAGLPLKLK 172
CobU pfam02283
Cobinamide kinase / cobinamide phosphate guanyltransferase; This family is composed of a group ...
 2-164 1.47e-80

Cobinamide kinase / cobinamide phosphate guanyltransferase; This family is composed of a group of bifunctional cobalamin biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape.


Pssm-ID: 426697  Cd Length: 167  Bit Score: 235.84  E-value: 1.47e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEaDAVLVDC 81
Cdd:pfam02283   2 LVTGGARSGKSRFAERLALASGGPVVYIATAQAFDEEMAERIARHRARRPAHWTTIEEPLDLAEALREAPGP-DVVLVDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLMLGDE----DIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFVA 157
Cdd:pfam02283  81 LTLWLTNLLLADDgeeeDIEAEVDELLAALKQLPAPVILVSNEVGMGIVPENALGRRFRDLLGRLNQRLAAAADEVYLVV 160


                  ....*..
gi 1730203857 158 AGLPLAL 164
Cdd:pfam02283 161 AGIPLKL 167
cobU PRK05800
adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated
 2-165 2.79e-77

adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated


Pssm-ID: 235612  Cd Length: 170  Bit Score: 227.75  E-value: 2.79e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEADAVLVDC 81
Cdd:PRK05800    5 LVTGGARSGKSRFAERLAAQSGLQVLYIATAQPFDDEMAARIAHHRQRRPAHWQTVEEPLDLAELLRADAAPGRCVLVDC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLM--LGDEDIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFVAAG 159
Cdd:PRK05800   85 LTTWVTNLLfeEGEEAIAAEIDALLAALQQLPAKIILVTNEVGMGIVPEYRLGRHFRDIAGRLNQQLAAAADEVYLVVAG 164


                  ....*.
gi 1730203857 160 LPLALK 165
Cdd:PRK05800  165 LPLKLK 170
CobU cd00544
Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU); CobU is a ...
 1-162 5.20e-74

Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU); CobU is a bacterial bifunctional cobalbumin biosynthesis enzyme which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity and is a key participant in the final stages of cobalamin biosynthesis where it is involved in nucleotide loop assembly. CobU is a homotrimer which functions both as a kinase and as a nucleotidyl transferase. It phosphorylates of adenosylcobinamide to form adenosylcobinamide phosphate (using a variety of nucleotides as the phosphate donor) and then adds GMP to adenosylcobinamide phosphate to form adenosylcobinamide-GDP, specifically using GTP.


Pssm-ID: 410861  Cd Length: 166  Bit Score: 219.33  E-value: 5.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   1 MLVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASqEADAVLVD 80
Cdd:cd00544     1 ILVTGGARSGKSRFAERLALQSGKDVVYVATAEAFDDEMAERIERHRKRRPAGWQTVEEPLDLAEALRALP-KGSVVLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  81 CLTLWLSNLMLGDEDIAGRSVQ-----LLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVF 155
Cdd:cd00544    80 CLTLWLTNLLFADDGWVEAAIEeeieaLLEALKACPATLIIVSNEVGWGIVPENPLGRRFRDLLGRLNQRLAAAADEVYL 159


                  ....*..
gi 1730203857 156 VAAGLPL 162
Cdd:cd00544   160 VVAGIPL 166
 
Name Accession Description Interval E-value
CobU COG2087
Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme ...
 2-165 1.88e-86

Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme transport and metabolism]; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441690  Cd Length: 172  Bit Score: 250.82  E-value: 1.88e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEADAVLVDC 81
Cdd:COG2087     4 LVLGGARSGKSRFAEKLAAASGKPVVYIATAQAFDEEMAERIARHRARRPAGWTTVEEPLDLAAALAALAPPGDVVLVDC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLML-----GDEDIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFV 156
Cdd:COG2087    84 LTLWLTNLLFaedawEEEDVEAEIDELLEALRALPGPVVLVSNEVGLGIVPENPLGRRFRDLLGRLNQRLAAAADEVYLV 163


                  ....*....
gi 1730203857 157 AAGLPLALK 165
Cdd:COG2087   164 VAGLPLKLK 172
CobU pfam02283
Cobinamide kinase / cobinamide phosphate guanyltransferase; This family is composed of a group ...
 2-164 1.47e-80

Cobinamide kinase / cobinamide phosphate guanyltransferase; This family is composed of a group of bifunctional cobalamin biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape.


Pssm-ID: 426697  Cd Length: 167  Bit Score: 235.84  E-value: 1.47e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEaDAVLVDC 81
Cdd:pfam02283   2 LVTGGARSGKSRFAERLALASGGPVVYIATAQAFDEEMAERIARHRARRPAHWTTIEEPLDLAEALREAPGP-DVVLVDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLMLGDE----DIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFVA 157
Cdd:pfam02283  81 LTLWLTNLLLADDgeeeDIEAEVDELLAALKQLPAPVILVSNEVGMGIVPENALGRRFRDLLGRLNQRLAAAADEVYLVV 160


                  ....*..
gi 1730203857 158 AGLPLAL 164
Cdd:pfam02283 161 AGIPLKL 167
cobU PRK05800
adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated
 2-165 2.79e-77

adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated


Pssm-ID: 235612  Cd Length: 170  Bit Score: 227.75  E-value: 2.79e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   2 LVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASQEADAVLVDC 81
Cdd:PRK05800    5 LVTGGARSGKSRFAERLAAQSGLQVLYIATAQPFDDEMAARIAHHRQRRPAHWQTVEEPLDLAELLRADAAPGRCVLVDC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  82 LTLWLSNLM--LGDEDIAGRSVQLLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVFVAAG 159
Cdd:PRK05800   85 LTTWVTNLLfeEGEEAIAAEIDALLAALQQLPAKIILVTNEVGMGIVPEYRLGRHFRDIAGRLNQQLAAAADEVYLVVAG 164


                  ....*.
gi 1730203857 160 LPLALK 165
Cdd:PRK05800  165 LPLKLK 170
CobU cd00544
Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU); CobU is a ...
 1-162 5.20e-74

Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU); CobU is a bacterial bifunctional cobalbumin biosynthesis enzyme which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity and is a key participant in the final stages of cobalamin biosynthesis where it is involved in nucleotide loop assembly. CobU is a homotrimer which functions both as a kinase and as a nucleotidyl transferase. It phosphorylates of adenosylcobinamide to form adenosylcobinamide phosphate (using a variety of nucleotides as the phosphate donor) and then adds GMP to adenosylcobinamide phosphate to form adenosylcobinamide-GDP, specifically using GTP.


Pssm-ID: 410861  Cd Length: 166  Bit Score: 219.33  E-value: 5.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857   1 MLVLGGARSGKSRYAQARIETVPGRLAFIATAHAFDAEMEERIARHQADRDARWTTYEAPLDLAGTLRRASqEADAVLVD 80
Cdd:cd00544     1 ILVTGGARSGKSRFAERLALQSGKDVVYVATAEAFDDEMAERIERHRKRRPAGWQTVEEPLDLAEALRALP-KGSVVLLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730203857  81 CLTLWLSNLMLGDEDIAGRSVQ-----LLDALTGCTVPVAFVANEVGMGIVPDNALSRRFRDEAGRLNQRLALEVNEVVF 155
Cdd:cd00544    80 CLTLWLTNLLFADDGWVEAAIEeeieaLLEALKACPATLIIVSNEVGWGIVPENPLGRRFRDLLGRLNQRLAAAADEVYL 159


                  ....*..
gi 1730203857 156 VAAGLPL 162
Cdd:cd00544   160 VVAGIPL 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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