tumor supressor p53, partial [Lagurus lagurus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| P53 super family | cl14608 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-66 | 9.87e-25 | ||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. The actual alignment was detected with superfamily member cd08367: Pssm-ID: 472693 Cd Length: 179 Bit Score: 90.02 E-value: 9.87e-25
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| Name | Accession | Description | Interval | E-value | ||
| P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-66 | 9.87e-25 | ||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 90.02 E-value: 9.87e-25
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| P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
1-66 | 1.27e-19 | ||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 76.94 E-value: 1.27e-19
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| Name | Accession | Description | Interval | E-value | ||
| P53 | cd08367 | P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ... |
1-66 | 9.87e-25 | ||
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes. Pssm-ID: 176262 Cd Length: 179 Bit Score: 90.02 E-value: 9.87e-25
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| P53 | pfam00870 | P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ... |
1-66 | 1.27e-19 | ||
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort. Pssm-ID: 459972 [Multi-domain] Cd Length: 191 Bit Score: 76.94 E-value: 1.27e-19
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