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Conserved domains on  [gi|1724176693|ref|WP_146983534|]
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nucleotide exchange factor GrpE, partial [Lujinxingia vulgaris]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10001738)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

CATH:  3.90.20.20|2.30.22.10
Gene Ontology:  GO:0000774|GO:0051087|GO:0042803|GO:0006457
SCOP:  4003783|4002724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 20-160 1.64e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 158.39  E-value: 1.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  20 DALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALEsvpaeAIEQNEHLKSLVTGVE 99
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDEDVKSLLEGVE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693 100 MTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:COG0576    77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVL 137
 
Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 20-160 1.64e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 158.39  E-value: 1.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  20 DALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALEsvpaeAIEQNEHLKSLVTGVE 99
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDEDVKSLLEGVE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693 100 MTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:COG0576    77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVL 137
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 11-160 9.85e-50

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 158.68  E-value: 9.85e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAIEQNE- 89
Cdd:PRK14141   32 EDDPEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPAEARAAADa 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693  90 HLKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14141  112 GLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVL 182
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 27-160 6.04e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 154.20  E-value: 6.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  27 AQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEaieqnEHLKSLVTGVEMTEKSLL 106
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE-----EELKNLLEGVEMTLKQLL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1724176693 107 EAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:cd00446    76 KVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVL 129
GrpE pfam01025
GrpE;
13-160 1.01e-45

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 146.98  E-value: 1.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  13 ENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPaeaieQNEHLK 92
Cdd:pfam01025  14 ESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAP-----ENEDVK 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724176693  93 SLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVL 156
 
Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 20-160 1.64e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 158.39  E-value: 1.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  20 DALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALEsvpaeAIEQNEHLKSLVTGVE 99
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDEDVKSLLEGVE 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693 100 MTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:COG0576    77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVL 137
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 11-160 9.85e-50

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 158.68  E-value: 9.85e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAIEQNE- 89
Cdd:PRK14141   32 EDDPEPDPLEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALDAIPAEARAAADa 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693  90 HLKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14141  112 GLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTIGERVL 182
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 27-160 6.04e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 154.20  E-value: 6.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  27 AQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEaieqnEHLKSLVTGVEMTEKSLL 106
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKE-----EELKNLLEGVEMTLKQLL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1724176693 107 EAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:cd00446    76 KVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVL 129
GrpE pfam01025
GrpE;
13-160 1.01e-45

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 146.98  E-value: 1.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  13 ENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPaeaieQNEHLK 92
Cdd:pfam01025  14 ESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAP-----ENEDVK 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724176693  93 SLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVL 156
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 8-160 2.02e-43

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 142.80  E-value: 2.02e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693   8 VPFPGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAieQ 87
Cdd:PRK14155   11 GPFEADDAAQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASPKDS--A 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724176693  88 NEHLKSLVTGVEMTEKSLLEAFEKNHIKRIDP-VGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14155   89 DPAVKNFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLV 162
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 13-160 5.10e-34

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 118.18  E-value: 5.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  13 ENELDETDA----LRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPaeaieQN 88
Cdd:PRK14140   36 AELLDEEQAkiaeLEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEA-----DD 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724176693  89 EHLKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14140  111 EQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVI 182
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 13-160 9.63e-31

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 109.62  E-value: 9.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  13 ENELDETDAlraEVAQLKEQL-----------LRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVP 81
Cdd:PRK14150   33 EDELDEADA---RIAELEAQLaeaqaeerdsvLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVIDNLERALQAAD 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724176693  82 AEaieqNEHLKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14150  110 KE----NEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVMQKGYTLNGRLL 184
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 2-160 1.42e-30

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 108.71  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693   2 NEDVGEVPFPGENELD-ETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESV 80
Cdd:PRK14151   11 APEAAQAEAAAGDDLTaRVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGLELS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  81 PAEaieqNEHLKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14151   91 SAD----DEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYLLNGRLL 166
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 21-160 4.24e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 107.75  E-value: 4.24e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  21 ALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALesvpaeAIEqNEHLKSLVTGVEM 100
Cdd:PRK14139   43 EAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPVKDSLEAAL------ADE-SGDLEKLREGVEL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693 101 TEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEdPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14139  116 TLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVP-AEQEPNTVVAVLQKGYTIADRVL 174
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 3-160 8.37e-29

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 104.29  E-value: 8.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693   3 EDVGEVPFPGENEldETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPA 82
Cdd:PRK14161   14 NDIAEEIVETANP--EITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPA 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724176693  83 EAieqNEHLKSLVTGVEMTEKSLLEAFEKNHIKRIDP-VGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14161   92 NS---DVEVTNIIAGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLL 167
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 17-160 2.99e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 97.71  E-value: 2.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  17 DETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAieqnehlKSLVT 96
Cdd:PRK14147   25 AEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTAAGTEP-------SPLRD 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724176693  97 GVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14147   98 GLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLL 161
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 18-160 4.59e-25

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 94.91  E-value: 4.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  18 ETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVpaeaiEQNEHLKSLVTG 97
Cdd:PRK14153   41 ETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALESA-----RTAEDMNSIVEG 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724176693  98 VEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14153  116 IEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVCKPGYALNSKVI 178
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 11-160 2.28e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 85.66  E-value: 2.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALeSVPAEaieqNEH 90
Cdd:PRK14162   40 PVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERAL-AVKAD----DEA 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724176693  91 LKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAM--VEIEDPERaAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14162  115 AKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVqtVAAENDDQ-KDHVVQVLQKGYQYKDRTL 185
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 13-160 7.44e-21

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 84.42  E-value: 7.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  13 ENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRAL--ESVPAEAIEQNEh 90
Cdd:PRK14148   43 ERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALkhEVKLEEAIAMKE- 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  91 lkslvtGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14148  122 ------GIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNTIFDVFQKGYMLNGRIV 185
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 12-160 4.32e-19

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 79.53  E-value: 4.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  12 GENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAIEQnehl 91
Cdd:PRK14149   38 SEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALKSAAEVDKES---- 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1724176693  92 kSLVTGVEMTEKSLLEAFEKNHIKRIDPVGErLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14149  114 -ALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVL 180
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 21-160 1.30e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 78.43  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  21 ALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVpaeaieQNEHLKSLVTGVEM 100
Cdd:PRK14158   51 AKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALDHA------DEESMSAIIEGIRM 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693 101 TEKSLLEAFEKNHIKRID-PVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14158  125 TLSMLLSTLKKFGVTPVEaEKGTPFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLNERLL 185
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 11-160 1.70e-18

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 78.23  E-value: 1.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDALRAEVAQLK-EQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESvpaeAIEQNE 89
Cdd:PRK14144   45 PSYTALEEQLTLAEQKAHENwEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQALQL----ADKNSD 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1724176693  90 hlKSLVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14144  121 --PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVI 189
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 18-153 8.43e-17

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 74.00  E-value: 8.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  18 ETDALRAEVAQLKEQLLRAMADAENTRTRARKD----RDEAAKYAASGITKDLlsvaDNLRRaLESVPAeaieQNEHLKS 93
Cdd:PRK14146   62 ELDNAKKEIESLKDSWARERAEFQNFKRRSAQEfvsiRKEAVKSLVSGFLNPI----DNLER-VGATQN----QSEELKP 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  94 LVTGVEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGY 153
Cdd:PRK14146  133 FVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGY 192
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 30-158 1.85e-16

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 72.78  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  30 KEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESvpaeAIEQNEHLKSLVTGVEMTEKSLLEAF 109
Cdd:PRK10325   59 RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEV----ADKANPDMSAMVEGIELTLKSMLDVV 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1724176693 110 EKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDR 158
Cdd:PRK10325  135 RKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGR 183
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 17-160 2.31e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 72.87  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  17 DETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALesvpaeAIEQNehLKSLVT 96
Cdd:PRK14160   68 EENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAA------AVEGS--VEDLKK 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1724176693  97 GVEMTEKSLLEAFEKNHIKRIDPVGErLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14160  140 GIEMTVKQFKTSLEKLGVEEISTEGE-FDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVI 202
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 10-160 2.48e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 69.84  E-value: 2.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  10 FPGENELD-ETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEaieqN 88
Cdd:PRK14154   51 FPSREKLEgQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASE----D 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724176693  89 EHLKSLVTGVEMTEKSLLEAFEKNHIKRIDP-VGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14154  127 PQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVL 199
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 11-160 1.57e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 56.38  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDAlRAEvaQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALesvpaeaieQNEH 90
Cdd:PRK14156   31 PEKSELELANE-RAD--EFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERAL---------AVEG 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1724176693  91 LKSLV-TGVEMTEKSLLEAFEKNHIKRIdpVGERLNPHYHEAMVEIE-DPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14156   99 LTDDVkKGLEMVQESLIQALKEEGVEEV--AVDSFDHNLHMAVQTLPaDDEHPADSIAQVFQKGYKLHERLL 168
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 18-160 1.58e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 54.73  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  18 ETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVPAEAIEQNEHLKSLvTG 97
Cdd:PRK14143   75 ELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSY-QG 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724176693  98 VEmteKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14143  154 LY---KQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVL 213
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 18-160 1.57e-08

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 51.67  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  18 ETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRAlesvpaeaieqNEHlKSLVTG 97
Cdd:PRK14163   48 QLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRA-----------REH-GELVGG 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1724176693  98 VEMTEKSLLEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14163  116 FKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTI 178
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 3-160 4.09e-08

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 50.73  E-value: 4.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693   3 EDVGEVPFPGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRALESVpa 82
Cdd:PRK14157   70 EKTGEAQSDSDDTLTPLGQAKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDRIREHS-- 147

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1724176693  83 eaiEQNEHLKSLVTGVEmteksllEAFEKNHIKRIDPVGERLNPHYHEAMVEIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14157  148 ---EMDDSFKAVAAKID-------KAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVI 215
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 11-160 4.21e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 50.38  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1724176693  11 PGENELDETDALRAEVAQLKEQLLRAMADAENTRTRARKDRDEAAKYAASGITKDLLSVADNLRRA-----LESVPAEAI 85
Cdd:PRK14142   34 PGGTAAADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERArkhgdLESGPLKSV 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1724176693  86 EqnEHLKSLVTGVEMTekslleAFEKNhikridpvGERLNPHYHEAMV-EIEDPERAAGTVSQVFEPGYVLHDRLL 160
Cdd:PRK14142  114 A--DKLDSALTGLGLV------AFGAE--------GEDFDPVLHEAVQhEGDGGQGSKPVIGTVMRQGYQLGEQVL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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